Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.

Patents

  1. Advanced Patent Search
Publication numberUS3798459 A
Publication typeGrant
Publication date19 Mar 1974
Filing date6 Oct 1972
Priority date6 Oct 1972
Also published asCA988321A1, DE2349927A1, DE2349927B2, DE2349927C3
Publication numberUS 3798459 A, US 3798459A, US-A-3798459, US3798459 A, US3798459A
InventorsAnderson N, Burtis C, Johnson W, Mailen J, Scott C
Original AssigneeAtomic Energy Commission
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Compact dynamic multistation photometer utilizing disposable cuvette rotor
US 3798459 A
Abstract
A compact analytical photometer of the rotary cuvette type designed to use small disposable cuvette rotors. A power driven cuvette rotor holder having a generally flat, circular configuration is provided with an integral, upstanding, annular lip for receiving, in an easily insertable and removable fashion, small disposable cuvette rotors. A series of axially extending apertures are disposed in a circular array through the rotor holder in axial alignment with respective cuvettes in the rotor to permit light to be transmitted through the cuvettes as the rotor holder and cuvette rotor rotate between a stationary light source and photodetector. Additional apertures extend through the rotor holder near its periphery to permit light passage through the rotor holder for rotor and cuvette synchronization purposes. Movable rotor and cuvette synchronization detectors are positioned along the periphery of the rotor holder for generating signals which are used to synchronize the photometer output with a computer and to provide rotor speed control. Rapid deceleration of the rotor holder and rotor for sample mixing purposes is accomplished by braking means engaging the rotor holder drive shaft.
Images(4)
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

United States Patent 1 Anderson et, al. v

[ 1 COMPACT DYNAMIC MULTISTATION PHOTOMETER UTILIZING DISPOSABLE CUVETTE ROTOR [75] Inventors: Norman G. Anderson, Oak Ridge;

Carl A. Burtis, Knoxville; Wayne F. Johnson, Loudon; James C. Mailen; Charles D. Scott, both of Oak Ridge, all of Tenn.

[73] Assignee: The United States of America as represented by the United States Atomic Energy Commission, Washington, DC.

22 Filed: Oct. 6,1972

[21] Appl. No.: 295,780

52 us. Cl. 250/218, 250/106 R 3.215.849 11/1965 Golden 250/218 Primary Examiner-Harold A. Dixon Attorney, Agent, or Firm-John A. I-Ioran 1 1 Mar. 19, 1974 57 ABSTRACT A compact analytical photometer of the rotary cuvette type designed to use small disposable cuvette rotors. A power driven cuvette rotor holder having a generally flat, circular configuration is provided with an integral, upstanding, annular lip for receiving, in an easily insertable and removable fashion. small disposable cuvette rotors. A series of axially extending apertures are disposed in a circular array through the rotor holder in axial alignment with respective cuvettes in the rotor to permit light to be transmitted through the cuvettes as the rotor holder and cuvette rotor rotate between a stationary light source and photodetector. Additional apertures extend through the rotor holder near its periphery to permit light passage through the rotor holder for rotor and cuvette synchronization purposes. Movable rotor and cuvette synchronization detectors are positioned along the periphery of the rotor holder for generating signals which are used to synchronize the photometer output with a computer and to provide rotor speed control. Rapid deceleration of the rotor holder and rotor for sample mixing purposes is accomplished by braking means engaging the rotor holder drive shaft.

9 Claims, 6 Drawing Figures PATENTEU MR 1 9 i974 SHEET 2 [IF 4 PATENTEDHAR 1 9 m4 3798.459

v sum u 0F 4 52 wxwmmw 51 wi 11 BACKGROUND OF THE INVENTION The invention described herein relates generally to photometers of the rotary cuvette type and more particularly to a compact photometer utilizing disposable cuvette rotors. It was made in the course of, or under, a contract with the U. S. Atomic Energy Commission.

A representative fast photometric analyzerof the rotary cuvette type is described in U. S. Pat. No. 3,555,284, issued to common assignee on Jan. 12, 1971. In the fast analyzer described in that patent, centrifugal force is used to transfer and mix samples and reagents in a mul ti-cuvette rotor. A stationary photometer scans the cuvettes during rotationsThe signals thus generated are evaluated by a computer, allowing the reactions taking placein'the respective cuvettes to be observed as they occur. Since all reactions are initiated simultaneously and are coupled with the continuous referencing of the spectrophotometric system of the analyzer, errors due to the electronic, mechanical, or chemical drift are minimized.

Although analyzers built in accordance with the aforementioned patent have been highly successful in that they operate with relatively low sample and reagent volume requirements, have demonstrated a high sample analysis rate, and are subject to automated operation, further improvement isdesirable. For example, the cuvette rotor described in that patent is a relatively large and complex structure of glass and polytetrafluorethylene rings sandwiched together and secured between a steel rotorbody and bolted flange ring. Such rotors are expensive and must be cleaned between analytical runs to avoid contamination of subsequent samples. correspondingly large cabinetry, drive motors, etc., must be used with the rotor with the result that the fast analyzer is not truly portable and requires a rela tively large amountof valuable laboratory space.

A further reduction in sample and reagent volume requirements is also desirable. Savings of expensive reagents would result from such a reduction in volume requirements. Also, the analyzer could be used in testing applications where it is difficult to obtain a sufficient volume of sample for analysis. For example, a greatly reduced sample volume requirement would facilitate operation in a pediatric laboratory where several analyses could be performed on the small volume of blood obtained from the finger or toe-prick of a newborn infant.

It is also desirable to make the cuvette rotors disposable to avoid the possibility of sample contamination and to permit preloading of standardized reagents. Such disposability would require the cuvette rotor to be simple and inexpensive to construct and easily inserted Other objects of the invention will be apparent upon examination of the following description of the invention and the appended drawings.

SUMMARY OF THE INVENTION In accordance with the invention, a compact analytical photometer of the rotary cuvette type is provided which is especially designed to use small disposable cuvette rotors. A power driven cuvette rotor holder having a generally flat, circular configuration is provided with an integral, upstanding, annular lip for receiving, in an easily insertable and removable fashion, small disposable cuvette rotors. A circular array of axially extending apertures extend through the rotor holder in axial alignment with respective cuvettes in the rotor to permit light to be transmitted axially through the cuvettes as the cuvette rotor and rotor holder rotate between a stationary light source and photodetector. Synchronization apertures extend through the rotor holder near its periphery to permit light passage through the holder and rotor for sample mixing purposes is accomplished by braking means engaging the rotor holder drive'shaft.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a top plan view, partially cut away, of a photometer made in accordance wtih the invention.

FIG. 2 is a vertical section view of the photometer of FIG. 1.

FIG. 3 is an enlarged plan view showing the static loading side of a disposable cuvette rotor for use in the photometer of FIGS. 1 and 2. l

FIG. 4 is an enlarged isometric view, sectioned and partially cut away, further illustrating the static loading side of the cuvette rotor of FIG. 3.

FIG. 5 is an enlarged plan view, showing the dynamic loading side of the cuvette rotor of FIGS. 3 and 4.

FIG. 6 is anenlarged isometric view, sectioned and DETAILED DESCRIPTION OF PREFERRED EMBODIMENT Referring now to the drawings, initially to FIGS. 1 and 2, a compact photometric analyzer is shown in a top plan view and in vertical section, respectively. Rotatably mounted on top of a small, generally rectangular, sheet metal cabinet I is a power-driven cuvette rotor holder 2 having a flat, plate-like, circular base 3 with an integral, upstanding, annular lip or rim 4 for receiving and retaining a disposable cuvette rotor 5. Two or more retaining pins 6 (only one shown) are fixed to rotor holder 2 within the confines of lip 4 and engage mating recesses in cuvette rotor 5. Pins 6 prevent relative rotation of the cuvette rotor and rotor holder during operation of the analyzer under conditions of high rotary acceleration, while permitting relatively effortless manual insertion or removal of the cuvette rotor under static conditions. A circular array of apertures 7 extends through base 3 of the rotorholder in axial register with respective sample analysis cuvettes 8 within cuvette rotor 5.

A movable photometric light source 9 provides a light beam of constant intensity interesecting rotor 5 at a point corresponding to the radial positions of sample analysis cuvettes 8. The light beam from source 9, indicated by a broken line in FIG. 2, is aligned in such a manner so as to be transmitted through each aperture 7 and cuvette 8 as they are rotated through the beam. Light source 9 includes a quartz-iodine incandescent lamp 10, a finned lamp housing 11, and a set of focusing lenses l2. Knob 14 is attached to housing 11 to facilitate positioning of the lamp housing during or immediately following analyzer operation when the housing is at an elevated temperature due to the heat generated by lamp 10.

An electronic photodetector 15 is disposed below rotor holder 2 and the top of cabinet 1 where it is positioned to receive light transmitted through sample analysis cuvettes 8 as they pass between the photodetector and light source 9. Photodetector 15 comprises a photomultiplier tube which provides an output signal proportional to the intensity of the light which it receives.

lnterposed between photodetector l5 and rotor holder 2 is a movable filter holder 16 which permits the selective positioning of one of a plurality of interference filters 17 in the path of the light transmitted through cuvettes 8. Filter holder 16 is fixed, by means of a set screw, to vertically extending shaft 18 which is rotatably supported by a roller thrust bearing 19 fixed within the base of fixture 20. Fixture 20, which is rigidly fixed to cabinet 1, is slotted to permit angular displacement of filter holder 16 within the limits necessary to align any of filters 17 above photodetector 15. A filter selector knob 22 is fixed to the top end of shaft 18 to enable an operator to manually select the filter desired.

As shown in FIG. 2, a thin-walled tube 23 serve as a mounting post for movable light source 9. Tube 23 is attached to and supported within fixture by means of a set screw and extends coaxially with shaft 18. R0- tatably engaging tube 23 immediately above fixture 20 is a first sleeve 24. A second sleeve 25, which serves as a mounting fixture for lamp housing 11, is fixed to first sleeve 24 by set screw means and is rotatable therewith. First sleeve 24 is provided with depressions 26 (only one shown) which are engaged by spring loaded detent 27 when the light source is in operating position as shown or swung away 90 for rotor replacement as indicated in phantom in FIG. 1. Radial adjustment of the light source to align it with the cuvettes is accomplished by loosening set screw 28 and sliding adjustment sleeve 29 within opening 30 in second sleeve 25. An indicator plate 32, which together with filter selector knob 22 shows the position of filter holder 16, is fixed to the top of tube 23 by set screw means. A spring loaded detent in knob 22 engages depressions in indicator plate 32 to provide positive positioning of the filter holder.

Fixed to the bottom of shaft 18 is an index wheel 33 engaging a micro switch 34. Rotation of shaft 13 during a filter selection operation causes a corresponding rotation of the index wheel and activation of the micro switch. This causes a different preset potentiometer to be connected into the photodetector high voltage supply circuit in order to maintain a constant signal from a reference cuvette filled with a water blank. A different preset potentiometer is used for each interference filter 17 in filter holder 16.

An alternative method for maintaininga constant output from the photodetector is described in copending application of common assignee Ser. No. 289,906 filed Sept. 18, 1972. According to that method, the signal level from the reference cuvette is compared with a preset desired level and adjustments to the high voltage photodetector supply made as needed by appropriate control circuitry to maintain the desired output. Drift in the photomultiplier tube and associated circuitry is also compensated for.

The rotor holder and cuvette rotor are rotatably driven by a combination servomotor-tachometer generator 35. A magnetic brake 36 acts on the rotor holder drive shaft 37 to provide rapid braking action to the cuvette rotor to enhance sample and reagent mixing in the cuvettes. Braking from a rotor speed of about 2,000 rpm to a standstill in less than 1 second has been achieved using magnetic brake 36.

Synchronization signals are provided by rotor and cuvette synchronization detectors 38 and 39, respectively. A similarly constructed detector 40 provides a signal for activating the automatic photomultiplier voltage control (not shown). Signals are generated when appropriately spaced apertures in the rotor holder pass through the detectors and allow light from a small tungsten incandescent lamp 41 disposed in the detector above the rotor holder to reach a photodiode 42 disposed in the detector below the cuvette holder. Detector 39, shown in section in FIG. 2, is representative of all three detectors. A circular track 44 for positioning the detectors partially encircles cuvette holder 2. Synchronization may be adjusted by moving the detectors along track 44 until proper synchronization is obtained and then securing them to the cabinet with locking screws.

As shown in FIG. 1, a circular array of synchronization apertures 45 is provided in rotor holder 2 to generate a signal in detector 39 just after each cuvette passes between light source 9 and photodetector 15. Single apertures 46 and 47 cause signals to be generated in detectors 38 and 40, respectively, on each revolution of the rotor holder.

The temperature of cuvette rotor 5 is monitored by means of a thermistor within retaining pin 6 which is positioned to extend between two cuvettes on a common radius with the circular array of cuvettes. The thermistor is further positioned within pin 6 so as to be axially centered within rotor 5. Such positioning provides a close correlation between the output of the thermistor and the temperature of the cuvettes. Slip rings 48 in electrical communication with the thermistor are provided on' the rotor holder for reading the signal from the thermistor. The rotor temperature and speed are both read from one meter 49 mounted on top of the analyzer cabinet.

Referring now to FIGS. 3 and 4, the static loading side of the disposable cuvette rotor 5 used in the analyzer of FIGS. 1 and 2 is illustrated in plan and sectioned isometric views, respectively. In construction, the rotor is of laminated design with a central, preferably opaque, plastic disk 51 sandwiched between outer transparent disks 52 and 53. A circular array of axially extending apertures are provided in disk 51 to serve as sample analysis cuvettes 8. Concentric annular arrays of sample and reagent loading cavities 54 and 55 are disposed on a one-to one basis along radii passing through each cuvette. As shown in FIG. 4, loading cavities 54 and 55 are formed from depressions incentral disk 51 and are closed by outer disk 52. Loading apertures 56 and 57 are provided in disk 52 in register with each cavity in the respective arrays of loading cavities. Static loading of reagents and samples through the loading apertures is possible using a hypodermic syringe or automated dispensing equipment. Radial liquid communication is provided by means of small connecting passageways 58 and 59 between respective sets of loading cavities and cuvettes. A central loading port 60 extends through disks 51 and 52 to permit dynamic loading of liquids using the dynamic loading side of the rotor described below in reference to FIGS. 5 and 6.

Plan and perspective views of the dynamic loading side of rotor 5 are shown in FIGS. 5 and 6, respectively.

Loading port 60 terminates in a distribution chamber provides a substantially equal distribution of liquid into 2 the respective passageways when rotor 5 is rotating and liquid is injected through port 60 into the distribution chamber.

Several methods of loading sample and reagent liquids in rotor 5 arepossible. One method involves static loading of individual samples and reagents in respective loading cavities 54 and 55. This is accomplished by inserting the sample and reagent volumes through respective loading apertures "56 and 57. Great flexibility is possible using this method since different combinations of samples and reagents are possible in each set of loading cavities. Rotation of the rotor following static loading effects transfer of the sample and reagent liquids into respective cuvettes for photometric analysis.

Another method of loading may be used where it is desired to either react a plurality of reagents with a single sample or a single reagent with a plurality of samples. ln that case, the single sample or reagent is injected through loading-port 60 into. the spinning. rotor and distributed equally to the cuvettes. The rotor is then brought to a standstill and individual sample or reagent loadings are made from the static loading side of the rotor.

Still another method of loading involves the preloading and lyophilization of different reagents in the respective cuvettes. When a photometric analysis is to be made, the lyophilized reagents are solubilized by injecting water or buffer into the spinning rotor in the manner described above. Sample fluid may be likewise dynamically loaded to obtain multiple chemical analyses on a single blood sample.

The above description of one embodiment of the invention should not be interpreted in a limiting sense. For example, the rotor may have a different number of sample analysis cuvettes than the 17 shown. Also, the particular arrangement of passageways for static and dynamic loading could be modified and/or omitted in part so that only static or dynamic loading would be possible. It is intended, rather, that the invention be limited only by the scope of the appended claims.

What is claimed is:

1. A compact fast analyzer of the rotory cuvette type comprising:

a. a power-driven cuvette rotor holder comprising a flat circular base, an annular, upstanding retaining rim integrally fixed to said base, and an axially extending upstanding pin fixed to said base within the radial confine of said rim; said base defining:

i. a first series of axially extending apertures disposed in a circular array through said base within the radialconfine of said rim.

ii. a second series of axially extending apertures disposed in a circular array through said base without the radial confine of said rim, said aper tures in said second series of apertures being equal in number to said apertures in said first series of apertures;

b. a removable cuvette rotor having a circular platelike configuration disposed on said base within the confine of said rim, said rotor having an opening for receiving said pin and, defining a circular array of sample analysis cuvettes in axial register with respective apertures in said first series of apertures;

c. a adjustable light source disposed above said cuvette rotor for providing a beam of light incident on said rotor assembly at a point corresponding to the radial position of said sample analysis cuvettes;

d. means for detecting light from said light source I after it has passed through 'said sample analysis cuvettes, said means for detecting light generating an output signal proportional to .the intensity of light detected; and

e. signal generating means disposed adjacent said rotor holder for detecting the passage of apertures in said second series of apertures.

2. The fast analyzer of claim 1 wherein an adjustable filterholder containing a plurality of absorbance filters extends between said base and said means for detecting light from said light source after it has passed through said sample analysis cuvettes.

3. The fast analyzer of claim 1 further including means for rapidly braking rotation of said rotor holder and rotor.

4. The fast analyzer of claim 1 further including a thermistor mounted within said upstanding pin for measuring the temper'ature'of said cuvette rotor, and electrical slip rings in electrical communication with said thermistor affixed to said rotor holder.

5. The fast analyzer of claim 4 wherein said upstanding pin is located at a radial position corresponding to the radius of said first series of axially extending apertures and said sample analysis cuvettes, and wherein said thermistor is within said pin so as to be axially centered within said removable cuvette rotor when said rotor is disposed on said base within the confine of said rim.

6. The fast analyzer of claim 1 wherein said removable cuvette rotor defines:

a. first and second sets of radially oriented loading cavities disposed in concentric annular arrays; and

b. means for effecting centrifugal passage of fluid from said first and second sets of loading cavities to respective cuvettes in said circular array of sample analysis cuvettes.

7. The fast analyzer of claim 6 wherein said cuvette rotor is of laminated construction with a central opaque disk sandwiched between first and second transparent disks, said sets of first and second cavities between said distribution chamber and respective cuvettes in said circular array of sample analysis cuvettes.

9. The fast analyzer of claim 8 wherein each of said distribution passageways intersects with adjacent distribution passageways at an acute angle so as to form a serrated periphery about said distribution chamber.

10K 1K 1' l

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US3215849 *5 Sep 19622 Nov 1965Golden Harry HSpectrophotometer with movable cuvette unit to isolate a single wavelength
US3555284 *18 Dec 196812 Jan 1971Anderson Norman GMultistation, single channel analytical photometer and method of use
US3576441 *17 Mar 197027 Apr 1971Hutton John TAnalytical photometer-to-digital computer interfacing system for real time data reduction
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US3873217 *24 Jul 197325 Mar 1975Atomic Energy CommissionSimplified rotor for fast analyzer of rotary cuvette type
US3890101 *15 Feb 197417 Jun 1975Us EnergyCollection ring for use in multiple-sample blood fractionation centrifugal rotors
US3953172 *10 May 197427 Apr 1976Union Carbide CorporationBlood, centrifuging
US4035156 *21 Jan 197712 Jul 1977The United States Of America As Represented By The United States Energy Research And Development AdministrationFilter type rotor for multistation photometer
US4226531 *29 Aug 19777 Oct 1980Instrumentation Laboratory Inc.Disposable multi-cuvette rotor
US4314970 *27 Aug 19809 Feb 1982Instrumentation Laboratory Inc.Rotor assemblies for use in photometric centrifugal analyzers
US4329061 *15 Jun 197911 May 1982National Research Development CorporationTurntable device for analyzing chemical substances
US4373812 *25 Mar 198115 Feb 1983Instrumentation Laboratory Inc.Cuvette assembly
US4446106 *15 Jan 19821 May 1984Instrumentation Laboratory Inc.Analysis system
US4509856 *16 Nov 19829 Apr 1985The United States Of America As Represented By The United States Department Of EnergyRotor for centrifugal fast analyzers
US4550084 *18 Nov 198329 Oct 1985Allied CorporationAnalysis system
US4580896 *7 Nov 19838 Apr 1986Allied CorporationMulticuvette centrifugal analyzer rotor with annular recessed optical window channel
US4580897 *31 May 19848 Apr 1986Allied CorporationCentrifugal analyzer rotors
US4580898 *31 May 19848 Apr 1986Allied CorporationAnalytical system
US4594533 *28 Nov 198410 Jun 1986National Research Development Corp.Device for analyzing chemical substance
US4680164 *18 Jul 198514 Jul 1987Fisher Scientific CompanyCentrifugal analyzer
US4740472 *5 Aug 198526 Apr 1988The United States Of America As Represented By The United States Department Of EnergyMethod and apparatus for automated processing and aliquoting of whole blood samples for analysis in a centrifugal fast analyzer
US4756883 *16 Sep 198612 Jul 1988E. I. Du Pont De Nemours And CompanyAnalysis device
US4762683 *16 Sep 19869 Aug 1988E. I. Du Pont De Nemours And CompanyAnalysis device
US4847205 *8 Apr 198711 Jul 1989Martin Marietta Energy Systems, Inc.Device and method for automated separation of a sample of whole blood into aliquots
US4900435 *31 Mar 198913 Feb 1990Large Scale BiolocyCentrifugal fast chromatograph
US4900446 *31 Mar 198913 Feb 1990Large Scale BiologyCentrifugal fast chromatograph
US4902479 *7 Nov 198320 Feb 1990Fisher Scientific CompanyCircumferential array of elongated radial extending cuvettes; prebention of mixing due to wicking
US5071625 *20 Jan 198810 Dec 1991Fisher Scientific CompanyRotor; circumferential array; interlock structure; aligned orientation; air circulation; centrifugal analyzers
US673440128 Jun 200111 May 20043M Innovative Properties CompanyEnhanced sample processing devices, systems and methods
US679167726 Aug 200214 Sep 2004Tosoh CorporationInformation measuring apparatus using a fine channel device
US69872536 May 200417 Jan 20063M Innovative Properties Companycomprises rotatable/heatable chambers; paramagnetism; for genetic amplification
US699276916 Nov 200131 Jan 2006Nagaoka & Co., Ltd.Apparatus and method for carrying out analysis of samples using semi-reflective beam radiation inspection
US702613115 Nov 200211 Apr 2006Nagaoka & Co., Ltd.Methods and apparatus for blood typing with optical bio-discs
US703374711 Apr 200225 Apr 2006Nagaoka & Co., LtdApparatus for use in the detection of preferential targets in sample
US708720319 Nov 20018 Aug 2006Nagaoka & Co., Ltd.Blood classification of humans; obtain erythrocytes, incubate with antibody, detect bound cells and classify
US709435419 Dec 200222 Aug 2006Bayer Healthcare LlcInstrument which utilizes centrifugal force to separate blood sample into erythrocytes and plasma; hemacrit measurement
US712571119 Dec 200224 Oct 2006Bayer Healthcare LlcInstrument which utilizes imposed centrifugal and capillary forces to monitor and determine presence/absence and amount of an analyte, such as glucose, albumin or bacteria in bodily or other fluids
US715704913 Nov 20022 Jan 2007Nagaoka & Co., Ltd.Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
US716410723 Nov 200516 Jan 20073M Innovative Properties CompanyEnhanced sample processing devices, systems and methods
US725121023 Jan 200331 Jul 2007Burstein Technologies, Inc.Method for triggering through disc grooves and related optical analysis discs and system
US73236605 Jul 200529 Jan 20083M Innovative Properties CompanyModular sample processing apparatus kits and modules
US73321299 Jan 200319 Feb 20083M Innovative Properties CompanySample processing device having process chambers with bypass slots
US734761719 Aug 200325 Mar 2008Siemens Healthcare Diagnostics Inc.Mixing in microfluidic devices
US742820020 Jul 200723 Sep 2008Burstein Technologies, Inc.Method for triggering through disc grooves and related optical analysis discs and system
US743538129 May 200314 Oct 2008Siemens Healthcare Diagnostics Inc.Shelf life; liquid mixture; control venting of moisture; polypropylene overcoated with metallized plastic films
US743593312 Jan 200714 Oct 20083M Innovative Properties CompanyEnhanced sample processing devices, systems and methods
US745912726 Feb 20022 Dec 2008Siemens Healthcare Diagnostics Inc.Method and apparatus for precise transfer and manipulation of fluids by centrifugal and/or capillary forces
US750737619 Dec 200224 Mar 20093M Innovative Properties CompanyApparatus for use in thermal analysis of mutiple liquids; PCR amplification, ligase chain reaction (LCR), self-sustaining sequence replication, enzyme kinetic studies, homogeneous ligand binding assays
US756918616 Mar 20054 Aug 20093M Innovative Properties CompanyBase plate comprising a thermal structure; releasably attached to the drive system for rotation; can be adapted to use with different test protocols
US75952002 Aug 200629 Sep 20093M Innovative Properties CompanySample processing devices and carriers
US76783346 Apr 200616 Mar 20103M Innovative Properties CompanySample processing devices
US77544745 Jul 200513 Jul 20103M Innovative Properties Companyinclude a rotating base plate on which the sample processing devices are located during operation, a cover and compression structure designed to force a sample processing device towards the base plate
US77632105 Jul 200527 Jul 20103M Innovative Properties CompanyCompliant microfluidic sample processing disks
US776793731 Oct 20073 Aug 20103M Innovative Properties CompanyModular sample processing kits and modules
US78550836 Apr 200621 Dec 20103M Innovative Properties CompanyThermal processing of multiple samples at the same time
US79320905 Aug 200426 Apr 20113M Innovative Properties CompanySample processing device positioning apparatus and methods
US793901824 Mar 200410 May 20113M Innovative Properties CompanyMulti-format sample processing devices and systems
US800305125 Jun 200923 Aug 20113M Innovative Properties CompanyThermal structure for sample processing systems
US80039265 Sep 200823 Aug 20113M Innovative Properties CompanyEnhanced sample processing devices, systems and methods
US80804094 Jun 201020 Dec 20113M Innovative Properties CompanySample processing device compression systems and methods
US809275923 Jun 201010 Jan 20123M Innovative Properties CompanyCompliant microfluidic sample processing device
US809747110 Nov 201017 Jan 20123M Innovative Properties CompanySample processing devices
US812889321 Dec 20076 Mar 20123M Innovative Properties CompanyThermal transfer methods and structures for microfluidic systems
US8277650 *12 Mar 20102 Oct 2012Terrasep, LlcMethods and apparatus for centrifugal liquid chromatography
US8277651 *12 Mar 20102 Oct 2012Terrasep, LlcMethods and apparatus for centrifugal liquid chromatography
US8293100 *12 Mar 201023 Oct 2012Terrasep, LlcMethods and apparatus for centrifugal liquid chromatography
US8293101 *12 Mar 201023 Oct 2012Terrasep, LlcMethods and apparatus for centrifugal liquid chromatography
US83377758 Sep 200825 Dec 2012Siemens Healthcare Diagnostics, Inc.Apparatus for precise transfer and manipulation of fluids by centrifugal and or capillary forces
US8343428 *24 Oct 20081 Jan 2013Rohm Co., Ltd.Microchip and method of using the same
US8367424 *14 Oct 20085 Feb 2013Rohm Co., Ltd.Microchip and method of using the same
US843546230 Dec 20057 May 20133M Innovative Properties CompanySample processing devices
US848190122 Aug 20119 Jul 20133M Innovative Properties CompanyEnhanced sample processing devices, systems and methods
US883479213 Nov 200916 Sep 20143M Innovative Properties CompanySystems for processing sample processing devices
US20090111675 *24 Oct 200830 Apr 2009Rohm Co., Ltd.Microchip and Method of Using the Same
US20100229635 *12 Mar 201016 Sep 2010Terrasep, LlcMethods and apparatus for centrifugal liquid chromatography
US20100230335 *12 Mar 201016 Sep 2010Terrasep, LlcMethods and apparatus for centrifugal liquid chromatography
US20100230353 *12 Mar 201016 Sep 2010Terrasep, LlcMethods and apparatus for centrifugal liquid chromatography
US20100230354 *12 Mar 201016 Sep 2010Terrasep, LlcMethods and apparatus for centrifugal liquid chromatography
US20100230355 *12 Mar 201016 Sep 2010Terrasep, LlcMethods and apparatus for centrifugal liquid chromatography
US20130115148 *21 Dec 20129 May 2013Rohm Co., Ltd.Microchip and Method of Using the Same
DE3425008A1 *6 Jul 19846 Feb 1986Boehringer Mannheim GmbhVerfahren und vorrichtung zur durchfuehrung analytischer bestimmungen
EP0184242A2 *12 Nov 198511 Jun 1986INSTRUMENTATION LABORATORY S.p.A.Method for measuring coagulation parameters
EP1288648A2 *27 Aug 20025 Mar 2003Tosoh CorporationInformation measuring apparatus having a fine channel device
EP1367399A2 *23 Apr 20033 Dec 2003Leisure, Inc.Biochemical analysis method, apparatus and cartridge
WO2005077541A1 *2 Feb 200525 Aug 2005Hach CoUser-configurable analytical rotor system
Classifications
U.S. Classification250/576, 250/303, 356/428
International ClassificationG01N21/03, G01N33/483, G01J1/02, G01N21/07
Cooperative ClassificationG01N21/07
European ClassificationG01N21/07