US3817389A - Filter device in tubular fitting for medical injection equipment and the like - Google Patents

Filter device in tubular fitting for medical injection equipment and the like Download PDF

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Publication number
US3817389A
US3817389A US32372673A US3817389A US 3817389 A US3817389 A US 3817389A US 32372673 A US32372673 A US 32372673A US 3817389 A US3817389 A US 3817389A
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Prior art keywords
filter
peripheral wall
annular projection
fitting
filter device
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T Weichselbaum
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Sherwood Medical Co
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Sherwood Medical Industries Inc
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Priority to US05323726 priority Critical patent/US3817389A/en
Priority to AU61263/73A priority patent/AU485504B2/en
Priority to JP11977773A priority patent/JPS49103487A/ja
Priority to CA189,405A priority patent/CA1032878A/en
Priority to BE139594A priority patent/BE809478A/en
Priority to FR7401000A priority patent/FR2324316A1/en
Priority to DE2401782A priority patent/DE2401782C2/en
Priority to GB5907373A priority patent/GB1462780A/en
Priority to US05/438,298 priority patent/US3976529A/en
Application granted granted Critical
Publication of US3817389A publication Critical patent/US3817389A/en
Assigned to SHERWOOD MEDICAL COMPANY reassignment SHERWOOD MEDICAL COMPANY MERGER (SEE DOCUMENT FOR DETAILS). Assignors: SHERWOOD MEDICAL INDUSTRIES INC. (INTO)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3145—Filters incorporated in syringes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D35/00—Filtering devices having features not specifically covered by groups B01D24/00 - B01D33/00, or for applications not specifically covered by groups B01D24/00 - B01D33/00; Auxiliary devices for filtration; Filter housing constructions
    • B01D35/18—Heating or cooling the filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/02—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor by heating, with or without pressure
    • B29C65/44—Joining a heated non plastics element to a plastics element
    • B29C65/46—Joining a heated non plastics element to a plastics element heated by induction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C65/00—Joining or sealing of preformed parts, e.g. welding of plastics materials; Apparatus therefor
    • B29C65/78—Means for handling the parts to be joined, e.g. for making containers or hollow articles, e.g. means for handling sheets, plates, web-like materials, tubular articles, hollow articles or elements to be joined therewith; Means for discharging the joined articles from the joining apparatus
    • B29C65/7841—Holding or clamping means for handling purposes
    • B29C65/7847—Holding or clamping means for handling purposes using vacuum to hold at least one of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/61—Joining from or joining on the inside
    • B29C66/612—Making circumferential joints
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/73—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/739—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset
    • B29C66/7392—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the intensive physical properties of the material of the parts to be joined, by the optical properties of the material of the parts to be joined, by the extensive physical properties of the parts to be joined, by the state of the material of the parts to be joined or by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of the parts to be joined being a thermoplastic or a thermoset characterised by the material of at least one of the parts being a thermoplastic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/80—General aspects of machine operations or constructions and parts thereof
    • B29C66/83—General aspects of machine operations or constructions and parts thereof characterised by the movement of the joining or pressing tools
    • B29C66/832—Reciprocating joining or pressing tools
    • B29C66/8322—Joining or pressing tools reciprocating along one axis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/165—Filtering accessories, e.g. blood filters, filters for infusion liquids
    • A61M2005/1652—Filter with duct, e.g. filtering element incorporated in a flow line, tube, duct
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/50—General aspects of joining tubular articles; General aspects of joining long products, i.e. bars or profiled elements; General aspects of joining single elements to tubular articles, hollow articles or bars; General aspects of joining several hollow-preforms to form hollow or tubular articles
    • B29C66/51—Joining tubular articles, profiled elements or bars; Joining single elements to tubular articles, hollow articles or bars; Joining several hollow-preforms to form hollow or tubular articles
    • B29C66/53—Joining single elements to tubular articles, hollow articles or bars
    • B29C66/534—Joining single elements to open ends of tubular or hollow articles or to the ends of bars
    • B29C66/5344—Joining single elements to open ends of tubular or hollow articles or to the ends of bars said single elements being substantially annular, i.e. of finite length, e.g. joining flanges to tube ends
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/71—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material characterised by the composition of the plastics material of the parts to be joined
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C66/00—General aspects of processes or apparatus for joining preformed parts
    • B29C66/70—General aspects of processes or apparatus for joining preformed parts characterised by the composition, physical properties or the structure of the material of the parts to be joined; Joining with non-plastics material
    • B29C66/74—Joining plastics material to non-plastics material
    • B29C66/742—Joining plastics material to non-plastics material to metals or their alloys
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/14—Filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/753—Medical equipment; Accessories therefor
    • B29L2031/7544—Injection needles, syringes

Definitions

  • parenteral solutions as used throughout this patent is intended to refer to any solution intravenously or intramuscularly fed to a patient, including medication injected by a hypodermic syringe and various solutions (e.g., glucose, blood, medication, et cetera) fed intravenously through an intravenous infusion set.
  • solutions e.g., glucose, blood, medication, et cetera
  • parenteral solutions are often contaminated by particulate matter from the infusion equipment, e. g., the glass or plastic container for the solution, the tubing set, the stopper or bung and other accessories of the equipment. Obviously such contamination may be harmful to the patient, depending on the type, size, quantity, etc., of the contaminating particles. Harmful effects have been demonstrated by medical researchers by means of human autopsies and studies on various animals.
  • Particulate contamination is also present in the parenteral solutions injected into patients by means of hypodermic syringes.
  • Sources of such contamination in clude the syringe barrels, plungers (which typically have rubber tips) and the covers (typically rubber) and interior (typically glass) of multi-dose vials from which solutions to be injected are withdrawn.
  • filters be employed in injection equipment to filter particulate contamination from parenteral fluids fed to patients.
  • no filters or filter devices heretofore designed have met with any appreciable acceptance or use in the medical field because none of these prior filter devices have satisfied various requirements that any filter employed in conjunction with medical injection equipment must meet.
  • One such requirement is that the filter element must be effectively sealed or bonded in the fluid flow line of the injection or infusion equipment to insure that the filter performs its intended function effectively and efficiently.
  • a second requirement is that the filter device and means of incorporation into the injection or infusion equipment not add appreciably to the cost of the equipment, particularly in view of the fact that most of the injection and infusion equipment in use today is disposable (i.e., designed to be discarded after a single use).
  • a third important requirement is that the filter must be compatible with the shape, size and operation of existing injection and infusion eqiupment.
  • the filter device of the present invention .and the method of making the device satisfy the efficiency, cost and compatibility requirements discussed above, and provide other advantages which will become apparent from a review of the filter device and method of the present invention as shown in the drawings and described in the following specification and claims.
  • FIG. I is an exploded perspective view of a hypodermic needle into which a filter device of the present invention may be incorporated.
  • FIG. 2 is a sectional elevation view of the hub or tubular fitting of the apparatus shown in FIG. l with a filter element of the present invention being inserted therein.
  • FIG. 3 is a sectional elevation view similar to FIG. 2 showing the filter in place in the fitting.
  • FIG. 4 is a sectional elevation view similar to FIGS. 2 and 3 showing the filter being induction heated to seal it in the fitting.
  • FIG. 5 is a partial sectional elevation view showing in greater detail the seal between the filter and the fitting.
  • FIG. 1 illustrates a hypodermic needle 10 into which the filter device of the present invention may be incor porated.
  • the needle 10 includes a needle cannula 12 (preferably stainless steel) connected to the forward or distal end of a thermoplastic tubular hub or fitting 16 having a porous, sintered, powdered metal filter element 18 therein.
  • the hypodermic needle 10 of FIG. 1 is only an exemplary showing of a medical injection device into which the filter device of the present invention may be incorporated. It iscontemplated that the filter device of the present invention may be incorporated in various types of medical equipment and the like, including intravenous infusion sets, hypodermic syringes and double luer adapters.
  • the tubular thermoplastic fitting or connector 16 is exemplary of only one of numerous types of connectors, fittings, adaptors and hubs into which a filter may be incorporated and sealed to form the filter device of the present invention.
  • the structure of the filter device of the present invention and the method by which the porous metal filter 18 is sealed into the tubular thermoplastic connector 16 to form a filter device of the present invention may best be understood by referring to FIGS. 2 to 5.
  • the thermoplastic connector 16 is of generally tubular shape and has internal peripheral wall 19 defining a longitudinal passage 20 extending therethrough.
  • the outer or proximal end 22 of the passage 20 is tapered outwardly (commonly referred to in the medical field as a female luer taper) to facilitate sealing reception of the tip of a syringe (or other tubular member) to which the proximal end of the fitting 16 is to be connected.
  • the forward or distal end of the passage through the stem 24 may be cylindrical or tapered to receive the butt end of the needle cannula 12, which may, for example, be epoxy bonded therein.
  • the intermediate portion of the peripheral wall 19 of passage 20 is provided with a shoulder 30 which functions as a seat for the end of the filter 18.
  • An inwardlyprojecting annular ring or bead 32 is provided on the interior wall 19 of the fitting 16 just above the shoulder or seat 30.
  • the internal diameter of the bead 32 is slightly less than the outer diameter of the filter 18 so that the end of the filter 18 can be force-fit into the bead 32 in a manner and for a purpose described more fully below.
  • thermoplastic as used herein, is intended to refer to any plastic material that will soften when heated and re-solidify or harden when cooled.
  • the thermoplastic fitting or connector 16 is preferably constructed of a relatively rigid thermoplastic such as polypropylene, polycarbonate or polyethylene terephthalate.
  • the filter 18 is preferably cylindrical cup-shaped in form, having a closed rear end 36 and an open forward end 38 defined by a forward peripheral wall 39.
  • the filter 18 is preferably formed of a porous, sintered, powdered stainless steel.
  • the particular formation and interrelationship of the particles of the filter 18 are important, but do not constitute a part of the invention of this patent.
  • the composition of the filter 18 may be of the type described in copending application Ser. No. 354,309, filed Apr. 25, 1973.
  • the filter element 18 is positioned and sealed or bonded in the tubular fitting 16 in the following manner.
  • the filter element 18 is inserted, open end first, into the passage 20 of the fitting 16 by means of a suitable tool, such as the insertion tip 40 of a suitable vacuum tool, as shown in FIG. 2.
  • a suitable tool such as the insertion tip 40 of a suitable vacuum tool, as shown in FIG. 2.
  • the filter element 18 is held on the tool 40 by suction, and is pressed downwardly through the plastic annular ring or bead 32 until the forward peripheral wall 39 of the open forward end 38 rests or seats on the annular shoulder 30.
  • the outer diameter of the filter element 18 is slightly larger than the internal diameter of the annular bead 32 so that the forward end of the filter 18 is forcefit in the annular bead 32 to compress and deform the bead (see FIG. 3).
  • the filter element 18 With the filter element 18 in place (i.e., with the forward end wall 39 of the filter abutting the shoulder 30 in the fitting l6 and the forward end portion of the peripheral wall of the filter l8 force-fit in the annular bead 32), the filter element 18 is heated to a temperature and for such a time to heat the thermoplastic bead 32, which melts or softens and flows into the pores in a continuous ring around the forward end portion of the outer peripheral wall of the filter element 18. As shown in FIG. 4, it is contemplated that the filter element 18 may be heated by the electromagnetic field generated by induction heating coils 44. It is contemplated, however, that other means of heating the filter element 18 may be employed so long as such heating means does not interfere with the compressive force exerted by the filter element on the annular bead 32.
  • FIG. is an enlarged sectional view illustrating the intrusion of the plastic bead 32 into the pores around the outer peripheral wall of the forward end portion of the filter element 18 after the bead has cooled and resolidified.
  • the seal or bond formed between the bead 32 and the forward end portion of the outer surface of filter element 18 is a relatively thin continuous ring which does not significantly reduce the effective surface area of the filter which is exposed to the solution to be filtered.
  • the seal will not inhibit the flow rate of the solution which must pass through the 6 LII element 18 at a maximum to insure that the flow rate of the solution passed through the filter may be maintained at the desired level.
  • the cylindrical cup shape of the filter element 18 maximizes the effective surface area of the filter which is exposed to the solution to be passed therethrough, consistant with the over-all size limitations imposed by the fitting into which it is inserted, to maximize the permissible flow rate of the solution.
  • the method of the present invention provides a filter device for medical injection equipment and the like which is relatively inexpensive, efficient and readily adaptable for use with existing injection and infusion equipment (e.g., plastic fittings, such as injection needle hubs).
  • existing injection and infusion equipment e.g., plastic fittings, such as injection needle hubs.
  • the ring seal or bond formed between the tubular fitting and the peripheral wall of the filter provides an effective continuous seal which does not interfere with the critical, permissible flow rate of solution through the filter, yet insures a fluid tight seal to prevent fluid from passing around, rather than through, the filter element.
  • the method and resulting filter device of the present invention satisfies the existing need in the industry for a device which will effectively eliminate or minimize particulate contamination in parenteral fluids to be injected into patients.
  • a filter device for medical infusion and injection equipment and the like comprising:
  • a generally cylindrical, cup-shaped, porous, sintered powdered metal filter element having an open distal end and a closed proximal end;
  • tubular, thermoplastic fitting having a longitudinal passage extending axially therethrough; a radiallyinwardly projecting annulus on the internal peripheral wall of said longitudinal passage; means defining a radially inwardly projecting seat on the internal peripheral wall of said longitudinal passage;
  • said filter element having a peripheral edge at said open distal end thereof; said peripheral edge of said filter element being disposed on and in contact with said seat of said fitting; said radially inwardly projecting annulus on the internal peripheral wall on said longitudinal passage having been softened and forced into pores of said filter element along a continuous peripheral ring adjacent to said peripheral edge of said open distal end of said filter element.
  • a filter device for medical infusion and injection equipment and the like comprising: a tubular member formed of relatively rigid thermoplastic, said tubular member having an internal annular projection therein; a sintered, porous, powdered metal filter having an end 3.
  • the filter device of claim 2 wherein said filter is made from stainless steel particles.
  • said thermoplastic is a polycarbonate.
  • thermoplastic is a polyethylene terephthalate.
  • thermoplastic is a polypropylene
  • a filter device for use as a part of an apparatus for the infusion or injection of parenteral fluid comprising:
  • a fitting formed of relatively rigid thermoplastic having an interior peripheral wall defining a passage therethrough; an annular projection on said interior wall; and a shoulder on said interior wall; said shoulder being spaced from said projection;
  • a sintered, porous, powdered stainless steel tubular filter having a closed end and a continuous peripheral wall extending from said end and adapted for a force fit into said annular projection and to abut said shoulder in said fitting;
  • said annular projection and said peripheral wall of said filter being in leakproof relation as a result of said filter and said annular projection having been heated to a temperature such that a portion of said projection flowed into pores of said peripheral wall and the subsequent cooling of said filter and said projection.

Abstract

A cylindrical, cup-shaped, porous, sintered powdered metal filter is sealed in a tubular thermoplastic fitting (e.g., the needle-retaining hub of a hypodermic needle or an adaptor or a connector in the line of an intravenous infusion set) by forcefitting the open end of the filter within an annular bead on the interior wall of the tubular fitting and induction heating the filter so that the thermoplastic bead will flow into the pores of the filter to form a continuous ring seal between the filter and the interior wall of the fitting.

Description

United States Patent 1191 [1 1] 3317,39 Weichselbaum [45] June 13 197 [5 FILTER DEVICE IN TUBULAR FITTING 3,121,685 2/1964 Hazel] 210/496 x FOR MED INJECTION EQUIPMENT 3,722,697 3/1973 Burke et al.. AND THE LIKE 3,753,500 8/1973 Voegeli 210/496 x Inventor: Theodore E. Weichselbaum,
Normandy, Mo.
Sherwood Medical Industries, Inc., St. Louis, Mo.
Filed: Jan. 15, 1973 Appl. No.: 323,726
Assignee:
US. Cl 210/448, 128/214 C, 210/452, 210/457, 210/496 Int. Cl 801d 35/00 Field of Search..... 128/214 B, 214 C; 210/446, 210/448, 451, 452, 457, 496
References Cited UNITED STATES PATENTS l2/1959 .laffe 210/451 X Primary ExaminerSamih N. Zahama Assistant ExaminerRjchard W. Burks Attorney, Agent, or Firm--Kendrick & Subkow [571 ABSTRACT 7 Claims, 5 Drawing Figures FILTER DEVICE IN TUBULAR FITTING FOR MEDICAL INJECTION EQUIPMENT AND THE LIKE The present invention relates generally to medical equipment and, more specifically, to filter devices for use in medical injection equipment such as hypodermic needles and intravenous infusion sets.
In recent years medical researchers have been expressing increasing concern about the presence of particulate contamination in parenteral solutions intravascularly infused or injected into patients, and about the possible harm such contamination may cause. The term parenteral solutions as used throughout this patent is intended to refer to any solution intravenously or intramuscularly fed to a patient, including medication injected by a hypodermic syringe and various solutions (e.g., glucose, blood, medication, et cetera) fed intravenously through an intravenous infusion set.
It is estimated that the average hospital patient currently receives approximately 2.5 liters of parenteral solutions during his illness, and the critically ill patient may receive as much as 100 liters or more. Recent studies have shown that the parenteral solutions are often contaminated by particulate matter from the infusion equipment, e. g., the glass or plastic container for the solution, the tubing set, the stopper or bung and other accessories of the equipment. Obviously such contamination may be harmful to the patient, depending on the type, size, quantity, etc., of the contaminating particles. Harmful effects have been demonstrated by medical researchers by means of human autopsies and studies on various animals.
Particulate contamination is also present in the parenteral solutions injected into patients by means of hypodermic syringes. Sources of such contamination in clude the syringe barrels, plungers (which typically have rubber tips) and the covers (typically rubber) and interior (typically glass) of multi-dose vials from which solutions to be injected are withdrawn.
It is thus apparent that there is a need in the medical field for some means to prevent or minimize particulate matter contamination in parenteral solutions.
It has been suggested that filters be employed in injection equipment to filter particulate contamination from parenteral fluids fed to patients. However, no filters or filter devices heretofore designed have met with any appreciable acceptance or use in the medical field because none of these prior filter devices have satisfied various requirements that any filter employed in conjunction with medical injection equipment must meet. One such requirement is that the filter element must be effectively sealed or bonded in the fluid flow line of the injection or infusion equipment to insure that the filter performs its intended function effectively and efficiently.
A second requirement is that the filter device and means of incorporation into the injection or infusion equipment not add appreciably to the cost of the equipment, particularly in view of the fact that most of the injection and infusion equipment in use today is disposable (i.e., designed to be discarded after a single use).
A third important requirement is that the filter must be compatible with the shape, size and operation of existing injection and infusion eqiupment.
The filter device of the present invention, .and the method of making the device satisfy the efficiency, cost and compatibility requirements discussed above, and provide other advantages which will become apparent from a review of the filter device and method of the present invention as shown in the drawings and described in the following specification and claims.
In the drawings:
FIG. I is an exploded perspective view of a hypodermic needle into which a filter device of the present invention may be incorporated.
FIG. 2 is a sectional elevation view of the hub or tubular fitting of the apparatus shown in FIG. l with a filter element of the present invention being inserted therein.
FIG. 3 is a sectional elevation view similar to FIG. 2 showing the filter in place in the fitting.
FIG. 4 is a sectional elevation view similar to FIGS. 2 and 3 showing the filter being induction heated to seal it in the fitting.
FIG. 5 is a partial sectional elevation view showing in greater detail the seal between the filter and the fitting.
FIG. 1 illustrates a hypodermic needle 10 into which the filter device of the present invention may be incor porated. The needle 10 includes a needle cannula 12 (preferably stainless steel) connected to the forward or distal end of a thermoplastic tubular hub or fitting 16 having a porous, sintered, powdered metal filter element 18 therein. The hypodermic needle 10 of FIG. 1 is only an exemplary showing of a medical injection device into which the filter device of the present invention may be incorporated. It iscontemplated that the filter device of the present invention may be incorporated in various types of medical equipment and the like, including intravenous infusion sets, hypodermic syringes and double luer adapters. The tubular thermoplastic fitting or connector 16 is exemplary of only one of numerous types of connectors, fittings, adaptors and hubs into which a filter may be incorporated and sealed to form the filter device of the present invention.
The structure of the filter device of the present invention and the method by which the porous metal filter 18 is sealed into the tubular thermoplastic connector 16 to form a filter device of the present invention may best be understood by referring to FIGS. 2 to 5.
The thermoplastic connector 16 is of generally tubular shape and has internal peripheral wall 19 defining a longitudinal passage 20 extending therethrough. The outer or proximal end 22 of the passage 20 is tapered outwardly (commonly referred to in the medical field as a female luer taper) to facilitate sealing reception of the tip of a syringe (or other tubular member) to which the proximal end of the fitting 16 is to be connected. The forward or distal end of the passage through the stem 24 may be cylindrical or tapered to receive the butt end of the needle cannula 12, which may, for example, be epoxy bonded therein.
The intermediate portion of the peripheral wall 19 of passage 20 is provided with a shoulder 30 which functions as a seat for the end of the filter 18. An inwardlyprojecting annular ring or bead 32 is provided on the interior wall 19 of the fitting 16 just above the shoulder or seat 30. The internal diameter of the bead 32 is slightly less than the outer diameter of the filter 18 so that the end of the filter 18 can be force-fit into the bead 32 in a manner and for a purpose described more fully below.
The term thermoplastic, as used herein, is intended to refer to any plastic material that will soften when heated and re-solidify or harden when cooled. The thermoplastic fitting or connector 16 is preferably constructed of a relatively rigid thermoplastic such as polypropylene, polycarbonate or polyethylene terephthalate.
The filter 18 is preferably cylindrical cup-shaped in form, having a closed rear end 36 and an open forward end 38 defined by a forward peripheral wall 39.
The filter 18 is preferably formed of a porous, sintered, powdered stainless steel. The particular formation and interrelationship of the particles of the filter 18 are important, but do not constitute a part of the invention of this patent. The composition of the filter 18 may be of the type described in copending application Ser. No. 354,309, filed Apr. 25, 1973.
The filter element 18 is positioned and sealed or bonded in the tubular fitting 16 in the following manner.
The filter element 18 is inserted, open end first, into the passage 20 of the fitting 16 by means of a suitable tool, such as the insertion tip 40 of a suitable vacuum tool, as shown in FIG. 2. The filter element 18 is held on the tool 40 by suction, and is pressed downwardly through the plastic annular ring or bead 32 until the forward peripheral wall 39 of the open forward end 38 rests or seats on the annular shoulder 30. As noted above, the outer diameter of the filter element 18 is slightly larger than the internal diameter of the annular bead 32 so that the forward end of the filter 18 is forcefit in the annular bead 32 to compress and deform the bead (see FIG. 3).
With the filter element 18 in place (i.e., with the forward end wall 39 of the filter abutting the shoulder 30 in the fitting l6 and the forward end portion of the peripheral wall of the filter l8 force-fit in the annular bead 32), the filter element 18 is heated to a temperature and for such a time to heat the thermoplastic bead 32, which melts or softens and flows into the pores in a continuous ring around the forward end portion of the outer peripheral wall of the filter element 18. As shown in FIG. 4, it is contemplated that the filter element 18 may be heated by the electromagnetic field generated by induction heating coils 44. It is contemplated, however, that other means of heating the filter element 18 may be employed so long as such heating means does not interfere with the compressive force exerted by the filter element on the annular bead 32.
FIG. is an enlarged sectional view illustrating the intrusion of the plastic bead 32 into the pores around the outer peripheral wall of the forward end portion of the filter element 18 after the bead has cooled and resolidified.
It is to be noted that the seal or bond formed between the bead 32 and the forward end portion of the outer surface of filter element 18 is a relatively thin continuous ring which does not significantly reduce the effective surface area of the filter which is exposed to the solution to be filtered. Thus, the seal will not inhibit the flow rate of the solution which must pass through the 6 LII element 18 at a maximum to insure that the flow rate of the solution passed through the filter may be maintained at the desired level. It will also be noted that the cylindrical cup shape of the filter element 18 maximizes the effective surface area of the filter which is exposed to the solution to be passed therethrough, consistant with the over-all size limitations imposed by the fitting into which it is inserted, to maximize the permissible flow rate of the solution.
From the foregoing, it will be appreciated that the method of the present invention provides a filter device for medical injection equipment and the like which is relatively inexpensive, efficient and readily adaptable for use with existing injection and infusion equipment (e.g., plastic fittings, such as injection needle hubs). The ring seal or bond formed between the tubular fitting and the peripheral wall of the filter provides an effective continuous seal which does not interfere with the critical, permissible flow rate of solution through the filter, yet insures a fluid tight seal to prevent fluid from passing around, rather than through, the filter element. Thus, the method and resulting filter device of the present invention satisfies the existing need in the industry for a device which will effectively eliminate or minimize particulate contamination in parenteral fluids to be injected into patients.
It is contemplated, of course, that numerous changes and modifications may be made to the particular embodiments of the method and filter device described above and shown in the drawings without departing from the scope of the present invention. For example, while a cylindrical cup-shaped filter has been shown and described as a preferable embodiment, it is contemplated that method and filter devices of the present invention may employ filter elements of other shapes, such as disk shapes, plate shapes and rounded cup shapes.
Accordingly, it is intended that the scope of the present invention be limited only by the scope of the appended claims.
I claim:
1. A filter device for medical infusion and injection equipment and the like, comprising:
a generally cylindrical, cup-shaped, porous, sintered powdered metal filter element having an open distal end and a closed proximal end;
a tubular, thermoplastic fitting having a longitudinal passage extending axially therethrough; a radiallyinwardly projecting annulus on the internal peripheral wall of said longitudinal passage; means defining a radially inwardly projecting seat on the internal peripheral wall of said longitudinal passage;
said filter element having a peripheral edge at said open distal end thereof; said peripheral edge of said filter element being disposed on and in contact with said seat of said fitting; said radially inwardly projecting annulus on the internal peripheral wall on said longitudinal passage having been softened and forced into pores of said filter element along a continuous peripheral ring adjacent to said peripheral edge of said open distal end of said filter element.
2. A filter device for medical infusion and injection equipment and the like, comprising: a tubular member formed of relatively rigid thermoplastic, said tubular member having an internal annular projection therein; a sintered, porous, powdered metal filter having an end 3. The filter device of claim 2 wherein said filter is made from stainless steel particles. 4. The filter device article of claim 2 wherein said thermoplastic is a polycarbonate.
5. The filter device of claim 2 wherein said thermoplastic is a polyethylene terephthalate.
6. The filter device of claim 2 wherein said thermoplastic is a polypropylene.
7. A filter device for use as a part of an apparatus for the infusion or injection of parenteral fluid comprising:
a fitting formed of relatively rigid thermoplastic having an interior peripheral wall defining a passage therethrough; an annular projection on said interior wall; and a shoulder on said interior wall; said shoulder being spaced from said projection;
a sintered, porous, powdered stainless steel tubular filter having a closed end and a continuous peripheral wall extending from said end and adapted for a force fit into said annular projection and to abut said shoulder in said fitting;
said annular projection and said peripheral wall of said filter being in leakproof relation as a result of said filter and said annular projection having been heated to a temperature such that a portion of said projection flowed into pores of said peripheral wall and the subsequent cooling of said filter and said projection.

Claims (7)

1. A filter device for medical infusion and injection equipment and the like, comprising: a generally cylindrical, cup-shaped, porous, sintered powdered metal filter element having an open distal end and a closed proximal end; a tubular, thermoplastic fitting having a longitudinal passage extending axially therethrough; a radially-inwardly projecting annulus on the internal peripheral wall of said longitudinal passage; means defining a radially inwardly projecting seat on the internal peripheral wall of said longitudinal passage; said filter element having a peripheral edge at said open distal end thereof; said peripheral edge of said filter element being disposed on and in contact with said seat of said fitting; said radially inwardly projecting annulus on the internal peripheral wall on said longitudinal passage having been softened and forced into pores of said filter element along a continuous peripheral ring adjacent to said peripheral edge of said open distal end of said filter element.
2. A filter device for medical infusion and injection equipment and the like, comprising: a tubular member formed of relatively rigid thermoplastic, said tubular member having an internal annular projection therein; a sintered, porous, powdered metal filter having an end surface and a continuous peripheral wall extending from said end surface; said annular projection of said tubular member and said peripheral wall of said filter being sealed to one another along a continuous peripheral ring as a result of said filter and said annular projection having been heated to a temperature such that a portion of said annular projection flowed into pores of said peripheral wall of said filter and the subsequent cooling of said filter body and said annular projection.
3. The filter device of claim 2 wherein said filter is made from stainless steel particles.
4. The filter device article of claim 2 wherein said thermoplastic is a polycarbonate.
5. The filter device of claim 2 wherein said thermoplastic is a polyethylene terephthalate.
6. The filter device of claim 2 wherein said thermoplastic is a polypropylene.
7. A filter device for use as a part of an apparatus for the infusion or injection of parenteral fluid comprising: a fitting formed of relatively rigid thermoplastic having an interior peripheral wall defining a passage therethrough; an annular projection on said interior wall; and a shoulder on said interior wall; said shoulder being spaced from said projection; a sintered, porous, powdered stainless steel tubular filter having a closed end and a continuous peripheral wall extending from said end and adapted for a force fit into said annular projection and to abut said shoulder in said fittinG; said annular projection and said peripheral wall of said filter being in leakproof relation as a result of said filter and said annular projection having been heated to a temperature such that a portion of said projection flowed into pores of said peripheral wall and the subsequent cooling of said filter and said projection.
US05323726 1973-01-15 1973-01-15 Filter device in tubular fitting for medical injection equipment and the like Expired - Lifetime US3817389A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US05323726 US3817389A (en) 1973-01-15 1973-01-15 Filter device in tubular fitting for medical injection equipment and the like
AU61263/73A AU485504B2 (en) 1973-01-15 1973-10-11 Method of sealing filter in tubular fitting for medical injection equipment andthe like and resulting filter
JP11977773A JPS49103487A (en) 1973-01-15 1973-10-24
CA189,405A CA1032878A (en) 1973-01-15 1974-01-03 Sealing filter element in tubing
BE139594A BE809478A (en) 1973-01-15 1974-01-07 PROCESS FOR SEALING A FILTER IN THE TUBULAR TIP OF A MEDICAL INJECTOR OR EQUIVALENT
FR7401000A FR2324316A1 (en) 1973-01-15 1974-01-11 PROCESS FOR SEALING A FILTER INSIDE A TUBULAR FRAME FOR MEDICAL AND SIMILAR INJECTION EQUIPMENT, AND FILTERING DEVICE OBTAINED
DE2401782A DE2401782C2 (en) 1973-01-15 1974-01-15 Needle sleeve with a filter element of medical infusion and injection devices and method for producing the same
GB5907373A GB1462780A (en) 1973-01-15 1974-01-15 Filter device for medical injection equipment and the like
US05/438,298 US3976529A (en) 1973-01-15 1974-01-31 Method of sealing filter in tubular fitting for medical injection equipment and the like

Applications Claiming Priority (1)

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US05323726 US3817389A (en) 1973-01-15 1973-01-15 Filter device in tubular fitting for medical injection equipment and the like

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US05/438,298 Division US3976529A (en) 1973-01-15 1974-01-31 Method of sealing filter in tubular fitting for medical injection equipment and the like

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US3817389A true US3817389A (en) 1974-06-18

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JP (1) JPS49103487A (en)
BE (1) BE809478A (en)
CA (1) CA1032878A (en)
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GB (1) GB1462780A (en)

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US3933652A (en) * 1973-04-25 1976-01-20 Sherwood Medical Industries Inc. Process of manufacturing a porous, stainless steel filter element and sealing it in a tubular fitting, and resulting filter
US3970084A (en) * 1972-10-20 1976-07-20 Burron Medical Products, Inc. Intravenous injection apparatus and needle adapter with filter and method of making same
US4014797A (en) * 1973-12-11 1977-03-29 Burron Medical Products, Inc. Intravenous injection apparatus and needle adapter with filter and method of making same
US4076027A (en) * 1976-05-07 1978-02-28 Sherwood Medical Industries Inc. Fluid transfer device
US4127131A (en) * 1977-06-20 1978-11-28 Johnson & Johnson Hub assembly for use in the filtration of fluids and method of making the same
US4227527A (en) * 1978-10-23 1980-10-14 Baxter Travenol Laboratories, Inc. Sterile air vent
US4259187A (en) * 1979-06-07 1981-03-31 Baxter Travenol Laboratories, Inc. Intravenous fluid filter
US4265760A (en) * 1979-02-26 1981-05-05 Becton Dickinson & Company Device for dilution and delivery of in vivo chemicals
US4273656A (en) * 1978-05-09 1981-06-16 Aisan Industry Co., Ltd. Filter for fluid passage
US4574173A (en) * 1984-05-04 1986-03-04 Warner-Lambert Company Device for RF welding an IV tube to a catheter lumen
US4838881A (en) * 1984-05-04 1989-06-13 Deseret Medical, Inc. Multilumen catheter and associated IV tubing
WO1997000970A1 (en) * 1995-06-22 1997-01-09 Institut Textile De France Method for adsorbing antimicrobial agents contained in a biological fluid, and apparatus therefor
EP0765727A2 (en) * 1995-09-27 1997-04-02 Arbor Technologies, Inc. Improved filter assembly and method of making same
WO1998005430A1 (en) * 1996-08-05 1998-02-12 Schering Aktiengesellschaft Process and device for separating magnetic materials from pharmaceutical compositions, their starting or intermediate products and agents produced by means of this device
US5797869A (en) * 1987-12-22 1998-08-25 Vas-Cath Incorporated Multiple lumen catheter
US5873499A (en) * 1996-08-14 1999-02-23 Scientific Resources, Inc. Pressure breakaway dispensing gun
US6524302B2 (en) 2001-04-26 2003-02-25 Scimed Life Systems, Inc. Multi-lumen catheter
US20030236507A1 (en) * 2002-06-19 2003-12-25 Brigham Lynette E. Containerless tissue sample collection trap
US6685665B2 (en) * 2000-09-08 2004-02-03 Pall Corporation Cannula assembly
US20050124073A1 (en) * 2003-12-09 2005-06-09 Entire Interest Fat collection and preparation system and method
US20070075012A1 (en) * 2005-10-05 2007-04-05 Estochen Edwin G Tubular assembly and method
US20110299170A1 (en) * 2010-05-03 2011-12-08 Magna Mirrors Of America, Inc. Electro-optic rearview mirror element with fill port filter and method of manufacturing electro-optic rearview mirror element
EP2695629A2 (en) * 2011-04-08 2014-02-12 Zamart Co.,ltd Filter needle
US9125992B2 (en) 2011-09-16 2015-09-08 Melvin A. Finke Fluid delivery device with filtration
US9454054B2 (en) 2013-11-18 2016-09-27 Magna Mirrors Of America, Inc. Electro-optic mirror element and process of making same
US20160333305A1 (en) * 2015-05-15 2016-11-17 Black Tie Medical Inc. Device and Method for Breaking Down and Sizing Harvested Fat
US9717882B2 (en) 2014-02-05 2017-08-01 Boston Scientific Scimed, Inc. Multi-lumen catheters and related methods of manufacture
CN108744137A (en) * 2018-08-22 2018-11-06 威海福瑞机器人有限公司 A kind of blood transfusion apparatus strainer is automatically separated and assembling device
WO2022040256A1 (en) * 2020-08-21 2022-02-24 University Of Washington Vaccine generation
US11425905B2 (en) 2020-09-02 2022-08-30 University Of Washington Antimicrobial preventive netting
US11458220B2 (en) 2020-11-12 2022-10-04 Singletto Inc. Microbial disinfection for personal protection equipment
US11612669B2 (en) 2020-08-21 2023-03-28 University Of Washington Disinfection method and apparatus

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Cited By (49)

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US3970084A (en) * 1972-10-20 1976-07-20 Burron Medical Products, Inc. Intravenous injection apparatus and needle adapter with filter and method of making same
US3933652A (en) * 1973-04-25 1976-01-20 Sherwood Medical Industries Inc. Process of manufacturing a porous, stainless steel filter element and sealing it in a tubular fitting, and resulting filter
US4014797A (en) * 1973-12-11 1977-03-29 Burron Medical Products, Inc. Intravenous injection apparatus and needle adapter with filter and method of making same
US4076027A (en) * 1976-05-07 1978-02-28 Sherwood Medical Industries Inc. Fluid transfer device
US4127131A (en) * 1977-06-20 1978-11-28 Johnson & Johnson Hub assembly for use in the filtration of fluids and method of making the same
US4273656A (en) * 1978-05-09 1981-06-16 Aisan Industry Co., Ltd. Filter for fluid passage
US4227527A (en) * 1978-10-23 1980-10-14 Baxter Travenol Laboratories, Inc. Sterile air vent
US4265760A (en) * 1979-02-26 1981-05-05 Becton Dickinson & Company Device for dilution and delivery of in vivo chemicals
US4259187A (en) * 1979-06-07 1981-03-31 Baxter Travenol Laboratories, Inc. Intravenous fluid filter
US4574173A (en) * 1984-05-04 1986-03-04 Warner-Lambert Company Device for RF welding an IV tube to a catheter lumen
US4838881A (en) * 1984-05-04 1989-06-13 Deseret Medical, Inc. Multilumen catheter and associated IV tubing
US5797869A (en) * 1987-12-22 1998-08-25 Vas-Cath Incorporated Multiple lumen catheter
US7229429B2 (en) 1987-12-22 2007-06-12 Vas-Cath Inc. Multiple lumen catheter
US6206849B1 (en) 1987-12-22 2001-03-27 Vas-Cath Incorporated Multiple lumen catheter
WO1997000970A1 (en) * 1995-06-22 1997-01-09 Institut Textile De France Method for adsorbing antimicrobial agents contained in a biological fluid, and apparatus therefor
EP0765727A2 (en) * 1995-09-27 1997-04-02 Arbor Technologies, Inc. Improved filter assembly and method of making same
EP0765727A3 (en) * 1995-09-27 1998-05-06 Arbor Technologies, Inc. Improved filter assembly and method of making same
US6517813B1 (en) 1996-08-05 2003-02-11 Schering Ag Device and process for separating magnetic materials from pharmaceutical preparations, their starting or intermediate products, as well as agents that are produced with the aid of said device
US20030108613A1 (en) * 1996-08-05 2003-06-12 Schering Ag Device and process for separating magnetic materials from pharmaceutical preparations, their starting or intermediate products, as well as agents that are produced with the aid of said device
WO1998005430A1 (en) * 1996-08-05 1998-02-12 Schering Aktiengesellschaft Process and device for separating magnetic materials from pharmaceutical compositions, their starting or intermediate products and agents produced by means of this device
US5873499A (en) * 1996-08-14 1999-02-23 Scientific Resources, Inc. Pressure breakaway dispensing gun
US6685665B2 (en) * 2000-09-08 2004-02-03 Pall Corporation Cannula assembly
US6524302B2 (en) 2001-04-26 2003-02-25 Scimed Life Systems, Inc. Multi-lumen catheter
US20030236507A1 (en) * 2002-06-19 2003-12-25 Brigham Lynette E. Containerless tissue sample collection trap
US7182754B2 (en) * 2002-06-19 2007-02-27 N.M. Beale Company Containerless tissue sample collection trap
US20050123895A1 (en) * 2003-12-09 2005-06-09 Freund Robert M. Fat collection and preparation system and method
US20050124073A1 (en) * 2003-12-09 2005-06-09 Entire Interest Fat collection and preparation system and method
US7306740B2 (en) 2003-12-09 2007-12-11 Lipose Corporation Fat collection and preparation system and method
US20080057597A1 (en) * 2003-12-09 2008-03-06 Freund Robert M Fat collection and preparation system and method
US7488427B2 (en) 2003-12-09 2009-02-10 Lipose Corporation Fat collection and preparation system and method
US20070075012A1 (en) * 2005-10-05 2007-04-05 Estochen Edwin G Tubular assembly and method
US20110299170A1 (en) * 2010-05-03 2011-12-08 Magna Mirrors Of America, Inc. Electro-optic rearview mirror element with fill port filter and method of manufacturing electro-optic rearview mirror element
EP2695629A2 (en) * 2011-04-08 2014-02-12 Zamart Co.,ltd Filter needle
EP2695629A4 (en) * 2011-04-08 2014-12-31 Zamart Co Ltd Filter needle
US9125992B2 (en) 2011-09-16 2015-09-08 Melvin A. Finke Fluid delivery device with filtration
US9454054B2 (en) 2013-11-18 2016-09-27 Magna Mirrors Of America, Inc. Electro-optic mirror element and process of making same
US10782584B2 (en) 2013-11-18 2020-09-22 Magna Mirrors Of America, Inc. System for filling electrochromic mirror element
US9897889B2 (en) 2013-11-18 2018-02-20 Magna Mirrors Of America, Inc. Electro-optic mirror element and process of making same
US9717882B2 (en) 2014-02-05 2017-08-01 Boston Scientific Scimed, Inc. Multi-lumen catheters and related methods of manufacture
US20160333305A1 (en) * 2015-05-15 2016-11-17 Black Tie Medical Inc. Device and Method for Breaking Down and Sizing Harvested Fat
US10927347B2 (en) * 2015-05-15 2021-02-23 Black Tie Medical Inc. Device and method for breaking down and sizing harvested fat
CN108744137A (en) * 2018-08-22 2018-11-06 威海福瑞机器人有限公司 A kind of blood transfusion apparatus strainer is automatically separated and assembling device
CN108744137B (en) * 2018-08-22 2024-02-27 威海福瑞机器人有限公司 Automatic separation and assembly device for blood transfusion device filter screen
WO2022040256A1 (en) * 2020-08-21 2022-02-24 University Of Washington Vaccine generation
US11529153B2 (en) 2020-08-21 2022-12-20 University Of Washington Vaccine generation
US11612669B2 (en) 2020-08-21 2023-03-28 University Of Washington Disinfection method and apparatus
US11425905B2 (en) 2020-09-02 2022-08-30 University Of Washington Antimicrobial preventive netting
US11458220B2 (en) 2020-11-12 2022-10-04 Singletto Inc. Microbial disinfection for personal protection equipment
US11925717B2 (en) 2020-11-12 2024-03-12 Singletto Inc. Microbial disinfection for personal protection equipment

Also Published As

Publication number Publication date
BE809478A (en) 1974-05-02
JPS49103487A (en) 1974-09-30
FR2324316B1 (en) 1979-06-15
AU6126373A (en) 1975-04-17
GB1462780A (en) 1977-01-26
FR2324316A1 (en) 1977-04-15
CA1032878A (en) 1978-06-13

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