US5244636A - Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample - Google Patents
Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample Download PDFInfo
- Publication number
- US5244636A US5244636A US07/645,787 US64578791A US5244636A US 5244636 A US5244636 A US 5244636A US 64578791 A US64578791 A US 64578791A US 5244636 A US5244636 A US 5244636A
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- United States
- Prior art keywords
- optic array
- light energy
- fiber optic
- discrete
- fiber
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/02—Optical fibres with cladding with or without a coating
- G02B6/02042—Multicore optical fibres
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/04—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres
- G02B6/06—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings formed by bundles of fibres the relative position of the fibres being the same at both ends, e.g. for transporting images
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6434—Optrodes
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N2021/7706—Reagent provision
- G01N2021/773—Porous polymer jacket; Polymer matrix with indicator
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7786—Fluorescence
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7793—Sensor comprising plural indicators
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/3616—Holders, macro size fixtures for mechanically holding or positioning fibres, e.g. on an optical bench
- G02B6/3624—Fibre head, e.g. fibre probe termination
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/3628—Mechanical coupling means for mounting fibres to supporting carriers
- G02B6/3632—Mechanical coupling means for mounting fibres to supporting carriers characterised by the cross-sectional shape of the mechanical coupling means
- G02B6/3644—Mechanical coupling means for mounting fibres to supporting carriers characterised by the cross-sectional shape of the mechanical coupling means the coupling means being through-holes or wall apertures
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/3628—Mechanical coupling means for mounting fibres to supporting carriers
- G02B6/3648—Supporting carriers of a microbench type, i.e. with micromachined additional mechanical structures
- G02B6/3652—Supporting carriers of a microbench type, i.e. with micromachined additional mechanical structures the additional structures being prepositioning mounting areas, allowing only movement in one dimension, e.g. grooves, trenches or vias in the microbench surface, i.e. self aligning supporting carriers
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
- G02B6/24—Coupling light guides
- G02B6/36—Mechanical coupling means
- G02B6/3628—Mechanical coupling means for mounting fibres to supporting carriers
- G02B6/3664—2D cross sectional arrangements of the fibres
- G02B6/3672—2D cross sectional arrangements of the fibres with fibres arranged in a regular matrix array
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- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Optics & Photonics (AREA)
- Plasma & Fusion (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
Description
TABLE I ______________________________________ Excitation Wavelength Fluorescence (range emission range Compounds or λ maximum) (λ max) ______________________________________ A. Fluorophores Eosin 470-530 nm 530-580 nm (550 nm) TRITC-amine 555 nm 570-610 nm (590 nm) Quinine 330-352 nm 382-450 nm Fluorescein 488-496 nm 530 nm Acridine yellow 464 nm 500 nm Lissamine Rhodamine 567 nm 580 nm B Sulfonyl Chloride Erythroscein 504 nm 560 nm Ruthenium (tris, bipyridium) 460 nm 580 nm Texas Red Sulfonyl Chloride 596 nm 615 nm B-phycoerythrin 545,565 nm 575 nm Nicotinamide adenine 340 nm 435 nm dinucleotide (NADH) Flavin adenine 450 nm 530 nm dinucleotide (FAD) Carboxy Seminaphthorhoda- 587 nm 640 nm fluor Naphthofluorescein 594 nm 663 nm B. Fluorescent Enzyme Substrates Fluorescein 452 nm 518 nm mono-B-D-galactopyranoside Resorufin B-D-glucuronide 468 nm 584 nm 8-acetoxypyrene- 368 nm 391 nm 1,3,6-trisulfonic acid trisodium salt Coenzyme A 339 nm 377 nm (1-pyrene butanoic acid)ester Fluo-3; free acid [Molecular 506 nm 526 nm Probes, Eugene, CA] Quin-2, tetrapotassium 352 nm 492 nm C. Fluorescent Antibody Conjugates Texas Red goat anti-mouse 590 nm 615 nm FgG conjugates Protein A fluorescein 480 nm 520 nm conjugates Anti-Atrazine fluorescein 480 nm 520 nm conjugates Anti-digoxin Texas Red 590 nm 615 nm conjugates ______________________________________
TABLE II ______________________________________ Energy Absorbance Chromophores Range (λ max) ______________________________________ Iron-salicylate complex 530 nm Indamine dye 590 nm INT formazon dye Hopkins-Cole dye 560 nm Quinone-imine dye 500 nm Fe(SCN).sup.+2 460 nm Malachite Green 620 nm 4-bromo A-23187, free acid 340 nm Cresol red 415 nm, acid; 570 nm, base Phenolphthalein 600 nm Oxine blue 450 nm, acid; 600 nm, base diphenylcarbazone 575 nm disulphonic acid Chrome bordeaux B 575 nm Calmagite 650 nm Ninhydrin dye 650 nm ______________________________________
TABLE III ______________________________________ A. Monomers acrylamide N,N - methylene bis(acrylamide) hydroxyethylmethacrylate styrene vinyl acetate N-(3-aminopropyl) meth-acrylamide hydrochloride [Kodak, Inc.] B. Comonomer with dimethylsiloxane (acryloxypropyl) methyl (15-20%) (aminopropyl) methyl (3-5%) (methacryloxypropyl) methyl (2-3%) C. T-structure polydimethylsiloxanes methacryloxypropyl (25-50%) vinyl (50-75%) ______________________________________
TABLE IV ______________________________________ Conjugated dye ______________________________________ acryloyl fluorescein acryloyl rhodamine acryloyl eosin phenol red acryloyl g-hydroxypyrene 1,3 disulfonic acid acryloyl seminaphthorhodafluor acryloyl seminaphthofluorescein ______________________________________
Claims (15)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/645,787 US5244636A (en) | 1991-01-25 | 1991-01-25 | Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample |
US07/870,949 US5244813A (en) | 1991-01-25 | 1992-04-20 | Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample |
US07/981,884 US5320814A (en) | 1991-01-25 | 1992-11-25 | Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample |
US07/994,552 US5250264A (en) | 1991-01-25 | 1992-12-21 | Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/645,787 US5244636A (en) | 1991-01-25 | 1991-01-25 | Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/870,949 Continuation-In-Part US5244813A (en) | 1991-01-25 | 1992-04-20 | Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample |
US07/981,884 Continuation-In-Part US5320814A (en) | 1991-01-25 | 1992-11-25 | Fiber optic array sensors, apparatus, and methods for concurrently visualizing and chemically detecting multiple analytes of interest in a fluid sample |
US07/994,552 Continuation US5250264A (en) | 1991-01-25 | 1992-12-21 | Method of making imaging fiber optic sensors to concurrently detect multiple analytes of interest in a fluid sample |
Publications (1)
Publication Number | Publication Date |
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US5244636A true US5244636A (en) | 1993-09-14 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/645,787 Expired - Lifetime US5244636A (en) | 1991-01-25 | 1991-01-25 | Imaging fiber optic array sensors, apparatus, and methods for concurrently detecting multiple analytes of interest in a fluid sample |
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US (1) | US5244636A (en) |
Cited By (191)
Publication number | Priority date | Publication date | Assignee | Title |
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US5298741A (en) * | 1993-01-13 | 1994-03-29 | Trustees Of Tufts College | Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample |
WO1994012863A1 (en) * | 1992-11-25 | 1994-06-09 | Trustees Of Tufts College | Fiber optic array sensors and methods for concurrently visualizing and chemically detecting multiple analytes in a fluid |
US5353792A (en) * | 1992-09-25 | 1994-10-11 | Avl Medical Instruments Ag | Sensing device |
US5512490A (en) * | 1994-08-11 | 1996-04-30 | Trustees Of Tufts College | Optical sensor, optical sensing apparatus, and methods for detecting an analyte of interest using spectral recognition patterns |
US5530779A (en) * | 1993-07-06 | 1996-06-25 | Consiglio Nazionale Delle Ricerche | Method and apparatus for the immobilization of vitreous supports at the ends of plastic or glass optical fibers for the construction of fiber-optic chemical sensor |
WO1997027326A1 (en) * | 1996-01-26 | 1997-07-31 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5690894A (en) * | 1995-05-23 | 1997-11-25 | The Regents Of The University Of California | High density array fabrication and readout method for a fiber optic biosensor |
US5774603A (en) * | 1996-03-02 | 1998-06-30 | Eastman Kodak Company | Optical chemical sensor |
US5814524A (en) * | 1995-12-14 | 1998-09-29 | Trustees Of Tufts College | Optical sensor apparatus for far-field viewing and making optical analytical measurements at remote locations |
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