|Publication number||US3924641 A|
|Publication date||9 Dec 1975|
|Filing date||19 Aug 1974|
|Priority date||19 Aug 1974|
|Publication number||US 3924641 A, US 3924641A, US-A-3924641, US3924641 A, US3924641A|
|Inventors||Gerhard T Weiss|
|Original Assignee||Axotronics Inc|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (5), Referenced by (82), Classifications (11), Legal Events (2)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent 1191 Weiss Dec. 9, 1975 Bl-PHASIC CURRENT STIMULATION Primary ExaminerRichard A. Gaudet SYSTEM Assistant ExaminerLee S. Cohen  Inventor; Gerhard Weiss, Northford Conn. Attorney, Agent, or Firm-Walter Spruegel  Assignee: Axotronics lnc., Hamden, Conn.
 ABSTRACT  Filed: Aug. 19, 1974 A circuit for producing current-controlled bi-phasic  PP No: 498,740 pulses to stimulate living tissue includes two conducting paths connected in parallel between high and low 52 US. Cl 128/419 PG; 128/421 W terminals with each of the csnducting PathS 51 1m. (:1. A61N l/36 havmg first and seem! switches in Series 5 Field f Search 128/42O, 421, 422 423, therein. The intersections of the respective first and 128/419 13, 419 C 419 E 419 G, 419 PG, second switches in each of the paths define output ter- 9 R minals across which bi-phasic pulses are produced. These output terminals include electrode members for 5 References Cited electrically attaching therlrli tto living tissutes. lrgerfcolrlinectin circuits connectt e irst switch 0 eac 0 t e UNITED STATES PATENTS condu ting paths with the second switch of the other LaVCZZT) conducting to respectively open and close the 2 a 419 P6 second switches in response to the first switches of op- 3:727:616 41973 1.5112122: izizi i i: posite paths being operfed and closed A digital 3,835,865 9/1974 Bowers 128/419 PG gramme alternately dm'es one of the first swltches Canada 128/419 R open and the other closed. Current controlling valves are connected in the paths between the low voltage terminal and the output terminals to selectively control current flow through the electrodes.
7 Claims, 2 Drawing Figures US. Patent Dec. 9, 1975 & mama VQZMGE /-4 BI-PHASIC CURRENT STIMULATION SYSTEM BACKGROUND OF THE INVENTION This invention relates broadly to the art of electronic stimulators and more particularly to devices for generating current controlled, bi-phasic pulses to stimulate areas of the brain, nerves, or other organs.
In behavioral research, stimulation of certain areas of the brain is often used to find ways to suppress intractable pain, aggressive behavior, or toexplore brain structures and their influence on the behavior of animals or humans. Brain stimulation is also applied in efforts to fight other disorders associated with the brain.
In addition to brain research, electrical stimulation is also widely used to restore proper functioning of various organs such as hearts, lungs, or bladders in cases where the control of these organs is disturbed because of disease, injury, or other causes.
The effects elicited by electrical stimulations are, to a large extent, determined by the amounts of current flow rather than by the magnitudes of applied voltages. Since the impedance between points of stimulation varies widely and may even change during stimulation, the current will also change even if the voltage is maintained at a constant level. This makes it difficult to control the amount of current flow. Thus, it is an object of this invention to provide an electrical stimulation circuit which provides an adjustable, controllable, stimulating current.
Further, if pulses of one polarity only are used for stimulation, electro/chemical effects tend to create unfavorable interactions between electrodes and tissues. Many researchers, therefore, prefer stimulation pulses in both polarities, such as with a negative pulse, followed immediately by a positive pulse, preferably each being of equal magnitude and duration. Thus, it is an object of this invention to provide an electrical circuit for providing such pulses.
Another object of this invention is to provide a circuit for generating bi-phasic, current-controlled pulses with current amplitudes of both negative and positive portions thereof being proportional to an applied control voltage.
Still another object of this invention is to provide a current controlled, bi-phasic or mono-phasic pulse generator whose output impedance is high enough to allow the use of its stimulation electrodes for measuring the response to stimulation, e.g. brain stimulation, EEG recordings and the like.
Still another object of this invention is to provide a circuit for generating bi-phasic or mono-phasic current controlled pulses, the characteristics of which are controlled by a programmer.
SUMMARY OF THE INVENTION first switch of the first path is interconnected to the second switch of the second path, and vice versa, to assure that the first and second switches of opposite paths are opened and closed together. A driving device alternately drives the first switch of the first path on or closed," and the first switch of the second path off,
2 or open, and vice versa. The driving mechanism measures the time period that the switches are in open and closed positions, Electronic valves are located in each of the first and second paths between the first voltage terminal and the output terminals to selectively control current flow to the electrodes.
BRIEF DESCRIPTION OF THE DRAWINGS The foregoing and other objects, features and advantages of the invention will be apparent from the following more particular description of a preferred embodiment of the invention, as illustrated in the accompanying drawings in which reference characters refer to the same parts throughout the different views. The drawings are not necessarily to scale, emphasis instead being placed upon illustrating principles of the invention in a clear manner.
FIG. 1 is a schematic diagram of a current controlled, bi-phasis pulse generator employing principles of this invention; and
FIG. 2 is a diagrammatic representation of an output pulse of the bi-phasic pulse generator of FIG. 1.
DESCRIPTION OF THE PREFERRED EMBODIMENT The preferred embodiment of the pulse generator of this invention, illustrated in FIG. 1, comprises two first transistor switches 10 and 12, two second transistor switches 14 'and 16, a pair of current control valve devices 18 and 20, a digital programmer 22 and a control voltage generator 24. The pulse generator is energized by a +20 volts, positive voltage terminal 26 and a -20 volts, negative voltage terminal 28 and forms two parallel connected, main conducting paths 30 and 32 between these voltage terminals. In practice, a single 40 volt source could be used.
The first transistor switches 10 and 12 comprise PNP transistors Q1 and Q2 and 22K control resistors 34 and 36. The second transistor switches 14 and 16 comprise NPN transistors Q3 and Q4 and K control resistors 38 and 40, In this regard, the interconnection between the positive voltage terminal 26 and the base of the transistor Q1 via the resistor 34 holds transistor O1 in an off state when transistor Q4 is off and no current can flow through resistor 40. When transistor O4 is on, a current path is established from the positive voltage terminal 26 through both the Q1 base-to-emitter junction, and the resistor 34, the resistor 40, and the transistor O4 to the negative voltage terminal 28, thereby placing transistor O1 in an on state. There is a similar interaction between the resistors 36 and 38 and the transistors Q2 and Q3.
The first and second current control valve devices 18 and 20 respectively comprise NPN transistors Q5 and Q6 and series resistors 42 and 44.
In the preferred embodiment, the switching transistors Q1, Q2, Q3, and Q4 are chosen to operate, for practical purposes, in an on-off fashion while the current control transistors Q5 and Q6 are chosen to operate in a gradual manner for regulating current flow.
Electrodes 46 and 48, which are adapted to be electricallyattached to living tissue, are respectively electrically connected to the main conducting paths 30 and 32 between the transistor switch 10- and the first current control valve device 18 and between'the transistor switch 12 and thesecond current control valve device The digital programmer 22 is connected to the bases of the switching transistors Q3 and Q4 and selectively provides gating signals to these transistors. The digital programmer 22 also drives the control voltage generator 24 which, in turn, selectively produces steady-state control voltages at the bases of the first and second current control transistors Q and Q6.
Diodes 50 and 52 prevent excess reverse voltages from occurring between the bases and emitters of the current control transistors Q5 and Q6.
In operation, the electrodes 46 and 48 are connected to living tissue, such as nerves or other organs, either directly or indirectly. When it is desired to transmit biphasic pulses to the living tissue, the digital programmer 22 gates the switching transistor Q3 on and the switching transistor Q4 off for a time period of T1 and then gates the switching transistor Q4 on and switching transistor Q3 off for an identical time period T2.
During time period Tl, when the switching transistor Q3 is on, a current flow is established through the control resistors 36 and 38 to lower the potential appearing at the base of the switching transistor Q2. This places the switching transistor Q2 in an on mode of operation. Thus, a circuit is established between the positive voltage terminal 26 and the first electrode 46 through the switching transistor Q2. A circuit is also completed between the second electrode 48 and the negative voltage terminal 28 via the current control transistor Q5, the resistor 42, and diode 50, and the switching transistor Q3. Thus, a circuit is completed from the positive voltage terminal 26 to the negative voltage terminal 28 via living tissue connected to the electrodes 46 and 48. It should be noted that during time period T, both of the switching transistors Q4 and Q1 are locked in off modes.
During the time period T2 the switching transistor Q3 is turned off so that the voltage appearing at the base of the switching transistor Q2 rises to the voltage of the positive voltage terminal 26, which, in turn, turns off the switching transistor Q2. Thus, the electrode 46 is no longer connected to the high voltage terminal 26. However, the switching transistor Q4 is turned on by the digital programmer 22 so that the voltage at the base of the switching transistor Q1 rises to turn on this transistor. Thus, the electrode 48 is now in communication with the positive voltage terminal 26. Also, the other electrode 46 is now in communication with the negative voltage terminal 28 via the second current control device 20, the diode 52 and the switching transistor Q4. Thus, the polarities, and current flow, of the electrodes 46 and 48 have been reversed.
Before and after the time periods T1 and T2, the digital programmer does not place either the third or fourth switching transistors Q3 and Q4 in on modes of operation so that neither of the electrodes 46 and 48 are connected to the positive and negative voltage terminals 26 and 28. The output signal appearing at electrodes 46 and 48 before, after, and during the time periods T1 and T2 can be graphically represented as shown in FIG. 2.
In the preferred embodiment, the control voltage generator 24 provides steady-state control voltages ranging from 1.4 to 5 volts. It should be understood that the magnitude of a selected control voltage determines the magnitudes of current signals applied by the electrodes 46 and 48 to living tissue.
It should be further appreciated that the duration of the pulses can be accurately controlled by the digital programmer 22.
In addition, during periods of no pulses, since all four transistor switches are open, the electrodes 46 and 48 can be used for recording purposes.
While the invention has been particularly shown and described with reference to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and detail may be made therein without departing from the spirit and scope of the invention. For example, various voltage magnitudes at voltage terminals 26 and 28 could be employed and it is not necessary that one of the supply voltages be either negative or positive. With regard to voltage magni tude, the high voltage source limit is determined by the perimeters of the transistors chosen and/or by the maximum current which has to be driven through the highest expected load impedance. Further, the transistors could be replaced by other types of electrical valves.
The embodiment of the invention in which an exclusive property or privilege are claimed are defined as follows:
1. A bi-phasic pulse generator for producing pulses to stimulate living tissue comprising:
first and second voltage terminals having voltages of different magnitudes;
first and second conducting paths connected in parallel between said first and second voltage terminals, each of said first and second conducting paths including first and second switches connected in series, with said first switch being connected electrically closer to said first voltage terminal than said second switch and the intersections of said first and second switches in each of said paths defining output electrodes across which pulse-generator output bi-phasic pulses are produced;
interconnecting means for connecting said first switch of said first conducting path with said second switch of said second conducting path and said first switch of said second conducting path with said second switch of said first conducting path to respectively close and open said second switches in response to said first switches of opposite paths being opened and closed; and,
a driving means for alternately driving one of said first switches open and the other closed for a first predetermined time period, and vice versa for a second predetermined time period.
2. A bi-phasic pulse generator as in claim 1 wherein is further included current-control, valve means connected in each of said paths between said first voltage terminal and said output electrodes to thereby control the flow of current through said electrodes.
3. A bi-phasic pulse generator as in claim 2, wherein said switches and control means comprise transistors.
4. A bi-phasic pulse generator as claimed in claim 1, wherein said driving means comprises a programming circuit means for alternately driving said first switches in a programmed sequence.
5. A bi-phasic pulse generator as claimed in claim 1, wherein said output electrodes include means for electrically attaching said electrodes to living tissue.
6. A bi-phasic pulse generator for producing pulses to stimulate living tissuecomprising:
first and second voltage terminals having different voltage potentials thereon;
of said electrodes including electronic valve means for selectively controlling the magnitude of current flow between said first voltage terminal and both of said first and second electrodes; and a control means attached to said electronic valve means for selectively adjusting the flow of current through said valve means. 7. A bi-phasic pulse generator as claimed in claim 6 wherein said electronic valve means comprise transistors.
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|U.S. Classification||607/74, 607/40, 607/46, 607/42, 607/45, 607/9|
|Cooperative Classification||A61N1/36021, A61N1/36025|
|European Classification||A61N1/36E, A61N1/36|
|7 May 1990||AS||Assignment|
Owner name: VENTRITEX, INC., CALIFORNIA
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:AXOTRONICS, INC., A CORP. OF CT.;REEL/FRAME:005289/0451
Effective date: 19900420
|7 May 1990||AS02||Assignment of assignor's interest|
Owner name: AXOTRONICS, INC., A CORP. OF CT.
Effective date: 19900420
Owner name: VENTRITEX, INC., 709 EVELYN AVE., SUNNYVALE, CA. 9