US3786985A - Blood collection container - Google Patents
Blood collection container Download PDFInfo
- Publication number
- US3786985A US3786985A US00321430A US3786985DA US3786985A US 3786985 A US3786985 A US 3786985A US 00321430 A US00321430 A US 00321430A US 3786985D A US3786985D A US 3786985DA US 3786985 A US3786985 A US 3786985A
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- US
- United States
- Prior art keywords
- container
- reduced portion
- blood
- closure means
- blood sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/15—Devices for taking samples of blood
- A61B5/150007—Details
- A61B5/150351—Caps, stoppers or lids for sealing or closing a blood collection vessel or container, e.g. a test-tube or syringe barrel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
Definitions
- the invention relates to an improved container for collecting, stabilizing and storing for long periods of time a blood specimen and methods therefor. More particularly, the present invention relates to a new and improved vacuum container for collecting and stabilizing blood which comprises a container member having one end which may be integrally closed and the other end closed by a plug, a reduced portion disposed between the longitudinal ends of said container member and a closure means disposed therein and adopted under the influence of centrifugal force to be securely received in the reduced portion.
- Vacuum-type containers for collecting blood specimens are well known in the art.
- such containers comprise a hollow tubular member provided with a hypodermic needle which is inserted directly or via a cannula into the container.
- the blood so-obtained, after appropriate treatment and separation, is tested for physiologically significant indications.
- the blood sample may be treated with an anticoagulant and centrifuged whereby the plasma is separated from the particulate matter, i.e. red and white cells and platelets and, thereafter, the plasma can be analyzed utilizing appropriate biochemical and serological tests.
- the blood sample may be allowed to clot without prior treatment and then centrifuged whereby the serum is separated from the particulate matter, and thereafter the serum can be analyzed utilizing biochemical and serological tests.
- the liquid portion of the blood that is, the plasma or serum
- prior art devices do function efficaciously to obtain blood samples, they require that the collected sample be promptly analyzed due to the fact that upon standing blood deteriorates, i.e. its constituents interact and thereby causes inaccurate analysis. Thus, prior art devices suffer from the defect of lacking means for preventing blood deterioration from occurring, that is, means which insure stabilization, if the blood sample is permitted to stand for extended periods of time.
- an evacuated tubular container made of suitable material
- a deformable member positioned in the container is moved under the influence of a higher centrifugal force to a position whereby it is securely received in said tapered position. In this position, the deformable member is positioned between the portions of the container which contains, respectively, the plasma or serum and the particulate matter. In this manner, the plasma or serum remain separated and contact with the particulate matter is avoided.
- the centrifugal force required to move the deformable member and to separate the plasma or the serum from the particulate matter is provided by any conventional centrifuge.
- Physicians, laboratory technicians and the like use centrifuges to spin or whirl containers or vessels containing blood sample to subject the sample to centrifugal force.
- Such devices usually consist of a rotor adopted to spin about a horizontal plane.
- the machine is equipped with a series of elongated recepticles pivotally mounted near the open ends so as to depend vertically when the rotor is at its rest position.
- the lower portions of the recepticles are adopted to swing outwardly and upwardly to bring the recepticles substantially radially upon rotation of the rotor.
- the recepticles of the centrifugal machine are loaded with the sample containing vessels by dropping the latter therein while the recepticles rest in depending positions.
- Such centrifugal devices can be activated so that the rotor can rotate at varying speeds. As should be evident, such machines are well known in the art.
- FIG. 1 is a side view with parts in cross section of an apparatus embodying the invention before use;
- FIG. 2 is a side view with parts in cross section of an apparatus embodying the invention showing transition of the closure means with respect to the reduced poron of h ssn riqa-.-
- FIG. 3 is a side view in cross section of an embodiment of the closure means of the apparatus of the inn i no a- FIG. 4 is a side view with parts in cross section of an apparatus embodying the invention after use; an d FIG. 5 is a side view with parts in cross section of another apparatus embodying the invention before use.
- a tubular member, vessel or container formed from any suitable material, preferably, glass or plastic, is provided with an open end 11 and a reduced intermediate section 17.
- a stopper 13 is removably received in the open end 1 1.
- the stopper 13 is made of rubber or any other suitable composition.
- the stopper 13 may be provided with a needle means not shown.
- the tubular member 10 is evacuated so that upon release of the vacuum, blood from a patient can be drawn into the tubular member in accordance with conventional techniques. Evacuation may be effected by passing an evacuating means through the stopper l3 and closure means 30 which evacuating means isconnccted to an evacuating mechanism.
- the tubular member, vessel or container 10 comprises two sections 20 and 21 and a reduced portion 17 which are integrally connected.
- Section 20 extends from end 11 which is closed by stopper 13 to the reduced portion 17.
- Section 20 includes a tapered portion 23.
- Section 21 extends from closed end 25 to the reduced portion 17 and includes tapered portion 24.
- the reduced portion 17 is positioned at the juncture of tapered portions 23 and 24.
- theopening defined by reduced portion 17 and by the inner walls of tapered portion 23 and 24 is of a diameter which is less than the diameter of the opening defined by the longitudinal walls of the vessel 10 which are not tapered.
- the longitudinal walls of section 20 are tapered so that the diameter of the opening defined by the upper end of section 20' opposite to closure member 30 is smaller than the diameter of the opening defined by the lower end of section 20' nearer to reduced portion 17, and the opening defined by reduced portion 17 and by the inner walls of tapered portions 23 and 24 are of a diameter which is less than the diameter of the opening defined by the upper end of section 20' opposite closure member 30.
- closure means 30 which may be of rubber, plastic or other suitable elastomeric deformable material.
- the closure means 30 comprises a tapered body portion 31 which centrally defines a diaphragm 32.
- the contiguous outer wall of said tapered body portion is adapted to engage the upper end of the inner surface of section 20 below stopper 13.
- the tapered body portion 31 of closure means 30 should be so sized that the upper portion thereof 34 will bear against the adjacent inner wall of vessel 10 and not move toward the reduced portion 17 under normal conditions or under the influence of a centrifugal force which will cause separation of the plasma or the serum from the particulate matter.
- a deformable tapered portion 33 Extending downwardly from diaphragm 32 is a deformable tapered portion 33. When in deformed condition, the configuration of tapered portion 33 conforms to the tapered portion 23 of section 20.
- container 10 should be constructed so that preferably the total volume contained within section 20 is approximately 40 percent of the total volume contained within the entire tube. Hence, the volume contained within section 21 is approximately 60 percent of the total volume contained in the entire tube.
- blood is collected in the evacuated container according to conventional procedures, by puncturing simultaneously the stopper 13 and the diaphragm 32 of closure means 30.
- the container is then placed on a centrifuge of conventional design.
- the serum or plasma is separated from the particulate matter with the serum or plasma being received in section 20 and particulate matter being received in section 21.
- the speed of the centrifuge is increased, preferably to about twice the speed employed to separate the plasma or the serum, however, speeds from about 2,500 RPM to about 4,000 RPM should be sufficient. As shown in FIG.
- the tapered end 33 of the closure means 30 is driven toward the reduced orifice 17 under the influence of the increased centrifugal force until it is wedged into tapered portion 23 as seen in FIG. 4.
- the plasma or the serum is permanently separated from the particulate and cross-reaction of one with the'other is precluded.
- the device in FIG. 2 is shown as being under the influence of an increased centrifugal speed. At this speed, the closure means 30 has begun its downward path toward the tapered portion 17. Under the influence of the increased centrifugal force, as depicted by the downwardly extending arrow in FIG. 2, the closure means 30 is deformed thereby permitting fluid to pass between its sides and the inner walls of section 20, as represented by the upwardly directioned arrows.
- the blood can be stored for long periods of time without degradation or biochemical changes occurring.
- the device or apparatus of the present invention provides a simple means for withdrawing, collecting, stabilizing, and transmitting blood samples without the necessity of utilizing separate devices. In this manner, the aseptic transfer of blood is accomplished in one apparatus without having to transfer the blood into separate devices or containers thereby subjecting the blood to additional sources of contamination by exposure to the atmosphere.
- a method for stabilizing a blood sample after collection in a hollow container which container comprises two closed ends connected by elongated sides, said sides having formed therein a reduced portion which extends inwardly into the interior of the hollow container, said container including a movable elastomeric closure means disposed in the interior of the hollow container between one of said closed ends in close proximity to the last-mentioned closed end and the reduced portion, such closure means having a deformable end extending toward the reduced portion, the other end of the closure means under normal conditions being in resilient engagement with the inner walls of said sides, which comprises (1) centrifuging said container at a speed that effects separation of the blood sample contained therein into two discrete phases, one phase consisting predominantly of the liquid constituent of the blood sample and the other consisting predominantly of the particulate phase; (2) increasing the centrifugal speed, to a speed which causes movement of the resilient member toward the reduced portion; and (3) centrifuging at such rate until the deformable end is securely received in the reduced portion.
Abstract
An improved blood collection container having a reduced portion disposed between its closed longitudinal ends and a stopper means disposed therein and adopted under the influence of centrifugal force to be securely received in the reduced portion is described.
Description
United States Patent [1 1 [111 3,786,985 Blaivas Jan. 22, 1974 [5 BLOOD COLLECTION CONTAINER 3,647,070 3/1972 Adler 210/83 3 7 k [75] Inventor: Murray Aaron Blaivas, New York, 5/19 1 PIC ermg 233/1 A X N.Y. FOREIGN PATENTS OR APPLICATIONS Assigneez Hoffman-La Roche Inc Nutley Great Britain Primary ExaminerGeorge H. Krizmanich [22] Flled 1973 Attorney, Agent, or Firm-Samuel L. Welt; Jon S. [21] Appl. No.: 321,430 Saxe; William G. Isgro [52] U.S. Cl. 233/26 57 ABSTRACT [51] Int. Cl B04b 9/12 [58] Field of Search 233/1 A, 1 R 210/83; An improved blood collection container having a re- 23/292 duced portion disposed between its closed longitudinal ends and a stopper means disposed therein and 56] References Cited adopted under the influence of centrifugal force to be UNTED STATES PATENTS securely received in the reduced portion is described.
3.508.653 4/1970 Coleman 210/83 1 Claim, 5 Drawing Figures BLOOD COLLECTION CONTAINER DETAILED DESCRIPTION OF THE INVENTION The invention relates to an improved container for collecting, stabilizing and storing for long periods of time a blood specimen and methods therefor. More particularly, the present invention relates to a new and improved vacuum container for collecting and stabilizing blood which comprises a container member having one end which may be integrally closed and the other end closed by a plug, a reduced portion disposed between the longitudinal ends of said container member and a closure means disposed therein and adopted under the influence of centrifugal force to be securely received in the reduced portion.
Vacuum-type containers for collecting blood specimens are well known in the art. In use, such containers comprise a hollow tubular member provided with a hypodermic needle which is inserted directly or via a cannula into the container. The blood so-obtained, after appropriate treatment and separation, is tested for physiologically significant indications. For example, the blood sample may be treated with an anticoagulant and centrifuged whereby the plasma is separated from the particulate matter, i.e. red and white cells and platelets and, thereafter, the plasma can be analyzed utilizing appropriate biochemical and serological tests. Alternatively, the blood sample may be allowed to clot without prior treatment and then centrifuged whereby the serum is separated from the particulate matter, and thereafter the serum can be analyzed utilizing biochemical and serological tests. In both instances, it is important that the liquid portion of the blood, that is, the plasma or serum, be physically separated from the particulate matter to insure stabilization of the plasma or the serum and, consequently, insure that the data obtained from the biochemical and serological tests accurately reflects the condition of the patient.
While prior art devices do function efficaciously to obtain blood samples, they require that the collected sample be promptly analyzed due to the fact that upon standing blood deteriorates, i.e. its constituents interact and thereby causes inaccurate analysis. Thus, prior art devices suffer from the defect of lacking means for preventing blood deterioration from occurring, that is, means which insure stabilization, if the blood sample is permitted to stand for extended periods of time.
As is known, a breakdown of the components of blood will occur if blood is permitted to stand for a period of time. The major cause of such deterioration can be attributed to the biochemical makeup of the blood sample and particularly the interaction between plasma or serum and the cellular portion of the blood, that is, the particulate matter found in blood. If biochemical changes occur in the sample, inaccurate analyses will result. Prompt separation of plasma or serum serum content of the specimen sample long after the blood sample has been collected.
Accurate diagnosis of a blood sample for physiological indications is indeed of critical importance in assuring proper medical care to the patient. In many circumstances, however, the patient is removed from the laboratory facilities which possess the capability of performing accurate multiple analysis of the sample. Thus, the transmittal of the sample to the laboratory for analysis thereof inherently presents problems.
It is an object of the present invention to provide the art with a blood collecting and stabilizing container and a method which assures the stabilization of blood even after the sample has been stored for long periods of time.
It is another object of the present invention to provide in a single apparatus means for collecting a blood sample and means for separating the liquid portion of blood from its particulate matter.
It is a further object of the present invention to furnish an apparatus which will include relatively few parts and which is capable of ready and economical manufacture.
It is a still further object of the present invention to provide a method performable on a conventional centrifugal machine.
In achieving the objects of the present invention, an evacuated tubular container made of suitable material,
preferably glass or plastic, is provided with a section which is tapered to provide a reduced tapered portion intermediate its end, preferably, no more than mid-way down the upper end of the tubular container. After blood is collected, the vessel is subject to varying centrifugal forces. Under the influence of a lower centrifugal force, the plasma or serum separates from the particulate matter. Thereafter, a deformable member positioned in the container is moved under the influence of a higher centrifugal force to a position whereby it is securely received in said tapered position. In this position, the deformable member is positioned between the portions of the container which contains, respectively, the plasma or serum and the particulate matter. In this manner, the plasma or serum remain separated and contact with the particulate matter is avoided.
The centrifugal force required to move the deformable member and to separate the plasma or the serum from the particulate matter is provided by any conventional centrifuge. Physicians, laboratory technicians and the like use centrifuges to spin or whirl containers or vessels containing blood sample to subject the sample to centrifugal force. Such devices usually consist of a rotor adopted to spin about a horizontal plane. The machine is equipped with a series of elongated recepticles pivotally mounted near the open ends so as to depend vertically when the rotor is at its rest position. The lower portions of the recepticles are adopted to swing outwardly and upwardly to bring the recepticles substantially radially upon rotation of the rotor. The recepticles of the centrifugal machine are loaded with the sample containing vessels by dropping the latter therein while the recepticles rest in depending positions. Such centrifugal devices can be activated so that the rotor can rotate at varying speeds. As should be evident, such machines are well known in the art.
For a full understanding of the nature and objects of the invention, reference should be had to the following detailed description taken in connection with the accompanying drawings in which:
FIG. 1 is a side view with parts in cross section of an apparatus embodying the invention before use;
FIG. 2 is a side view with parts in cross section of an apparatus embodying the invention showing transition of the closure means with respect to the reduced poron of h ssn riqa-.-
FIG. 3 is a side view in cross section of an embodiment of the closure means of the apparatus of the inn i no a- FIG. 4 is a side view with parts in cross section of an apparatus embodying the invention after use; an d FIG. 5 is a side view with parts in cross section of another apparatus embodying the invention before use.
Referring now to the drawings and particularly to FIG. 1, a tubular member, vessel or container formed from any suitable material, preferably, glass or plastic, is provided with an open end 11 and a reduced intermediate section 17. I u 7 A stopper 13 is removably received in the open end 1 1. The stopper 13 is made of rubber or any other suitable composition. The stopper 13 may be provided with a needle means not shown. The tubular member 10 is evacuated so that upon release of the vacuum, blood from a patient can be drawn into the tubular member in accordance with conventional techniques. Evacuation may be effected by passing an evacuating means through the stopper l3 and closure means 30 which evacuating means isconnccted to an evacuating mechanism.
The tubular member, vessel or container 10 comprises two sections 20 and 21 and a reduced portion 17 which are integrally connected. Section 20 extends from end 11 which is closed by stopper 13 to the reduced portion 17. Section 20 includes a tapered portion 23. Section 21 extends from closed end 25 to the reduced portion 17 and includes tapered portion 24. The reduced portion 17 is positioned at the juncture of tapered portions 23 and 24. As can be seen from FIG. 1, theopening defined by reduced portion 17 and by the inner walls of tapered portion 23 and 24 is of a diameter which is less than the diameter of the opening defined by the longitudinal walls of the vessel 10 which are not tapered.
In another embodiment of the invention, as shown in FIG. 5, in tubular member, vessel or container 10, the longitudinal walls of section 20 are tapered so that the diameter of the opening defined by the upper end of section 20' opposite to closure member 30 is smaller than the diameter of the opening defined by the lower end of section 20' nearer to reduced portion 17, and the opening defined by reduced portion 17 and by the inner walls of tapered portions 23 and 24 are of a diameter which is less than the diameter of the opening defined by the upper end of section 20' opposite closure member 30.
Referring still to F l6. 1 but now including FIG. 3 disposed within section 20 is closure means 30 which may be of rubber, plastic or other suitable elastomeric deformable material. The closure means 30 comprises a tapered body portion 31 which centrally defines a diaphragm 32. The contiguous outer wall of said tapered body portion is adapted to engage the upper end of the inner surface of section 20 below stopper 13. The tapered body portion 31 of closure means 30 should be so sized that the upper portion thereof 34 will bear against the adjacent inner wall of vessel 10 and not move toward the reduced portion 17 under normal conditions or under the influence of a centrifugal force which will cause separation of the plasma or the serum from the particulate matter.
Extending downwardly from diaphragm 32 is a deformable tapered portion 33. When in deformed condition, the configuration of tapered portion 33 conforms to the tapered portion 23 of section 20.
In accordance with this invention, container 10 should be constructed so that preferably the total volume contained within section 20 is approximately 40 percent of the total volume contained within the entire tube. Hence, the volume contained within section 21 is approximately 60 percent of the total volume contained in the entire tube.
In operation, blood is collected in the evacuated container according to conventional procedures, by puncturing simultaneously the stopper 13 and the diaphragm 32 of closure means 30. The container is then placed on a centrifuge of conventional design. Upon centrifuging at lower speeds, e.g., from about 1,500 RPM to 3,000 RPM, the serum or plasma is separated from the particulate matter with the serum or plasma being received in section 20 and particulate matter being received in section 21. After separation of the serum or the plasma from the particulate matter, the speed of the centrifuge is increased, preferably to about twice the speed employed to separate the plasma or the serum, however, speeds from about 2,500 RPM to about 4,000 RPM should be sufficient. As shown in FIG. 2, the tapered end 33 of the closure means 30 is driven toward the reduced orifice 17 under the influence of the increased centrifugal force until it is wedged into tapered portion 23 as seen in FIG. 4. Thus, the plasma or the serum is permanently separated from the particulate and cross-reaction of one with the'other is precluded.
The device in FIG. 2 is shown as being under the influence of an increased centrifugal speed. At this speed, the closure means 30 has begun its downward path toward the tapered portion 17. Under the influence of the increased centrifugal force, as depicted by the downwardly extending arrow in FIG. 2, the closure means 30 is deformed thereby permitting fluid to pass between its sides and the inner walls of section 20, as represented by the upwardly directioned arrows.
Thus, deterioration of the plasma or the serum caused by contact with blood cells or platelets after blood is removed from the human body is avoided. Also, the blood can be stored for long periods of time without degradation or biochemical changes occurring.
By proceeding in this simple manner utilizing readily available equipment, blood specimen samples can be withdrawn from the patient and the sample separated and stabilized into serum or plasma. After separation, the sample, can be transmitted to a laboratory where proper testing thereof can be undertaken. Blood specimen transmitted in this fashion yield accurate data for diagnostically significant parameters. Additionally, the device or apparatus of the present invention provides a simple means for withdrawing, collecting, stabilizing, and transmitting blood samples without the necessity of utilizing separate devices. In this manner, the aseptic transfer of blood is accomplished in one apparatus without having to transfer the blood into separate devices or containers thereby subjecting the blood to additional sources of contamination by exposure to the atmosphere.
Particularly noteworthy is also the fact that blood exposed to the atmosphere even for short periods of time will rapidly deteriorate. By utilizing the device which is the present invention, it is assured that the serum or the plasma are separated under aseptic conditions.
I claim:
1. A method for stabilizing a blood sample after collection in a hollow container, which container comprises two closed ends connected by elongated sides, said sides having formed therein a reduced portion which extends inwardly into the interior of the hollow container, said container including a movable elastomeric closure means disposed in the interior of the hollow container between one of said closed ends in close proximity to the last-mentioned closed end and the reduced portion, such closure means having a deformable end extending toward the reduced portion, the other end of the closure means under normal conditions being in resilient engagement with the inner walls of said sides, which comprises (1) centrifuging said container at a speed that effects separation of the blood sample contained therein into two discrete phases, one phase consisting predominantly of the liquid constituent of the blood sample and the other consisting predominantly of the particulate phase; (2) increasing the centrifugal speed, to a speed which causes movement of the resilient member toward the reduced portion; and (3) centrifuging at such rate until the deformable end is securely received in the reduced portion.
Claims (1)
1. A method for stabilizing a blood sample after collection in a hollow container, which container comprises two closed ends connected by elongated sides, said sides having formed therein a reduced portion which extends inwardly into the interior of the hollow container, said container including a movable elastomeric closure means disposed in the interior of the hollow container between one of said closed ends in close proximity to the lastmentioned closed end and the reduced portion, such closure means having a deformable end extending toward the reduced portion, the other end of the closure means under normal conditions being in resilient engagement with the inner walls of said sides, which comprises (1) centrifuging said container at a speed that effects separation of the blood sample contained therein into two discrete phases, one phase consisting predominantly of the liquid constituent of the blood sample and the other consisting predominantly of the particulate phase; (2) increasing the centrifugal speed, to a speed which causes movement of the resilient member toward the reduced portion; and (3) centrifuging aT such rate until the deformable end is securely received in the reduced portion.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US32143073A | 1973-01-05 | 1973-01-05 | |
US39257973A | 1973-08-29 | 1973-08-29 |
Publications (1)
Publication Number | Publication Date |
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US3786985A true US3786985A (en) | 1974-01-22 |
Family
ID=26982966
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US00321430A Expired - Lifetime US3786985A (en) | 1973-01-05 | 1973-01-05 | Blood collection container |
Country Status (8)
Country | Link |
---|---|
US (1) | US3786985A (en) |
JP (1) | JPS49103696A (en) |
DD (1) | DD110358A5 (en) |
DE (1) | DE2358493A1 (en) |
FR (1) | FR2213207A1 (en) |
IT (1) | IT1001920B (en) |
NL (1) | NL7316347A (en) |
SE (1) | SE7400120L (en) |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862042A (en) * | 1974-02-27 | 1975-01-21 | Becton Dickinson Co | Serum/plasma separator - piston with red-cell trapping surfaces |
US3879295A (en) * | 1973-08-17 | 1975-04-22 | Eastman Kodak Co | Vacutainer with positive separation barrier |
US3882021A (en) * | 1974-02-27 | 1975-05-06 | Becton Dickinson Co | Sealed assembly for separation of blood with anti-red cell barrier |
US3887464A (en) * | 1974-02-27 | 1975-06-03 | Becton Dickinson Co | Serum/plasma separator with centrifugal valve seal |
US3890237A (en) * | 1974-02-27 | 1975-06-17 | Becton Dickinson Co | Plasma separator {13 {0 cord stop type |
US3897343A (en) * | 1974-02-27 | 1975-07-29 | Becton Dickinson Co | Plasma separator-hydrostatic pressure type |
US3901219A (en) * | 1974-07-25 | 1975-08-26 | Becton Dickinson Co | Blood collecting container and method |
US3919085A (en) * | 1974-02-27 | 1975-11-11 | Becton Dickinson Co | Plasma separator assembly |
US3931010A (en) * | 1974-02-27 | 1976-01-06 | Becton, Dickinson And Company | Serum/plasma separators with centrifugal valves |
US3951801A (en) * | 1974-02-27 | 1976-04-20 | Becton, Dickinson And Company | Serum/plasma separator-strut stop type |
US4001122A (en) * | 1973-08-22 | 1977-01-04 | Telan Corporation | Method and device for separating blood components |
US4068798A (en) * | 1976-09-29 | 1978-01-17 | E. I. Du Pont De Nemours And Company | Method and apparatus for stopper removal |
USRE30276E (en) * | 1976-09-29 | 1980-05-20 | E. I. Du Pont De Nemours And Company | Apparatus for stopper removal |
EP0017127A2 (en) * | 1979-03-23 | 1980-10-15 | Terumo Corporation | A method for separating blood and a barrier device therefor |
US5560830A (en) * | 1994-12-13 | 1996-10-01 | Coleman; Charles M. | Separator float and tubular body for blood collection and separation and method of use thereof |
US5736033A (en) * | 1995-12-13 | 1998-04-07 | Coleman; Charles M. | Separator float for blood collection tubes with water swellable material |
US20020156439A1 (en) * | 1997-09-12 | 2002-10-24 | Michael J. Iskra | Collection container assembly |
US7074577B2 (en) | 2002-10-03 | 2006-07-11 | Battelle Memorial Institute | Buffy coat tube and float system and method |
US20100140182A1 (en) * | 2008-12-04 | 2010-06-10 | Chapman John R | Apparatus and method for separating and isolating components of a biological fluid |
US20100160135A1 (en) * | 2008-07-21 | 2010-06-24 | Becton, Dickinson And Company | Density Phase Separation Device |
US20100288694A1 (en) * | 2009-05-15 | 2010-11-18 | Becton, Dickinson And Company | Density Phase Separation Device |
US8394342B2 (en) | 2008-07-21 | 2013-03-12 | Becton, Dickinson And Company | Density phase separation device |
US20150231631A1 (en) * | 2012-11-30 | 2015-08-20 | Rarecyte, Inc. | Apparatus, system, and method for collecting a target material |
US9333445B2 (en) | 2008-07-21 | 2016-05-10 | Becton, Dickinson And Company | Density phase separation device |
US9682373B2 (en) | 1999-12-03 | 2017-06-20 | Becton, Dickinson And Company | Device for separating components of a fluid sample |
US9694359B2 (en) | 2014-11-13 | 2017-07-04 | Becton, Dickinson And Company | Mechanical separator for a biological fluid |
US11697114B2 (en) * | 2015-12-11 | 2023-07-11 | Babson Diagnostics, Inc. | Centrifugation method separating serum or plasma from whole blood using a specimen container having a cap to retain blood cells |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3932222A (en) * | 1974-12-20 | 1976-01-13 | J. K. & Susie L. Wadley Research Institute And Blood Bank | For isolating pathogenic microorganisms |
US4022576A (en) * | 1975-06-09 | 1977-05-10 | I. C. L. Scientific | Method and apparatus for preparation of liquids containing suspended material for examination |
US4361155A (en) * | 1980-10-29 | 1982-11-30 | Anastasio Frank W | Blood sampling unit |
US4830209A (en) * | 1988-05-09 | 1989-05-16 | Multi-Technology Inc. | Fail safe releasible locks for cappped disposable centrifuge containers |
US5533518A (en) * | 1994-04-22 | 1996-07-09 | Becton, Dickinson And Company | Blood collection assembly including mechanical phase separating insert |
EP0753741A4 (en) * | 1995-01-30 | 1998-04-29 | Niigata Engineering Co Ltd | Component separation member and component separator equipped with said member |
US6179787B1 (en) * | 1997-09-12 | 2001-01-30 | Becton Dickinson And Company | Collection container assembly |
Citations (3)
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US3508653A (en) * | 1967-11-17 | 1970-04-28 | Charles M Coleman | Method and apparatus for fluid handling and separation |
US3579303A (en) * | 1968-03-06 | 1971-05-18 | Donald E Pickering | System for handling specimens and other substances in medicine and physical sciences |
US3647070A (en) * | 1970-06-11 | 1972-03-07 | Technicon Corp | Method and apparatus for the provision of fluid interface barriers |
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1973
- 1973-01-05 US US00321430A patent/US3786985A/en not_active Expired - Lifetime
- 1973-11-22 IT IT31647/73A patent/IT1001920B/en active
- 1973-11-23 DE DE2358493A patent/DE2358493A1/en active Pending
- 1973-11-29 NL NL7316347A patent/NL7316347A/xx unknown
- 1973-12-21 JP JP49004690A patent/JPS49103696A/ja active Pending
-
1974
- 1974-01-03 DD DD175814A patent/DD110358A5/xx unknown
- 1974-01-03 FR FR7400115A patent/FR2213207A1/fr not_active Withdrawn
- 1974-01-04 SE SE7400120A patent/SE7400120L/sv unknown
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Cited By (65)
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US3879295A (en) * | 1973-08-17 | 1975-04-22 | Eastman Kodak Co | Vacutainer with positive separation barrier |
US4001122A (en) * | 1973-08-22 | 1977-01-04 | Telan Corporation | Method and device for separating blood components |
US3862042A (en) * | 1974-02-27 | 1975-01-21 | Becton Dickinson Co | Serum/plasma separator - piston with red-cell trapping surfaces |
US3882021A (en) * | 1974-02-27 | 1975-05-06 | Becton Dickinson Co | Sealed assembly for separation of blood with anti-red cell barrier |
US3887464A (en) * | 1974-02-27 | 1975-06-03 | Becton Dickinson Co | Serum/plasma separator with centrifugal valve seal |
US3890237A (en) * | 1974-02-27 | 1975-06-17 | Becton Dickinson Co | Plasma separator {13 {0 cord stop type |
US3897343A (en) * | 1974-02-27 | 1975-07-29 | Becton Dickinson Co | Plasma separator-hydrostatic pressure type |
US3919085A (en) * | 1974-02-27 | 1975-11-11 | Becton Dickinson Co | Plasma separator assembly |
US3931010A (en) * | 1974-02-27 | 1976-01-06 | Becton, Dickinson And Company | Serum/plasma separators with centrifugal valves |
US3951801A (en) * | 1974-02-27 | 1976-04-20 | Becton, Dickinson And Company | Serum/plasma separator-strut stop type |
US3901219A (en) * | 1974-07-25 | 1975-08-26 | Becton Dickinson Co | Blood collecting container and method |
USRE30276E (en) * | 1976-09-29 | 1980-05-20 | E. I. Du Pont De Nemours And Company | Apparatus for stopper removal |
US4068798A (en) * | 1976-09-29 | 1978-01-17 | E. I. Du Pont De Nemours And Company | Method and apparatus for stopper removal |
EP0017127A2 (en) * | 1979-03-23 | 1980-10-15 | Terumo Corporation | A method for separating blood and a barrier device therefor |
EP0017127A3 (en) * | 1979-03-23 | 1980-12-10 | Terumo Corporation | A method for separating blood and a barrier device therefor |
US5560830A (en) * | 1994-12-13 | 1996-10-01 | Coleman; Charles M. | Separator float and tubular body for blood collection and separation and method of use thereof |
US5736033A (en) * | 1995-12-13 | 1998-04-07 | Coleman; Charles M. | Separator float for blood collection tubes with water swellable material |
US20020156439A1 (en) * | 1997-09-12 | 2002-10-24 | Michael J. Iskra | Collection container assembly |
US9682373B2 (en) | 1999-12-03 | 2017-06-20 | Becton, Dickinson And Company | Device for separating components of a fluid sample |
US7074577B2 (en) | 2002-10-03 | 2006-07-11 | Battelle Memorial Institute | Buffy coat tube and float system and method |
US7329534B2 (en) | 2002-10-03 | 2008-02-12 | Battelle Memorial Institute | Buffy coat tube and float system and method |
US20080128340A1 (en) * | 2002-10-03 | 2008-06-05 | Thomas Haubert | Buffy coat tube and float system and method |
US20060154308A1 (en) * | 2002-10-03 | 2006-07-13 | Battelle Memorial Institute | Buffy coat tube and float system and method |
US20110171680A1 (en) * | 2002-10-03 | 2011-07-14 | Battelle Memorial Institute | Buffy coat tube and float system and method |
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US7915029B2 (en) | 2002-10-03 | 2011-03-29 | Battelle Memorial Institute | Buffy coat tube and float system and method |
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US8511479B2 (en) * | 2008-12-04 | 2013-08-20 | Thermogenesis Corp. | Apparatus and method for separating and isolating components of a biological fluid |
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US20100140182A1 (en) * | 2008-12-04 | 2010-06-10 | Chapman John R | Apparatus and method for separating and isolating components of a biological fluid |
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US20120193274A1 (en) * | 2008-12-04 | 2012-08-02 | Chapman John R | Apparatus and method for separating and isolating components of a biological fluid |
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US9375661B2 (en) | 2008-12-04 | 2016-06-28 | Cesca Therapeutics, Inc. | Apparatus and method for separating and isolating components of a biological fluid |
US9919308B2 (en) | 2009-05-15 | 2018-03-20 | Becton, Dickinson And Company | Density phase separation device |
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US9533303B2 (en) * | 2012-11-30 | 2017-01-03 | Rarecyte, Inc. | Apparatus, system, and method for collecting a target material |
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US9694359B2 (en) | 2014-11-13 | 2017-07-04 | Becton, Dickinson And Company | Mechanical separator for a biological fluid |
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Also Published As
Publication number | Publication date |
---|---|
JPS49103696A (en) | 1974-10-01 |
NL7316347A (en) | 1974-07-09 |
DD110358A5 (en) | 1974-12-12 |
SE7400120L (en) | 1974-07-08 |
IT1001920B (en) | 1976-04-30 |
DE2358493A1 (en) | 1974-07-25 |
FR2213207A1 (en) | 1974-08-02 |
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