|Publication number||US5089024 A|
|Application number||US 07/183,202|
|Publication date||18 Feb 1992|
|Filing date||19 Apr 1988|
|Priority date||19 Apr 1988|
|Publication number||07183202, 183202, US 5089024 A, US 5089024A, US-A-5089024, US5089024 A, US5089024A|
|Inventors||Bruce A. Christie, Gary L. Guenthner, J. Warren Blaker|
|Original Assignee||Storz Instrument Company|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (60), Non-Patent Citations (2), Referenced by (144), Classifications (5), Legal Events (6)|
|External Links: USPTO, USPTO Assignment, Espacenet|
The invention relates to intraocular lenses for the human eye and, particularly, to multifocal lenses of this type which can bring images of objects located at different distances into focus on the retina simultaneously.
FIG. 1 illustrates a human eye in cross-section, showing cornea 13, iris 16, and lens 19. The lens 19 can suffer disease, such as a cataract, in which case surgical removal of the lens may be necessary. After removal, the lens can be replaced by an artificial lens 22, shown in FIG. 2, and which is termed an intraocular lens (IOL). The IOL restores much of the visual acuity of the eye, but has the characteristic of focusing upon the retina only those objects, such as object 29, which are within the depth of field 25 of the focusing system, which includes the IOL 22 and the cornea 13. Other objects, such as object 31 located in the far field 27, are not in focus, and thus appear blurred.
A prior art device which appears to mitigate this problem is discussed in U.S. Pat. No. 4,636,211 (Nielsen et al.) The Nielsen patent discusses a bifocal IOL as shown in FIG. 3. The Nielsen patent states that "the one piece body has a centrally located optically powered portion for near vision, designated as number 3, which is surrounded by a far vision optically powered portion 2, the two portions being concentric and coaxial."
The Nielsen patent further states that the difference in focusing power between the near vision region 3 and the far vision region 2 should be about 2.50 diopters.
The Nielsen lens, when used as IOL 22 in FIG. 2, focuses both the near-field object 29 and the far-field object 31 simultaneously upon the retina 28. Because the focus of both images differ by 2.50 diopters, the human visual system is able to reject one of the images and view the image which is preferred.
A disadvantage of the Nielsen approach occurs in the presence of bright light. Nielsen states that the diameter 40 in FIG. 3A of the near vision region 3 should be 2.12 millimeters (mm). This diameter is only slightly larger than the diameter 42 in FIG. 4 of the fully constricted pupil 44 of the average human eye when exposed to bright light. In such a situation, the fully constricted pupil prevents adequate incoming light 46 from reaching the far vision region 2 of Nielsen's lens, causing the image of the far field object 31 in FIG. 2 to become very dim on the retina 28. The fully constricted pupil inhibits clear vision of the far field object 31.
Further, even if the pupil does not fully constrict (i.e., the iris 16 does not fully cover Nielsen's far vision region 2 as assumed in the paragraph above), some visual distortion will probably occur. For example, the unblocked, or exposed, part of region 2 of the IOL will resemble annulus 47 in FIG. 5. The annulus 47 is reduced in height, which is indicated by dimension 49, which causes a reduction in cross-sectional area, which, in turn, reduces the amount of light which the annulus can collect.
This reduction in collected light causes the far field image (focused by the annulus) to be less bright than the near field image (focused by region 3). It is believed that this difference in brightness will cause the far field image to be overpowered by the brightness of the near field image, rendering the far field image useless.
The degradation of the far field image just described occurs at a time when objects in the far field are of greatest interest. That is, the bright light, which is responsible for the contraction of the pupil, is generally experienced during outdoor activities, when people are interested in viewing distant objects. However, as just shown, the pupil constriction can obstruct the far-vision region of the IOL and cause distortion or loss of distance vision.
It is an object of the present invention to provide an improved intraocular lens.
It is a further object of the invention to provide an improved intraocular lens which can provide appropriate vision under a wide range of lighting conditions.
It is a further object of the invention to provide an improved intraocular lens which can focus objects at different distances from the eye in which the lens is implanted.
It is a further object of the invention to provide an improved intraocular lens which has bifocal capability, and, further, the ability to focus far field objects in bright light, when the pupil of the eye is constricted.
In one form of the invention, an intraocular lens contains three concentric regions. An innermost region provides far-field vision. A middle region, surrounding the innermost region, provides near-field vision. An outermost region, surrounding the middle region, provides far-field vision. The innermost region is of a size such that, when the pupil constricts in bright light, the innermost region remains exposed to incoming light, and can thus focus distant images in bright light.
FIG. 1 illustrates a human eye in cross section.
FIG. 2 illustrates an intraocular lens which can replace the natural lens 19 in FIG. 1.
FIGS. 3A and 3B illustrate a type of bi-focal intraocular lens found in the prior art.
FIGS. 4 and 5 illustrate obstruction of region 2 of the prior art lens of FIG. 3 which occurs when the pupil 44 constricts in bright light.
FIG. 6 illustrates one form of the invention.
FIG. 7 illustrates the invention of FIG. 6 when implanted in the eye.
FIG. 8 illustrates several alternate embodiments of the invention.
FIG. 9 illustrates, in exaggerated form, the lens of FIG. 3A in cross-section.
FIG. 10 illustrates a type of lens blank from which the embodiment of FIG. 6 can be manufactured.
FIG. 11 illustrates the cross-section of a lens manufactured from the blank 65 in FIG. 10.
FIG. 12 illustrates three different types of lens which can be used as the lens of FIG. 6.
FIGS. 13A and 13B illustrate different regions of the lens of FIG. 6 which are exposed under different lighting conditions.
FIG. 14 illustrates a lens of the present invention, including haptic members which are used to support and center the lens in the eye.
FIG. 6 illustrates one form of the invention. An intraocular lens 50 contains three regions of focus: 50A, 50B, and 50C. The innermost region 50C has a diameter of 1.00 mm, as indicated. The other two regions, 50B and 50C have respective diameters of 2.36 and 6.00 mm as shown. Two of the regions, namely, regions 50A and 50C, are identical in refractive power at +21.0 diopters, and supply focus for distant vision. The third region 50B is at 24.5 diopters and supplies focus for near vision. (The powers given are measured in aqueous media, not in air, because the lens will be immersed in an aqueous medium in the eye.) All three regions 50A-C are concentric about center point 52A.
When the lens of FIG. 6 is implanted as shown in FIG. 7, imaging of far-field objects is possible despite full constriction of the pupil 44 to the size shown because the central region 50C remains fully exposed. Therefore, distant vision is still available to the patient under bright light conditions. That is, the invention maintains a far field focusing lens (21.0 diopters in the case of region 50C in FIG. 6) within the aperture of the pupil when the iris is fully contracted, that is, when the pupil is at its minimal diameter.
Other configurations in addition to that shown in FIG. 6 can be used. FIGS. 8A-H show ten such configurations. All are 6.00 mm in diameter. A fully constricted pupil is illustrated by dashed circle 55 contained within each figure. Further, as in FIG. 6, zones of different refractive power are labeled, such as 24.5 D, which indicates a refractive power of 24.5 diopters. In addition, dimensions are identified and are explained in the following Table 1, which is considered self-explanatory.
TABLE 1______________________________________Figure Dimension Size______________________________________8A 70 90 degrees8B 73 60 degrees8C 76 1.00 mm8D 79 1.00 mm8D 82 1.00 mm8F 85 2.00 mm8G 88 45 degrees8G 91 90 degrees8H 93 1.50 mm8I 97 1.50 mm______________________________________
A particular type of construction of the lens of FIG. 6 will now be discussed. It is common to construct lenses of the Nielsen type by standard methods of grinding and polishing. One such lens is shown in cross-section in grossly exaggerated form in FIG. 9. Far focus regions 2 have radii of curvature R1 and R2 as indicated. Near focus region 3 has different radii, R3 and R4, as further indicated. The lens is not perfectly smooth, as discontinuities exist at points 61 where the radius changes.
The difference in curvature (i.e., R1, in general, does not equal R3) of near vision region 3 as compared with far vision region 2 is necessary because the entire lens is constructed of a single material, such as a polymethyl methacrylate (PMMA), having a single index of refraction.
In an alternate form construction, the lens can be made of more than one material. As shown in FIG. 10, three concentric cylinders 60A-C are co-extruded from a die 63 as known in the art. Cylinders 60A and 60C can be constructed of PMMA or a similar biocompatible material, having a refractive index of 1.491. Cylinder 60B can be constructed of a different material, such as polyallyl methacrylate, having a refractive index of 1.514, or a similar biocompatible material.
A lens blank 65 in the form of a disc is sliced from the extruded cylinders, and ground and polished to the desired shape as shown in cross-section in FIG. 11. This lens, in contrast to the lens of FIG. 9, has only two radii of curvature, namely radii R7 and R8, which can, in some cases, be identical. (If they are identical, then only one radius is said to exist. Further, if one radius is infinite, as in a plano-convex lens, the surface having the infinite radius is flat.) It is the differing indices of refraction of the material in region 60B as compared with that in regions 60A and 60C which provides the different focusing powers in the regions. That is, like the lens of FIG. 6, in the lens of FIG. 10, regions 60A, 60B, and 60C have powers of +21.0, +24.5, and +21.0 diopters, respectively.
Several important features of the invention are the following.
1. The cross-section of the lens can, alternately, be plano-convex as shown in FIG. 12A; bi-convex, as shown in FIG. 12B; or concave-convex (i.e., of the meniscus type), as shown in FIG. 12C. Further, the lens may be manufactured aspherically, in order to correct for spherical or other aberrations.
2. Two different regions of focus (e.g., regions 50C and 50B in FIG. 6, which differ in power by 3.50 diopters) have been considered in the discussion above. However, a greater number of focal regions can be used. For example, in FIG. 6, three, not two, refractive powers can be used: (a) region 50C may be used for far field focus, using a correction of 21.0 diopters, (b) region 50B may be used for a mid field correction of 22.25 diopters, while (c) region 50A may be used for near-field focus, using a correction of 24.5 diopters.
3. In some situations, it can be desirable to construct the lens such that a far field image under bright light conditions is projected onto the retina with the same brightness as a near field image under low light conditions. For example, a given intensity of illumination, I1, of 100 lux, is assumed under the bright light condition, and a second, lower intensity, I2, of 6 lux, is assumed for the low light condition.
It is further assumed that the pupil has a size illustrated by dashed circle 55A in FIG. 13A under the bright light condition and a diameter of dashed circle 55B in FIG. 13B under the low light condition. It is also assumed that region 50C is the region of far field focus, while region 50A is the region of near field focus. In addition, the area of region 50C in FIG. 13A is designated as A1, while the area of region 50B in FIG. 13B is designated as A2.
In this embodiment, the lens is designed such that (I1)×(A1)=(I2)×(A2), meaning that bright light intensity (I1) times far focus area (A1) equals low light intensity (I2) times near focus area (A2). This arrangement will provide equal brightness of the near and far field images under bright and low light conditions, because the light intensities per unit area have been equalized for A1 and A2.
4. In the optical art, refractive power, measured in diopters, is generally defined as n/L, wherein n is the refractive index of the medium surrounding a lens and L is the focal length of the lens in air. Thus, one can see that the far-field focusing region 50C in FIG. 6, at 21.0 diopters, has a longer focal length than the near-field region 50B, at 24.5 diopters.
5. FIGS. 8A and 8B show lens regions which are geometric sectors of the circle defined by the periphery 90 of the lens. FIG. 8C shows regions which are parallel bands or stripes. FIG. 8D shows regions occupying the cells in a rectangular gridwork, or chessboard. FIGS. 8E and 8F show regions which are circular, but having centers displaced from the center 52A of the periphery 90. That is, the lens regions are not concentric. Further, FIG. 8E shows a lens which is symmetric about line 92.
FIG. 8G shows regions which are sectors, but not identical. For example, angle 91, subtended by one sector, is about 90 degrees; angles 88 are about 45 degrees; and the lower sector 94 subtends an angle of about 180 degrees. FIGS. 8H and 8I both show a lower sector subtending an angle of 180 degrees. However, in FIG. 8H, the upper section contains two concentric semicircles, while in FIG. 8I the upper section contains crescent-shaped regions. In FIG. 8J, the regions are crescent-shaped and symmetric about line 92. Central region 96 is in the shape of the common area of intersection of two circles, one having circumference 98, and the other having circumference 100. The shape of central region 96 can be called "cat's pupil," because of the resemblance of the shape to the pupil of that animal.
The individual regions shown in FIG. 8 may be spherical lenses or aspheric lenses corrected for aberrations, as discussed above.
In all lenses of FIGS. 8A through 8J, the constricted pupil 55 admits light through a far-field focusing region, such as the hatched region in FIG. 8D having a power of 21.0 D. Similarly, the pupil in FIG. 7 which is constricted to a diameter 44, admits light through far-field focusing region 50C.
6. If the lens should become de-centered upon the eye, the light distribution upon the retina remains substantially unaffected, so long as the amount of de-centering is not too large.
7. It was stated above that the innermost region 50C in FIG. 6 has a diameter of 1.00 mm, the middle region 50B has a diameter of 2.36 mm, and the outer region 50A has a diameter of 6.00 mm. These dimensions fall within the ranges of 0.75-1.50, 2.00-3.00, and 5.00-10.00 mm for the innermost, middle, and outer regions, respectively, and diameters falling within these ranges can be used in the invention.
8. While the IOL of FIGS. 2 and 7 has been shown as positioned in the posterior chamber of the eye, the lens body of the present invention can be implanted in either the posterior or the anterior chamber with techniques commonly known and used in the field today.
Further, although the invention is illustrated in the drawings as being implanted without accompanying haptic members, the lens body, when in use in the eye, is typically combined with a pair, or a greater number, of haptic members for positioning and centering of the lens in the eye. The haptic members can be of any of the sizes and shapes commonly known and used today, such as the Shearing J-loops, the Simcoe C-loops, the Sinsky modified J-loops, etc. For illustrative purposes, an intraocular lens utilizing a lens body 50 of the present invention with a pair of generally J-type loop haptic members 105 is shown in FIG. 14. The haptic members 105 can be affixed to the lens body in any of the methods in common use today, or the lens and haptics can be formed as an integral, one-piece structure.
Numerous substitutions and modifications can be undertaken without departing from the true spirit and scope of the invention as defined in the following claims.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1518405 *||19 May 1923||9 Dec 1924||American Optical Corp||Ophthalmic lens|
|US2878721 *||3 Feb 1954||24 Mar 1959||Farrand Optical Co Inc||Multifocal ophthalmic lenses|
|US3034403 *||3 Apr 1959||15 May 1962||Neefe Hamilton Res Company||Contact lens of apparent variable light absorption|
|US3270099 *||7 Dec 1964||30 Aug 1966||Richard N Camp||A method for making multi-focal length contact lenses|
|US3339997 *||30 Jul 1962||5 Sep 1967||Plastic Contact Lens Company||Bifocal ophthalmic lens having different color distance and near vision zones|
|US3458870 *||25 May 1964||5 Aug 1969||William Stone Jr||Artificial corneal implants having a removable lens member|
|US3555126 *||19 Dec 1967||12 Jan 1971||Abraham Gitson||Method of making a mold and molding a bifocal lens|
|US3614217 *||9 Jul 1969||19 Oct 1971||Leonard Bronstein||Fused concentric trifocal corneal contact lens|
|US3711870 *||7 Dec 1971||23 Jan 1973||R Deitrick||Artificial lens implant|
|US3726587 *||9 Mar 1971||10 Apr 1973||C Kendall||Bifocal corneal contact lens and method of making same|
|US3794414 *||12 May 1972||26 Feb 1974||Jessen Inc Wesley||Multiple focal contact lens|
|US3913148 *||26 Dec 1974||21 Oct 1975||Potthast Ernst W||Intraocular lens apparatus|
|US3950082 *||15 Jan 1975||13 Apr 1976||David Volk||Ophthalmic lens for presbyopia and aphakia|
|US4010496 *||1 Oct 1975||8 Mar 1977||Neefe Charles W||Bifocal lens which positions within the anterior chamber|
|US4118853 *||19 Oct 1976||10 Oct 1978||Essilor International, Cie Generale D'optique||Method of making an ophthalmic lens of progressively variable focal power|
|US4172297 *||16 Mar 1978||30 Oct 1979||Inprohold Establishment||Artificial implant lens|
|US4174156 *||31 Oct 1977||13 Nov 1979||Gilbert Glorieux||Optical lens for differential correction|
|US4206518 *||31 Jan 1977||10 Jun 1980||Fritz Jardon||Intraocular lens device|
|US4253199 *||25 Sep 1978||3 Mar 1981||Surgical Design Corporation||Surgical method and apparatus for implants for the eye|
|US4254509 *||9 Apr 1979||10 Mar 1981||Tennant Jerald L||Accommodating intraocular implant|
|US4315673 *||5 May 1980||16 Feb 1982||Optische Werke G. Rodenstock||Progressive power ophthalmic lens|
|US4316293 *||6 Mar 1981||23 Feb 1982||Bayers Jon Herbert||Flexible intraocular lens|
|US4338005 *||21 Apr 1980||6 Jul 1982||Cohen Allen L||Multifocal phase place|
|US4365360 *||11 Dec 1981||28 Dec 1982||Ong Tiong S||Lens designed for implantation into a lens capsule of a human eye|
|US4377329 *||26 Feb 1980||22 Mar 1983||Stanley Poler||Contact lens or the like|
|US4402579 *||29 Jul 1981||6 Sep 1983||Lynell Medical Technology Inc.||Contact-lens construction|
|US4412359 *||26 Apr 1982||1 Nov 1983||Myers William D||Posterior chamber lens implant|
|US4418431 *||17 Dec 1981||6 Dec 1983||Feaster Fred T||Intraocular lens|
|US4418991 *||9 Jun 1980||6 Dec 1983||Breger Joseph L||Presbyopic contact lens|
|US4435856 *||14 Apr 1982||13 Mar 1984||Esperance Francis A L||Bifocal intraocular lens structure and spectacle actuation frame|
|US4466705 *||30 Sep 1982||21 Aug 1984||Michelson Paul E||Fluid lens|
|US4477158 *||15 Oct 1981||16 Oct 1984||Pollock Stephen C||Lens system for variable refraction|
|US4504982 *||5 Aug 1982||19 Mar 1985||Optical Radiation Corporation||Aspheric intraocular lens|
|US4512040 *||9 Jun 1982||23 Apr 1985||Mcclure Hubert L||Bifocal intraocular lens|
|US4514061 *||20 Oct 1983||30 Apr 1985||American Optical Corporation||Progressive power ophthalmic lenses|
|US4525043 *||21 Apr 1980||25 Jun 1985||Leonard Bronstein||Contact lens|
|US4564484 *||26 Nov 1984||14 Jan 1986||Neefe Charles W||Production of soft lenses having reduced spherical aberrations|
|US4573998 *||5 Feb 1982||4 Mar 1986||Staar Surgical Co.||Methods for implantation of deformable intraocular lenses|
|US4575373 *||2 Nov 1984||11 Mar 1986||Johnson Don R||Laser adjustable intraocular lens and method of altering lens power|
|US4580882 *||21 Apr 1983||8 Apr 1986||Benjamin Nuchman||Continuously variable contact lens|
|US4593981 *||6 May 1983||10 Jun 1986||Master Contact Lens Labs Inc.||Bifocal contact lens|
|US4605409 *||21 May 1984||12 Aug 1986||Kelman Charles D||Intraocular lens with miniature optic having expandable and contractible glare-reducing means|
|US4619657 *||23 Dec 1985||28 Oct 1986||Keates Richard H||Flexible intraocular lens holder|
|US4636211 *||13 Mar 1984||13 Jan 1987||Nielsen J Mchenry||Bifocal intra-ocular lens|
|US4637697 *||19 Oct 1983||20 Jan 1987||Pilkington P.E. Limited||Multifocal contact lenses utilizing diffraction and refraction|
|US4640593 *||20 Sep 1983||3 Feb 1987||Seiko Epson Kabushiki Kaisha||Progressive multifocal ophthalmic lenses|
|US4642112 *||14 Apr 1982||10 Feb 1987||Pilkington P.E. Limited||Artificial eye lenses|
|US4655565 *||13 Feb 1985||7 Apr 1987||Pilkington P.E. Limited||Ophthalmic lenses with diffractive power|
|US4702573 *||25 Aug 1986||27 Oct 1987||Morstad David P||Variable powered contact lens|
|US4710193 *||18 Aug 1986||1 Dec 1987||David Volk||Accommodating intraocular lens and lens series and method of lens selection|
|US4710197 *||30 Oct 1981||1 Dec 1987||Anthony Donn||Intraocular-external lens combination system and method of using same|
|US4720286 *||20 Jul 1984||19 Jan 1988||Bailey Kelvin E||Multifocus intraocular lens|
|US4752123 *||19 Nov 1985||21 Jun 1988||University Optical Products Co.||Concentric bifocal contact lens with two distance power regions|
|US4795462 *||24 Aug 1987||3 Jan 1989||Grendahl Dennis T||Cylindrically segmented zone of focus artificial lens|
|US4813955 *||7 Sep 1984||21 Mar 1989||Manfred Achatz||Multifocal, especially bifocal, intraocular, artificial ophthalmic lens|
|US4898461 *||14 Jun 1989||6 Feb 1990||Valdemar Portney||Multifocal ophthalmic lens|
|DE3332313A1 *||7 Sep 1983||4 Apr 1985||Titmus Eurocon Kontaktlinsen||Multifokale, insbesondere bifokale intraokulare kuenstliche augenlinse|
|FR1103399A *||Title not available|
|GB939016A *||Title not available|
|WO1986003961A1 *||30 Dec 1985||17 Jul 1986||Antti Vannas||Intraocular lens|
|1||J. Warren Blaker, "Modern Lens Design for Today & Tomorrow", break-out session: Amer. Society of Cataract & Refractive Surgery--Seminar, Apr. 9, 1986.|
|2||*||J. Warren Blaker, Modern Lens Design for Today & Tomorrow , break out session: Amer. Society of Cataract & Refractive Surgery Seminar, Apr. 9, 1986.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US5192317 *||8 Apr 1992||9 Mar 1993||Irvin Kalb||Multi focal intra-ocular lens|
|US5192318 *||11 Aug 1992||9 Mar 1993||Schneider Richard T||One-piece bifocal intraocular lens construction|
|US5217489 *||3 Mar 1992||8 Jun 1993||Alcon Surgical, Inc.||Bifocal intraocular lens|
|US5344448 *||9 Mar 1993||6 Sep 1994||Schneider Richard T||Multi-focal intra-ocular implant|
|US5349396 *||25 Oct 1993||20 Sep 1994||Johnson & Johnson Vision Products, Inc.||Clear axis, segmented multifocal ophthalmic lens|
|US5366500 *||6 Nov 1992||22 Nov 1994||Richard T. Schneider||One-piece bifocal intraocular lens construction|
|US5443507 *||5 Apr 1993||22 Aug 1995||Adatomed Pharmazeutische Und Medizintechnische Gesellschaft Mbh||Intraocular lens set|
|US5619289 *||16 Sep 1994||8 Apr 1997||Permeable Technologies, Inc.||Multifocal contact lens|
|US5662706 *||14 Jun 1996||2 Sep 1997||Pbh, Inc.||Variable transmissivity annular mask lens for the treatment of optical aberrations|
|US5691797 *||19 Jan 1996||25 Nov 1997||Permeable Technologies, Inc.||Multifocal contact lens|
|US5702440 *||26 Jan 1996||30 Dec 1997||Allergan||Multifocal ophthalmic lens for dim-lighting conditions|
|US5757458 *||30 Sep 1996||26 May 1998||Pilkington Barnes Hind, Inc.||Annular mask contact lenses|
|US5786883 *||13 Sep 1993||28 Jul 1998||Pilkington Barnes Hind, Inc.||Annular mask contact lenses|
|US5805260 *||12 Sep 1996||8 Sep 1998||Johnson & Johnson Vision Products, Inc.||Combined multifocal toric lens designs|
|US5812235 *||4 Sep 1996||22 Sep 1998||Pemrable Technologies Inc.||Multifocal corneal contact lenses|
|US5812236 *||15 Nov 1996||22 Sep 1998||Permeable Technologies, Inc.||Multifocal corneal contact lens pair|
|US5898473 *||25 Apr 1997||27 Apr 1999||Permeable Technologies, Inc.||Multifocal corneal contact lens|
|US5905561 *||14 Jun 1996||18 May 1999||Pbh, Inc.||Annular mask lens having diffraction reducing edges|
|US5919229 *||30 Jun 1997||6 Jul 1999||Allergan||Multifocal opthalmic lens|
|US5965330 *||6 Dec 1996||12 Oct 1999||Pbh, Inc.||Methods for fabricating annular mask lens having diffraction-reducing edges|
|US6051025 *||13 Mar 1997||18 Apr 2000||Corneal Laboratoires||Flexible intraocular implant and set of such implants|
|US6090141 *||13 Aug 1997||18 Jul 2000||Lindstrom; Richard L.||Small intracorneal lens|
|US6158862 *||4 Dec 1997||12 Dec 2000||Alcon Laboratories, Inc.||Method of reducing glare associated with multifocal ophthalmic lenses|
|US6221105||28 Dec 1998||24 Apr 2001||Allergan||Multifocal ophthalmic lens|
|US6231603||10 Nov 1998||15 May 2001||Allergan Sales, Inc.||Accommodating multifocal intraocular lens|
|US6406494||22 Mar 2000||18 Jun 2002||Allergan Sales, Inc.||Moveable intraocular lens|
|US6503276||30 Mar 2001||7 Jan 2003||Advanced Medical Optics||Accommodating multifocal intraocular lens|
|US6537317||3 May 2000||25 Mar 2003||Advanced Medical Optics, Inc.||Binocular lens systems|
|US6547822||3 May 2000||15 Apr 2003||Advanced Medical Optics, Inc.||Opthalmic lens systems|
|US6551354||9 Mar 2000||22 Apr 2003||Advanced Medical Optics, Inc.||Accommodating intraocular lens|
|US6554859||3 May 2000||29 Apr 2003||Advanced Medical Optics, Inc.||Accommodating, reduced ADD power multifocal intraocular lenses|
|US6576011||26 Feb 2001||10 Jun 2003||Advanced Medical Optics, Inc.||Multifocal ophthalmic lens|
|US6576012||28 Mar 2001||10 Jun 2003||Advanced Medical Optics, Inc.||Binocular lens systems|
|US6599317||7 Sep 2000||29 Jul 2003||Advanced Medical Optics, Inc.||Intraocular lens with a translational zone|
|US6616692||3 Sep 1999||9 Sep 2003||Advanced Medical Optics, Inc.||Intraocular lens combinations|
|US6638305||15 May 2001||28 Oct 2003||Advanced Medical Optics, Inc.||Monofocal intraocular lens convertible to multifocal intraocular lens|
|US6645246||7 Sep 2000||11 Nov 2003||Advanced Medical Optics, Inc.||Intraocular lens with surrounded lens zone|
|US6660035||2 Aug 2000||9 Dec 2003||Advanced Medical Optics, Inc.||Accommodating intraocular lens with suspension structure|
|US6790232||30 Apr 1999||14 Sep 2004||Advanced Medical Optics, Inc.||Multifocal phakic intraocular lens|
|US6824563||18 Feb 2003||30 Nov 2004||Advanced Medical Optics, Inc.||Binocular lens systems|
|US6972033||26 Aug 2002||6 Dec 2005||Advanced Medical Optics, Inc.||Accommodating intraocular lens assembly with multi-functional capsular bag ring|
|US7063422||12 Apr 2004||20 Jun 2006||Novartis Ag||Multifocal ophthalmic lens|
|US7377640||23 Jun 2006||27 May 2008||Amo Groningen, B.V.||Multifocal ophthalmic lens|
|US7377641||23 Jun 2006||27 May 2008||Amo Groningen B.V.||Multifocal ophthalmic lens|
|US7404637||3 May 2006||29 Jul 2008||Boston Innovative Optics, Inc.||System and method for increasing the depth of focus of the human eye|
|US7404638||22 Nov 2005||29 Jul 2008||Boston Innovative Optics, Inc.||System and method for increasing the depth of focus of the human eye|
|US7455404||25 Oct 2005||25 Nov 2008||Advanced Medical Optics, Inc.||Ophthalmic lens with multiple phase plates|
|US7491350||1 Dec 2004||17 Feb 2009||Acufocus, Inc.||Method of making an ocular implant|
|US7497572||16 Jul 2007||3 Mar 2009||Novartis Ag||Toric contact lenses with controlled optical power profile|
|US7628810||26 May 2004||8 Dec 2009||Acufocus, Inc.||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US7670371||11 Apr 2007||2 Mar 2010||Amo Groningen Bv||Multifocal ophthalmic lens|
|US7713299||29 Dec 2006||11 May 2010||Abbott Medical Optics Inc.||Haptic for accommodating intraocular lens|
|US7763069||28 Dec 2005||27 Jul 2010||Abbott Medical Optics Inc.||Accommodating intraocular lens with outer support structure|
|US7780729||5 Oct 2004||24 Aug 2010||Visiogen, Inc.||Intraocular lens|
|US7871437||21 Dec 2007||18 Jan 2011||Amo Groningen B.V.||Accommodating intraocular lenses and associated systems, frames, and methods|
|US7896916||1 Dec 2003||1 Mar 2011||Amo Groningen B.V.||Multifocal ophthalmic lens|
|US7905917||12 Oct 2005||15 Mar 2011||Bausch & Lomb Incorporated||Aspheric lenses and lens family|
|US7922326||25 Nov 2008||12 Apr 2011||Abbott Medical Optics Inc.||Ophthalmic lens with multiple phase plates|
|US7976577||14 Apr 2005||12 Jul 2011||Acufocus, Inc.||Corneal optic formed of degradation resistant polymer|
|US7984990||24 Sep 2009||26 Jul 2011||Abbot Medical Optics Inc.||Ophthalmic lens with multiple phase plates|
|US8025823||19 Apr 2006||27 Sep 2011||Visiogen, Inc.||Single-piece accommodating intraocular lens system|
|US8034108||28 Mar 2008||11 Oct 2011||Abbott Medical Optics Inc.||Intraocular lens having a haptic that includes a cap|
|US8048156||28 Dec 2007||1 Nov 2011||Abbott Medical Optics Inc.||Multifocal accommodating intraocular lens|
|US8052752||5 Aug 2003||8 Nov 2011||Abbott Medical Optics Inc.||Capsular intraocular lens implant having a refractive liquid therein|
|US8062361||1 Aug 2005||22 Nov 2011||Visiogen, Inc.||Accommodating intraocular lens system with aberration-enhanced performance|
|US8079706||3 May 2006||20 Dec 2011||Acufocus, Inc.||Method and apparatus for aligning a mask with the visual axis of an eye|
|US8153156||3 Sep 2004||10 Apr 2012||The United States Of America As Represented By The Department Of Veteran Affairs||Hydrogel nanocompsites for ophthalmic applications|
|US8157374||25 Feb 2010||17 Apr 2012||Abbott Medical Optics Inc.||Ophthalmic lens with multiple phase plates|
|US8182531||14 Jan 2011||22 May 2012||Amo Groningen B.V.||Accommodating intraocular lenses and associated systems, frames, and methods|
|US8187325||19 Apr 2006||29 May 2012||Visiogen, Inc.||Materials for use in accommodating intraocular lens system|
|US8192485||13 Nov 2003||5 Jun 2012||The United States of America, as represented by the Department of Veterens Affairs||Reversible hydrogel systems and methods therefor|
|US8246679||23 Aug 2010||21 Aug 2012||Visiogen, Inc.||Intraocular lens|
|US8287592||3 Jun 2011||16 Oct 2012||Acufocus, Inc.||Ophthalmic devices having a degradation resistant polymer|
|US8343215||1 Jan 2013||Acufocus, Inc.||System and method for increasing the depth of focus of the human eye|
|US8343216||1 Jan 2013||Abbott Medical Optics Inc.||Accommodating intraocular lens with outer support structure|
|US8425597||12 Nov 2009||23 Apr 2013||Abbott Medical Optics Inc.||Accommodating intraocular lenses|
|US8460374||30 Nov 2005||11 Jun 2013||Acufocus, Inc.||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US8465544||23 Sep 2011||18 Jun 2013||Abbott Medical Optics Inc.||Accommodating intraocular lens|
|US8496701||18 May 2012||30 Jul 2013||Amo Groningen B.V.||Accommodating intraocular lenses and associated systems, frames, and methods|
|US8506075||16 Apr 2012||13 Aug 2013||Abbott Medical Optics Inc.||Ophthalmic lens with multiple phase plates|
|US8529623||28 Jan 2011||10 Sep 2013||Amo Groningen B.V.||Multifocal ophthalmic lens|
|US8535376||28 Oct 2010||17 Sep 2013||Bausch & Lomb Incorporated||Aspheric lenses and lens family|
|US8545556||23 Sep 2011||1 Oct 2013||Abbott Medical Optics Inc.||Capsular intraocular lens implant|
|US8585758||4 Feb 2010||19 Nov 2013||Abbott Medical Optics Inc.||Accommodating intraocular lenses|
|US8752958||3 Dec 2012||17 Jun 2014||Boston Innovative Optics, Inc.||System and method for increasing the depth of focus of the human eye|
|US8771348 *||20 Oct 2008||8 Jul 2014||Abbott Medical Optics Inc.||Multifocal intraocular lens|
|US8814934||23 Sep 2011||26 Aug 2014||Abbott Medical Optics Inc.||Multifocal accommodating intraocular lens|
|US8858624||3 May 2006||14 Oct 2014||Acufocus, Inc.||Method for increasing the depth of focus of a patient|
|US8864824||3 May 2006||21 Oct 2014||Acufocus, Inc.||Method and apparatus for aligning a mask with the visual axis of an eye|
|US8894203||27 Feb 2012||25 Nov 2014||Arthur Bradley||Multifocal correction providing improved quality of vision|
|US8906089||30 Aug 2013||9 Dec 2014||Amo Groningen B.V.||Multifocal ophthalmic lens|
|US9005281||10 Dec 2012||14 Apr 2015||Acufocus, Inc.||Masked intraocular implants and lenses|
|US9005283||17 Aug 2012||14 Apr 2015||Visiogen Inc.||Intraocular lens|
|US9011532||15 Jul 2013||21 Apr 2015||Abbott Medical Optics Inc.||Accommodating intraocular lenses|
|US9039760||2 Oct 2012||26 May 2015||Abbott Medical Optics Inc.||Pre-stressed haptic for accommodating intraocular lens|
|US9084674||2 May 2012||21 Jul 2015||Abbott Medical Optics Inc.||Intraocular lens with shape changing capability to provide enhanced accomodation and visual acuity|
|US9138142||3 May 2006||22 Sep 2015||Acufocus, Inc.||Masked intraocular devices|
|US20040082993 *||25 Oct 2002||29 Apr 2004||Randall Woods||Capsular intraocular lens implant having a refractive liquid therein|
|US20040156014 *||1 Dec 2003||12 Aug 2004||Piers Patricia Ann||Multifocal ophthalmic lens|
|US20040207807 *||12 Apr 2004||21 Oct 2004||Lindacher Joseph Michael||Multifocal ophthalmic lens|
|US20050033420 *||26 May 2004||10 Feb 2005||Bruce A. Christie||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20050043794 *||31 Mar 2003||24 Feb 2005||Edward Geraghty||Aspheric intraocular lens|
|US20050046794 *||26 May 2004||3 Mar 2005||Silvestrini Thomas A.||Method and apparatus for aligning a mask with the visual axis of an eye|
|US20060030938 *||12 Oct 2005||9 Feb 2006||Altmann Griffith E||Aspheric lenses and lens family|
|US20060079959 *||30 Nov 2005||13 Apr 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060079960 *||30 Nov 2005||13 Apr 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060098162 *||25 Oct 2005||11 May 2006||Bandhauer Mark H||Ophthalmic lens with multiple phase plates|
|US20060111776 *||9 Jan 2006||25 May 2006||Glick Robert E||Intraocular lens combinations|
|US20060113054 *||14 Apr 2005||1 Jun 2006||Silvestrini Thomas A||Method of making an ocular implant|
|US20060118263 *||1 Dec 2004||8 Jun 2006||Silvestrini Thomas A||Method of making an ocular implant|
|US20060184243 *||24 Oct 2005||17 Aug 2006||Omer Yilmaz||System and method for aligning an optic with an axis of an eye|
|US20060203192 *||22 Nov 2005||14 Sep 2006||David Miller||System and method for increasing the depth of focus of the human eye|
|US20060235428 *||14 Apr 2005||19 Oct 2006||Silvestrini Thomas A||Ocular inlay with locator|
|US20060235514 *||14 Apr 2005||19 Oct 2006||Silvestrini Thomas A||Corneal optic formed of degradation resistant polymer|
|US20060244905 *||23 Jun 2006||2 Nov 2006||Advanced Medical Optics, Inc.||Multifocal ophthalmic lens|
|US20060244906 *||23 Jun 2006||2 Nov 2006||Advanced Medical Optics, Inc.||Multifocal ophthalmic lens|
|US20060253196 *||7 Jul 2006||9 Nov 2006||Advanced Medical Optics, Inc.||Intraocular lens implant having posterior bendable optic|
|US20060259139 *||19 Apr 2006||16 Nov 2006||Gholam-Reza Zadno-Azizi||Accommodating intraocular lens system|
|US20060265058 *||13 Apr 2006||23 Nov 2006||Silvestrini Thomas A||Corneal mask formed of degradation resistant polymer and providing reduced corneal deposits|
|US20060268227 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060268228 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060271176 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060271177 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060271178 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060271179 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060271180 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060271181 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060271182 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060271183 *||3 May 2006||30 Nov 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060271184 *||3 May 2006||30 Nov 2006||Silvestrini Thomas A||Method of making an ocular implant|
|US20060271185 *||3 May 2006||30 Nov 2006||Silvestrini Thomas A||Method of making an ocular implant|
|US20060271187 *||19 Apr 2006||30 Nov 2006||Gholam-Reza Zadno-Azizi||Materials for use in accommodating intraocular lens system|
|US20060274265 *||3 May 2006||7 Dec 2006||Christie Bruce A||Mask configured to maintain nutrient transport without producing visible diffraction patterns|
|US20060274267 *||3 May 2006||7 Dec 2006||David Miller||System and method for increasing the depth of focus of the human eye|
|US20070050025 *||19 Apr 2006||1 Mar 2007||Nguyen Tuan A||Hydraulic configuration for intraocular lens system|
|US20110029073 *||31 Mar 2009||3 Feb 2011||Junzhong Liang||Methods and Devices for Refractive Corrections of Presbyopia|
|USD656526||10 Nov 2009||27 Mar 2012||Acufocus, Inc.||Ocular mask|
|USD681086||15 Feb 2012||30 Apr 2013||Acufocus, Inc.||Ocular mask|
|EP0563783A1 *||24 Mar 1993||6 Oct 1993||Chiron Adatomed Pharmazeutische und Medizintechnische Gesellschaft mbH||Intraocular lens set|
|EP1424049A1||27 Nov 2003||2 Jun 2004||Pharmacia Groningen B.V.||Multifocal ophthalmic lens|
|WO1997026580A1 *||19 Jan 1996||24 Jul 1997||Permeable Tech Inc||Multifocal contact lens|
|WO1997026843A1 *||22 Jan 1997||31 Jul 1997||Allergan Inc||Multifocal ophthalmic lens|
|WO2011028659A1||30 Aug 2010||10 Mar 2011||Arthur Bradley||Multifocal correction providing improved quality of vision|
|WO2013166308A1 *||2 May 2013||7 Nov 2013||Abbott Medical Optics Inc.||Intraocular lens with shape changing capabiltiy to provide enhanced accomodation and visual acuity|
|U.S. Classification||623/6.28, 351/159.05|
|17 Aug 1988||AS||Assignment|
Owner name: STORZ INSTRUMENT COMPANY, 3365 TREE COURT INDUSTRI
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:CHRISTIE, BRUCE A.;GUENTHNER, GARY L.;BLAKER, J. W.;REEL/FRAME:004929/0737
Effective date: 19880809
Owner name: STORZ INSTRUMENT COMPANY, (MISSOURI CORPORATION),
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:CHRISTIE, BRUCE A.;GUENTHNER, GARY L.;BLAKER, J. W.;REEL/FRAME:004929/0737
Effective date: 19880809
|26 Jul 1995||FPAY||Fee payment|
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|9 Aug 1999||FPAY||Fee payment|
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|28 Jul 2003||FPAY||Fee payment|
Year of fee payment: 12
|26 Mar 2008||AS||Assignment|
Owner name: CREDIT SUISSE, NEW YORK
Free format text: SECURITY AGREEMENT;ASSIGNORS:BAUSCH & LOMB INCORPORATED;WP PRISM INC.;B&L CRL INC.;AND OTHERS;REEL/FRAME:020733/0765
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Owner name: CREDIT SUISSE,NEW YORK
Free format text: SECURITY AGREEMENT;ASSIGNORS:BAUSCH & LOMB INCORPORATED;WP PRISM INC.;B&L CRL INC.;AND OTHERS;REEL/FRAME:020733/0765
Effective date: 20080320
|5 Aug 2012||AS||Assignment|
Owner name: BAUSCH & LOMB INCORPORATED, NEW YORK
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