US3902198A - Method of replacing a body part with expanded porous polytetrafluoroethylene - Google Patents
Method of replacing a body part with expanded porous polytetrafluoroethylene Download PDFInfo
- Publication number
- US3902198A US3902198A US457711A US45771174A US3902198A US 3902198 A US3902198 A US 3902198A US 457711 A US457711 A US 457711A US 45771174 A US45771174 A US 45771174A US 3902198 A US3902198 A US 3902198A
- Authority
- US
- United States
- Prior art keywords
- prosthesis
- fixation
- container
- microns
- fibrils
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/12—Mammary prostheses and implants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/14—Polytetrafluoroethylene, i.e. PTFE
Abstract
This invention provides an artificial vascular prosthesis suitable for implantation to replace damaged, stenosed, defective, or occluded veins or arteries. The prosthesis comprises a tube of expanded, porous polytetrafluoroethylene possessing a microstructure consisting of nodes interconnected by fibrils. The suitable range of fibrile length for such a prosthesis is 5-1000 microns, with the preferred range being 20100 microns.
Description
tJnite States Patent [191 Rathjen Sept. 2, 1975 [54] IMPLANTABLE PROSTHESIS HAVING A [56] References Cited REMOVABLE FIXATION MEANS UNITED STATES PATENTS 75] Inventor; Arthur H. Rathjen, Midl d 3,409,913 11/1968 Kantrowitz et al 3/1 Mich 3,093,831 6/1963 3,491,376 1/1970 [73] Assignee: Dow Corning Corporation, 3,514,791 6/1970 Midland, Mich 3,279,996 10/1966 Long, Jr. et al. 3/1 uxr Primar Examiner-Ronald L. Frinks l 3 M 20 1974 y [22] F1 ed ay Attorney,Agent, orFirm-Robert F. Fleming, Jr. 21] Appl. No.: 471,373
[57] ABSTRACT [52] CL g b g' Lg 2 This is an implanted prosthesis having easily removable fixation means. Theprosthesis includes a con- 51 Int. Cl. ..A6lf 1 24- A41c 3/10 miner, an attachment means and the fiXation means [58] Field of Search 3H, 36; 128/92, 334; 32/10 the attachment means is engageable with the fixation means by one or more loops.
4 Claims, 5 Drawing Figures BACKGROUND OF THE INVENTION There are several specific methods for restoring or improving normal body contour to the female breast either for cosmetic or support reasons. Two of these methods of achieving the required result are the use of an external removable prosthesis attached to the body by a harness arrangement or an implanted prosthesis.
Originally implanted prostheses were made from foam type materials, which tended to absorb body fluids and were susceptible to invasion by blood vessels and fibrous tissue that advantageously fixed the prosthesis in position but unfortunately caused the prosthesis to lose resiliency and to change in size. In the case of a breast prosthesis resilience is very important to most wearers.
The Pangman U.S. Patent 2,842,775 issued July 15, 1958 utilizes a breast implant having an external wall of foam material, a wall of impermeable material and an inner core of foam material, surrounded by the wall of impermeable material. The theory being that although the external wall will be invaded by blood vessels the wall of impermeable material will prevent the invasion from continuing into the inner core.
The patent to T. D. Cronin, U.S. Patent 3,293,663 issued December 27, 1966 discloses a breast prosthesis having a layer of porous material adhered by daubs of cement to the container. The porous material positions the container allowing tissue ingrowth and anchoring the prosthesis to the chest wall. The porous material may be cut in patches and adhered to different positions on the container. Loops ofmaterial are used in some cases as fixation means.
There are presently two schools of thought concerning tissue fixation of implantable prosthesis; either you use an implant fixation means or none at all. Surgeons that favor the latter approach maintain that omitting the fixation means provides a more resilient result without any considerable incidence of the implant moving away from the chest wall. All of the prostheses known to the applicant either have fixation means attached to the envelope or container of the prosthesis in such a manner that it would be very difficult to remove or do not have fixation means. This state of affairs requires manufacturers, distributors, and hospitals to maintain inventory of both types of prostheses.
SUMMARY OF THE INVENTION This invention is directed to an augmentation prosthesis comprising (1) a flexible container approximating the shape of the cavity to be filled, (2) an attachment pad adhered or otherwise attached to the rear wall of the container having attachment means associated with the pad and (3) a fixation means which may be removably engaged to the attachment pad. The attachment pad can also be engaged to any nonfixation implantable material where the choice of adding fixation is desirable.
An object of the present invention is to provide an implantable prosthesis which may be quickly converted from one with tissue fixation means to one without tissue fixation means.
Another object of the present invention is to provide an implantable prosthesis having an attachment pad engaged therewith the attachment pad having loops for engaging a fixation means.
BRIEF DESCRIPTION OFTHE DRAWINGS Other objects and attendant advantages of the present invention will become obvious to those skilled in the art from a reading of the following detailed description when read in conjunction with the accompanying drawings wherein:
FIG. 1 is a sectional view showing a type of prosthesis in place in a human breast.
FIG. 2 is a top plan view of the prosthesis shown' in FIG. 1 including the fixation strip showing the attachment strip dotted in to show engagement with the attachment pad.
FIG. 3 is a side elevation of the prosthesis shown in FIG. 2.
FIG. 4 is a top plan view of the prosthesis shown in FIG. 2 showing the loops covered with tape.
FIG. 5 is a top plan view of the prosthesis shown in FIG. 2 with the fixation strip only engaged to one loop.
DESCRIPTION OF PREFERRED EMBODIMENTS In the drawings there is shown a mammary prosthesis comprising an envelope or container 10 filled with a gel 12. The envelope 10 is formed of aflexible silicone rubber membrane and the gel 12 is a semifluid silicone of liquid methyl silicone resin capable of having a consistency which will provide resiliency and maintains the proper contour of the container 10. The container 10 could be of the type which can be inflated at the time of implantation such as disclosed in U.S. Patent 3,683,424. The container 10 can be formed in several ways such as by a dip process on a mandrel, by vacuum forming or by assembly of a cup portion to a back wall utilizing vulcanization or adhesion to join the two parts.
The container may be formed of a physiological inert elastomeric material which includes several plastics although the inventor prefers to use one of the family of silicone rubbers. Under certain circumstances organic rubbers made from butyl polymer or the natural polymer from the hevea tree could be utilized. The silicone rubbers which may be used in this invention can be either of the heat vulcanizing or room temperature vulcanizing type. Since these rubbers are intended for medical purposes, fillers, vulcanizing agents and other constituents should be chosen for their non-toxic, physiological inert characteristics.
A patch or attachment means 14 made of a flexible, physiological inert material such as the material used to form the container is adhered or otherwise attached to the rear wall 16 of the container 10. If desired, material from which the patch 14 is made may be reinforced. The patch 14 may have a rectangular, oval or other convenient shape and is fairly thin. The patch 14 includes a series of spaced loops 18 in transverse relation to the longitudinal axis of the patch 14. Each loop is formed by a pair of spaced, parallel slits, and is contiguous to the plane of the patch 14. The loop 18 can be bowed away from the plane and the remaining portion of the patch 14 allowing a fixation strip 20 to be inserted thereunder. The fixation strip 20 may be made of Dacron mesh or of any toxicologically acceptable, open lattice work such as sponge or Dacron felt.
Using the inventors prosthesis the surgeon may implant it with the fixation strip 20 if he desires ingrowth or remove the fixation strip and place the loops 18 in their contiguous position if he does not desire ingrowth. If desired, tape 22 formed of physiologically inert material may be placed over the loops 18 in their contiguous position to assure that accidental fixation with the loops does not take place.
As shown in FIG. 1 of the drawings if fixation is desired by the surgeon the loops 18 are engaged to the fixation strip 20 and over a period of time tissue from the chest wall, in the case of a mammary prosthesis, will grow into the interstices of the open lattice work, preventing inadvertent or undesired migration of the prosthesis. If the doctor should not desire a total fixation or should desire to suspend the prosthesis he can cut the anchoring means so that only the upper loop engages it and the lower two loops are pushed against the body of the container. On the other hand, he may desire to do this with the bottom loop or the bottom two loops only.
Another possibility is that after removal of the anchoring means a dab of implantable medical adhesive can be placed under the loop and the loop pushed against the container, thereby preventing fixation.
When fixation is desired, the doctor may secure the implant to adjacent tissue using absorbable sutures, thereby holding the implant in a desired position and location until ingrowth takes place.
Obviously the container may be shaped to support other animal body contouring such as the buttocks,
hips, testicles, or in cases of pectus excavatum, the chest.
That which is claimed is:
1. An implantable, prosthetic device for use in an animal body including a container having an external surface, attachment means associated with the external surface and the attachment means having tissue permeable anchoring means connected thereto, the attachment means including at least one loop engageable-with the anchoring means and the anchoring means easily separable from the attachment means and having a width less than the width of the external surface.
2. A prosthetic device as set forth in claim 1 wherein the anchoring means is formed of a thin sheet of material and is rectangular in configuration.
3. An implantable prosthetic device for use in an animal body including a container having an external surface, attachment means associated with the external surface and the attachment means having tissue permeable anchoring means connected thereto, the attachment means including at least one loop engageable with the anchoring means, the anchoring means formed of a thin sheet of physiological inert material, and rectangular in configuration, the anchoring means easily separable from the attachment means.
4. An implantable prosthetic device for use in an animal body including a container having an external surface, attachment means associated with the external surface and the attachment means having tissue permeable anchoring means connected thereto, the attachment means including at least one loop engageable with the anchoring means, the anchoring means formed of a thin sheet of physiological inert material, and easily separable from the attachment means, and the attachment means adhered to the external surface of the container.
Claims (6)
1. The method of replacing a part of the body by a device comprising expanded, porous polytetrafluoroethylene possessing a microstructure consisting of nodes interconnected by fibrils, wherein the length of substantially all of said fibrils exceeds 5 microns.
2. The method of claim 1 for replacing a vascular conduit by a tube of expanded, porous polytetrafluoroethylene wherein the length of substantially all of said fibrils exceeds 5 microns.
3. The method of claim 2 wherein the length of substantially all of said fibrils falls within the range 5-1000 microns.
4. The method of claim 3 wherein the expanded, porous polytetrafluoroethylene possesses a matrix tensile strength in at least one direction exceeding 7,300 psi.
5. The method of claim 3 wherein said fibrils are about 20-100 microns in length.
6. The method of claim 4 wherein said fibrils are about 20-100 microns in length.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AR25785375A AR205110A1 (en) | 1974-04-02 | 1975-01-01 | ARTIFICIAL VASCULAR PROSTHESIS |
AU78622/75A AU493280B2 (en) | 1974-04-02 | 1975-02-27 | Artificial prosthetic devices |
DE19752508570 DE2508570C2 (en) | 1974-04-02 | 1975-02-27 | Vascular prosthesis made of expanded and porous polytetrafluoroethylene |
GB1156375A GB1506432A (en) | 1974-04-02 | 1975-03-20 | Prosthetic device |
FR7509900A FR2265345B1 (en) | 1974-04-02 | 1975-03-28 | |
SE7503734A SE418922B (en) | 1974-04-02 | 1975-04-01 | PROTEST INCLUDING EXPANDED, POROS POLYTETRAFLUORET |
JP3929775A JPS5339719B2 (en) | 1974-04-02 | 1975-04-02 | |
HK62983A HK62983A (en) | 1974-04-02 | 1983-12-01 | Prosthetic device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47137374A | 1974-05-20 | 1974-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3902198A true US3902198A (en) | 1975-09-02 |
Family
ID=23871375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US457711A Expired - Lifetime US3902198A (en) | 1974-04-02 | 1974-04-02 | Method of replacing a body part with expanded porous polytetrafluoroethylene |
Country Status (3)
Country | Link |
---|---|
US (1) | US3902198A (en) |
JP (1) | JPS5340278B2 (en) |
CA (1) | CA1048205A (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1981001650A1 (en) * | 1979-12-17 | 1981-06-25 | Dow Corning | Silicone gel-filled silicone rubber article possessing reduced surface-bleed |
US4472226A (en) * | 1979-10-03 | 1984-09-18 | Minnesota Mining And Manufacturing Company | Silicone gel filled prosthesis |
FR2542606A1 (en) * | 1983-03-18 | 1984-09-21 | Roehm Gmbh | IMPLANTABLE SYNTHETIC MATERIAL, PARTICULARLY FOR A BREAST PROSTHESIS |
US4769036A (en) * | 1985-07-17 | 1988-09-06 | Jamal Modir | Reconstructive mammary prosthesis |
US4773909A (en) * | 1981-10-06 | 1988-09-27 | Memorial Hospital For Cancer And Allied Diseases | Multi-lumen high profile mammary implant |
US4984585A (en) * | 1983-02-17 | 1991-01-15 | Austad Eric D | Tissue expander |
US5165425A (en) * | 1989-07-06 | 1992-11-24 | Dow Corning France S.A. | Method of forming a flap of tissue |
US5922023A (en) * | 1996-05-02 | 1999-07-13 | Amoena Medizin-Orthopaedie-Technik Gmbh & Co. | Breast prosthesis |
US6060639A (en) * | 1994-03-04 | 2000-05-09 | Mentor Corporation | Testicular prosthesis and method of manufacturing and filling |
US6395019B2 (en) | 1998-02-09 | 2002-05-28 | Trivascular, Inc. | Endovascular graft |
US20040176836A1 (en) * | 2003-03-06 | 2004-09-09 | Trivascular, Inc. | Kink resistant endovascular graft |
US6855159B1 (en) * | 1999-02-05 | 2005-02-15 | Eva Corporation | Surgical guide line assembly and separator assembly for use during a surgical procedure |
US7147661B2 (en) | 2001-12-20 | 2006-12-12 | Boston Scientific Santa Rosa Corp. | Radially expandable stent |
US7147660B2 (en) | 2001-12-20 | 2006-12-12 | Boston Scientific Santa Rosa Corp. | Advanced endovascular graft |
US7803178B2 (en) | 2004-01-30 | 2010-09-28 | Trivascular, Inc. | Inflatable porous implants and methods for drug delivery |
US8066755B2 (en) | 2007-09-26 | 2011-11-29 | Trivascular, Inc. | System and method of pivoted stent deployment |
US8083789B2 (en) | 2007-11-16 | 2011-12-27 | Trivascular, Inc. | Securement assembly and method for expandable endovascular device |
US8226701B2 (en) | 2007-09-26 | 2012-07-24 | Trivascular, Inc. | Stent and delivery system for deployment thereof |
US8328861B2 (en) | 2007-11-16 | 2012-12-11 | Trivascular, Inc. | Delivery system and method for bifurcated graft |
US8663309B2 (en) | 2007-09-26 | 2014-03-04 | Trivascular, Inc. | Asymmetric stent apparatus and method |
WO2014055120A1 (en) * | 2012-10-04 | 2014-04-10 | Lifecell Corporation | Surgical template and delivery device |
US8992595B2 (en) | 2012-04-04 | 2015-03-31 | Trivascular, Inc. | Durable stent graft with tapered struts and stable delivery methods and devices |
US9498363B2 (en) | 2012-04-06 | 2016-11-22 | Trivascular, Inc. | Delivery catheter for endovascular device |
US10159557B2 (en) | 2007-10-04 | 2018-12-25 | Trivascular, Inc. | Modular vascular graft for low profile percutaneous delivery |
US10537665B2 (en) | 2015-09-11 | 2020-01-21 | Lifecell Corporation | Perforated tissue matrix |
US10869745B2 (en) | 2016-10-06 | 2020-12-22 | Lifecell Corporation | Tissue matrix with preformed openings or pilot openings |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5832339U (en) * | 1981-08-20 | 1983-03-02 | シャープ株式会社 | electronic thermometer |
JPS603439U (en) * | 1983-06-22 | 1985-01-11 | 九州日立マクセル株式会社 | thermometer |
JPS60170749U (en) * | 1984-04-20 | 1985-11-12 | シャープ株式会社 | digital thermometer |
JPS61139443U (en) * | 1985-02-20 | 1986-08-29 | ||
JPS62186034U (en) * | 1986-05-20 | 1987-11-26 | ||
ES2724704T3 (en) * | 2007-11-14 | 2019-09-13 | G Patrick Maxwell | Interconnected Medical Implant Assembly |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3094762A (en) * | 1959-01-07 | 1963-06-25 | Us Catheter & Instr Corp | Tetrafluoroethylene resin tubing |
US3588920A (en) * | 1969-09-05 | 1971-06-29 | Sigmund A Wesolowski | Surgical vascular prostheses formed of polyester fiber paper |
-
1974
- 1974-04-02 US US457711A patent/US3902198A/en not_active Expired - Lifetime
-
1975
- 1975-01-22 CA CA75218429A patent/CA1048205A/en not_active Expired
- 1975-03-11 JP JP2945175A patent/JPS5340278B2/ja not_active Expired
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3094762A (en) * | 1959-01-07 | 1963-06-25 | Us Catheter & Instr Corp | Tetrafluoroethylene resin tubing |
US3588920A (en) * | 1969-09-05 | 1971-06-29 | Sigmund A Wesolowski | Surgical vascular prostheses formed of polyester fiber paper |
Cited By (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4472226A (en) * | 1979-10-03 | 1984-09-18 | Minnesota Mining And Manufacturing Company | Silicone gel filled prosthesis |
WO1981001650A1 (en) * | 1979-12-17 | 1981-06-25 | Dow Corning | Silicone gel-filled silicone rubber article possessing reduced surface-bleed |
US4773909A (en) * | 1981-10-06 | 1988-09-27 | Memorial Hospital For Cancer And Allied Diseases | Multi-lumen high profile mammary implant |
US4984585A (en) * | 1983-02-17 | 1991-01-15 | Austad Eric D | Tissue expander |
FR2542606A1 (en) * | 1983-03-18 | 1984-09-21 | Roehm Gmbh | IMPLANTABLE SYNTHETIC MATERIAL, PARTICULARLY FOR A BREAST PROSTHESIS |
US4769036A (en) * | 1985-07-17 | 1988-09-06 | Jamal Modir | Reconstructive mammary prosthesis |
US5165425A (en) * | 1989-07-06 | 1992-11-24 | Dow Corning France S.A. | Method of forming a flap of tissue |
US6060639A (en) * | 1994-03-04 | 2000-05-09 | Mentor Corporation | Testicular prosthesis and method of manufacturing and filling |
US5922023A (en) * | 1996-05-02 | 1999-07-13 | Amoena Medizin-Orthopaedie-Technik Gmbh & Co. | Breast prosthesis |
US8801769B2 (en) | 1998-02-09 | 2014-08-12 | Trivascular, Inc. | Endovascular graft |
US8361136B2 (en) | 1998-02-09 | 2013-01-29 | Trivascular, Inc. | Endovascular graft |
US7081129B2 (en) | 1998-02-09 | 2006-07-25 | Boston Scientific Santa Rosa Corp. | Endovascular graft |
US10548750B2 (en) | 1998-02-09 | 2020-02-04 | Trivascular, Inc. | Endovascular graft |
US9867727B2 (en) | 1998-02-09 | 2018-01-16 | Trivascular, Inc. | Endovascular graft |
US6395019B2 (en) | 1998-02-09 | 2002-05-28 | Trivascular, Inc. | Endovascular graft |
US7615071B2 (en) | 1998-02-09 | 2009-11-10 | Trivascular2, Inc. | Endovascular graft |
US6855159B1 (en) * | 1999-02-05 | 2005-02-15 | Eva Corporation | Surgical guide line assembly and separator assembly for use during a surgical procedure |
US7766954B2 (en) | 2001-12-20 | 2010-08-03 | Trivascular2, Inc. | Advanced endovascular graft |
US7147661B2 (en) | 2001-12-20 | 2006-12-12 | Boston Scientific Santa Rosa Corp. | Radially expandable stent |
US7147660B2 (en) | 2001-12-20 | 2006-12-12 | Boston Scientific Santa Rosa Corp. | Advanced endovascular graft |
US7150758B2 (en) | 2003-03-06 | 2006-12-19 | Boston Scientific Santa Rosa Corp. | Kink resistant endovascular graft |
US20040176836A1 (en) * | 2003-03-06 | 2004-09-09 | Trivascular, Inc. | Kink resistant endovascular graft |
US8267989B2 (en) | 2004-01-30 | 2012-09-18 | Trivascular, Inc. | Inflatable porous implants and methods for drug delivery |
US7803178B2 (en) | 2004-01-30 | 2010-09-28 | Trivascular, Inc. | Inflatable porous implants and methods for drug delivery |
US8226701B2 (en) | 2007-09-26 | 2012-07-24 | Trivascular, Inc. | Stent and delivery system for deployment thereof |
US8663309B2 (en) | 2007-09-26 | 2014-03-04 | Trivascular, Inc. | Asymmetric stent apparatus and method |
US8066755B2 (en) | 2007-09-26 | 2011-11-29 | Trivascular, Inc. | System and method of pivoted stent deployment |
US10682222B2 (en) | 2007-10-04 | 2020-06-16 | Trivascular, Inc. | Modular vascular graft for low profile percutaneous delivery |
US10159557B2 (en) | 2007-10-04 | 2018-12-25 | Trivascular, Inc. | Modular vascular graft for low profile percutaneous delivery |
US8328861B2 (en) | 2007-11-16 | 2012-12-11 | Trivascular, Inc. | Delivery system and method for bifurcated graft |
US8083789B2 (en) | 2007-11-16 | 2011-12-27 | Trivascular, Inc. | Securement assembly and method for expandable endovascular device |
US8992595B2 (en) | 2012-04-04 | 2015-03-31 | Trivascular, Inc. | Durable stent graft with tapered struts and stable delivery methods and devices |
US9498363B2 (en) | 2012-04-06 | 2016-11-22 | Trivascular, Inc. | Delivery catheter for endovascular device |
US9956072B2 (en) | 2012-10-04 | 2018-05-01 | Lifecell Corporation | Surgical template and delivery device |
WO2014055120A1 (en) * | 2012-10-04 | 2014-04-10 | Lifecell Corporation | Surgical template and delivery device |
US10537665B2 (en) | 2015-09-11 | 2020-01-21 | Lifecell Corporation | Perforated tissue matrix |
US11383007B2 (en) | 2015-09-11 | 2022-07-12 | Lifecell Corporation | Perforated tissue matrix |
US10869745B2 (en) | 2016-10-06 | 2020-12-22 | Lifecell Corporation | Tissue matrix with preformed openings or pilot openings |
Also Published As
Publication number | Publication date |
---|---|
JPS5340278B2 (en) | 1978-10-26 |
CA1048205A (en) | 1979-02-13 |
JPS50150297A (en) | 1975-12-02 |
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