US5133351A - Low-frequency electrotherapeutic device - Google Patents

Low-frequency electrotherapeutic device Download PDF

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US5133351A
US5133351A US07/492,230 US49223090A US5133351A US 5133351 A US5133351 A US 5133351A US 49223090 A US49223090 A US 49223090A US 5133351 A US5133351 A US 5133351A
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low
voltage
frequency
voltage component
electrode
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Kazumi Masaki
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/044Shape of the electrode
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/322Electromedical brushes, combs, massage devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/0404Electrodes for external use
    • A61N1/0408Use-related aspects
    • A61N1/0428Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432Anode and cathode
    • A61N1/0436Material of the electrode

Definitions

  • the present invention relates to a low-frequency electrotherapeutic device, specifically, to that wherein its low-frequency voltage has a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1.
  • a low-frequency voltage In a massotherapy wherein a low-frequency voltage is applied to human body, it is recommendable to use a low-frequency voltage with a sharp waveform consisting of a rapid rise and a slow fall.
  • Low-frequency voltages with a logarithmic or square waveform have been frequently used in the past because they fulfill these requirements.
  • the low-frequency voltages may achieve a satisfactory efficacy when their duration conforms to the chronaxy of the muscle being treated, but frequently lead to a painful unsatisfactory treatment because the chronaxy greatly varies with individual sites in a human body.
  • the present inventor found that an extremely efficacious massotherapy can be attained without causing unwanted pain when the ratio is in the range of about 0.1:1-0.5:1.
  • the present invention relates to a low-frequency electrotherapeutic device to apply a low-frequency voltage to a human body, characterized in that said low-frequency voltage has a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1.
  • FIG. 1 is the circuit of an embodiment according to the invention
  • FIGS. 2a -2f are the waveforms appearing in the circuit
  • FIG. 3 is the circuit of another embodiment according to the invention.
  • FIG. 4 is the vertical side elevation view of an electrode using a pressure-sensitive resistor
  • FIG. 5 is the plane view of the electrode
  • FIG. 6 graphically shows the relationship between the pressure to a pressure-sensitive resistor and its electric resistance
  • FIG. 7 is the vertical side elevation view of a variable resistor using a pressure-sensitive resistor:
  • FIG. 8 is the plane view of a plug/socket combination for the connection of electrode.
  • FIGS. 9 and 10 are the vertical side elevation views of an electrode which serves as an active and a dispersive electrodes.
  • R 1 -R 10 designate resistors; C 1 -C 6 , capacitors; Tr 1 -Tr 4 , transistors; T, transformer; L 1 and L 2 , windings; VR, variable resistor; Osc 1 and Osc 2 , multivibrators; S, switch; reference numeral 1, cover member; 2, sponge member; 3, metal plate; 4, pressure-sensitive resistor; 5, insulating material; 6, guide; 7, lead; 8, basal plate; 9, fulcrum; 10, leaf spring member; 11, 2P plug: and 12, 2P socket.
  • a blocking oscillator comprising transistor Tr 1 and transformer T is to generate a pulsating voltage that has a diphasic action potential waveform with a ratio of positive component E 1 to negative component E 2 in the range of about 0.1:1-0.5:1, as shown in FIG. 2(a).
  • the diphasic action potential a pulsating voltage found in a stimulated nerve, consists of a pair of positive voltage and negative voltage components both having a sharp spike.
  • the aforementioned blocking oscillator is to generate by electronic circuitry the diphasic action potential that is usually found only in a stimulated nerve.
  • capacitors C 1 and C 2 connected with primary winding L 1 of transformer T, resistors R 1 , R 2 and R 3 , and variable resistor VR are to control the ratio of positive voltage component E 1 to negative voltage component E 2 in the diphasic action potential, as well as to control its pulse interval.
  • a low-frequency voltage that is advantageously usable in massotherapy can be obtained by controlling the values of the capacitors and resistors to give a ratio of positive voltage component E 1 to negative voltage component E 2 in the range of about 0.1:1-0.5:1, preferably, about 0.2:1-0.3:1.
  • pulse duration t 2 of negative voltage component E 2 in one pulsating wave is set in the range of about 0.001-0.01 second, preferably, about 0.002-0.005 seconds, while duration t 1 of positive voltage component E 1 is brought to from 1.1- to 2.0-folds, preferably, from about 1.4- to 1.6-folds of duration t 2 .
  • the present inventor tested various pulsating voltages including diphasic action potential-, square- and logarithmic-waves on their ratio of positive voltage component to negative voltage component, as well as on their massaging and side effects.
  • the test revealed that a ratio lower than about 0.1:1 or higher than about 0.5:1 did not attain a desired massaging effect instead unwanted side effects such as pain and drying of the skin arose.
  • the pulse interval of a treatment voltage across electrodes P and E can be increased and decreased at prescribed time intervals by taking advantage of an intrinsic property a blocking oscillator, so that the response to the treatment voltage in the affected site never decreases or weakens to an undesirable level.
  • the intrinsic property is that the pulse interval in an output from the blocking oscillator greatly varies with the base voltage of transistor Tr 1 : A relatively high base voltage leads to a shortened pulse interval, while a relatively low base voltage leads to an elongated pulse interval.
  • an output terminal of multivibrator Osc 1 generating a square wave with a relatively short period as shown in FIG. 2(b) is connected with an input terminal of multivibrator Osc 2 that generates a square wave with a relatively long period as shown in FIG. 2(c).
  • An output terminal of multivibrator Osc 2 is connected with an input terminal of an emitter follower comprising transistor Tr 2 and exhibiting a time constant.
  • An output terminal of the emitter follower is connected with the base of transistor Tr 1 in the aforementioned blocking oscillator through resistor R 2 .
  • An output of multivibrator Osc 1 is supplied to the base of transistor Tr 1 in the blocking oscillator through resistor R 3 and an emitter follower comprising shaper transistor Tr 3 and transistor Tr 4 and exhibiting a time constant.
  • the pulse interval is usually set to 1-200 hertz in terms of its period.
  • pulse interval closely relates to the refractory period in electrotherapy.
  • the frequency that is stimulative to human body is dependent on the refractory period, and the upper limit of such frequency is usually found in the range of 400-2,000 hertz. It was confirmed that a pulsating voltage having a pulse interval in the above range exerts the possible highest efficacy when used in this embodiment.
  • the pulse interval of the blocking oscillator can be stepwise or non-stepwise increased and decreased at prescribed time intervals by controlling the operation of transistor Tr 2 with switch S.
  • switch S multivibrator Osc 1
  • the emitter follower comprising shaper transistor Tr 3 and transistor Tr 4 in FIG. 1 may be omitted to simplify the overall arrangement of the embodiment.
  • a pulsating voltage that increases and decreases through two or three steps at appropriate time intervals, for example, of 0.5-5 seconds, preferably, 1-2 seconds, a much more comfortable massotherapy is achievable with causing much less pain than in the case of applying a low-frequency voltage wherein a pulsating voltage as shown in FIG. 2(a), 2(e) or 2(f) repeatedly appears at the same time intervals.
  • Such massotherapy is more effective in promoting the metabolism of the skin.
  • Electrodes P and E Conventional electrodes can be used as electrodes P and E. If an inadequately controlled treatment voltage is applied to the patient's body, the patient may experience the discomfort in the form of an electric shock when active electrode P is brought into contact with the patient's skin. Because of this reason, it is recommendable to choose electrodes free of such disadvantage.
  • FIG. 3 is the circuit of another embodiment according to the invention.
  • a blocking oscillator comprising transistor Tr 4 and transformer T is to generate a pulsating voltage that has a diphasic action potential waveform with a ratio of positive voltage component E 1 to negative voltage component E 2 in the range of about 0.1:1-0.5:1, as shown in FIG. 2(a).
  • both capacitor C 6 connected with primary winding L 1 of transformer T in the blocking oscillator, and resistor R 10 connected with secondary winding L 2 of transformer T are provided to control the pulse width of the pulsating voltage, as well as to control its ratio of positive voltage component E 1 to negative voltage component E 2 .
  • the ratio can be set to about 0.1:1-0.5:1, preferably, about 0.2:1-0.3:1.
  • pulse duration t 2 of negative voltage component E 2 in one pulsating wave can be set to about 0.001-0.01 second, preferably, about 0.002-0.005 seconds, while duration t 1 of positive voltage component E 1 is set to from about 1.1- to about 2.0-folds, preferably, from about 1.4- to about 1.6-folds of duration t 2 .
  • the treatment voltage thus obtained is advantageously usable in massotherapy.
  • an output terminal of a multivibrator which comprises transistors Tr 1 and Tr 2 and generates a square wave as shown in FIG. 2(c) is connected with an input terminal of an emitter follower that comprises transistor Tr 3 and exhibits a time constant.
  • An output terminal of the emitter follower is connected with the base of transistor Tr 4 in the aforementioned blocking oscillator.
  • the pulse interval in one train is appropriately set in the range having an upper limit, usually, of 400-2,000 hertz, similarly as in the preceding embodiment.
  • the ratio of positive voltage component to negative voltage component in a treatment voltage is controlled by changing the Q value of the resonant circuit including transformer T.
  • a desired voltage ratio can be easily attained, for example, by connecting a diode and a resistor, preferably, a series circuit of a diode and a variable resistor, between electrodes P and E in a forward direction with respect to the power source being connected, and changing the value of the variable resistor to increase or decrease the positive voltage component.
  • the present low-frequency electrotherapeutic device can be used to iontophorese medicaments, as well as to conduct massotherapy.
  • the low-frequency electrotherapeutic device of the invention since the low-frequency electrotherapeutic device of the invention generates a low-frequency voltage having a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1, in other words, a low-frequency voltage having negative voltage component larger in magnitude than positive voltage component, the device can be advantageously used to iontophorese medicaments which negatively charge in solution, such as acetic acid, kojic acid and vitamin C. Such iontophoresis is very effective in treating or removing dermatophytosis and deposited pigments.
  • a low-frequency voltage having a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1 scarcely causes discomfort, pain, inflammation or burns when applied to the skin, it comfortably and efficiently iontophoreses medicaments which positively charge in solution, for example, aminovinyl photosensitizing dyes when such low-frequency voltage, preferably, that having a diphasic action potential waveform, frequency, for example, of about 0.1-10 hertz, preferably, about 0.5-5 hertz, is superposed on a square wave voltage without negative voltage component.
  • a square wave having a frequency of about 0.1-10 hertz, preferably, about 0.5-5 hertz, is used as the power source, for example, for a blocking oscillator generating a low-frequency voltage with a diphasic action potential waveform, while another square wave that is different in phase from the former square wave, frequency, for example, of about 0.1-10 hertz, preferably, about 0.5-5 hertz, is applied across electrodes P and E in such manner that the low-frequency voltage and a dc voltage without positive or negative voltage component are successively applied to the electrodes at the period of the square wave; or that a low-frequency voltage having a diphasic action potential waveform with a slightly long pulse interval is superposed on the dc voltage.
  • a massaging effect of the present device and a pharmaceutically effective component iontophoresed in the deeper part of the skin synergistically cooperate to give an extremely high efficacy.
  • FIGS. 4 and 5 are illustrative of an electrode which serves as a variable resistor as well, wherein metal plate (3), pressure-sensitive resistor (4), metal plate (3'), insulating member (5) and metal plate (3") are prepared into one body by laminating them in layers between sponge member (2) and curved plastic cover member (1) bearing guide (6) so that the user can handle the electrode.
  • Metal plates (3') and (3") are electrically connected each other, and lead (7) is connected to metal plate (3).
  • Pressure-sensitive resistor (4) has the feature that its electric resistance is relatively high at ambient pressure but decreases as shown in FIG. 6 when pressured.
  • the user connects the electrode with an output terminal of the circuit shown in FIG. 1 or 3, inserts the hand in guide (6), and places on the skin sponge member (2) which has been soaked in water or an aqueous electrolyte solution.
  • the magnitude of a treatment voltage across the skin can be finely controlled by increasing or decreasing the pressure to the electrode while allowing sponge member (2) to contact with the skin.
  • FIG. 7 is illustrative of a variable resistor using a pressure-sensitive resistor, which is advantageously usable as variable resistor VR in the circuit shown in FIG. 1 or 3.
  • metal plate (3) bearing lead (7) is attached to insulating basal plate (8), while pressure-sensitive resistors (4)(4') are attached to metal plate (3) through (9) to leave an appropriate spacing.
  • Insulating cover member (1) is placed over pressure-sensitive resistors (4)(4') through metal plates (3')(3") having lead (7')(7") respectively, while one end of cover member (1) is elastically fixed to basal plate (8) with leaf spring (10).
  • pressure-sensitive resistor (4) located at the side pressured by leaf spring member (10) exhibits a relatively low resistance
  • pressure-sensitive resistor (4') located at the side without pressure exhibits a relative high resistance
  • the magnitude of a treatment voltage across leads (7)(7') or leads (7)(7") can be adequately controlled by increasing or decreasing the pressure to pressure-sensitive resistor (4') through cover member (1) to change the electric resistance of pressure-sensitive resistors (4)(4') with respect to fulcrum (9).
  • Leads (7)(7') or leads (7)(7") and an output terminal of a low-frequency oscillator can be conveniently interconnected by using a pair of 2P plug (11) and 2P socket (12) as shown in FIG. 8 wherein the size of plugs is changed in accordance with polarity.
  • the user by further changing the distance between the plugs in accordance with the magnitude of the voltage to be applied, the user neither applies a high voltage to the site to be applied with a low voltage nor connects a plug to a socket with wrong polarity.
  • FIG. 9 is illustrative of an electrode arrangement which serves as an active and a dispersive electrodes.
  • Metal plates (3)(3') bearing leads (7)(7') respectively are tightly placed between the upper and lower sides of insulating basal plate (8) which has been attached with guide (6) so that the user can handle the electrode. It is recommendable to prepare the electrode into a curved shape in order to ensure a better fitness to the affected site, similarly as in the case of the electrode shown in FIG. 4.
  • the electrode is connected with an output terminal of the circuit shown in FIG. 1 or 3, and sponge members (2)(2') are immersed in water or an electrolyte solution, after which the user inserts the hand in guide (6) and places sponge member (2') on the affected site.
  • the electrode has the features that it enables an efficient therapy of various sites in human body because the user connects only one electrode to a low-frequency electrotherapeutic device and handles the electrode during therapy.
  • metal plate (3") is additionally provided on the upper surface of guide (6) in the electrode shown in FIG. 9, and then electrically connected with lead (7).
  • the electrode has the feature that it reduces electric shock to the hand in contact with the electrode because, when used, for example, in bath, a major part of current flows through an electric resistance that is formed between metal plate (3") and the human body through water.
  • An active and a dispersive electrode can be connected into one body by attaching a pair of half circular metal plate bearing a lead to a base plate of an insulating material shaped, for example, into triangle, square or circle while electrically insulating the metal plates, and covering the metal plates with a sponge member in the same shape; or concentrically attaching to the basal plate a ring-shaped metal plate having a lead and a ring- or disc-shaped metal plate bearing a lead to leave an appropriate spacing, and covering the metal plates with a sponge member of the same shape.
  • An active electrode prepared, for example, into a roller shape can be rotatably attached to one end of a vessel containing a low-frequency electrotherapeutic device, while the peripheral part of the vessel to be handled can be covered with a band-shaped dispersive electrode.
  • massotherapy using the present electrotherapeutic device helps to promote the metabolism of the scalp. This is effective in promoting the regeneration and growth of hair, as well as in preventing the loss of hair and keeping its health.
  • the electrotherapeutic device of the invention has the feature that it enables a comfortable iontophoresis without fear of causing pain, inflammation or burn.

Abstract

A novel low-frequency electrotherapeutic device wherein a low-frequency voltage having a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1 is used. The electrotherapeutic device can be advantageously used to massage human body or to iontophorese medicament thereinto without causing unwanted discomforts such as pain, inflammation and burning which are inevitable in conventional low-frequency electrotherapy.

Description

This application is a continuation of application Ser. No. 07/223,547, filed Aug. 18, 1988 now abandoned.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a low-frequency electrotherapeutic device, specifically, to that wherein its low-frequency voltage has a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1.
2. Description of the Prior Art
In a massotherapy wherein a low-frequency voltage is applied to human body, it is recommendable to use a low-frequency voltage with a sharp waveform consisting of a rapid rise and a slow fall. Low-frequency voltages with a logarithmic or square waveform have been frequently used in the past because they fulfill these requirements.
The low-frequency voltages may achieve a satisfactory efficacy when their duration conforms to the chronaxy of the muscle being treated, but frequently lead to a painful unsatisfactory treatment because the chronaxy greatly varies with individual sites in a human body.
SUMMARY OF THE INVENTION
With the viewpoint that a ratio of positive voltage component to negative component is an important factor for low-frequency treatment voltage, the present inventor investigated various means wherein these drawbacks of conventional low-frequency electrotherapeutic device are greatly reduced or even eliminated.
As the result, the present inventor found that an extremely efficacious massotherapy can be attained without causing unwanted pain when the ratio is in the range of about 0.1:1-0.5:1.
More particularly, the present invention relates to a low-frequency electrotherapeutic device to apply a low-frequency voltage to a human body, characterized in that said low-frequency voltage has a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1.
BRIEF DESCRIPTION OF THE DRAWINGS
The present invention will hereinafter be explained in detail with reference to the accompanying drawings, in which:
FIG. 1 is the circuit of an embodiment according to the invention;
FIGS. 2a -2f are the waveforms appearing in the circuit;
FIG. 3 is the circuit of another embodiment according to the invention;
FIG. 4 is the vertical side elevation view of an electrode using a pressure-sensitive resistor;
FIG. 5 is the plane view of the electrode;
FIG. 6 graphically shows the relationship between the pressure to a pressure-sensitive resistor and its electric resistance;
FIG. 7 is the vertical side elevation view of a variable resistor using a pressure-sensitive resistor:
FIG. 8 is the plane view of a plug/socket combination for the connection of electrode; and
FIGS. 9 and 10 are the vertical side elevation views of an electrode which serves as an active and a dispersive electrodes.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
Throughout the drawings, symbols R1 -R10 designate resistors; C1 -C6, capacitors; Tr1 -Tr4, transistors; T, transformer; L1 and L2, windings; VR, variable resistor; Osc1 and Osc2, multivibrators; S, switch; reference numeral 1, cover member; 2, sponge member; 3, metal plate; 4, pressure-sensitive resistor; 5, insulating material; 6, guide; 7, lead; 8, basal plate; 9, fulcrum; 10, leaf spring member; 11, 2P plug: and 12, 2P socket.
In the circuit as shown in FIG. 1, a blocking oscillator comprising transistor Tr1 and transformer T is to generate a pulsating voltage that has a diphasic action potential waveform with a ratio of positive component E1 to negative component E2 in the range of about 0.1:1-0.5:1, as shown in FIG. 2(a).
The diphasic action potential, a pulsating voltage found in a stimulated nerve, consists of a pair of positive voltage and negative voltage components both having a sharp spike. The aforementioned blocking oscillator is to generate by electronic circuitry the diphasic action potential that is usually found only in a stimulated nerve.
In the blocking oscillator, capacitors C1 and C2 connected with primary winding L1 of transformer T, resistors R1, R2 and R3, and variable resistor VR are to control the ratio of positive voltage component E1 to negative voltage component E2 in the diphasic action potential, as well as to control its pulse interval. A low-frequency voltage that is advantageously usable in massotherapy can be obtained by controlling the values of the capacitors and resistors to give a ratio of positive voltage component E1 to negative voltage component E2 in the range of about 0.1:1-0.5:1, preferably, about 0.2:1-0.3:1. In the same way, pulse duration t2 of negative voltage component E2 in one pulsating wave is set in the range of about 0.001-0.01 second, preferably, about 0.002-0.005 seconds, while duration t1 of positive voltage component E1 is brought to from 1.1- to 2.0-folds, preferably, from about 1.4- to 1.6-folds of duration t2 .
The present inventor tested various pulsating voltages including diphasic action potential-, square- and logarithmic-waves on their ratio of positive voltage component to negative voltage component, as well as on their massaging and side effects. The test revealed that a ratio lower than about 0.1:1 or higher than about 0.5:1 did not attain a desired massaging effect instead unwanted side effects such as pain and drying of the skin arose.
In this embodiment, the pulse interval of a treatment voltage across electrodes P and E can be increased and decreased at prescribed time intervals by taking advantage of an intrinsic property a blocking oscillator, so that the response to the treatment voltage in the affected site never decreases or weakens to an undesirable level. The intrinsic property is that the pulse interval in an output from the blocking oscillator greatly varies with the base voltage of transistor Tr1 : A relatively high base voltage leads to a shortened pulse interval, while a relatively low base voltage leads to an elongated pulse interval.
More particularly, an output terminal of multivibrator Osc1 generating a square wave with a relatively short period as shown in FIG. 2(b) is connected with an input terminal of multivibrator Osc2 that generates a square wave with a relatively long period as shown in FIG. 2(c). An output terminal of multivibrator Osc2 is connected with an input terminal of an emitter follower comprising transistor Tr2 and exhibiting a time constant. An output terminal of the emitter follower is connected with the base of transistor Tr1 in the aforementioned blocking oscillator through resistor R2. An output of multivibrator Osc1 is supplied to the base of transistor Tr1 in the blocking oscillator through resistor R3 and an emitter follower comprising shaper transistor Tr3 and transistor Tr4 and exhibiting a time constant.
By this arrangement, when both multivibrators Osc1 and Osc2 are out of operation, voltage e1 shown in FIG. 2(d) is applied to the base of transistor Tr1 from a power source; when only multivibrator Osc1 is in operation, voltage e2, which is higher than voltage e1, is applied to the base; when both multivibrators Osc1 and Osc2 are in operation, much higher voltage e3 is applied to the base. When the voltage across the base stepwise elevates in this manner, the pulse interval of an output from the blocking oscillator stepwise shortens as shown in FIGS. 2(a), 2(e) and 2(f) in the given order.
The pulse interval is usually set to 1-200 hertz in terms of its period. Generally, pulse interval closely relates to the refractory period in electrotherapy. Thus, the frequency that is stimulative to human body is dependent on the refractory period, and the upper limit of such frequency is usually found in the range of 400-2,000 hertz. It was confirmed that a pulsating voltage having a pulse interval in the above range exerts the possible highest efficacy when used in this embodiment.
Since in this embodiment switch S is inserted in a collector circuit including transistor Tr2, the pulse interval of the blocking oscillator can be stepwise or non-stepwise increased and decreased at prescribed time intervals by controlling the operation of transistor Tr2 with switch S.
In case that the pulse interval of the blocking oscillator is non-stepwise increased and decreased at prescribed time intervals, switch S, multivibrator Osc1, and the emitter follower comprising shaper transistor Tr3 and transistor Tr4 in FIG. 1 may be omitted to simplify the overall arrangement of the embodiment.
By applying a human body a pulsating voltage that increases and decreases through two or three steps at appropriate time intervals, for example, of 0.5-5 seconds, preferably, 1-2 seconds, a much more comfortable massotherapy is achievable with causing much less pain than in the case of applying a low-frequency voltage wherein a pulsating voltage as shown in FIG. 2(a), 2(e) or 2(f) repeatedly appears at the same time intervals. Such massotherapy is more effective in promoting the metabolism of the skin.
Conventional electrodes can be used as electrodes P and E. If an inadequately controlled treatment voltage is applied to the patient's body, the patient may experience the discomfort in the form of an electric shock when active electrode P is brought into contact with the patient's skin. Because of this reason, it is recommendable to choose electrodes free of such disadvantage.
FIG. 3 is the circuit of another embodiment according to the invention.
In the circuit, a blocking oscillator comprising transistor Tr4 and transformer T is to generate a pulsating voltage that has a diphasic action potential waveform with a ratio of positive voltage component E1 to negative voltage component E2 in the range of about 0.1:1-0.5:1, as shown in FIG. 2(a).
More particularly, both capacitor C6 connected with primary winding L1 of transformer T in the blocking oscillator, and resistor R10 connected with secondary winding L2 of transformer T are provided to control the pulse width of the pulsating voltage, as well as to control its ratio of positive voltage component E1 to negative voltage component E2. By changing the values of the resistor and capacitor to control the Q value of a resonant circuit including transformer T, the ratio can be set to about 0.1:1-0.5:1, preferably, about 0.2:1-0.3:1. In the same way, pulse duration t2 of negative voltage component E2 in one pulsating wave can be set to about 0.001-0.01 second, preferably, about 0.002-0.005 seconds, while duration t1 of positive voltage component E1 is set to from about 1.1- to about 2.0-folds, preferably, from about 1.4- to about 1.6-folds of duration t2. The treatment voltage thus obtained is advantageously usable in massotherapy.
In this embodiment, an output terminal of a multivibrator which comprises transistors Tr1 and Tr2 and generates a square wave as shown in FIG. 2(c) is connected with an input terminal of an emitter follower that comprises transistor Tr3 and exhibits a time constant. An output terminal of the emitter follower is connected with the base of transistor Tr4 in the aforementioned blocking oscillator. By supplying the square wave to the blocking oscillator through the emitter follower to bias the base of transistor Tr4, a train of pulsating voltage having a diphasic action potential waveform is intermittently energized across electrodes P and E.
In this case, the pulse interval in one train is appropriately set in the range having an upper limit, usually, of 400-2,000 hertz, similarly as in the preceding embodiment.
In this embodiment, the ratio of positive voltage component to negative voltage component in a treatment voltage is controlled by changing the Q value of the resonant circuit including transformer T. A desired voltage ratio can be easily attained, for example, by connecting a diode and a resistor, preferably, a series circuit of a diode and a variable resistor, between electrodes P and E in a forward direction with respect to the power source being connected, and changing the value of the variable resistor to increase or decrease the positive voltage component.
The present low-frequency electrotherapeutic device can be used to iontophorese medicaments, as well as to conduct massotherapy.
More particularly, since the low-frequency electrotherapeutic device of the invention generates a low-frequency voltage having a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1, in other words, a low-frequency voltage having negative voltage component larger in magnitude than positive voltage component, the device can be advantageously used to iontophorese medicaments which negatively charge in solution, such as acetic acid, kojic acid and vitamin C. Such iontophoresis is very effective in treating or removing dermatophytosis and deposited pigments. In this case, superposition of the aforementioned low-frequency voltage, in particular, that having a diphasic action potential waveform, on a square wave voltage without positive voltage component, frequency of about 0.1-10 hertz, preferably, about 0.5-5 hertz, enables a more efficient iontophoresis of the medicaments.
Furthermore, since a low-frequency voltage having a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1 scarcely causes discomfort, pain, inflammation or burns when applied to the skin, it comfortably and efficiently iontophoreses medicaments which positively charge in solution, for example, aminovinyl photosensitizing dyes when such low-frequency voltage, preferably, that having a diphasic action potential waveform, frequency, for example, of about 0.1-10 hertz, preferably, about 0.5-5 hertz, is superposed on a square wave voltage without negative voltage component.
In either case, one can employ an arrangement wherein a square wave having a frequency of about 0.1-10 hertz, preferably, about 0.5-5 hertz, is used as the power source, for example, for a blocking oscillator generating a low-frequency voltage with a diphasic action potential waveform, while another square wave that is different in phase from the former square wave, frequency, for example, of about 0.1-10 hertz, preferably, about 0.5-5 hertz, is applied across electrodes P and E in such manner that the low-frequency voltage and a dc voltage without positive or negative voltage component are successively applied to the electrodes at the period of the square wave; or that a low-frequency voltage having a diphasic action potential waveform with a slightly long pulse interval is superposed on the dc voltage. By either arrangement, a massaging effect of the present device and a pharmaceutically effective component iontophoresed in the deeper part of the skin synergistically cooperate to give an extremely high efficacy.
FIGS. 4 and 5 are illustrative of an electrode which serves as a variable resistor as well, wherein metal plate (3), pressure-sensitive resistor (4), metal plate (3'), insulating member (5) and metal plate (3") are prepared into one body by laminating them in layers between sponge member (2) and curved plastic cover member (1) bearing guide (6) so that the user can handle the electrode. Metal plates (3') and (3") are electrically connected each other, and lead (7) is connected to metal plate (3). Pressure-sensitive resistor (4) has the feature that its electric resistance is relatively high at ambient pressure but decreases as shown in FIG. 6 when pressured.
In use, the user connects the electrode with an output terminal of the circuit shown in FIG. 1 or 3, inserts the hand in guide (6), and places on the skin sponge member (2) which has been soaked in water or an aqueous electrolyte solution. In this case, the magnitude of a treatment voltage across the skin can be finely controlled by increasing or decreasing the pressure to the electrode while allowing sponge member (2) to contact with the skin.
FIG. 7 is illustrative of a variable resistor using a pressure-sensitive resistor, which is advantageously usable as variable resistor VR in the circuit shown in FIG. 1 or 3.
In this variable resistor, metal plate (3) bearing lead (7) is attached to insulating basal plate (8), while pressure-sensitive resistors (4)(4') are attached to metal plate (3) through (9) to leave an appropriate spacing. Insulating cover member (1) is placed over pressure-sensitive resistors (4)(4') through metal plates (3')(3") having lead (7')(7") respectively, while one end of cover member (1) is elastically fixed to basal plate (8) with leaf spring (10).
When out of use, pressure-sensitive resistor (4) located at the side pressured by leaf spring member (10) exhibits a relatively low resistance, while pressure-sensitive resistor (4') located at the side without pressure exhibits a relative high resistance. When in use, the magnitude of a treatment voltage across leads (7)(7') or leads (7)(7") can be adequately controlled by increasing or decreasing the pressure to pressure-sensitive resistor (4') through cover member (1) to change the electric resistance of pressure-sensitive resistors (4)(4') with respect to fulcrum (9).
Leads (7)(7') or leads (7)(7") and an output terminal of a low-frequency oscillator can be conveniently interconnected by using a pair of 2P plug (11) and 2P socket (12) as shown in FIG. 8 wherein the size of plugs is changed in accordance with polarity. In this case, by further changing the distance between the plugs in accordance with the magnitude of the voltage to be applied, the user neither applies a high voltage to the site to be applied with a low voltage nor connects a plug to a socket with wrong polarity.
FIG. 9 is illustrative of an electrode arrangement which serves as an active and a dispersive electrodes. Metal plates (3)(3') bearing leads (7)(7') respectively are tightly placed between the upper and lower sides of insulating basal plate (8) which has been attached with guide (6) so that the user can handle the electrode. It is recommendable to prepare the electrode into a curved shape in order to ensure a better fitness to the affected site, similarly as in the case of the electrode shown in FIG. 4.
In use, the electrode is connected with an output terminal of the circuit shown in FIG. 1 or 3, and sponge members (2)(2') are immersed in water or an electrolyte solution, after which the user inserts the hand in guide (6) and places sponge member (2') on the affected site.
The electrode has the features that it enables an efficient therapy of various sites in human body because the user connects only one electrode to a low-frequency electrotherapeutic device and handles the electrode during therapy.
In the electrode a shown in FIG. 10, metal plate (3") is additionally provided on the upper surface of guide (6) in the electrode shown in FIG. 9, and then electrically connected with lead (7).
The electrode has the feature that it reduces electric shock to the hand in contact with the electrode because, when used, for example, in bath, a major part of current flows through an electric resistance that is formed between metal plate (3") and the human body through water.
An active and a dispersive electrode can be connected into one body by attaching a pair of half circular metal plate bearing a lead to a base plate of an insulating material shaped, for example, into triangle, square or circle while electrically insulating the metal plates, and covering the metal plates with a sponge member in the same shape; or concentrically attaching to the basal plate a ring-shaped metal plate having a lead and a ring- or disc-shaped metal plate bearing a lead to leave an appropriate spacing, and covering the metal plates with a sponge member of the same shape.
An active electrode prepared, for example, into a roller shape can be rotatably attached to one end of a vessel containing a low-frequency electrotherapeutic device, while the peripheral part of the vessel to be handled can be covered with a band-shaped dispersive electrode.
Since the present invention is arranged in this way, an extremely efficacious massotherapy can be achieved with causing less pain.
Furthermore, massotherapy using the present electrotherapeutic device helps to promote the metabolism of the scalp. This is effective in promoting the regeneration and growth of hair, as well as in preventing the loss of hair and keeping its health.
In addition, a much higher efficacy is achievable by conducting the massotherapy in bath.
The electrotherapeutic device of the invention has the feature that it enables a comfortable iontophoresis without fear of causing pain, inflammation or burn.
While the prefaced forms of the present invention have been described, it is to be understood that modifications will be apparent to those skilled in the art without departing from the spirit of the invention.

Claims (4)

I claim:
1. In a low-frequency electrotherapeutic device which comprises an oscillator capable of generating a low-frequency voltage and a pair of electrodes connected to an output terminal of said oscillator, the low-frequency voltage being applied to a human body through said pair of electrodes, the improvement wherein said low-frequency voltage has a ratio of positive voltage component to negative voltage component in the range of about 0.1:1-0.5:1 and in the low-frequency voltage its reverse energy is larger than forward energy thereof.
2. The device of claim 1, wherein said low-frequency voltage is a pulsating voltage having a pulse interval.
3. The device of claim 2, wherein the pulse interval of said pulsating voltage increases and decreases at prescribed time intervals.
4. The device of claim 1, wherein said low-frequency voltage has a diphasic action potential waveform.
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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997014472A1 (en) 1995-10-20 1997-04-24 Nexmed, Inc. Apparatus and method for delivering electrical stimulus to tissue
US5660836A (en) * 1995-05-05 1997-08-26 Knowlton; Edward W. Method and apparatus for controlled contraction of collagen tissue
US5755753A (en) * 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
US5771890A (en) * 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5948011A (en) * 1995-05-05 1999-09-07 Thermage, Inc. Method for controlled contraction of collagen tissue via non-continuous energy delivery
US6162460A (en) * 1998-03-10 2000-12-19 Lee; Yang-Hee Poultice
WO2001078832A1 (en) 2000-04-17 2001-10-25 Nexmed Holdings, Inc. Electrical stimulation apparatus and method
US6350276B1 (en) 1996-01-05 2002-02-26 Thermage, Inc. Tissue remodeling apparatus containing cooling fluid
US6425912B1 (en) 1995-05-05 2002-07-30 Thermage, Inc. Method and apparatus for modifying skin surface and soft tissue structure
US6430446B1 (en) 1995-05-05 2002-08-06 Thermage, Inc. Apparatus for tissue remodeling
US6594527B2 (en) 1998-09-18 2003-07-15 Nexmed Holdings, Inc. Electrical stimulation apparatus and method
US20040002704A1 (en) * 1996-01-05 2004-01-01 Knowlton Edward W. Treatment apparatus with electromagnetic energy delivery device and non-volatile memory
US20060025837A1 (en) * 1996-01-05 2006-02-02 Stern Roger A Handpiece with RF electrode and non-volatile memory
US7020526B1 (en) 2002-05-16 2006-03-28 Ruan Jin Zhao Electronic gastro-intestinal stimulation device
US7022121B2 (en) 1999-03-09 2006-04-04 Thermage, Inc. Handpiece for treatment of tissue
US7115123B2 (en) 1996-01-05 2006-10-03 Thermage, Inc. Handpiece with electrode and non-volatile memory
US7141049B2 (en) 1999-03-09 2006-11-28 Thermage, Inc. Handpiece for treatment of tissue
US7189230B2 (en) 1996-01-05 2007-03-13 Thermage, Inc. Method for treating skin and underlying tissue
US7229436B2 (en) 1996-01-05 2007-06-12 Thermage, Inc. Method and kit for treatment of tissue
US7267675B2 (en) 1996-01-05 2007-09-11 Thermage, Inc. RF device with thermo-electric cooler
US20080004661A1 (en) * 2000-11-29 2008-01-03 Silverstone Leon M Method and apparatus for treatment of viral diseases
US20100106205A1 (en) * 2008-10-28 2010-04-29 Silverstone Leon M Devices for treatment of viral infections
WO2014207750A1 (en) * 2013-06-28 2014-12-31 Yosef Gross International Technologies Ltd. Skin-care system
US9421367B1 (en) 2000-08-24 2016-08-23 Electroregenesis, Inc. Method and apparatus for performing microcurrent electrotherapy

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5047007A (en) * 1989-12-22 1991-09-10 Medtronic, Inc. Method and apparatus for pulsed iontophoretic drug delivery
US5125894A (en) * 1990-03-30 1992-06-30 Alza Corporation Method and apparatus for controlled environment electrotransport
US6004309A (en) * 1990-03-30 1999-12-21 Alza Corporation Method and apparatus for controlled environment electrotransport
US5213568A (en) * 1990-03-30 1993-05-25 Medtronic Inc. Activity controlled electrotransport drug delivery device
US5224927A (en) * 1990-11-01 1993-07-06 Robert Tapper Iontophoretic treatment system
US6575957B1 (en) 1990-11-01 2003-06-10 Robert Tapper Iontophoretic treatment system
US6600950B1 (en) 1990-11-01 2003-07-29 Robert Tapper Iontophoretic treatment system
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US6139537A (en) * 1990-11-01 2000-10-31 Tapper; Robert Iontophoretic treatment system
US6235013B1 (en) 1990-11-01 2001-05-22 Robert Tapper Iontophoretic treatment system
DE4127951C2 (en) * 1991-08-23 1994-06-09 Boehringer Ingelheim Kg Method and device for counter-field-controlled iontophoresis
JP2570823Y2 (en) * 1991-12-06 1998-05-13 久光製薬株式会社 Plaster-shaped low frequency treatment device
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AT404228B (en) * 1995-11-07 1998-09-25 Horda Mt Device for generating electric pulses
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US6477410B1 (en) 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6792306B2 (en) 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
KR20010018270A (en) * 1999-08-18 2001-03-05 최영욱 Ionphoresor
KR100354291B1 (en) * 2000-04-21 2002-09-28 (주)닥터스텍 Ascorbic acid composition for epidermal dosaging
JP4218204B2 (en) 2000-11-14 2009-02-04 ソニー株式会社 Disk drive device

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE364722C (en) * 1921-02-10 1922-12-06 Siemens Schuckertwerke G M B H Multi-part locking screw plug
DE1175372B (en) * 1962-03-20 1964-08-06 Sutetaro Yamashiki Electric stimulation current device
FR2215199A1 (en) * 1973-01-26 1974-08-23 Lobelson Albert
US3983881A (en) * 1975-05-21 1976-10-05 Telectronics Pty. Limited Muscle stimulator
US4164226A (en) * 1976-08-25 1979-08-14 Robert Tapper Iontophoretic burn-protection electrode structure
US4211222A (en) * 1976-08-25 1980-07-08 Robert Tapper Iontophoretic burn-protection method
US4301794A (en) * 1978-10-18 1981-11-24 Robert Tapper Method for iontophoretic treatment
US4340047A (en) * 1978-10-18 1982-07-20 Robert Tapper Iontophoretic treatment apparatus
FR2540729A1 (en) * 1983-02-16 1984-08-17 Nippon Athletic Ind BEDSPREAD WITH A THERAPEUTIC DEVICE
EP0138347A1 (en) * 1983-09-01 1985-04-24 Kabushiki Kaisya Advance An iontophoresis device
EP0154976A1 (en) * 1984-03-12 1985-09-18 BIO-RESEARCH ASSOCIATES, Inc. Electrical muscle stimulator
FR2584932A1 (en) * 1985-07-19 1987-01-23 Hayashibara Ken ELECTROTHERAPY APPARATUS FOR IONOPHORESIS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55126847U (en) * 1979-03-02 1980-09-08
JPS5646756U (en) * 1979-09-14 1981-04-25
JPS574984U (en) * 1980-06-07 1982-01-11
JPS5941747A (en) * 1982-08-31 1984-03-08 三菱重工業株式会社 Refrigerator

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE364722C (en) * 1921-02-10 1922-12-06 Siemens Schuckertwerke G M B H Multi-part locking screw plug
DE1175372B (en) * 1962-03-20 1964-08-06 Sutetaro Yamashiki Electric stimulation current device
FR2215199A1 (en) * 1973-01-26 1974-08-23 Lobelson Albert
US3983881A (en) * 1975-05-21 1976-10-05 Telectronics Pty. Limited Muscle stimulator
US4164226A (en) * 1976-08-25 1979-08-14 Robert Tapper Iontophoretic burn-protection electrode structure
US4211222A (en) * 1976-08-25 1980-07-08 Robert Tapper Iontophoretic burn-protection method
US4301794A (en) * 1978-10-18 1981-11-24 Robert Tapper Method for iontophoretic treatment
US4340047A (en) * 1978-10-18 1982-07-20 Robert Tapper Iontophoretic treatment apparatus
FR2540729A1 (en) * 1983-02-16 1984-08-17 Nippon Athletic Ind BEDSPREAD WITH A THERAPEUTIC DEVICE
EP0138347A1 (en) * 1983-09-01 1985-04-24 Kabushiki Kaisya Advance An iontophoresis device
EP0154976A1 (en) * 1984-03-12 1985-09-18 BIO-RESEARCH ASSOCIATES, Inc. Electrical muscle stimulator
FR2584932A1 (en) * 1985-07-19 1987-01-23 Hayashibara Ken ELECTROTHERAPY APPARATUS FOR IONOPHORESIS

Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5771890A (en) * 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US6687522B2 (en) 1994-06-24 2004-02-03 Cygnus, Inc. Device for sample of substances using alternating polarity
US6023629A (en) * 1994-06-24 2000-02-08 Cygnus, Inc. Method of sampling substances using alternating polarity of iontophoretic current
US5919219A (en) * 1995-05-05 1999-07-06 Thermage, Inc. Method for controlled contraction of collagen tissue using RF energy
US6425912B1 (en) 1995-05-05 2002-07-30 Thermage, Inc. Method and apparatus for modifying skin surface and soft tissue structure
US6461378B1 (en) 1995-05-05 2002-10-08 Thermage, Inc. Apparatus for smoothing contour irregularities of skin surface
US5948011A (en) * 1995-05-05 1999-09-07 Thermage, Inc. Method for controlled contraction of collagen tissue via non-continuous energy delivery
US5755753A (en) * 1995-05-05 1998-05-26 Thermage, Inc. Method for controlled contraction of collagen tissue
US6453202B1 (en) 1995-05-05 2002-09-17 Thermage, Inc. Method and apparatus for controlled contraction of collagen tissue
US6241753B1 (en) 1995-05-05 2001-06-05 Thermage, Inc. Method for scar collagen formation and contraction
US5660836A (en) * 1995-05-05 1997-08-26 Knowlton; Edward W. Method and apparatus for controlled contraction of collagen tissue
US6470216B1 (en) 1995-05-05 2002-10-22 Thermage, Inc. Method for smoothing contour irregularities of skin surface
US6377854B1 (en) 1995-05-05 2002-04-23 Thermage, Inc. Method for controlled contraction of collagen in fibrous septae in subcutaneous fat layers
US6377855B1 (en) 1995-05-05 2002-04-23 Thermage, Inc. Method and apparatus for controlled contraction of collagen tissue
US6381497B1 (en) 1995-05-05 2002-04-30 Thermage, Inc. Method for smoothing contour irregularity of skin surface by controlled contraction of collagen tissue
US6381498B1 (en) 1995-05-05 2002-04-30 Thermage, Inc. Method and apparatus for controlled contraction of collagen tissue
US5871524A (en) * 1995-05-05 1999-02-16 Thermage, Inc. Apparatus for controlled contraction of collagen tissue
US6430446B1 (en) 1995-05-05 2002-08-06 Thermage, Inc. Apparatus for tissue remodeling
US6438424B1 (en) 1995-05-05 2002-08-20 Thermage, Inc. Apparatus for tissue remodeling
WO1997014472A1 (en) 1995-10-20 1997-04-24 Nexmed, Inc. Apparatus and method for delivering electrical stimulus to tissue
US7115123B2 (en) 1996-01-05 2006-10-03 Thermage, Inc. Handpiece with electrode and non-volatile memory
US6350276B1 (en) 1996-01-05 2002-02-26 Thermage, Inc. Tissue remodeling apparatus containing cooling fluid
US20040002704A1 (en) * 1996-01-05 2004-01-01 Knowlton Edward W. Treatment apparatus with electromagnetic energy delivery device and non-volatile memory
US7267675B2 (en) 1996-01-05 2007-09-11 Thermage, Inc. RF device with thermo-electric cooler
US6749624B2 (en) 1996-01-05 2004-06-15 Edward W. Knowlton Fluid delivery apparatus
US20060025837A1 (en) * 1996-01-05 2006-02-02 Stern Roger A Handpiece with RF electrode and non-volatile memory
US7006874B2 (en) 1996-01-05 2006-02-28 Thermage, Inc. Treatment apparatus with electromagnetic energy delivery device and non-volatile memory
US7229436B2 (en) 1996-01-05 2007-06-12 Thermage, Inc. Method and kit for treatment of tissue
US7189230B2 (en) 1996-01-05 2007-03-13 Thermage, Inc. Method for treating skin and underlying tissue
US6162460A (en) * 1998-03-10 2000-12-19 Lee; Yang-Hee Poultice
US6594527B2 (en) 1998-09-18 2003-07-15 Nexmed Holdings, Inc. Electrical stimulation apparatus and method
US7141049B2 (en) 1999-03-09 2006-11-28 Thermage, Inc. Handpiece for treatment of tissue
US7022121B2 (en) 1999-03-09 2006-04-04 Thermage, Inc. Handpiece for treatment of tissue
WO2001078832A1 (en) 2000-04-17 2001-10-25 Nexmed Holdings, Inc. Electrical stimulation apparatus and method
US9421367B1 (en) 2000-08-24 2016-08-23 Electroregenesis, Inc. Method and apparatus for performing microcurrent electrotherapy
US20080004661A1 (en) * 2000-11-29 2008-01-03 Silverstone Leon M Method and apparatus for treatment of viral diseases
US8532758B2 (en) 2000-11-29 2013-09-10 Leon M. Silverstone Method and apparatus for treatment of viral diseases
US7020526B1 (en) 2002-05-16 2006-03-28 Ruan Jin Zhao Electronic gastro-intestinal stimulation device
US20100106205A1 (en) * 2008-10-28 2010-04-29 Silverstone Leon M Devices for treatment of viral infections
US7983747B2 (en) * 2008-10-28 2011-07-19 Silverstone Leon M Non-invasive method and apparatus for the treatment of viral infections
WO2014207750A1 (en) * 2013-06-28 2014-12-31 Yosef Gross International Technologies Ltd. Skin-care system

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BR8804370A (en) 1989-03-21
DE3888064T2 (en) 1994-08-04
JPS6456060A (en) 1989-03-02
ES2052733T3 (en) 1994-07-16
KR890003416A (en) 1989-04-14
DE3888064D1 (en) 1994-04-07
JPH0367421B2 (en) 1991-10-22
EP0309093A1 (en) 1989-03-29
ATE102062T1 (en) 1994-03-15
EP0309093B1 (en) 1994-03-02
KR960012203B1 (en) 1996-09-16
CA1331787C (en) 1994-08-30

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