US5247941A - Multifunction collecting device for body fluids - Google Patents
Multifunction collecting device for body fluids Download PDFInfo
- Publication number
- US5247941A US5247941A US07/818,637 US81863792A US5247941A US 5247941 A US5247941 A US 5247941A US 81863792 A US81863792 A US 81863792A US 5247941 A US5247941 A US 5247941A
- Authority
- US
- United States
- Prior art keywords
- retaining
- blood
- additive
- compartments
- body fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000001124 body fluid Anatomy 0.000 title claims abstract description 25
- 239000010839 body fluid Substances 0.000 title claims abstract description 25
- 239000000654 additive Substances 0.000 claims abstract description 18
- 238000004458 analytical method Methods 0.000 claims abstract description 17
- 230000000996 additive effect Effects 0.000 claims abstract description 14
- 239000003755 preservative agent Substances 0.000 claims abstract description 6
- 230000002335 preservative effect Effects 0.000 claims abstract description 6
- 239000002250 absorbent Substances 0.000 claims abstract description 5
- 230000002745 absorbent Effects 0.000 claims abstract description 5
- 239000003242 anti bacterial agent Substances 0.000 claims abstract description 5
- 239000000834 fixative Substances 0.000 claims abstract description 5
- 235000015097 nutrients Nutrition 0.000 claims abstract description 5
- 101710186708 Agglutinin Proteins 0.000 claims abstract description 3
- 206010018910 Haemolysis Diseases 0.000 claims abstract description 3
- 101710146024 Horcolin Proteins 0.000 claims abstract description 3
- 101710189395 Lectin Proteins 0.000 claims abstract description 3
- 101710179758 Mannose-specific lectin Proteins 0.000 claims abstract description 3
- 101710150763 Mannose-specific lectin 1 Proteins 0.000 claims abstract description 3
- 101710150745 Mannose-specific lectin 2 Proteins 0.000 claims abstract description 3
- 239000000910 agglutinin Substances 0.000 claims abstract description 3
- 230000000844 anti-bacterial effect Effects 0.000 claims abstract description 3
- 230000003115 biocidal effect Effects 0.000 claims abstract description 3
- 239000003599 detergent Substances 0.000 claims abstract description 3
- 230000002070 germicidal effect Effects 0.000 claims abstract description 3
- 230000008588 hemolysis Effects 0.000 claims abstract description 3
- 239000003381 stabilizer Substances 0.000 claims abstract description 3
- 239000004094 surface-active agent Substances 0.000 claims abstract description 3
- 230000000717 retained effect Effects 0.000 claims description 5
- 239000008280 blood Substances 0.000 abstract description 55
- 210000004369 blood Anatomy 0.000 abstract description 55
- 238000000034 method Methods 0.000 abstract description 15
- 244000005700 microbiome Species 0.000 description 13
- 241000282414 Homo sapiens Species 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000012360 testing method Methods 0.000 description 7
- 210000001215 vagina Anatomy 0.000 description 7
- 230000000740 bleeding effect Effects 0.000 description 6
- 230000027758 ovulation cycle Effects 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 3
- 210000004914 menses Anatomy 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 229920003023 plastic Polymers 0.000 description 3
- 241000725303 Human immunodeficiency virus Species 0.000 description 2
- 208000027418 Wounds and injury Diseases 0.000 description 2
- 210000002255 anal canal Anatomy 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000030507 AIDS Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 208000019802 Sexually transmitted disease Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000000624 ear auricle Anatomy 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 208000002672 hepatitis B Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920000915 polyvinyl chloride Polymers 0.000 description 1
- 239000004800 polyvinyl chloride Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 206010046885 vaginal cancer Diseases 0.000 description 1
- 208000013139 vaginal neoplasm Diseases 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150015—Source of blood
- A61B5/150045—Source of blood for blood from vagina, placenta, colon or mouth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
- A61B5/150251—Collection chamber divided into at least two compartments, e.g. for division of samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
- A61F13/2002—Tampons, e.g. catamenial tampons; Accessories therefor characterised by the use
- A61F13/202—Catamenial tampons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S604/00—Surgery
- Y10S604/904—Tampons
Definitions
- the present invention relates to methods and devices for collecting body fluids such as blood so that the fluid can thereafter be subjected to two or more separate analyses.
- a device which is capable of receiving and holding blood is introduced into the interior of a cavity of a body of a living creature, this cavity being one in which blood is in any event present.
- the device is removed from the cavity after the device has remained therein for a period of time sufficient to receive and hold blood, which is thus removed with the device.
- the device is then separated into separate compartments such that the blood in each of these compartments can then be subjected to different analyses.
- the above device of the invention includes an outer holder which is formed with an entrance means through which blood can flow into the interior of the holder, and within the interior of the holder are two or more separate compartments capable of retaining and holding the blood. According to a particular feature of the invention, this device may be incorporated into a tampon inserted into the vagina during the menstrual cycle.
- each of the compartments may be impregnated with or contain a different substance for facilitating the later analysis of the blood contained therein.
- a fixative for example, a fixative, a preservative, nutrients, red cell stabilizers, an antibacterial, a germicide, an agglutinin (for clotting the red cells), a surfactant, a detergent, an additive to prevent hemolysis (such as dextran), an antibiotic (to kill certain microorganisms collected in a body fluid sample in which there is no particular interest), and monoclonal antibodies (e.g., to detect the HIV virus), etc.
- the term "microorganisms" for purposes of the present invention is deemed to include bacteria, fungi, and viruses.
- the device is a tampon which is assembled to collect menses. After removal from the vagina, the device is separable into two or more parts having separate compartments, each with a sponge or absorbent containing the menses. The parts may then be placed, for example, in a preservative and/or fixative solution contained in vials, which are then sent to a laboratory for analysis by standard procedures, or by an automated analysis system.
- the analysis is conducted by means of the automated analysis system disclosed in U.S. Pat. No. 4,066,359, hereby incorporated by reference.
- the device of the present invention provides a means by which analysis of the menses may be accomplished simultaneously to detect vaginal cancer, sexually transmitted diseases, hepatitis B, AIDS, and other possible disease indications.
- FIG. 1 is a schematic section elevation of one possible embodiment of an apparatus for carrying out a method according to the invention
- FIG. 2 is a fragmentary illustration of the embodiment of FIG. 1;
- FIG. 3 is a longitudinal sectional illustration of a section of the embodiment of FIG. 1 after the embodiment of FIG. 1 has been separated into separate compartments;
- FIG. 4 is a cross-sectional view of the retaining compartments of the embodiment of FIG. 1 showing the retaining means;
- FIG. 5 is a schematic illustration of another possible embodiment of an apparatus for carrying out a method according to the invention.
- FIG. 6 is yet another schematic illustration of a possible embodiment of an apparatus for carrying out a method according to the invention.
- FIG. 7 is a cross-sectional view of the retaining compartments in the upper cap portion of the embodiment illustrated in FIG. 6.
- any internal body cavity where blood is encountered may be used for the purposes of the present invention.
- This cavity may be the vagina or any other cavity such as a sinus passage, the interior of the mouth, the passage leading from the ear, the anal canal, or the like.
- a device which is small enough to be comfortably received in the body cavity and retained therein while at the same time being large enough to receive and hold an amount of blood sufficient for subsequent analysis.
- the device 1 comprises a cap portion 2 and a body portion 3.
- the wall 6 can be made of any material which is compatible with the human body such as any one of a number of different metals and any one of a number of different plastics which will not soften or melt at body temperature.
- polyethylene polypropylene, polyvinylchloride, polystyrene, etc.
- a first hollow retaining compartment 8 is located within the device 1, which retaining means is capable of retaining the blood which flows into the interior portion 14 of the holder 1 through entrance 10.
- a second separate hollow retaining compartment 9 is also located within the interior portion 14 of the device 1.
- Retaining compartment 9 is structurally identical to retaining compartment 8 in the embodiment of FIG. 1. However, the separate retaining compartments 8 and 9 may be structurally different from each other if desired. Retaining compartments 8 and 9 are separated by wall 13 in FIG. 1.
- Retaining compartments 8 and 9 in the embodiment depicted in FIG. 1 have the form of a elongated tube divided into two sections which is open at one end so as to be provided with an entrance means 10 through which the blood may flow freely into the interior of the device.
- the cap portion 2 can be separated from the body portion 3 of the device 1.
- the cap portion 2 and the body portion 3 include mating flanges 4,5 where they are joined together and where they are releasably retained in connection with each other by friction or by the use of a suitable adhesive if desired.
- the cap portion 2 can be screwed onto the body portion 3.
- FIG. 3 is a longitudinal sectional illustration of a section of the embodiment of FIG. 1 after the embodiment of FIG. 1 has been separated into separate compartments and the blood which has been collected in separate compartments 8 and 9 is to be tested.
- cap portion 2 of the device separates into cap halves 2A and 2B, while body portion 3 separates into body halves 3A (which in this embodiment includes compartment 9) and 3B (which in this embodiment includes compartment 8).
- separating wall 13 comprises a first wall part 13A and a second wall part 13B.
- Body halves 3A and 3B are shown in FIG. 3 as being connectable by a projection 15 on section 3A, which fits into recess 16 on section 3B.
- Cap halves 2A and 2B can be likewise connected.
- any manner of connecting cap halves 2A and 2B, and body halves 3A and 3B, may be used.
- the retaining compartments 8 and 9 preferably include in their interior a retaining means 20 which is also compatible with the interior of a human being, in this embodiment a sponge.
- the retaining means may be in the form of a compressed body of filamentary material such as cotton wadding, or a sponge.
- a sponge instead of a sponge, another absorbent material may be used as the retaining means.
- a filamentary materials such as a compressed body of fine gold wire, since gold is known to be compatible with human beings.
- a metallic wire filament which does not have absorbent properties may be utilized, the surface tension in the blood will cause the blood to be retained at the interstices formed in the interior of the body of compressed wire, and in addition, it is to be noted that it is possible to use combinations of filamentary material such as gold wire and cotton, for example.
- Other filamentary materials may be used to form the retaining means, such as, for example, fine monofilaments of plastic.
- any plastic compatible with the human body such as nylon, polyesters, and the like, is readily available in fine filamentary form in which it can be compressed into a body held in the device 1 and forming the separate retaining compartments 8 and 9.
- FIG. 5 shows another embodiment of the device of the present invention, which may be made of any of the materials used for the embodiment shown in FIGS. 1-3.
- the device 30 comprises two body halves 31 and 32, which are connected to each other during use via protrusions 38 and corresponding recesses 39.
- Each body halve 31, 32 is further divided into upper body halves 31A, 32A and lower body halves 31B and 32B, respectively.
- the upper body halves each have a retaining compartment 36, 37 open at one end which includes a retaining means as described above for FIGS. 1-3.
- the body fluid enters the retaining compartments 36, 37 through the open ends which are directed toward the flow of the body fluid.
- the lower body halves 31B, 32B, attached to the upper body halves 31A, 32A in any manner known in the art, comprises tampons, as are conventionally used by female human being during the menstrual cycle.
- tampon sections 31B, 32B are introduced into the vagina during the menstrual cycle, and a string 33 extends from at least one of tampon sections 31B, 32B such that the device 30 can be removed from the body cavity.
- the device 40 comprises a lower body portion 41 which comprises a tampon.
- the tampon is attached to an upper cap portion 42 via a screw arrangement 47.
- the upper cap portion 42 is shown partially unscrewed from the lower body portion 41.
- the upper cap portion 42 of the embodiment depicted in FIG. 6 is divided into two detachable halves 42A and 42B.
- Each detachable half 42A, 42B includes a retaining compartment 48 and 49, respectively, separated by a wall 50, as shown in FIG. 7, having a retaining means (not shown) as described above.
- the body fluid e.g. blood
- a string 33 extends from the lower body portion 41 comprising a tampon, such that the device 30 can be removed.
- the device of the invention is inserted into a body cavity where blood will be encountered.
- the tampon is introduced into the vagina during the menstrual cycle.
- any of the devices of FIGS. 1-6 into a cavity such as the anal canal in an individual who is suffering from hemorrhoids, for example.
- the device of the invention is inserted in to the body cavity and is permitted to remain at the body cavity for a period of time which is sufficient to enable blood to flow freely into the interior of the holder of the device and to be retained by the retaining means therein.
- the device is removed from the interior of the body cavity and the blood in the device can be tested in any conventional manner.
- the two sections 8 and 9 of device 1 of FIG. 1 are removed from each other and the retaining means may be used to smear slides which can be examined under the microscope and it can be compressed in any suitable way so as to cause the liquid blood to be compressed out of the retaining means and received in any suitable container to which additional materials are added for testing purposes, as is well known.
- the blood which is squeezed from the retaining means may be received in a test tube which has in it a known reagent, and such test tubes are then capable of being placed in blood analyzing machines such as well known machines which optically analyze the blood.
- an "accessible cavity” is intended to mean a body cavity the interior of which is accessible because of the nature of the cavity, such cavities being, for example, the vagina, the mouth, the ear, the nose, the rectum, and the like, all of which are accessible without puncturing or otherwise wounding the body and all of which may at times have internal bleeding which provides a source of blood which may be used with the present invention.
- the term “accessible” is intended to cover body cavities which become accessible for reasons other than collection of blood.
- any interior part of the body which becomes accessible due to wounding of the body by accident or due to surgical procedures are also considered to be "accessible" in the sense called for by the claims inasmuch as such cavities also are sources of blood which can be collected and tested although these cavities do not become accessible for the purpose of obtaining samples of blood for testing purposes.
- An important aspect of the present invention is that, by virtue of the at least two separate compartments provided, separate samples of body fluid may be removed for different analyses simultaneously and without wounding the subject.
- a suitable additive is included in the retaining compartment as a pre-treatment for the body fluid prior to analysis.
- Such additives may be included in the retaining compartment by any means known in the art, including but not limited to being coated on the retaining means, or being embedded in the inner walls of the retaining compartment.
- a blood preservative such as citric acid is incorporated into the retaining means.
- the additive which may be contained in the retaining compartment may also comprise a suitable nutrient for suspected microorganisms, and it also may contain certain antibiotics for making certain that microorganisms in which there is n interest are killed so as not to disturb the viewing of the suspected microorganisms.
- a suitable nutrient for suspected microorganisms for example, the device when inserted into the desired accessible cavity will contact body fluids containing the microorganisms. These microorganisms will flow along with the body fluid into the retaining compartment and into the retaining means, e.g., a sponge. This sponge will absorb the liquid containing the microorganisms.
- the device of the present invention may be permitted to remain in the body cavity for as long as desired, e.g., so as to assure growth of microorganisms directly in the body cavity.
- the entire device can be removed from the body cavity in any suitable way and inspected to determine the presence or absence of microorganisms.
- This inspection may be enhanced by opening the retaining compartment and introducing into the sponge a suitable dye by way of a suitable syringe, for example, so that with this dye, the visibility of suspected microorganisms is greatly enhanced.
- monoclonal antibodies may be included in the retaining compartment, e.g. for use in the detection of the HIV virus, etc.
- the separate compartments may contain different monoclonal antibodies for the simultaneous detection of different antigens in the body.
Abstract
Description
Claims (5)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/818,637 US5247941A (en) | 1992-01-06 | 1992-01-06 | Multifunction collecting device for body fluids |
CA002086653A CA2086653A1 (en) | 1992-01-06 | 1993-01-04 | Multifunction collecting device for body fluids |
EP93400017A EP0555109A3 (en) | 1992-01-06 | 1993-01-06 | Multifunction collecting device and method for body fluids |
JP01583493A JP3338494B2 (en) | 1992-01-06 | 1993-01-06 | Body fluid sampling device |
US08/047,583 US5327897A (en) | 1992-01-06 | 1993-04-13 | Multifunction collecting device for body fluids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/818,637 US5247941A (en) | 1992-01-06 | 1992-01-06 | Multifunction collecting device for body fluids |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/047,583 Continuation US5327897A (en) | 1992-01-06 | 1993-04-13 | Multifunction collecting device for body fluids |
Publications (1)
Publication Number | Publication Date |
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US5247941A true US5247941A (en) | 1993-09-28 |
Family
ID=25226020
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/818,637 Expired - Lifetime US5247941A (en) | 1992-01-06 | 1992-01-06 | Multifunction collecting device for body fluids |
US08/047,583 Expired - Lifetime US5327897A (en) | 1992-01-06 | 1993-04-13 | Multifunction collecting device for body fluids |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/047,583 Expired - Lifetime US5327897A (en) | 1992-01-06 | 1993-04-13 | Multifunction collecting device for body fluids |
Country Status (4)
Country | Link |
---|---|
US (2) | US5247941A (en) |
EP (1) | EP0555109A3 (en) |
JP (1) | JP3338494B2 (en) |
CA (1) | CA2086653A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040241680A1 (en) * | 2001-05-21 | 2004-12-02 | Vassilios Tsilivakos | Method of determining endometrial status by tests applied on endometrial menstruation tissue (period tissue) |
US20160361208A1 (en) * | 2015-06-11 | 2016-12-15 | Werner Kasper | Device for Absorption and Controlled Discharge of Liquid Excretions |
US20180164221A1 (en) * | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
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FR2724552B1 (en) * | 1994-09-19 | 1997-04-25 | Chaffringeon Bernard | SINGLE-USE DEVICE FOR COLLECTING, AND POSSIBLY ANALYZING, A BODY LIQUID |
WO1996009545A1 (en) * | 1994-09-22 | 1996-03-28 | Bernard Chaffringeon | Single-use device for detecting or analyzing a body fluid |
GB2349573B (en) * | 1996-05-17 | 2000-12-27 | A Fem Medical Corp | Method for collecting vaginal fluid and exfoliated vaginal cells for diagnostic purposes |
US5971942A (en) * | 1996-12-03 | 1999-10-26 | Gu; Howard H. | Intestinal fluid sampler |
US6423883B1 (en) | 1999-07-13 | 2002-07-23 | Kimberly-Clark Worldwide, Inc. | Liquid reception medium with liquid activated mechanical mass transport means |
US6583722B2 (en) | 2000-12-12 | 2003-06-24 | Kimberly-Clark Worldwide, Inc. | Wetness signaling device |
US6603403B2 (en) | 2000-12-12 | 2003-08-05 | Kimberly-Clark Worldwide, Inc. | Remote, wetness signaling system |
US7294138B2 (en) * | 2004-06-28 | 2007-11-13 | Shippert Ronald D | Nose pack method and apparatus |
EP1954197A2 (en) * | 2005-11-22 | 2008-08-13 | Stichting Top Institute Food and Nutrition | Sampling device for in vivo sampling of liquids from the gastrointestinal tract, process for the production thereof and mould or mask for use in the production process |
US20110270127A1 (en) * | 2006-09-18 | 2011-11-03 | Shany Vered | Biological Fluid Receptacle |
US8157747B2 (en) * | 2008-02-15 | 2012-04-17 | Lary Research & Development, Llc | Single-use indicator for a surgical instrument and a surgical instrument incorporating same |
US8604267B2 (en) * | 2008-06-09 | 2013-12-10 | Merrie K. East | Disposable nose pack for nosebleeds |
US20130006148A1 (en) * | 2010-03-15 | 2013-01-03 | Takahito Matumura | Vacuum blood collection tube, blood collection unit and device for discriminating test methods |
JP2017529199A (en) * | 2014-08-12 | 2017-10-05 | ネクストジェン ジェイン, インコーポレイテッド | System and method for monitoring health based on collected body fluid |
US20160073937A1 (en) * | 2014-09-11 | 2016-03-17 | Becton, Dickinson And Company | Blood sampling system for improving draw success and reducing hemolysis |
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US5002540A (en) * | 1989-05-22 | 1991-03-26 | Warren Kirschbaum | Intravaginal device and method for delivering a medicament |
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- 1993-01-04 CA CA002086653A patent/CA2086653A1/en not_active Abandoned
- 1993-01-06 JP JP01583493A patent/JP3338494B2/en not_active Expired - Fee Related
- 1993-01-06 EP EP93400017A patent/EP0555109A3/en not_active Withdrawn
- 1993-04-13 US US08/047,583 patent/US5327897A/en not_active Expired - Lifetime
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040241680A1 (en) * | 2001-05-21 | 2004-12-02 | Vassilios Tsilivakos | Method of determining endometrial status by tests applied on endometrial menstruation tissue (period tissue) |
US20160361208A1 (en) * | 2015-06-11 | 2016-12-15 | Werner Kasper | Device for Absorption and Controlled Discharge of Liquid Excretions |
US9993371B2 (en) * | 2015-06-11 | 2018-06-12 | Werner Kasper | Device for absorption and controlled discharge of liquid excretions |
US20180164221A1 (en) * | 2016-12-07 | 2018-06-14 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
US11547301B2 (en) | 2016-12-07 | 2023-01-10 | Biora Therapeutics, Inc. | Methods for collecting and testing bacteria containing samples from within the gastrointestinal tract |
Also Published As
Publication number | Publication date |
---|---|
EP0555109A2 (en) | 1993-08-11 |
EP0555109A3 (en) | 1995-08-09 |
CA2086653A1 (en) | 1993-07-07 |
JPH067328A (en) | 1994-01-18 |
US5327897A (en) | 1994-07-12 |
JP3338494B2 (en) | 2002-10-28 |
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