US3876771A - Skin protective gel containing polyvinyl methylether or monoisopropyl ester of polyvinyl methylether maleic acid - Google Patents

Skin protective gel containing polyvinyl methylether or monoisopropyl ester of polyvinyl methylether maleic acid Download PDF

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US3876771A
US3876771A US394061A US39406173A US3876771A US 3876771 A US3876771 A US 3876771A US 394061 A US394061 A US 394061A US 39406173 A US39406173 A US 39406173A US 3876771 A US3876771 A US 3876771A
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polyvinyl methylether
methylether
polyvinyl
skin
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US394061A
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Wilhelm G Denner
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Hallister Inc
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Hallister Inc
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Priority to US394061A priority Critical patent/US3876771A/en
Priority to CA207,297A priority patent/CA1054058A/en
Priority to GB3757474A priority patent/GB1453167A/en
Priority to DE2441627A priority patent/DE2441627C3/en
Priority to JP49099993A priority patent/JPS5220526B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/14—Adhesives for ostomy devices

Definitions

  • the Present mvemlo Provides a Protective 5km coat- [58] Field of Search 424/78, s0. 81, 362; ing material in the form of gel primarily intended for 252 31 use in combination with ostomy appliances and the like.
  • the gelatinous material is made up of a film- 5 References Cited forming protective colloidal materia] in combination UNITED STATES PATENTS with a solvent and a gelling agent.
  • the same technique may be employed and the operation in this instance is called an ileostomy.
  • the waste material discharged from the stoma is generally noncorrosive and appliances, often referred to as ostomy appliances, are employed to collect and retain the discharged waste material for subsequent disposal.
  • ostomy appliances are employed to collect and retain the discharged waste material for subsequent disposal.
  • the material discharged may still be incompletely digested and the discharge may include a significant amount of gastric juices which are still active and will attack the skin of the patient if allowed to come in contact therewith.
  • ostomy appliances are worn by the patient to collect the waste discharged from the ileostomy stoma, but care must be taken to effect a proper seal around the stoma not only to prevent soiling of the clothes of the wearer and the escape of unpleasant odors, problems common to both colostomy and ileostomy patients, but also to prevent the still active gastric juices from coming in contact with and damaging the skin.
  • a skin coating or skin protective material in the form of a gel.
  • the gel is sufficiently stiff as to be able to support itself in position without running, even when applied to the skin surface surrounding the stoma while the patient is standing.
  • the gel dries to a thin protective coating against which the adhesive or other sealing means of the ostomy appliance may be pressed, and the stress of subsequently removing the appliance is directed primarily against the coating material rather than directly against the skin.
  • the gel of the present invention comprises film formers in a solvent mixed with pre- 7 servatives and a gelling agent.
  • the preferred ingredients and their proportions are set forth below, and where available the trade name and manufacturer, as presently known, is also stated.
  • Polyvinyl methylether having an acid value (I) and being soluble in Trade Name Manufacturer Shell or Exxon Tenneco Hayden Div.
  • Lutonal M-40 BASF Wyandotte water and low boiling alcohols Modified polyacrylic acid having a molecular wt.
  • ostomy appliances have been provided with an adhesive face adapted to adhere to the skin surrounding the stoma, and in some cases have used a gum karaya seal such as the seal shown and described in US Pat. No. 3,302,647.
  • a bag or other container is provided in conjunction with the sealing means in order to collect the discharged waste.
  • the ostomy appliance which includes a ring-like member having an adhesive face on one side and a bag to receive the discharged material on the other.
  • the application and removal of the device often Carbopol 934 B.F. Goodrich Ethomeen C/ZS Armour Chem.
  • the isopropanol is, of course, the solvent, Gantrez ES 335 I is a film former, as are polyvinyl pyrrolidone K-30 and the Lutonal M-40.
  • the Carbopol 934 and the Klucel GF are the gelling agents, while the parasepts are the preservatives and the Ethomeen C/25 is neutralizing agent for the Carbopol 934.
  • Carbopol 934 is a water-soluble polyacrylic acid crosslinked with about 1% of polyallyl sucrose having an average of about 5.8 allyl groups for each sucrose molecule; US. Patent No. 3,133,865.
  • Gantrez ES 335 I has the following repeating unit Which is a clear viscous liquid with an acid number of 255-285, a specific gravity of 0.957 and a density (pounds/gallon) of 7.98.
  • the methyl and butyl parasepts are dissolved in isopropanol and the polyvinyl pyrrolidone K-30 is added under agitation.
  • the Carbopol 934 is added slowly while subjecting the mixture to high speed agitation. The agitation should be continued until it is certain that no lumps remain.
  • the mixture is then neutralized with Ethomeen C/25. This will form a thick gel.
  • a second solution is made comprising 25% Lutonal M-40 and 75% isopropyl alcohol. This Lutanol/isopropyl alcohol mixture is then added to the thick gel under rapid agitation, which agitation is continued until a homogenous mixture has been formed.
  • the resulting material will still be in gel form and can be packaged as desired for use.
  • upper limit and lower limit equalto percentage of Carbopol 934.
  • Ethomeen (/25 The isopropanol should, of course, be cosmetic grade.
  • the Klucel OP is added to the grams of isopropyl alcohol under high agitation. Continuing the agitation, the distilled water is added which will initially result in a granular appearing mixture, which will subsequently disappear during the mixing process.
  • the 10 grams of isopropanol is used to dissolve the sorbic acid and then the polyvinyl pyrrolidone is added thereto.
  • the Gantrez ES 335 I is then mixed into the isopropanol/sorbic acid/polyvinyl pyrrolidone mixture and thoroughly mixed therein.
  • the resulting mixture is then combined with the mixture first formed, and the two are thoroughly blended together. The result will be a gel of the desired viscosity and characteristics.
  • the gel formed in accordance with the formulation set forth may be applied without regard to the posture of the patient.
  • the gel will dry to a thin coating surrounding the stoma and will not only improve the adhesion of the appliance. but also serves to protect the skin of the user from irritation.
  • a gelatinous mixture for application to human skin comprising:
  • a preservative selected from the group consisting of sorbic acid, butyl parahydroxybenzoate and methyl parahydroxybenzoate,
  • a film forming agent selected from the group consisting of monoisopropyl ester of polyvinyl methylether and polyvinyl methylether, and
  • a gelling agent selected from the group consisting of hydroxypropyl cellulose and watersoluble polyacrylic acid crosslinked with 1% of polyallyl sucrose having an average of about 5.8 allyl groups for each sucrose molecule.
  • a gelatinous mixture for application to human skin comprising:
  • a preservative selected from the group consisting of sorbic acid, butyl parahydroxybenzoate and methyl parahydroxybenzoate.
  • a film forming agent selected from the group consisting of monoisopropyl ester of polyvinyl methylether and polyvinyl methylether,
  • a gelatinous mixture for application to human skin comprising:
  • a preservative selected from the group consisting of butyl parahydroxybenzoate and methyl parahydroxybenzoate 1.0 to 5% by weight of polyvinyl pyrrolidone,
  • a gelatinous mixture for application to human skin comprising:
  • a gelatinous mixture for application to human skin comprising:
  • a gelatinous mixture for application to human skin comprising:
  • Gantrez ES 335" should read Gantrez ES 335 I.

Abstract

The present invention provides a protective skin coating material in the form of a gel primarily intended for use in combination with ostomy appliances and the like. The gelatinous material is made up of a film-forming protective colloidal material in combination with a solvent and a gelling agent.

Description

United States Patent Denner 1 Apr. 8, 1975 [54] SKIN PROTECTIVE GEL CONTAINING 3,134,720 5/1964 Green et a1. 424/362 X POLYVINYL METHYLETHER 0 3.269.903 8/1966 Von Fieandt et al 424/81 3.485915 12/1969 Gerstein et a1. 424/81 MONOISOPROPYL ESTER OF POLYWNYL 3.632.547 1/1972 Kajioka, 424/80 x METHYLETHER MALE"? C D 3.710.779 1/1973 Bunnell et a1 424/80 x 75 Inventor: i G. a. Chicago 1". 3,749,773 7/1973 Nlnger et a]. 424/78 X [73] Assignee: Hallister Incorporated, Chicago. Ill. Primary E wm.ner stanly Friedman [22] Filed: Sept. 4, 1973 Assistant E.\'aminer--Vera C. Clarke Attorney, Agent, or Firm-Hofgren, Wegner, Allen, [2]] Appl 394361 Stellman & McCord [52] US. Cl. 424/78; 252/316; 424/80; 57 ABS-T A T 424/81; 424/362 1 e R [51] Int. Cl A61k 9/00 The Present mvemlo" Provides a Protective 5km coat- [58] Field of Search 424/78, s0. 81, 362; ing material in the form of gel primarily intended for 252 31 use in combination with ostomy appliances and the like. The gelatinous material is made up of a film- 5 References Cited forming protective colloidal materia] in combination UNITED STATES PATENTS with a solvent and a gelling agent.
2542897 2/1951 Brown et a1. 424/362 X 6 Claims, No Drawings SKIN PROTECTIVE GEL CONTAINING POLYVINYL METHYLETIIER OR MONOISOPROPYL ESTER OF I OLYVINYL METHYLETHER MALEIC ACID BACKGROUND OF'VTHE INVENTION Surgical correction of intestinal disorders is becoming a common practice. Where the colon is damaged or infected, a portion or even all of the large intestine may be removed (colostomy), and the new terminus of the intestinal tract is led out through an opening made in the abdominal wall to form a stoma. Where the disturbance is in the small intestine or extends into the small intestine, the same technique may be employed and the operation in this instance is called an ileostomy. In the case of a colostomy, the waste material discharged from the stoma is generally noncorrosive and appliances, often referred to as ostomy appliances, are employed to collect and retain the discharged waste material for subsequent disposal. In the case of an ileostomy, the material discharged may still be incompletely digested and the discharge may include a significant amount of gastric juices which are still active and will attack the skin of the patient if allowed to come in contact therewith. Again, ostomy appliances are worn by the patient to collect the waste discharged from the ileostomy stoma, but care must be taken to effect a proper seal around the stoma not only to prevent soiling of the clothes of the wearer and the escape of unpleasant odors, problems common to both colostomy and ileostomy patients, but also to prevent the still active gastric juices from coming in contact with and damaging the skin.
causes skin irritation even though there has been no contact with discharged waste material. Repeated applications of an adhesive device serves further to irritate the skin.
Attempts have been made in the past to remedy the situation described above by providing a skin coating material in the form of a liquid which may be applied to the skin by a sponge or other means. Because the liquid was extremely fluid, it was difficult to maintain the liquid in place until it had dried, and often the patient was required to lie on his back while applying the liquid and permitting the same to dry to form a protective coating. This provided a far from satisfactory solution.
BRIEF SUMMARY OF THE INVENTION In accordance with the present invention, there is provided a skin coating or skin protective material in the form of a gel. The gel is sufficiently stiff as to be able to support itself in position without running, even when applied to the skin surface surrounding the stoma while the patient is standing. The gel dries to a thin protective coating against which the adhesive or other sealing means of the ostomy appliance may be pressed, and the stress of subsequently removing the appliance is directed primarily against the coating material rather than directly against the skin.
DETAILED DESCRIPTION OF THE INVENTION As previously indicated, the gel of the present invention comprises film formers in a solvent mixed with pre- 7 servatives and a gelling agent. The preferred ingredients and their proportions are set forth below, and where available the trade name and manufacturer, as presently known, is also stated.
Chemical Name Isopropanol(70%) Methyl para-hydroxybenzoate Butyl para-hydroxybenzoate Polyvinyl pyrrolidone having a molecular wt.
Polyvinyl methylether having an acid value (I) and being soluble in Trade Name Manufacturer Shell or Exxon Tenneco Hayden Div.
GAF
Lutonal M-40 BASF Wyandotte water and low boiling alcohols Modified polyacrylic acid having a molecular wt.
Polyoxyethylene cocoamine having l5 oxy groups Monoisopropyl ester polyvinyl methylether/maleic acid 2,4 Hexadienoic acid Hydroxypropyl cellulose having a molecular wt.
As a consequence of the foregoing, ostomy appliances have been provided with an adhesive face adapted to adhere to the skin surrounding the stoma, and in some cases have used a gum karaya seal such as the seal shown and described in US Pat. No. 3,302,647. In all cases, a bag or other container is provided in conjunction with the sealing means in order to collect the discharged waste.
In the case of the ostomy appliance, which includes a ring-like member having an adhesive face on one side and a bag to receive the discharged material on the other. the application and removal of the device often Carbopol 934 B.F. Goodrich Ethomeen C/ZS Armour Chem.
Gantrez ES 335 GAF Sorbic acid Pfizer Chem Co. Klucel GF Hercules Inc.
Of the ingredients set forth above, the isopropanol is, of course, the solvent, Gantrez ES 335 I is a film former, as are polyvinyl pyrrolidone K-30 and the Lutonal M-40. The Carbopol 934 and the Klucel GF are the gelling agents, while the parasepts are the preservatives and the Ethomeen C/25 is neutralizing agent for the Carbopol 934.
Carbopol 934 is a water-soluble polyacrylic acid crosslinked with about 1% of polyallyl sucrose having an average of about 5.8 allyl groups for each sucrose molecule; US. Patent No. 3,133,865. Gantrez ES 335 I has the following repeating unit Which is a clear viscous liquid with an acid number of 255-285, a specific gravity of 0.957 and a density (pounds/gallon) of 7.98.
An example of the preparation and the method of mixing the same is as follows:
In forming the gel, the methyl and butyl parasepts are dissolved in isopropanol and the polyvinyl pyrrolidone K-30 is added under agitation. When completely dissolved, the Carbopol 934 is added slowly while subjecting the mixture to high speed agitation. The agitation should be continued until it is certain that no lumps remain. The mixture is then neutralized with Ethomeen C/25. This will form a thick gel. A second solution is made comprising 25% Lutonal M-40 and 75% isopropyl alcohol. This Lutanol/isopropyl alcohol mixture is then added to the thick gel under rapid agitation, which agitation is continued until a homogenous mixture has been formed. The resulting material will still be in gel form and can be packaged as desired for use.
The proportion of ingredients set forth above may be varied and still result in a gel usable for the purposes intended. The upper and lower limits of the ingredients are set forth below.
Ingredient Upper Limit Lower Limit lsopropanol 8071 50% Methyl and hutyl parasepts 57: 1% Lutonal M-40 50% 5% Polyvinyl pyrrolidone K-30 5% 1% Carbopol 934 5'7: 1%
upper limit and lower limit equalto percentage of Carbopol 934.
Ethomeen (/25 The isopropanol should, of course, be cosmetic grade.
in mixing the ingredients for the example set forth just above, the Klucel OP is added to the grams of isopropyl alcohol under high agitation. Continuing the agitation, the distilled water is added which will initially result in a granular appearing mixture, which will subsequently disappear during the mixing process.
The 10 grams of isopropanol is used to dissolve the sorbic acid and then the polyvinyl pyrrolidone is added thereto. The Gantrez ES 335 I is then mixed into the isopropanol/sorbic acid/polyvinyl pyrrolidone mixture and thoroughly mixed therein. The resulting mixture is then combined with the mixture first formed, and the two are thoroughly blended together. The result will be a gel of the desired viscosity and characteristics.
The upper and lower limits of the ingredients in Example 2 are set forth below.
plus what additional isopropanol CO is required to dissolve the polyvinyl pyrrolidone to form the second mixture described above.
As previously indicated, the gel formed in accordance with the formulation set forth may be applied without regard to the posture of the patient. The gel will dry to a thin coating surrounding the stoma and will not only improve the adhesion of the appliance. but also serves to protect the skin of the user from irritation.
1 claim:
1. A gelatinous mixture for application to human skin, comprising:
25 to by weight of isopropanol,
0.1 to 5% by weight of a preservative selected from the group consisting of sorbic acid, butyl parahydroxybenzoate and methyl parahydroxybenzoate,
O to 50% by weight of polyvinyl pyrrolidone,
5 to 50% by weight of a film forming agent selected from the group consisting of monoisopropyl ester of polyvinyl methylether and polyvinyl methylether, and
1.5 to 5% by weight of a gelling agent selected from the group consisting of hydroxypropyl cellulose and watersoluble polyacrylic acid crosslinked with 1% of polyallyl sucrose having an average of about 5.8 allyl groups for each sucrose molecule.
2. A gelatinous mixture for application to human skin, comprising:
25 to 90% by weight of isopropanol,
0.1 to 5% by weight of a preservative selected from the group consisting of sorbic acid, butyl parahydroxybenzoate and methyl parahydroxybenzoate.
0 to 5% by weight of polyvinyl pyrrolidone.
5 to 50% by weight of a film forming agent selected from the group consisting of monoisopropyl ester of polyvinyl methylether and polyvinyl methylether,
1.96 to 3% by weight of water-soluble polyacrylic acid crosslinked with l% of polyallyl sucrose having an average of about 5.8 allyl groups for each sucrose molecule.
2 to 3% by weight of polyoxyethylene cocoamine 5 having oxy groups.
3. A gelatinous mixture for application to human skin, comprising:
63 to 80% by weight of isopropanol,
0.l to 5% by weight of a preservative selected from the group consisting of butyl parahydroxybenzoate and methyl parahydroxybenzoate 1.0 to 5% by weight of polyvinyl pyrrolidone,
31 to 50% by weight of polyvinyl methylether,
2 to 3% by weight of water-soluble polyacrylic acid crosslinked with 1% of polyallyl sucrose having an average of about 5.8 allyl groups for each sucrose molecule, and
2.0 to 3% by weight of polyoxyethylene having 15 oxy groups cocoamine.
4. A gelatinous mixture for application to human skin, comprising:
5 to 45% by weight of monoisopropyl ester of polyvinyl methylether, and
2 to 10% by weight of hydroxypropyl cellulose.
5. A gelatinous mixture for application to human skin, comprising:
63% by weight of isopropanol,
less than 5% by weight of methyl parahydroxybenzoate and butyl para-hydroxybenzoate 1.0% by weight of polyvinyl pyrrolidone,
31% by weight of polyvinyl methylether,
2% by weight of water-soluble polyacrylic acid crosslinked with 1% of polyallyl sucrose having an average of about 5.8 allyl groups for each sucrose molecule, and
2% by weight of polyoxyethylene cocoamine having 15 oxy groups.
6. A gelatinous mixture for application to human skin, comprising:
% by weight of isopropylalcohol,
less than 0.4% by weight of sorbic acid,
1% by weight of polyvinyl pyrrolidone,
5% by weight of distilled water,
5% by weight of hydroxypropyl cellulose, and
9% by weight of monoisopropyl ester of polyvinyl methylether.
UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION PATENT NO. 3,876,771 DATED 2 April 8, 1975 INVENTOR( 1 Wilhelm G. Denner it is certified that error appears in the above-identified patent and that said Letters Patent are hereby corrected as shown beiow:
In the title, change "METHYLETHER MALEIC ACID" to METHYLETHER/MALEIC ACID The name of the assignee is HOLLIS'IER INCORPORATED.
Column 2, near the bottom of the table, the trade name "Gantrez ES 335" should read Gantrez ES 335 I.
Column 3, in the penultimate line of Example 2 "6771" should be deleted.
Signed and gealed this [SEAL] A ttes t:
C. MARSHALL DANN Commissioner of Parents and Trademarks RUTH C. MASON Arresting 0mm

Claims (1)

1. A GELATINOUS MIXTURE FOR APPLICATION TO HUMAN SKIN, COMPRISING: 25 TO 90% BY WEIGHT OF ISOPRANOL, 0.1 TO 5% BY WEIGHT OF A PRESERVATIVE SELECTED FROM THE GROUP CONSISTING OS SORBIC ACID, BUTYL PARAHYDROXYBENZOATE AND METHYL PARA-HYDROXYBENZOATE, 0 TO 50% BY WEIGHT OF POLYVINYL PYRROLIDONE, 5 TO 50% BY WEIGHT OF A FILM FORMING AGENT SELECTED FROM THE GROUP CONSISTING OF MONOISOPROPYL ESTER OF POLYVINYL METHYLETHER AND POLYVINYL METHYLETHER, AND 1.5 TO 5% BY WEIGHT OF A GELLING AGENT SELECTED FROM THE GROUP CONSISTING OF HYDROXYPROPYL CELLULOSE AND WATERSOLUBLE POLYACRYLIC ACID CROSSLINKED WITH 1% OF POLYALLYL SUCROSE HAVING AN AVERAGE OF ABOUT 5.8 ALLYL GROUPS FOR EACH SUCROSE MOLECULE.
US394061A 1973-09-04 1973-09-04 Skin protective gel containing polyvinyl methylether or monoisopropyl ester of polyvinyl methylether maleic acid Expired - Lifetime US3876771A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US394061A US3876771A (en) 1973-09-04 1973-09-04 Skin protective gel containing polyvinyl methylether or monoisopropyl ester of polyvinyl methylether maleic acid
CA207,297A CA1054058A (en) 1973-09-04 1974-08-19 Skin protective gel used in conjunction with ostomy appliances
GB3757474A GB1453167A (en) 1973-09-04 1974-08-28 Skin protective gel
DE2441627A DE2441627C3 (en) 1973-09-04 1974-08-30 Skin protection gel
JP49099993A JPS5220526B2 (en) 1973-09-04 1974-09-02

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US394061A US3876771A (en) 1973-09-04 1973-09-04 Skin protective gel containing polyvinyl methylether or monoisopropyl ester of polyvinyl methylether maleic acid

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US3876771A true US3876771A (en) 1975-04-08

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JP (1) JPS5220526B2 (en)
CA (1) CA1054058A (en)
DE (1) DE2441627C3 (en)
GB (1) GB1453167A (en)

Cited By (17)

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Publication number Priority date Publication date Assignee Title
US4140656A (en) * 1977-10-07 1979-02-20 Armour-Dial, Inc. Anhydrous clear gel facial cleanser
FR2448555A1 (en) * 1979-02-08 1980-09-05 Matburn Holdings Ltd POLYMERIC COMPOSITION, PROTECTIVE DRESSING AND SEALING RING FOR A POST-SURGICAL DRAINAGE DEVICE FORMED THEREFROM
US4309414A (en) * 1978-06-17 1982-01-05 Kowa Company Limited Antiinflammatory analgesic gelled ointment
EP0048556A1 (en) * 1980-09-12 1982-03-31 E.R. Squibb & Sons, Inc. Hydrocolloid containing paste-like composition
US4364929A (en) * 1979-04-02 1982-12-21 The Purdue Frederick Company Germicidal colloidal lubricating gels and method of producing the same
US4393080A (en) * 1981-12-24 1983-07-12 E. R. Squibb & Sons, Inc. Adhesive compositions
US4503034A (en) * 1982-09-07 1985-03-05 Laboratoires Biotrol S.A Paste for protecting the skin
US4680323A (en) * 1983-12-01 1987-07-14 Hans Lowey Method and composition for the preparation of controlled long-acting pharmaceuticals for oral administration
WO1992009289A1 (en) * 1990-11-27 1992-06-11 Biolab Pharmaceuticals, Inc. Diaper rash treatment
US5194261A (en) * 1990-11-27 1993-03-16 Virgil Pichierri Diaper rash treatment
US5320838A (en) * 1992-12-21 1994-06-14 Pro Cure Products, Ltd. Protectant for irritated skin containing polyethyleneglycols, polyvinylether salt anhydride and polyvinylpyrrolidone
US6123958A (en) * 1991-09-10 2000-09-26 Johnson & Johnson Medical, Inc. Web dressing and method for its production
US6312415B1 (en) 1997-05-26 2001-11-06 Coloplast A/S Ostomy appliance
US6332879B1 (en) 1997-05-26 2001-12-25 Coloplast A/S Ostomy appliance
US20030223950A1 (en) * 2002-05-02 2003-12-04 Michael Lede Water-free hairstyling gels
US20040054015A1 (en) * 1994-03-21 2004-03-18 Thomsen John Brown Gel for treatment of skin diseases
US20040126345A1 (en) * 2002-12-27 2004-07-01 Mcnamara William E. Post-foaming cosmetic composition and method employing same

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US2542897A (en) * 1945-10-12 1951-02-20 Brown Ethan Allan Antiseptic wound dressings
US3134720A (en) * 1962-06-27 1964-05-26 Bristol Myers Co Medicated gels
US3269903A (en) * 1956-02-24 1966-08-30 Bofors Ab Liquid plastic dressing which absorbs ultraviolet light
US3485915A (en) * 1966-04-22 1969-12-23 Revlon Thickened hydroxypropyl cellulose compositions
US3632547A (en) * 1969-07-02 1972-01-04 Synergistic Ind Inc Textile adhesive and method of use
US3710779A (en) * 1970-01-16 1973-01-16 Hoffmann La Roche Method of ultrasonic coupling
US3749773A (en) * 1971-02-25 1973-07-31 Warner Lambert Co Gelled steroid ointment

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2542897A (en) * 1945-10-12 1951-02-20 Brown Ethan Allan Antiseptic wound dressings
US3269903A (en) * 1956-02-24 1966-08-30 Bofors Ab Liquid plastic dressing which absorbs ultraviolet light
US3134720A (en) * 1962-06-27 1964-05-26 Bristol Myers Co Medicated gels
US3485915A (en) * 1966-04-22 1969-12-23 Revlon Thickened hydroxypropyl cellulose compositions
US3632547A (en) * 1969-07-02 1972-01-04 Synergistic Ind Inc Textile adhesive and method of use
US3710779A (en) * 1970-01-16 1973-01-16 Hoffmann La Roche Method of ultrasonic coupling
US3749773A (en) * 1971-02-25 1973-07-31 Warner Lambert Co Gelled steroid ointment

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140656A (en) * 1977-10-07 1979-02-20 Armour-Dial, Inc. Anhydrous clear gel facial cleanser
US4309414A (en) * 1978-06-17 1982-01-05 Kowa Company Limited Antiinflammatory analgesic gelled ointment
FR2448555A1 (en) * 1979-02-08 1980-09-05 Matburn Holdings Ltd POLYMERIC COMPOSITION, PROTECTIVE DRESSING AND SEALING RING FOR A POST-SURGICAL DRAINAGE DEVICE FORMED THEREFROM
US4364929A (en) * 1979-04-02 1982-12-21 The Purdue Frederick Company Germicidal colloidal lubricating gels and method of producing the same
EP0048556A1 (en) * 1980-09-12 1982-03-31 E.R. Squibb & Sons, Inc. Hydrocolloid containing paste-like composition
US4393080A (en) * 1981-12-24 1983-07-12 E. R. Squibb & Sons, Inc. Adhesive compositions
US4503034A (en) * 1982-09-07 1985-03-05 Laboratoires Biotrol S.A Paste for protecting the skin
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US7837985B2 (en) 2002-12-27 2010-11-23 Avon Products, Inc Post application expanding cosmetic composition and method employing same
US7837984B2 (en) 2002-12-27 2010-11-23 Avon Products, Inc. Post-foaming cosmetic composition and method employing same
US7846424B2 (en) 2002-12-27 2010-12-07 Avon Products, Inc Non-pressurized post-application expanding composition

Also Published As

Publication number Publication date
JPS5052232A (en) 1975-05-09
JPS5220526B2 (en) 1977-06-04
CA1054058A (en) 1979-05-08
DE2441627C3 (en) 1980-05-22
DE2441627B2 (en) 1979-08-30
DE2441627A1 (en) 1975-03-13
GB1453167A (en) 1976-10-20

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