US4112773A - Ultrasonic particulate sensing - Google Patents

Ultrasonic particulate sensing Download PDF

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Publication number
US4112773A
US4112773A US05/792,669 US79266977A US4112773A US 4112773 A US4112773 A US 4112773A US 79266977 A US79266977 A US 79266977A US 4112773 A US4112773 A US 4112773A
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United States
Prior art keywords
conduit
transmitter
receiver surface
hole
focal point
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Expired - Lifetime
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US05/792,669
Inventor
Leigh Roy Abts
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MONITEK TECHNOLOGIES Inc
MONITEK TECHNOLOGIES Inc A CORP OF
Rhode Island Hospital
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Rhode Island Hospital
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Priority to US05/792,669 priority Critical patent/US4112773A/en
Priority to CA000302242A priority patent/CA1121502A/en
Application granted granted Critical
Publication of US4112773A publication Critical patent/US4112773A/en
Assigned to MICRO PURE SYSTEMS, INC. reassignment MICRO PURE SYSTEMS, INC. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: OLD STONE BANK
Assigned to MONITEK TECHNOLOGIES, INC., A CORP. OF DE reassignment MONITEK TECHNOLOGIES, INC., A CORP. OF DE ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: MICRO PURE SYSTEMS, INC.
Assigned to MONITEK TECHNOLOGIES, INC. reassignment MONITEK TECHNOLOGIES, INC. ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: MICRO PURE SYSTEMS, INC.
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    • GPHYSICS
    • G10MUSICAL INSTRUMENTS; ACOUSTICS
    • G10KSOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
    • G10K11/00Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
    • G10K11/18Methods or devices for transmitting, conducting or directing sound
    • G10K11/26Sound-focusing or directing, e.g. scanning
    • G10K11/32Sound-focusing or directing, e.g. scanning characterised by the shape of the source
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/02Analysing fluids
    • G01N29/032Analysing fluids by measuring attenuation of acoustic waves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3626Gas bubble detectors

Definitions

  • This invention relates to obtaining information about matter discontinuities in flowing fluid streams.
  • this invention relates to determining such things as the number and size of such discontinuities, for example microembolisms in blood flowing in a conduit.
  • Pulse-echo ultrasonic search units are well known, particularly in nondestructive testing systems; bursts or pulses emitted by such units are detected when reflected back from discontinuities, such as inclusions, as disclosed in Automation Industries' McElroy U.S. Pat. No. 3,821,834, "Method of Making an Ultrasonic Search Unit", granted July 2, 1974. Pulse-echo ultrasonic search units have also been used to measure particles in liquid, as taught in the same company's McGaughey et al. U.S. Pat. No. 3,269,172, "Apparatus for Measuring Particles in Liquids", granted Aug. 30, 1966.
  • a concave transmitting surface arranged to transmit generally across a conduit, with a focal length of not over twice the distance across the conduit.
  • a search unit working with a pulse transmitting surface continuous with a surface of the conduit directs transmission across the conduit.
  • a flat-surfaced piezoelectric transmitter is coupled with a concave cylindrical lens, integral with the rest of the wall of a cylindrical conduit, to provide the transmitting surface, and the focal length is less than the diameter of the conduit.
  • the invention is especially useful in evaluating very small particles or other discontinuities (e.g., bubbles in liquid) present in very small quantity. It has advantages of sensitivity, high field density, simplicity, and relative freedom from eddies and other turbulence.
  • FIG. 1 is an isometric view of the most preferred embodiment of the invention, with one of its crystals, and associated wire and potting, omitted.
  • FIG. 2 is an enlarged sectional view therethrough, at 2--2.
  • FIG. 3 is a three-dimensional view of another embodiment of the invention.
  • FIGS. 1 and 2 there is shown a transparent methyl methacrylate blood-conducting unit 10 with end portions 12, 14 to cooperate with tubing.
  • a polished cylindrical blood passage 16, 1/2 inches in diameter and 41/2inches in length, is defined by wall 18 and the end portions.
  • Integral with wall 18 are two lenses 20 with cylindrically concave inner surfaces 22 (chosen to focus the field of sound F on a line inside passage 16 near the opposite wall 18 thereof) and planar upper surfaces 24.
  • the latter are provided by a pair of blind grooves 26 cut into wall 18 to extend along centerlines longitudinally and radially thereof, said centerlines being along radii of the unit 10 displaced 90° from each other.
  • the minimum lens thickness, defined by the separation between surfaces 22 and 24 along said centerlines, is 0.010 inch.
  • each groove 26 Surrounding each groove 26 are three closely spaced rows of blind holes 36. These holes are 1 mm. in diameter, extend generally parallel to the walls of grooves 26, and do not extend into passage 16.
  • the crystals may suitably be formed from round ceramic crystals sold by Keramos, Incorporated, 104 N. Church St., Lizton, Ind., under the trade designation K 81. These are preferably electrically connected in a pulser-receiver unit mounted in a reflectoscope sold by the aforementioned Automation Industries, of Shelter Rock Road, Danbury, Conn. (Model UM 771-B).
  • FIG. 3 is shown a half annulus of methyl methacrylate; it is provided with one blind groove, a crystal, a lens, and a multiplicity of blind holes, all just as in the embodiment of FIGS. 1 and 2.
  • each crystal may as desired be energized to give a 5 megahertz output for two microseconds, to transmit through its associated lens an ultrasonic pulse of that duration. Any reflection received may be displayed on an oscilloscope portion of the reflectoscope.
  • the shapes of the curves generated provide information about discontinuities in blood flowing through the passage. Thus number of peaks reflects number of particles and increased amplitude reflects increased particle size, particularly in situations in which only one particle is ordinarily within the field of focus (shaded, at F) at any given time.
  • the reflectoscope oscilloscope permits visual observation giving useful information. Provision of the two pulse echo stations 90° apart facilitates determining further the shape of a particular particle. Holes 36 damp acoustic impulses passing in directions toward them.
  • FIG. 3 is used in much the same way, except that in it the transmitting surface is not a part of the fluid conduit wall.
  • This unit may be placed alongside (e.g.) a blood vessel to detect discontinuities flowing therein.
  • the passage wall and lens may be made of material transparent to ultrasound but not to light.
  • the crystal itself may be formed with a concave transmitting surface. Signal output may be taken to a computer programmed to print out information.

Abstract

A pulse echo device with a concave transmitter-receiver surface located to direct ultrasonic energy to a focal point spaced therefrom transversely of a conduit, the focal point being a distance transversely of the conduit less than twice the thickness of the conduit.

Description

This invention relates to obtaining information about matter discontinuities in flowing fluid streams.
FIELD OF THE INVENTION
In particular, this invention relates to determining such things as the number and size of such discontinuities, for example microembolisms in blood flowing in a conduit.
BACKGROUND OF THE INVENTION
Pulse-echo ultrasonic search units are well known, particularly in nondestructive testing systems; bursts or pulses emitted by such units are detected when reflected back from discontinuities, such as inclusions, as disclosed in Automation Industries' McElroy U.S. Pat. No. 3,821,834, "Method of Making an Ultrasonic Search Unit", granted July 2, 1974. Pulse-echo ultrasonic search units have also been used to measure particles in liquid, as taught in the same company's McGaughey et al. U.S. Pat. No. 3,269,172, "Apparatus for Measuring Particles in Liquids", granted Aug. 30, 1966. A generally similar approach was used to measure discontinuities in blood flowing in a conduit by Patterson et al. ("Microemboli during cardiopulmonary bypass detected by ultrasound", Surg., Gyn. & Obs., 129: 505-510, 1969) and by Szabo et al. ("Arterial blood filter evaluation by echo-ultrasound", Proc. 27th Annual Conference on Engineering in Medicine and Biology, 160: 191, 1974). McGaughey, Patterson et al., and Szabo et al. each of them directed the transmitted signal coaxially longitudinally of the conduit, with a focal point many times the diameter of the conduit in distance from the search unit's transmitting surface. Furthermore, they used flat or convex transmitting surfaces.
SUMMARY OF THE INVENTION
I have discovered that discontinuities in fluid flowing in a conduit can be detected with greatly improved sensitivity, yet with great simplicity, by providing in a pulse echo device a concave transmitting surface arranged to transmit generally across a conduit, with a focal length of not over twice the distance across the conduit. In preferred embodiments a search unit working with a pulse transmitting surface continuous with a surface of the conduit directs transmission across the conduit. In the most preferred embodiment, a flat-surfaced piezoelectric transmitter is coupled with a concave cylindrical lens, integral with the rest of the wall of a cylindrical conduit, to provide the transmitting surface, and the focal length is less than the diameter of the conduit.
The invention is especially useful in evaluating very small particles or other discontinuities (e.g., bubbles in liquid) present in very small quantity. It has advantages of sensitivity, high field density, simplicity, and relative freedom from eddies and other turbulence.
DESCRIPTION OF PREFERRED EMBODIMENTS
The structure and operation of preferred embodiments of the invention are as follows.
Structure
The drawings shown the preferred embodiments, then described.
DRAWINGS
FIG. 1 is an isometric view of the most preferred embodiment of the invention, with one of its crystals, and associated wire and potting, omitted.
FIG. 2 is an enlarged sectional view therethrough, at 2--2.
FIG. 3 is a three-dimensional view of another embodiment of the invention.
DESCRIPTION
Turning now to FIGS. 1 and 2, there is shown a transparent methyl methacrylate blood-conducting unit 10 with end portions 12, 14 to cooperate with tubing. A polished cylindrical blood passage 16, 1/2 inches in diameter and 41/2inches in length, is defined by wall 18 and the end portions. Integral with wall 18 are two lenses 20 with cylindrically concave inner surfaces 22 (chosen to focus the field of sound F on a line inside passage 16 near the opposite wall 18 thereof) and planar upper surfaces 24. The latter are provided by a pair of blind grooves 26 cut into wall 18 to extend along centerlines longitudinally and radially thereof, said centerlines being along radii of the unit 10 displaced 90° from each other. The minimum lens thickness, defined by the separation between surfaces 22 and 24 along said centerlines, is 0.010 inch.
Seated in grooves 26 are ceramic piezoelectric crystals 28 and 30, acoustically coupled to lenses 20 and electrically connected as is conventional with, e.g., wire 32.
Surrounding each groove 26 are three closely spaced rows of blind holes 36. These holes are 1 mm. in diameter, extend generally parallel to the walls of grooves 26, and do not extend into passage 16.
The crystals may suitably be formed from round ceramic crystals sold by Keramos, Incorporated, 104 N. Church St., Lizton, Ind., under the trade designation K 81. These are preferably electrically connected in a pulser-receiver unit mounted in a reflectoscope sold by the aforementioned Automation Industries, of Shelter Rock Road, Danbury, Conn. (Model UM 771-B).
In FIG. 3 is shown a half annulus of methyl methacrylate; it is provided with one blind groove, a crystal, a lens, and a multiplicity of blind holes, all just as in the embodiment of FIGS. 1 and 2.
Operation
In operation, each crystal may as desired be energized to give a 5 megahertz output for two microseconds, to transmit through its associated lens an ultrasonic pulse of that duration. Any reflection received may be displayed on an oscilloscope portion of the reflectoscope. The shapes of the curves generated provide information about discontinuities in blood flowing through the passage. Thus number of peaks reflects number of particles and increased amplitude reflects increased particle size, particularly in situations in which only one particle is ordinarily within the field of focus (shaded, at F) at any given time. The reflectoscope oscilloscope permits visual observation giving useful information. Provision of the two pulse echo stations 90° apart facilitates determining further the shape of a particular particle. Holes 36 damp acoustic impulses passing in directions toward them.
The embodiment of FIG. 3 is used in much the same way, except that in it the transmitting surface is not a part of the fluid conduit wall. This unit may be placed alongside (e.g.) a blood vessel to detect discontinuities flowing therein.
OTHER EMBODIMENTS
The passage wall and lens may be made of material transparent to ultrasound but not to light. The crystal itself may be formed with a concave transmitting surface. Signal output may be taken to a computer programmed to print out information.

Claims (8)

What is claimed is:
1. A pulse echo device comprising
a conduit,
said conduit including a blind hole and
an inwardly concave transmitter-receiver surface, and
an acoustical transducer mounted in said blind hole for delivering ultrasonic energy through said transmitter-receiver surface,
said transmitter-receiver surface being located to serve as a lens for and to thereby focus said ultrasonic energy to a focal point at a distance transversely of said conduit, in a direction from said transmitter-receiver surface toward said focal point, of not more than twice the distance in said direction across said conduit.
2. The device of claim 1 in which the bottom of said blind hole is flat.
3. The device of claim 1 in which said conduit is cylindrical.
4. The device of claim 3 in which said focal length is slightly less than the diameter of said conduit.
5. The device of claim 2 in which said hole is an elongated groove.
6. The device of claim 5 in which said wall is of methyl methacrylate.
7. The device of claim 2 in which said hole is surrounded by a multiplicity of closely-spaced small blind holes.
8. The device of claim 7 in which said small blind holes define a plurality of rows.
US05/792,669 1977-05-02 1977-05-02 Ultrasonic particulate sensing Expired - Lifetime US4112773A (en)

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US05/792,669 US4112773A (en) 1977-05-02 1977-05-02 Ultrasonic particulate sensing
CA000302242A CA1121502A (en) 1977-05-02 1978-04-28 Ultrasonic particulate sensing

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US05/792,669 US4112773A (en) 1977-05-02 1977-05-02 Ultrasonic particulate sensing

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US05/931,478 Continuation US4237720A (en) 1978-08-07 1978-08-07 Ultrasonic particulate sensing

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Cited By (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4214484A (en) * 1978-10-16 1980-07-29 Rhode Island Hospital Ultrasonic particulate sensing
US4217781A (en) * 1979-04-18 1980-08-19 Micro Pure Systems, Inc. Ultrasonic particulate sensing
FR2483080A1 (en) * 1980-05-21 1981-11-27 Micro Pure Systems Inc METHOD AND DEVICE FOR IDENTIFYING DISCONTINUITIES IN A FLOW
US4319580A (en) * 1979-08-28 1982-03-16 The Board Of Regents Of The University Of Washington Method for detecting air emboli in the blood in an intracorporeal blood vessel
EP0050040A2 (en) * 1980-10-14 1982-04-21 Purdue Research Foundation A method and apparatus for the detection of impurities in a liquid such as blood
US4354501A (en) * 1979-08-28 1982-10-19 Univ Washington Esophageal catheter including ultrasonic transducer for use in detection of air emboli
US4354500A (en) * 1979-08-28 1982-10-19 Univ Washington System using ultrasonic energy for detection and quantification of air emboli
US4354502A (en) * 1979-08-28 1982-10-19 The Board Of Regents Of The University Of Washington Intravascular catheter including untrasonic transducer for use in detection and aspiration of air emboli
US4365515A (en) * 1980-09-15 1982-12-28 Micro Pure Systems, Inc. Ultrasonic sensing
US4381674A (en) * 1981-06-22 1983-05-03 Micro Pure Systems, Inc. Ultrasonic detecting and identifying of particulates
US4398424A (en) * 1980-12-16 1983-08-16 Micro Pure Systems, Inc. Ultrasonic sensing
US4448062A (en) * 1981-10-22 1984-05-15 Conoco Inc. Method and apparatus for erosion detection and location in hydrocarbon production systems and the like
US4527420A (en) * 1982-06-11 1985-07-09 Micro Pure Systems, Inc. Ultrasonic particulate sensing
US4580444A (en) * 1984-02-10 1986-04-08 Micro Pure Systems, Inc. Ultrasonic determination of component concentrations in multi-component fluids
US4608507A (en) * 1984-06-29 1986-08-26 Micro Pure Systems, Inc. Damping device for focused piezoelectric transducer
US4665925A (en) * 1985-09-13 1987-05-19 Pfizer Hospital Products Group, Inc. Doppler catheter
US4739662A (en) * 1982-06-11 1988-04-26 Micro Pure Systems, Inc. Ultrasonic particulate sensing
US4771788A (en) * 1986-07-18 1988-09-20 Pfizer Hospital Products Group, Inc. Doppler tip wire guide
US4787240A (en) * 1987-08-31 1988-11-29 Westinghouse Electric Corp. Liquid measurement arrangement
US4821558A (en) * 1987-05-01 1989-04-18 Abbott Laboratories Ultrasonic detector
US4889128A (en) * 1985-09-13 1989-12-26 Pfizer Hospital Products Doppler catheter
US5000663A (en) * 1989-09-05 1991-03-19 Pacesetter Infusion, Ltd. Automatic tubing lock for ultrasonic sensor interface
US5043706A (en) * 1990-10-19 1991-08-27 Eastman Kodak Company System and method for detecting bubbles in a flowing fluid
US5053747A (en) * 1989-09-05 1991-10-01 Pacesetter Infusion, Inc. Ultrasonic air-in-line detector self-test technique
US5064412A (en) * 1989-09-05 1991-11-12 Pacesetter Infusion, Ltd. Ultrasonic air-in-line detector for a medication infusion system
US5126616A (en) * 1989-09-05 1992-06-30 Pacesetter Infusion, Ltd. Ultrasonic transducer electrical interface assembly
US5176631A (en) * 1989-09-05 1993-01-05 Pacesetter Infusion, Ltd. Ultrasonic air-in-line detector for detecting entrained air in a medication infusion system
US5177993A (en) * 1991-07-22 1993-01-12 Ivac Corporation Air-in-line sensor
WO1993015397A1 (en) * 1992-01-23 1993-08-05 Cobe Laboratories, Inc. Method and apparatus for detection of air bubbles in tubing
US5394732A (en) * 1993-09-10 1995-03-07 Cobe Laboratories, Inc. Method and apparatus for ultrasonic detection of air bubbles
US6467331B1 (en) * 2000-02-04 2002-10-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Bubble measuring instrument and method
US20060178581A1 (en) * 2004-11-15 2006-08-10 Africk Steven A System and method for ultrasonic measuring of particle properties
US20070000329A1 (en) * 2005-06-29 2007-01-04 Battelle Energy Alliance, Llc Ultrasonic transducer
US20070045188A1 (en) * 2005-08-26 2007-03-01 Ceeben Systems, Inc. Ultrasonic Material Removal System for Cardiopulmonary Bypass and Other Applications
US8033157B2 (en) 2007-10-01 2011-10-11 Baxter International Inc. Medical fluid air bubble detection apparatus and method
US20180369564A1 (en) * 2017-06-21 2018-12-27 Kristin Rossodivito System and method for detecting air embolisms in lines for hemodynamic monitoring

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3204458A (en) * 1962-07-02 1965-09-07 Gulton Ind Inc Ultrasonic flowmeter
US3898637A (en) * 1973-07-27 1975-08-05 Eugene B Wolstenholme Detection means for gas entering human blood system from extra-corporeal tubing
US3974681A (en) * 1973-10-23 1976-08-17 Jerry Namery Ultrasonic bubble detector

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3204458A (en) * 1962-07-02 1965-09-07 Gulton Ind Inc Ultrasonic flowmeter
US3898637A (en) * 1973-07-27 1975-08-05 Eugene B Wolstenholme Detection means for gas entering human blood system from extra-corporeal tubing
US3974681A (en) * 1973-10-23 1976-08-17 Jerry Namery Ultrasonic bubble detector

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4214484A (en) * 1978-10-16 1980-07-29 Rhode Island Hospital Ultrasonic particulate sensing
US4217781A (en) * 1979-04-18 1980-08-19 Micro Pure Systems, Inc. Ultrasonic particulate sensing
US4354502A (en) * 1979-08-28 1982-10-19 The Board Of Regents Of The University Of Washington Intravascular catheter including untrasonic transducer for use in detection and aspiration of air emboli
US4319580A (en) * 1979-08-28 1982-03-16 The Board Of Regents Of The University Of Washington Method for detecting air emboli in the blood in an intracorporeal blood vessel
US4354501A (en) * 1979-08-28 1982-10-19 Univ Washington Esophageal catheter including ultrasonic transducer for use in detection of air emboli
US4354500A (en) * 1979-08-28 1982-10-19 Univ Washington System using ultrasonic energy for detection and quantification of air emboli
FR2483080A1 (en) * 1980-05-21 1981-11-27 Micro Pure Systems Inc METHOD AND DEVICE FOR IDENTIFYING DISCONTINUITIES IN A FLOW
US4365515A (en) * 1980-09-15 1982-12-28 Micro Pure Systems, Inc. Ultrasonic sensing
EP0050040A2 (en) * 1980-10-14 1982-04-21 Purdue Research Foundation A method and apparatus for the detection of impurities in a liquid such as blood
EP0050040A3 (en) * 1980-10-14 1982-05-12 Purdue Research Foundation A method and apparatus for the detection of impurities in a liquid such as blood
US4398424A (en) * 1980-12-16 1983-08-16 Micro Pure Systems, Inc. Ultrasonic sensing
US4381674A (en) * 1981-06-22 1983-05-03 Micro Pure Systems, Inc. Ultrasonic detecting and identifying of particulates
US4448062A (en) * 1981-10-22 1984-05-15 Conoco Inc. Method and apparatus for erosion detection and location in hydrocarbon production systems and the like
US4527420A (en) * 1982-06-11 1985-07-09 Micro Pure Systems, Inc. Ultrasonic particulate sensing
FR2561393A1 (en) * 1982-06-11 1985-09-20 Micro Pure Systems Inc ULTRASONIC MACROPARTICLE SENSOR
US4739662A (en) * 1982-06-11 1988-04-26 Micro Pure Systems, Inc. Ultrasonic particulate sensing
US4580444A (en) * 1984-02-10 1986-04-08 Micro Pure Systems, Inc. Ultrasonic determination of component concentrations in multi-component fluids
US4608507A (en) * 1984-06-29 1986-08-26 Micro Pure Systems, Inc. Damping device for focused piezoelectric transducer
US4889128A (en) * 1985-09-13 1989-12-26 Pfizer Hospital Products Doppler catheter
US4665925A (en) * 1985-09-13 1987-05-19 Pfizer Hospital Products Group, Inc. Doppler catheter
US4771788A (en) * 1986-07-18 1988-09-20 Pfizer Hospital Products Group, Inc. Doppler tip wire guide
US4821558A (en) * 1987-05-01 1989-04-18 Abbott Laboratories Ultrasonic detector
US4944191A (en) * 1987-05-01 1990-07-31 Abbott Laboratories Ultrasonic detector
US4787240A (en) * 1987-08-31 1988-11-29 Westinghouse Electric Corp. Liquid measurement arrangement
US5126616A (en) * 1989-09-05 1992-06-30 Pacesetter Infusion, Ltd. Ultrasonic transducer electrical interface assembly
US5053747A (en) * 1989-09-05 1991-10-01 Pacesetter Infusion, Inc. Ultrasonic air-in-line detector self-test technique
US5064412A (en) * 1989-09-05 1991-11-12 Pacesetter Infusion, Ltd. Ultrasonic air-in-line detector for a medication infusion system
US5000663A (en) * 1989-09-05 1991-03-19 Pacesetter Infusion, Ltd. Automatic tubing lock for ultrasonic sensor interface
US5176631A (en) * 1989-09-05 1993-01-05 Pacesetter Infusion, Ltd. Ultrasonic air-in-line detector for detecting entrained air in a medication infusion system
US5043706A (en) * 1990-10-19 1991-08-27 Eastman Kodak Company System and method for detecting bubbles in a flowing fluid
US5177993A (en) * 1991-07-22 1993-01-12 Ivac Corporation Air-in-line sensor
WO1993015397A1 (en) * 1992-01-23 1993-08-05 Cobe Laboratories, Inc. Method and apparatus for detection of air bubbles in tubing
EP0577812A1 (en) * 1992-01-23 1994-01-12 Cobe Laboratories, Inc. Method and apparatus for detection of air bubbles in tubing
US5394732A (en) * 1993-09-10 1995-03-07 Cobe Laboratories, Inc. Method and apparatus for ultrasonic detection of air bubbles
US6467331B1 (en) * 2000-02-04 2002-10-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Bubble measuring instrument and method
US7984642B2 (en) * 2004-11-15 2011-07-26 Massachusetts Institute Of Technology System and method for ultrasonic measuring of particle properties
US7543480B2 (en) 2004-11-15 2009-06-09 Massachusetts Institute Of Technology System and method for ultrasonic measuring of particle properties
US20100031735A1 (en) * 2004-11-15 2010-02-11 Africk Steve A System and method for ultrasonic measuring of particle properties
US20060178581A1 (en) * 2004-11-15 2006-08-10 Africk Steven A System and method for ultrasonic measuring of particle properties
US20070000329A1 (en) * 2005-06-29 2007-01-04 Battelle Energy Alliance, Llc Ultrasonic transducer
US7188526B2 (en) 2005-06-29 2007-03-13 Battelle Energy Alliance, Llc Ultrasonic transducer
US20070045188A1 (en) * 2005-08-26 2007-03-01 Ceeben Systems, Inc. Ultrasonic Material Removal System for Cardiopulmonary Bypass and Other Applications
US7699799B2 (en) * 2005-08-26 2010-04-20 Ceeben Systems, Inc. Ultrasonic material removal system for cardiopulmonary bypass and other applications
US20100160846A1 (en) * 2005-08-26 2010-06-24 Ceeben Systems, Inc. Ultrasonic Material Removal System For Cardiopulmonary Bypass and Other Applications
US8033157B2 (en) 2007-10-01 2011-10-11 Baxter International Inc. Medical fluid air bubble detection apparatus and method
US20180369564A1 (en) * 2017-06-21 2018-12-27 Kristin Rossodivito System and method for detecting air embolisms in lines for hemodynamic monitoring
US11517734B2 (en) * 2017-06-21 2022-12-06 Kristin Rossodivito System and method for detecting air embolisms in lines for hemodynamic monitoring

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