US3908654A - Dispensing package for a dry biological and a liquid diluent - Google Patents

Dispensing package for a dry biological and a liquid diluent Download PDF

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US3908654A
US3908654A US49388074A US3908654A US 3908654 A US3908654 A US 3908654A US 49388074 A US49388074 A US 49388074A US 3908654 A US3908654 A US 3908654A
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Prior art keywords
container
needle
skirt
plug
liquid diluent
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Expired - Lifetime
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Willy Lhoest
Eloi Van Hoye
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Recherche et Industrie Therapeutiques
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Recherche et Industrie Therapeutiques
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Priority to US49388074 priority Critical patent/US3908654A/en
Priority to FR7522377A priority patent/FR2281037A7/en
Priority to DE19757524200U priority patent/DE7524200U/en
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Publication of US3908654A publication Critical patent/US3908654A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006—Piercing means
    • A61J1/201—Piercing means having one piercing end
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing

Definitions

  • a dispensing package for a dry biological and a liquid diluent has a hollow resilient member for containing a liquid diluent, said member being open at one end and having a nozzle at the other end with a removable closure.
  • a plug is secured in the open end of the hollow member and a skirt integral with the plug forms a chamber for the reception of a container.
  • a hollow needle secured in the plug is in communication with the interior of the hollow resilient member and extends into the interior of the skirt.
  • a container for a dry biological has a pierceable stopper and is frictionally engaged by the skirt in a position such that the end of the needle within the skirt is embedded in the pierceable stopper to block the flow of liquid through the needle. The stopper is spaced away from the plug. On the further advance of the container towards the plug, the needle passes through the stopper into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the nozzle on the removal of the nozzle closure.
  • a syringe type needle may be substituted for the nozzle to provide for subcutaneous or intramuscular administration.
  • the rubber stopper When it is desired to administer the medicament, the rubber stopper is removed from the needle and a separately packaged container is forced up against the needle to cause the needle to pierce through the piercable stopper of the container.
  • the I-Iein structure necessitates the separate packaging of the syringe element and the container for the dry biological. This requires an awkward manipula tion by the doctor or the patient involving the removal of the rubber stopper without spilling the liquid diluent and the interconnecting of the syringe element with the container.
  • these problems are entirely eliminated by providing a dispensing package which incorporates both the dispensing element and the container for the dry biological into a single unit which is activated for administration by a simple telescoping action with maximum sterility being maintained.
  • a dispensing package for a dry biological and a liquid diluent has a hollow resilient member for containing a liquid diluent, said member being open at one end and having a nozzle at the other end with a removable closure.
  • a plug is secured in the open end of the hollow member and a skirt integral with the plug forms a chamber for the reception of a container.
  • a hollow needle secured in the plug is in communication with the interior of the hollow member and extends into the interior of the skirt.
  • a container for a dry biological has a pierceable stopper and is frictionally engaged by the skirt in a position such that the end of the needle within the skirt is embedded in the pierceable stopper to block the flow of liquid through the needle.
  • the stopper is spaced away from the plug. On the further advance of the container towards the plug, the needle passes through the stopper into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the nozzle on the removal of the nozzle closure.
  • a syringe type needle may be substituted for the nozzle to provide for subcutaneous or intramuscular administration.
  • FIG. I is an exploded view of a dispensing package in accordance with the invention.
  • FIG. 2 is a side elevation of the dispensing package of FIG. I showing the elements in the shipping and storing configuration
  • FIG. 3 is an enlarged vertical section of the device of FIG. 2 partially broken away;
  • FIG. 4 is a vertical section through the device of FIG. 2 illustrating the position of the parts with the liquid diluent having been released into the container for the dry biological;
  • Nozzle 8 has a narrow passage 10 which is blocked by a twist off cap 12 which breaks off on a peripheral line of weakness shown at 13.
  • Other caps such as a screw cap can be used.
  • End 6 is closed by a plug 14 which has a passage 16 in which a hollow needle 18 is secured by a pressed fit. Needle 18 has a sharpened end 20 which extends downwardly within a skirt 24 which is integral with plug 14. Tube 4 contains a liquid diluent 26.
  • a container 30 typically containing a lyophilized biological tablet 32 is secured within skirt 24 by a frictional engagement with the skirt.
  • Container 30 has a pierceable stopper 34 of for example, rubber, which is held in position by a thin metal cap 36.
  • Cap 36 is frictionally engaged by a narrowed portion 40 of skirt 24. In the shipping and storing position shown in FIGS. 2 and 3, the cap 36 is spaced away from plug 14 and the needle 18 is lodged within stopper 34 with the end 20 completely blocked by the stopper to prevent diluent 26 from entering container 30.
  • container 30 When it is desired to administer the biological, container 30 is forced further into skirt 24 until hollow needle 18 pierces through stopper 24 at which time with the unit in a substantially upright position the liquid diluent 26 runs down into container 30 assisted if necessary by the squeezing of resilient tube 4.
  • the device After the tablet 32 is dissolved, the device is turned upside down and the liquid permitted to run into resilient tube 4 assisted by squeezing and releasing tube 4. The device is maintained in the same position and twist off cap 12 is removed by twisting it at the line of weakness 13.
  • the biological can then be dispensed, for example, into a nostril by squeezing resilient tube 4.
  • passage 10 is of a size such that the liquid diluent will not run out under the force of gravity.
  • the device of FIG. 2 may be modified to eliminate cap 12 and secure a syringe needle 50 in passage 10 by a pressed fit.
  • a resilient cap 52 may be used as a stopper for needle 50 until admin istration is to be carried out.
  • the dispensing package of the invention is low in cost and disposable. It can be steam sterilized. It combines simplicity of operation with maximum sterility in reconstitution.
  • Dispensing package for a dry biological and a liquid diluent comprising:
  • a hollow resilient member for containing a liquid diluent open at one end and having a discharge opening at the other end
  • a hollow needle secured in said plug in communicatainer to permit the transfer of the liquid diluent tion with the interior of said hollow member and into the container and then back into the tube for extending into the interior of the skirt, administration through the discharge opening on a container for a dry biological having a pierceable the removal of the means closing the discharge stopper frictionally engaged by said skirt with said 5 opening.
  • needle having its end within the skirt embedded in 2.
  • a dispensing package in accordance with claim 1 the pierceable stopper to prevent the flow of liquid having a nozzle incorporating the discharge opening. through the needle and the stopper spaced away 3.

Abstract

A dispensing package for a dry biological and a liquid diluent has a hollow resilient member for containing a liquid diluent, said member being open at one end and having a nozzle at the other end with a removable closure. A plug is secured in the open end of the hollow member and a skirt integral with the plug forms a chamber for the reception of a container. A hollow needle secured in the plug is in communication with the interior of the hollow resilient member and extends into the interior of the skirt. A container for a dry biological has a pierceable stopper and is frictionally engaged by the skirt in a position such that the end of the needle within the skirt is embedded in the pierceable stopper to block the flow of liquid through the needle. The stopper is spaced away from the plug. On the further advance of the container towards the plug, the needle passes through the stopper into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the nozzle on the removal of the nozzle closure. A syringe type needle may be substituted for the nozzle to provide for subcutaneous or intramuscular administration.

Description

United States Patent [191 Lhoest et al.
[451 Sept. 30, 1975 [22] Filed: Aug. 2, 1974 [21] Appl. No.: 493,880
[52] US. CL. 128/218 M; 128/218 D; l28/D1G. 28; 222/130; 222/206; 222/541; 128/231 [51] Int. Cl. A6IM 05/00 [58] Field of Search 222/80, 130, 206, 541, 222/85; 128/218 M, 218 D, DIG. 28; 206/222 [56] References Cited UNITED STATES PATENTS 2/1968 Hein 222/85 3.636.950 1/1972 Gomez et a1... 206/222 X 3.724.460 4/1973 Gomez et a1. 128/218 M FOREIGN PATENTS OR APPLICATIONS 1.545.963 10/1968 France 206/222 Irinmry E.raminer-Allcn N. Knowles Assistant Examiner-David A. Schcrbel Attorney, Agent, or Firm-Smith, Harding, Earley & Follmer 5 7 ABSTRACT A dispensing package for a dry biological and a liquid diluent has a hollow resilient member for containing a liquid diluent, said member being open at one end and having a nozzle at the other end with a removable closure. A plug is secured in the open end of the hollow member and a skirt integral with the plug forms a chamber for the reception of a container. A hollow needle secured in the plug is in communication with the interior of the hollow resilient member and extends into the interior of the skirt. A container for a dry biological has a pierceable stopper and is frictionally engaged by the skirt in a position such that the end of the needle within the skirt is embedded in the pierceable stopper to block the flow of liquid through the needle. The stopper is spaced away from the plug. On the further advance of the container towards the plug, the needle passes through the stopper into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the nozzle on the removal of the nozzle closure. A syringe type needle may be substituted for the nozzle to provide for subcutaneous or intramuscular administration.
3 Claims, 5 Drawing Figures Pia US. Patent Sept. 30,1975
FIG.4.
DISPENSING PACKAGE FOR A DRY BIOLOGICAL AND A LIQUID DILUENT BACKGROUND OF THE INVENTION I-Iein US. Pat. No. 3,369,708 discloses a dispensing package for a dry biological and a liquid diluent having a syringe element with a needle at one end and a nozzle at the other end and a container with a pierceable stopper containing a dry biological. A rubber stopper is provided to prevent liquid diluent from running out of the syringe element through the needle. When it is desired to administer the medicament, the rubber stopper is removed from the needle and a separately packaged container is forced up against the needle to cause the needle to pierce through the piercable stopper of the container. The I-Iein structure necessitates the separate packaging of the syringe element and the container for the dry biological. This requires an awkward manipula tion by the doctor or the patient involving the removal of the rubber stopper without spilling the liquid diluent and the interconnecting of the syringe element with the container. In accordance with this invention these problems are entirely eliminated by providing a dispensing package which incorporates both the dispensing element and the container for the dry biological into a single unit which is activated for administration by a simple telescoping action with maximum sterility being maintained.
BRIEF SUMMARY OF THE INVENTION A dispensing package for a dry biological and a liquid diluent has a hollow resilient member for containing a liquid diluent, said member being open at one end and having a nozzle at the other end with a removable closure. A plug is secured in the open end of the hollow member and a skirt integral with the plug forms a chamber for the reception of a container. A hollow needle secured in the plug is in communication with the interior of the hollow member and extends into the interior of the skirt. A container for a dry biological has a pierceable stopper and is frictionally engaged by the skirt in a position such that the end of the needle within the skirt is embedded in the pierceable stopper to block the flow of liquid through the needle. The stopper is spaced away from the plug. On the further advance of the container towards the plug, the needle passes through the stopper into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the nozzle on the removal of the nozzle closure. A syringe type needle may be substituted for the nozzle to provide for subcutaneous or intramuscular administration.
BRIEF DESCRIPTION OF THE DRAWING FIG. I is an exploded view of a dispensing package in accordance with the invention;
FIG. 2 is a side elevation of the dispensing package of FIG. I showing the elements in the shipping and storing configuration;
FIG. 3 is an enlarged vertical section of the device of FIG. 2 partially broken away;
FIG. 4 is a vertical section through the device of FIG. 2 illustrating the position of the parts with the liquid diluent having been released into the container for the dry biological; and
resilient plastic such as polyethylene, polypropylene or polyvinyl chloride, with an open end 6 and a nozzle 8 O at the other end. Nozzle 8 has a narrow passage 10 which is blocked by a twist off cap 12 which breaks off on a peripheral line of weakness shown at 13. Other caps such as a screw cap can be used.
End 6 is closed by a plug 14 which has a passage 16 in which a hollow needle 18 is secured by a pressed fit. Needle 18 has a sharpened end 20 which extends downwardly within a skirt 24 which is integral with plug 14. Tube 4 contains a liquid diluent 26.
A container 30 typically containing a lyophilized biological tablet 32 is secured within skirt 24 by a frictional engagement with the skirt. Container 30 has a pierceable stopper 34 of for example, rubber, which is held in position by a thin metal cap 36. Cap 36 is frictionally engaged by a narrowed portion 40 of skirt 24. In the shipping and storing position shown in FIGS. 2 and 3, the cap 36 is spaced away from plug 14 and the needle 18 is lodged within stopper 34 with the end 20 completely blocked by the stopper to prevent diluent 26 from entering container 30.
When it is desired to administer the biological, container 30 is forced further into skirt 24 until hollow needle 18 pierces through stopper 24 at which time with the unit in a substantially upright position the liquid diluent 26 runs down into container 30 assisted if necessary by the squeezing of resilient tube 4. After the tablet 32 is dissolved, the device is turned upside down and the liquid permitted to run into resilient tube 4 assisted by squeezing and releasing tube 4. The device is maintained in the same position and twist off cap 12 is removed by twisting it at the line of weakness 13. The biological can then be dispensed, for example, into a nostril by squeezing resilient tube 4. Advantageously, passage 10 is of a size such that the liquid diluent will not run out under the force of gravity.
As shown in FIG. 5 where a subcutaneous or intramuscular injection is desired, the device of FIG. 2 may be modified to eliminate cap 12 and secure a syringe needle 50 in passage 10 by a pressed fit. A resilient cap 52 may be used as a stopper for needle 50 until admin istration is to be carried out.
The dispensing package of the invention is low in cost and disposable. It can be steam sterilized. It combines simplicity of operation with maximum sterility in reconstitution.
It will be understood that the above described embodiments are illustrative and not limiting.
We claim:
1. Dispensing package for a dry biological and a liquid diluent comprising:
a hollow resilient member for containing a liquid diluent open at one end and having a discharge opening at the other end,
removable means closing the discharge opening,
a plug in said one end,
a skirt integral with the plug forming a chamber for the reception of a container,
a hollow needle secured in said plug in communicatainer to permit the transfer of the liquid diluent tion with the interior of said hollow member and into the container and then back into the tube for extending into the interior of the skirt, administration through the discharge opening on a container for a dry biological having a pierceable the removal of the means closing the discharge stopper frictionally engaged by said skirt with said 5 opening. needle having its end within the skirt embedded in 2. A dispensing package in accordance with claim 1 the pierceable stopper to prevent the flow of liquid having a nozzle incorporating the discharge opening. through the needle and the stopper spaced away 3. A dispensing package in accordance with claim 1 from the plug, whereby further advancing the conhaving an injection needle secured in the discharge tainer into the skirt causes the needle to pass opening.
through the pierceable stopper and into the con-

Claims (3)

1. Dispensing package for a dry biological and a liquid diluent comprising: a hollow resilient member for containing a liquid diluent open at one end and having a discharge opEning at the other end, removable means closing the discharge opening, a plug in said one end, a skirt integral with the plug forming a chamber for the reception of a container, a hollow needle secured in said plug in communication with the interior of said hollow member and extending into the interior of the skirt, a container for a dry biological having a pierceable stopper frictionally engaged by said skirt with said needle having its end within the skirt embedded in the pierceable stopper to prevent the flow of liquid through the needle and the stopper spaced away from the plug, whereby further advancing the container into the skirt causes the needle to pass through the pierceable stopper and into the container to permit the transfer of the liquid diluent into the container and then back into the tube for administration through the discharge opening on the removal of the means closing the discharge opening.
2. A dispensing package in accordance with claim 1 having a nozzle incorporating the discharge opening.
3. A dispensing package in accordance with claim 1 having an injection needle secured in the discharge opening.
US49388074 1974-08-02 1974-08-02 Dispensing package for a dry biological and a liquid diluent Expired - Lifetime US3908654A (en)

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US49388074 US3908654A (en) 1974-08-02 1974-08-02 Dispensing package for a dry biological and a liquid diluent
FR7522377A FR2281037A7 (en) 1974-08-02 1975-07-17 PACKAGING FOR THE PREPARATION AND ADMINISTRATION OF A COMPOSITION BASED ON A DRY BIOLOGICAL PRODUCT AND A LIQUID DILUENT
DE19757524200U DE7524200U (en) 1974-08-02 1975-07-30 DISTRIBUTION PACK FOR A DRY SERUM AND A LIQUID DILUTION AGENT

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DE7524200U (en) 1975-12-11

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