US3809298A - Syringe - Google Patents

Syringe Download PDF

Info

Publication number
US3809298A
US3809298A US00380461A US38046173A US3809298A US 3809298 A US3809298 A US 3809298A US 00380461 A US00380461 A US 00380461A US 38046173 A US38046173 A US 38046173A US 3809298 A US3809298 A US 3809298A
Authority
US
United States
Prior art keywords
barrel
bore
plunger
syringe
enlarged opening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00380461A
Inventor
R Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PRECISION SAMPLING CORP
Original Assignee
PRECISION SAMPLING CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PRECISION SAMPLING CORP filed Critical PRECISION SAMPLING CORP
Priority to US00380461A priority Critical patent/US3809298A/en
Application granted granted Critical
Publication of US3809298A publication Critical patent/US3809298A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B01L3/0217—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids of the plunger pump type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A61M5/31531—Microsyringes, e.g. having piston bore diameter close or equal to needle shaft diameter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced
    • G01N2035/1018—Detecting inhomogeneities, e.g. foam, bubbles, clots
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1053—General features of the devices using the transfer device for another function for separating part of the liquid, e.g. filters, extraction phase

Definitions

  • ABSTRACT A liquid syringe, particularly a microsyringe, of a type suitable for separating a trapped gas from a liquid, and for dispensing small, preselected, accurately measured quantities of the liquid specimen into a media, e.g., a G.C. or mass spectrograph.
  • the syringe is characterized by a barrel, a tubular needle mounted on the forward end of the barrel and a reciprocable plunger mounted on the opposite end of the barrel.
  • the bore through the needle and barrel are communicated one with the other, and the bore of the barrel is provided with an opening of cross-section larger than the crosssection of the bore forward of the enlarged opening.
  • the enlarged opening permits separation of gas from a liquid specimen.
  • a specific object of the invention is to provide a syringe of such character which is particularly useful for the injection of liquid specimens on the order of only about 0.01 to about 5 microliters, or fractional parts thereof.
  • a further object is to provide a syringe of the kind characterized which is of simple construction, providing a device which can be readily manufactured, is easy to use, and is conveniently disassembled for cleaning and maintenance.
  • the novel apparatus of the present invention characterized as a liquid syringe, particularly a microsyringe, wherein is included the usual barrel, a cannula or needle mounted or positioned in the forward end of the barrel, and a reciprocable plunger mounted in the rearward end of the barrel.
  • the barrel and needle are each formed by an enclosing wall, defining in each member an axial opening or bore, and the bore of the needle and barrel are communicated one with the other.
  • the bore of the barrel is provided with an enlarged open section toward the rearward portionthereof, throughwhich the forward end of the plunger travels, the portion of the bore forward of the said enlarged open section being of substantially uniform diameter.
  • the outside diameter of the forward endof the plunger is substantially equal to the inside diameter of the bore of the barrel (but smaller than said enlarged open section) within which the'rod or piston is reciprocably mounted, or substantially equal to the inside diameter of both the barrel and needle within which the rod or piston is reciprocably mounted, wherein the path of travel of the plunger in cludes both the bores of the needle and barrel.
  • the forward end of the plunger is capped by a seal of external diameter approximating the inside diameter of the barrel or the inside diameter of both the barrel and needle.
  • the only path for significant ingress and egress of liquid into or from the 2 barrel is via an opening at the dispensing end of th needle caused by positive movement of the plunger.
  • FIG. 1 is a perspective view of a preferred type of liquid syringe embodying the present invention.
  • FIGS. 2 through 5 showing the syringe of FIG. 1 in partial section, depict graphically a series of views describing the filling of the syringe with a liquid specimen
  • FIG. I there is illustrated, in perspective,
  • a syringe which includes a barrel 11 (of transparent character) formed by a sidewall which completely encloses a central axial opening or bore 12.
  • the external portion of the barrel 11, if desired, is suitably scribed with indicia marks indicating volumetric measurements.
  • the rearward portion of the axial opening or bore 12, it will be observed, is provided with an enlarged open portion or segment 13, the bore 12 forward of enlarged segment 13 being of substantially uniform plunger 15 is provided with a resilient cap or seal 16, 7
  • FIG. 2 the dispensing, or open, end 9 of hollow needle 14 is immersed in a source of liquid (not shown) and retraction of plunger 15 (or movement of the plunger in the direction shown by the open arrow) is begun.
  • plunger 15 moves rearward, liquid passes through the opening at the dispensing end 9 of needle 14 and into the axial opening or bore of the needle, with a small amount of air, and begins to fill the forward end of bore 12.
  • an air bubble 18 is trapped forward of plunger seal 16
  • the syringe is constructed of materials substantially inert or nonreactive to the chemical or corrosive action of the liquid specimens to be measured and dispensed.
  • the barrel of the syringe is normally constructed of glass, but can be constructed of a plastic or plastic-like material.
  • the needle and plunger are normally constructed of metal.
  • the seal is constructed of a resilient material, generally a selflubricated type of plastic, and preferably polytetrafluoroethylene e.g., Teflon).
  • the enlarged opening within the bore must be of greater inside diameter than the inside diameter of the bore forward of the said enlarged opening, and larger than the external diameter of the forward end of the plunger.
  • the inside diameter of the enlarged opening at the location of the largest part of the crosssection ranges from about 1.25 to about 2, and preferably from about 1.3 to about 1.75 times the inside diameter of the bore forward of the enlarged opening, on the other hand, is generally somewhat greater than the length of the plunger seal, where a seal is employed.
  • the length of the enlarged opening ranges no greater than about 1.5 to 2 times the length of the seal.
  • a syringe for use in separating trapped gas from liquid, and for dispensing small, 'pre-selected, accurately measured quantities of the liquid specimen into a media such as an analytical instrument comprising the combination of a barrel formed by an enclosing side wall defining a central bore, the bore being of substantially uniform cross-section forward of an opening of enlarged cross-section within the bore located rear-.
  • a hollow needle mounted on the front end of the barrel, the bore of which is in open communication with the bore through the barrel,
  • a plunger reciprocably mounted within the bore from the rearward end of the barrel, the forward end of the plunger being traversible through the enlarged opening within the bore, and within the bore of the barrel forward of the enlarged opening itself,
  • volumetric cav pacity ranges from about 0.01 to about 5 microliters.

Abstract

A liquid syringe, particularly a microsyringe, of a type suitable for separating a trapped gas from a liquid, and for dispensing small, preselected, accurately measured quantities of the liquid specimen into a media, e.g., a G.C. or mass spectrograph. The syringe is characterized by a barrel, a tubular needle mounted on the forward end of the barrel and a reciprocable plunger mounted on the opposite end of the barrel. The bore through the needle and barrel are communicated one with the other, and the bore of the barrel is provided with an opening of cross-section larger than the cross-section of the bore forward of the enlarged opening. The enlarged opening permits separation of gas from a liquid specimen. By withdrawal of the forward end of the plunger rearwardly into this opening, gas enters into the enlarged opening, and on forward movement of the plunger the liquid is separated forward of the plunger tip and gas is transmitted rearwardly through the annulus between the plunger and inside wall of the barrel rearwardly of the enlarged opening.

Description

United States Patent [191 Harris, Sr. et al.
[451 May 7,1974
[ SYRINGE [75] Inventors: Rano J. Harris, Sr.; Rano J. Harris,
Jr., both of Baton Rouge, La.
[73] Assignee: Precision Sampling Corporation,
Baton Rouge, La.
[22] Filed: July 18, 19.73
[21] Appl. No.: 380,461
[52] US. Cl.. 222/386, 128/218 P, 239/331 Primary Examiner-M. Henson Wood, Jr. Assistant Examiner-Michael Y. Mar
[57] ABSTRACT A liquid syringe, particularly a microsyringe, of a type suitable for separating a trapped gas from a liquid, and for dispensing small, preselected, accurately measured quantities of the liquid specimen into a media, e.g., a G.C. or mass spectrograph. The syringe is characterized by a barrel, a tubular needle mounted on the forward end of the barrel and a reciprocable plunger mounted on the opposite end of the barrel. The bore through the needle and barrel are communicated one with the other, and the bore of the barrel is provided with an opening of cross-section larger than the crosssection of the bore forward of the enlarged opening. The enlarged opening permits separation of gas from a liquid specimen. By withdrawal of the forward end of the plunger rearwardly into this opening, gas enters into the enlarged opening, and on forward movement of the plunger the liquid is separated forward of the plunger tip and gas is transmitted rearwardly through the annulus between the plunger and inside wall of the barrel rearwardly of the enlarged opening.
9 Claims, 5 Drawing Figures PATENTEUMAY 1 I914 3309.298
FIGJ
SYRINGE It has long been a desideratum in the art to provide a syringe, particularly a microsyringe, from which a trapped gas, e.g., air, can be readily, and conveniently, expelled after having been filled with a liquid. Prior art liquid syringes thussuffer the disadvantage that the plunger generally has to be repeatedly reciprocated while the dispensing end of the needle thereof is maintained below the surface of the liquid specimen being sampled to purge the needle and barrel of an occluded bubble, or bubbles, e.g., air. The penalty for failure to effectively eliminate the air results in error in the measurement of the actual volume of liquid sample intended for injection, which source of error can be particularly significant in high precision microsyringes of the type used for injection of very small and infinitesimal quantities of accurately measured liquid specimens into a media, e.g., modern analytical instruments such as a mass spectrometer, gas chromatograph, and
.the like. The necessity for continued reciprocation of the plunger in attempts to eliminategas bubbles, in handling some typesof liquid specimens, also creates emulsions. It also occasions increased plunger wear, and sometimes causes plunger damage and abrasion.
It is accordingly, a primary objective of the present invention to obviate these disadvantages and provide a new and improved syringe, particularly a microsyringe, capable of manual or automated use.
A specific object of the invention is to provide a syringe of such character which is particularly useful for the injection of liquid specimens on the order of only about 0.01 to about 5 microliters, or fractional parts thereof.
A further object is to provide a syringe of the kind characterized which is of simple construction, providing a device which can be readily manufactured, is easy to use, and is conveniently disassembled for cleaning and maintenance.
These objects, and others, are provided by the novel apparatus of the present invention characterized as a liquid syringe, particularly a microsyringe, wherein is included the usual barrel, a cannula or needle mounted or positioned in the forward end of the barrel, and a reciprocable plunger mounted in the rearward end of the barrel. The barrel and needle are each formed by an enclosing wall, defining in each member an axial opening or bore, and the bore of the needle and barrel are communicated one with the other. The bore of the barrel is provided with an enlarged open section toward the rearward portionthereof, throughwhich the forward end of the plunger travels, the portion of the bore forward of the said enlarged open section being of substantially uniform diameter. The outside diameter of the forward endof the plunger is substantially equal to the inside diameter of the bore of the barrel (but smaller than said enlarged open section) within which the'rod or piston is reciprocably mounted, or substantially equal to the inside diameter of both the barrel and needle within which the rod or piston is reciprocably mounted, wherein the path of travel of the plunger in cludes both the bores of the needle and barrel. In a preferred form, the forward end of the plunger is capped by a seal of external diameter approximating the inside diameter of the barrel or the inside diameter of both the barrel and needle. In either form, the only path for significant ingress and egress of liquid into or from the 2 barrel is via an opening at the dispensing end of th needle caused by positive movement of the plunger.
' These and other salient features and advantages of the invention are further and more fully described by the following description which makes reference to the attached drawings.
Referring to the drawings:
FIG. 1 is a perspective view of a preferred type of liquid syringe embodying the present invention, and
FIGS. 2 through 5, showing the syringe of FIG. 1 in partial section, depict graphically a series of views describing the filling of the syringe with a liquid specimen,
elimination of trapped air, and discharge of an accurately measured quantity of the liquid specimen.
Referring to FIG. I there is illustrated, in perspective,
a syringe which includes a barrel 11 (of transparent character) formed by a sidewall which completely encloses a central axial opening or bore 12. The external portion of the barrel 11, if desired, is suitably scribed with indicia marks indicating volumetric measurements. The rearward portion of the axial opening or bore 12, it will be observed, is provided with an enlarged open portion or segment 13, the bore 12 forward of enlarged segment 13 being of substantially uniform plunger 15 is provided with a resilient cap or seal 16, 7
preferably of a type described by application Ser. No.
- 66,13 6, filed Aug. 21, 1970, the outside diameter of which approximates the inside diameter of the bore 12 forward of the enlarged opening 13. The rearward end of plunger 15, for convenience, is provided with a thumb button 17.
The nature and function of the enlarged segment 13 of bore 12 in eliminating a trapped air bubble is described by reference to the series of views depicted by reference to FIGS. 2 through 5 Referring first to FIG. 2, the dispensing, or open, end 9 of hollow needle 14 is immersed in a source of liquid (not shown) and retraction of plunger 15 (or movement of the plunger in the direction shown by the open arrow) is begun. As
plunger 15 moves rearward, liquid passes through the opening at the dispensing end 9 of needle 14 and into the axial opening or bore of the needle, with a small amount of air, and begins to fill the forward end of bore 12. Thus, it will be observed, as depicted in FIG. 1, that an air bubble 18 is trapped forward of plunger seal 16,
or between liquid 19 and plunger seal 16. The trapped reference to FIG. 4, the plunger 15 is pushed forwardly into the enlarged opening 13 at which time the air is displaced through the annulus between the bore rearward of the seal 16 and inside wall of the rearward segment of bore 12. On continued forward movement of plunger 15, the seal 16 enters into the bore 12 forward of the enlarged opening 13, such that only liquid is located forward of the forward end of seal 16. A small residuum of liquid may remain within the enlarged opening 16 which itself creates no error in that-only the liquid forward of plunger seal 16 is measured and injected. The cycle can be repeated ad infinitum.
It is apparent that various modifications and changes can be made without departingthe spirit and scope of the present invention. The syringe is constructed of materials substantially inert or nonreactive to the chemical or corrosive action of the liquid specimens to be measured and dispensed. The barrel of the syringe is normally constructed of glass, but can be constructed of a plastic or plastic-like material. The needle and plunger are normally constructed of metal. The seal is constructed of a resilient material, generally a selflubricated type of plastic, and preferably polytetrafluoroethylene e.g., Teflon).
The enlarged opening within the bore must be of greater inside diameter than the inside diameter of the bore forward of the said enlarged opening, and larger than the external diameter of the forward end of the plunger. Generally,'the inside diameter of the enlarged opening at the location of the largest part of the crosssection) ranges from about 1.25 to about 2, and preferably from about 1.3 to about 1.75 times the inside diameter of the bore forward of the enlarged opening, on the other hand, is generally somewhat greater than the length of the plunger seal, where a seal is employed. Generally, however, the length of the enlarged opening ranges no greater than about 1.5 to 2 times the length of the seal.
It is apparent that various changes, such as in the absolute or relative dimensions of the parts, materials used, and the like, can be made without departing the spirit and scope of the invention. Having described the invention, what is claimed is:
l. A syringe for use in separating trapped gas from liquid, and for dispensing small, 'pre-selected, accurately measured quantities of the liquid specimen into a media such as an analytical instrument, comprising the combination of a barrel formed by an enclosing side wall defining a central bore, the bore being of substantially uniform cross-section forward of an opening of enlarged cross-section within the bore located rear-.
wardly within the barrel,
a hollow needle mounted on the front end of the barrel, the bore of which is in open communication with the bore through the barrel,
a plunger reciprocably mounted within the bore from the rearward end of the barrel, the forward end of the plunger being traversible through the enlarged opening within the bore, and within the bore of the barrel forward of the enlarged opening itself,
whereby gas trapped within a liquid to be dispersed can be separated from the liquid, and a liquid specimen isolated from the gas for measurement and ejection by withdrawal of the forward end of the plunger into the enlarged opening within the bore of the barrel, whereupon by forward movement of the plunger the gas. is extruded through the annulus between the plunger and inside wall of the barrel rearwardly of the enlarged opening, and the liquid trapped for measurement and ejection by forward movement of the plunger.
2. The syringe of claim 1 wherein the enlarged 'opening within the bore of the barrel is of cross-section 5. Thesyringe of claim 4 wherein the enlarged opening is from about 1.5 to 2 times the length of the seal.
6. The syringe of claim 5 whereinthe seal is constituted of plastic.
7. The syringe of claim 5 wherein the seal is constituted of Teflon.
8. The syringe of claim 1 wherein the barrel is constituted of a transparent material, and scribed with indicia marks representative of the volumetric capacity of thebarrel.
9. The syringe of claim 8 wherein the volumetric cav pacity ranges from about 0.01 to about 5 microliters.

Claims (9)

1. A syringe for use in separating trapped gas from liquid, and for dispensing small, pre-selected, accurately measured quantities of the liquid specimen into a media such as an analytical instrument, comprising the combination of a barrel formed by an enclosing side wall defining a central bore, the bore being of substantially uniform cross-section forward of an opening of enlarged cross-section within the bore located rearwardly within the barrel, a hollow needle mounted on the front end of the barrel, the bore of which is in open communication with the bore through the barrel, a plunger reciprocably mounted within the bore from the rearward end of the barrel, the forward end of the plunger being traversible through the enlarged opening within the bore, and within the bore of the barrel forward of the enlarged opening itself, whereby gas trapped within a liquid to be dispersed can be separated from the liquid, and a liquid specimen isolated from the gas for measurement and ejection by withdrawal of the forward end of the plunger into the enlarged opening within the bore of the barrel, whereupon by forward movement of the plunger the gas is extruded through the annulus between the plunger and inside wall of the barrel rearwardly of the enlarged opening, and the liquid trapped for measurement and ejection by forward movement of the plunger.
2. The syringe of claim 1 wherein the enlarged opening within the bore of the barrel is of cross-section ranging from about 1.25 to about 2 times that of the bore forward of said enlarged opening.
3. The syringe of claim 2 wherein the diameter of the enlarged opening ranges from about 1.3 to about 1.75 times the inside diameter of the bore forward of the enlarged opening.
4. The syringe of claim 1 wherein the forward end of the plunger is capped with a seal, and the enlarged opening is of greater length than the length of the seal.
5. The syringe of claim 4 wherein the enlarged opening is from about 1.5 to 2 times the length of the seal.
6. The syringe of claim 5 wherein the seal is constituted of plastic.
7. The syringe of claim 5 wherein the seal is constituted of Teflon.
8. The syringe of claim 1 wherein the barrel is constituted of a transparent material, and scribed with indicia marks representative of the volumetric capacity of the barrel.
9. The syringe of claim 8 wherein the volumetric capacity ranges from about 0.01 to about 5 microliters.
US00380461A 1973-07-18 1973-07-18 Syringe Expired - Lifetime US3809298A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US00380461A US3809298A (en) 1973-07-18 1973-07-18 Syringe

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00380461A US3809298A (en) 1973-07-18 1973-07-18 Syringe

Publications (1)

Publication Number Publication Date
US3809298A true US3809298A (en) 1974-05-07

Family

ID=23501254

Family Applications (1)

Application Number Title Priority Date Filing Date
US00380461A Expired - Lifetime US3809298A (en) 1973-07-18 1973-07-18 Syringe

Country Status (1)

Country Link
US (1) US3809298A (en)

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3960139A (en) * 1975-01-15 1976-06-01 Bailey Donald L Syringe device with means for removing contaminates when drawing blood sample
US3978846A (en) * 1975-01-02 1976-09-07 Bailey Donald L Syringe for taking blood samples
US4340067A (en) * 1980-03-31 1982-07-20 Rattenborg Christen C Blood collection syringe
US4361155A (en) * 1980-10-29 1982-11-30 Anastasio Frank W Blood sampling unit
US4572210A (en) * 1981-07-01 1986-02-25 Marquest Medical Products, Inc. Syringe with means for allowing passage of air while preventing the passage of blood to obtain a gas-free blood sample
US4657028A (en) * 1983-02-21 1987-04-14 Radiometer A/S Blood sampling device
US4662545A (en) * 1984-01-05 1987-05-05 Drummond Scientific Company Disposable capillary tube device
US4664655A (en) * 1986-03-20 1987-05-12 Norman Orentreich High viscosity fluid delivery system
US4758234A (en) * 1986-03-20 1988-07-19 Norman Orentreich High viscosity fluid delivery system
US4784834A (en) * 1985-12-12 1988-11-15 Glasgeratebau Hirschmann Pipette
US4798596A (en) * 1985-10-07 1989-01-17 Muehlbauer Ernst Applicator syringe for a dental compound
US4813602A (en) * 1987-01-02 1989-03-21 Paul Corey Pulsating liquid cleaning device
US4852772A (en) * 1987-12-07 1989-08-01 Genesis Industries, Incorporated Dispenser for viscous fluids
US4893738A (en) * 1988-10-11 1990-01-16 Loctite Corporation Self-aligning positive displacement dispenser
US4952209A (en) * 1985-10-07 1990-08-28 Muehlbauer Ernst Applicator syringe for a dental compound
US6511457B2 (en) * 2001-05-04 2003-01-28 Garey Thompson Airless syringe
US20070224252A1 (en) * 2006-03-27 2007-09-27 Trautman Joseph C Microprojections with capillary control features and method
US20090024095A1 (en) * 2005-09-02 2009-01-22 Laboratoire Aguettant Syringe Designed to Be Pre-Filled Then Sterilized by Steam Autoclaving
US20090209903A1 (en) * 2004-12-01 2009-08-20 Société de Conseils de Recherches et d'Application Scientifiques (S.C.R.A.S.) SAS Device for the injection of a solid or semi-solid implant
US20090270797A1 (en) * 2004-12-01 2009-10-29 Socie'te' De Conseils De Reherches Et D'applica- Tions Scientifiqus (S.C.R.A.S.) Sas Device for injecting a pharmaceutical active principle
US20100270335A1 (en) * 2009-04-24 2010-10-28 Agilent Technologies, Inc. Syringe with Improved Plunger
US20110224612A1 (en) * 2010-03-15 2011-09-15 Becton, Dickinson And Company Medical device including an air evacuation system
US20130035658A1 (en) * 2009-12-09 2013-02-07 Roche Diagnostics International Ag Apparatuses, Systems, And Methods For Filling A Container With A Liquid Drug
US9174007B2 (en) 2010-03-15 2015-11-03 Becton, Dickinson And Company Medical device including an air evacuation system

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3348546A (en) * 1964-12-01 1967-10-24 Ralph R Roberts Intermixing syringe
US3583399A (en) * 1968-09-03 1971-06-08 Astra Chem Ltd Self-aspirating syringe
US3677448A (en) * 1971-01-29 1972-07-18 Precision Sampling Corp Syringe with wire plunger for dispensing infinitesimally small, accurately measured quantities of fluid

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3348546A (en) * 1964-12-01 1967-10-24 Ralph R Roberts Intermixing syringe
US3583399A (en) * 1968-09-03 1971-06-08 Astra Chem Ltd Self-aspirating syringe
US3677448A (en) * 1971-01-29 1972-07-18 Precision Sampling Corp Syringe with wire plunger for dispensing infinitesimally small, accurately measured quantities of fluid

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3978846A (en) * 1975-01-02 1976-09-07 Bailey Donald L Syringe for taking blood samples
US3960139A (en) * 1975-01-15 1976-06-01 Bailey Donald L Syringe device with means for removing contaminates when drawing blood sample
US4340067A (en) * 1980-03-31 1982-07-20 Rattenborg Christen C Blood collection syringe
US4361155A (en) * 1980-10-29 1982-11-30 Anastasio Frank W Blood sampling unit
US4572210A (en) * 1981-07-01 1986-02-25 Marquest Medical Products, Inc. Syringe with means for allowing passage of air while preventing the passage of blood to obtain a gas-free blood sample
US4657028A (en) * 1983-02-21 1987-04-14 Radiometer A/S Blood sampling device
US4662545A (en) * 1984-01-05 1987-05-05 Drummond Scientific Company Disposable capillary tube device
US4904437A (en) * 1985-10-07 1990-02-27 Muehlbauer Ernst Method for producing a syringe body for a dental compound
US4952209A (en) * 1985-10-07 1990-08-28 Muehlbauer Ernst Applicator syringe for a dental compound
US4798596A (en) * 1985-10-07 1989-01-17 Muehlbauer Ernst Applicator syringe for a dental compound
US4784834A (en) * 1985-12-12 1988-11-15 Glasgeratebau Hirschmann Pipette
US4758234A (en) * 1986-03-20 1988-07-19 Norman Orentreich High viscosity fluid delivery system
US4664655A (en) * 1986-03-20 1987-05-12 Norman Orentreich High viscosity fluid delivery system
US4813602A (en) * 1987-01-02 1989-03-21 Paul Corey Pulsating liquid cleaning device
US4852772A (en) * 1987-12-07 1989-08-01 Genesis Industries, Incorporated Dispenser for viscous fluids
US4893738A (en) * 1988-10-11 1990-01-16 Loctite Corporation Self-aligning positive displacement dispenser
US6511457B2 (en) * 2001-05-04 2003-01-28 Garey Thompson Airless syringe
US20090209903A1 (en) * 2004-12-01 2009-08-20 Société de Conseils de Recherches et d'Application Scientifiques (S.C.R.A.S.) SAS Device for the injection of a solid or semi-solid implant
US20090270797A1 (en) * 2004-12-01 2009-10-29 Socie'te' De Conseils De Reherches Et D'applica- Tions Scientifiqus (S.C.R.A.S.) Sas Device for injecting a pharmaceutical active principle
US8348881B2 (en) 2004-12-01 2013-01-08 Société de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S) SAS Device for injecting a pharmaceutical active principle
US8029458B2 (en) * 2004-12-01 2011-10-04 Sociétéde Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.) SAS Device for the injection of a solid or semi-solid implant
US20090024095A1 (en) * 2005-09-02 2009-01-22 Laboratoire Aguettant Syringe Designed to Be Pre-Filled Then Sterilized by Steam Autoclaving
US20070224252A1 (en) * 2006-03-27 2007-09-27 Trautman Joseph C Microprojections with capillary control features and method
US8322577B2 (en) 2009-04-24 2012-12-04 Agilent Technologies, Inc. Syringe with improved plunger
US20100270335A1 (en) * 2009-04-24 2010-10-28 Agilent Technologies, Inc. Syringe with Improved Plunger
US20130035658A1 (en) * 2009-12-09 2013-02-07 Roche Diagnostics International Ag Apparatuses, Systems, And Methods For Filling A Container With A Liquid Drug
US9089647B2 (en) * 2009-12-09 2015-07-28 Roche Diagnostics International Ag Apparatuses, systems, and methods for filling a container with a liquid drug
US8172794B2 (en) 2010-03-15 2012-05-08 Becton, Dickinson And Company Medical device including an air evacuation system
US8172795B2 (en) 2010-03-15 2012-05-08 Becton, Dickinson And Company Medical device including an air evacuation system
US20110224611A1 (en) * 2010-03-15 2011-09-15 Becton, Dickinson And Company Medical device including an air evacuation system
US20110224612A1 (en) * 2010-03-15 2011-09-15 Becton, Dickinson And Company Medical device including an air evacuation system
US9174007B2 (en) 2010-03-15 2015-11-03 Becton, Dickinson And Company Medical device including an air evacuation system
US10173011B2 (en) 2010-03-15 2019-01-08 Becton, Dickinson And Company Medical device including an air evacuation system
US10898650B2 (en) 2010-03-15 2021-01-26 Becton, Dickinson And Company Medical device including an air evacuation system
US11679203B2 (en) 2010-03-15 2023-06-20 Becton, Dickinson And Company Medical device including an air evacuation system

Similar Documents

Publication Publication Date Title
US3809298A (en) Syringe
US3885438A (en) Automatic fluid injector
US4624148A (en) Automatic fluid injector
US4094197A (en) Semi-automatic and automatic fluid injectors
US5320810A (en) Pipette with an axially stationary volume adjusting wheel
US3855867A (en) Liquid transfer pipetting device
US4589421A (en) Sampling device
US3827305A (en) Adjustable pipette
US4404862A (en) Microdispensing springs with a needle in a tubular extension
US3492876A (en) Aliquant discharge device
US3933048A (en) Pipettes
US4875605A (en) Pressurized metering dispenser
US3754443A (en) Automatic fluid injector
US4086062A (en) Digital titration device
US2530909A (en) Mechanical pipette
US3824859A (en) Automatic fluid injector
US3741732A (en) Fractional-fill pipette assembly
US3641823A (en) Injection device
US3730389A (en) Syringe
US3656351A (en) Pipette
US3677448A (en) Syringe with wire plunger for dispensing infinitesimally small, accurately measured quantities of fluid
US3754687A (en) A multi-positional pipetting dispenser
US3921864A (en) Syringes for making precision volume measurements
US3940995A (en) Automatic fluid injector
US3337095A (en) Syringe for automatic proportioning