US3916893A - Single-injection device - Google Patents

Single-injection device Download PDF

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Publication number
US3916893A
US3916893A US455014A US45501474A US3916893A US 3916893 A US3916893 A US 3916893A US 455014 A US455014 A US 455014A US 45501474 A US45501474 A US 45501474A US 3916893 A US3916893 A US 3916893A
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Prior art keywords
needle
container
end portion
syringe body
sleeve
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Expired - Lifetime
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US455014A
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Felice Wilfried De
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Hoechst AG
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Hoechst AG
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
    • A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase

Definitions

  • the present invention relates to a single-injection de vice consisting of a liquid container of special shape to be filled with a liquid medicament.
  • the sealed lower end of the container holds a syringe body which, however, may also cover the liquid container over its full length.
  • the interior of the syringe body is provided with a movable needle support and forms a sterile chamber together with a piston rod.
  • injection devices in which the medicament to be injected is stored in a liquid container, shaped as an ampoule which is pushed into a syringe body.
  • the ampoule placed in the syringe body will be pushed in only to such a point that the assembled injection cannula which reaches into the interior of the syringe body does not pierce the seal at the front end of the ampoule.
  • An essential disadvantage of that syringe is the injection needle fixed in the syringe body, since the needle portion which projects into the syringe body and the portion of the ampoule facing it have to be kept sterile. Because of the resulting space between the liquid container and the syringe body, however, micro-organisms can penetrate into the sterile zone within a certain length of time in storage.
  • the present invention makesit a point to provide a sterile zone for the injection needle not in the syringe body but in a sealed and separate part of the device. This is achieved by mechanically deforming the syringe body proper into engagement with the liquid container, thus providing a sealed sterile chamber.
  • FIG. 1 is a side view of the syringe
  • FIG. 2 is a longitudinal cross sectional view of the sy ringe with the syringe body shortened;
  • FIG. 3 is a longitudinal cross sectional view of the syringe with the syringe body covering the liquid container;
  • FIG. 3a is a top view of the upper end of the syringe as shown in FIG. 3.
  • FIG. 2, A and FIG. 3, B show the syringe body in its shortened form and in its long form respectively, the finger support 5 in the first case being part of the liquid container, whereas in the second case it is part of the syringe body.
  • the preferred method for securely fastening the container according to the invention is provided by thermically and megchanically deforming a projecting portion of the rim 4 (FIG. 3) of the syring body made of a suitable plastic material by means of a punch moved in the direction of the container axis so as to form beads (FIGS. 3 and 3a) to retain the container.
  • FIG. 1 A container 1 to be filled with a liquid medicament, a shortened and/or a long syringe body 2 and a piston rod 3 mounted on the syringe body.
  • the liquid container is sealed in a familiar manner at its rear end by means of a movable piston stopper 6 and at its lower end by means of an aluminium cap 7 having a central aperture, under which a rubber disk or a rubber stopper 8 is inserted.
  • the sealing plug of the rubber stopper is advantageously provided with a conical cavity, through which air bubbles, which frequently form in the interior of the container filled with the liquid medicament prior to the application, can simply be removed by pressing the piston rod.
  • the liquid container 1 may be separated from a bore 9 holding the needle support 10, with a cannula ll passing through, by means of a plastic membrane 12, which may be injection-molded onto the syringe body 2, which is made of a plastic material.
  • the surface of the needle support 10 is provided with an annular projection 13 which engages an annular groove 14 cut in the bore 9, thus securing the needle support 10 in its initial position. This prevents premature perforation of the membrane 12 and the piercing of the rubber disk or stopper 8 placed under the aluminium cap 7.
  • the lower end of the needle support 10 is frustroconical, preferably shaped as a record frustrum l6, and has a shoulder 17, so that a plastic socket 18 projecting in the interior of the piston rod 3 can engage the needle support 10.
  • a long cannula which,
  • the syringe body 2 with the piston rod 3 screwed on and the needle support 10 located inside it may be sterilized in ways already known, for example by using gamma rays.
  • the device is secured against inadvertent twisting of the piston rod 3 by spot welding, which also presents the advantage of tamper-proof sealing.
  • the piston rod 3 is turned until retained by a stop 21.
  • the injection needle is then placed on the record frustrum 16 of the needle support 10. It is also possible to use the injection cannula 11, which projects beyond the frustrum and is firmly connected to the needle support 10, as an injection needle.
  • the injection device of of the invention has the advantage that the whole can'- nula is located in a sterile chamber, that fractionation of the rubber disk or stopper and thus clogging of the cannula are avoided to a large extent and that, in the case of a long syringe body, provision of retaining beads ensures a locking effect which is superior to conventional types and, inter alia, ensures perfect aspira tion.
  • the retaining beads provide a reliable means of preventing the liquid container from falling out of the syringe or being exchanged unintentionally.
  • a single-injection syringe comprising a container for a medicament; said container having first and second open end positions; said first end portion of the container having a penetrable seal mounted therein for sealing said first end portion, and said second end portion having a piston inserted therein to define with said seal a chamber for containing the medicament; a sy ringe body mounted on and surrounding said first end portion of the container; said syringe body having a penetrable end wall extending across said first end portion of the container and an elongated generally cylindrical sleeve integrally formed with and extending from said wall; said sleeve having an elongated bore formed therein extending from said end wall to an open end located in spaced relation from said end wall and a threaded external periphery; a needle support mounted in said bore for movement between first and second positions therein; said needle support having a diameter which is slightly less than the diameter of said bore and including an annular projection formed thereon and at least four stabilizing fins

Abstract

A single-injection syringe, including a liquid container to be filled with the medicament, and holding at its sealed lower end a shortened or long syringe body which, in its interior, carries a movable needle support and forms with a piston rod a sterile chamber.

Description

[ Nov. 4, 1975 United States Patent [1 1 De Felice V N 8 l 2 8 2 I M e r. h 10. K
[ SINGLE-INJECTION DEVICE [75] Inventor: Wilfried De Felice, Kelkheim,
Taunus, Germany [73] Assignee: Hoechst Aktiengesellschaft,
VDARR 8D88 o en 8288 WZWZZ 1 11 mm m m N udd wmmmm m KKm e dd m d m mwu nIIS r a n n u FCUUA 06096 65766 99999 HHHHH 03957 99 26 5722 235 8 32054 w e G .m m
4 7 m9 n 1 a 6 4 m 2 1 m 0 m x s F M 4 0 N m 0 p F A 1. 1 2 l 2 2 I .1
[30] Foreign Application Priority Data PrimaryExaminerRichard A. Gaudet Mar. 28, 1973 Assistant 0P1ltz Attorney, Agent, or Firm-Curtis, Morris & Safford ABSTRACT A single-injection syringe, including a liquid container 1. 7 5 r1 mRM Hyoooo 2 ll M22 2 IIDMMN m 28 n 1 WWV MM P mm oo mnn2 "m mu A mm HD umuoo n m m m Mm m m 8 l m m Q 1 I 0 Cmu m l m UhF 1:1] 2 8 555 to be filled with the medicament, and holding at its 5 References Cited sealed lower end a shortened or long syringe body which, in its interior, carries a movable needle support UNITED STATES PATENTS and forms with a piston rod a sterile chamber.
I-Ioskins 2,542,814 2/1951 128/218 D 3,084,688 4/1963 McConnaughey 128/218 NV 4 Claims, 4 Drawing Figures n lnrlululnlllllllfil llll 1 SINGLE-INJECTION nnvrca The present invention relates to a single-injection de vice consisting of a liquid container of special shape to be filled with a liquid medicament. The sealed lower end of the container holds a syringe body which, however, may also cover the liquid container over its full length. The interior of the syringe body is provided with a movable needle support and forms a sterile chamber together with a piston rod.
So-called ready-to-use syringes used for a single injection are already widely employed in the medicinal administration technique. Owing to the many individual parts of such wholesale articles, the assembly to be made under sterile conditions involves considerable cost. Since a ready-to-use syringe is destined for one injection only, the manufacturer will strive to keep the production costs thereof as low as possible.
Prior art knows injection devices, in which the medicament to be injected is stored in a liquid container, shaped as an ampoule which is pushed into a syringe body. In the final assembly, the ampoule placed in the syringe body will be pushed in only to such a point that the assembled injection cannula which reaches into the interior of the syringe body does not pierce the seal at the front end of the ampoule. An essential disadvantage of that syringe is the injection needle fixed in the syringe body, since the needle portion which projects into the syringe body and the portion of the ampoule facing it have to be kept sterile. Because of the resulting space between the liquid container and the syringe body, however, micro-organisms can penetrate into the sterile zone within a certain length of time in storage.
The present invention makesit a point to provide a sterile zone for the injection needle not in the syringe body but in a sealed and separate part of the device. This is achieved by mechanically deforming the syringe body proper into engagement with the liquid container, thus providing a sealed sterile chamber.
The syringe, constructed in accordacne with the present invention, will now be described in greater detail by way of example only with reference to the accompanying drawings, in which:
FIG. 1 is a side view of the syringe;
FIG. 2 is a longitudinal cross sectional view of the sy ringe with the syringe body shortened;
FIG. 3 is a longitudinal cross sectional view of the syringe with the syringe body covering the liquid container;
FIG. 3a is a top view of the upper end of the syringe as shown in FIG. 3.
Referring to the drawings, FIG. 2, A and FIG. 3, B show the syringe body in its shortened form and in its long form respectively, the finger support 5 in the first case being part of the liquid container, whereas in the second case it is part of the syringe body.
If the liquid container to be filled with the medicament has such a shape that no means is provided for a firm connection with the syringe body, the preferred method for securely fastening the container according to the invention is provided by thermically and megchanically deforming a projecting portion of the rim 4 (FIG. 3) of the syring body made of a suitable plastic material by means of a punch moved in the direction of the container axis so as to form beads (FIGS. 3 and 3a) to retain the container. These retaining beads Qprevent the liquid container from being removed, while compensating for differences in the total length of the liquid container, as do also various securing means of injection devices as presently used, for example stoppets with annular sealing lamellae or threads or socalled bayonet-type sealings.
To overcome the above-mentioned disadvantages l have now developed a new syringe system comprising essentially the following three main parts, as shown in FIG. 1: A container 1 to be filled with a liquid medicament, a shortened and/or a long syringe body 2 and a piston rod 3 mounted on the syringe body.
Referring to FIGS. 2 and 3, the liquid container is sealed in a familiar manner at its rear end by means of a movable piston stopper 6 and at its lower end by means of an aluminium cap 7 having a central aperture, under which a rubber disk or a rubber stopper 8 is inserted. The sealing plug of the rubber stopper is advantageously provided with a conical cavity, through which air bubbles, which frequently form in the interior of the container filled with the liquid medicament prior to the application, can simply be removed by pressing the piston rod.
The liquid container 1 may be separated from a bore 9 holding the needle support 10, with a cannula ll passing through, by means of a plastic membrane 12, which may be injection-molded onto the syringe body 2, which is made of a plastic material. Moreover, the surface of the needle support 10 is provided with an annular projection 13 which engages an annular groove 14 cut in the bore 9, thus securing the needle support 10 in its initial position. This prevents premature perforation of the membrane 12 and the piercing of the rubber disk or stopper 8 placed under the aluminium cap 7. Four stabilizing fins 15, running perpendicular to the plane of the annular projection 13 on the needle support 10, assure pefect centering in the bore 9.
The lower end of the needle support 10 is frustroconical, preferably shaped as a record frustrum l6, and has a shoulder 17, so that a plastic socket 18 projecting in the interior of the piston rod 3 can engage the needle support 10. In the case of a long cannula which,
as the same time, is the injection needle, a frustrum 18 is not required.
The syringe body 2 with the piston rod 3 screwed on and the needle support 10 located inside it may be sterilized in ways already known, for example by using gamma rays. The device is secured against inadvertent twisting of the piston rod 3 by spot welding, which also presents the advantage of tamper-proof sealing.
In order to operate the syringe of the invention, the piston rod 3 is turned until retained by a stop 21. The
projecting end of the cannula 11 thereby pierces the plastic membrane 12 and the rubber sealing 8, thus establishing a communication to the injection solution. The piston rod 3 is then removed by simple reversed turning and screwed into the piston stopper 6 placed at the upper end of the medicament container 1.
The injection needle, the size of which depends on the intended injection, is then placed on the record frustrum 16 of the needle support 10. It is also possible to use the injection cannula 11, which projects beyond the frustrum and is firmly connected to the needle support 10, as an injection needle. The injection device of of the invention has the advantage that the whole can'- nula is located in a sterile chamber, that fractionation of the rubber disk or stopper and thus clogging of the cannula are avoided to a large extent and that, in the case of a long syringe body, provision of retaining beads ensures a locking effect which is superior to conventional types and, inter alia, ensures perfect aspira tion. The retaining beads provide a reliable means of preventing the liquid container from falling out of the syringe or being exchanged unintentionally.
I claim:
1. A single-injection syringe, comprising a container for a medicament; said container having first and second open end positions; said first end portion of the container having a penetrable seal mounted therein for sealing said first end portion, and said second end portion having a piston inserted therein to define with said seal a chamber for containing the medicament; a sy ringe body mounted on and surrounding said first end portion of the container; said syringe body having a penetrable end wall extending across said first end portion of the container and an elongated generally cylindrical sleeve integrally formed with and extending from said wall; said sleeve having an elongated bore formed therein extending from said end wall to an open end located in spaced relation from said end wall and a threaded external periphery; a needle support mounted in said bore for movement between first and second positions therein; said needle support having a diameter which is slightly less than the diameter of said bore and including an annular projection formed thereon and at least four stabilizing fins extending perpendicularly thereto into engagement with the bore; a needle mounted in said support having an end portion located within said bore in the first position of the needle support and piercing said end wall and said seal as it is moved to its second position; said bore of said sleeve having a pair of spaced annular grooves formed therein respectively defining the first and second positions of said needle, said groove receiving and cooperating with said annular projection on the needle support to hold the needle support in its respective positions against inadvertent movement in the sleeve; and a hollow plunger including a first end portion threadably engaged with said threaded sleeve and operatively engaged in bearing engagement with said support, and a second end portion having means formed on the exterior thereof for engaging said piston when the plunger is removed from the sleeve; said needle support also including an annular shoulder formed thereon; and said plunger having an annular socket formed therein at its first end portion operatively engaging said annular shoulder in bearing engagement to urge said support towards the syringe body to cause the needle to pierce the end wall and seal upon rotation of the plunger on the sleeve when the plunger is rotated on the sleeve in a direction to move it towards the syringe body, said plunger having an elongated chamber formed therein receiving said needle, whereby said needle support forms, with the end wall of said syringe body an enclosed sterile chamber for the needle and is moved from its first to its second position to cause said needle to pierce said end wall and said seal when said plunger is threaded on the sleeve in a direction to move it towards the syringe body.
2. A syringe as claimed in claim 1 wherein said seal is a rubber stopper and has a conical cavity formed therein opening towards said chamber at the position at which the needle will pierce the'seal.
3. A syringe as claimed in claim 1 wherein said syringe body extends only about said first end portion of the container and the liquid container has a flanged-out finger support formed thereon.
4. A syringe as claimed in claim 1 wherein the syringe body surrounds the entire container and has, adjacent the second end portion of the container, radially inwardly extending beads overlying the container for retaining the liquid container in the syringe body.

Claims (4)

1. A single-injection syringe, comprising a container for a medicament; said container having first and second open end positions; said first end portion of the container having a penetrable seal mounted therein for sealing said first end portion, and said second end portion having a piston inserted therein to define with said seal a chamber for containing the medicament; a syringe body mounted on and surrounding said first end portion of the container; said syringe body having a penetrable end wall extending across said first end portion of the container and an elongated generally cylindrical sleeve integrally formed with and extending from said wall; said sleeve having an elongated bore formed therein extending from said end wall to an open end located in spaced relation from said end wall and a threaded external periphery; a needle support mounted in said bore for movement between first and second positions therein; said needle support having a diameter which is slightly less than the diameter of said bore and including an annular projection formed thereon and at least four stabilizing fins extending perpendicularly thereto into engagement with the bore; a needle mounted in said support having an end portion located within said bore in the first position of the needle support and piercing said end wall and said seal as it is moved to its second position; said bore of said sleeve having a pair of spaced annular grooves formed therein respectively defining the first and second positions of said needle, said groove receiving and cooperating with said annular projection on the needle support to hold the needle support in its respective positions against inadvertent movement in the sleeve; and a hollow plunger including a first end portion threadably engaged with said threaded sleeve and operatively engaged in bearing engagement with said support, and a second end portion having means formed on the exterior thereof for engaging said piston when the plunger is removed from the sleeve; said needle support also including an annular shoulder formed thereon; and said plunger having an annular socket formed therein at its first end portion operatively engaging said annular shoulder in bearing engagement to urge said support towards the syringe body to cause the needle to pierce the end wall and seal upon rotation of the plunger on the sleeve when the plunger is rotated on the sleeve in a direction to move it towards the syringe body, said plunger having an elongated chamber formed therein receiving said needle, whereby said needle support forms, with the end wall of said syringe body an enclosed sterile chamber for the needle and is moved from its first to its second position to cause said needle to pierce said end wall and said seal when said plunger is threaded on the sleeve in a direction to move it towards the syringe body.
2. A syringe as claimed in claim 1 wherein said seal is a rubber stopper and has a conical cavity formed therein opening towards said chamber at the position at which the needle will pierce the seal.
3. A syringe as claimed in claim 1 wherein said syringe body extends only about said first end portion of the container and the liquid container has a flanged-out finger support formed thereon.
4. A syringe as claimed in claim 1 wherein the syringe body surrounds the entire container and has, adjacent the second end portion of the container, radially inwardly extending beads overlying the container for retaining the liquid container in the syringe body.
US455014A 1973-03-28 1974-03-26 Single-injection device Expired - Lifetime US3916893A (en)

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DE2315367A DE2315367A1 (en) 1973-03-28 1973-03-28 SINGLE USE INJECTION SYRINGE

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DE (1) DE2315367A1 (en)
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US4067333A (en) * 1975-08-07 1978-01-10 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Syringe for storage and application of at least two injection media
US5250037A (en) * 1992-12-18 1993-10-05 Becton, Dickinson And Company Syringe having needle isolation features
US5324272A (en) * 1990-07-27 1994-06-28 Sterling Winthrop Inc. Multiple-celled safety package, needle guard and safe disposal module for prefilled medication cartridge
US5372590A (en) * 1990-07-27 1994-12-13 Habley Medical Technology Corporation Multi-celled safety package, needle guard and safety disposal module with sleeve for prefilled medication cartridges
US5693027A (en) * 1990-09-21 1997-12-02 Novo Nordisk A/S Adaptor top
US5718690A (en) * 1996-06-10 1998-02-17 Gettig Technologies, Incorporated Hypodermic injector system and method for maintaining the sterility thereof prior to use
FR2784033A1 (en) * 1998-10-01 2000-04-07 Marc Brunel SINGLE USE INJECTION DEVICE FOR PRE-FILLED
US20030078195A1 (en) * 2001-08-27 2003-04-24 Kristensen Lars Thougaard Cartridge and medical delivery system accommodating such cartridge
US20030109845A1 (en) * 2001-12-06 2003-06-12 Dca Design International Limited Medicament cartridge assembly
US20050065476A1 (en) * 2001-11-30 2005-03-24 Karsten Jensen Safety needle assembly
US20050171485A1 (en) * 2000-05-31 2005-08-04 Larsen Carsten G. Disposable double pointed injection needle, and an insulin injection system comprising a disposable double pointed injection needle
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US20090259197A1 (en) * 2006-07-15 2009-10-15 Novo Nordisk A/S Medical Delivery System with Flexible Blocking Element
US20090281505A1 (en) * 2006-07-15 2009-11-12 Novo Nordisk A/S Medical Delivery System with Asymmetrical Coding Means
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US20100010472A1 (en) * 2004-12-24 2010-01-14 Ian Marshall Moore Safety syringe
US20100010455A1 (en) * 2006-08-28 2010-01-14 Novo Nordisk A/S Medical Delivery System Adapted to be Locked Axially and Unlocked Rotationally
US20100042054A1 (en) * 2006-11-17 2010-02-18 Novo Nordisk A/S Medical Delivery System Comprising a Coding Mechanism Between Dosing Assembly and Medicament Container
US20100106099A1 (en) * 2006-12-21 2010-04-29 Novo Nordisk A/S Syringe Device
US20100324498A1 (en) * 2006-12-15 2010-12-23 Novo Nordisk A/S Medical delivery system comprising a container and a dosing assembly with radially moving fastening means
US20110046566A1 (en) * 2006-11-21 2011-02-24 Novo Nordisk A/S Medical Delivery System Comprising Locking Ring with L-Shaped Grooves
US20120179115A1 (en) * 2009-09-18 2012-07-12 Horvath Joshua Separable hub post of pen needle
US20130256166A1 (en) * 2010-12-14 2013-10-03 Becton Dickinson France Compact injection device
US8632506B2 (en) 2006-06-30 2014-01-21 Novo Nordisk A/S Medical delivery system comprising a coding mechanism
US20160136637A1 (en) * 2013-06-13 2016-05-19 Hamilton Bonaduz Ag Syringe having a mechanical coupling piece
US20160166765A1 (en) * 2011-10-14 2016-06-16 Amgen Inc. Injector and method of assembly
CN107929881A (en) * 2017-12-25 2018-04-20 江南大学 A kind of pharmaceutical preparation syringe integral structure
CN108495671A (en) * 2015-11-27 2018-09-04 赛诺菲-安万特德国有限公司 medicament injection apparatus
CN108601903A (en) * 2015-11-27 2018-09-28 赛诺菲-安万特德国有限公司 medicament injection apparatus
US10850037B2 (en) 2013-03-22 2020-12-01 Amgen Inc. Injector and method of assembly
US10898658B2 (en) 2016-07-06 2021-01-26 LynJohnston, LLC Compact injection device with telescoping components
US11097055B2 (en) 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
US11607502B2 (en) 2018-01-10 2023-03-21 LynJohnston, LLC Compact injector systems and methods

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Cited By (90)

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Publication number Priority date Publication date Assignee Title
US4067333A (en) * 1975-08-07 1978-01-10 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Syringe for storage and application of at least two injection media
US5324272A (en) * 1990-07-27 1994-06-28 Sterling Winthrop Inc. Multiple-celled safety package, needle guard and safe disposal module for prefilled medication cartridge
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AU6713274A (en) 1975-10-02
LU69713A1 (en) 1976-02-04
IT1010829B (en) 1977-01-20
CA1044104A (en) 1978-12-12
BE812955A (en) 1974-09-30
IN139269B (en) 1976-05-29
JPS49127494A (en) 1974-12-06
NL7403938A (en) 1974-10-01
FR2223051A1 (en) 1974-10-25
SE409077B (en) 1979-07-30
BR7402416D0 (en) 1974-12-03
DE2315367A1 (en) 1974-10-17
AR208661A1 (en) 1977-02-28
ATA253774A (en) 1979-07-15
GB1465281A (en) 1977-02-23
CH575765A5 (en) 1976-05-31
FR2223051B1 (en) 1977-10-07
AT355192B (en) 1980-02-25

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