US3807400A - Inhaling device for medicinal powder compositions - Google Patents

Inhaling device for medicinal powder compositions Download PDF

Info

Publication number
US3807400A
US3807400A US00266243A US26624372A US3807400A US 3807400 A US3807400 A US 3807400A US 00266243 A US00266243 A US 00266243A US 26624372 A US26624372 A US 26624372A US 3807400 A US3807400 A US 3807400A
Authority
US
United States
Prior art keywords
capsule
piercing
medicinal powder
inhaling device
platform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US00266243A
Inventor
S Cocozza
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISF SpA
Original Assignee
ISF SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISF SpA filed Critical ISF SpA
Application granted granted Critical
Publication of US3807400A publication Critical patent/US3807400A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0033Details of the piercing or cutting means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/06Solids
    • A61M2202/064Powder

Definitions

  • an inhaling device for medicinal powder compositions provided in capsule form comprising, in combination, a disc-shaped lower member provided with a cavity in which the said capsule is to be located, which cavity is formed in an upwardly extending platform of said member, and at least one piercing member for said capsule, which piercing member is resiliently biased away from said capsule and projects from said platform, an upper member formed with a number of tangential passages, said upper member providing a lower edge to provide a cam which is able to reciprocate said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with a telescopically extendable mouthpiece, whirling chamher being defined in the region of the extended mouthpiece.
  • FIG. 1 is a side view of an inhaling device in accordance with the invention in its inactive or retracted position;
  • FIG. 2 is a side view of an inhaling device in accordance with the invention in it active or operative position;
  • FIG. 3 is a top plan view of the inhaling device shown in FIGS. 1 and 2;
  • FIG. 4 is a radial partial sectional view of the inhaling device of the invention.
  • FIGS. 5 and 6, on the same scale as FIG. 1, are respectively the bottom view and the top view of the upper and lower component forming the upper member of the inhaling device in accordance with the invenber 31 which is formed with an upwardly extending platform, wherein a cavity 40 is provided for receiving a capsule 45 filled with a suitable medicinal powder composition.
  • the lower member 31 also contains the piercing device which is housed in the said platform as will be explained in more detail hereinafter.
  • the central top portion of the upper member 1 has supported therein a plurality of telescopically movable integral sleeve members, which upon being extended outwardly, form the mixing chamber W.
  • the component 2 is formed with trapezoidally profiled ribs 4 which define therebetween tangential passages 61 (see FIG. 6), and the component 1 (see FIG.
  • Component 1 which extend in the assembled position into the said tangential passages or gaps 61.
  • Component 1 is provided with a set of pins 3 (see FIGS. 4 and 5 which c0- operate with, and on the same transverse side of, the gaps formed by the tangential passage 61, whereby the two components 1 and 2 are precisely positioned with one another in the assembled position. Secure connection of the two components 1 and 2 is effected by the provision of suitable adhesive means at 29.
  • the mouthpiece of the inhaling device of the invention is telescopically extendable by means of sleeve members 12, 13 and 14.
  • the member 12 is formed with outlet openings 52 for the powder to be inhaled.
  • a net of plastics material is adhesively connected to the lower end of the mouthpiece 12 and operates as'a screen 53, preventing the capsule debris passing to the mouthpiece l2.
  • the component 2 is formed with a peripheral downwardly projecting skirt the inside surface of which is provided with inwardly extending profiled projections 50 which act as cams with profiled recesses 69 for actuating the piercing device P, both represented in dotted lines inFIG. 7.
  • the piercing device will be hereinafter illustrated with reference to FIGS. 4 and 7.
  • a piercing needle 8 for the capsule is'housed in a radial recess 40 of the plat-' form of the lower member 31 and is urged away from the capsule by means of a spring 9.
  • the needle terminates with a push-button 10 which co-operates with the cams 50 and recesses 69, and the said push-button 10 may be held in its maximum radially extending position by a ring 51 which is frictionally mounted around the platform of the lower member 31.
  • a plurality of knurled portions 57 may be provided in the lower member 31 of the inhaling device 30 to facilitate grasping of the device by a user.
  • two diametrally opposed piercing devices P are provided.
  • the capsule After having separated the lower member 31 from the upper member (comprising components 1 and 2) the capsule is placed in the cavity 40 provided in the upwardly extending platform of the lower member 31 thereafter the lower member 31 is frictionally secured to the upper member, by the reaction of the said springs 9 against the said skirt.
  • the cams and recesses 69 Upon relative rotational movement between the upper and lower members, the cams and recesses 69 cause a number of reciprocations of the needle 8 and, therefore a number of piercing operations of the capsule in diametrally opposed positions is effected.
  • the patient with the mouthpiece already telescopically extended causes, by aspiration, a displacement and movement of the capsule into the extended mixing or whirling chamber and, therefore, the medicinal powder composition is dispersed into the said chamber and is finally inhaled into the patients mouth. It can be seen that the powder composition traverses, prior to inhalation by the patient, the filter screen 53 and the openings 52 moulded in the central telescopic member 12.
  • An inhaling device for medicinal powder compositions provided in capsule form comprising, in combination: a disc shaped lower platform member provided with a cavity in which the said capsule is to be located, and at least one piercing member for said capsule projecting from the said platform, a spring for biasing the piercing member from said capsule and projecting it from said platform, an upper member, formed with a number of tangential passages extending from the outside to the interior thereof said upper member having a recess providing a peripheral cam shaped wall portion for actuating said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with an outwardly telescopically extendable sleeve means, including a mouth engaging portion, which when extended defines a whirling chamber for said capsule and its medicinal powder contents.
  • the upper member comprises an upper and a lower component, connected together by adhesive means and together defining the tangential passages, the upper component including a plurality of pins uniformly and radially spaced in like manner as the tangential passages and of the same size thereof, whereupon, in the assembled position, the pins co-operate with the tangential passages so that the mutual disposition of both components is exactly located before adhesively securing the two components together.

Abstract

This invention is concerned with some improvements in the inhaling devices with whirling chamber, devices that may be considered in their essential operation per se known and are intended to disperse the contents of a capsule filled with a powder medicinal composition. The invention essentially resides in the provision of a mouth piece that is of a telescopic structure and in the provision of two piercing devices that are provided into a rotatable member according to a diametral opposed position and are actuated by the member, the telescoping structure when extended forming the whirling chamber, the mantel of the latter mentioned member being formed with a cam able to give a number of piercing operations to both piercing devices.

Description

United States Patent [1 1 Cocozza Apr. 30, 1974 INHALING DEVICE FOR MEDICINAL POWDER COMPOSITIONS [75] Inventor: Salvatore Cocozza, Milano, Italy [73] Assignee: I. S. F. S.p.A., Milano, Italy [22] Filed: June 26, 1972 [21] Appl. No.: 266,243
[30] Foreign Application Priority Data July 17, 1971 Italy 26971/71 [52] US. Cl 128/266, 128/206, 128/208 [51] Int. Cl A6lm 13/00 [58] Field of Search 128/266, 206, 208, 272;
[56] References Cited UNITED STATES PATENTS 2,573,918 11/1958 McCuiston 128/206 3,507,277 4/1970 Altounyan et a1. 128/208 3,518,992 7/1970 Altounyan et a1. 128/208 3,635,219 1/1972 Altounyan et al. 128/266 3,669,113 6/1972 Altounyan et a1. 128/266 FOREIGN PATENTS OR APPLICATIONS 208,211 12/1967 U.S.S.R 128/266 Primary ExaminerAldrich F. Medbery Attorney, Agent, or Firm--Eric H. Waters [57] ABSTRACT This invention is concerned with some improvements in the inhaling devices with whirling chamber, devices that may be considered in their essential operation per se known and are intended to disperse the contents of a capsule filled with a powder medicinal composition,
'number of piercing operations to both piercing devices.
2 Claims, 7 Drawing Figures INHALING DEVICE FOR MEDICINAL POWDER COMPOSITIONS FIELD OF THE INVENTION The present invention relates to improvements in or modifications of inhaling devices for'medicinal powder compositions in capsule form.
SUMMARY OF THE INVENTION It is an object of the present invention to provide an inhaling device of economical construction, of high efficiency which is able to be used by any category of patients and for any kind of powder compositions contained in capsules.
It is a further object of the present invention to provide a compact inhaling device of substantially reduced overall dimension as compared with known devices for use with medicinal powder composition capsule form.
According to the present invention, there is provided an inhaling device for medicinal powder compositions provided in capsule form comprising, in combination, a disc-shaped lower member provided with a cavity in which the said capsule is to be located, which cavity is formed in an upwardly extending platform of said member, and at least one piercing member for said capsule, which piercing member is resiliently biased away from said capsule and projects from said platform, an upper member formed with a number of tangential passages, said upper member providing a lower edge to provide a cam which is able to reciprocate said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with a telescopically extendable mouthpiece, whirling chamher being defined in the region of the extended mouthpiece.
BRIEF DESCRIPTION OF THE DRAWINGS The invention will be further illustrated, by way of example, with reference to the accompanying drawings, in which: I
FIG. 1 is a side view of an inhaling device in accordance with the invention in its inactive or retracted position;
FIG. 2 is a side view of an inhaling device in accordance with the invention in it active or operative position;
FIG. 3 is a top plan view of the inhaling device shown in FIGS. 1 and 2;
FIG. 4 is a radial partial sectional view of the inhaling device of the invention;
FIGS. 5 and 6, on the same scale as FIG. 1, are respectively the bottom view and the top view of the upper and lower component forming the upper member of the inhaling device in accordance with the invenber 31 which is formed with an upwardly extending platform, wherein a cavity 40 is provided for receiving a capsule 45 filled with a suitable medicinal powder composition. The lower member 31 also contains the piercing device which is housed in the said platform as will be explained in more detail hereinafter.
"ll'teupper member comprising two components 1 and 2, together with the lower member 31 forms a mixing chamber W for the contents of the pierced capsule, which are subjected to a whirling action therein.
The central top portion of the upper member 1 has supported therein a plurality of telescopically movable integral sleeve members, which upon being extended outwardly, form the mixing chamber W.
The component 2 is formed with trapezoidally profiled ribs 4 which define therebetween tangential passages 61 (see FIG. 6), and the component 1 (see FIG.
which extend in the assembled position into the said tangential passages or gaps 61. Component 1 is provided with a set of pins 3 (see FIGS. 4 and 5 which c0- operate with, and on the same transverse side of, the gaps formed by the tangential passage 61, whereby the two components 1 and 2 are precisely positioned with one another in the assembled position. Secure connection of the two components 1 and 2 is effected by the provision of suitable adhesive means at 29.
In operation, the mouthpiece of the inhaling device of the invention is telescopically extendable by means of sleeve members 12, 13 and 14. The member 12 is formed with outlet openings 52 for the powder to be inhaled. A net of plastics material is adhesively connected to the lower end of the mouthpiece 12 and operates as'a screen 53, preventing the capsule debris passing to the mouthpiece l2.
The component 2 is formed with a peripheral downwardly projecting skirt the inside surface of which is provided with inwardly extending profiled projections 50 which act as cams with profiled recesses 69 for actuating the piercing device P, both represented in dotted lines inFIG. 7. The piercing device will be hereinafter illustrated with reference to FIGS. 4 and 7. A piercing needle 8 for the capsule is'housed in a radial recess 40 of the plat-' form of the lower member 31 and is urged away from the capsule by means of a spring 9. The needle terminates with a push-button 10 which co-operates with the cams 50 and recesses 69, and the said push-button 10 may be held in its maximum radially extending position by a ring 51 which is frictionally mounted around the platform of the lower member 31.
A plurality of knurled portions 57 may be provided in the lower member 31 of the inhaling device 30 to facilitate grasping of the device by a user.
In order to obtain two diametrally opposed perforations in the capsule 45, two diametrally opposed piercing devices P are provided.
Operation of the inhaling device of the invention is as follows:
After having separated the lower member 31 from the upper member (comprising components 1 and 2) the capsule is placed in the cavity 40 provided in the upwardly extending platform of the lower member 31 thereafter the lower member 31 is frictionally secured to the upper member, by the reaction of the said springs 9 against the said skirt. Upon relative rotational movement between the upper and lower members, the cams and recesses 69 cause a number of reciprocations of the needle 8 and, therefore a number of piercing operations of the capsule in diametrally opposed positions is effected. The patient, with the mouthpiece already telescopically extended causes, by aspiration, a displacement and movement of the capsule into the extended mixing or whirling chamber and, therefore, the medicinal powder composition is dispersed into the said chamber and is finally inhaled into the patients mouth. It can be seen that the powder composition traverses, prior to inhalation by the patient, the filter screen 53 and the openings 52 moulded in the central telescopic member 12.
The preceding description makes it evident that the mentioned objects of the invention have been fully attained. In the light of the disclosure changes and modifications within the true spirit and scope of the invention will occur to others, and accordingly it is not desired that the scope of the invention be restricted except as is required by the appended claims.
What I claim is:
1. An inhaling device for medicinal powder compositions provided in capsule form comprising, in combination: a disc shaped lower platform member provided with a cavity in which the said capsule is to be located, and at least one piercing member for said capsule projecting from the said platform, a spring for biasing the piercing member from said capsule and projecting it from said platform, an upper member, formed with a number of tangential passages extending from the outside to the interior thereof said upper member having a recess providing a peripheral cam shaped wall portion for actuating said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with an outwardly telescopically extendable sleeve means, including a mouth engaging portion, which when extended defines a whirling chamber for said capsule and its medicinal powder contents.
2. An inhaling device as claimed in claim 1, in which the upper member comprises an upper and a lower component, connected together by adhesive means and together defining the tangential passages, the upper component including a plurality of pins uniformly and radially spaced in like manner as the tangential passages and of the same size thereof, whereupon, in the assembled position, the pins co-operate with the tangential passages so that the mutual disposition of both components is exactly located before adhesively securing the two components together.

Claims (2)

1. An inhaling device for medicinal powder compositions provided in capsule form comprising, in combination: a disc shaped lower platform member provided with a cavity in which the said capsule is to be located, and at least one piercing member for said capsule projecting from the said platform, a spring for biasing the piercing member from said capsule and projecting it from said platform, an upper member, formed with a number of tangential passages extending from the outside to the interior thereof said upper member having a recess providing a peripheral cam shaped wall portion for actuating said piercing member against the action of a spring in order to pierce said capsule, the upper member being provided with an outwardly telescopically extendable sleeve means, including a mouth engaging portion, which when extended defines a whirling chamber for said capsule and its medicinal powder contents.
2. An inhaling device as claimed in claim 1, in which the upper member comprises an upper and a lower component, connected together by adhesive means and together defining the tangential passages, the upper component including a plurality of pins uniformly and radially spaced in like manner as the tangential passages and of the same size thereof, whereupon, in the assembled position, the pins co-operate with the tangential passages so that the mutual disposition of both components is exactly located before adhesively securing the two components together.
US00266243A 1971-07-17 1972-06-26 Inhaling device for medicinal powder compositions Expired - Lifetime US3807400A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT26971/71A IT941426B (en) 1971-07-17 1971-07-17 SWIRL-CHAMBER INHALER FOR POWDER-SHAPING MEDICINAL SUBSTANCES

Publications (1)

Publication Number Publication Date
US3807400A true US3807400A (en) 1974-04-30

Family

ID=11220655

Family Applications (1)

Application Number Title Priority Date Filing Date
US00266243A Expired - Lifetime US3807400A (en) 1971-07-17 1972-06-26 Inhaling device for medicinal powder compositions

Country Status (10)

Country Link
US (1) US3807400A (en)
AT (1) AT333415B (en)
BE (1) BE781102A (en)
CA (1) CA999202A (en)
CH (1) CH563167A5 (en)
ES (1) ES208808Y (en)
FR (1) FR2146202B1 (en)
GB (1) GB1331216A (en)
IT (1) IT941426B (en)
NL (1) NL7305363A (en)

Cited By (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3858583A (en) * 1973-02-26 1975-01-07 Allen & Hanburys Ltd Medicament inhalation device
US3870046A (en) * 1973-05-08 1975-03-11 Miles Lab Insufflator
US3938516A (en) * 1975-01-13 1976-02-17 Syntex Puerto Rico, Inc. Inhalation device
US3948264A (en) * 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
US3964483A (en) * 1975-01-13 1976-06-22 Syntex Puerto Rico, Inc. Inhalation device
US3973566A (en) * 1975-01-13 1976-08-10 Syntex Puerto Rico Inc. Inhalation device
US3991761A (en) * 1974-03-18 1976-11-16 Salvatore Cocozza Inhaler for powdered medicaments
US4014336A (en) * 1975-01-13 1977-03-29 Syntex Puerto Rico, Inc. Inhalation device
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US4095596A (en) * 1976-11-26 1978-06-20 Smithkline Corporation Nasal inhaler
US4155359A (en) * 1977-05-23 1979-05-22 Antoni Zagorski Air filtering mask
US4249526A (en) * 1978-05-03 1981-02-10 Fisons Limited Inhalation device
EP0041783A1 (en) * 1980-06-06 1981-12-16 FISONS plc Inhalation device for powdered medicaments
DK154399B (en) * 1976-02-10 1988-11-14 Allen & Hanburys Ltd inhaler
US4884565A (en) * 1987-08-17 1989-12-05 Miat S.P.A. Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5207217A (en) * 1990-07-16 1993-05-04 Promo Pack Sa Multiple single-dose inhaler for medicaments in powder form
US5331953A (en) * 1989-03-07 1994-07-26 Aktiebolaget Draco Device in connection with an inhaler
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
US5522383A (en) * 1990-06-14 1996-06-04 Rhone-Poulenc Rorer Ltd. Powder inhaler having capsule holding structure and anti-static walls
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US5676130A (en) * 1992-03-19 1997-10-14 Boehringer Ingelheim Gmbh, Inc. Separator for powdered inhalers
US5692496A (en) * 1995-08-02 1997-12-02 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5823183A (en) * 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
WO1999064095A2 (en) 1998-06-12 1999-12-16 Microdose Technologies, Inc. Metering, packaging and delivery of pharmaceuticals and drugs
US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
US6209538B1 (en) * 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
WO2001062342A1 (en) * 2000-02-24 2001-08-30 Irm Technologies Pty Ltd Nasal filter and sampler
EP1204437A1 (en) * 1999-07-20 2002-05-15 Thayer Medical Corporation Collapsible, disposable mdi spacer and method
US20020134382A1 (en) * 2000-05-10 2002-09-26 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
US20030047184A1 (en) * 2001-01-12 2003-03-13 Lockhart Artis R. Medicament respiratory delivery device
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
US20040149283A1 (en) * 2002-12-12 2004-08-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
US20040163645A1 (en) * 2001-01-12 2004-08-26 Connelly Robert I. Medicament inhalation delivery devices and methods for using the same
US6792945B2 (en) * 1990-03-02 2004-09-21 Glaxo Group Limited Inhalation device
US20040237961A1 (en) * 1995-06-08 2004-12-02 Snow John Medlin Inhalation actuated device for use with metered dose inhalers (MDIs)
US20050126568A1 (en) * 1990-03-02 2005-06-16 Davies Michael B. Inhalation device
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
US20050172962A1 (en) * 2004-02-06 2005-08-11 Microdose Technologies, Inc. Blister pack for use with an inhalation device
US20050183725A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Directional flow sensor inhaler
US20050183724A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
WO2006051300A1 (en) * 2004-11-10 2006-05-18 Cipla Limited Inhaler
US20060157054A1 (en) * 2005-01-11 2006-07-20 Boehringer Lngelheim Pharma Gmbh & Co. Kg Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US20070107722A1 (en) * 2005-11-15 2007-05-17 Hubert Hoelz Needle for piercing a powder capsule for inhalation
US20070209661A1 (en) * 2006-03-03 2007-09-13 Hugh Smyth Dry powder inhaler with aeroelastic dispersion mechanism
WO2007107160A1 (en) 2006-03-21 2007-09-27 Bang & Olufsen Medicom A/S Inhaler flow channel
US20070240713A1 (en) * 2006-04-11 2007-10-18 Georg Boeck Inhaler
US20070240712A1 (en) * 2006-04-05 2007-10-18 Scott Fleming Variable dose inhalation device
US20080160076A1 (en) * 1998-08-05 2008-07-03 Dieter Hochrainer Two-part capsule to accept pharmaceutical preparations for powder inhalers
US20080163610A1 (en) * 2007-01-05 2008-07-10 Matthew Thomas Baird Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle
US20080295832A1 (en) * 2005-10-28 2008-12-04 Johannes Geser Inhaler with Mouthpiece Having a Microbiological Protective Function
US20080308103A1 (en) * 2005-05-18 2008-12-18 Airsec S.A.S. Inhalator Capsules
EP2020249A1 (en) * 2007-08-01 2009-02-04 Boehringer Ingelheim Pharma GmbH & Co. KG Inhalator
US20090090361A1 (en) * 2007-10-09 2009-04-09 Anand Gumaste Inhalation device
US20090217925A1 (en) * 2008-02-29 2009-09-03 Anand Gumaste Method and apparatus for driving a transducer of an inhalation device
WO2009139732A1 (en) * 2008-05-16 2009-11-19 Bilgic Mahmut Dry powder inhaler
US20090320838A1 (en) * 2006-06-16 2009-12-31 Cipla Limited Dry powder inhaler
US20100040560A1 (en) * 2005-05-18 2010-02-18 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20100087416A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US20100087386A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Topical use of levofloxacin for reducing lung inflammation
US20100294278A1 (en) * 2009-05-21 2010-11-25 Mosier Kent D Rotary cassette system for dry powder inhaler
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US20110000482A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Laboratory animal pulmonary dosing device
US20110056488A1 (en) * 2008-01-24 2011-03-10 Vectura Delivery Devices Limited Inhaler
US20110162642A1 (en) * 2010-01-05 2011-07-07 Akouka Henri M Inhalation device and method
EP2357015A2 (en) 2006-04-05 2011-08-17 MicroDose Therapeutx, Inc. Variable dose inhalation device
EP2594272A2 (en) 2005-05-18 2013-05-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
US8748488B2 (en) 2008-05-30 2014-06-10 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
WO2015075433A1 (en) 2013-11-19 2015-05-28 Cipla Limited Inhaler device
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
WO2015128789A1 (en) 2014-02-25 2015-09-03 Lupin Limited Inhaler
WO2015143012A1 (en) 2014-03-19 2015-09-24 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2015179369A1 (en) 2014-05-20 2015-11-26 Infinity Pharmaceuticals, Inc. Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors
WO2016007356A1 (en) 2014-07-07 2016-01-14 Microdose Therapeutx, Inc. Inhalation device
WO2016014154A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder nebulizer
WO2016014586A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder medicament de-agglomerator
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
US20170095625A1 (en) * 2014-06-04 2017-04-06 Merck Sharp & Dohme Corp. Dry powder inhaler with dose depletion evaluation
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10028966B2 (en) 2014-01-10 2018-07-24 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US10238821B2 (en) 2016-10-11 2019-03-26 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
US10441733B2 (en) 2012-06-25 2019-10-15 Respira Therapeutics, Inc. Powder dispersion devices and methods
US20200139057A1 (en) * 2017-06-27 2020-05-07 Korea United Pharm. Inc. Dry powder inhaler
EP3782604A1 (en) 2013-07-31 2021-02-24 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
US11224704B2 (en) * 2007-07-06 2022-01-18 Manta Devices, Llc Dose delivery device for inhalation
EP4059499A1 (en) 2011-01-31 2022-09-21 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US11471623B2 (en) 2012-02-21 2022-10-18 Respira Therapeutics, Inc. Powder dispersion methods and devices
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1404338A (en) * 1972-08-04 1975-08-28 Beecham Group Ltd Device for the inhalation of medicaments
DE2346914C3 (en) * 1973-09-18 1980-10-16 Paul Ritzau Pari-Werk, Gmbh & Co, 8130 Starnberg Powdered substance inhaler
DE3050005A1 (en) * 1979-10-30 1982-03-18 Riker Laboratories Inc BREATH ACTUATED DEVICES FOR ADMINISTERING POWDERED MEDICAMENTS
ES506585A0 (en) * 1980-10-30 1982-09-01 Riker Laboratories Inc A DEVICE TO FACILITATE THE ORAL INHALATION OF MEDICINES IN THE FORM OF POWDER
US6536427B2 (en) 1990-03-02 2003-03-25 Glaxo Group Limited Inhalation device
GB9004781D0 (en) * 1990-03-02 1990-04-25 Glaxo Group Ltd Device
GB2253200A (en) * 1991-02-01 1992-09-02 Harris Pharma Ltd Inhalation apparatus and fracturable capsule for use therewith
US5476093A (en) * 1992-02-14 1995-12-19 Huhtamaki Oy Device for more effective pulverization of a powdered inhalation medicament
DE4239402A1 (en) * 1992-11-24 1994-05-26 Bayer Ag Multiple dosage powder inhaler - has acceleration channel and dwell chamber for uniformly high drug dispersion
CA2212430A1 (en) 1997-08-07 1999-02-07 George Volgyesi Inhalation device
DE10258360A1 (en) 2002-12-12 2004-06-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg Chamber for accommodation of disposable capsules for powder inhalers has an inner surface with protruding elements serving as distance pieces between the capsules
DE102006016901A1 (en) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Mouthpiece for an inhaler
DE102006016904A1 (en) 2006-04-11 2007-10-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg inhaler
WO2008089150A2 (en) 2007-01-12 2008-07-24 Opex Corporation Method and apparatus for sorting items
DE102007033860A1 (en) 2007-07-20 2009-01-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Test arrangement for testing sealing between mouthpiece of inhaler and user's lips has channel for secondary air around user's lips with second flow measurement device
DE102007052871A1 (en) 2007-11-02 2009-05-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Capsule for receiving pharmaceutical drug formulations
DE202008015493U1 (en) 2008-11-21 2009-02-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg folding

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU208211A1 (en) * А. С. Пономарев
US2573918A (en) * 1949-11-05 1951-11-06 Vick Chemical Company Device for dispensing medicaments
US3507277A (en) * 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device
US3518992A (en) * 1966-09-17 1970-07-07 Fisons Pharmaceuticals Ltd Oral inhaler with spring biased,cam driven piercing device
US3635219A (en) * 1968-06-07 1972-01-18 Fisons Pharmaceuticals Ltd Inhalation device
US3669113A (en) * 1966-03-07 1972-06-13 Fisons Ltd Inhalation device

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU208211A1 (en) * А. С. Пономарев
US2573918A (en) * 1949-11-05 1951-11-06 Vick Chemical Company Device for dispensing medicaments
US3669113A (en) * 1966-03-07 1972-06-13 Fisons Ltd Inhalation device
US3507277A (en) * 1966-09-17 1970-04-21 Fisons Pharmaceuticals Ltd Inhalation device
US3518992A (en) * 1966-09-17 1970-07-07 Fisons Pharmaceuticals Ltd Oral inhaler with spring biased,cam driven piercing device
US3635219A (en) * 1968-06-07 1972-01-18 Fisons Pharmaceuticals Ltd Inhalation device

Cited By (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3858583A (en) * 1973-02-26 1975-01-07 Allen & Hanburys Ltd Medicament inhalation device
US4069819A (en) * 1973-04-13 1978-01-24 Societa Farmaceutici S.P.A. Inhalation device
US3870046A (en) * 1973-05-08 1975-03-11 Miles Lab Insufflator
US3991761A (en) * 1974-03-18 1976-11-16 Salvatore Cocozza Inhaler for powdered medicaments
US3938516A (en) * 1975-01-13 1976-02-17 Syntex Puerto Rico, Inc. Inhalation device
US3964483A (en) * 1975-01-13 1976-06-22 Syntex Puerto Rico, Inc. Inhalation device
US3973566A (en) * 1975-01-13 1976-08-10 Syntex Puerto Rico Inc. Inhalation device
US4014336A (en) * 1975-01-13 1977-03-29 Syntex Puerto Rico, Inc. Inhalation device
US3948264A (en) * 1975-05-21 1976-04-06 Mead Johnson & Company Inhalation device
DK154399B (en) * 1976-02-10 1988-11-14 Allen & Hanburys Ltd inhaler
US4095596A (en) * 1976-11-26 1978-06-20 Smithkline Corporation Nasal inhaler
US4155359A (en) * 1977-05-23 1979-05-22 Antoni Zagorski Air filtering mask
US4249526A (en) * 1978-05-03 1981-02-10 Fisons Limited Inhalation device
EP0041783A1 (en) * 1980-06-06 1981-12-16 FISONS plc Inhalation device for powdered medicaments
US4884565A (en) * 1987-08-17 1989-12-05 Miat S.P.A. Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola
US5331953A (en) * 1989-03-07 1994-07-26 Aktiebolaget Draco Device in connection with an inhaler
US6048857A (en) * 1989-10-17 2000-04-11 Ellinwood, Jr.; Everett H. Dosing method of administering medicaments via inhalation administration
US20070107724A9 (en) * 1990-03-02 2007-05-17 Davies Michael B Inhalation device
US6792945B2 (en) * 1990-03-02 2004-09-21 Glaxo Group Limited Inhalation device
US7389775B2 (en) 1990-03-02 2008-06-24 Glaxo Group Limited Inhalation device
US20050126568A1 (en) * 1990-03-02 2005-06-16 Davies Michael B. Inhalation device
US7225808B2 (en) 1990-03-02 2007-06-05 Glaxo Group Limited Inhalation device
US5522383A (en) * 1990-06-14 1996-06-04 Rhone-Poulenc Rorer Ltd. Powder inhaler having capsule holding structure and anti-static walls
US5207217A (en) * 1990-07-16 1993-05-04 Promo Pack Sa Multiple single-dose inhaler for medicaments in powder form
US5161524A (en) * 1991-08-02 1992-11-10 Glaxo Inc. Dosage inhalator with air flow velocity regulating means
US5676130A (en) * 1992-03-19 1997-10-14 Boehringer Ingelheim Gmbh, Inc. Separator for powdered inhalers
US5460173A (en) * 1993-03-03 1995-10-24 Tenax Corporation Dry powder inhaler medicament carrier
US5388572A (en) * 1993-10-26 1995-02-14 Tenax Corporation (A Connecticut Corp.) Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same
US5388573A (en) * 1993-12-02 1995-02-14 Tenax Corporation Dry powder inhalator medicament carrier
US20040237961A1 (en) * 1995-06-08 2004-12-02 Snow John Medlin Inhalation actuated device for use with metered dose inhalers (MDIs)
US6729324B2 (en) 1995-06-08 2004-05-04 Innovative Devices, Llc. Inhalation actuated device for use with metered dose inhalers (MDIs)
US6672304B1 (en) 1995-06-08 2004-01-06 Innovative Devices, Llc Inhalation actuated device for use with metered dose inhalers (MDIs)
US6561186B2 (en) 1995-08-02 2003-05-13 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5988163A (en) * 1995-08-02 1999-11-23 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament
US5823183A (en) * 1995-08-02 1998-10-20 Innovative Devices Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6209538B1 (en) * 1995-08-02 2001-04-03 Robert A. Casper Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5692496A (en) * 1995-08-02 1997-12-02 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US6550477B1 (en) 1995-08-02 2003-04-22 Innovative Devices, Llc Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament
US5669378A (en) * 1995-12-21 1997-09-23 Pera; Ivo Inhaling device
US6152130A (en) * 1998-06-12 2000-11-28 Microdose Technologies, Inc. Inhalation device with acoustic control
WO1999064095A2 (en) 1998-06-12 1999-12-16 Microdose Technologies, Inc. Metering, packaging and delivery of pharmaceuticals and drugs
US6142146A (en) * 1998-06-12 2000-11-07 Microdose Technologies, Inc. Inhalation device
US8298575B2 (en) 1998-08-05 2012-10-30 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-part capsule to accept pharmaceutical preparations for powder inhalers
US20080160076A1 (en) * 1998-08-05 2008-07-03 Dieter Hochrainer Two-part capsule to accept pharmaceutical preparations for powder inhalers
US6237591B1 (en) 1998-11-02 2001-05-29 Dura Pharmaceuticals, Inc. Turbine dry powder inhaler
EP1204437A4 (en) * 1999-07-20 2003-01-22 Thayer Medical Corp Collapsible, disposable mdi spacer and method
EP1204437A1 (en) * 1999-07-20 2002-05-15 Thayer Medical Corporation Collapsible, disposable mdi spacer and method
WO2001062342A1 (en) * 2000-02-24 2001-08-30 Irm Technologies Pty Ltd Nasal filter and sampler
US20030106555A1 (en) * 2000-02-24 2003-06-12 Euan Tovey Nasal filter and sampler
EP1941868A2 (en) 2000-02-28 2008-07-09 PharmaKodex Limited Improvements in or relating to the delivery of oral drugs
US20050158394A1 (en) * 2000-02-28 2005-07-21 Vectura Limited Delivery of oral drugs
US20050056281A1 (en) * 2000-05-10 2005-03-17 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
US6948494B1 (en) 2000-05-10 2005-09-27 Innovative Devices, Llc. Medicament container with same side airflow inlet and outlet and method of use
US7318436B2 (en) 2000-05-10 2008-01-15 Innovative Devices, Llc Medicament container with same side airflow inlet and outlet and method of use
US20020134382A1 (en) * 2000-05-10 2002-09-26 Snow John M. Medicament container with same side airflow inlet and outlet and method of use
US8573202B2 (en) 2000-06-28 2013-11-05 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
US7810495B2 (en) 2000-06-28 2010-10-12 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
US20090314288A1 (en) * 2000-06-28 2009-12-24 Gumaste Anand V Packaging and delivery of pharmaceuticals and drugs
US20110030679A1 (en) * 2000-06-28 2011-02-10 Gumaste Anand V Packaging and delivery of pharmaceuticals and drugs
US7080644B2 (en) 2000-06-28 2006-07-25 Microdose Technologies, Inc. Packaging and delivery of pharmaceuticals and drugs
US7950390B2 (en) 2000-06-28 2011-05-31 Microdose Therapeutx, Inc. Packaging and delivery of pharmaceuticals and drugs
US20060237011A1 (en) * 2000-06-28 2006-10-26 Gumaste Anand V Packaging and delivery of pharmaceuticals and drugs
US20040163645A1 (en) * 2001-01-12 2004-08-26 Connelly Robert I. Medicament inhalation delivery devices and methods for using the same
US20080006269A1 (en) * 2001-01-12 2008-01-10 Lockhart Artis R Medicament Respiratory Delivery Device
US7270127B2 (en) 2001-01-12 2007-09-18 Becton, Dickinson And Company Medicament respiratory delivery device
US20030047184A1 (en) * 2001-01-12 2003-03-13 Lockhart Artis R. Medicament respiratory delivery device
US7040316B2 (en) * 2001-01-12 2006-05-09 Becton, Dickinson And Company Medicament inhalation delivery devices and methods for using the same
US20040149283A1 (en) * 2002-12-12 2004-08-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
US7284553B2 (en) 2002-12-12 2007-10-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient
US20050172962A1 (en) * 2004-02-06 2005-08-11 Microdose Technologies, Inc. Blister pack for use with an inhalation device
US20050183724A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20060174869A1 (en) * 2004-02-24 2006-08-10 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US9764104B2 (en) 2004-02-24 2017-09-19 Microdose Therapeutx, Inc. Directional flow sensor inhaler
US7334577B2 (en) 2004-02-24 2008-02-26 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20050183725A1 (en) * 2004-02-24 2005-08-25 Microdose Technologies, Inc. Directional flow sensor inhaler
US20080115784A1 (en) * 2004-02-24 2008-05-22 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
US8322338B2 (en) 2004-02-24 2012-12-04 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US8474452B2 (en) 2004-02-24 2013-07-02 Microdose Therapeutx, Inc. Directional flow sensor inhaler
US7779837B2 (en) 2004-02-24 2010-08-24 Microdose Therapeutx, Inc. Synthetic jet based medicament delivery method and apparatus
US7318434B2 (en) 2004-02-24 2008-01-15 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US20100229860A1 (en) * 2004-02-24 2010-09-16 Gumaste Anand V Synthetic jet based medicament delivery method and apparatus
WO2005081833A2 (en) 2004-02-24 2005-09-09 Microdose Technologies, Inc. Synthetic jet based medicament delivery method and apparatus
US9162031B2 (en) 2004-02-24 2015-10-20 Microdose Therapeutx, Inc. Directional flow sensor inhaler
EA010922B1 (en) * 2004-11-10 2008-12-30 Сипла Лимитед Inhaler
WO2006051300A1 (en) * 2004-11-10 2006-05-18 Cipla Limited Inhaler
US20080105256A1 (en) * 2004-11-10 2008-05-08 Cipla Limited Inhaler
US8006695B2 (en) 2004-11-10 2011-08-30 Cipla Limited Inhaler
US20060157054A1 (en) * 2005-01-11 2006-07-20 Boehringer Lngelheim Pharma Gmbh & Co. Kg Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers
US8662076B2 (en) 2005-01-11 2014-03-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers
US20080308103A1 (en) * 2005-05-18 2008-12-18 Airsec S.A.S. Inhalator Capsules
EP2594272A2 (en) 2005-05-18 2013-05-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20100040560A1 (en) * 2005-05-18 2010-02-18 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20100037890A1 (en) * 2005-05-18 2010-02-18 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US10987357B2 (en) 2005-05-18 2021-04-27 Horizon Orphan, LLC Aerosolized fluoroquinolones and uses thereof
US8357696B2 (en) 2005-05-18 2013-01-22 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20100158957A1 (en) * 2005-05-18 2010-06-24 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20100166673A1 (en) * 2005-05-18 2010-07-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524735B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US8524734B2 (en) 2005-05-18 2013-09-03 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
US20080295832A1 (en) * 2005-10-28 2008-12-04 Johannes Geser Inhaler with Mouthpiece Having a Microbiological Protective Function
US8397717B2 (en) 2005-10-28 2013-03-19 Boehringer Ingelheim International Gmbh Inhaler with mouthpiece having a microbiological protective function
US9604017B2 (en) 2005-11-15 2017-03-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Needle for piercing a powder capsule for inhalation
US20070107722A1 (en) * 2005-11-15 2007-05-17 Hubert Hoelz Needle for piercing a powder capsule for inhalation
US20070209661A1 (en) * 2006-03-03 2007-09-13 Hugh Smyth Dry powder inhaler with aeroelastic dispersion mechanism
WO2007107160A1 (en) 2006-03-21 2007-09-27 Bang & Olufsen Medicom A/S Inhaler flow channel
EP2357015A2 (en) 2006-04-05 2011-08-17 MicroDose Therapeutx, Inc. Variable dose inhalation device
US20070240712A1 (en) * 2006-04-05 2007-10-18 Scott Fleming Variable dose inhalation device
US7870856B2 (en) 2006-04-11 2011-01-18 Boehringer Ingelheim International Gmbh Inhaler
US20070240713A1 (en) * 2006-04-11 2007-10-18 Georg Boeck Inhaler
US8522775B2 (en) * 2006-06-16 2013-09-03 Cipla Limited Dry powder inhaler
US20090320838A1 (en) * 2006-06-16 2009-12-31 Cipla Limited Dry powder inhaler
US20080163610A1 (en) * 2007-01-05 2008-07-10 Matthew Thomas Baird Method and system for regenerating exhaust system filtering and catalyst components using variable high engine idle
US11224704B2 (en) * 2007-07-06 2022-01-18 Manta Devices, Llc Dose delivery device for inhalation
WO2009016238A2 (en) * 2007-08-01 2009-02-05 Boehringer Ingelhelheim International Gmbh Inhaler
CN101815552B (en) * 2007-08-01 2013-03-06 贝林格尔.英格海姆国际有限公司 Inhaler
RU2470680C2 (en) * 2007-08-01 2012-12-27 Берингер Ингельхайм Интернациональ Гмбх Inhaler
EP2020249A1 (en) * 2007-08-01 2009-02-04 Boehringer Ingelheim Pharma GmbH & Co. KG Inhalator
US20100313886A1 (en) * 2007-08-01 2010-12-16 Herbert Wachtel Inhaler
US8919342B2 (en) 2007-08-01 2014-12-30 Boehringer Ingelheim International Gmbh Inhaler
WO2009016238A3 (en) * 2007-08-01 2009-05-07 Boehringer Ingelhelheim Intern Inhaler
US8439033B2 (en) 2007-10-09 2013-05-14 Microdose Therapeutx, Inc. Inhalation device
US9132246B2 (en) 2007-10-09 2015-09-15 Microdose Therapeutx, Inc. Inhalation device
US9539400B2 (en) 2007-10-09 2017-01-10 Microdose Therapeutx, Inc. Inhalation device
US20090090361A1 (en) * 2007-10-09 2009-04-09 Anand Gumaste Inhalation device
US9125998B2 (en) 2008-01-24 2015-09-08 Vectura Delivery Devices Limited Inhaler
US20110056488A1 (en) * 2008-01-24 2011-03-10 Vectura Delivery Devices Limited Inhaler
US20090217925A1 (en) * 2008-02-29 2009-09-03 Anand Gumaste Method and apparatus for driving a transducer of an inhalation device
US8371294B2 (en) 2008-02-29 2013-02-12 Microdose Therapeutx, Inc. Method and apparatus for driving a transducer of an inhalation device
WO2009139732A1 (en) * 2008-05-16 2009-11-19 Bilgic Mahmut Dry powder inhaler
US8748488B2 (en) 2008-05-30 2014-06-10 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US9119777B2 (en) 2008-05-30 2015-09-01 Microdose Therapeutx, Inc. Methods and compositions for administration of oxybutynin
US20100087416A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8815838B2 (en) 2008-10-07 2014-08-26 David C. Griffith Aerosol fluoroquinolone formulations for improved pharmacokinetics
US11020481B2 (en) 2008-10-07 2021-06-01 Horizon Orphan Llc Topical use of levofloxacin for reducing lung inflammation
US10149854B2 (en) 2008-10-07 2018-12-11 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US9326936B2 (en) 2008-10-07 2016-05-03 Raptor Pharmaceuticals, Inc. Aerosol fluoroquinolone formulations for improved pharmacokinetics
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
US10722519B2 (en) 2008-10-07 2020-07-28 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US9717738B2 (en) 2008-10-07 2017-08-01 Horizon Orphan Llc Aerosol fluoroquinolone formulations for improved pharmacokinetics
US20100087386A1 (en) * 2008-10-07 2010-04-08 Mpex Pharmaceuticals, Inc. Topical use of levofloxacin for reducing lung inflammation
US8985101B2 (en) 2009-05-21 2015-03-24 Microdose Therapeutx, Inc. Method and device for clamping a blister within a dry powder inhaler
US8763606B2 (en) 2009-05-21 2014-07-01 Microdose Therapeutx, Inc. Rotary cassette system for dry powder inhaler
US20100294278A1 (en) * 2009-05-21 2010-11-25 Mosier Kent D Rotary cassette system for dry powder inhaler
US9180263B2 (en) 2009-07-01 2015-11-10 Microdose Therapeutx, Inc. Laboratory animal pulmonary dosing device
US20110000482A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Laboratory animal pulmonary dosing device
US20110000481A1 (en) * 2009-07-01 2011-01-06 Anand Gumaste Nebulizer for infants and respiratory compromised patients
US10231975B2 (en) 2009-09-04 2019-03-19 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US9700564B2 (en) 2009-09-04 2017-07-11 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US10792289B2 (en) 2009-09-04 2020-10-06 Horizon Orphan Llc Use of aerosolized levofloxacin for treating cystic fibrosis
US9492625B2 (en) 2009-11-12 2016-11-15 Stc.Unm Dry powder inhaler with flutter dispersion member
US20110162642A1 (en) * 2010-01-05 2011-07-07 Akouka Henri M Inhalation device and method
US9974909B2 (en) 2010-01-05 2018-05-22 Microdose Therapeutx, Inc. Inhalation device and method
EP3431128A1 (en) 2010-01-05 2019-01-23 MicroDose Therapeutx, Inc. Inhalation device and method
US8991390B2 (en) 2010-01-05 2015-03-31 Microdose Therapeutx, Inc. Inhalation device and method
US10434267B2 (en) 2010-01-05 2019-10-08 Microdose Therapeutx, Inc. Inhalation device and method
US8561609B2 (en) 2010-12-07 2013-10-22 Respira Therapeutics, Inc. Dry powder inhaler
US8651104B2 (en) 2010-12-07 2014-02-18 Respira Therapeutics, Inc. Bead-containing dry powder inhaler
EP4059499A1 (en) 2011-01-31 2022-09-21 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US11471623B2 (en) 2012-02-21 2022-10-18 Respira Therapeutics, Inc. Powder dispersion methods and devices
US10441733B2 (en) 2012-06-25 2019-10-15 Respira Therapeutics, Inc. Powder dispersion devices and methods
EP3782604A1 (en) 2013-07-31 2021-02-24 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
WO2015075433A1 (en) 2013-11-19 2015-05-28 Cipla Limited Inhaler device
US10028966B2 (en) 2014-01-10 2018-07-24 Avalyn Pharma Inc. Aerosol pirfenidone and pyridone analog compounds and uses thereof
US10556069B2 (en) 2014-02-25 2020-02-11 Lupin Limited Inhaler
WO2015128789A1 (en) 2014-02-25 2015-09-03 Lupin Limited Inhaler
WO2015143012A1 (en) 2014-03-19 2015-09-24 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
EP4066834A1 (en) 2014-03-19 2022-10-05 Infinity Pharmaceuticals, Inc. Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
WO2015179369A1 (en) 2014-05-20 2015-11-26 Infinity Pharmaceuticals, Inc. Treatment of pulmonary or respiratory diseases by inhalation administration of pi3 kinase inhibitors
US20170095625A1 (en) * 2014-06-04 2017-04-06 Merck Sharp & Dohme Corp. Dry powder inhaler with dose depletion evaluation
US10744278B2 (en) 2014-07-07 2020-08-18 Microdose Therapeutx, Inc. Inhalation device
EP3804794A1 (en) 2014-07-07 2021-04-14 MicroDose Therapeutx, Inc. Inhalation device
WO2016007356A1 (en) 2014-07-07 2016-01-14 Microdose Therapeutx, Inc. Inhalation device
WO2016014154A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder nebulizer
WO2016014586A1 (en) 2014-07-23 2016-01-28 Microdose Therapeutx, Inc. Dry powder medicament de-agglomerator
US10238821B2 (en) 2016-10-11 2019-03-26 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
US20200139057A1 (en) * 2017-06-27 2020-05-07 Korea United Pharm. Inc. Dry powder inhaler
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof

Also Published As

Publication number Publication date
CA999202A (en) 1976-11-02
ATA346473A (en) 1976-03-15
IT941426B (en) 1973-03-01
NL7305363A (en) 1974-05-07
CH563167A5 (en) 1975-06-30
ES208808U (en) 1976-04-01
FR2146202A1 (en) 1973-03-02
AT333415B (en) 1976-11-25
BE781102A (en) 1972-07-17
ES208808Y (en) 1976-07-16
FR2146202B1 (en) 1976-01-16
GB1331216A (en) 1973-09-26

Similar Documents

Publication Publication Date Title
US3807400A (en) Inhaling device for medicinal powder compositions
US5152284A (en) Disposable inhaler with pre-pierced capsule
CA2391466C (en) Inhaler device
US4069819A (en) Inhalation device
US4200099A (en) Apparatus for the inhalation of medicinal agents
DE60121144T2 (en) AN INHALATION DEVICE
DE60124531T2 (en) MEDICAMENT ADMINISTRATION SYSTEM WITH A MEDICAMENT CONTAINER WITH GAS FLOW IN AND OUT ON THE SAME PAGE
EP0388621A1 (en) Inhaler with regular complete emptying of the capsule
PL99318B1 (en) INHALATOR FOR ADMINISTRATION OF POWDERED SUBSTANCES
GB2165159A (en) Dosing device
DE69421415T2 (en) INHALATOR
GB654872A (en) Improvements in or relating to therapeutic medication
JPS6015337B2 (en) drug inhalation device
PH27041A (en) Powdered pharmaceutical inhaler
KR840000226A (en) Manufacturing method of new type of medicine
JP2954359B2 (en) Artemisia moxibustion device
JPS5934267A (en) Powdery drug applying apparatus
US3066669A (en) Nebulizer
US2569720A (en) Medicinal inhaler
US20090000619A1 (en) Powder Inhaler, System for Opening and Emptying Capsules
GB1396258A (en) Inhalation device
USD246321S (en) Disposable syringe for storing and administering pharmaceutical preparations
US2609817A (en) Inhaler
USD210179S (en) Container for dispensing eye drops
GB1072310A (en) Filter and retaining device