US4917951A - Lipid vesicles formed of surfactants and steroids - Google Patents
Lipid vesicles formed of surfactants and steroids Download PDFInfo
- Publication number
- US4917951A US4917951A US07/124,824 US12482487A US4917951A US 4917951 A US4917951 A US 4917951A US 12482487 A US12482487 A US 12482487A US 4917951 A US4917951 A US 4917951A
- Authority
- US
- United States
- Prior art keywords
- polyoxyethylene
- lipid
- vesicles
- ranges
- lipid vesicles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0008—Detergent materials or soaps characterised by their shape or physical properties aqueous liquid non soap compositions
- C11D17/0026—Structured liquid compositions, e.g. liquid crystalline phases or network containing non-Newtonian phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1277—Processes for preparing; Proliposomes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/829—Liposomes, e.g. encapsulation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
- Y10T428/2984—Microcapsule with fluid core [includes liposome]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Dispersion Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
Description
TABLE 1 ______________________________________ Test Number 1. 2. 3. 4. 5. 6. ______________________________________ B56 (ML) 0.5 0.5 0.5 0.5 0.5 0.5 CHOL (MG) 0.0 26 52 78 92 130 WATER (ML) 2.0 2.0 2.0 2.0 2.0 2.0 ______________________________________
TABLE 2 ______________________________________ Test Number 1. 2. 3. 4. 5. 6. ______________________________________ B93 (ML) 0.5 0.5 0.5 0.5 0.5 0.5 CHOL (MG) 0.0 42 84 126 168 210 WATER (ML) 1.0 1.0 1.0 1.0 1.0 1.0 CALCEIN (MG) 0.2 0.2 0.2 0.2 0.2 0.2 ______________________________________
TABLE 3 ______________________________________ Test Number 1. 2. 3. 4. 5. 6. ______________________________________ INFRA VOL (ML) 1.6 1.5 1.5 1.0 0.95 0.95 LAYER VOL (ML) 0.9 1.0 1.0 1.5 1.6 1.6 WATER UPTAKE (ML) 0.4 0.5 0.5 1.0 1.1 1.1 ______________________________________
TABLE 4 ______________________________________ Cholesterol Surfactant + Mixture ______________________________________ Polyoxyethylene (10) Cetyl Ether - Solution Polyoxyethylene (10) Cetyl Ether + Lipid Vesicles Polyoxyethylene (2) Stearyl Ether - Gel Polyoxyethylene (2) Stearyl Ether + Lipid Vesicles Polyoxyethylene (4) Stearyl Ether - Gel Polyoxyethylene (4) Stearyl Ether + Lipid Vesicles Polyoxyethylene (10) Stearyl Ether - Gel Polyoxyethylene (10) Stearyl Ether + Liposome Polyoxyethylene (20) Stearyl Ether - Gel Polyoxyethylene (20) Stearyl Ether + Gel Polyoxyethylene (2) Oleyl Ether - Separate Bulk Phases Polyoxyethylene (2) Oleyl Ether + Lipid Vesicles Polyoxyethylene (5) Oleyl Ether - Separate Bulk Phases Polyoxyethylene (5) Oleyl Ether + Lipid Vesicles Polyoxyethylene (10) Oleyl Ether - Separate Bulk Phases Polyoxyethylene (10) Oleyl Ether + Lipid Vesicles Polyoxyethylene (5) Oleyl Amine - Turbid Solution Polyoxyethylene (5) Oleyl Amine + Lipid Vesicles Polyoxyethylene (2) Oleyl Amine - Turbid Solution Polyoxyethylene (2) Oleyl Amine + Turbid Solution ______________________________________
Claims (8)
Priority Applications (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/124,824 US4917951A (en) | 1987-07-28 | 1987-11-24 | Lipid vesicles formed of surfactants and steroids |
AU15438/88A AU603659B2 (en) | 1987-03-13 | 1988-03-08 | Lipid vesicles formed of surfactants and steroids |
EP88903061A EP0349579B1 (en) | 1987-03-13 | 1988-03-08 | Lipid vesicles formed of surfactants and steroids |
PCT/US1988/000722 WO1988006882A1 (en) | 1987-03-13 | 1988-03-08 | Lipid vesicles formed of surfactants and steroids |
JP63502979A JP2617346B2 (en) | 1987-03-13 | 1988-03-08 | Lipid vesicles formed from surfactants and steroids |
AT88903061T ATE71292T1 (en) | 1987-03-13 | 1988-03-08 | LIPID VERSIKES OF SURFACE ACTIVE SUBSTANCES AND STEROLS. |
DE8888903061T DE3867635D1 (en) | 1987-03-13 | 1988-03-08 | LIPID VERSICLE FROM INTERFACE-ACTIVE SUBSTANCES AND STEROLS. |
CA000561289A CA1311415C (en) | 1987-03-13 | 1988-03-11 | Lipid vesicles formed of surfactants and steroids |
KR1019880701437A KR890700338A (en) | 1987-03-13 | 1988-11-10 | Lipid vesicle with surfactant and steroid |
DK633188A DK633188A (en) | 1987-03-13 | 1988-11-11 | lipid vesicles |
NO88885036A NO885036L (en) | 1987-03-13 | 1988-11-11 | LIPID VESICLES OF SURFACE ACTIVE SUBSTANCES AND STEROIDS. |
US07/287,108 US5023086A (en) | 1987-03-13 | 1988-12-20 | Encapsulated ionophore growth factors |
US07/300,079 US5000960A (en) | 1987-03-13 | 1989-01-19 | Protein coupling to lipid vesicles |
US07/443,516 US5147723A (en) | 1987-07-28 | 1989-11-29 | Paucilamellar lipid vesicles |
US07/759,732 US5234767A (en) | 1987-03-13 | 1991-09-12 | Hybrid paucilamellar lipid vesicles |
US08/200,351 US5474848A (en) | 1987-03-13 | 1994-02-03 | Paucilamellar lipid vesicles |
US08/456,283 US5628936A (en) | 1987-03-13 | 1995-05-31 | Hybrid paucilamellar lipid vesicles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/078,658 US4855090A (en) | 1987-03-13 | 1987-07-28 | Method of producing high aqueous volume multilamellar vesicles |
US07/124,824 US4917951A (en) | 1987-07-28 | 1987-11-24 | Lipid vesicles formed of surfactants and steroids |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/078,658 Continuation-In-Part US4855090A (en) | 1987-03-13 | 1987-07-28 | Method of producing high aqueous volume multilamellar vesicles |
Related Child Applications (11)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US2552587A Continuation-In-Part | 1987-03-13 | 1987-03-13 | |
US07/078,658 Continuation-In-Part US4855090A (en) | 1987-03-13 | 1987-07-28 | Method of producing high aqueous volume multilamellar vesicles |
US07/157,571 Continuation-In-Part US4911928A (en) | 1987-03-13 | 1988-03-03 | Paucilamellar lipid vesicles |
US07371575 Continuation-In-Part | 1988-03-03 | ||
US07/234,309 Continuation-In-Part US4942038A (en) | 1987-03-13 | 1988-08-19 | Encapsulated humectant |
US07/286,731 Continuation-In-Part US5019392A (en) | 1988-03-03 | 1988-12-20 | Encapsulation of parasiticides |
US07/287,108 Continuation-In-Part US5023086A (en) | 1987-03-13 | 1988-12-20 | Encapsulated ionophore growth factors |
US07/371,738 Continuation-In-Part US5104736A (en) | 1988-03-03 | 1989-06-26 | Reinforced paucilamellar lipid vesicles |
US07/443,516 Continuation-In-Part US5147723A (en) | 1987-03-13 | 1989-11-29 | Paucilamellar lipid vesicles |
US07/759,732 Continuation-In-Part US5234767A (en) | 1987-03-13 | 1991-09-12 | Hybrid paucilamellar lipid vesicles |
US08/456,283 Continuation-In-Part US5628936A (en) | 1987-03-13 | 1995-05-31 | Hybrid paucilamellar lipid vesicles |
Publications (1)
Publication Number | Publication Date |
---|---|
US4917951A true US4917951A (en) | 1990-04-17 |
Family
ID=26760807
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US07/124,824 Expired - Lifetime US4917951A (en) | 1987-03-13 | 1987-11-24 | Lipid vesicles formed of surfactants and steroids |
Country Status (1)
Country | Link |
---|---|
US (1) | US4917951A (en) |
Cited By (152)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5013497A (en) * | 1988-03-03 | 1991-05-07 | Micro-Pak, Inc. | Method and apparatus for producing lipid vesicles |
US5023086A (en) * | 1987-03-13 | 1991-06-11 | Micro-Pak, Inc. | Encapsulated ionophore growth factors |
US5091111A (en) * | 1990-09-19 | 1992-02-25 | S. C. Johnson & Son, Inc. | Aqueous emulsion and aersol delivery system using same |
US5141751A (en) * | 1988-06-29 | 1992-08-25 | Daiichi Pharmaceutical Co., Ltd. | Lipid membrane structures |
US5145604A (en) * | 1990-09-19 | 1992-09-08 | S. C. Johnson & Son, Inc. | Aqueous emulsion and aerosol delivery system using same |
US5147723A (en) * | 1987-07-28 | 1992-09-15 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
US5164191A (en) * | 1991-02-12 | 1992-11-17 | Micro Vesicular Systems, Inc. | Lipid vesicles having an alkyd as a wall-forming material |
WO1993005767A1 (en) * | 1991-09-17 | 1993-04-01 | Micro Vesicular Systems, Inc. | Blended lipid vesicles |
US5213805A (en) * | 1991-07-25 | 1993-05-25 | Micro Vesicular Systems, Inc. | Lipid vesicles having n,n-dimethylamide derivatives as their primary lipid |
US5229104A (en) * | 1991-04-29 | 1993-07-20 | Richardson-Vicks Inc. | Artificial tanning compositions containing positively charged paucilamellar vesicles |
US5234767A (en) * | 1987-03-13 | 1993-08-10 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
US5290565A (en) * | 1989-04-06 | 1994-03-01 | L'oreal | Composition for promoting healing |
US5328628A (en) * | 1990-09-06 | 1994-07-12 | S. C. Johnson & Son, Inc. | Detergent compositions containing liposomes and process therefor |
US5405615A (en) * | 1991-09-17 | 1995-04-11 | Micro Vesicular Systems, Inc. | Sucrose distearate lipid vesicles |
US5439967A (en) * | 1991-09-17 | 1995-08-08 | Micro Vesicular Systems, Inc. | Propylene glycol stearate vesicles |
US5443839A (en) * | 1988-03-09 | 1995-08-22 | Lvmh Recherche | Liposomes containing scutellaria extracts |
US5474848A (en) * | 1987-03-13 | 1995-12-12 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
US5561062A (en) * | 1993-01-15 | 1996-10-01 | Micro-Pak, Inc. | Method of inhibiting viral reproduction using non-phospholipid, paucilamellar liposomes |
US5628936A (en) * | 1987-03-13 | 1997-05-13 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
US5665380A (en) * | 1993-12-17 | 1997-09-09 | Micro-Pak, Inc. | Lipid vesicle fusion as a method of transmitting a biologically active material to a cell |
US5846551A (en) * | 1996-06-10 | 1998-12-08 | E-L Management Corp. | Water-based makeup compositions and methods for their preparation |
US6039960A (en) * | 1997-05-28 | 2000-03-21 | E-L Management Corp. | Water containing wax-based product |
US20020061281A1 (en) * | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US20020197212A1 (en) * | 1999-07-06 | 2002-12-26 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US6506262B2 (en) | 1998-04-08 | 2003-01-14 | Kimberly-Clark Worldwide, Inc. | Cleanser |
US20040087564A1 (en) * | 2002-10-31 | 2004-05-06 | Wright D. Craig | Delivery composition and method |
WO2007041627A1 (en) | 2005-10-03 | 2007-04-12 | Pinsky Mark A | Compositions and methods for improved skin care |
US20080020997A1 (en) * | 2004-04-07 | 2008-01-24 | University Of Georgia Research Foundation, Inc. | Glucosamine and Glucosamine/Anti-Inflammatory Mutual Prodrugs, Compositions, and Methods |
US20090029938A1 (en) * | 2003-09-29 | 2009-01-29 | Topigen Pharmaceutique Inc. | Oligonucleotide compositions and methods for treating disease including inflammatory conditions |
US20090169615A1 (en) * | 2007-12-26 | 2009-07-02 | Pinsky Mark A | Collagen Formulations for Improved Skin Care |
US20090186074A1 (en) * | 2008-01-22 | 2009-07-23 | Nadya Lawrence | Lipid vesicles derived from olive oil fatty acids |
US20090215861A1 (en) * | 2004-10-29 | 2009-08-27 | Topigen Pharmaceuticals Inc. | Antisense oligonucleotides for treating allergy and neoplastic cell proliferation |
WO2009137912A1 (en) | 2008-05-15 | 2009-11-19 | Topigen Pharmaceuticals Inc. | Oligonucleotides for treating inflammation and neoplastic cell proliferation |
US20100048673A1 (en) * | 2006-05-19 | 2010-02-25 | Topigen Pharmaceuticals Inc. | Oligonucleotides affecting expression of phosphodiesterases |
US20100098752A1 (en) * | 2007-01-18 | 2010-04-22 | Pinsky Mark A | Materials and Methods for Delivering Antioxidants into the Skin |
US20100137437A1 (en) * | 2006-05-19 | 2010-06-03 | Viroblock S.A. | Composition for Inactivating an Enveloped Virus |
US20110105961A1 (en) * | 2008-05-23 | 2011-05-05 | Gruber Lewis S | Methods, compositions and apparatuses for facilitating regeneration |
US20110229544A1 (en) * | 2008-11-26 | 2011-09-22 | Viroblock S.A. | Methods for Inhibiting Gram-Postive Bacteria Using Non-Phospholipid Lipid Vesicules |
WO2012075337A2 (en) | 2010-12-01 | 2012-06-07 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
WO2012174446A1 (en) | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer |
US8361990B2 (en) | 2004-04-07 | 2013-01-29 | University Of Georgia Research Foundation, Inc. | Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods |
US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
WO2016036918A1 (en) | 2014-09-03 | 2016-03-10 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
WO2017015433A2 (en) | 2015-07-23 | 2017-01-26 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and b-cell activating factor (baff) and uses thereof |
WO2017019636A1 (en) * | 2015-07-24 | 2017-02-02 | Insmed Incorporated | Compositions and methods for the treatment of sarcoidosis |
EP3127549A1 (en) | 2007-06-22 | 2017-02-08 | Children's Medical Center Corporation | Methods and uses thereof of a fragment of saposin a |
WO2017065837A1 (en) | 2015-10-13 | 2017-04-20 | Siwa Corporation | Anti-age antibodies and methods of use thereof |
US9644207B2 (en) | 2013-03-14 | 2017-05-09 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating Tau expression |
US9649376B2 (en) | 2010-09-27 | 2017-05-16 | Siwa Corporation | Selective removal of age-modified cells for treatment of atherosclerosis |
US9683235B2 (en) | 2013-07-19 | 2017-06-20 | Ionis Pharmaceuticals, Inc. | Compositions for modulating Tau expression |
WO2017143073A1 (en) | 2016-02-19 | 2017-08-24 | Siwa Corporation | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age) |
WO2017181116A1 (en) | 2016-04-15 | 2017-10-19 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
WO2017214447A1 (en) | 2016-06-08 | 2017-12-14 | Children's Medical Center Corporation | Engineered botulinum neurotoxins |
WO2017222535A1 (en) | 2016-06-23 | 2017-12-28 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
WO2018009903A2 (en) | 2016-07-08 | 2018-01-11 | Children's Medical Center Corporation | A novel botulinum neurotoxin and its derivatives |
US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
WO2018119354A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Gene editing of pcsk9 |
WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
EP3366695A1 (en) | 2009-12-17 | 2018-08-29 | Children's Medical Center, Corp. | Saposin-a derived peptides and uses thereof |
WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
WO2018191718A1 (en) | 2017-04-13 | 2018-10-18 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
US10113163B2 (en) | 2016-08-03 | 2018-10-30 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
WO2019067815A2 (en) | 2017-09-29 | 2019-04-04 | Children's Medical Center Corporation | A neurotoxin-like toxin and uses thereof |
WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
US10273474B2 (en) | 2012-03-30 | 2019-04-30 | Washington University | Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome |
US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
WO2019168953A1 (en) | 2018-02-27 | 2019-09-06 | President And Fellows Of Harvard College | Evolved cas9 variants and uses thereof |
US10407680B2 (en) | 2016-09-29 | 2019-09-10 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing Tau expression |
US10435682B2 (en) | 2016-02-19 | 2019-10-08 | University Of South Florida | Arginine deiminase gene therapy for disordered proteins |
EP3560509A1 (en) | 2011-12-22 | 2019-10-30 | Children's Medical Center Corporation | Saposin-a derived peptides and uses thereof |
US10465176B2 (en) | 2013-12-12 | 2019-11-05 | President And Fellows Of Harvard College | Cas variants for gene editing |
US10487324B2 (en) | 2015-02-25 | 2019-11-26 | Washington University | Methods to detect motor neuron disease comprising micro-RNAs |
WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
US10508298B2 (en) | 2013-08-09 | 2019-12-17 | President And Fellows Of Harvard College | Methods for identifying a target site of a CAS9 nuclease |
US10507226B1 (en) | 2018-05-02 | 2019-12-17 | University Of South Florida | N-amino peptide beta-sheet mimics for the treatment of Alzheimer's disease |
US10538553B2 (en) | 2018-01-05 | 2020-01-21 | University Of South Florida | Compounds for the treatment of neurodegenerative diseases |
WO2020023532A1 (en) | 2018-07-23 | 2020-01-30 | Siwa Corporation | Methods and compositions for treating chronic effects of radiation and chemical exposure |
US10584180B2 (en) | 2014-09-19 | 2020-03-10 | Siwa Corporation | Anti-AGE antibodies for treating inflammation and auto-immune disorders |
WO2020051360A1 (en) | 2018-09-05 | 2020-03-12 | The Broad Institute, Inc. | Base editing for treating hutchinson-gilford progeria syndrome |
US10597679B2 (en) | 2013-09-06 | 2020-03-24 | President And Fellows Of Harvard College | Switchable Cas9 nucleases and uses thereof |
WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
WO2020102659A1 (en) | 2018-11-15 | 2020-05-22 | The Broad Institute, Inc. | G-to-t base editors and uses thereof |
US10682410B2 (en) | 2013-09-06 | 2020-06-16 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US10704062B2 (en) | 2014-07-30 | 2020-07-07 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
WO2020181195A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through adenine excision |
WO2020181180A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | A:t to c:g base editors and uses thereof |
WO2020181202A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | A:t to t:a base editing through adenine deamination and oxidation |
WO2020181178A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through thymine alkylation |
WO2020181193A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through adenosine methylation |
WO2020191171A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
WO2020210751A1 (en) | 2019-04-12 | 2020-10-15 | The Broad Institute, Inc. | System for genome editing |
WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
WO2020236982A1 (en) | 2019-05-20 | 2020-11-26 | The Broad Institute, Inc. | Aav delivery of nucleobase editors |
US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
US10858639B2 (en) | 2013-09-06 | 2020-12-08 | President And Fellows Of Harvard College | CAS9 variants and uses thereof |
WO2021025750A1 (en) | 2019-08-08 | 2021-02-11 | The Broad Institute, Inc. | Base editors with diversified targeting scope |
WO2021030666A1 (en) | 2019-08-15 | 2021-02-18 | The Broad Institute, Inc. | Base editing by transglycosylation |
US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
US10945954B2 (en) | 2012-02-06 | 2021-03-16 | President And Fellows Of Harvard College | ARRDC1-mediated microvesicles (ARMMS) and uses thereof |
WO2021050512A1 (en) | 2019-09-09 | 2021-03-18 | Beam Therapeutics Inc. | Novel crispr enzymes, methods, systems and uses thereof |
US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
US11001817B2 (en) | 2014-10-31 | 2021-05-11 | President And Fellows Of Harvard College | Delivery of cargo proteins via ARRDC1-mediated microvesicles (ARMMs) |
WO2021108717A2 (en) | 2019-11-26 | 2021-06-03 | The Broad Institute, Inc | Systems and methods for evaluating cas9-independent off-target editing of nucleic acids |
WO2021113494A1 (en) | 2019-12-03 | 2021-06-10 | Beam Therapeutics Inc. | Synthetic guide rna, compositions, methods, and uses thereof |
US11046948B2 (en) | 2013-08-22 | 2021-06-29 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
WO2021155065A1 (en) | 2020-01-28 | 2021-08-05 | The Broad Institute, Inc. | Base editors, compositions, and methods for modifying the mitochondrial genome |
WO2021158921A2 (en) | 2020-02-05 | 2021-08-12 | The Broad Institute, Inc. | Adenine base editors and uses thereof |
WO2021158999A1 (en) | 2020-02-05 | 2021-08-12 | The Broad Institute, Inc. | Gene editing methods for treating spinal muscular atrophy |
WO2021222318A1 (en) | 2020-04-28 | 2021-11-04 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
WO2021222758A1 (en) | 2020-05-01 | 2021-11-04 | Siwa Corporation | Methods of treating infections |
US11214780B2 (en) | 2015-10-23 | 2022-01-04 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
US11268082B2 (en) | 2017-03-23 | 2022-03-08 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
US11306324B2 (en) | 2016-10-14 | 2022-04-19 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
WO2022093195A1 (en) | 2020-10-27 | 2022-05-05 | Siwa Corporation | Methods and compositions for treating osteoarthritis using anti-age antibodies or age antigens |
WO2022094051A2 (en) | 2020-10-28 | 2022-05-05 | Children's Medical Center Corporation | Truncated modified recombinant adamts13 and uses thereof |
WO2022125776A2 (en) | 2020-12-09 | 2022-06-16 | Siwa Corporation | Methods and compositions for treating kidney diseases |
WO2022178307A1 (en) | 2021-02-19 | 2022-08-25 | Beam Therapeutics Inc. | Recombinant rabies viruses for gene therapy |
WO2022204268A2 (en) | 2021-03-23 | 2022-09-29 | Beam Therapeutics Inc. | Novel crispr enzymes, methods, systems and uses thereof |
WO2022221699A1 (en) | 2021-04-16 | 2022-10-20 | Beam Therapeutics, Inc. | Genetic modification of hepatocytes |
US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
WO2022256578A2 (en) | 2021-06-02 | 2022-12-08 | Beam Therapeutics Inc. | Circular guide rnas for crispr/cas editing systems |
WO2022261509A1 (en) | 2021-06-11 | 2022-12-15 | The Broad Institute, Inc. | Improved cytosine to guanine base editors |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
WO2023004409A1 (en) | 2021-07-23 | 2023-01-26 | Beam Therapeutics Inc. | Guide rnas for crispr/cas editing systems |
WO2023023654A1 (en) | 2021-08-20 | 2023-02-23 | Siwa Corporation | Methods and compositions for treating fibrotic diseases |
WO2023039468A1 (en) | 2021-09-08 | 2023-03-16 | Beam Therapeutics Inc. | Viral guide rna delivery |
DE112021002672T5 (en) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EDIT BOTH STRANDS SIMULTANEOUSLY OF A DOUBLE STRANDED NUCLEOTIDE TARGET SEQUENCE |
WO2023076898A1 (en) | 2021-10-25 | 2023-05-04 | The Broad Institute, Inc. | Methods and compositions for editing a genome with prime editing and a recombinase |
WO2023081756A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
WO2023094435A1 (en) | 2021-11-23 | 2023-06-01 | Cellectis Sa | New tale protein scaffolds with improved on-target/off-target activity ratios |
WO2023102537A2 (en) | 2021-12-03 | 2023-06-08 | The Broad Institute, Inc. | Self-assembling virus-like particles for delivery of nucleic acid programmable fusion proteins and methods of making and using same |
WO2023102538A1 (en) | 2021-12-03 | 2023-06-08 | The Broad Institute, Inc. | Self-assembling virus-like particles for delivery of prime editors and methods of making and using same |
WO2023114953A2 (en) | 2021-12-17 | 2023-06-22 | Beam Therapeutics Inc. | Novel crispr enzymes, methods, systems and uses thereof |
US11730823B2 (en) | 2016-10-03 | 2023-08-22 | President And Fellows Of Harvard College | Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles |
WO2023196802A1 (en) | 2022-04-04 | 2023-10-12 | The Broad Institute, Inc. | Cas9 variants having non-canonical pam specificities and uses thereof |
WO2023196772A1 (en) | 2022-04-04 | 2023-10-12 | Beam Therapeutics Inc. | Novel rna base editing compositions, systems, methods and uses thereof |
WO2023205687A1 (en) | 2022-04-20 | 2023-10-26 | The Broad Institute, Inc. | Improved prime editing methods and compositions |
WO2023212715A1 (en) | 2022-04-28 | 2023-11-02 | The Broad Institute, Inc. | Aav vectors encoding base editors and uses thereof |
WO2023230613A1 (en) | 2022-05-27 | 2023-11-30 | The Broad Institute, Inc. | Improved mitochondrial base editors and methods for editing mitochondrial dna |
WO2023240137A1 (en) | 2022-06-08 | 2023-12-14 | The Board Institute, Inc. | Evolved cas14a1 variants, compositions, and methods of making and using same in genome editing |
WO2024040083A1 (en) | 2022-08-16 | 2024-02-22 | The Broad Institute, Inc. | Evolved cytosine deaminases and methods of editing dna using same |
WO2024059791A1 (en) | 2022-09-16 | 2024-03-21 | Beam Therapeutics Inc. | Large serine recombinases, systems and uses thereof |
WO2024077267A1 (en) | 2022-10-07 | 2024-04-11 | The Broad Institute, Inc. | Prime editing methods and compositions for treating triplet repeat disorders |
Citations (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3372201A (en) * | 1966-06-17 | 1968-03-05 | Gen Aniline & Film Corp | Alkoxylation of secondary alcohols |
US3957971A (en) * | 1974-07-29 | 1976-05-18 | Lever Brothers Company | Moisturizing units and moisturizing compositions containing the same |
US4133874A (en) * | 1976-06-10 | 1979-01-09 | The University Of Illinois Foundation | Lipid encapsulated hemoglobin cells |
GB1539625A (en) * | 1975-06-30 | 1979-01-31 | Oreal | Process for preparing aqueous dispersions of lipid spherules and aqueous dispersions of such lipid spherules |
US4217344A (en) * | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
US4241046A (en) * | 1978-11-30 | 1980-12-23 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4247411A (en) * | 1978-02-02 | 1981-01-27 | L'oreal | Storage stability of aqueous dispersions of spherules |
EP0032578A1 (en) * | 1980-01-16 | 1981-07-29 | Hans Georg Prof. Dr. Weder | Process and dialysis-installation for the preparation of bilayer-vesicles and their use |
GB2078543A (en) * | 1980-07-01 | 1982-01-13 | Oreal | Process for the preparation of stable dispersions of at least one water-immiscible liquid phase in an aqueous phase |
GB2079179A (en) * | 1980-07-01 | 1982-01-20 | Oreal | Cosmetic Composition Based On an Aqueous Dispersion of Small Lipid Spheres |
US4348329A (en) * | 1979-12-20 | 1982-09-07 | Dennis Chapman | Biocompatible surfaces |
US4356167A (en) * | 1978-01-27 | 1982-10-26 | Sandoz, Inc. | Liposome drug delivery systems |
US4377567A (en) * | 1978-10-02 | 1983-03-22 | The Procter & Gamble Company | Lipid membrane drug delivery |
JPS59106423A (en) * | 1982-12-08 | 1984-06-20 | Hiroshi Kiwada | Liposome |
DE3410602A1 (en) * | 1983-03-22 | 1984-09-27 | L'oreal, Paris | METHOD FOR PRODUCING LIPID VIALS BY EVAPORATING SOLVENTS AND DEVICE FOR CARRYING OUT THIS METHOD |
US4485054A (en) * | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
WO1985001440A1 (en) * | 1983-10-06 | 1985-04-11 | Centre National De La Recherche Scientifique (C.N. | Preparation of unilamella liposomes of large diameters |
GB2147263A (en) * | 1983-09-29 | 1985-05-09 | Kao Corp | Compositions for making vesicles |
US4536324A (en) * | 1982-07-19 | 1985-08-20 | Lion Corporation | Nonionic surfactant type vesicle dispersion |
US4551288A (en) * | 1982-08-16 | 1985-11-05 | Sandoz, Inc. | Processes for the preparation of liposome drug delivery systems |
US4564599A (en) * | 1982-08-23 | 1986-01-14 | The Liposome Company, Inc. | Liposome composition for lupus assay |
GB2166107A (en) * | 1984-10-24 | 1986-04-30 | Oreal | Lipid spherule composition and process for its preparation |
US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
JPS61207324A (en) * | 1985-03-11 | 1986-09-13 | Agency Of Ind Science & Technol | Liposome |
US4619913A (en) * | 1984-05-29 | 1986-10-28 | Matrix Pharmaceuticals, Inc. | Treatments employing drug-containing matrices for introduction into cellular lesion areas |
US4666711A (en) * | 1979-09-18 | 1987-05-19 | L'oreal | Non-ionic surface-active agents and compositions in which they are present |
US4684625A (en) * | 1982-07-08 | 1987-08-04 | Syntex (U.S.A.) Inc. | Method for enhancing the anti-infective activity of muramyldipeptide derivatives |
US4692433A (en) * | 1983-10-12 | 1987-09-08 | The Regents Of The University Of California | Method and composition for regulating serum calcium levels of mammals |
US4695554A (en) * | 1984-02-14 | 1987-09-22 | Becton Dickinson And Company | Sac or liposome containing dye (sulforhodamine) for immunoassay |
US4725442A (en) * | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
US4731210A (en) * | 1981-01-07 | 1988-03-15 | Hans Georg Weder | Process for the preparation of liposomal medicaments |
US4772471A (en) * | 1975-06-30 | 1988-09-20 | Societe Anonyme Dite: L'oreal | Aqueous dispersions of lipid spheres and compositions containing the same |
-
1987
- 1987-11-24 US US07/124,824 patent/US4917951A/en not_active Expired - Lifetime
Patent Citations (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3372201A (en) * | 1966-06-17 | 1968-03-05 | Gen Aniline & Film Corp | Alkoxylation of secondary alcohols |
US3957971A (en) * | 1974-07-29 | 1976-05-18 | Lever Brothers Company | Moisturizing units and moisturizing compositions containing the same |
GB1539625A (en) * | 1975-06-30 | 1979-01-31 | Oreal | Process for preparing aqueous dispersions of lipid spherules and aqueous dispersions of such lipid spherules |
US4772471A (en) * | 1975-06-30 | 1988-09-20 | Societe Anonyme Dite: L'oreal | Aqueous dispersions of lipid spheres and compositions containing the same |
US4133874A (en) * | 1976-06-10 | 1979-01-09 | The University Of Illinois Foundation | Lipid encapsulated hemoglobin cells |
US4217344A (en) * | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
US4356167A (en) * | 1978-01-27 | 1982-10-26 | Sandoz, Inc. | Liposome drug delivery systems |
US4247411A (en) * | 1978-02-02 | 1981-01-27 | L'oreal | Storage stability of aqueous dispersions of spherules |
US4377567A (en) * | 1978-10-02 | 1983-03-22 | The Procter & Gamble Company | Lipid membrane drug delivery |
US4241046A (en) * | 1978-11-30 | 1980-12-23 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
US4666711A (en) * | 1979-09-18 | 1987-05-19 | L'oreal | Non-ionic surface-active agents and compositions in which they are present |
US4348329A (en) * | 1979-12-20 | 1982-09-07 | Dennis Chapman | Biocompatible surfaces |
EP0032578A1 (en) * | 1980-01-16 | 1981-07-29 | Hans Georg Prof. Dr. Weder | Process and dialysis-installation for the preparation of bilayer-vesicles and their use |
GB2078543A (en) * | 1980-07-01 | 1982-01-13 | Oreal | Process for the preparation of stable dispersions of at least one water-immiscible liquid phase in an aqueous phase |
GB2079179A (en) * | 1980-07-01 | 1982-01-20 | Oreal | Cosmetic Composition Based On an Aqueous Dispersion of Small Lipid Spheres |
US4731210A (en) * | 1981-01-07 | 1988-03-15 | Hans Georg Weder | Process for the preparation of liposomal medicaments |
US4684625A (en) * | 1982-07-08 | 1987-08-04 | Syntex (U.S.A.) Inc. | Method for enhancing the anti-infective activity of muramyldipeptide derivatives |
US4536324A (en) * | 1982-07-19 | 1985-08-20 | Lion Corporation | Nonionic surfactant type vesicle dispersion |
US4551288A (en) * | 1982-08-16 | 1985-11-05 | Sandoz, Inc. | Processes for the preparation of liposome drug delivery systems |
US4564599A (en) * | 1982-08-23 | 1986-01-14 | The Liposome Company, Inc. | Liposome composition for lupus assay |
US4485054A (en) * | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
JPS59106423A (en) * | 1982-12-08 | 1984-06-20 | Hiroshi Kiwada | Liposome |
US4608211A (en) * | 1983-03-22 | 1986-08-26 | L'oreal | Process for preparing lipid vesicles by vaporisation of solvents |
DE3410602A1 (en) * | 1983-03-22 | 1984-09-27 | L'oreal, Paris | METHOD FOR PRODUCING LIPID VIALS BY EVAPORATING SOLVENTS AND DEVICE FOR CARRYING OUT THIS METHOD |
US4725442A (en) * | 1983-06-17 | 1988-02-16 | Haynes Duncan H | Microdroplets of water-insoluble drugs and injectable formulations containing same |
GB2147263A (en) * | 1983-09-29 | 1985-05-09 | Kao Corp | Compositions for making vesicles |
WO1985001440A1 (en) * | 1983-10-06 | 1985-04-11 | Centre National De La Recherche Scientifique (C.N. | Preparation of unilamella liposomes of large diameters |
US4692433A (en) * | 1983-10-12 | 1987-09-08 | The Regents Of The University Of California | Method and composition for regulating serum calcium levels of mammals |
US4695554A (en) * | 1984-02-14 | 1987-09-22 | Becton Dickinson And Company | Sac or liposome containing dye (sulforhodamine) for immunoassay |
US4610868A (en) * | 1984-03-20 | 1986-09-09 | The Liposome Company, Inc. | Lipid matrix carriers for use in drug delivery systems |
US4619913A (en) * | 1984-05-29 | 1986-10-28 | Matrix Pharmaceuticals, Inc. | Treatments employing drug-containing matrices for introduction into cellular lesion areas |
GB2166107A (en) * | 1984-10-24 | 1986-04-30 | Oreal | Lipid spherule composition and process for its preparation |
JPS61207324A (en) * | 1985-03-11 | 1986-09-13 | Agency Of Ind Science & Technol | Liposome |
Non-Patent Citations (24)
Title |
---|
"A very mild Method Allowing the Encapsulation of very High Amounts of Macromolecules into very Large (100 nm) Unilamellar Liposomes," Philippot et al., Biochem. Biophys. Acta, 734:137-143, (1983). |
"Bilayer Fluidity of non-ionic Vesicles, An Investigation by Differential Polarized Phase Fluorometry," Ribier and Handjani-Vila, Colloids and Surfaces, 10:155-161, (1984). |
"Extemporaneous Preparation of Large Unilamellar Liposomes," Philippot et al., Biochem. Biophys. Acta, 821:79-84, (1985). |
"Les niosomes," Handjani-Vila et al., Les Liposomes, Puisieux and Delattre, Eds. Techniques et Documentation La Voisier Paris, p. 297-313, (1985). |
"Liposomes," Edited by Marc J. Ostro, The Liposome Co., Princeton, NJ, Marcel Dekker, Inc., New York, p. 246-249, (1983). |
"Methodes de preparation des liposomes," Dousset and Douste-Blazy, Les Liposomes, Puisieux and Delattre, Eds. Techniques et Documentation La Voisier Paris, p. 41-72, (1985). |
"Non-ionic Surfactant Vesicles, Niosomes, as a Delivery system for the Anti-leishmanial Drug, Sodium Stibogluconate," Baillie et al., J. Pharm. Pharmacol., 38:502-505, (1986). |
"Problemes technologiques poses par l'utilisation des liposomes comme vecteurs de substances medicamenteuses, Encapsulation, sterilisation, conservation," Puisieux and Poly, Les Liposomes, Puisieux and Delattre, Eds. Techniques et Documentation La Voisier Paris, p. 73-113, (1985). |
"Procedure for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse-Phase Evaporation," |
"The Preparation and Properties of Niosomes-non-ionic Surfactant Vesicles," Baillie et al., J. Pharm. Pharmacol., 37:863-868, (1985). |
A very mild Method Allowing the Encapsulation of very High Amounts of Macromolecules into very Large (100 nm) Unilamellar Liposomes, Philippot et al., Biochem. Biophys. Acta, 734:137 143, (1983). * |
Bilayer Fluidity of non ionic Vesicles, An Investigation by Differential Polarized Phase Fluorometry, Ribier and Handjani Vila, Colloids and Surfaces, 10:155 161, (1984). * |
Extemporaneous Preparation of Large Unilamellar Liposomes, Philippot et al., Biochem. Biophys. Acta, 821:79 84, (1985). * |
Les niosomes, Handjani Vila et al., Les Liposomes, Puisieux and Delattre, Eds. Techniques et Documentation La Voisier Paris, p. 297 313, (1985). * |
Liposomes, Edited by Marc J. Ostro, The Liposome Co., Princeton, NJ, Marcel Dekker, Inc., New York, p. 246 249, (1983). * |
McCutcheon s Detergents & Emulsifiers 1973 No. American Edition Publ. by McCutchen s Division, Allured Publishing Co., Ridgewood, NJ, (1973), p. 27 TP 990 .D4 . * |
McCutcheon's Detergents & Emulsifiers-1973 No. American Edition Publ. by McCutchen's Division, Allured Publishing Co., Ridgewood, NJ, (1973), p. 27 [TP 990 .D4]. |
Methodes de preparation des liposomes, Dousset and Douste Blazy, Les Liposomes, Puisieux and Delattre, Eds. Techniques et Documentation La Voisier Paris, p. 41 72, (1985). * |
Non ionic Surfactant Vesicles, Niosomes, as a Delivery system for the Anti leishmanial Drug, Sodium Stibogluconate, Baillie et al., J. Pharm. Pharmacol., 38:502 505, (1986). * |
Problemes technologiques poses par l utilisation des liposomes comme vecteurs de substances medicamenteuses, Encapsulation, sterilisation, conservation, Puisieux and Poly, Les Liposomes, Puisieux and Delattre, Eds. Techniques et Documentation La Voisier Paris, p. 73 113, (1985). * |
Procedure for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse Phase Evaporation, * |
Szoka, Jr. and Papahadjopoulos, Proc. Natl. Acad. Sci. U.S.A., 75(9):4194 4198, (1978). * |
Szoka, Jr. and Papahadjopoulos, Proc. Natl. Acad. Sci. U.S.A., 75(9):4194-4198, (1978). |
The Preparation and Properties of Niosomes non ionic Surfactant Vesicles, Baillie et al., J. Pharm. Pharmacol., 37:863 868, (1985). * |
Cited By (225)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5628936A (en) * | 1987-03-13 | 1997-05-13 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
US5023086A (en) * | 1987-03-13 | 1991-06-11 | Micro-Pak, Inc. | Encapsulated ionophore growth factors |
US5474848A (en) * | 1987-03-13 | 1995-12-12 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
US5234767A (en) * | 1987-03-13 | 1993-08-10 | Micro-Pak, Inc. | Hybrid paucilamellar lipid vesicles |
US5147723A (en) * | 1987-07-28 | 1992-09-15 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
US5013497A (en) * | 1988-03-03 | 1991-05-07 | Micro-Pak, Inc. | Method and apparatus for producing lipid vesicles |
US5443839A (en) * | 1988-03-09 | 1995-08-22 | Lvmh Recherche | Liposomes containing scutellaria extracts |
US5643598A (en) * | 1988-03-09 | 1997-07-01 | Lvmh Recherche | Method of skin care utilizing liposomes containing Scutellaria extracts |
US5141751A (en) * | 1988-06-29 | 1992-08-25 | Daiichi Pharmaceutical Co., Ltd. | Lipid membrane structures |
US5290565A (en) * | 1989-04-06 | 1994-03-01 | L'oreal | Composition for promoting healing |
US5328628A (en) * | 1990-09-06 | 1994-07-12 | S. C. Johnson & Son, Inc. | Detergent compositions containing liposomes and process therefor |
US5145604A (en) * | 1990-09-19 | 1992-09-08 | S. C. Johnson & Son, Inc. | Aqueous emulsion and aerosol delivery system using same |
US5091111A (en) * | 1990-09-19 | 1992-02-25 | S. C. Johnson & Son, Inc. | Aqueous emulsion and aersol delivery system using same |
US5164191A (en) * | 1991-02-12 | 1992-11-17 | Micro Vesicular Systems, Inc. | Lipid vesicles having an alkyd as a wall-forming material |
US5229104A (en) * | 1991-04-29 | 1993-07-20 | Richardson-Vicks Inc. | Artificial tanning compositions containing positively charged paucilamellar vesicles |
US5213805A (en) * | 1991-07-25 | 1993-05-25 | Micro Vesicular Systems, Inc. | Lipid vesicles having n,n-dimethylamide derivatives as their primary lipid |
US5439967A (en) * | 1991-09-17 | 1995-08-08 | Micro Vesicular Systems, Inc. | Propylene glycol stearate vesicles |
US5405615A (en) * | 1991-09-17 | 1995-04-11 | Micro Vesicular Systems, Inc. | Sucrose distearate lipid vesicles |
AU655072B2 (en) * | 1991-09-17 | 1994-12-01 | Novavax, Inc. | Blended lipid vesicles |
US5260065A (en) * | 1991-09-17 | 1993-11-09 | Micro Vesicular Systems, Inc. | Blended lipid vesicles |
WO1993005767A1 (en) * | 1991-09-17 | 1993-04-01 | Micro Vesicular Systems, Inc. | Blended lipid vesicles |
US5561062A (en) * | 1993-01-15 | 1996-10-01 | Micro-Pak, Inc. | Method of inhibiting viral reproduction using non-phospholipid, paucilamellar liposomes |
US5665380A (en) * | 1993-12-17 | 1997-09-09 | Micro-Pak, Inc. | Lipid vesicle fusion as a method of transmitting a biologically active material to a cell |
US5846551A (en) * | 1996-06-10 | 1998-12-08 | E-L Management Corp. | Water-based makeup compositions and methods for their preparation |
US6280753B1 (en) | 1997-05-28 | 2001-08-28 | E-L Management Corporation | Water containing wax-based product |
US6039960A (en) * | 1997-05-28 | 2000-03-21 | E-L Management Corp. | Water containing wax-based product |
US6506262B2 (en) | 1998-04-08 | 2003-01-14 | Kimberly-Clark Worldwide, Inc. | Cleanser |
US20020061281A1 (en) * | 1999-07-06 | 2002-05-23 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US20020197212A1 (en) * | 1999-07-06 | 2002-12-26 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US20030031631A1 (en) * | 1999-07-06 | 2003-02-13 | Osbakken Robert S. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US7128897B2 (en) | 1999-07-06 | 2006-10-31 | Naryx Pharma, Inc. | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US20070031344A1 (en) * | 1999-07-06 | 2007-02-08 | Osbakken Robert S | Aerosolized anti-infectives, anti-inflammatories, and decongestants for the treatment of sinusitis |
US20040204399A1 (en) * | 2001-08-31 | 2004-10-14 | Osbakken Robert S. | Aerosolized decongestants for the treatment of sinusitis |
US20040087564A1 (en) * | 2002-10-31 | 2004-05-06 | Wright D. Craig | Delivery composition and method |
US20110079528A1 (en) * | 2003-09-29 | 2011-04-07 | Topigen Pharmaceutique Inc. | Oligonucleotide compositions and methods for treating disease including inflammatory conditions |
EP2314595A2 (en) | 2003-09-29 | 2011-04-27 | Topigen Pharmaceuticals Inc. | Oligonucleotide compositions and methods for treating disease including inflammatory conditions |
US20090029938A1 (en) * | 2003-09-29 | 2009-01-29 | Topigen Pharmaceutique Inc. | Oligonucleotide compositions and methods for treating disease including inflammatory conditions |
US8173796B2 (en) | 2003-09-29 | 2012-05-08 | Topigen Pharmaceutique Inc. | Oligonucleotide compositions and methods for treating disease including inflammatory conditions |
US7825236B2 (en) | 2003-09-29 | 2010-11-02 | Topigen Pharmaceutique Inc. | Oligonucleotide compositions and methods for treating disease including inflammatory conditions |
US20080020997A1 (en) * | 2004-04-07 | 2008-01-24 | University Of Georgia Research Foundation, Inc. | Glucosamine and Glucosamine/Anti-Inflammatory Mutual Prodrugs, Compositions, and Methods |
US8361990B2 (en) | 2004-04-07 | 2013-01-29 | University Of Georgia Research Foundation, Inc. | Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods |
US8034796B2 (en) | 2004-04-07 | 2011-10-11 | The University Of Georgia Research Foundation, Inc. | Glucosamine and glucosamine/anti-inflammatory mutual prodrugs, compositions, and methods |
US20090215861A1 (en) * | 2004-10-29 | 2009-08-27 | Topigen Pharmaceuticals Inc. | Antisense oligonucleotides for treating allergy and neoplastic cell proliferation |
US8202851B2 (en) | 2004-10-29 | 2012-06-19 | Topigen Pharmaceuticals Inc. | Antisense oligonucleotides for treating allergy and neoplastic cell proliferation |
US8119790B2 (en) | 2004-10-29 | 2012-02-21 | Topigen Pharmaceuticals Inc. | Antisense oligonucleotides for treating allergy and neoplastic cell proliferation |
EP3015101A1 (en) | 2005-10-03 | 2016-05-04 | PINSKY, Mark A. | Non-phospholipid liposomes comprising hyaluronic acid |
WO2007041627A1 (en) | 2005-10-03 | 2007-04-12 | Pinsky Mark A | Compositions and methods for improved skin care |
US20100137437A1 (en) * | 2006-05-19 | 2010-06-03 | Viroblock S.A. | Composition for Inactivating an Enveloped Virus |
US8889398B2 (en) | 2006-05-19 | 2014-11-18 | Viroblock Sa | Composition for inactivating an enveloped virus |
US7982028B2 (en) | 2006-05-19 | 2011-07-19 | Topigen Pharmaceuticals, Inc. | Oligonucleotides affecting expression of phosphodiesterases |
US20110086901A9 (en) * | 2006-05-19 | 2011-04-14 | Topigen Pharmaceuticals Inc. | Oligonucleotides affecting expression of phosphodiesterases |
US20100048673A1 (en) * | 2006-05-19 | 2010-02-25 | Topigen Pharmaceuticals Inc. | Oligonucleotides affecting expression of phosphodiesterases |
US20100098752A1 (en) * | 2007-01-18 | 2010-04-22 | Pinsky Mark A | Materials and Methods for Delivering Antioxidants into the Skin |
EP3127549A1 (en) | 2007-06-22 | 2017-02-08 | Children's Medical Center Corporation | Methods and uses thereof of a fragment of saposin a |
EP3666284A1 (en) | 2007-06-22 | 2020-06-17 | Children's Medical Center, Corp. | Methods and uses thereof of a fragment of saposin a |
US20090169615A1 (en) * | 2007-12-26 | 2009-07-02 | Pinsky Mark A | Collagen Formulations for Improved Skin Care |
US10350150B2 (en) | 2007-12-26 | 2019-07-16 | Mark A. Pinsky | Collagen formulations for improved skin care |
US10251839B2 (en) | 2008-01-22 | 2019-04-09 | Igi Laboratories, Inc. | Lipid vesicles derived from olive oil fatty acids |
US20090186074A1 (en) * | 2008-01-22 | 2009-07-23 | Nadya Lawrence | Lipid vesicles derived from olive oil fatty acids |
WO2009137912A1 (en) | 2008-05-15 | 2009-11-19 | Topigen Pharmaceuticals Inc. | Oligonucleotides for treating inflammation and neoplastic cell proliferation |
US9161810B2 (en) | 2008-05-23 | 2015-10-20 | Siwa Corporation | Methods, compositions and apparatuses for facilitating regeneration |
US20110105961A1 (en) * | 2008-05-23 | 2011-05-05 | Gruber Lewis S | Methods, compositions and apparatuses for facilitating regeneration |
US11261241B2 (en) | 2008-05-23 | 2022-03-01 | Siwa Corporation | Methods, compositions and apparatuses for facilitating regeneration |
US20110229544A1 (en) * | 2008-11-26 | 2011-09-22 | Viroblock S.A. | Methods for Inhibiting Gram-Postive Bacteria Using Non-Phospholipid Lipid Vesicules |
EP3366695A1 (en) | 2009-12-17 | 2018-08-29 | Children's Medical Center, Corp. | Saposin-a derived peptides and uses thereof |
EP3925670A1 (en) | 2009-12-17 | 2021-12-22 | Children's Medical Center, Corp. | Saposin-a derived peptides and uses thereof |
US10226531B2 (en) | 2010-09-27 | 2019-03-12 | Siwa Corporation | Selective removal of age-modified cells for treatment of atherosclerosis |
US9649376B2 (en) | 2010-09-27 | 2017-05-16 | Siwa Corporation | Selective removal of age-modified cells for treatment of atherosclerosis |
US9320919B2 (en) | 2010-11-22 | 2016-04-26 | Siwa Corporation | Selective removal of cells having accumulated agents |
US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
US10960234B2 (en) | 2010-11-22 | 2021-03-30 | Siwa Corporation | Selective removal of cells having accumulated agents |
WO2012075337A2 (en) | 2010-12-01 | 2012-06-07 | Spinal Modulation, Inc. | Directed delivery of agents to neural anatomy |
WO2012174446A1 (en) | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer |
EP3281640A1 (en) | 2011-06-17 | 2018-02-14 | President and Fellows of Harvard College | Frizzled 2 as a target for therapeutic antibodies in the treatment of cancer |
US10323236B2 (en) | 2011-07-22 | 2019-06-18 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
EP3560509A1 (en) | 2011-12-22 | 2019-10-30 | Children's Medical Center Corporation | Saposin-a derived peptides and uses thereof |
EP4306123A2 (en) | 2011-12-22 | 2024-01-17 | Children's Medical Center Corporation | Saposin-a derived peptides and uses thereof |
US10945954B2 (en) | 2012-02-06 | 2021-03-16 | President And Fellows Of Harvard College | ARRDC1-mediated microvesicles (ARMMS) and uses thereof |
US11781135B2 (en) | 2012-03-30 | 2023-10-10 | Washington University | Methods for treating Alzheimer's disease |
US10273474B2 (en) | 2012-03-30 | 2019-04-30 | Washington University | Methods for modulating Tau expression for reducing seizure and modifying a neurodegenerative syndrome |
US11155815B2 (en) | 2013-03-14 | 2021-10-26 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating Tau expression |
US9644207B2 (en) | 2013-03-14 | 2017-05-09 | Ionis Pharmaceuticals, Inc. | Compositions and methods for modulating Tau expression |
US10793856B2 (en) | 2013-07-19 | 2020-10-06 | Biogen Ma Inc. | Compositions for modulating Tau expression |
US11591595B2 (en) | 2013-07-19 | 2023-02-28 | Biogen Ma Inc. | Compositions for modulating Tau expression |
US9683235B2 (en) | 2013-07-19 | 2017-06-20 | Ionis Pharmaceuticals, Inc. | Compositions for modulating Tau expression |
US10508298B2 (en) | 2013-08-09 | 2019-12-17 | President And Fellows Of Harvard College | Methods for identifying a target site of a CAS9 nuclease |
US11920181B2 (en) | 2013-08-09 | 2024-03-05 | President And Fellows Of Harvard College | Nuclease profiling system |
US10954548B2 (en) | 2013-08-09 | 2021-03-23 | President And Fellows Of Harvard College | Nuclease profiling system |
US11046948B2 (en) | 2013-08-22 | 2021-06-29 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
US10682410B2 (en) | 2013-09-06 | 2020-06-16 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
US10858639B2 (en) | 2013-09-06 | 2020-12-08 | President And Fellows Of Harvard College | CAS9 variants and uses thereof |
US10597679B2 (en) | 2013-09-06 | 2020-03-24 | President And Fellows Of Harvard College | Switchable Cas9 nucleases and uses thereof |
US11299755B2 (en) | 2013-09-06 | 2022-04-12 | President And Fellows Of Harvard College | Switchable CAS9 nucleases and uses thereof |
US10912833B2 (en) | 2013-09-06 | 2021-02-09 | President And Fellows Of Harvard College | Delivery of negatively charged proteins using cationic lipids |
US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
US11124782B2 (en) | 2013-12-12 | 2021-09-21 | President And Fellows Of Harvard College | Cas variants for gene editing |
US10465176B2 (en) | 2013-12-12 | 2019-11-05 | President And Fellows Of Harvard College | Cas variants for gene editing |
US11578343B2 (en) | 2014-07-30 | 2023-02-14 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
US10704062B2 (en) | 2014-07-30 | 2020-07-07 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
WO2016036918A1 (en) | 2014-09-03 | 2016-03-10 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
US10584180B2 (en) | 2014-09-19 | 2020-03-10 | Siwa Corporation | Anti-AGE antibodies for treating inflammation and auto-immune disorders |
US11001817B2 (en) | 2014-10-31 | 2021-05-11 | President And Fellows Of Harvard College | Delivery of cargo proteins via ARRDC1-mediated microvesicles (ARMMs) |
US11827910B2 (en) | 2014-10-31 | 2023-11-28 | President And Fellows Of Harvard College | Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) |
US11872269B2 (en) | 2014-12-18 | 2024-01-16 | Siwa Corporation | Method and composition for treating sarcopenia |
US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
US11873345B2 (en) | 2014-12-18 | 2024-01-16 | Siwa Corporation | Product and method for treating sarcopenia |
US10487324B2 (en) | 2015-02-25 | 2019-11-26 | Washington University | Methods to detect motor neuron disease comprising micro-RNAs |
US11225663B2 (en) | 2015-02-25 | 2022-01-18 | Washington University | Methods to detect motor neuron disease comprising micro-RNAs |
WO2017015433A2 (en) | 2015-07-23 | 2017-01-26 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and b-cell activating factor (baff) and uses thereof |
WO2017019636A1 (en) * | 2015-07-24 | 2017-02-02 | Insmed Incorporated | Compositions and methods for the treatment of sarcoidosis |
WO2017065837A1 (en) | 2015-10-13 | 2017-04-20 | Siwa Corporation | Anti-age antibodies and methods of use thereof |
US11214780B2 (en) | 2015-10-23 | 2022-01-04 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
US11833202B2 (en) | 2016-02-19 | 2023-12-05 | Siwa Corporation | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (AGE) |
EP4067386A1 (en) | 2016-02-19 | 2022-10-05 | Siwa Corporation | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age) |
EP3677598A1 (en) | 2016-02-19 | 2020-07-08 | Siwa Corporation | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age) |
US10435682B2 (en) | 2016-02-19 | 2019-10-08 | University Of South Florida | Arginine deiminase gene therapy for disordered proteins |
WO2017143073A1 (en) | 2016-02-19 | 2017-08-24 | Siwa Corporation | Method and composition for treating cancer, killing metastatic cancer cells and preventing cancer metastasis using antibody to advanced glycation end products (age) |
US11958900B2 (en) | 2016-04-15 | 2024-04-16 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
WO2017181116A1 (en) | 2016-04-15 | 2017-10-19 | Siwa Corporation | Anti-age antibodies for treating neurodegenerative disorders |
WO2017214447A1 (en) | 2016-06-08 | 2017-12-14 | Children's Medical Center Corporation | Engineered botulinum neurotoxins |
US11213585B2 (en) | 2016-06-23 | 2022-01-04 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
WO2017222535A1 (en) | 2016-06-23 | 2017-12-28 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
EP4212545A1 (en) | 2016-07-08 | 2023-07-19 | Children's Medical Center Corporation | A novel botulinum neurotoxin and its derivatives |
WO2018009903A2 (en) | 2016-07-08 | 2018-01-11 | Children's Medical Center Corporation | A novel botulinum neurotoxin and its derivatives |
US10947530B2 (en) | 2016-08-03 | 2021-03-16 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
US10113163B2 (en) | 2016-08-03 | 2018-10-30 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
US11702651B2 (en) | 2016-08-03 | 2023-07-18 | President And Fellows Of Harvard College | Adenosine nucleobase editors and uses thereof |
US11661590B2 (en) | 2016-08-09 | 2023-05-30 | President And Fellows Of Harvard College | Programmable CAS9-recombinase fusion proteins and uses thereof |
US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
US11053498B2 (en) | 2016-09-29 | 2021-07-06 | Biogen Ma Inc. | Compounds and methods for reducing Tau expression |
US10407680B2 (en) | 2016-09-29 | 2019-09-10 | Ionis Pharmaceuticals, Inc. | Compounds and methods for reducing Tau expression |
US11730823B2 (en) | 2016-10-03 | 2023-08-22 | President And Fellows Of Harvard College | Delivery of therapeutic RNAs via ARRDC1-mediated microvesicles |
US11306324B2 (en) | 2016-10-14 | 2022-04-19 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
US11820969B2 (en) | 2016-12-23 | 2023-11-21 | President And Fellows Of Harvard College | Editing of CCR2 receptor gene to protect against HIV infection |
US10745677B2 (en) | 2016-12-23 | 2020-08-18 | President And Fellows Of Harvard College | Editing of CCR5 receptor gene to protect against HIV infection |
WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
WO2018119354A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Gene editing of pcsk9 |
US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
WO2018165629A1 (en) | 2017-03-10 | 2018-09-13 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
US11542496B2 (en) | 2017-03-10 | 2023-01-03 | President And Fellows Of Harvard College | Cytosine to guanine base editor |
US11268082B2 (en) | 2017-03-23 | 2022-03-08 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
US10919957B2 (en) | 2017-04-13 | 2021-02-16 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
WO2018191718A1 (en) | 2017-04-13 | 2018-10-18 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
US11542324B2 (en) | 2017-04-13 | 2023-01-03 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
WO2019023680A1 (en) | 2017-07-28 | 2019-01-31 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
US11732274B2 (en) | 2017-07-28 | 2023-08-22 | President And Fellows Of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE) |
US11932884B2 (en) | 2017-08-30 | 2024-03-19 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
US11319532B2 (en) | 2017-08-30 | 2022-05-03 | President And Fellows Of Harvard College | High efficiency base editors comprising Gam |
WO2019067815A2 (en) | 2017-09-29 | 2019-04-04 | Children's Medical Center Corporation | A neurotoxin-like toxin and uses thereof |
WO2019079347A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
US11795443B2 (en) | 2017-10-16 | 2023-10-24 | The Broad Institute, Inc. | Uses of adenosine base editors |
US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
US10836793B2 (en) | 2018-01-05 | 2020-11-17 | University Of South Florida | Compounds for the treatment of neurodegenerative diseases |
US11254704B2 (en) | 2018-01-05 | 2022-02-22 | University Of South Florida | Compounds and methods for reducing or inhibiting aggregation of proteins in a subject |
US10538553B2 (en) | 2018-01-05 | 2020-01-21 | University Of South Florida | Compounds for the treatment of neurodegenerative diseases |
WO2019168953A1 (en) | 2018-02-27 | 2019-09-06 | President And Fellows Of Harvard College | Evolved cas9 variants and uses thereof |
US10507226B1 (en) | 2018-05-02 | 2019-12-17 | University Of South Florida | N-amino peptide beta-sheet mimics for the treatment of Alzheimer's disease |
WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
WO2020023532A1 (en) | 2018-07-23 | 2020-01-30 | Siwa Corporation | Methods and compositions for treating chronic effects of radiation and chemical exposure |
WO2020051360A1 (en) | 2018-09-05 | 2020-03-12 | The Broad Institute, Inc. | Base editing for treating hutchinson-gilford progeria syndrome |
WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
WO2020102659A1 (en) | 2018-11-15 | 2020-05-22 | The Broad Institute, Inc. | G-to-t base editors and uses thereof |
WO2020181193A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through adenosine methylation |
WO2020181195A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through adenine excision |
WO2020181202A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | A:t to t:a base editing through adenine deamination and oxidation |
WO2020181178A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | T:a to a:t base editing through thymine alkylation |
WO2020181180A1 (en) | 2019-03-06 | 2020-09-10 | The Broad Institute, Inc. | A:t to c:g base editors and uses thereof |
WO2020191153A2 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
US11795452B2 (en) | 2019-03-19 | 2023-10-24 | The Broad Institute, Inc. | Methods and compositions for prime editing nucleotide sequences |
WO2020191171A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
US11447770B1 (en) | 2019-03-19 | 2022-09-20 | The Broad Institute, Inc. | Methods and compositions for prime editing nucleotide sequences |
DE112020001342T5 (en) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | Methods and compositions for editing nucleotide sequences |
DE112020001339T5 (en) | 2019-03-19 | 2022-01-13 | President and Fellows of Harvard College | METHOD AND COMPOSITION FOR EDITING NUCLEOTIDE SEQUENCES |
US11643652B2 (en) | 2019-03-19 | 2023-05-09 | The Broad Institute, Inc. | Methods and compositions for prime editing nucleotide sequences |
DE112020001306T5 (en) | 2019-03-19 | 2022-01-27 | Massachusetts Institute Of Technology | METHODS AND COMPOSITIONS FOR EDITING NUCLEOTIDE SEQUENCES |
WO2020210751A1 (en) | 2019-04-12 | 2020-10-15 | The Broad Institute, Inc. | System for genome editing |
WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
WO2020236982A1 (en) | 2019-05-20 | 2020-11-26 | The Broad Institute, Inc. | Aav delivery of nucleobase editors |
WO2021025750A1 (en) | 2019-08-08 | 2021-02-11 | The Broad Institute, Inc. | Base editors with diversified targeting scope |
WO2021030666A1 (en) | 2019-08-15 | 2021-02-18 | The Broad Institute, Inc. | Base editing by transglycosylation |
WO2021050512A1 (en) | 2019-09-09 | 2021-03-18 | Beam Therapeutics Inc. | Novel crispr enzymes, methods, systems and uses thereof |
WO2021072328A1 (en) | 2019-10-10 | 2021-04-15 | The Broad Institute, Inc. | Methods and compositions for prime editing rna |
WO2021108717A2 (en) | 2019-11-26 | 2021-06-03 | The Broad Institute, Inc | Systems and methods for evaluating cas9-independent off-target editing of nucleic acids |
WO2021113494A1 (en) | 2019-12-03 | 2021-06-10 | Beam Therapeutics Inc. | Synthetic guide rna, compositions, methods, and uses thereof |
WO2021155065A1 (en) | 2020-01-28 | 2021-08-05 | The Broad Institute, Inc. | Base editors, compositions, and methods for modifying the mitochondrial genome |
WO2021158921A2 (en) | 2020-02-05 | 2021-08-12 | The Broad Institute, Inc. | Adenine base editors and uses thereof |
WO2021158999A1 (en) | 2020-02-05 | 2021-08-12 | The Broad Institute, Inc. | Gene editing methods for treating spinal muscular atrophy |
WO2021222318A1 (en) | 2020-04-28 | 2021-11-04 | The Broad Institute, Inc. | Targeted base editing of the ush2a gene |
WO2021222758A1 (en) | 2020-05-01 | 2021-11-04 | Siwa Corporation | Methods of treating infections |
US11912985B2 (en) | 2020-05-08 | 2024-02-27 | The Broad Institute, Inc. | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
DE112021002672T5 (en) | 2020-05-08 | 2023-04-13 | President And Fellows Of Harvard College | METHODS AND COMPOSITIONS FOR EDIT BOTH STRANDS SIMULTANEOUSLY OF A DOUBLE STRANDED NUCLEOTIDE TARGET SEQUENCE |
WO2022093195A1 (en) | 2020-10-27 | 2022-05-05 | Siwa Corporation | Methods and compositions for treating osteoarthritis using anti-age antibodies or age antigens |
WO2022094051A2 (en) | 2020-10-28 | 2022-05-05 | Children's Medical Center Corporation | Truncated modified recombinant adamts13 and uses thereof |
WO2022125776A2 (en) | 2020-12-09 | 2022-06-16 | Siwa Corporation | Methods and compositions for treating kidney diseases |
WO2022178307A1 (en) | 2021-02-19 | 2022-08-25 | Beam Therapeutics Inc. | Recombinant rabies viruses for gene therapy |
WO2022204268A2 (en) | 2021-03-23 | 2022-09-29 | Beam Therapeutics Inc. | Novel crispr enzymes, methods, systems and uses thereof |
WO2022221699A1 (en) | 2021-04-16 | 2022-10-20 | Beam Therapeutics, Inc. | Genetic modification of hepatocytes |
WO2022256578A2 (en) | 2021-06-02 | 2022-12-08 | Beam Therapeutics Inc. | Circular guide rnas for crispr/cas editing systems |
WO2022261509A1 (en) | 2021-06-11 | 2022-12-15 | The Broad Institute, Inc. | Improved cytosine to guanine base editors |
WO2023004409A1 (en) | 2021-07-23 | 2023-01-26 | Beam Therapeutics Inc. | Guide rnas for crispr/cas editing systems |
WO2023023654A1 (en) | 2021-08-20 | 2023-02-23 | Siwa Corporation | Methods and compositions for treating fibrotic diseases |
WO2023039468A1 (en) | 2021-09-08 | 2023-03-16 | Beam Therapeutics Inc. | Viral guide rna delivery |
WO2023076898A1 (en) | 2021-10-25 | 2023-05-04 | The Broad Institute, Inc. | Methods and compositions for editing a genome with prime editing and a recombinase |
WO2023081756A1 (en) | 2021-11-03 | 2023-05-11 | The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone | Precise genome editing using retrons |
WO2023094435A1 (en) | 2021-11-23 | 2023-06-01 | Cellectis Sa | New tale protein scaffolds with improved on-target/off-target activity ratios |
WO2023102538A1 (en) | 2021-12-03 | 2023-06-08 | The Broad Institute, Inc. | Self-assembling virus-like particles for delivery of prime editors and methods of making and using same |
WO2023102537A2 (en) | 2021-12-03 | 2023-06-08 | The Broad Institute, Inc. | Self-assembling virus-like particles for delivery of nucleic acid programmable fusion proteins and methods of making and using same |
WO2023114953A2 (en) | 2021-12-17 | 2023-06-22 | Beam Therapeutics Inc. | Novel crispr enzymes, methods, systems and uses thereof |
WO2023196802A1 (en) | 2022-04-04 | 2023-10-12 | The Broad Institute, Inc. | Cas9 variants having non-canonical pam specificities and uses thereof |
WO2023196772A1 (en) | 2022-04-04 | 2023-10-12 | Beam Therapeutics Inc. | Novel rna base editing compositions, systems, methods and uses thereof |
WO2023205687A1 (en) | 2022-04-20 | 2023-10-26 | The Broad Institute, Inc. | Improved prime editing methods and compositions |
WO2023212715A1 (en) | 2022-04-28 | 2023-11-02 | The Broad Institute, Inc. | Aav vectors encoding base editors and uses thereof |
WO2023230613A1 (en) | 2022-05-27 | 2023-11-30 | The Broad Institute, Inc. | Improved mitochondrial base editors and methods for editing mitochondrial dna |
WO2023240137A1 (en) | 2022-06-08 | 2023-12-14 | The Board Institute, Inc. | Evolved cas14a1 variants, compositions, and methods of making and using same in genome editing |
WO2024040083A1 (en) | 2022-08-16 | 2024-02-22 | The Broad Institute, Inc. | Evolved cytosine deaminases and methods of editing dna using same |
WO2024059791A1 (en) | 2022-09-16 | 2024-03-21 | Beam Therapeutics Inc. | Large serine recombinases, systems and uses thereof |
WO2024077267A1 (en) | 2022-10-07 | 2024-04-11 | The Broad Institute, Inc. | Prime editing methods and compositions for treating triplet repeat disorders |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US4917951A (en) | Lipid vesicles formed of surfactants and steroids | |
EP0349579B1 (en) | Lipid vesicles formed of surfactants and steroids | |
CA1289420C (en) | Method of producing high aqueous volume multilamellar vesicles | |
US4911928A (en) | Paucilamellar lipid vesicles | |
US5474848A (en) | Paucilamellar lipid vesicles | |
US5147723A (en) | Paucilamellar lipid vesicles | |
US4687661A (en) | Method for producing liposomes | |
US5628936A (en) | Hybrid paucilamellar lipid vesicles | |
US4853228A (en) | Method of manufacturing unilamellar lipid vesicles | |
AU633631B2 (en) | Paucilamellar lipid vesicles using charge-localized, single chain, nonphospholipid surfactants | |
JPH0753661B2 (en) | Pro-liposome composition and method of making an aqueous dispersion of liposomes | |
US6399094B1 (en) | Unilamellar liposomal preparations with high active substance content | |
Andrieux et al. | Insertion and partition of sodium taurocholate into egg phosphatidylcholine vesicles | |
Paternostre et al. | Liposomes: preparation and membrane protein reconstitution | |
JPH0567605B2 (en) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: MICRO VESICULAR SYSTEMS, INC., 2285 EAST LANDIS AV Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:WALLACH, DONALD F. H.;REEL/FRAME:004814/0464 Effective date: 19871124 |
|
AS | Assignment |
Owner name: FIRST PENNSYLVANIA BANK N.A.. Free format text: SECURITY INTEREST;ASSIGNORS:IGI, INC., A DE CORP.;IGEN, INC., A DE CORP.;IMMUNOGENETICS, INC., A DE CORP.;AND OTHERS;REEL/FRAME:004845/0707 Effective date: 19880210 |
|
AS | Assignment |
Owner name: MICRO-PAK, INC., 103 SPRINGER BUILDING, 3411 SILVE Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:MICRO VESICULAR SYSTEMS, INC.,;REEL/FRAME:004931/0136 Effective date: 19880803 Owner name: MICRO-PAK, INC., 103 SPRINGER BUILDING,DELAWARE Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MICRO VESICULAR SYSTEMS, INC.,;REEL/FRAME:004931/0136 Effective date: 19880803 |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
FPAY | Fee payment |
Year of fee payment: 4 |
|
FPAY | Fee payment |
Year of fee payment: 8 |
|
AS | Assignment |
Owner name: FLEET CAPITAL CORPORATION, CONNECTICUT Free format text: SECURITY INTEREST;ASSIGNOR:IGEN, INC;REEL/FRAME:010639/0483 Effective date: 19991029 |
|
FPAY | Fee payment |
Year of fee payment: 12 |
|
AS | Assignment |
Owner name: NOVAVAX, INC., MARYLAND Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:MICRO-PAK, INC.;REEL/FRAME:013036/0600 Effective date: 20020618 |
|
AS | Assignment |
Owner name: IGEN, INC., NEW JERSEY Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:FLEET CAPITAL CORPORATION;REEL/FRAME:022248/0477 Effective date: 20020531 |