US3687135A - Magnesium-base alloy for use in bone surgery - Google Patents
Magnesium-base alloy for use in bone surgery Download PDFInfo
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- US3687135A US3687135A US858149A US3687135DA US3687135A US 3687135 A US3687135 A US 3687135A US 858149 A US858149 A US 858149A US 3687135D A US3687135D A US 3687135DA US 3687135 A US3687135 A US 3687135A
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- magnesium
- alloy
- bone
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- manganese
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- Expired - Lifetime
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- 229910045601 alloy Inorganic materials 0.000 title abstract description 45
- 239000000956 alloy Substances 0.000 title abstract description 45
- 210000000988 bone and bone Anatomy 0.000 title abstract description 25
- 238000001356 surgical procedure Methods 0.000 title abstract description 8
- 239000000203 mixture Substances 0.000 claims description 13
- 229910052779 Neodymium Inorganic materials 0.000 claims description 8
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 claims description 8
- 229910052727 yttrium Inorganic materials 0.000 claims description 4
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 claims description 4
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract description 23
- 229910052749 magnesium Inorganic materials 0.000 abstract description 23
- 239000011777 magnesium Substances 0.000 abstract description 23
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 abstract description 13
- 229910052748 manganese Inorganic materials 0.000 abstract description 13
- 239000011572 manganese Substances 0.000 abstract description 13
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 11
- 229910052793 cadmium Inorganic materials 0.000 abstract description 11
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 abstract description 11
- 229910052791 calcium Inorganic materials 0.000 abstract description 11
- 239000011575 calcium Substances 0.000 abstract description 11
- 229910052782 aluminium Inorganic materials 0.000 abstract description 10
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract description 10
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 abstract description 6
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract description 6
- 229910052761 rare earth metal Inorganic materials 0.000 abstract description 6
- 229910052710 silicon Inorganic materials 0.000 abstract description 6
- 239000010703 silicon Substances 0.000 abstract description 6
- 229910052709 silver Inorganic materials 0.000 abstract description 6
- 239000004332 silver Substances 0.000 abstract description 6
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 abstract description 5
- 229910052726 zirconium Inorganic materials 0.000 abstract description 5
- 238000010521 absorption reaction Methods 0.000 description 8
- 239000007789 gas Substances 0.000 description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 6
- 239000001257 hydrogen Substances 0.000 description 6
- 229910052739 hydrogen Inorganic materials 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229910000861 Mg alloy Inorganic materials 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 150000002910 rare earth metals Chemical class 0.000 description 3
- 208000010392 Bone Fractures Diseases 0.000 description 2
- 206010017076 Fracture Diseases 0.000 description 2
- 206010020649 Hyperkeratosis Diseases 0.000 description 2
- -1 Neodymium Cadmium Calcium Chemical compound 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
- 229910052790 beryllium Inorganic materials 0.000 description 2
- ATBAMAFKBVZNFJ-UHFFFAOYSA-N beryllium atom Chemical compound [Be] ATBAMAFKBVZNFJ-UHFFFAOYSA-N 0.000 description 2
- 238000007596 consolidation process Methods 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229910052725 zinc Inorganic materials 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 238000007731 hot pressing Methods 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000009940 knitting Methods 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 235000014380 magnesium carbonate Nutrition 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C24/00—Alloys based on an alkali or an alkaline earth metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
- C22C23/06—Alloys based on magnesium with a rare earth metal as the next major constituent
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C25/00—Alloys based on beryllium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
- A61F2310/00005—The prosthesis being constructed from a particular material
- A61F2310/00011—Metals or alloys
- A61F2310/00035—Other metals or alloys
- A61F2310/00041—Magnesium or Mg-based alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Definitions
- ABSTRACT A magnesium-base alloy for use in bone surgery which contains the following components, wt.%:
- Rare earth element 0.4-4.0 Cadmium 005-1 .2 An element from the group consisting of calcium and aluminum 0.05-1 .0 Manganese 0.05-.05 Silver 0-0.8 Zirconium 0-0.8 Silicon 0-0.3 Magnesium remainder 5 Claims, N0 Drawings MAGNES-BASE ALLOY FOR USE IN BONE SURGERY
- the present invention relates to magnesium-base alloys employed as a joining and fixation material in bone surgery.
- Magnesium was first employed for osteosynthesis by Lambotte in 1907. In fracture of the bones of the lower leg a magnesium plate secured with gold-plate steel nails was used, but in 8 days the plate disintegrated with the formation of a large amount of gas under the skin. In spite of Lambottes failure, study of the effect of magnesium on the surrounding tissue and the body as a whole continued.
- the rate of absorption of the alloy compared to the rate of consolidation of the bone shall be such that at the moment of complete restoration of the bones entirety the alloy shall retain sufficient strength, i.e., the process of absorption shall be completed 1.5-2 months after knitting of the bone;
- the rate of evolution of hydrogen during absorption of the alloy in the body shall be less or equal to the rate of absorption of hydrogen by the body.
- the alloy shall contain elements which stimulate the growth of bone tissue, such as calcium and cadmium;
- the alloy shall not contain elements which are harmful for the living organism, such as lead, beryllium, copper, thorium, zinc, nickel, etc.
- Rare earth metal 0.40-4.0 Cadmium 005-1 .2 Calcium or aluminum 0.05-1 .0 Manganese 0.05-1.0 Silver 00.8 Zirconium 0-O.8 Silicon 00.3 Magnesium remainder Neodymium and yttrium are predominantly employed as the rare earth metal although other rare earth metals can be used.
- the above alloy is produced by the conventional method by preparing a charge consisting of pure metals and master alloys and melting the same.
- One of the advantages of the invention is that it provides an alloy having high chemico-physiological, mechanical and engineering properties.
- the ultimate strength of said alloy e 28 kg/mm and the yield point a 18 kglmm Employment of said alloy for joining bone fragments obviates the necessity of a second operation on the patient for the removal of foreign fastening means (pins, nails, etc.) since said alloy is completely absorbed without the accumulation of gas.
- the stimulation of callus formation promotes the pateients rapid recovery.
- EXAMPLE 1 Illustrates an alloy of the following composition, wt.%:
- EXAMPLE 2 Illustrates an alloy of the following composition, wt.%:
- a bone fastening device for the fixation of bone fragments, constructed of an alloy, consisting essen tially of, by wt.%:
- Rare earth element 0.4-4.0 Cadmium 0.05-2.22 An element selected from the group consisting of calcium and aluminum (-1 .0 Manganese ODS-0.5 Silver 00.8 Zirconium 0-0.8 Silicon O-0.3 Magnesium remainder 2.
- a device as in claim I which has the following composition by wt.%:
- a device as in claim 1 which has the following composition, by wt.%:
- a device as in claim 1 which has the following compositions, wt.%:
Abstract
A magnesium-base alloy for use in bone surgery which contains the following components, wt.%: Rare earth element 0.4-4.0 Cadmium 0.05-1.2 An element from the group consisting of calcium and aluminum 0.05-1.0 Manganese 0.05.05 Silver 0-0.8 Zirconium 0-0.8 Silicon 0-0.3 Magnesium remainder
Description
waited States Patent Stroganov et a1.
[54] MAGNESIUM-BASE ALLOY FOR USE IN BONE SURGERY [72] Inventors: Genrikh Borisovich Stroganov, 2
Voikovsky proezd, 1, kv. 29; Evgeny Mikhailovich Savitsky, ulitsa Dmitria Ulyanova, 3, kv. 13; Nina Mikhailovna Tikhova, Frunzenskaya naberezhnaya, 38/1, kv. 394; Vera Fedorovna Terekhova, Belyaevo- Bogorodskoe, kvartal 48, korpus 23, kv. 235; Mstislav Vasilievich Volkov, 1 Stroitelnaya ulitsa, 6, korpus 5, kv. 10; Konstantin Mitrofanovich Sivash, B. Pirogovskaya ulitsa,
37/43 A, kv. 49; Vladislav Sergeevich Borodkin, Shelepikha, 5 ulitsa, 6/8, kv. 91, all of, Moscow, USSR.
[22] Filed: Sept. 15, 1969 [21] Appl. No.: 858,149
[52] US. Cl. ..128/92 B, 75/168 R, 75/168 M, 75/168 .1, 128/92 BA, 128/92 BB, 128/92 BC, 128/92 C [51] Int. Cl. ..C22c 23/00, A61f 5/01 [58] Field of Search..75/l68; 128/92 R, 92 B, 92 BB, 128/92 BA, 92 BC, 92 C, 92 CA, 92 D; 3/1
[ 51 Aug. 29, 1972 2,221,319 11/1940 Altwicker et a] ..75/168 B 2,549,955 4/1951 Jessup et a]. ..75/168 J OTHER PUBLICATIONS Annals of Surgery, Vol. 105, No. 6, June 1937, pp. 919, 920 & 938.
Primary ExaminerCharles N. Lovell Att0rneyWaters, Roditi, Schwartz & Nissen [57] ABSTRACT A magnesium-base alloy for use in bone surgery which contains the following components, wt.%:
Rare earth element 0.4-4.0 Cadmium 005-1 .2 An element from the group consisting of calcium and aluminum 0.05-1 .0 Manganese 0.05-.05 Silver 0-0.8 Zirconium 0-0.8 Silicon 0-0.3 Magnesium remainder 5 Claims, N0 Drawings MAGNES-BASE ALLOY FOR USE IN BONE SURGERY The present invention relates to magnesium-base alloys employed as a joining and fixation material in bone surgery.
One of the main problems in the operative treatment of bone fractures is finding a material for fixation means which is sufficiently strong, is absorbed after the completion of union and stimulates callus formation. The search for such a material has been made predominantly among organic substances although there are isolated reports of the study and use of inorganic materials, particularly metals.
Magnesium was first employed for osteosynthesis by Lambotte in 1907. In fracture of the bones of the lower leg a magnesium plate secured with gold-plate steel nails was used, but in 8 days the plate disintegrated with the formation of a large amount of gas under the skin. In spite of Lambottes failure, study of the effect of magnesium on the surrounding tissue and the body as a whole continued.
An attempt to use pure magnesium for osteosynthesis was unsuccessful because magnesium pins disintegrated so quickly that they were unsuitable for the fixation of bone fragments; nevertheless, clinical, X-ray and histological investigations demonstrated that pure magnesium introduced into the body in the form of a pin has no harmful effect.
Attempts were made to dust bone transplants with magnesium and calcium in vacuum and then graft them in the patients body. It was found that magnesium and calcium promoted rapid restoration of the entirety of the bone, this taking place 3 months sooner than when an untreated autotransplant was employed. Said method, however, is laborious and requires drainage for drawing off the gas formed.
Magnesium alloys with other metals have also been tried. Verbrugge used an alloy consisting of 92 percent magnesium and 8 percent aluminum; E. Bride reported the use of an alloy consisting of 95 percent magnesium, 4.7 percent aluminum and 0.3 percent manganese; M.S. Znamensky used an alloy consisting of 97.3 percent magnesium, 2.5 percent aluminum and 0.2 percent beryllium; B.I. Klepatsky tried an alloy consisting of 82.8 percent magnesium, 85 percent aluminum, 8.5 percent zinc and 0.2 percent manganese.
A review of the literature indicates that magnesium alloys employed for making fixation means dissolve completely in the bone and have no detrimental effect either locally or generally. However, the absorption of previously known magnesium alloys proceeds three or four times more rapidly than required from the standpoint of restoration of the entirety of the bone. Moreover, when said known alloys are used, drainage is necessary to remove the gas formed.
It is an object of the present invention to provide a magnesium-base alloy which has a rate of absorption slower than the process of bone consolidation, which does not involve vigorous evolution of gas and which has high mechanical strength.
It is another object of the invention to provide a magnesium-base alloy which meets the following requirements:
1. Ultimate strength a 28 kg/mm and yield point 2 18 kg/mm, i.e., the alloys mechanical strength shall exceed that of bone tissue;
2. The rate of absorption of the alloy compared to the rate of consolidation of the bone shall be such that at the moment of complete restoration of the bones entirety the alloy shall retain sufficient strength, i.e., the process of absorption shall be completed 1.5-2 months after knitting of the bone;
3. The rate of evolution of hydrogen during absorption of the alloy in the body shall be less or equal to the rate of absorption of hydrogen by the body.
4. The alloy shall contain elements which stimulate the growth of bone tissue, such as calcium and cadmium;
5. The alloy shall not contain elements which are harmful for the living organism, such as lead, beryllium, copper, thorium, zinc, nickel, etc.
The foregoing objects have been accomplished by the provision of a magnesium-base alloy which, accord ing to the invention, contains the following elements,
Rare earth metal 0.40-4.0 Cadmium 005-1 .2 Calcium or aluminum 0.05-1 .0 Manganese 0.05-1.0 Silver 00.8 Zirconium 0-O.8 Silicon 00.3 Magnesium remainder Neodymium and yttrium are predominantly employed as the rare earth metal although other rare earth metals can be used.
The above alloy is produced by the conventional method by preparing a charge consisting of pure metals and master alloys and melting the same.
One of the advantages of the invention is that it provides an alloy having high chemico-physiological, mechanical and engineering properties. The ultimate strength of said alloy e 28 kg/mm and the yield point a 18 kglmm Employment of said alloy for joining bone fragments obviates the necessity of a second operation on the patient for the removal of foreign fastening means (pins, nails, etc.) since said alloy is completely absorbed without the accumulation of gas. Moreover, the stimulation of callus formation promotes the pateients rapid recovery.
The following examples of variations in the composition of the alloy according to the invention are given by way of illustration.
EXAMPLE 1 Illustrates an alloy of the following composition, wt.%:
Neodymium 2.92 Cadmium 0.27 Calcium 0.24 Manganese 0.1 1 Magnesium remainder The above alloy has the following properties:
Ultimate strength 32.6 kg/mm Yield point 24.5 kg/mm Elongation 6.3%
Said alloy was tested in a physiological solution containing 0.9 wt.% NaCl, 0.02 wt.% KCl, 0.02 wt.% CaCl 0.002 wt.% Na CO and the remainder, distilled water. Evolution of hydrogen in 48 hours totalled 3.4 cm /cm The result of the test indirectly gives a conception of the process of absorption of the metal in the body.
EXAMPLE 2 Illustrates an alloy of the following composition, wt.%:
Neodymium 2.46 Cadmium 0. l 2 Aluminum 0.09 Manganese 0. l 4 Silicon 0.01 Magnesium remainder The above alloy has the following properties:
Ultimate strength 31.6 lrg/mm Yield point 25.3 ltg/mm" Elongation 3.7% Hydrogen evolution in physiological solution of Example I, 48 hrs. 2.1 em /cm EXAMPLE 3 Illustrates an alloy of the following composition, wt.%
Yttrium 1.6 Cadmium 0.25 Calcium 0.06
Silver 0.3 Manganese 0.08 Magnesium remainder The above alloy has the following properties:
Ultimate strength 28.4 kg/nim Yield point 23.6 kg/mm Elongation 5.5% Hydrogen evolution in physiological solution of Example 1, 48 hrs. [.6 cmVcrn EXAMPLE 4 Illustrates an alloy of the following composition, wt.%:
Neodymium Cadmium Calcium 0.08 Manganese 0.13 Zirconium 0.49 Magnesium remainder The above alloy has the following properties:
Ultimate strength 32.2 kglmm Yield point 21.8 kg/mrn Elongation 8.9% Hydrogen evolution in physiological solution of Example I, 48 hrs. 2.0 cm lcm MgCl, 34-40 KC] 25-36 NaCl CaCl s 8.0
CaF, -20
MgO 7-10 After melting and thoroughly mixing, the alloy was refined with the above flux and let stand for 15-20 minutes, after which it was poured at a temperature of 760-780C through a magnesite filter into moulds.
After preheating and hot pressing at 520-540C the blanks were cooled in the air after which they were artificially aged at 16021 0C for 16 hours.
The alloys thus produced were ready for use. Employment of the alloys specified in Examples 1, 2, 3 and 4 for joining bones in bone surgery demonstrated that all of said alloys possessed high mechanical and chemico-physiological properties. Clinical tests showed that said alloys were completely absorbed: pins 3 mm in diameter in 5 months and pins 8 mm in diameter in l 1 months. Bones knitted in 4 months.
F luoroscopic examination revealed no gas bubbles in the soft tissues during the entire period of absorption of said alloys.
Operative treatment of fractures by means of the I present alloy reduces the time required for union of the bone by 33-50 percent. In this respect the best showing was made by the alloy described in Example 2.
As is apparent from the figures cited, evolution of gas by the alloys described in Examples 1, 2, 3 and 4 is within the bodys absorptive capacity, since said capacity is 4.0-4.5 cm of gas from each sq.cm. of surface of the metal being absorbed per 48 hrs.
We claim:
1. A bone fastening device, for the fixation of bone fragments, constructed of an alloy, consisting essen tially of, by wt.%:
Rare earth element 0.4-4.0 Cadmium 0.05-2.22 An element selected from the group consisting of calcium and aluminum (-1 .0 Manganese ODS-0.5 Silver 00.8 Zirconium 0-0.8 Silicon O-0.3 Magnesium remainder 2. A device as in claim I which has the following composition by wt.%:
Neodymium 2.92 Cadmium 0.27 Calcium 0.24 Manganese 0.! 1 Magnesium remainder 3. A device as in claim 1 which has the following composition, by wt.%:
Neodymium 2.46 Cadmium 0. l 2 Aluminum 0.09 Manganese 0.14 Silicon 0.01 Magnesium remainder 4. A device as in claim 1 which has the following compositions, wt.%:
Yttrium L6 Cadmium 0.25 Calcium 0.06 Silver 0.3 Manganese 0.08 Magnesium remainder composition, wt.%:
Neodymium Cadmium Calcium Manganese Zirconium Magnesium remainder
Claims (4)
- 2. A device as in claim 1 which has the following composition by wt.%: Neodymium 2.92Cadmium 0.27Calcium 0.24Manganese 0.11Magnesium remainder
- 3. A device as in claim 1 which has the following composition, by wt.%: Neodymium 2.46Cadmium 0.12Aluminum 0.09Manganese 0.14Silicon 0.01Magnesium remainder
- 4. A device as in claim 1 which has the following compositions, wt.%: Yttrium 1.6Cadmium 0.25Calcium 0.06Silver 0.3Manganese 0.08Magnesium remainder
- 5. A device as in claim 1 which has the following composition, wt.%: Neodymium 1.8Cadmium 0.09Calcium 0.08Manganese 0.13Zirconium 0.49Magnesium remainder
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB41577/69A GB1237035A (en) | 1969-08-20 | 1969-08-20 | Magnesium-base alloy for use in bone surgery |
US85814969A | 1969-09-15 | 1969-09-15 | |
CH1405969A CH527276A (en) | 1969-08-20 | 1969-09-17 | Magnesium-based alloy for use in bone surgery |
FR6934613A FR2068401A1 (en) | 1969-08-20 | 1969-10-09 | |
DE19691953241 DE1953241B2 (en) | 1969-08-20 | 1969-10-22 | USE OF A MAGNESIUM ALLOY FOR BONE SURGERY |
Publications (1)
Publication Number | Publication Date |
---|---|
US3687135A true US3687135A (en) | 1972-08-29 |
Family
ID=27509491
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US858149A Expired - Lifetime US3687135A (en) | 1969-08-20 | 1969-09-15 | Magnesium-base alloy for use in bone surgery |
Country Status (5)
Country | Link |
---|---|
US (1) | US3687135A (en) |
CH (1) | CH527276A (en) |
DE (1) | DE1953241B2 (en) |
FR (1) | FR2068401A1 (en) |
GB (1) | GB1237035A (en) |
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Also Published As
Publication number | Publication date |
---|---|
FR2068401A1 (en) | 1971-08-27 |
GB1237035A (en) | 1971-06-30 |
DE1953241B2 (en) | 1971-10-28 |
DE1953241A1 (en) | 1971-05-13 |
CH527276A (en) | 1972-08-31 |
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