US3696579A - Method of and device for preserving drugs for injection - Google Patents

Method of and device for preserving drugs for injection Download PDF

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US3696579A
US3696579A US152529A US3696579DA US3696579A US 3696579 A US3696579 A US 3696579A US 152529 A US152529 A US 152529A US 3696579D A US3696579D A US 3696579DA US 3696579 A US3696579 A US 3696579A
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Prior art keywords
casing
drug
injection
needle
needle assembly
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US152529A
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Shozo Narusawa
Noritoshi Iizuka
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YURIN TOKUSHI KOGYO CO Ltd
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YURIN TOKUSHI KOGYO CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/002—Packages specially adapted therefor, e.g. for syringes or needles, kits for diabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/06—Ampoules or carpules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3107—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle for needles
    • A61M2005/3109—Caps sealing the needle bore by use of, e.g. air-hardening adhesive, elastomer or epoxy resin

Definitions

  • ABSTRACT A drug preservation container unit for use in connection with injection. It comprises a vertically elongated casing sealed with a cap and a needle assembly held in an upright position within said casing, said needle assembly containing a freeze-drying-processed drug for use in injection and arranged to be connected to a syringe.
  • the unit contains such drug in such a small quantity as to be conveniently dispensed to a small number of persons.
  • the invention also provides a method of preserving drugs for use in injection in such a small quantity as mentioned above, comprising applying freeze-drying to the drug.
  • This invention relates to a method of and device for preserving drugs, and more particularly to a method of and device for preserving inoculums, such as BCG, PPD etc., or other drugs for injection, such as SLO, in such a small quantity as to be used for a small number of persons such, for example, as several persons.
  • inoculums for use in preventive inoculation are preserved in large containers, such as a large bottle, capable of containing such inoculums for a large number of persons, such, for example, as to 100 or more, for the purpose of making a collective inoculation.
  • the disadvantage is that lots of the inoculum contained in the container, for example, more than a half of it will adhere to the interior face of the container and will become useless.
  • the present invention is intended to eliminate such inconveniences and disadvantages indicated with conventional containers of this kind.
  • FIGS. 1 through 4 are longitudinal cross-sectional views, in an enlarged scale, of embodiments of the present invention, respectively.
  • the unit A comprises a relatively small vertically elongated cylindrical casing 1 with its upper end 1a opened which may be made of a glass, a metal or a synthetic resin, a support member 2 made of a flexible and soft rubber or synthetic resin, a needle assembly S composed of a needle 3 and a cup member 4 fixed to the base 30 of the needle and intercommucicating with the needle, and a cap 5 for closing the opening of the casing 1.
  • the support member 2 is provided with a base portion 2a adapted to be snugly inserted in the casing l and to be placed on the bottom wall 1b, and with a protrusion 2b protruding upwardly from the upper face of the base portion 2a and adapted to be pricked by the v sharpened tip 3b of needle 3.
  • the cap 5 has a flat portion 5a having the diameter corresponding substantially to the outside diameter of the cylindrical casing 1 and is provided with an inverted cup-shaped portion 5b depending from the flat portion 5a and arranged to be snugly inserted in the cup member 4 of needle assembly S.
  • the depth or height of the casing l is designed so that when the cap 5 is placed on the upper end la of casing 1 after the needle 3 of the needle assembly S has been stuck into the support 2 at its tip portion, the cupshaped portion 5b of the cap is brought into engagement with the upper portion of the inner peripheral face of cup member 4 of the needle assembly.
  • the inoculum or drug for injection is put into the cup member 4.
  • the inoculum or drug thus put into the cup member is prevented-from flowing off through the needle 3, because the opening of the tip 3b is sealingly closed by the portion, surrounding the tip portion, of the elastic support 2 which is in pressure contact with said tip portion.
  • the inoculum or drug in the cup member 4 is subjected to application of the process of freeze-drying which is often applied to, for example, foods for preservation.
  • the upper opening of casing 1 is sealed with the cap 5 airtight by interposing between the entire top face of casing 1 and the under-side of the cap 5 a packing material 7 and by applying a pressure to said cap to press the same against the top face of said casing.
  • the packing material which is suitable for use in the sealing is, for example, an atactic polypropylene, an atactic polyethylene, their mixed compounds, etc.
  • the casing 1 is sealed under a reduced atmospheric pressure.
  • the cap 5 When it is desired to use the container unit A for inoculation or injection, first, the cap 5 is removed and the needle assembly S is drawn out and attached to the glass cylinder of a conventional syringe, not shown, and then a necessary liquid for dissolving the contents is fed into the cup member 4 through the needle 3 by manipulating the plunger of the syringe in conventional manner. With this operation, the preserved contents is easily soluble and flows into the glass cylinder in a liquid state, thus enabling the injector to practice injection.
  • the drugs to be preserved in accordance with the present invention may either be of liquid or powder or of any other form as long as they are for use in injection and are suited for the application of the process of freeze-drying.
  • FIG. 2 there is shown a variant B of the drug preservation container unit A shown in FIG. 1.
  • the unit 8 is provided with a cuplike portion 2c having bore 2d and extending vertically upwardly from the protruding portion 2b of the support 2.
  • the depth of the bore 2d is made slightly shorter than the length of the needle 3 so that when the needle 3 is stuck at its tip into the protruding portion 2b, the cup member 4 of the needle assembly S is brought into contact at its bottom portion with the top surface of the cup-like portion 2c, thereby enabling the needle assembly S to be securely supported by the support member 2.
  • FIG. 2 is the same as the embodiment previously described in construction, with the exception of the provision of the cup-like portion 20.
  • the manner of assembling the unit and the method of preserving drugs in this instance are also the same as those in the first embodiment and further description as to these and other matters will be omitted.
  • the casing 1A is made of a metal, such as aluminum and is provided at its upper portion adjacent the upper end lAa with a contracted portion lAc defining the upper opening of the casing.
  • the support 2A inserted in the casing 1A is composed of an open-ended cylinder 2Ac of plastics, such as polyethylene, and a pad member 2Aa of flexible and soft rubber or plastics into which the tip portion of the needle 3 is stuck.
  • the support 2A is placed on the bottom lAb of casing 1A in an upright position, as shown.
  • the cup member 4A of the needle assembly S vertically supported by the support 2A within casing 1A is covered with a packing 8 of plastics, such as an urethane foam, inserted in the upper opening of casing 1A.
  • a packing 8 of plastics such as an urethane foam
  • the casing 1A is sealed with a flat cap 5A with the intermediary of the packing material 7 previously described.
  • the casing 1A is sealed under a reduced atmospheric pressure.
  • the casing 18 is made of a solid synthetic resin and is tapered inwardly upwardly at lBc and te 'n te in the 0 end lBa. Th e in IE is also fOIT fi d i nsl de theredi lith shoulder gor fi on lBd for receiving the lower portion of cup member 4B of the needle assembly S.
  • a support member 28 is inserted in the casing 1B and placed on the bottom 18b of casing 1B.
  • the cap 5B is provided with a cylindrical skirt 580 depending from the top portion 58a and having the same diameter as the casing 13, and also with an inverted cup-like portion SBb, and is arranged to be snugly mounted on the tapered portion of the casing 1B.
  • the casing 13 is sealed with the cap 58 under a normal atmospheric pressure.
  • the casing 18 covered with the cap 5B is packed with an aluminum foil 9, as shown in FIG. 4, to prevent moisture.
  • the casing 18 is preferably filled with nitrogen gas.
  • the drug for use in inoculation or injection is preserved in the cup member of the needle assembly and, for example, when several persons are inoculated with the preserved substance, the inoculation for at least the first person can be made by the needle without using other needle.
  • the tip of the needle is protected by the flexible support by being kept stuck into therein, so that the tip of the needle can be kept free from damage.
  • a method of preserving a drug for use in injection comprising the steps of: providing a support of flexible and soft rubber in a relatively small vertically elongated casing at the lower portion thereof; sticking the tip portion of a needle into said support, said needle having at its base a cup member arranged to be connected to the cylinder of a syringe; putting in said cup member the drug to be preserved, applying the process of freezedrying to said drug; and sealing said casing and said cup member of said needle assembly.

Abstract

A drug preservation container unit for use in connection with injection. It comprises a vertically elongated casing sealed with a cap and a needle assembly held in an upright position within said casing, said needle assembly containing a freeze-dryingprocessed drug for use in injection and arranged to be connected to a syringe. The unit contains such drug in such a small quantity as to be conveniently dispensed to a small number of persons. The invention also provides a method of preserving drugs for use in injection in such a small quantity as mentioned above, comprising applying freeze-drying to the drug.

Description

nited States Patent Narusawa et ai.
[54] METHOD OF AND DEVICE FOR PRESERVING DRUGS FOR INJECTION [72] Inventors: Shozo Narusawa; Noritoshi Iizuka,
both of Tokyo, Japan [73] Assignee: Yurin Tokushi Kogyo Co., Ltd.,
Tokyo, Japan- 221 Filed: 'June 14, 1971 21 Appl.No.: 152,529
Related U.S. Application Data [62] Division of Ser. No. 191, Jan. 2, 1970, Pat. No.
[30] Foreign Application Priority Data Jan. 9, 1969 Japan ..44/l840 [52] U.S. Cl. ..53/2l R [51] Int. Cl. ..B65b 55/00 [58] Field of Search ..53/21; 206/632 R; 128/272 51 Oct. 10, 1972 [56] References Cited UNITED STATES PATENTS 3,337,041 8/1967 Damaskus ..206/63.2 R 3,563,373 2/1971 Paulson ..206/63.2 R
Primary Examiner-Travis S. McGehee Attorney-McGlew and Toren [57] ABSTRACT A drug preservation container unit for use in connection with injection. It comprises a vertically elongated casing sealed with a cap and a needle assembly held in an upright position within said casing, said needle assembly containing a freeze-drying-processed drug for use in injection and arranged to be connected to a syringe. The unit contains such drug in such a small quantity as to be conveniently dispensed to a small number of persons. The invention also provides a method of preserving drugs for use in injection in such a small quantity as mentioned above, comprising applying freeze-drying to the drug.
1 Claim, 4 Drawing figures METHOD OF AND DEVICE FOR PRESERVING DRUGS FOR INJECTION This is a division of application Ser. No. 191, filed Jan. 2, 1970.
SUMMARY OF THE INVENTION This invention relates to a method of and device for preserving drugs, and more particularly to a method of and device for preserving inoculums, such as BCG, PPD etc., or other drugs for injection, such as SLO, in such a small quantity as to be used for a small number of persons such, for example, as several persons.
In general, inoculums for use in preventive inoculation are preserved in large containers, such as a large bottle, capable of containing such inoculums for a large number of persons, such, for example, as to 100 or more, for the purpose of making a collective inoculation.
However, when it is desired to inoculate only several persons or less, to open such container containing such a large amount of inoculum is disadvantageous from an economical point of view, since once the container is opened and part of the contents is used, the remainder is inevitably wasted.
On the other hand, in the case a small amount of inoculum is preserved in a small bottle or the like, the disadvantage is that lots of the inoculum contained in the container, for example, more than a half of it will adhere to the interior face of the container and will become useless.
v The present invention is intended to eliminate such inconveniences and disadvantages indicated with conventional containers of this kind.
It is, therefore, one object of the present invention to provide a device for preserving inoculums, injections or other drugs for use in injection in such a small quantity as to be suitable for use for a small number of persons such, for example, as several persons or less, so that when it is desired to inoculate or inject such a small number of persons, the injector can economically use the drug preserved in the container.
It is another object of the present invention to provide a drug container unit for use in connection with inoculation or injection, comprising a needle assembly and a drug for injection preserved in said needle assembly, and adapted to be used conveniently.
It is a further object of the present invention to provide a drug container unit of the type stated, which is small in size and light in weight so as to be freely portable.
It is a still further object of the present invention to provide a method of preserving drugs for use in injection in such a small quantity as to be conveniently dispensed to a small number of persons, such, for example, as several persons or less.
It is yet another object of the invention to provide a method for the purpose stated, which is capable of preserving drugs for a considerably long period of time.
These and other objects and advantages of the invention will become apparent upon reading the following detailed description of the invention in conjunction with the accompanying drawings in which:
FIGS. 1 through 4 are longitudinal cross-sectional views, in an enlarged scale, of embodiments of the present invention, respectively.
In the drawing like portions or parts are designated with like characters or numerals.
Referring to FIG. 1, there is shown a drug preservation container unit A for use in inoculation or injection. The unit A comprises a relatively small vertically elongated cylindrical casing 1 with its upper end 1a opened which may be made of a glass, a metal or a synthetic resin, a support member 2 made of a flexible and soft rubber or synthetic resin, a needle assembly S composed of a needle 3 and a cup member 4 fixed to the base 30 of the needle and intercommucicating with the needle, and a cap 5 for closing the opening of the casing 1.
The support member 2 is provided with a base portion 2a adapted to be snugly inserted in the casing l and to be placed on the bottom wall 1b, and with a protrusion 2b protruding upwardly from the upper face of the base portion 2a and adapted to be pricked by the v sharpened tip 3b of needle 3.
The cap 5 has a flat portion 5a having the diameter corresponding substantially to the outside diameter of the cylindrical casing 1 and is provided with an inverted cup-shaped portion 5b depending from the flat portion 5a and arranged to be snugly inserted in the cup member 4 of needle assembly S.
The depth or height of the casing l is designed so that when the cap 5 is placed on the upper end la of casing 1 after the needle 3 of the needle assembly S has been stuck into the support 2 at its tip portion, the cupshaped portion 5b of the cap is brought into engagement with the upper portion of the inner peripheral face of cup member 4 of the needle assembly.
Before sealing the upper opening of casing 1, and after the needle assembly S has been vertically held within the casing 1 by pricking the tip 3b of needle 3 into the support member 2, a predetermined amount of inoculum 6 or drug for injection is put into the cup member 4. In this case, the inoculum or drug thus put into the cup member is prevented-from flowing off through the needle 3, because the opening of the tip 3b is sealingly closed by the portion, surrounding the tip portion, of the elastic support 2 which is in pressure contact with said tip portion. Then, the inoculum or drug in the cup member 4 is subjected to application of the process of freeze-drying which is often applied to, for example, foods for preservation.
Upon application of the process of freeze-drying to the drug, the upper opening of casing 1 is sealed with the cap 5 airtight by interposing between the entire top face of casing 1 and the under-side of the cap 5 a packing material 7 and by applying a pressure to said cap to press the same against the top face of said casing. The packing material which is suitable for use in the sealing is, for example, an atactic polypropylene, an atactic polyethylene, their mixed compounds, etc. In the illustrated embodiment, the casing 1 is sealed under a reduced atmospheric pressure.
When it is desired to use the container unit A for inoculation or injection, first, the cap 5 is removed and the needle assembly S is drawn out and attached to the glass cylinder of a conventional syringe, not shown, and then a necessary liquid for dissolving the contents is fed into the cup member 4 through the needle 3 by manipulating the plunger of the syringe in conventional manner. With this operation, the preserved contents is easily soluble and flows into the glass cylinder in a liquid state, thus enabling the injector to practice injection.
The drugs to be preserved in accordance with the present invention may either be of liquid or powder or of any other form as long as they are for use in injection and are suited for the application of the process of freeze-drying.
Referring now to FIG. 2, there is shown a variant B of the drug preservation container unit A shown in FIG. 1. As shown in FIG. 2, the unit 8 is provided with a cuplike portion 2c having bore 2d and extending vertically upwardly from the protruding portion 2b of the support 2. The depth of the bore 2d is made slightly shorter than the length of the needle 3 so that when the needle 3 is stuck at its tip into the protruding portion 2b, the cup member 4 of the needle assembly S is brought into contact at its bottom portion with the top surface of the cup-like portion 2c, thereby enabling the needle assembly S to be securely supported by the support member 2.
Thus, the embodiment illustrated in FIG. 2 is the same as the embodiment previously described in construction, with the exception of the provision of the cup-like portion 20. The manner of assembling the unit and the method of preserving drugs in this instance are also the same as those in the first embodiment and further description as to these and other matters will be omitted.
Referring now to FIG. 3, there is shown another drug preservation container unit C according to the present invention. In the illustrated embodiment, the casing 1A is made of a metal, such as aluminum and is provided at its upper portion adjacent the upper end lAa with a contracted portion lAc defining the upper opening of the casing. The support 2A inserted in the casing 1A is composed of an open-ended cylinder 2Ac of plastics, such as polyethylene, and a pad member 2Aa of flexible and soft rubber or plastics into which the tip portion of the needle 3 is stuck. The support 2A is placed on the bottom lAb of casing 1A in an upright position, as shown.
The cup member 4A of the needle assembly S vertically supported by the support 2A within casing 1A is covered with a packing 8 of plastics, such as an urethane foam, inserted in the upper opening of casing 1A. After the packing 8 has been inserted in the opening, the casing 1A is sealed with a flat cap 5A with the intermediary of the packing material 7 previously described. In the illustrated embodiment, the casing 1A is sealed under a reduced atmospheric pressure.
After the opening of casing 1A has been sealed with cap 5A, the head portion of casing 1A with cap 5A is covered with an aluminum foil 5A for the purpose of protection of the cap 5A.
The manner of assemblingthe unit C and the method of preserving drugs in this instance are almost the same as those in the second embodiment B and further description as to these and other matters will not be made.
Referring now to FIG. 4, there is depicted another drug preservation container unit D according to the invention. In this embodiment, the casing 18 is made of a solid synthetic resin and is tapered inwardly upwardly at lBc and te 'n te in the 0 end lBa. Th e in IE is also fOIT fi d i nsl de theredi lith shoulder gor fi on lBd for receiving the lower portion of cup member 4B of the needle assembly S. A support member 28 is inserted in the casing 1B and placed on the bottom 18b of casing 1B.
The cap 5B is provided with a cylindrical skirt 580 depending from the top portion 58a and having the same diameter as the casing 13, and also with an inverted cup-like portion SBb, and is arranged to be snugly mounted on the tapered portion of the casing 1B. In this embodiment, the casing 13 is sealed with the cap 58 under a normal atmospheric pressure. The casing 18 covered with the cap 5B is packed with an aluminum foil 9, as shown in FIG. 4, to prevent moisture. In this instance, the casing 18 is preferably filled with nitrogen gas. The manner of assembling the unit and the method of preserving drugs in this instance are almost the same as those of the foregoing embodiments and, to avoid repetition further explanation as to these and other matters will be omitted.
As may be seen from the foregoing, in accordance with the present invention, the drug for use in inoculation or injection is preserved in the cup member of the needle assembly and, for example, when several persons are inoculated with the preserved substance, the inoculation for at least the first person can be made by the needle without using other needle. Further, in accordance with the invention, the tip of the needle is protected by the flexible support by being kept stuck into therein, so that the tip of the needle can be kept free from damage.
What we claim is:
l. A method of preserving a drug for use in injection, comprising the steps of: providing a support of flexible and soft rubber in a relatively small vertically elongated casing at the lower portion thereof; sticking the tip portion of a needle into said support, said needle having at its base a cup member arranged to be connected to the cylinder of a syringe; putting in said cup member the drug to be preserved, applying the process of freezedrying to said drug; and sealing said casing and said cup member of said needle assembly.

Claims (1)

1. A method of preserving a drug for use in injection, comprising the steps of: providing a support of flexible and soft rubber in a relatively small vertically elongated casing at the lower portion thereof; sticking the tip portion of a needle into said support, said needle having at its base a cup member arranged to be connected to the cylinder of a syringe; putting in said cup member the drug to be preserved, applying the process of freeze-drying to said drug; and sealing said casing and said cup member of said needle assembly.
US152529A 1969-01-09 1971-06-14 Method of and device for preserving drugs for injection Expired - Lifetime US3696579A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP44001840A JPS5011713B1 (en) 1969-01-09 1969-01-09

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US191A Expired - Lifetime US3637072A (en) 1969-01-09 1970-01-02 Device for preserving drugs for injection
US152529A Expired - Lifetime US3696579A (en) 1969-01-09 1971-06-14 Method of and device for preserving drugs for injection

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JP (1) JPS5011713B1 (en)
CH (1) CH521129A (en)
DE (1) DE2000772C3 (en)
DK (1) DK121462B (en)
FR (1) FR2027995A1 (en)
GB (1) GB1261779A (en)

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US4716710A (en) * 1985-07-01 1988-01-05 Institut-Merieux Process for the preparation in a series of self-injectable syringes in a sealed container, for lyophilized medications, and device for the implementation of said process
FR2791254A1 (en) * 1999-03-25 2000-09-29 Pierre Frezza AMPOULE FOR THE PACKAGING OF A LIQUID FOR MEDICAL USE
US6434913B1 (en) * 2000-09-15 2002-08-20 Thomas Hatch Single-use syringe
US20110094189A1 (en) * 2008-06-19 2011-04-28 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Method for filling dual-chamber systems in pre-sterilizable carrier systems and pre-sterilizable carrier system
US20140103045A1 (en) * 2008-06-19 2014-04-17 Arzneimittel Gmbh Apotheker Vetter & Co.Ravensburg Method for filling dual-chamber systems in pre-sterilizable carrier systems and pre-sterilizable carrier system
US20170341784A1 (en) * 2014-10-15 2017-11-30 Hoffmann-La Roche Inc. Method for providing in a primary packaging container a dried solid product containing an active pharmaceutical ingredient
US9919108B2 (en) 2011-08-30 2018-03-20 Novo Nordisk A/S Arrangement for sequential delivery of fluid volumes

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US4716710A (en) * 1985-07-01 1988-01-05 Institut-Merieux Process for the preparation in a series of self-injectable syringes in a sealed container, for lyophilized medications, and device for the implementation of said process
FR2791254A1 (en) * 1999-03-25 2000-09-29 Pierre Frezza AMPOULE FOR THE PACKAGING OF A LIQUID FOR MEDICAL USE
WO2000057834A1 (en) * 1999-03-25 2000-10-05 Pierre Frezza Ampoule containing a liquid for medical purposes
US6398031B1 (en) 1999-03-25 2002-06-04 Pierre Frezza Vial for packaging a liquid for medical use
US6434913B1 (en) * 2000-09-15 2002-08-20 Thomas Hatch Single-use syringe
US20110094189A1 (en) * 2008-06-19 2011-04-28 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Method for filling dual-chamber systems in pre-sterilizable carrier systems and pre-sterilizable carrier system
US20140103045A1 (en) * 2008-06-19 2014-04-17 Arzneimittel Gmbh Apotheker Vetter & Co.Ravensburg Method for filling dual-chamber systems in pre-sterilizable carrier systems and pre-sterilizable carrier system
US8763350B2 (en) * 2008-06-19 2014-07-01 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Method for filling dual-chamber systems in pre-sterilizable carrier systems
US11027882B2 (en) 2008-06-19 2021-06-08 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Pre-sterilizable carrier system
US9919108B2 (en) 2011-08-30 2018-03-20 Novo Nordisk A/S Arrangement for sequential delivery of fluid volumes
US20170341784A1 (en) * 2014-10-15 2017-11-30 Hoffmann-La Roche Inc. Method for providing in a primary packaging container a dried solid product containing an active pharmaceutical ingredient
US10696431B2 (en) * 2014-10-15 2020-06-30 Hoffmann-La Roche Inc. Method for providing in a primary packaging container a dried solid product containing an active pharmaceutical ingredient

Also Published As

Publication number Publication date
CH521129A (en) 1972-04-15
DE2000772B2 (en) 1981-06-19
JPS5011713B1 (en) 1975-05-06
GB1261779A (en) 1972-01-26
US3637072A (en) 1972-01-25
FR2027995A1 (en) 1970-10-02
DE2000772C3 (en) 1982-02-11
DE2000772A1 (en) 1970-09-03
DK121462B (en) 1971-10-18

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