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Publication numberUS3906950 A
Publication typeGrant
Publication date23 Sep 1975
Filing date2 Apr 1974
Priority date4 Apr 1973
Also published asDE2415961A1, DE7411543U
Publication numberUS 3906950 A, US 3906950A, US-A-3906950, US3906950 A, US3906950A
InventorsCocozza Salvatore
Original AssigneeIsf Spa
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Inhaling device for powdered medicaments
US 3906950 A
Abstract
An inhaling device for medicinal powders comprising a pump and an inhaler wherein the inhaler has a cavity formed by the interconnection of two compartments for holding a puncturable capsule containing a medicinal powder. Two sliding needles acting against the action of return springs pierce the capsule. In a preferred embodiment, the lower body portion of the inhaler is attached to the pump when in use and may be stored in "at rest" position when the inhaler is inverted into the pump.
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tinited States @ocozza 1 INHALING DEVICE FOR POWDERED MEDICAMENTS [75] lnventor: Salvatore Cocozza, Milan, Italy [73} Assignee: I.S.F. S.p.A., Milan, ltaly [22] Filed: Apr. 2, 1974 [21] Appl. No.: 457,270

[30] Foreign Application Priority Data Apr. 4, 1973 Italy 22576/73 June 22, 1973 Italy; 25698/73 [52] US. Cl. 128/266; 128/206 [51] Int. Cl. A61M 13/00; A61M 15/08 [58] Field of Search 128/266, 206, 208, 194, 128/265 [56] References Cited UNITED STATES PATENTS 2,307,986 l/1943 Bolt et al. 128/266 so ,2 20* y 2,517,482 8/1950 Hall 128/206 2,519,555 8/1950 128/266 2,581,182 l/1952 128/206 2,946,332 7/1960 Sacks 128/266 3507277 4/1970 Altounyan et al 128/208 3,669,113 6/1972 Altounyan et a1. 128/266 Primary Examiner-Aldrich F. Medbery Attorney, Agent, or Firm-Depaoli & OBrien [57] ABSTRACT An inhaling device for medicinal powders comprising a pump and an inhaler wherein the inhaler has a cavity formed by the interconnection of two-compartments for holding a puncturable capsule containing a medici nal powder. Two sliding needles acting against the action of return springs pierce the capsule. In a preferred embodiment, the lower body portion of the inhaler is attached to the pump when in use and may be stored in at rest position when the inhaler is inverted into the pump.

22 Claims, 6 Drawing Figures r L 56o US Patent Sept. 23,1975 Sh6t 1 01 2 3,906,950

US mm Sept. 23,1975 Sheet 2' 0f 2 3,9,%

INHALING DEVICE FOR POWDERED MEDICAMENTS BACKGROUND OF THE INVENTION 1. Field of the Invention The invention relates to an inhaler for the administration of medicinal powders. More particularly, the inhaler relates to a traditional pump and an inhaler body having means for piercing a stored capsule containing medicinal powder.

2. Description of the Prior Art Inhalers are already known utilizing an elastic pump and a needle piercing a capsule which contains a me' dicinal substance; generally their working is not completely satisfactory as a result of rather complicated construction and cumbersome dimensions. In the in haler of the present invention, the above mentioned inconveniences have been practically eliminated, so that the inhaler is easily and quickly constructed and of reduced dimensions.

SUMMARY OF THE INVENTION It is the object of this invention to providean inhaler having simplified construction and reduced dimensions for use in combination with a conventional pump as an inhaling device for supplying medicinal powders to a body cavity.

It is another object to provide an inhaler having means for partial storage within the pump therefor.

It is an additional object to provide an inhaler having a means wheel to facilitate locking engagement with the pump.

It is a further object to provide an inhaler having a plurality of slidable alignment means. I

It is also an object to provide an inhaler having a spring-biased means for penetrating each end of a capsule stored therewithin.

In satisfaction of these objects and in accordance with the spirit of this invention, the inhaler contains a cavity-penetrating element. at one end thereof, through which air-entrained powder is forced out into a body cavity. a central element with an inside cavity for locating a capsule of medicinal powder therewithin. a pair of piercing devices for the endwise perforation of the capsule, and a base element having a polished surface interrupted by a ratchet wheel for connection with the pump. In more detail, the central element ofthe inhaler body is relatively fixed and formed by two components which are connected to each other, for example, by threading, bayonet insertion, and similar techniques. These components define a cavity therewithin, for placement of the capsule, and are slidably attached to a pair of relatively movable elements which hold piercing needles and which telescopically slide inside the two above-mentioned capsule holder components against the action of a pair of return springs.

The base element of the inhaler is so shaped that when the device is not in use, the inhaler body may be inverted into the pump, therby resulting in a noticeable reduction in overall size and a pleasant compact aspect of the whole which is aesthetically and practically favorable.

The inhaling device is adapted for delivering powdered substances in aerated form from a pierced capsule and comprises a pump and an inhaler, the inhaler comprising a relatively fixed central element formed by two connectable components and defining a cavity for reception of the capsule. and a pair of relatively moveable needle holder elements telescopically slidablc within the connectable components against the action of a pair of return springs. The components may be connected by screw means, a bayonet clutch means. or the like. Each of the pair of needle holder elements comprises a capsule-piercing needle. Each of the components is attached to a sleeve having an interior shoulder and each of the pair of needle holder elements has an outwardly disposed shoulder which is capable of reciprocating between a rest position against one of the interior shoulders and a ncedle-piercing position against one of the connectable components. The inhaler also comprises a nose piece and a pump piece and one of the pair of holder elements is locked by friction to the noscpiecc and the other of the pair of needle holder elements may be locked against the piece by mi cro-ribs having saw teeth.

BRIEF DESCRIPTION OF THE DRAWINGS The inhaler which constitutes the present invention is shown in the accompanying drawings of the preferred embodiment in which:

FIG. 1 represents a side elevation of the assembled inhaling device comprising the inhaler inserted in a pump in operative condition.

FIG. 2 is a side elevation similar to FIG. I with the inhaler inverted in the pump to reduce the size of the device while partially stored therewithin.

FIG. 3 is a longitudinal section through the inhaler while in uncompressed condition.

FIG. 4 is a longitudinal section of the inhaler. similar to FIG. 3 but with the inhaler in a compressed condition, while in operative combination with a pump.

FIG. 5 is a cross-section taken along lines 55 of FIG. 3, and

FIG. 6 is a side elevation of the noseward component of the cavity-forming element.

DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to the drawings. the inhaler 8 of this invention is employed in combination with a conventional pump 100 and comprises a central storage unit 10 having a central cavity defined by walls 13 within which a medicinal powder-container capsule 15 is inserted as needed by unscrewing a pair of compartments 20, 30. A pair of stop sleeves 60, 70 are non-slidably attached to the unit 10 and are outside of and in sliding relation to a pair of needle holders 40, containing a pair of capsule-puncturing needles 41, 51. The pair of stop sleeves 60, is also within and in sliding relation to a pair of end pieces, the nose piece and the pump piece 90, to which the holders 40, 50 are rigidly attached. The holders 40, 50 are biased away from the central cavity by a pair of springs 25, 35.

Coaxially disposed throughout the entire inhaler of this invention are a series of central holes for passage of air which enters the inhaler from the pump through base opening 98 and air passage 58, passes through the four air passages 59 shown in FIG. 5 to central hole 32 around pump needle 51, enters and passes through the punctured capsule 15 while entraining medicinal powder therefrom. travels past nose needle 41 through central hole 22, passes through the four air passages 49 into swirl compartment 83, and exits from the inhaler through discharge hole 81 in nosepiece 80.

The unit is formed by screwably connecting the nose compartment and the base compartment 30. The compartments 20, have coaxially disposed central holes 22, 32, annularly disposed spring wells 24, 34 which open away from the capsule 15, outer cylindrical recesses with surfaces 23, 33, and connecting screw threads 29, 39 by means of which the compartments 20, 30 are connected. Nose return spring 25 is seated within spring well 24, and pump return spring is seated within spring well 34.

Nose needle holder 40 and pump needle holder have somewhat l-l-shaped cross sections and comprise. respectively, annular fixed ends 46, 56 and annular sliding ends 47, 57 which rest against the springs 25, 35 within the spring wells 24, 34, as shown in FIG. 4. The holders 40, 50 also comprise four air passages 49, 59 which are separated by four radially spaced longitudinally disposed ribs, ribs 54 only being identified in FIG. 5. Each set of ribs 44, 54 supports a central portion containing a central needle recess which opens only toward the central cavity. The butt 42 of nose needle 41 and the butt 52 of pump needle 51 are each rigidly attached within these respective central needle recesses so that the respective needle points 43, 53 are coaxially aligned, centrally disposed within the central holes 22, 32, and in puncturing relationship to the ends of the capsule 15 within the range of compressibility of the springs 25, 35.

Additionally, the holders 40, 50 respectively comprise circumannular shoulders 45, 55 which extend outwardly exactly as far as the walls 23, 33 of the sleeve recesses of each compartment 20, 30. The circular sides 48, 58 of the shoulders 45, 55, opposite to the cavity for the capsule 15, function as a stop means in cooperation with the nose sleeve 60 and the pump sleeve 70, respectively, and the outer cylindrical surfaces of the shoulders 45, 55 are in sliding contact with the inner cylindrical surfaces 61, 71 of the sleeves 60, 70, thus functioning cooperatively therewith as an alignment means.

The nose and pump sleeve 60, respectively comprise elongated cylindrical portions, having outer sides 62, 72 and inner sides 61, 71, and inwardly extending interior shoulders 65, 75, having respective cavityfacing circular surfaces 66, 76, inner cylindrical surfaces 68, 78, and endward-facing circular surfaces 67, 77. The surfaces 68, 78 function as a sliding alignment means in cooperation with the cylindrical surfaces 46a, 56a of the fixed ends 46, 56 of the needle holders 40, 50. The inner side 61, 71 are non-slidably attached to the recessed outer surfaces 23, 33 and function cooperatively with the cylindrical outer surfaces of the shoulders 45, 55 as another sliding alignment means. Nonslidable attachment may be attained by means of suitable adhesive or by circumferential knurlings of the facing surfaces such as the knurlings 26 which are indicated in FIG. 6.

The nose piece 80 comprises a tapered penetration portion 82 through which passes the central discharge hole 81 therein. a skirt portion 84 which extends toward the cavity 15, and a stepped portion 85 therebetween. An annular recess coincides with the inner edge of the step portion 85 and penetrates longitudinally into the penetration portion 82. Into this annular recess, the fixed end 46 of the nose needle holder 40 is rigidly attached. as with an adhesive. The outer surface 62 of the nose sleeve 60 is in sliding engagement with the inner surface of the skirt 84 and functions cooperatively therewith as an alignment means.

The pump piece comprises an outer rim 91, a base 92 having an inwardly projecting circular lip to define the base opening 98, a circular lug 94 spaced pumpward from the edge of the rim 91, and circumferential serrations 97 along the inner surface of the base 92 and noseward of its circular lip. The lug 94 has a circular and arcuately receding surface 95, which acts as a storage stop means when the inhaler is in its inverted storage position shown in FIG. 2, and a circular and radially extending surface 96 which acts as an operational stop means when the inhaler is inserted into a conventional pump 100, as shown in FIGS. 1, 3, and 4. The serrations 97, which may be considered as ribbings, corrugations, or knurlings, are matched and engaged by similar serrations in the surfaces 56a.

The pump 100 typically has side walls 101, a circular top edge 102 which engages the surface 96 when the inhaler 8 is in operative position, and an air-containing interior 104 which should have sufficient depth to accommodate the inhaler 8 from the surface to the tip of the penetration portion 82 when the inhaler 8 is in stored position partially within the pump 100.

In summary, the inhaler 8 comprises three pairs of slidable alignment means:

I. inner cylindrical surfaces of skirt 84 and rim 91 in sliding contact with outer cylindrical surfaces 62, 72; 2. inner cylindrical surfaces 61, 71 in sliding contact with outer cylindrical surfaces of the shoulders 45, 55; and 3. inner cylindrical surfaces 68, 78 in sliding contact with outer cylindrical surfaces 46:1, 560. Because of these three pairs of slidable alignment means, the inhaler 8 possesses a high degree of trueness so that binding and wear are minimized.

In FIGS. 1-4, the profile of the cylindrical surface of the lower body portion of the inhaler 8, which is connected by friction with a pump of suitable dimensions and configuration, is polished and uniform and interrupted by the lug 94 where circular lines of contact 95 and 96 with the cylindrical surface represent the stop points in locking engagement with the pump 100 when the inhaler 8 is ready to use and when it is in storage position, respectively.

The inhaling device operates as follows:

Initially, the inhaler 8, inverted in the pump 100 (as shown in FIG. 2 is extracted therefrom and connected by friction locking in its upright position to the pump 100. Compartment 20 is then screwed off from compartment 30 and the capsule 15 of powder is inserted therein, after which nosepiece 80 and pumppiece 90 are moved towards one another, i.e., a contraction of the inhaler is caused along arrows AB, which creates two diametrally opposed perforations in capsule 15. Compare FIG. 1 with FIG. 4. Thereafter, it is possible to press the pump 100 to provoke the passage of the powder content of the capsule into a human cavity, such as nasal cavity or other cavities of the human body.

The present invention is not to be limited to the specific embodiment having the scope and advantages described hereinbefore, for various modifications can be made without departing from the spirit of the invention which should he understood asbeihglimited onlyiby the scope of the accompanying"claimst a 1. An inhalingdeyice, for-delivering powderedsubstances in aerated form from a pierced capsule, comprisinga pumpand. an inhaler, said inhalercomprising:

A. a, relatively fixed central element formed by two connectahle components and def ini ng a cavity. for reception of said capsule, and

B. a pair of relatively movcable ncc dleiholde'r ielm ments including piercing means mounted therein, which are: i IN 4 i r H l. telescopically slidable within said'corinectable components against the action of a pair of return springs and in the path of movement of air through said inhaler,

2. disposed in mutually opposed relationship and in straddling relationship to said capsule, and

3. constituting a means for piercing said capsule when said springs are compressed by slidably moving said needle holder elements toward each other.

2. The inhaling device of claim 1 whereinsaid components are connected by screw means.

3. The inhaling device of claim 1 wherein each of said pair of needle holer elements comprises a capsulepiercing needle.

4. The inhaling device of claim 1 wherein each of said components is attached to a sleeve having an interior shoulder and each of said pair of needle holder elements has an outwardly disposed shoulder which is capable of reciprocating between a rest position against one of said interior shoulders and a needle-piercing position against one of said conncctable components.

5. The inhaling device of claim 4 wherein said inhaler comprises a nose piece and a pump piece and one of said pair of said needle holder elements is locked by friction to said nose piece and the other of said pair of needle holder elements is locked against said pump piece by micro-ribs having saw teeth.

6. An inhaler for storing, entraining, and delivering powders in aerated condition, comprising;

A. a central storage unit for said powders,

B. a pair of needle holders including piercing means mounted therein which straddle said unit and are slidably connected thereto,

C. a nose piece which is non-slidably attached to one of said pair of needle holders,

D. a pump piece which is non-slidably attached to the other of said pair of needle holders, and

E. a longitudinally disposed air passage means extending from end to end of said inhaler, through said pump piece, said pair of needle holders, said central storage unit, and said nose piece, said nose piece and said pump piece ecah being longitudinally slidable toward said central storage unit to provide opposed piercing means for the central storage unit, whereby said powders are released.

7. The inhaler of claim 6 wherein said central storage unit comprises a pair of connectable compartments which define and contain. in combination, a cavity thcrewithin for storage of a capsule containing said powder.

8. The inhaler of claim 7 wherein each of said pair of conncctable compartments comprises an annular spring well within which a compression spring is seated.

'9. T he inhaler of claim.8 wherein each of said pair of needle holderscomprises a annular sliding end which is;slidably mounted within one of said annular spring wells andinengagement-with one .Of said springs.

10. The inhaler of claim 9.which further comprises a pair of stop:slceves which straddle said. unit and are non-slidably attached thereto.

11:. The inhaler of claim 10 wherein said pair of stop sleeves is in slidably circumferential and alignmentma'intaining relation to said pair of needle holder element's. 1 I

"12.The inhaler of claim 11- wherein each of said pair of stop sleeves has a cylindrical inner wall and said needle holders comprise circumanntilar shoulders which extend outwardly into slidable and alignmentmaintaining relation with said cylindrical inner walls of said stop sleeves.

13. The inhaler of claim 12 wherein each of said pair of needle holders additionally comprises an annular fixed end, one of said fixed ends being non-slidably attached to said nose piece and the other being nonslidably attached to said pump piece.

14. The inhaler of claim 13 wherein each of said pair of needle holders comprises a capsule-piercing needle, said needles being coaxially disposed in mutually opposed relationship and in straddling relationship to said capsule and being adapted to pierce said capsule when said springs are compressed by slidably moving said nose piece and said pump piece toward each other.

15. The inhaler of claim 14 wherein each of said stop sleeves additionally comprises an inwardly extending interior shoulder which extends into sliding engagement with exterior cylindrical surfaces of said fixed ends, as a sliding alignment means.

16. The inhaler of claim 15 wherein:

A. said nosepiece, said stop sleeves, and said central storage unit have a smaller exterior diameter than the exterior diameter of said pump piece, and

B. said pump piece comprises a circumferential and outwardly extending lug having an arcuately recedingsurface and a radially receding surface,

whereby said arcuately receding surface functions as a storage stop means, when said inhaler is inverted into a pump for storage by inserting said nose piece thereinto, and said radially receding surface functions as an operational stop means, when said inhaler is inserted into said pump by engaging said pump piece therewith.

17. The inhaler of claim 16 wherein said pump piece further has an exterior cylindrical surface which is polished and uniformly interrupted by a friction locking means for the mouthpiece of said pump.

18. The inhaling device of claim 17 wherein the points of contact between the cylindrical surface of the lower body portion and the surface normal to said means are friction locking points between said inhaler and said pump.

19. The inhaling device of claim 17 wherein the points of contact between the cylindrical surface of the lower body portion and the portions of said means have curved surfaces which are stop points for friction locking between said inhaler and said pump when said inhaling device is not in use.

20. The inhaling device of claim 5 wherein:

A. said nose piece and said. pump piece each comprises a skirt portion extending toward said cavity and having an inner cylindrical surface adapted for sliding contact; and

B. each said sleeve comprises an outer cylindrical surface adapted for said sliding contact with one of said inner cylindrical surfaces of said skirt portions of said nose piece and said pump piece to form a first pair of slidable alignment means.

21. The inhaling device of claim wherein:

Apeach said sleeve, attached to one of said two conncctahle components. comprises an inner cylindrical surface adapted for sliding contact; and

B. each said outwardly disposed shoulder of said pair of needle holder elements comprises an outer cylindrical surface adapted for said sliding contact with one of said sleeves to form a second pair of slidable alignment means.

22. The inhaling device of claim 21 wherein:

A. each said interior shoulder of said sleeves attached to said two components comprises an inner cylindrical surface adapted for sliding contact: and

Bi each said needle holder element comprises an outer cylindrical surface adapted for said sliding contact with one of said inner cylindrical surfaces of said interior shoulders to form a third slidable alignment means. said first, second. and third pairs of slidable alignment means imparting a high degree of trueness to said inhaler so that binding and wear are minimized.

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Classifications
U.S. Classification128/203.15, 128/203.21
International ClassificationA61M15/00, A61M13/00
Cooperative ClassificationA61M2015/0033, A61M15/0028, A61M2202/064
European ClassificationA61M15/00C