|Publication number||US3708110 A|
|Publication date||2 Jan 1973|
|Filing date||6 Aug 1970|
|Priority date||11 Aug 1969|
|Also published as||DE2039898A1, DE2039898B2|
|Publication number||US 3708110 A, US 3708110A, US-A-3708110, US3708110 A, US3708110A|
|Inventors||H Unger, J Westberg, G Berndtsson, S Schwartz|
|Original Assignee||Aga Ab|
|Export Citation||BiBTeX, EndNote, RefMan|
|Referenced by (72), Classifications (16)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent Unger et al. [4 1 Jan. 2, 1973 541 4 CONTAINER FOR BLOOD 3,096,283 7/1963 Hein ..233 20  Inventors: Hans Peter Olaf Unger, Stockholm; i "5 3 R ru an ..l A X Eric wmbel'gi 3,239,l36 3/1966 Hem ..233
2 8 Bemdmn, 3,032,037 5/1962 Huber ..l28/276 Stockholm; Stephan Lars Schwartz, Lidingo, all of Sweden Assignee: AGA Aktiebolag, Lidingo, Sweden Filedz' Aug. 6, 1970 Appl' No.: 61,574
Foreign Application Priority Data Aug. ll, l969 Sweden ..l l 122/69 US. Cl ..233/26, 128/214 D, 128/272 Int. Cl. ..B04b 09/12 Field of Search ..l28/2l4 D, 214.2, 272, 276; 233/1 E, 20, 26, 27; l/2.l-2.4-
References Cited UNITED STATES PATENTS 9/1960 Chandler ..l28/276 Primary Examiner-Dalton L. Truluck Attorney-Larson, Taylor and Hinds [5 7] ABSTRACT A container for blood is provided in which blood received from a patient can be stored and processed without the necessity of being transferred to another container. For example, the blood can be centrifuged, frozen or transfused without the necessity of being transferred to another container. The container comprises a closed annular flexible container of a flexible material which is inert to blood and which is provided with at least one opening for the passage of blood into and out of the annular container. The flexible material may be enclosed in an inflexible material.
4 Claims, 4 Drawing Figures P'A TENTEDJM 2W5 3.708.110
SHEET 1 0F 2 IIIII/III INVENTORS HANS F? O. UNGER JOHAN E. H. WESTBERG GUNNAR I. :BERNDTSSON STEPHAN L. SCHWARTZ ATTORNEYS PATENTED'JAN 2W3 3.708 110 saw 2 OF 2 CONTAINER FOR BLOOD BACKGROUND OF THE INVENTION sterility should be maintained during the various processes which the blood has to undergo. It is desirable therefore that the same container should be used for different processes so as to avoid transfer of the blood.
It is an object of the present invention to provide a container which is suitable for all processes which are put into practice in todays blood-giving activities without the necessity of transferring the blood from one container to another. It is a further object of the invention to provide a method of storing blood which avoids the necessity of transferring blood from one container to another for processing the blood such as by freezing, centrifuging, and the like.
BRIEF SUMMARY OF THE INVENTION The foregoing and other objects which will be apparent to those having ordinary skill in the art are achieved according to the present invention by providing a container for blood which avoids the necessity of transferring the blood from one container to another for centrifuging, freezing, transfusion, and the like which comprises a closed annular container of a flexible material which is inert to blood and which is providedwith at least one opening for the passage of blood into and out of said container.
DETAILED DESCRIPTION There follows a detailed description of a preferred embodiment of the invention, together with accom panying drawings. However, it is to be understood that the detailed description and accompanying drawings are provided solely for the purpose of illustrating a preferred embodiment and that the invention is capable of numerous modifications and variations apparent to those skilled in the art without departing from the spirit and scope of the invention.
FIG. 1 is a schematic elevation view, in section, of a container according to the invention;
FIG. 2 is a schematic elevation view, in section, of an alternative container according to the invention;
FIG. 3 shows how the container according to FIG. 1 can be used in blood transfusion; and
FIG. 4 is a radial elevation section of a centrifuge according to co-pending application Ser. No. 61,583, filed Aug. 6, 1970 showing the use of several containers according to the present invention.
. The container shown in FIG. 1 is annular and has broadly speaking the shape of a disc, the disc being formed by an outer wall 1 and an inner wall 2 with an opening 3 in the center. The disc is conical in section. At the inner portion of the annular container, a tube 4 is connected which serves for the feed and discharge of In place of the single tube 4 shown, a plurality of such connecting tubes may be arranged, distributed in a suitable manner along the periphery of the inner wall 5 of the annular container.
The walls of the container are inert to blood and may be of laminar construction with an inside layer of a material that is harmless to blood, such as Teflon or polyethylene, and an outer layer of strong material with mechanical strength and freezing resistance, for example nylon.
The annular shape of the container shown in suitable and practical for centrifuging and for other treatment of the blood. The annular form represents a shape which can easily be adapted to a centrifuge, the central portion of which can pass through the opening in the center of the container. Moreover, owing to its flexibility, the container is suitable for application in transfusion, since it can readily be brought to the shape shown in FIG. 3 for delivery of the blood contained in it, leaving behind only a negligible residue.
In the modified embodiment according to FIG. 2 there is an inner flexible container 7 and an inflexible outer portion 8 enclosing the flexible container and consisting of a bottom portion 8 with a lid 8" placed therein. The inner portion 7 in its relaxed condition may have a shape as shown in FIG. 2 or the shape which is shown in FIG. 1. In the latter case the shape shown in FIG. 2 is obtained through deformation when the inner portion 7 is placed in the outer portion 8. The latter is of rigid material such as rigid plastic and of a suitable annular shape so as to enclose the inner portion 7 without forming a space between inner and outer portion. If the rigid material has good thermal conductivity, the container according to FIG. 2 is suitable for freezing of blood. The rigid outer portion can be given an appropriate volume corresponding to the quantity of blood usually occurring in transfusions.
FIG. 3 shows a container in accordance with FIG. 1 or an inner portion of a container according to FIG. 2 in position to be used in blood transfusion. Owing to its flexibility, container 9 can be inserted in a transfusion bucket 10, in the bottom of which is a hole I1 through which the tube 4 can be conducted for connection to the patient.
The container has particular utility in a centrifuge of the type described in US. application Serial No. 61,583 filed August 6, 1970 which is incorporated herein by reference.
Utilization of several containers in a centrifuge is illustrated in FIG. 4. The centrifuge comprises a rotating chamber 12 containing a compressible container 13 according to the invention for the liquid to be centrifuged. The centrifuge also includes means 14 to compress the container against conical member 19 to transfer liquid from the container during centrifugation. The compressing means is also capable of compressing one or more further compressible containers 15, I6, 17 according to the invention to transfer liquid therefrom to the first-mentioned compressible container 13. The compressing means is preferably a diaphragm member which is urged by centrifugal force against a compressible container. In one application, container I3 is filled with blood to be centrifuged and, after the serum is separated by rotation of chamber 12 about the axis of rotor 18 a valve is opened permitting the diaphragm to compress container 13 to transfer the serum to a further container 15. The valve is then closed and speed reduced until the diaphragm returns to its rest position causing compression of a still further container 17 provided with wash water. A valve is then opened to permit transfer of some or all of the wash water into the first-mentioned container 13 and the device may then be braked to cause the water to mix with the blood cells therein. The washed blood cells are then centrifuged and the water transferred to the water container 17 or yet a still further container 16 by the actuation of an appropriate valve similarly as in the case of transferring the serum. The washing operation is repeated if desired until all of the wash water has been utilized.
What is claimed is:
1. In combination, a centrifuge having a rotor and, disposed about said rotor in said centrifuge, an annular container for holding blood during rotation of said centrifuge, said annular container being made of a flexible material and comprising a hollow annular chamber formed by two annular side walls spaced apart a short,
distance and by two transverse end walls extending between and joining the edges of said annular sides thus forming said chamber, the central area of said container within the annular chamber being open such that the annular container is disposable about said rotor, and said annular container including a tube attached to the end wall of said container adjacent the open central area of the container for conveying blood into and out of said annular container.
2. The combination according to claim 1 wherein said container includes an outer portion of non-flexible material totally enclosing said flexible annular container.
3. The combination according to claim 1 wherein said outer wall is formed by the outer edges of said annular sides being bent towards one another and joined to each other.
4. An annular container for holding blood during centrifuging, said container being made of flexible material and comprising a hollow annular chamber formed by two annular side walls spaced apart a short distance and by two transverse end walls extending between and joining the edges of said annular sides thus forming said chamber, the central area of said container within the annular chamber being open such that the annular container is disposable about a centrifuge rotor, said annular container including a tube attached to the end wall of said container adjacent the open central area of the container for conveying blood into and out of said annular container, said chamber being conical such that the container is adapted to bear against a conical member in a centrifuge during centrifuging.
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3858796 *||14 Nov 1972||7 Jan 1975||Stephan L Schwartz||Container for use in treatment of liquid|
|US4007871 *||13 Nov 1975||15 Feb 1977||International Business Machines Corporation||Centrifuge fluid container|
|US4010894 *||21 Nov 1975||8 Mar 1977||International Business Machines Corporation||Centrifuge fluid container|
|US4112989 *||6 Nov 1975||12 Sep 1978||Baxter Travenol Laboratories, Inc.||Flexible collapsible blood freezing containers|
|US4278202 *||25 Jul 1979||14 Jul 1981||Separek Teknik Ab||Centrifuge rotor and collapsible separation container for use therewith|
|US4301963 *||15 Feb 1980||24 Nov 1981||Beckman Instruments, Inc.||Integral one piece centrifuge tube|
|US4464563 *||28 Aug 1981||7 Aug 1984||Jewett Warren R||Intravenous fluid warmer|
|US4804363 *||16 Jul 1986||14 Feb 1989||Autologous Blood Corporation||Apparatus and method for storing and processing blood|
|US4806252 *||30 Jan 1987||21 Feb 1989||Baxter International Inc.||Plasma collection set and method|
|US4834890 *||30 Jan 1987||30 May 1989||Baxter International Inc.||Centrifugation pheresis system|
|US4934995 *||12 Aug 1977||19 Jun 1990||Baxter International Inc.||Blood component centrifuge having collapsible inner liner|
|US4940543 *||30 Nov 1988||10 Jul 1990||Baxter International Inc.||Plasma collection set|
|US5006103 *||11 Jan 1990||9 Apr 1991||Baxter International Inc.||Disposable container for a centrifuge|
|US5076911 *||27 Mar 1991||31 Dec 1991||Baxter International Inc.||Centrifugation chamber having an interface detection surface|
|US5104526 *||26 May 1989||14 Apr 1992||Baxter International Inc.||Centrifugation system having an interface detection system|
|US5217426 *||14 Aug 1991||8 Jun 1993||Baxter International Inc.||Combination disposable plastic blood receiving container and blood component centrifuge|
|US5217427 *||4 Oct 1991||8 Jun 1993||Baxter International Inc.||Centrifuge assembly|
|US5322620 *||21 Aug 1991||21 Jun 1994||Baxter International Inc.||Centrifugation system having an interface detection surface|
|US5494578 *||22 Feb 1994||27 Feb 1996||Baxter International Inc.||Centrifugation pheresis system|
|US5571068 *||20 Jul 1994||5 Nov 1996||Baxter International Inc.||Centrifuge assembly|
|US5693232 *||29 Jan 1996||2 Dec 1997||Baxter International Inc.||Method for collecting a blood component concentration|
|US5704888 *||14 Apr 1995||6 Jan 1998||Cobe Laboratories, Inc.||Intermittent collection of mononuclear cells in a centrifuge apparatus|
|US5704889 *||14 Apr 1995||6 Jan 1998||Cobe Laboratories, Inc.||Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus|
|US5759147 *||7 Jun 1995||2 Jun 1998||Baxter International Inc.||Blood separation chamber|
|US5849203 *||3 Oct 1997||15 Dec 1998||Baxter International Inc.||Methods of accumulating separated blood components in a rotating chamber for collection|
|US5876321 *||9 Jun 1997||2 Mar 1999||Cobe Laboratories, Inc.||Control system for the spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus|
|US5879280 *||9 Jun 1997||9 Mar 1999||Cobe Laboratories, Inc.||Intermittent collection of mononuclear cells in a centrifuge apparatus|
|US6071423 *||29 Dec 1998||6 Jun 2000||Baxter International Inc.||Methods of collecting a blood plasma constituent|
|US6261217 *||14 Apr 1998||17 Jul 2001||Sanguistech Aktiebolag||Separation set having plate-like separation container with annular pinch valve for blood component preparation|
|US6656105||30 Nov 2001||2 Dec 2003||Gambro, Inc.||Centrifuge for processing blood and blood components in ring-type blood processing bags|
|US6689042||22 Jan 2002||10 Feb 2004||Gambro, Inc.||Centrifuge and container system for treatment of blood and blood components|
|US6740239||30 Nov 2001||25 May 2004||Gambro, Inc.||Method and apparatus for processing blood and blood components|
|US6780333||16 May 2000||24 Aug 2004||Baxter International Inc.||Centrifugation pheresis method|
|US6835171||16 Jan 2004||28 Dec 2004||Gambro Inc||Centrifuge and container system for treatment of blood and blood components|
|US7097774||24 Jul 2003||29 Aug 2006||Gambro Inc||Method for processing a blood product with a bag set having a multi-way connector|
|US7166217||25 Aug 2003||23 Jan 2007||Gambro Inc||Methods and apparatuses for blood component separation|
|US7235041||1 Aug 2006||26 Jun 2007||Gambro Bct, Inc.||Centrifuge for processing a blood product with a bag set having a processing bag|
|US7279107||16 Apr 2003||9 Oct 2007||Gambro, Inc.||Blood component processing system, apparatus, and method|
|US7347932||20 Feb 2004||25 Mar 2008||Gambro Bct, Inc.||Apparatus and method for separating a volume of composite liquid into at least two components|
|US7396451||15 Dec 2006||8 Jul 2008||Gambo Bci, Inc.||Methods and apparatus for blood component separation|
|US7413665||15 Dec 2006||19 Aug 2008||Gambro Bct, Inc.||Methods and apparatus for blood component separation|
|US7497944||27 Mar 2007||3 Mar 2009||Caridianbct, Inc.||Blood component processing system, apparatus, and method|
|US7648452||3 Jul 2008||19 Jan 2010||CardianBCT, Inc.||Apparatus for blood component separation|
|US7648639||14 Dec 2007||19 Jan 2010||CaridianBCT, Inc||Method for separating a volume of composite liquid into at least two components|
|US7708889||26 Jan 2009||4 May 2010||Caridianbct, Inc.||Blood component processing system method|
|US7819793||26 Oct 2010||Caridianbct, Inc.||Apparatus for separating a composite liquid into at least two components|
|US7833185||27 Apr 2007||16 Nov 2010||Caridianbct, Inc.||Apparatus for separating a volume of whole blood into at least three components|
|US7981019||14 Aug 2006||19 Jul 2011||Caridianbct, Inc.||Apparatus and method for separating a composite liquid into at least two components|
|US8057377||14 Aug 2006||15 Nov 2011||CaridianBCT, Inc||Apparatus and method for separating a composite liquid into at least two components|
|US8120760||30 Jun 2009||21 Feb 2012||Caridianbct, Inc.||Method and apparatus for separating a composite liquid into at least two components and for determining the yield of at least one component|
|US8173027||28 Aug 2007||8 May 2012||Terumo Bct, Inc.||Method of separating a composite liquid into at least two components|
|US8236184||31 Oct 2007||7 Aug 2012||Terumo Bct, Inc.||Method for separating a composite liquid into at least two components|
|US8277406||2 Oct 2012||Terumo Bct, Inc.||Method for separating a volume of whole blood into at least three components|
|US8287742||5 Dec 2007||16 Oct 2012||Terumo Bct, Inc.||Method for separating a composite liquid into at least two components|
|US9028388||6 May 2011||12 May 2015||Terumo Bct, Inc.||Multi-unit blood processor with volume prediction|
|US9079194||18 Jul 2011||14 Jul 2015||Terumo Bct, Inc.||Centrifuge for processing blood and blood components|
|US20030173274 *||3 Feb 2003||18 Sep 2003||Frank Corbin||Blood component separation device, system, and method including filtration|
|US20040104182 *||25 Aug 2003||3 Jun 2004||Gambro, Inc.||Methods and apparatuses for blood component separation|
|US20040147387 *||16 Jan 2004||29 Jul 2004||Gambro, Inc.||Centrifuge and container system for treatment of blood and blood components|
|US20050045567 *||20 Feb 2004||3 Mar 2005||Gambro, Inc.||Apparatus and method for separating a volume of composite liquid into at least two components|
|US20060270542 *||1 Aug 2006||30 Nov 2006||Gambro, Inc.||Centrifuge for Processing Blood and Blood Components|
|US20070084806 *||15 Dec 2006||19 Apr 2007||Gambro, Inc.||Methods and Apparatus for Blood Component Separation|
|US20070084807 *||15 Dec 2006||19 Apr 2007||Gambro, Inc.||Methods and Apparatus for Blood Component Separation|
|US20070118063 *||5 Oct 2006||24 May 2007||Gambro, Inc||Method and Apparatus for Leukoreduction of Red Blood Cells|
|US20080053203 *||28 Aug 2007||6 Mar 2008||Gambro Bct, Inc.||Apparatus and Method for Separating A Composite Liquid Into At Least Two Components|
|US20080093312 *||14 Dec 2007||24 Apr 2008||Gambro Bct, Inc.||Method for Separating A Volume of Composite Liquid Into At Least Two Components|
|US20080149564 *||5 Dec 2007||26 Jun 2008||Gambro Bct, Inc.||Apparatus and Method for Separating a Composite Liquid Into At Least Two Components|
|US20080283473 *||31 Oct 2007||20 Nov 2008||Gambro Bct, Inc.||Apparatus and Method for Separating a Composite Liquid Into At Least Two Components|
|US20080314822 *||3 Jul 2008||25 Dec 2008||Gambro Bct, Inc.||Apparatus for Blood Component Separation|
|US20090127206 *||26 Jan 2009||21 May 2009||Caridianbct, Inc.||Blood Component Processing System Method|
|USRE33924 *||14 Dec 1990||12 May 1992||Autologous Blood Corp.||Apparatus and method for storing and processing blood|
|WO1983000814A1 *||25 Aug 1982||17 Mar 1983||Warren Read Jewett||Electric intravenous fluid warmer, particularly for pediatric use|
|U.S. Classification||494/45, 494/43, 383/907, 604/408, 383/904, 422/44, 494/27|
|International Classification||A61M5/14, A61J1/00, A61J1/05|
|Cooperative Classification||A61J1/05, A61M5/14, Y10S383/904, Y10S383/907|
|European Classification||A61J1/05, A61M5/14|