Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.


  1. Advanced Patent Search
Publication numberUS3883901 A
Publication typeGrant
Publication date20 May 1975
Filing date27 Nov 1973
Priority date1 Dec 1972
Also published asCA1023493A, CA1023493A1, DE2359865A1
Publication numberUS 3883901 A, US 3883901A, US-A-3883901, US3883901 A, US3883901A
InventorsJean Coquard, Michel Ruaud, Pierre Sedivy, Jean Verrier
Original AssigneeRhone Poulenc Sa
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Method of replacing or repairing the body with bioresorbable surgical articles
US 3883901 A
Implantable surgical articles are provided which are at least partially bioresorbable and which consist at least partially of a polyester of succinic acid possessing a plurality of units of the general formula:
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

United States Patent 1 Coquard et al.

[73] Assignee: Rhone-Poulenc, S.A., Paris, France [22] Filed: Nov. 27, 1973 [21] Appl. No: 419,450

[30] Foreign Application Priority Data Dec. 1, 1972 France 72.42838 [52] US. Cl 3/1; 3/D1G. l; 128/92 B; 128/92 C; 128/334 R; l28/335.5; 260/78 A [51] Int. Cl A61f l/24; A611 17/00 [58] Field of Search 3/1, DIG. 1; 128/334 R, 128/334 C, 335.5, 92 C, 92 CA, 92 B, 92 D;

260/75 R, 75 T, 78 A [56] References Cited UNITED STATES PATENTS 2,071,250 2/1937 Carothers 260/78 A 1451 May 20, 1975 8/1969 Schmitt et a1 3/1 X 11/1971 Schmitt et a1 128/334 R OTHER PUBLICATIONS Polyesters, by V. V. Korshak, et a1., Pergamon Press, Oxford London, Edinburgh, New York, Paris, Frankfurt, 1965, pp. 31 and 53.

Primary ExaminerRonald L. Frinks Attorney, Agent, or Firm-Cushman, Darby & Cushman [57] ABSTRACT Implantable surgical articles are provided which are at least partially bioresorbable and which consist at least partially of a polyester of succinic acid possessing a plurality of units of the general formula:

in which R represents a linear or branched alkylene radical containing 2 to 6 carbon atoms. They are particularly suitable as sutures.

15 Claims, N0 Drawings METHOD OF REPLACING OR REPAIRING THE BODY WITH BIORESORBABLE SURGICAL ARTICLES The present invention relates to surgical articles which are biologically partially or completely resorbable after implantation in living human or animal tissues.

It is known that human or animal surgery is making use of more and more articles produced from natural or synthetic materials, in order to restore living tissues or to strengthen, repair and even replace various organs. For this purpose, surgical articles are placed in position either temporarily or permanently. In the case of temporary implantation, it has been considered preferable to make use of bioresorbable materials, that is to say materials which undergo degradation and which disappear after they have been implanted after a certain length of time, due to a biochemical process. It is important that the material used and its degradation products should not cause any unfavourable reaction of the surrounding tissues. With a permanent implantation, for example for replacing or strengthening a failing organ, non-resorbable articles are obviously used; it has been found, however, that in the majority of cases, the integration of the prosthesis and its joining to the adjacent tissues are facilitated if the prosthesis is made partly of a bioresorbable material which is gradually replaced by the adjacent tissues so as to form an intimate join between the latter and the implanted foreign body.

The elements for sutures and for ligatures intended for closing wounds and for repairing blood vessels, nerves and tendons are examples of surgical articles which are implanted temporarily. These elements are generally filaments, but they can also be in other forms, for example as clips or tapes. The most commonly used bioresorbable material for making suture or ligature filaments is catgut prepared from the collegen of mammals; the sub-muccous layer of the small intestine of sheep is most frequently employed. Catgut possesses numerous disadvantages, such as difficulty in obtaining it, the unfavourable reactions which it causes with living tissues and the lack of uniformity of its mechanical properties. Consequently, ways have been sought of replacing it by bioresorbable synthetic materials which can easily be converted into continuous filaments by extrusion techniques, and which possess readily reproducible mechanical properties. Various materials have been proposed for this purpose. Thus Belgian Pats. Nos. 679,726 and 758,156 describe elements for sutures and ligatures and other partially or completely bioresorbable surgical articles, which consist of polyesters of copolyesters derived from lactic acid and produced by polycondensation of a lactide (preferably a L-lactide) alone or combined with other derivatives of acid-alcohols such as glycolide, tetramethylglycolide, B-propiolactone and B-butyrolactone. Although they possess advantages relative to catgut, these polyesters are very sensitive to moisture and this has a detrimental effect on their mechanical properties so that it is necessary to store the surgical elements and especially the suture filaments made from them in hermetically sealed packaging. Hence they are not completely satisfactory.

In addition, it is known that it is important that the surgeon should have at his disposal various materials which provide him with a wide range of bioresorbable properties. In fact, the duration of the resorption varies with the nature of the wound and with the nature of the tissues involved in the cicatrization process; it also varies from one individual to another and with the type of insertion in the case of prosthesis. The development of new bioresorabable materials increases the number of possibilities from which the surgeon can choose and there is, consequently, a demand for new bioresorbable materials.

According to the present invention there is provided a surgical article which can be used in human or animal surgery, which is completely or partially bioresorbable and which consists wholly or partially of a bioresorbable material consisting of a polyester of succinic acid possessing a plurality of units of the general formula:

in which R represents a linear or branched alkylene radical containing 2 to 6 carbon atoms. More specifically, R can be an ethylene, methylethylene, 1,2- dimethylethylene, trimethylene, 2-methyltrimethylene, 2,Z-dimethyl-trimethylene, l-methyltrimethylene, tetramethylene, pentamethylene or hexamethylene radical.

The bioresorbable character shown by the polyesters of formula (I), denoted hereafter by the general term polysuccinate, is unexpected because it is known that polyesters such as polyethylene glycol terephthalate are not resorbed by human or animal tissues (see U.S. Pat. No. 3,463,158). It has been found that, in addition to their bioresorbable character, the polysuccinates are particularly well tolerated by the tissues in which they are implanted; thus no inflammatory reaction has been observed after a long-lasting implantation of polyethylene glycol succinate filaments in rats. Moreover, the polysuccinates possess excellent mechanical properties (notably tensile strength, tensile strength at knots and dimensional stability) and are insensitive to moisture, which make them particularly suitable for the manufacture of surgical articles and especially elements for sutures. Polysuccinate filaments are easy to handle and do not necessitate the use of special storage devices.

Polyglycol succinates have been known for a very long time (see, for example, U.S. Pat. No. 2,071,250; and V. V. KORSHAK and S. V. VINOGRADOVA, Polyesters, edited by PERGAMON PRESS Ltd., 1965, pages 31 to 46). They can be prepared by the usual polycondensation processes such as those described by V. V. KORSHAK and S. V. VINO- GRADOVA, loc. cit., or in HOUBEN WEYL, Methoden der Organische Chemie Makromolekulare Stoffe, volume 14/2, pages 1 to 29. Thus it is possible, for example, to use bulk polycondensation of glycols with free succinic acid or dimethyl succinate in the presence of the usual esterification or transesterification catalysts such as sulphuric or p-toluenesulphonic acids, or metal salts or oxides such as calcium oxide, strontium oxide, zinc oxide, aluminium oxide, bismuth oxide, iron oxide, titanium oxide, lead oxide, antimony oxide, cobalt oxide, calcium chloride, zinc acetate and zinc borates.

As glycols which can be used to prepare the polyesters used in the present invention, there may be mentioned ethylene glycol, propylene glycol, propane-1,3- diol, 2-methyl-propanel ,3-diol, 2,2-dimethylpropane-1,3-diol, butane-1,4-diol, butane-1,3-diol, butane-2,3-diol, pentane-1,5-diol and hexane-1,6-diol. These various glycols can be used separately or as a mixture with one another. Use can thus be made of mixtures containing 1 to 99 mol of ethylene glycol and 99 to 1 mol of one or more other glycols such as 2-methylpropane-1,3-diol and 2,2-dimethylpropane-1,3-diol.

The molecular weight of the polysuccinates used for the production of surgical articles according to the present invention can vary within very wide limits but it should generally be sufficiently high to render them suitable for the formation of films and fibres. Generally it should be sufficiently high for the polymer to be converted into filaments and films which can be orientated. The upper limit is not critical, subject to the condition that the product can be processed by the usual moulding or shaping techniques.

Polysuccinates can be used for the production of extremely diverse surgical articles, such as those described in Handbook of Biomedical Plastics, H. LEE and K. NEVILLE, 1971, Pasadena Technology Press. They are particularly suitable for the production of elements for surgical sutures and ligatures, especially in the form of twisted or non-twisted filaments, tapes, bristles, tents or spun fibres. They can also be used in the form of single filaments, twisted filaments, stranded filaments, gathered filaments, texturized filaments or lapped filaments; these various terms are used in accordance with the definition which is given of them in French Standard Specification NF G -005. These various elements for sutures can consist wholly or partially of the bioresorbable polysuccinates. Thus use can be made of a filament of the polysuccinate or of a filament comprising a core of a non-resorbable synthetic material such as polyethylene glycol terephthalate, polyamide or polypropylene, and an outer coating of polysuccinates. It is likewise possible to use a composite element consisting of a yarn of natural material, e.g., linen or silk, or synthetic material covered with a polysuccinate, or of a yarn of variable structure comprising bioresorbable filaments and nonresorbable filaments.

Amongst the other surgical articles for which the polysuccinates of the formula (1) can be used, there may be mentioned knitted fabrics comprising resorbable yarns and optionally non-resorbable yarns or nonresorbable yarns covered with a layer of polysuccinate; non-woven fabrics prepared from non-bioresorbable fibresand a resorbable binder; and sheets made from non-resorbable materials covered on one or both faces by a polysuccinate. The wholly or partially resorbable knitted and woven fabrics can be used in the form of sheaths intended to facilitate the implantation of diverse prostheses such as that described in French Pat. Nos. 2,031,699 and 2,071,172 for correcting valvular illnesses, and especially of the mitral valve; tubes for the removal of biological liquids (in particular, artificial ureters) as described in French Pat. No. 2,133,083, and vascular prostheses such as those described in French Pat. No. 2,112,032.

The polysuccinates of formula (1) are also very suitable for the production of surgical articles such as tubes of various shapes, for example Y-shaped tubes and T- shaped tubes, bars, plates, rings and screws, intended to be implanted temporarily or permanently. Partially or completely bioresorbable tubular prostheses have been described in US Pat. Nos. 2,127,903, 3,272,204, 3,304,557, 3,316,557, and 3,479,670 to which reference should be made for further details.

The shaping of the polysuccinates of formula (I) for the production of surgical articles can be carried out by the usual methods. Thus filaments, tapes or sheets can be produced by extrusion of the polymer in the molten state, followed by stretching at a sufficiently high ratio to cause the orientation of the chains of the polymer, and the fixing of the article thus produced.

The polysuccinates of formula (I) can contain various adjuvants such as fillers, dyestuffs and plasticizers which are chemically inert and do not bring about any reactions with the living tissues.

They can be used alone or mixed with nonbioresorbable materials, as indicated above, or with materials which are more or less resorbable in themselves, for example, respectively, polyesters of the polyethylene glycol terephthalate or adipate type, or of the polylactide or polyglycolide type.

The surgical articles according to the invention can be sterilized easily by the techniques usually employed in surgery, for example by radiation treatment.

The following Examples further illustrate the present invention.

EXAMPLE 1 1. Preparation of polyethylene glycol succinate 174g. (1 mol) of diethyl succinate, 93 g. (1.5 mols) of ethylene glycol, 0.280 g. of zinc acetate and 0.070 g. of antimony trioxide are introduced, under a stream of nitrogen, into a 300 cm glass flask equipped with a scraping stirrer, a gas inlet tube, a gas outlet tube, a thermometer, a thermostatically controlled metal heating bath and a distillation column provided with a condenser and a receiving container. The contents of the flask are heated to 180C., with stirring, and these conditions are maintained for 1 hour 30 minutes. The temperature of the reaction mixture is then raised to 240C., over the course of 50 minutes and the apparatus is connected to a vacuum pump in order to reduce the pressure in the apparatus to 0.1 mm.Hg over the course of 30 minutes. The whole is maintained under these conditions for 6 hours 30 minutes. The viscous, light brown reaction mixture is dissolved in hot dioxane and then reprecipitated with methanol. A product is obtained which is filtered off and dried at 80C. in a vacuum oven. In this way, 112 g. of polymer are obtained.

In all, 2 mols of ethanol, 0.368 mol of ethylene glycol and 0.07 mol of diethyl succinate are collected in the various distillates from the reaction. Taking account of the fact that a further 5 g. of polyester are recovered on the walls of the apparatus, the degree of polycondensation rises to 85.5%

The polyester thus obtained has a viscosity of 69 cm"*/g., measured at 25C., on a 4 g/l solution in chloroform and a viscosity of 70 cm/g, measured at 25C. in a 2 g/l solution in meta-cresol. lt melts at 104C., and is not decomposed by heating under nitrogen at 300C.

A filament of gauge 20 decitex is prepared from this polyester by inelt spinning under 30 bars and stretching the yarn issuing from the spinneret in a ratio of 7 at 55C. This filament possesses the following mechanical properties:

tensile strength in accordance with Standard Specification NF G 07,008, April 1961, 2 g/dicitex, elongation at break in accordance with Standard Specification NF G 07,008, 50%, tensile strength at knots, in accordance with Standard Specification NF G 07,008, 1.66 g/decitex, shrinkage in water at 40C. in accordance with Standard Specification BNMP 14,732/27 of February 1972 4% 2. Determination of the local tolerance of implant in rats Using the polyethylene glycol succinate obtained as described above, a stretched filament of diameter 300 to 400 p. is produced and is sterilized by immersion for 1 hour in 70 GL ethyl alcohol.

Samples of length 1 cm are implanted, with a curved needle, in rats (Caesarean Originated, Barrier Sustained) weighing 250 to 350 g; the implantation is carried out, on the one hand, in the paravertebral muscles, and on the other hand, under the skin of one of the sides of each animal. Four rats (2 male and 2 female) each received two implants. Two months after the implantation, the animals are killed and the muscular implantation region (implant and paravertebral muscular mass) and the subcutaneous implantation region (skin, implant and underlying muscular portion) are removed in each case. The following examinations are carried out on each specimen removed:

a. Macroscopic examination after transverse section of one of the ends of the muscular mass (intramuscular implant) or detachment of the skin at one end (subcutaneous implant) of each specimen.

b. Histological examination after fixing the specimens in BOUIN liquid, inclusion in paraffin, cutting of 5 p. thick sections and colouration by means of hemalun-phloxine saffron. The following results were obtained:

a. Macroscopic examination Two months after the implantation, no macroscopically detectable tissue reaction was observed either at the muscle level or at the subcutaneous tissue level.

b. Histological examination Reaction of the tissues This reaction is limited to a very inconspicuous fibrous sheath around the implant and to the presence of a few multinucleate giant macrophage and histiocyte cells situated in contact with the implant itself.

No change which could relate to a possible toxic effect of the material was detected on the sections.

In short, the local tolerance in rats is very good from the macroscopic point of view and from the histological point of view.

3. Determination of the bioresorbability in vitro The bioresorbability of the polyethylene glycol succinate produced above is determined by measuring the variation in the reduced viscosity of a sample of polymer taken in the form of flakes and incubated for varying periods of time in an enzyme extract. The test was carried out in the following manner:

a. Preparation of the enzyme extract Fauves de Bourgogne rabbits, of approximately 2.5 kg, are killed with chloroform. The muscles from the back and the thighs are removed and are frozen at 20C. They are then ground rapidly in a meat mincing machine. 300 g. of ground material are dispersed in 500 ml. of 0.2 M citrate buffer of pH 4.1, which have previously been cooled to +2". The suspension obtained is ground again twice for 1 minute (grinder turning at 2,000 revolutions/minute), with external cooling (ice and salt mixture at about -13C.) to keep the temperature of the homogenized material below +l0C. during the operation.

The homogenized material is then subjected to an ultrasonic treatment (frequency: 20 kHz) for 2 minutes with the same cooling precautions. It is then centrifuged at 6,500 G, at 0 for 20 minutes. The supernatant liquid, filtered through glass wool, forms the enzyme extract; its pH is approximately 4.5.

b. Reaction between the product to be investigated and the enzyme extract A sample of 100 mg. of the polymer to be investigated is incubated at 37C., with agitation (shaking table turning at revolutions/minute), in the following reaction mixture:

Enzyme extract 40 ml. Streptomycin sulphate 2 mg. Sodium salt of penicillin G 2 mg. Sodium nitride 8 mg.

This reaction mixture is renewed every day; during each renewal, the samples are carefully washed with distilled water.

In parallel,.other samples of mg. of the product to be investigated are incubated in reaction mixtures in which the enzyme extract is replaced by an inactivated enzyme extract (heating for 30 minutes at 100C.) or by 0.2 M citrate buffer of pH 4.5.

The product to be investigated, in the form of flakes, is enclosed in a guaze bag for the incubation.

c. Examination of the polymer after reaction After hours of incubation, the samples of the product to be investigated are recovered,washed several times with distilled water, drained on filter paper and dried under reduced pressure at 50C.

The reduced specific viscosity of solutions of the product in 1,2-dichloro-ethane, at 40C., as well as that of the product before incubation, is then determined.

The following results were obtained:

Nature of the incubation Reduced medium specific viscosity None 52 Citrate buffer 54 inactivated enzyme extract 56 Active enzyme extract 34 It is found, under these conditions, that incubation in the active enzyme extract results in considerable degradation of the polyester.

EXAMPLES 2 1. Preparation of polybutane-1,4-diol succinate 1 hour and then to 240C. over the course of 30 minutes, and the pressure is reduced to 0.1 mm.Hg over the course of 40 minutes. After 4 hours 40 minutes under these conditions, the reaction is stopped.

In this way, 146.7 g. (degree of polycondensation 85.3%) of greyish polymer are obtained which are dissolved in 400 cm of hot dioxane. The polymer is reprecipitatedby introducing the solution into 3 l. of methanol, and is then filtered off and dried at 50C., in vacuo. 138 g. of white polymer, having a viscosity of 94-97 cm lg, measured at 25C., in a 2 g/l solution in meta-cresol, and having a melting point of 1 14C., are recovered.

Filaments of gauge 21 decitex are prepared from the polymer thus produced by melt spinning under 61 bars and stretching at 85C.

The filaments possess the following mechanical properties:

elongation at break (Standard Specification NF G 07,008, April 1961) 50% tensile strength (Standard Specification NF G 07,008)

2. Implantation of a braid in rats The implantation is carried out on four rats of the same origin as in Example 1 and in a rigorously identical manner. After two months of implantation, the rats are killed and the same samples are removed and the same examinations carried out as in Example 1. The results obtained were as follows:

A. Macroscopic examination Two months after the implantation, no macroscopically detectable tissue reaction was observed either at the muscle level or at the subcutaneous tissue level.

B. Histological examination Reaction of the tissues The local tolerance is good; reaction to the implantation is limited to the immediate periphery of the implant and remains inconspicuous. No change in the tissue due to a toxic effect of the products was detected.

Resorption of the implants After two months of implantation, the number of strands visible in the sections of the intramuscular implants is 3 out of the originally present.

We claim:

1. in a method of repairing or replacing a part of the body of a human of non-human animal by incorporating either temporarily or permanently, a surgical article, the improvement wherein the surgical article consists at least partially of a polyester of succinic acid possessing a plurality of units of the general formula:

'c l C-0- in which represents a linear or branched alkylene radical containing 2 to 6.carbon atoms having a filmor filament-forming molecular weight.

2. The method according to claim 1 in which the polyester is polyethylene glycol succinate 3. The method according to claim 1 in which the surgical article is in the form of a suture element.

4. The method according to claim 3 in which the surgical article is in the form of a filament, bristle, single filament, twisted filament, stranded filament, gathered filament, texturized filament of lapped filament, tape, tent or spun fibre.

5. The method according to claim 1 in which the surgical article is in the form of a textile fabric.

6. The method according to claim 1 in which the polyester is combined with another material which is bioresorbable.

7. The method according to claim 6 in which the other material is selected from the group consisting of 11. The method according to claim 1 in which the surgical article is in the form of a tube.

12. The method according to claim 1 in which the surgical article is in the form of a bar.

13. The method according to claim 1 in which the surgical article is in the form of a plate.

14. The method according to claim 1 in which the surgical articleis in the form of a screw.

15. The method according to claim 1 in which the surgical article is in the form of a ring.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US2071250 *3 Jul 193116 Feb 1937Du PontLinear condensation polymers
US3463158 *9 Jan 196726 Aug 1969American Cyanamid CoPolyglycolic acid prosthetic devices
US3620218 *25 Aug 196916 Nov 1971American Cyanamid CoCylindrical prosthetic devices of polyglycolic acid
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3960152 *14 Mar 19751 Jun 1976American Cyanamid CompanySurgical sutures of unsymmetrically substituted 1,4-dioxane-2,5-diones
US4032993 *25 Jun 19755 Jul 1977Rhone-Poulenc IndustriesBioresorbable surgical articles
US4080969 *29 May 197528 Mar 1978American Cyanamid CompanySuture or ligature carrying on the exposed surface thereof a coating of a polyester resin
US4128612 *3 Nov 19755 Dec 1978American Cyanamid CompanyMaking absorbable surgical felt
US4141087 *19 Jan 197727 Feb 1979Ethicon, Inc.Isomorphic copolyoxalates and sutures thereof
US4186189 *28 Sep 197729 Jan 1980Ethicon, Inc.Absorbable pharmaceutical compositions based on poly(alkylene oxalates)
US4329743 *27 Apr 197918 May 1982College Of Medicine And Dentistry Of New JerseyBio-absorbable composite tissue scaffold
US4343931 *17 Dec 197910 Aug 1982Minnesota Mining And Manufacturing CompanySynthetic absorbable surgical devices of poly(esteramides)
US4388926 *22 Dec 198021 Jun 1983Ethicon, Inc.High compliance monofilament surgical sutures comprising poly[alkylene terephthalate-co-(2-alkenyl or alkyl)succinate]
US4396746 *6 Apr 19822 Aug 1983Daicel Chemical Industries, Ltd.Thermoplastic polyester copolymer
US4411027 *23 Feb 198225 Oct 1983University Of Medicine And Dentistry Of New JerseyBio-absorbable composite tissue scaffold
US4441496 *8 Feb 198210 Apr 1984Ethicon, Inc.Copolymers of p-dioxanone and 2,5-morpholinediones and surgical devices formed therefrom having accelerated absorption characteristics
US4481353 *7 Oct 19836 Nov 1984The Children's Medical Center CorporationBioresorbable polyesters and polyester composites
US4529792 *6 May 198216 Jul 1985Minnesota Mining And Manufacturing CompanyProcess for preparing synthetic absorbable poly(esteramides)
US4594407 *20 Sep 198310 Jun 1986Allied CorporationProsthetic devices derived from krebs-cycle dicarboxylic acids and diols
US4603695 *29 Jun 19845 Aug 1986Japan Medical Supply Co., Ltd.Use of molded polymeric material for preventing adhesion of vital tissues
US4652264 *25 Apr 198524 Mar 1987American Cyanamid CompanyProsthetic tubular article
US4662884 *25 Apr 19845 May 1987University Of Utah Research FoundationProstheses and methods for promoting nerve regeneration
US4670286 *26 Dec 19852 Jun 1987Allied CorporationMethod of forming prosthetic devices
US4738255 *7 Apr 198619 Apr 1988Biotron Labs, Inc.Suture anchor system
US4773416 *4 Feb 198727 Sep 1988Hourahane Donald HSurgery in horses
US4778467 *10 Jul 198618 Oct 1988The University Of UtahProstheses and methods for promoting nerve regeneration and for inhibiting the formation of neuromas
US4844067 *9 Feb 19884 Jul 1989Japan Medical Supply Co., Ltd.Sucrose fatty acid ester coated suture
US4870966 *1 Feb 19883 Oct 1989American Cyanamid CompanyBioabsorbable surgical device for treating nerve defects
US4871365 *24 Dec 19863 Oct 1989American Cyanamid CompanyPartially absorbable prosthetic tubular article having an external support
US4915893 *15 Jul 198310 Apr 1990Medtronic, Inc.Method of preparing polyester filament material
US5061281 *17 Dec 198629 Oct 1991Allied-Signal Inc.Bioresorbable polymers and implantation devices thereof
US5110852 *27 Oct 19885 May 1992Rijksuniversiteit Te GroningenFilament material polylactide mixtures
US5180392 *15 Nov 199019 Jan 1993Einar SkeieAnastomotic device
US5403346 *31 Dec 19924 Apr 1995Loeser; Edward A.Self-affixing suture assembly
US5434238 *23 Nov 199418 Jul 1995Eastman Chemical CompanyCopolyesters having repeat units derived from succinic acid
US5480962 *7 Mar 19942 Jan 1996Eastman Chemical CompanyCopolyesters having repeat units derived from succinic acid
US5498453 *2 Jun 199512 Mar 1996Eastman Chemical CompanyCopolyesters having repeat units derived from succinic acid
US5527342 *14 Dec 199318 Jun 1996Pietrzak; William S.Method and apparatus for securing soft tissues, tendons and ligaments to bone
US5589566 *1 Mar 199631 Dec 1996Eastman Chemical CompanyCopolyesters having repeat units derived from succinic acid
US5616681 *31 Oct 19951 Apr 1997Nippon Shokubai Co., Ltd.Process for producing aliphatic polyester
US5632753 *4 Apr 199527 May 1997Loeser; Edward A.Surgical procedures
US5843573 *25 Oct 19951 Dec 1998Nippon Shokubai Co., Ltd.Polyester resin composition
DE3249111C2 *9 Sep 19826 Feb 1986United States Surgical Corp., Norwalk, Conn., UsTitle not available
DE19857067B4 *10 Dec 199828 Jul 2005Ykk Corp.Verschlußelement aus biologisch abbaubarem Kunststoff
EP0144534A2 *16 Aug 198419 Jun 1985Allied Corporationprosthetic devices
EP0144534A3 *16 Aug 198417 Dec 1986Allied CorporationProsthetic devices
EP1482000A3 *13 Jul 199425 May 2005Eastman Chemical CompanyCopolyesters having repeat units derived from succinic acid
WO1995003347A1 *13 Jul 19942 Feb 1995Eastman Chemical CompanyCopolyesters having repeat units derived from succinic acid
WO1996022055A129 Dec 199525 Jul 1996Inbae YoonSurgical stapling system and method of applying staples from multiple staple cartridges
WO2004108792A2 *7 Apr 200416 Dec 2004Vinod Chintamani MalsheNovel biodegradable aliphatic polyesters and pharmaceutical compositions and applications thereof
WO2004108792A3 *7 Apr 200424 Mar 2005Padma Venkitachalam DevarajanNovel biodegradable aliphatic polyesters and pharmaceutical compositions and applications thereof
U.S. Classification128/898, 57/243, 528/279, 623/1.38, 528/285, 528/272, 606/231
International ClassificationA61L27/00, C08G63/16, A61L17/00, A61L17/14, C08G63/00, A61L17/10, A61L27/18
Cooperative ClassificationC08G63/16, A61L17/105, A61L17/145, A61L27/18
European ClassificationA61L27/18, C08G63/16, A61L17/10B, A61L17/14C