US3662517A - Syringe filling apparatus - Google Patents

Syringe filling apparatus Download PDF

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US3662517A
US3662517A US26683A US3662517DA US3662517A US 3662517 A US3662517 A US 3662517A US 26683 A US26683 A US 26683A US 3662517D A US3662517D A US 3662517DA US 3662517 A US3662517 A US 3662517A
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syringe
plunger
medicament
station
filling
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US26683A
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Edward R Tascher
Elmer A Koenig
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Sherwood Medical Co
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Sherwood Medical Industries Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests

Definitions

  • a syringe filling apparatus for automatically filling a plurality of syringes serially including an indexable turret having a lower support for holding a plurality of open syringe barrels and an upper support for holding a corresponding plurality of syringe plungers in aligned position with respect to the cylinder barrels, the turret assembly indexing each syringe to a filling station where medicament is dispensed into an open cylinder barrel and the medicament level in the barrel is sensed by a photo-sensitive circuit and medicament flow controlled in response thereto, the turret assembly indexing each syringe to a second station where a vertically reciprocable tool head pushes the syringe plunger from the upper turret support, and thereafter releasing it in the aligned cylinder barrel where the tool head exerts a pressure on the outer ring of the syringe plunge
  • the nurse or technician manually fills a plurality of syringes by inserting the needle of each syringe, one at a time, through the medicament bottle seal and thereafter withdrawing the syringe plunger until the desired level of medicament is observed in the syringe barrel at which time the technician terminates syringe plunger withdrawal and removes the syringe needle from the medicament container seal. This operation is repeated until medicament in the prefilled container is exhausted.
  • an automatic syringe filling machine is provided, particularly suitable for use in filling syringes at the hospital in an accurate, rapid and aseptic manner.
  • the present filling machine consists of a l2 syringe turret having a lower support for holding a plurality of syringe barrels and an upper support for holding a corresponding plurality of syringe plunger assemblies aligned but spaced above the open syringe barrels.
  • a drive and control mechanism is provided for indexing the turret and each syringe to three operating stations.
  • control circuit senses the presence of an empty syringe barrel signaling a dispensing circuit to begin filling the syringe, and when a predetermined level of medicament is in the syringe barrel a photo-sensitive circuit terminates the dispensing operation.
  • the control circuit initiates a turret indexing drive to index the filled syringe to the second station which is the plunger assembly set station.
  • a tool head reciprocates downwardly from above the upper turret support pushing a plunger as sembly from a holder, that includes a plurality of resilient fingers, in the upper support.
  • the action of the tool head is such that exerts a pressure on the outer ring of the plunger in such a manner as to captivate the plunger piston in the piston retainer sleeve.
  • the piston retainer sleeve at this point in the cycle holds the piston in a compressed position so that the plunger has a loose fit in the cylinder barrel.
  • the automatic control circuit controls the indexing mechanism to index the turret thereby positioning the first filled syringe at the third station which is the plunger piston release station.
  • the third station which is the plunger piston release station.
  • a cam arrangement is provided that cams the piston retaining sleeve upwardly releasing the piston in the cylinder barrel and sealing the medicament within the cylinder barrel.
  • the turret continues to index in this fashion and the syringes arrive one at a time at an unloading station where the operator of the machine removes the filled and assembled syringes.
  • an adjusting mechanism is provided for axially shifting the entire turret assembly on its frame. Since the photocell associated with the medicament level sensing circuit is stationary with respect to the frame, this adjustment shifts the syringe barrels with respect to the photocell so that the photocell sees" a different axial location in the syringe barrel and thus controls filling of the syringe barrels to varying levels as desired. This adjustment may be employed also to compensate for varying medicament viscosities.
  • the automatic control circuit provided in accordance with the present invention completely automatically cycles the filling machine.
  • a single index button is provided for indexing the turret primarily during initial loading of the machine until the first syringe arrives at the filling station, although this button may be employed in other situations.
  • the automatic control assumes complete control over all machine functions to properly fill the cylinder barrel, and actuate the plunger insert mechanism at the second station.
  • the control circuit is provided with inhibit circuitry which prevents turret indexing while the plunger insert mechanism is reciprocating and also prevents the plunger insert mechanism from operating while the turret is indexing.
  • FIG. I is a perspective view of a syringe filling machine with a disposable dispensing unit in operative position
  • FIG. 2 is a perspective view of the syringe filling machine shown in FIG. I with the syringe elements and disposable dispensing unit removed;
  • FIG. 3 is a top elevation, with the cover removed, of the syringe filling machine shown in FIG. I;
  • FIG. 4 is a side elevation, partly in section, of the syringe filling machine
  • FIG. 5 is a rear elevation of the filling machine, with the cover removed, with parts broken away for clarity;
  • FIG. 6 is an enlarged fragmentary view of one of the upper turret support plunger holders
  • FIG. 7 is an enlarged fragmentary section of one of the upper turret support plunger holders
  • FIG. 8 is a subassembly view of the plunger assembly camming station
  • FIG. 9 is a subassembly illustration of the disposable dispensing unit in relation to a syringe barrel shown schematically at the filling station;
  • FIG. 10 is an enlarged fragmentary section of the disposable dispensing unit container cap
  • FIG. II is a subassembly view of the disposable dispensing unit in a prepackaged condition
  • FIG. 12 is a schematic view of a syringe at the filling station
  • FIG. 13 is a schematic illustration of a syringe at the filling station showing the fluid level sensing photocell
  • FIG. 14 is a schematic illustration of a syringe at the plunger insert station
  • FIG. 15 is a schematic illustration of two syringes passing through the plunger camming station.
  • FIG. 16 is a schematic diagram of a solid state control circuit for the syringe filling machine.
  • an automatic syringe filling machine 10 is illustrated preferably adapted for use at a hospital.
  • the filling machine 10 is seen to include, generally, an indexable turret assembly 12 for holding the syringe parts, a disposable dispensing unit 14 for delivering medicament to open syringe barrels at a syringe filling station, a plunger insert assembly 16 for releasing the syringe plungers from the turret assembly support therefor, and a camming assembly 20 at a cam station for the purpose of camming the syringe plunger assembly to a condition where a sealing piston associated with the syringe plunger is released within the syringe barrel.
  • syringe is seen to consist of a syringe barrel 22 with a needle assembly (not shown) inserted within a sheath assembly 24.
  • the sheath assembly 24 is more fully described in the Robert Klohr et al application, Ser. No. 26,681, filed Apr. 8, I970, entitled Rigid Container Assembly for Syringe" and the application of Marvin A. Stumpf and Elmer A. Koenig, Ser. No. 860,223, filed Sept.
  • the syringe 20 is placed in the sheath 24 prior to insertion in the turret assembly 12.
  • the syringe 20 also includes a syringe plunger assembly 25 that includes an inner plunger 26 having a rubber piston 27 on the end thereof and a flange 28 at the upper end thereof.
  • a piston retainer sleeve 30 Surrounding the piston plunger 26 is a piston retainer sleeve 30 having a flange 31 at the upper end thereof.
  • the filling machine 10 is seen to include a lower frame member 36 and an upper frame member 38 spaced apart by vertical struts fastened to frame members 36 and 38 by fasteners 39 and 40', as shown in FIG. 5.
  • a vertical plate 42 Projecting upwardly from the upper frame member 38 is a vertical plate 42 separating the front and rear portions of the machine 10.
  • Suitable cover members 45, 46 and 47 are provided for enclosing the frame members and the portions of the mechanism which do not have to be manipulated by the operator in normal use.
  • the turret assembly 12 includes a stationary annular post member 50 threadedly fastened on the left-hand forward side (as viewed in FIG. I) of frame member 38 by fasteners 51.
  • Slidable in the post 50 is a turret support sleeve 52 that is carried by frame members 53. Suitable means are provided for preventing the rotation of sleeve 52 in post 50.
  • Frame member 53 is fixed by fasteners 54 to a parallel frame plate 55.
  • the frame member 55 is in turn supported vertically by threaded member 58 threadedly received in a boss 59 carried by the plate 55.
  • turret drive shaft 61 Rotatably mounted in the sleeve 52 is turret drive shaft 61 supported for rotation in bearings 62 and 63.
  • Shaft 61 has a projection 65 extending vertically from the level of bearing 62 which is keyed to a lower wheel-like turret member 67.
  • Fastened by suitable threaded fasteners to the lower turret member 67 is an upper turret member 68 which is annular in configuration.
  • the lower turret member 67 has an upper annular portion 72 from which projects an annular plate 73 having a plurality of conical apertures 75 that are adapted to receive syringe barrel flange 77 as shown in FIG. l2.
  • a radial slot 78 is provided associated with each of the conical recesses 75 to permit insertion of the cylinder barrel.
  • annular support plate 79 Suspended from support plate 73 is a similar annular support plate 79 having a plurality of stepped annular recesses 80 therein aligned with the conical recesses 75.
  • the annular recesses 80 are sized to receive the enlarged portion of the sheath 24 shown in FIG. 12, and radial slots 82 are provided associated with each of the recesses 80 to permit clearance for the lower portion of the sheath 24 during loading and unload ing of the syringe in the turret.
  • the lower support plate 79 is suspended by integral struts 83 shown clearly in FIGS. 2 and 4.
  • the upper turret support plate 68 has a plurality of stepped openings 85 therein (see FIG. 4) in annular array, and in alignment with and corresponding in number to the conical recesses 75 in plate 73 and the stepped recesses in the lower plate 79.
  • stepped recesses 85 Seated within the stepped recesses 85, as best shown in FIGS. 6 and 7 are plunger holders 87, constructed of a resilient plastic material.
  • the plunger holders 87 have an annular portion 88 seated within the stepped bore and four arcuate, generally radially extending cradle fingers 90 which project approximately to the diameter of syringe plunger sleeve 30 as shown in FIG. 7.
  • the plunger holders 87 hold plungers 25 by engaging the underside of the sleeve flanges 31. Fingers 90 have sufficient resiliency so that when the upper surface of the flange 31 is pushed downwardly by the plunger assembly, described in more detail below, the flange 31 will force the resilient fingers 90 downwardly permitting the plunger 25 to be released from holder 87.
  • a turret indexing motor 92 is provided shown clearly in FIG. 4.
  • Motor 92 is carried by the underside and affixed to a gearbox 94 which is fastened to the underside of turret frame member 55.
  • Gearbox 94 provides a suitable reduction in speed from the output shaft of motor 92.
  • Gearbox 94 has an output shaft 96 which drives a cam wheel 98 of a Geneva assembly 100.
  • the Geneva assembly assures the proper indexing movement of the turret 12 under the essentially constant speed rotation of motor 92. It should be understood, however, that motor 92 is turned on and off, however, at the end of each indexing movement.
  • the Geneva movement includes cam member 98 having a plurality of pins 102 projecting upwardly therefrom which enter cam slots in a star wheel 103 affixed to the lower end of turret drive shaft 61.
  • Star wheel 103 has the conventional shape in Geneva assemblies and includes a plurality of generally radial slots (not shown) into which the pins 102 enter and slide driving the wheel 103 and shaft 61 to succeeding index positions.
  • a microswitch 105 is provided between frame members 55 and 53, as shown in FIG. 4, for sensing the position of the indexing motor cam 98 to control the indexing motor 92 as well as the plunger assembly as will appear more clearly in the hereinafter described control circuit.
  • a syringe barrel filling station I10 is provided as shown in FIGS. 1, 3 and 4 and is seen to include a vertical support member 112 fixed to the turret frame plate 53 as shown in FIG. 4 and extending through and slidable within a grommet 115 in the main upper frame member 38.
  • Vertical support 112 extends approximately to support plate 73 and has connected thereto a generally, horizontally extending nozzle support member 117 as shown in FIGS. 1 and 3.
  • the nozzle support member 117 releasably holds a noule as shown in FIG. 9 in a manner such that medicament issuing from the noule does not in any way contact the nozzle support.
  • a pneumatic pump 119 is provided in the rear of machine 12 fixed to the upper main frame member 38 as shown in FIG. 3. Pump 119 is driven by a motor 120 and also carried by the frame 38. It should be understood that pump “9 is an air pump and that no medicament is conveyed through the pump eliminating the possibility of pump contamination by medicament.
  • a pump inlet fitting 122 is fixed within vertical wall 42 and opens to the front of the machine permitting ambient air to be drawn into the pump 119.
  • Interconnecting fitting 122 with pump fitting 123 is a flexible tube 124.
  • Pump outlet fitting 126 is interconnected to a pump outlet fitting 128 also on the front panel 42 by tubing section 130.
  • Fitting 128 may have a check valve associated therewith only permitting flow from the fitting 128. In this manner the inadvertent reversal of flow and drawing of medicament into the pump through tube 130 may be prevented.
  • a suitable air filter may be provided associated with inlet line 124 if desired.
  • the delivery of medicament from dispensing unit 14 to the filling station 110 is controlled by a pinch valve 140.
  • This valve operates generally by occluding flexible dispensing tube 142 and in this manner is not contaminated by contact with medicament.
  • the pinch valve 140 includes a stationary valve member 143 having a rearwardly opening aperture 144 therein for receiving a reciprocable slide valve member 146.
  • Valve member 143 also has a vertical opening 147 therethrough which receives the tube 142.
  • a threaded member 150 is provided threaded into the closed end of valve member 143 and engageable with the forward side of tube 142.
  • the slide member 146 is adapted to move forwardly and pinch the tubing 142 to a fully occluded position, preventing flow through the tube.
  • the pinch valve member 146 is biased to its occluding position by coil spring 152 and selectively withdrawn to a valve open position by a solenoid 153 (FIGS. 3 and 5) fixed to the vertical plate 42 by a horizontally extending bracket member 155.
  • solenoid 153 When solenoid 153 is energized by the control circuit described below, the valve member 146 will be withdrawn partially from the stationary valve member 143 permitting the dispensing tube 142 to open initiating medicament flow to the nozzle 120 filling the syringe barrel at station 110.
  • the disposable dispensing unit 14 is shown clearly in FIG. 9 and is seen to include a prefilled disposable medicament bottle 160 which has at its open end as shown in FIG. a seal 161 held in position by a retainer 162.
  • the prefilled medicament bottle 160 is by itself a conventional container. After the supply of medicament in bottle 160 is exhausted the bottle is thrown away.
  • Cap 164 has a counterbore 165 therein slidable over the retainer 162 during capping of the bottle 160.
  • Cap 164 has two angular connectors 167 and 168 molded integrally therewith.
  • the connectors are metal tubes having projecting beveled ends 169 and 170, respectively, which pierce the seal 161 as the cap 164 is placed on the end of the container. While the cap 164 may be readily removed from the bottle 160, although they are generally thrown away together, the friction between connectors 167, 168 and the seal 161 nor mally retains the cap 164 and bottle 160 together as a unit.
  • cap 164 has an annular recess 172 which is releasably but snuggly engaged by spaced tracks 174 and 176 formed integrally in the frame panel 42 as shown in FIGS. 1, 2 and 10. In this manner the cap 164 and bottle 160 may be readily inserted and held on panel 42, as well as easily removed therefrom after dispensing the medicament in the bottle 160.
  • the cap 164 has integral projections 178 and 179 surrounding the connector tubes 167 and 168, which serve as fittings for dispensing tube 142 and air pressure tube 181.
  • the opposite end of tube 181 is releasably connected to the pump outlet fitting 128 on the front panel 42.
  • the other tube extending from cap 164 i.e. dispensing tube 142, has a stepped nozzle 120 formed integrally on the end thereof.
  • cap 164 and tubes 142 and 181 are, prior to use, prepackaged in a flexible plastic aseptic container 183.
  • the dispensing unit will remain in an aseptic condition until just prior to use when the container 183 is opened.
  • a container 183 is opened and a new dispensing unit withdrawn therefrom.
  • Cap 164 is pushed over the end of the bottle 160 piercing seal 161 with the sharp connector ends 169 and 170.
  • Tube 181 is then connected to the pump outlet fitting 128 and the dispensing tube 142 is threaded through opening 147 in pinch valve 140.
  • Nozzle is then inserted within the nozzle holder 117 and the dispensing unit is ready for operation.
  • a suitable circuit is provided for energizing solenoid 153 at this time to permit the insertion of tubing 142, as will appear below in the description of the control circuit of FIG. 16.
  • pump motor 120' When the power supply of the machine 10 is turned on by a button 183 on the front of the machine 10, pump motor 120' begins pumping air through passage 130, through tube 181 and into the container bottle through connector 168. This pressurizes the bottle tending to force medicament through outlet tube 142. At this time, however, valve would be closed preventing the flow of medicament to the open syringe at the filling station 110. As each syringe moves into the loading station 110, the valve 140 is automatically opened for a time sufficient to fill the syringe barrel to a predeten'nined level and then the valve is closed preventing further flow.
  • Bottle 160 and cap 164 are then removed from the tracks 174 and 176 and the entire unit may be thrown away. If the bottle 160 is not empty, cap 164 may be removed therefrom retaining bottle 160 for later use with a new dispensing unit 14, if desired.
  • a photo-sensitive circuit including a light 186 as shown in FIG. 13 and a photocell 188.
  • the light 186 is mounted on the post 50. which is stationary, adjacent filling station 110 while the photocell 188 is positioned on the opposite side of the syringe barrel at the filling station. Such a location is shown schematically at 189 in FIG. 3 wherein the photocell receives a signal from light 186 through passage 190 in the frame 42.
  • photocell 188 turns on whenever an unfilled syringe barrel 22 arrives at filling station 110, controlling the valve 140 to dispense medicament into the syringe barrel.
  • the photocell turns off which effects the closure of valve 140 and the termination of the flow of medicament to the syringe barrel.
  • the threaded member 58 which vertically supports the turret assembly, has a worm gear 194 rotatably fixed to the lower end thereof slidably engaging a thrust washer 196 on the lower frame member 36.
  • Member 58 has a lower projecting portion 198 which extends through frame 36 and is held in position by a retainer assembly 200.
  • a suitable hearing may be provided in frame member 36 for supporting the lower end portion 198 of the threaded member 58.
  • worm gear 194 causes threaded member 58 to rotate vertically in boss 59 adjusting the entire turret assembly including frame members 53, 55, sleeve 52, lower support member 67, upper support member 68, and nozzle support 112.
  • a worm wheel 202 is provided mounted in bearing bosses 204 and 206 as shown in FIG. 5.
  • Gear 202 is rotated by rod 210 which extends through a bearing boss 212 from the main machine housing, and carries a manual rotating knob 214 on the distal end thereof as shown in FIGS. 1 and 5.
  • the vertical positioning of the syringe at the filling station 110 may be adjusted with respect to the light 186 and photocell 188 both of which are stationary with respect to the frame and do not adjust vertically with the turret.
  • the plunger insert mechanism 16 operates at a station indicated generally at 216 in FIGS. 2 and 3. As will appear hereinafter, the turret 12 indexes in a counterclockwise direction as viewed in FIG. 3 so that the plunger insert station 216 is the second operating station for each of the syringes.
  • a tool head 218, as shown in FIG. 4 is lowered engaging flange 31 on sleeve 30 of the syringe pushing the syringe plunger 25 from the holder 87.
  • the tool head 218 continues its stroke and captivates the piston 27 as shown in FIG. 12.
  • the tool head 16 includes an annular member having a plurality of fingers 220 on the lower end thereof.
  • the fingers 220 are sufi'lciently long so that the tool head 218 can fit over the piston plunger flange 28 without engaging the same.
  • Tool head 28 is reciprocated vertically by cam and follower assembly 222 driven by a plunger motor 223.
  • Tool head 218 is fastened to a horizontal bar 225 which is fixed to the upper end of a vertically reciprocable rod 226 slidable in a guide member 227 fixed to the upper surface of frame member 38.
  • a guide rod 229 is provided on guide member 227 for the purpose of preventing any pivotal movement of the toolhead 218 about rod 226.
  • Rod 226 has a lower bifurcated end 230 which is pivotally connected to one end of a link 232 (shown in section FIG. 4), the other end of the link being pivoted on a stationary support member 235.
  • a cam follower 236 Intermediate the ends of the link 232 and carried thereby is a cam follower 236 as shown in FIG. 5 slidable in a trackway 238 in a cylindrical cam 239.
  • Cam 239 is supported on a shaft 240 and driven by motor 223 through a gearbox 242 fixed to the upper surface of frame member 38.
  • the plunger cam 239 rotates a complete revolution for each reciprocation of plunger 218.
  • the plunger motor is deenergized after each revolution of cam 239.
  • a microswitch 244 is provided to sense the retracted position of toolhead 218.
  • the third and final station of the machine is the camming station at which the sleeve 30 of each syringe is raised with respect to the piston 27 releasing the plunger in the syringe barrel. It should be understood however that the camming station 20 does not shift the piston 27 axially within the barrel 22, but merely raises the sleeve 30 to permit the rubber piston 27 to expand within the barrel sealing medicament therein as well as placing the plunger in an operative condition.
  • an armate segmental support member 250 is provided at the camming station that extends above the lower support plate 73 but below the upper support plate 68.
  • Support 250 carries an arcuate tapered camming channel 252 having a slot 253 in the lower channel portion that has a sufficient width to receive the sleeve 30 but is smaller than the diameter of the sleeve flange 3!.
  • Guides 255 and 256 fixed to the cam member 252 may extend toward station 216 as shown in FIG. 3 to guide the sleeve 30 into the camming channel 252. As seen in FIG.
  • the camming channel has an upper surface 254 and a lower surface 258 which converge toward the exist end 259 of the channel.
  • the upper portion 254 of the channel serves to hold the piston plunger flange 28 while the lower portion 258 cams the sleeve flange 31 upwardly until flush with the plunger piston flange 28 as shown in the right-hand syringe in FIG. 15.
  • the partially sheathed syringes may be removed by the technician.
  • the empty syringes are loaded into the turret approximately at location 270 shown in FIG. 1 by loading the sheathed barrels in lower support members 73 and 79 and the plunger assemblies in the upper turret plate 68.
  • Button 278 is provided for actuating solenoid 153 independently of the automatic control to permit opening valve 140 for the purpose of inserting the tube 142 therein.
  • the operator then depresses a manual index button 272 which indexes the turret 12 to the next station. With the turret indexed one increment, the operator then loads another barrel and plunger, and thereafter presses the manual index button 272 again indexing the turret one position.
  • the operator continues loading syringes in the turret in this fashion and the only other operation required of the operator is the removal of the filled syringes from location 275, all of the remaining functions of the machine being performed entirely automatically.
  • the operator continues the manual depression of button 272 after loading each of the syringes until the first empty syringe arrives at the syringe loading station II7.
  • the presence of a syringe barrel is sensed by a suitable switch, described in more detail below, at the filling station 110, and an indication that the syringe is unfilled is provided by photocell 188 causing energization of solenoid 153 opening valve 140 initiating the filling of the syringe at station "0.
  • index motor 92 is energized rotating turret 12 to the next station placing the first syringe at plunger station 216 and the second syringe at the filling station 110.
  • the motor 223 is energized driving the tool head 218 downwardly and releasing a plunger assembly 25 in the aligned syringe barrel 22.
  • the piston 27 engages syringe barrel 22. The entrapped air builds up sufficient pressure to captivate the piston 27 which permits all but a small amount of residual air to escape.
  • a switch such as switch 244, in the control circuit is opened thereby which enables the circuit driving the turret index motor 92 so that upon receipt of a signal indicating that a cylinder barrel in station is filled, indexing will again occur.
  • the first syringe is then indexed into the camming station 20 whereat, after one indexing movement, it just begins to enter the cam channel 252. After two subsequent indexing movements as shown in FIG. 3, the first syringe will be completely through the cam member 252 wherein the plunger holding sleeve 30 is shifted upwardly releasing the piston within the cylinder barrel and completing the filling and plunger inserting operation of the machine.
  • This sequence of operation occurs in step-by-step fashion completely automatically, requiring only that the operator load syringes at station 270 and unload syringes at sta ion 275. Operation is discontinued by again pressing the power button 183 which terminates all functions of the filling device 10.
  • FIG. 16 an exemplary control circuit is illustrated for the present syringe filling machine 10.
  • an operator interface with this circuitry is provided by the three push button switches 183, 272 and 278 on the front of the machine, or control panel.
  • Button 183 is connected to a switch (not shown) which connects AC power to the motors 92, 223, and and dc supplies power for operation of the control circuitry shown.
  • the valve open button 278 is connected to close switch 316 for energizing solenoid coil 300 of solenoid 153 which is in the emitter leg of transistor 302. This permits the initial insertion of tube 142 through the valve 140.
  • the base of transistor 302 is connected through relay contact 304 which is closed when power turns ON, to the collector of transistor 306, and the base of transistor 306 is connected to a double-pole, single-throw switch 308 through resistor 310.
  • Switch 308 is located at the filling station 110 and is positioned so that contacts 312 are closed when a syringe barrel is in the filling station and contacts 311 are closed when no syringe barrel is in the station.
  • Contact 3]] of switch 308 is connected to positive DC voltage through resistor 314 and to ground through normally open solenoid control switch 316.
  • switch 308 assumes contact position 311 and solenoid switch 316 is open thereby keeping transistor 306 conducting and transistor 302 non-conducting, precluding actuation of solenoid coil 300 and maintaining the solenoid valve in its closed position.
  • button 272 is connected to actuate the manual index switch 318.
  • Switch 318 has one normally open contact 320 and one normally closed contact 322.
  • the closing of contact 320 causes transistor 324 to turn ON which in turn causes a high voltage to be applied to input 326 of OR gate 328.
  • the output of OR" gate 328 goes high causing transistor 330 to conduct supplying a high voltage to input 332 of AND gate 338.
  • the other inputs 334 and 336 of AND" gate 338 will normally be high at this stage of the sequence and thus the output of 338 will go high causing an output from "OR” gate 340 turning transistor 342 ON lighting bulb 344.
  • switch 384 which corresponds to switch 105 in FIG. 4, closes as soon as movement of the index cam 98 is initiated and thereafter switch 384 control index motor 92, the OR gate 340 providing only a triggering signal.
  • cam 98 indexes the turret one station, a suitable projection on the cam opens switch 384 terminating operation of the index motor 92 by turning off the transistor 342 and bulb 344.
  • switch 308 senses the presence of a syringe barrel and closes contacts 312.
  • the level photocell provides a signal to photo-resistor 362 indicating an unfilled syringe.
  • This turns, or maintains, transistor 364 OFF which, in turn, causes an output from OR" gate 328, turning transistor 358 OFF which through diode 360, switch 308, transistor 306 and transistor 302 activates solenoid coil 300 opening valve 140. This initiates the filling operation.
  • OR gate 358 The same signal from the output of OR" gate 358 is applied to the base of transistor 330 and turns it ON.
  • the output of transistor 330 is applied to input 332 of AND gate 338 turning gate 338 which turns OR" gate 340 ON.
  • OR gate 340 When the output of OR" gate 340 goes high, transistor 342 conducts and bulb 344 lights. The light from bulb 344 quits photo-resistor 346 and initiates the indexing motor 92 in the same manner as described above with respect to the manual index. Switch 384 holds the motor until the turret has made one indexing movement.
  • a syringe just filled is indexed to the plunger position 216.
  • the indexing motor cam 98 closes a microswitch 386, which may be adjacent switch 105, turning transistor 388 ON causing the output of OR" gate 390 to go high, causing transistor 392 to conduct which turns transistor 394 ON.
  • Bulb 396 in the emitter leg of transistor 394 then lights, activating photo-resistor 398 in the plunger motor circuitry, energizing the plunger motor 223 in the same manner that the indexing motor 92 is activated.
  • the plunger motor cam 239 closes switch 244 keeping the plunger motor activated for a full cycle. At the end of the cycle the plunger motor cam reopens switch 244 and the plunger motor cycle is complete.
  • transistor 402 Upon completion of the plunger cycle, transistor 402 turns OFF, and a previously applied indexing inhibit signal from the output of transistor 402 to input 334 of AND gate 338 is removed, an indexing is enabled.
  • switch 354 is located to sense the presence of a syringe barrel at station in the same manner as switch 308. Switch 354 is constructed so that contacts 356 are closed when the syringe is sensed at station 110 and contacts 357 are closed when no syringe is sensed at station 1 10.
  • a further feature in the control circuit, associated with the manual indexing function of manual index switch 320, is that upon closing of the manual index switch, a control is supplied to the anode of SCR 410 which drives the base of transistor 412 keeping the transistor 394 from conducting thereby precluding plunger operation.
  • a medicament filling device for a syringe of the type having a barrel member and a plunger comprising: frame means, a syringe filling station on said frame means for supporting a syringe to be filled, means for filling the syringe barrel through the breech end thereof, means for inserting the plunger after filling, the plunger having a resilient portion, said plunger including means compressing the resilient portion, and means releasing the resilient portion after insertion of the plunger.
  • a medicament filling device for a syringe of the type having a barrel member and a plunger comprising: frame means, a syringe filling station on said frame means for supporting a syringe to be filled, means for filling the syringe barrel through the breech end thereof, means for inserting the plunger after filling, said syringe plunger being of the type having a piston plunger and a sleeve, means on said frame means for shifting said sleeve to activate the piston plunger so that the sleeve releases the piston into the syringe barrel.
  • a medicament filling device for syringes of the type having a barrel member and a plunger comprising: frame means, a turret assembly on said frame means having a lower support for holding a plurality of syringe barrels, said turret assembly having an upper support for holding a plurality of syringe plungers above and in alignment with the syringe barrels, means on said frame means for filling said syringe barrels at a predetermined first station, means on said frame means for inserting said plungers into said barrels at a predetermined second station, said plungers having a resilient portion and means for compressing the resilient portion, and means for releasing the resilient portion after insertion of the plunger.
  • a medicament filling device for syringes of the type hav ing 1 barrel member and a plunger comprising: frame means, a turret assembly on said frame means having a lower support for holding a plurality of syringe barrels, said turret assembly having an upper support for holding a plurality of syringe plungers above and in alignment with the syringe barrels, means on said frame means for filling said syringe barrels at a predetermined first station, means on said frame means for inserting said plungers into said barrels at a predetermined second station, said plungers each including a piston plunger of said sleeves and said piston plungers.
  • a medicament filling device for syringes of the type having a barrel member and a plunger as defined in claim 6. including means for shifting the turret assembly in a vertical direction.

Abstract

A syringe filling apparatus for automatically filling a plurality of syringes serially including an indexable turret having a lower support for holding a plurality of open syringe barrels and an upper support for holding a corresponding plurality of syringe plungers in aligned position with respect to the cylinder barrels, the turret assembly indexing each syringe to a filling station where medicament is dispensed into an open cylinder barrel and the medicament level in the barrel is sensed by a photo-sensitive circuit and medicament flow controlled in response thereto, the turret assembly indexing each syringe to a second station where a vertically reciprocable tool head pushes the syringe plunger from the upper turret support, and thereafter releasing it in the aligned cylinder barrel where the tool head exerts a pressure on the outer ring of the syringe plunger in a manner to captivate the plunger piston and thus vent the entrapped air, the turret assembly indexing each syringe to a third station where each syringe plunger, which includes a plunger piston retainer sleeve for releasing the piston, has its piston releasing sleeve cammed upwardly in a manner to release the plunger piston within the associated syringe barrel sealing medicament therein, there being also provided a mechanism for vertically adjusting the turret assembly with respect to the photo-sensitive medicament level detecting means to vary the level of medicament in the barrels as desired.

Description

United States Patent Tascher et al.
[ 1 May 16,1972
[54] SYRINGE FILLING APPARATUS [72] Inventors: Edward R. Tascher, Manchester; Elmer A.
Koenig, Kirkwood, both of Mo.
[73] Assignee: Sherwood Medical Industries Inc.
[22] Filed: Apr. 8, 1970 [21] Appl. No.: 26,683
3,245,194 4/l966 Carski 53/37 X 3,005,300 l0/l961 Shields... .....53/3 1 9 3,503,l l3 3/l970 Lagsdin ..29/208 B Primary Examiner-Robert L. Spruill Attorney-Hofgren, Wegner, Allen, Stellman & McCord ABSTRACT A syringe filling apparatus for automatically filling a plurality of syringes serially including an indexable turret having a lower support for holding a plurality of open syringe barrels and an upper support for holding a corresponding plurality of syringe plungers in aligned position with respect to the cylinder barrels, the turret assembly indexing each syringe to a filling station where medicament is dispensed into an open cylinder barrel and the medicament level in the barrel is sensed by a photo-sensitive circuit and medicament flow controlled in response thereto, the turret assembly indexing each syringe to a second station where a vertically reciprocable tool head pushes the syringe plunger from the upper turret support, and thereafter releasing it in the aligned cylinder barrel where the tool head exerts a pressure on the outer ring of the syringe plunger in a manner to captivate the plunger piston and thus vent the entrapped air, the turret assembly indexing each syringe to a third station where each syringe plunger, which includes a plunger piston retainer sleeve for releasing the piston, has its piston releasing sleeve cammed upwardly in a manner to release the plunger piston within the associated syringe barrel sealing medicament therein, there being also provided a mechanism for vertically adjusting the turret as sembly with respect to the photo-sensitive medicament level detecting means to vary the level of medicament in the barrels as desired.
9 Claims, 7 Drawing Figures ill; um
PATENTEum 15 I872 SHEET 3 0F 7- PATENTEU MAY 16 I972 SHEET 5 [IF 7 SYRINGE FILLING APPARATUS BACKGROUND OF THE PRESENT INVENTION There are a plurality of techniques employed in present day hospitals for filling syringes with medicament. One such technique involves the use of a prefilled medicament container having a seal over the open end thereof. The nurse or technician manually fills a plurality of syringes by inserting the needle of each syringe, one at a time, through the medicament bottle seal and thereafter withdrawing the syringe plunger until the desired level of medicament is observed in the syringe barrel at which time the technician terminates syringe plunger withdrawal and removes the syringe needle from the medicament container seal. This operation is repeated until medicament in the prefilled container is exhausted.
There are several disadvantages to this technique, one being the slowness in filling, another being the probability of inaccurate barrel filling resulting from technician error, and still another and perhaps the most important is the possibility of contamination. The contamination may result from the insertion of difi'erent needles into the same container seal and may also result from the manual handling of the syringes and needles by the technician.
It is therefore a primary object of the present invention to eliminate or ameliorate the problems in prior art syringe filling techniques by providing an automatic machine for filling syringes.
SUMMARY OF THE PRESENT INVENTION In accordance with the present invention an automatic syringe filling machine is provided, particularly suitable for use in filling syringes at the hospital in an accurate, rapid and aseptic manner. The present filling machine consists of a l2 syringe turret having a lower support for holding a plurality of syringe barrels and an upper support for holding a corresponding plurality of syringe plunger assemblies aligned but spaced above the open syringe barrels. A drive and control mechanism is provided for indexing the turret and each syringe to three operating stations.
At the first operating station the control circuit senses the presence of an empty syringe barrel signaling a dispensing circuit to begin filling the syringe, and when a predetermined level of medicament is in the syringe barrel a photo-sensitive circuit terminates the dispensing operation.
In response to the completion of the filling cycle, the control circuit initiates a turret indexing drive to index the filled syringe to the second station which is the plunger assembly set station. At this station a tool head reciprocates downwardly from above the upper turret support pushing a plunger as sembly from a holder, that includes a plurality of resilient fingers, in the upper support. The action of the tool head is such that exerts a pressure on the outer ring of the plunger in such a manner as to captivate the plunger piston in the piston retainer sleeve. The piston retainer sleeve at this point in the cycle holds the piston in a compressed position so that the plunger has a loose fit in the cylinder barrel. Thus when the plunger assembly contacts medicament, only a small amount of air is entrapped between the plunger assembly and the medicament.
Again in response to the completion of filling the next succeeding syringe, the automatic control circuit controls the indexing mechanism to index the turret thereby positioning the first filled syringe at the third station which is the plunger piston release station. At this station a cam arrangement is provided that cams the piston retaining sleeve upwardly releasing the piston in the cylinder barrel and sealing the medicament within the cylinder barrel. The turret continues to index in this fashion and the syringes arrive one at a time at an unloading station where the operator of the machine removes the filled and assembled syringes.
For the purpose of controlling the level of medicament within the cylinder barrels, an adjusting mechanism is provided for axially shifting the entire turret assembly on its frame. Since the photocell associated with the medicament level sensing circuit is stationary with respect to the frame, this adjustment shifts the syringe barrels with respect to the photocell so that the photocell sees" a different axial location in the syringe barrel and thus controls filling of the syringe barrels to varying levels as desired. This adjustment may be employed also to compensate for varying medicament viscosities.
The automatic control circuit provided in accordance with the present invention completely automatically cycles the filling machine. A single index button is provided for indexing the turret primarily during initial loading of the machine until the first syringe arrives at the filling station, although this button may be employed in other situations. In response to an unfilled syringe being present at the filling station, the automatic control assumes complete control over all machine functions to properly fill the cylinder barrel, and actuate the plunger insert mechanism at the second station. The control circuit is provided with inhibit circuitry which prevents turret indexing while the plunger insert mechanism is reciprocating and also prevents the plunger insert mechanism from operating while the turret is indexing.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. I is a perspective view of a syringe filling machine with a disposable dispensing unit in operative position;
FIG. 2 is a perspective view of the syringe filling machine shown in FIG. I with the syringe elements and disposable dispensing unit removed;
FIG. 3 is a top elevation, with the cover removed, of the syringe filling machine shown in FIG. I;
FIG. 4 is a side elevation, partly in section, of the syringe filling machine;
FIG. 5 is a rear elevation of the filling machine, with the cover removed, with parts broken away for clarity;
FIG. 6 is an enlarged fragmentary view of one of the upper turret support plunger holders;
FIG. 7 is an enlarged fragmentary section of one of the upper turret support plunger holders;
FIG. 8 is a subassembly view of the plunger assembly camming station;
FIG. 9 is a subassembly illustration of the disposable dispensing unit in relation to a syringe barrel shown schematically at the filling station;
FIG. 10 is an enlarged fragmentary section of the disposable dispensing unit container cap;
FIG. II is a subassembly view of the disposable dispensing unit in a prepackaged condition;
FIG. 12 is a schematic view of a syringe at the filling station;
FIG. 13 is a schematic illustration of a syringe at the filling station showing the fluid level sensing photocell;
FIG. 14 is a schematic illustration of a syringe at the plunger insert station;
FIG. 15 is a schematic illustration of two syringes passing through the plunger camming station; and
FIG. 16 is a schematic diagram of a solid state control circuit for the syringe filling machine.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT Referring to the drawings and more particularly FIGS. 1 to 5, an automatic syringe filling machine 10 is illustrated preferably adapted for use at a hospital. The filling machine 10 is seen to include, generally, an indexable turret assembly 12 for holding the syringe parts, a disposable dispensing unit 14 for delivering medicament to open syringe barrels at a syringe filling station, a plunger insert assembly 16 for releasing the syringe plungers from the turret assembly support therefor, and a camming assembly 20 at a cam station for the purpose of camming the syringe plunger assembly to a condition where a sealing piston associated with the syringe plunger is released within the syringe barrel.
To more clearly understand the construction and operation and advantages of the present device, it will be helpful to describe one type of syringe that the present device is particularly suitable for filling and assembling. Referring to FIG. 12, syringe is seen to consist of a syringe barrel 22 with a needle assembly (not shown) inserted within a sheath assembly 24. The sheath assembly 24 is more fully described in the Robert Klohr et al application, Ser. No. 26,681, filed Apr. 8, I970, entitled Rigid Container Assembly for Syringe" and the application of Marvin A. Stumpf and Elmer A. Koenig, Ser. No. 860,223, filed Sept. 23, 1969, entitled Breech Loaded Syringe and Method of Breech-loading Syringes," both assigned to the assignee of the present invention. It should be noted that the syringe 20 is placed in the sheath 24 prior to insertion in the turret assembly 12. The syringe 20 also includes a syringe plunger assembly 25 that includes an inner plunger 26 having a rubber piston 27 on the end thereof and a flange 28 at the upper end thereof. Surrounding the piston plunger 26 is a piston retainer sleeve 30 having a flange 31 at the upper end thereof.
In the position shown in FIG. 12 the sleeve 31 is in its active position surrounding and compressing the piston 27. Sleeve 30 has a clearance when inserted within the syringe barrel 22 so that it will slide into the barrel with a loose fit that will permit the venting of entrapped air. As will appear hereinafter, alter plunger 25 is inserted within a filled cylinder barrel 22, the sleeve 30 is raised releasing piston 27 and permitting the resilient piston to expand within the syringe barrel 22, sealing medicament therein. For a more detailed description of the construction syringe 20 reference should be made to the copending applications of Robert Klohr et al and Marvin A. Stumpf et al, cited above.
Returning to a description of the filling mechanism in more detail, and particularly FIGS. 1 to 5, the filling machine 10 is seen to include a lower frame member 36 and an upper frame member 38 spaced apart by vertical struts fastened to frame members 36 and 38 by fasteners 39 and 40', as shown in FIG. 5. Projecting upwardly from the upper frame member 38 is a vertical plate 42 separating the front and rear portions of the machine 10. Suitable cover members 45, 46 and 47 are provided for enclosing the frame members and the portions of the mechanism which do not have to be manipulated by the operator in normal use.
As shown clearly in FIG. 4, the turret assembly 12 includes a stationary annular post member 50 threadedly fastened on the left-hand forward side (as viewed in FIG. I) of frame member 38 by fasteners 51. Slidable in the post 50 is a turret support sleeve 52 that is carried by frame members 53. Suitable means are provided for preventing the rotation of sleeve 52 in post 50. Frame member 53 is fixed by fasteners 54 to a parallel frame plate 55. The frame member 55 is in turn supported vertically by threaded member 58 threadedly received in a boss 59 carried by the plate 55.
Rotatably mounted in the sleeve 52 is turret drive shaft 61 supported for rotation in bearings 62 and 63. Shaft 61 has a projection 65 extending vertically from the level of bearing 62 which is keyed to a lower wheel-like turret member 67. Fastened by suitable threaded fasteners to the lower turret member 67 is an upper turret member 68 which is annular in configuration.
Referring to FIG. 2, the lower turret member 67 has an upper annular portion 72 from which projects an annular plate 73 having a plurality of conical apertures 75 that are adapted to receive syringe barrel flange 77 as shown in FIG. l2. A radial slot 78 is provided associated with each of the conical recesses 75 to permit insertion of the cylinder barrel.
Suspended from support plate 73 is a similar annular support plate 79 having a plurality of stepped annular recesses 80 therein aligned with the conical recesses 75. The annular recesses 80 are sized to receive the enlarged portion of the sheath 24 shown in FIG. 12, and radial slots 82 are provided associated with each of the recesses 80 to permit clearance for the lower portion of the sheath 24 during loading and unload ing of the syringe in the turret. The lower support plate 79 is suspended by integral struts 83 shown clearly in FIGS. 2 and 4.
The upper turret support plate 68 has a plurality of stepped openings 85 therein (see FIG. 4) in annular array, and in alignment with and corresponding in number to the conical recesses 75 in plate 73 and the stepped recesses in the lower plate 79. Seated within the stepped recesses 85, as best shown in FIGS. 6 and 7 are plunger holders 87, constructed of a resilient plastic material. The plunger holders 87 have an annular portion 88 seated within the stepped bore and four arcuate, generally radially extending cradle fingers 90 which project approximately to the diameter of syringe plunger sleeve 30 as shown in FIG. 7. The plunger holders 87 hold plungers 25 by engaging the underside of the sleeve flanges 31. Fingers 90 have sufficient resiliency so that when the upper surface of the flange 31 is pushed downwardly by the plunger assembly, described in more detail below, the flange 31 will force the resilient fingers 90 downwardly permitting the plunger 25 to be released from holder 87.
In the exemplary turret construction shown there are holders for the barrel and plunger assemblies of I2 syringes, although, as will appear clear to those skilled in this art, a greater or lesser number of plunger holding locations may be provided.
For the purpose of indexing the turret I2, a turret indexing motor 92 is provided shown clearly in FIG. 4. Motor 92 is carried by the underside and affixed to a gearbox 94 which is fastened to the underside of turret frame member 55. Gearbox 94 provides a suitable reduction in speed from the output shaft of motor 92. Gearbox 94 has an output shaft 96 which drives a cam wheel 98 of a Geneva assembly 100.
The Geneva assembly assures the proper indexing movement of the turret 12 under the essentially constant speed rotation of motor 92. It should be understood, however, that motor 92 is turned on and off, however, at the end of each indexing movement.
The Geneva movement includes cam member 98 having a plurality of pins 102 projecting upwardly therefrom which enter cam slots in a star wheel 103 affixed to the lower end of turret drive shaft 61. Star wheel 103 has the conventional shape in Geneva assemblies and includes a plurality of generally radial slots (not shown) into which the pins 102 enter and slide driving the wheel 103 and shaft 61 to succeeding index positions. A microswitch 105 is provided between frame members 55 and 53, as shown in FIG. 4, for sensing the position of the indexing motor cam 98 to control the indexing motor 92 as well as the plunger assembly as will appear more clearly in the hereinafter described control circuit.
A syringe barrel filling station I10 is provided as shown in FIGS. 1, 3 and 4 and is seen to include a vertical support member 112 fixed to the turret frame plate 53 as shown in FIG. 4 and extending through and slidable within a grommet 115 in the main upper frame member 38. Vertical support 112 extends approximately to support plate 73 and has connected thereto a generally, horizontally extending nozzle support member 117 as shown in FIGS. 1 and 3.
The nozzle support member 117 releasably holds a noule as shown in FIG. 9 in a manner such that medicament issuing from the noule does not in any way contact the nozzle support.
For the purpose of supplying medicament to the nozzle I20 and from the nozzle into an empty syringe at station III], a pneumatic pump 119 is provided in the rear of machine 12 fixed to the upper main frame member 38 as shown in FIG. 3. Pump 119 is driven by a motor 120 and also carried by the frame 38. It should be understood that pump "9 is an air pump and that no medicament is conveyed through the pump eliminating the possibility of pump contamination by medicament.
A pump inlet fitting 122 is fixed within vertical wall 42 and opens to the front of the machine permitting ambient air to be drawn into the pump 119. Interconnecting fitting 122 with pump fitting 123 is a flexible tube 124. Pump outlet fitting 126 is interconnected to a pump outlet fitting 128 also on the front panel 42 by tubing section 130. Fitting 128 may have a check valve associated therewith only permitting flow from the fitting 128. In this manner the inadvertent reversal of flow and drawing of medicament into the pump through tube 130 may be prevented. A suitable air filter may be provided associated with inlet line 124 if desired.
The delivery of medicament from dispensing unit 14 to the filling station 110 is controlled by a pinch valve 140. This valve operates generally by occluding flexible dispensing tube 142 and in this manner is not contaminated by contact with medicament. The pinch valve 140 includes a stationary valve member 143 having a rearwardly opening aperture 144 therein for receiving a reciprocable slide valve member 146. Valve member 143 also has a vertical opening 147 therethrough which receives the tube 142. For the purpose of holding the tube 142 in position within opening 147 a threaded member 150 is provided threaded into the closed end of valve member 143 and engageable with the forward side of tube 142. The slide member 146 is adapted to move forwardly and pinch the tubing 142 to a fully occluded position, preventing flow through the tube.
The pinch valve member 146 is biased to its occluding position by coil spring 152 and selectively withdrawn to a valve open position by a solenoid 153 (FIGS. 3 and 5) fixed to the vertical plate 42 by a horizontally extending bracket member 155. Thus when solenoid 153 is energized by the control circuit described below, the valve member 146 will be withdrawn partially from the stationary valve member 143 permitting the dispensing tube 142 to open initiating medicament flow to the nozzle 120 filling the syringe barrel at station 110.
The disposable dispensing unit 14 is shown clearly in FIG. 9 and is seen to include a prefilled disposable medicament bottle 160 which has at its open end as shown in FIG. a seal 161 held in position by a retainer 162. The prefilled medicament bottle 160 is by itself a conventional container. After the supply of medicament in bottle 160 is exhausted the bottle is thrown away.
Included in the dispensing unit 14 is a plastic container cap 164 having a counterbore 165 therein slidable over the retainer 162 during capping of the bottle 160. Cap 164 has two angular connectors 167 and 168 molded integrally therewith. The connectors are metal tubes having projecting beveled ends 169 and 170, respectively, which pierce the seal 161 as the cap 164 is placed on the end of the container. While the cap 164 may be readily removed from the bottle 160, although they are generally thrown away together, the friction between connectors 167, 168 and the seal 161 nor mally retains the cap 164 and bottle 160 together as a unit.
The exterior of cap 164 has an annular recess 172 which is releasably but snuggly engaged by spaced tracks 174 and 176 formed integrally in the frame panel 42 as shown in FIGS. 1, 2 and 10. In this manner the cap 164 and bottle 160 may be readily inserted and held on panel 42, as well as easily removed therefrom after dispensing the medicament in the bottle 160.
The cap 164 has integral projections 178 and 179 surrounding the connector tubes 167 and 168, which serve as fittings for dispensing tube 142 and air pressure tube 181. The opposite end of tube 181 is releasably connected to the pump outlet fitting 128 on the front panel 42. As described above, the other tube extending from cap 164, i.e. dispensing tube 142, has a stepped nozzle 120 formed integrally on the end thereof.
As seen in FIG. 1], cap 164 and tubes 142 and 181 are, prior to use, prepackaged in a flexible plastic aseptic container 183. Thus the dispensing unit will remain in an aseptic condition until just prior to use when the container 183 is opened.
In readying the filling machine 10 for operation and with the use of each new medicament container 160, a container 183 is opened and a new dispensing unit withdrawn therefrom. Cap 164 is pushed over the end of the bottle 160 piercing seal 161 with the sharp connector ends 169 and 170. Tube 181 is then connected to the pump outlet fitting 128 and the dispensing tube 142 is threaded through opening 147 in pinch valve 140. Nozzle is then inserted within the nozzle holder 117 and the dispensing unit is ready for operation. A suitable circuit is provided for energizing solenoid 153 at this time to permit the insertion of tubing 142, as will appear below in the description of the control circuit of FIG. 16.
When the power supply of the machine 10 is turned on by a button 183 on the front of the machine 10, pump motor 120' begins pumping air through passage 130, through tube 181 and into the container bottle through connector 168. This pressurizes the bottle tending to force medicament through outlet tube 142. At this time, however, valve would be closed preventing the flow of medicament to the open syringe at the filling station 110. As each syringe moves into the loading station 110, the valve 140 is automatically opened for a time sufficient to fill the syringe barrel to a predeten'nined level and then the valve is closed preventing further flow.
After the medicament in bottle is exhausted or if it is desired to change bottles to a different medicament, the tubing 142 is unthreaded from valve 140 and the tubing 181 is disconnected from pump outlet fitting 128. Bottle 160 and cap 164 are then removed from the tracks 174 and 176 and the entire unit may be thrown away. If the bottle 160 is not empty, cap 164 may be removed therefrom retaining bottle 160 for later use with a new dispensing unit 14, if desired.
For the purpose of controlling the level of medicament in the syringe barrel at the filling station 110 a photo-sensitive circuit is provided including a light 186 as shown in FIG. 13 and a photocell 188. The light 186 is mounted on the post 50. which is stationary, adjacent filling station 110 while the photocell 188 is positioned on the opposite side of the syringe barrel at the filling station. Such a location is shown schematically at 189 in FIG. 3 wherein the photocell receives a signal from light 186 through passage 190 in the frame 42. As will be described in more detail below, photocell 188 turns on whenever an unfilled syringe barrel 22 arrives at filling station 110, controlling the valve 140 to dispense medicament into the syringe barrel. When the level of medicament reaches the level of the window" of the photocell 188, the photocell turns off which effects the closure of valve 140 and the termination of the flow of medicament to the syringe barrel.
To vary the level of medicament within the syringe barrel 22, provision is made for vertically adjusting the entire turret 12. Toward this end and as shown clearly in FIG. 4, the threaded member 58 which vertically supports the turret assembly, has a worm gear 194 rotatably fixed to the lower end thereof slidably engaging a thrust washer 196 on the lower frame member 36. Member 58 has a lower projecting portion 198 which extends through frame 36 and is held in position by a retainer assembly 200. A suitable hearing may be provided in frame member 36 for supporting the lower end portion 198 of the threaded member 58. The rotation of worm gear 194 causes threaded member 58 to rotate vertically in boss 59 adjusting the entire turret assembly including frame members 53, 55, sleeve 52, lower support member 67, upper support member 68, and nozzle support 112.
To rotate the worm gear 194, a worm wheel 202 is provided mounted in bearing bosses 204 and 206 as shown in FIG. 5. Gear 202 is rotated by rod 210 which extends through a bearing boss 212 from the main machine housing, and carries a manual rotating knob 214 on the distal end thereof as shown in FIGS. 1 and 5.
By adjusting the height of the turret assembly 12, the vertical positioning of the syringe at the filling station 110 may be adjusted with respect to the light 186 and photocell 188 both of which are stationary with respect to the frame and do not adjust vertically with the turret.
The plunger insert mechanism 16 operates at a station indicated generally at 216 in FIGS. 2 and 3. As will appear hereinafter, the turret 12 indexes in a counterclockwise direction as viewed in FIG. 3 so that the plunger insert station 216 is the second operating station for each of the syringes.
Upon arrival at the plunger insert station 216, a tool head 218, as shown in FIG. 4, is lowered engaging flange 31 on sleeve 30 of the syringe pushing the syringe plunger 25 from the holder 87. As the plunger piston 27 engages the syringe barrel 22, the tool head 218 continues its stroke and captivates the piston 27 as shown in FIG. 12.
As seen in FIG. 4, the tool head 16 includes an annular member having a plurality of fingers 220 on the lower end thereof. The fingers 220 are sufi'lciently long so that the tool head 218 can fit over the piston plunger flange 28 without engaging the same. Tool head 28 is reciprocated vertically by cam and follower assembly 222 driven by a plunger motor 223.
Tool head 218 is fastened to a horizontal bar 225 which is fixed to the upper end of a vertically reciprocable rod 226 slidable in a guide member 227 fixed to the upper surface of frame member 38. A guide rod 229 is provided on guide member 227 for the purpose of preventing any pivotal movement of the toolhead 218 about rod 226. Rod 226 has a lower bifurcated end 230 which is pivotally connected to one end of a link 232 (shown in section FIG. 4), the other end of the link being pivoted on a stationary support member 235. Intermediate the ends of the link 232 and carried thereby is a cam follower 236 as shown in FIG. 5 slidable in a trackway 238 in a cylindrical cam 239. Cam 239 is supported on a shaft 240 and driven by motor 223 through a gearbox 242 fixed to the upper surface of frame member 38. The plunger cam 239 rotates a complete revolution for each reciprocation of plunger 218. The plunger motor is deenergized after each revolution of cam 239. Toward this end a microswitch 244 is provided to sense the retracted position of toolhead 218.
The third and final station of the machine is the camming station at which the sleeve 30 of each syringe is raised with respect to the piston 27 releasing the plunger in the syringe barrel. It should be understood however that the camming station 20 does not shift the piston 27 axially within the barrel 22, but merely raises the sleeve 30 to permit the rubber piston 27 to expand within the barrel sealing medicament therein as well as placing the plunger in an operative condition.
Toward this end, and as viewed in FIGS. 3, 4 and 8, an armate segmental support member 250 is provided at the camming station that extends above the lower support plate 73 but below the upper support plate 68. Support 250 carries an arcuate tapered camming channel 252 having a slot 253 in the lower channel portion that has a sufficient width to receive the sleeve 30 but is smaller than the diameter of the sleeve flange 3!. Guides 255 and 256 fixed to the cam member 252 may extend toward station 216 as shown in FIG. 3 to guide the sleeve 30 into the camming channel 252. As seen in FIG. 15, the camming channel has an upper surface 254 and a lower surface 258 which converge toward the exist end 259 of the channel. The upper portion 254 of the channel serves to hold the piston plunger flange 28 while the lower portion 258 cams the sleeve flange 31 upwardly until flush with the plunger piston flange 28 as shown in the right-hand syringe in FIG. 15.
After the partially sheathed syringes leave the camming station 20, they may be removed by the technician.
While the operation of the filling machine 10 is believed apparent from the above description, the following description will be helpful to summarize the operation.
After the operator loads the medicament dispenser 14 in the position and the power button 183 is depressed, the empty syringes are loaded into the turret approximately at location 270 shown in FIG. 1 by loading the sheathed barrels in lower support members 73 and 79 and the plunger assemblies in the upper turret plate 68. Button 278 is provided for actuating solenoid 153 independently of the automatic control to permit opening valve 140 for the purpose of inserting the tube 142 therein. The operator then depresses a manual index button 272 which indexes the turret 12 to the next station. With the turret indexed one increment, the operator then loads another barrel and plunger, and thereafter presses the manual index button 272 again indexing the turret one position. The operator continues loading syringes in the turret in this fashion and the only other operation required of the operator is the removal of the filled syringes from location 275, all of the remaining functions of the machine being performed entirely automatically. The operator continues the manual depression of button 272 after loading each of the syringes until the first empty syringe arrives at the syringe loading station II7. The presence of a syringe barrel is sensed by a suitable switch, described in more detail below, at the filling station 110, and an indication that the syringe is unfilled is provided by photocell 188 causing energization of solenoid 153 opening valve 140 initiating the filling of the syringe at station "0. When the level of the medicament in the syringe at the filling station reaches the photocell sensing level shown in FIG. 13, the signal from photocell I88 ceases causing the control circuit to deenergize solenoid 153 closing valve 140 and terminating the flow of medicament to the syringe.
In response to the completion of filling the first syringe, index motor 92 is energized rotating turret 12 to the next station placing the first syringe at plunger station 216 and the second syringe at the filling station 110. In response to the completion of indexing the motor 223 is energized driving the tool head 218 downwardly and releasing a plunger assembly 25 in the aligned syringe barrel 22. As the tool head 218 continues its downward stroke the piston 27 engages syringe barrel 22. The entrapped air builds up sufficient pressure to captivate the piston 27 which permits all but a small amount of residual air to escape.
Upon completion of the plunger cam 239, a switch, such as switch 244, in the control circuit is opened thereby which enables the circuit driving the turret index motor 92 so that upon receipt of a signal indicating that a cylinder barrel in station is filled, indexing will again occur.
The first syringe is then indexed into the camming station 20 whereat, after one indexing movement, it just begins to enter the cam channel 252. After two subsequent indexing movements as shown in FIG. 3, the first syringe will be completely through the cam member 252 wherein the plunger holding sleeve 30 is shifted upwardly releasing the piston within the cylinder barrel and completing the filling and plunger inserting operation of the machine. This sequence of operation occurs in step-by-step fashion completely automatically, requiring only that the operator load syringes at station 270 and unload syringes at sta ion 275. Operation is discontinued by again pressing the power button 183 which terminates all functions of the filling device 10.
Referring to FIG. 16 an exemplary control circuit is illustrated for the present syringe filling machine 10. As noted above, an operator interface with this circuitry is provided by the three push button switches 183, 272 and 278 on the front of the machine, or control panel. Button 183 is connected to a switch (not shown) which connects AC power to the motors 92, 223, and and dc supplies power for operation of the control circuitry shown. The valve open button 278 is connected to close switch 316 for energizing solenoid coil 300 of solenoid 153 which is in the emitter leg of transistor 302. This permits the initial insertion of tube 142 through the valve 140.
The base of transistor 302 is connected through relay contact 304 which is closed when power turns ON, to the collector of transistor 306, and the base of transistor 306 is connected to a double-pole, single-throw switch 308 through resistor 310. Switch 308 is located at the filling station 110 and is positioned so that contacts 312 are closed when a syringe barrel is in the filling station and contacts 311 are closed when no syringe barrel is in the station. Contact 3]] of switch 308 is connected to positive DC voltage through resistor 314 and to ground through normally open solenoid control switch 316.
At the beginning of operation of the machine, switch 308 assumes contact position 311 and solenoid switch 316 is open thereby keeping transistor 306 conducting and transistor 302 non-conducting, precluding actuation of solenoid coil 300 and maintaining the solenoid valve in its closed position.
To effect the step-by-step manual indexing during the initial loading of the machine by depressing button 272, as described above, button 272 is connected to actuate the manual index switch 318. Switch 318 has one normally open contact 320 and one normally closed contact 322. The closing of contact 320 causes transistor 324 to turn ON which in turn causes a high voltage to be applied to input 326 of OR gate 328. The output of OR" gate 328 goes high causing transistor 330 to conduct supplying a high voltage to input 332 of AND gate 338. The other inputs 334 and 336 of AND" gate 338 will normally be high at this stage of the sequence and thus the output of 338 will go high causing an output from "OR" gate 340 turning transistor 342 ON lighting bulb 344. The light from bulb 344 activates photo-resistor 346 which causes capacitor 348 to charge until neon bulb 350 fires causing triac 352 to cycle thereby activating the index motor 92, moving the turret to the next index position. Switch 384, which corresponds to switch 105 in FIG. 4, closes as soon as movement of the index cam 98 is initiated and thereafter switch 384 control index motor 92, the OR gate 340 providing only a triggering signal. After cam 98 indexes the turret one station, a suitable projection on the cam opens switch 384 terminating operation of the index motor 92 by turning off the transistor 342 and bulb 344.
When the first empty syringe is indexed over to the fill station 110, switch 308 senses the presence of a syringe barrel and closes contacts 312.
At the same time, the level photocell provides a signal to photo-resistor 362 indicating an unfilled syringe. This turns, or maintains, transistor 364 OFF which, in turn, causes an output from OR" gate 328, turning transistor 358 OFF which through diode 360, switch 308, transistor 306 and transistor 302 activates solenoid coil 300 opening valve 140. This initiates the filling operation.
When medicament in the syringe rises to the level of the photocell 188, photo-resistor 362 causes transistor 364 to turn ON which causes a high voltage to appear at input 382 of "OR" gate 328. The output of OR" gate 328 goes high turning transistor 358 ON, which through the solenoid control circuitry deactivates solenoid coil 300 closing the solenoid valve 140 as previously explained.
The same signal from the output of OR" gate 358 is applied to the base of transistor 330 and turns it ON. The output of transistor 330 is applied to input 332 of AND gate 338 turning gate 338 which turns OR" gate 340 ON. When the output of OR" gate 340 goes high, transistor 342 conducts and bulb 344 lights. The light from bulb 344 quits photo-resistor 346 and initiates the indexing motor 92 in the same manner as described above with respect to the manual index. Switch 384 holds the motor until the turret has made one indexing movement.
Upon completion of each indexing cycle, a syringe just filled is indexed to the plunger position 216. At this point the indexing motor cam 98 closes a microswitch 386, which may be adjacent switch 105, turning transistor 388 ON causing the output of OR" gate 390 to go high, causing transistor 392 to conduct which turns transistor 394 ON. Bulb 396 in the emitter leg of transistor 394 then lights, activating photo-resistor 398 in the plunger motor circuitry, energizing the plunger motor 223 in the same manner that the indexing motor 92 is activated. Upon activation of plunger motor 223, the plunger motor cam 239 closes switch 244 keeping the plunger motor activated for a full cycle. At the end of the cycle the plunger motor cam reopens switch 244 and the plunger motor cycle is complete.
Upon completion of the plunger cycle, transistor 402 turns OFF, and a previously applied indexing inhibit signal from the output of transistor 402 to input 334 of AND gate 338 is removed, an indexing is enabled.
If the operator, for some reason, does not remove the completely filled syringes and a filled syringe is inadvertently indexed to the filling station 110, photocell 188 will turn OFF, providing a high output from OR gate 328, turning transistor 358 ON. This provides a high potential signal at the base of transistor 368 which, through switch 354 and the following inhibit circuitry, causes transistor 380 to conduct applying a low potential input at 336 of AND" gate 338 precluding any subsequent indexing of the turret until an empty syringe is sensed at the filling station 110. it should be understood that switch 354 is located to sense the presence of a syringe barrel at station in the same manner as switch 308. Switch 354 is constructed so that contacts 356 are closed when the syringe is sensed at station 110 and contacts 357 are closed when no syringe is sensed at station 1 10.
A further feature in the control circuit, associated with the manual indexing function of manual index switch 320, is that upon closing of the manual index switch, a control is supplied to the anode of SCR 410 which drives the base of transistor 412 keeping the transistor 394 from conducting thereby precluding plunger operation.
We claim 1. A medicament filling device for a syringe of the type having a barrel member and a plunger, comprising: frame means, a syringe filling station on said frame means for supporting a syringe to be filled, means for filling the syringe barrel through the breech end thereof, means for inserting the plunger after filling, the plunger having a resilient portion, said plunger including means compressing the resilient portion, and means releasing the resilient portion after insertion of the plunger.
2. A medicament filling device for a syringe of the type having a barrel member and a plunger as defined in claim 1, wherein said means for inserting the plunger includes means for releasing the plunger prior to contact with the medicament in the syringe barrel.
3. A medicament filling device for a syringe of the type having a barrel member and a plunger as defined in claim 1, including a lower support for supporting the syringe barrel, an upper support for supporting the syringe plunger in spaced relation to the syringe barrel, and said means for inserting the plunger including a reciprocable toolhead assembly for forcing said plunger from the upper support.
4. A medicament filling device for a syringe of the type having a barrel member and a plunger as defined in claim 3, wherein the upper support includes a plurality of resilient fingers for releasably supporting the plunger.
5. A medicament filling device for a syringe of the type having a barrel member and a plunger, comprising: frame means, a syringe filling station on said frame means for supporting a syringe to be filled, means for filling the syringe barrel through the breech end thereof, means for inserting the plunger after filling, said syringe plunger being of the type having a piston plunger and a sleeve, means on said frame means for shifting said sleeve to activate the piston plunger so that the sleeve releases the piston into the syringe barrel.
6. A medicament filling device for syringes of the type having a barrel member and a plunger, comprising: frame means, a turret assembly on said frame means having a lower support for holding a plurality of syringe barrels, said turret assembly having an upper support for holding a plurality of syringe plungers above and in alignment with the syringe barrels, means on said frame means for filling said syringe barrels at a predetermined first station, means on said frame means for inserting said plungers into said barrels at a predetermined second station, said plungers having a resilient portion and means for compressing the resilient portion, and means for releasing the resilient portion after insertion of the plunger.
7. A medicament filling device for syringes of the type hav ing 1 barrel member and a plunger, comprising: frame means, a turret assembly on said frame means having a lower support for holding a plurality of syringe barrels, said turret assembly having an upper support for holding a plurality of syringe plungers above and in alignment with the syringe barrels, means on said frame means for filling said syringe barrels at a predetermined first station, means on said frame means for inserting said plungers into said barrels at a predetermined second station, said plungers each including a piston plunger of said sleeves and said piston plungers.
9. A medicament filling device for syringes of the type having a barrel member and a plunger as defined in claim 6. including means for shifting the turret assembly in a vertical direction.
I I i l

Claims (9)

1. A medicament filling device for a syringe of the type having a barrel member and a plunger, comprising: frame means, a syringe filling station on said frame means for supporting a syringe to be filled, means for filling the syringe barrel through the breech end thereof, means for inserting the plunger after filling, the plunger having a resilient portion, said plunger including means compressing the resilient portion, and means releasing the resilient portion after insertion of the plunger.
2. A medicament filling device for a syringe of the type having a barrel member and a plunger as defined in claim 1, wherein said means for inserting the plunger includes means for releasing the plunger prior to contact with the medicament in the syringe barrel.
3. A medicament filling device for a syringe of the type having a barrel member and a plunger as defined in claim 1, including a lower support for supporting the syringe barrel, an upper support for supporting the syringe plunger in spaced relation to the syringe barrel, and said means for inserting the plunger including a reciprocable toolhead assembly for forcing said plunger from the upper support.
4. A medicament filling device for a syringe of the type having a barrel member and a plunger as defined in claim 3, wherein the upper support includes a plurality of resilient fingers for releasably supporting the plunger.
5. A medicament filling device for a syringe of the type having a barrel member and a plunger, comprising: frame means, a syringe filling station on said frame means for supporting a syringe to be filled, means for filling the syringe barrel through the breech end thereof, means for inserting the plunger after filling, said syringe plunger being of the type having a piston plunger and a sleeve, means on said frame means for shifting said sleeve to activate the piston plunger so that the sleeve releases the piston into the syringe barrel.
6. A medicament filling device for syringes of the type having a barrel member and a plunger, comprising: frame means, a turret assembly on said frame means having a lower support for holding a plurality of syringe barrels, said turret assembly having an upper support for holding a plurality of syringe plungers above and in alignment with the syringe barrels, means on said frame means for filling said syringe barrels at a predetermined first station, means on said frame means for inserting said plungers into said barrels at a predetermined second station, said plungers having a resilient portion and means for compressing the resilient portion, and means for releasing the resilient portion after insertion of the plunger.
7. A medicament filling device for syringes of the type having 1 barrel member and a plunger, comprising: frame means, a turret assembly on said frame means having a lower support for holding a plurality of syringe barrels, said turret assembly having an upper support for holding a plurality of syringe plungers above and in alignment with the syringe barrels, means on said frame means for filling said syringe barrels at a predetermined first station, means on said frame means for inserting said plungers into said barrels at a predetermined second station, said plungers each including a piston plunger and a sleeve for holding the piston inactive, means on said frame means for shifting the plunger sleeves with respect to the piston plungers to activate the pistons.
8. A medicament filling device for syringes of the type having a barrel member and a plunger as defined in claim 7, wherein said means for shifting the sleeve means includes an arcuate cam assembly on said frame means receiving portions of said sleeves and said piston plungers.
9. A medicament filling device for syringes of the type having a barrel member and a plunger as defined in claim 6, including means for shifting the turret assembly in a vertical direction.
US26683A 1970-04-08 1970-04-08 Syringe filling apparatus Expired - Lifetime US3662517A (en)

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WO1998033705A1 (en) * 1997-02-05 1998-08-06 Smithkline Beecham Corporation System producing sterile liquid filled delivery devices
WO1998035624A1 (en) * 1997-02-05 1998-08-20 Smithkline Beecham Corporation Method and apparatus for automatically transferring liquids between containers
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US7392638B2 (en) 2000-08-10 2008-07-01 Baxa Corporation Method, system, and apparatus for handling, labeling, filling, and capping syringes with improved cap
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US6976349B2 (en) 2000-08-10 2005-12-20 Baxa Corporation Method for filling and capping syringes
US7631475B2 (en) 2000-08-10 2009-12-15 Baxa Corporation Method for filling and capping syringes
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US20060225381A1 (en) * 2000-08-10 2006-10-12 Baldwin Brian E Method, system, and apparatus for handling, labeling, filling and capping syringes
US7469518B2 (en) 2000-08-10 2008-12-30 Baxa Corporation Method for handling and labeling syringes
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US6915619B2 (en) 2001-08-10 2005-07-12 Baxa Corporation Method for handling syringe bodies
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US8601776B2 (en) 2004-05-20 2013-12-10 Knapp Logistics & Automation, Inc. Systems and methods of automated dispensing, prescription filling, and packaging
US8141330B2 (en) 2004-05-20 2012-03-27 KNAPP Logistics Automation, Inc. Systems and methods of automated tablet dispensing, prescription filling, and packaging
US9752185B2 (en) 2004-09-15 2017-09-05 Integenx Inc. Microfluidic devices
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US20070119121A1 (en) * 2005-11-28 2007-05-31 Pdc Facilities, Inc. Filling machine
US7882860B2 (en) * 2006-01-09 2011-02-08 Spitz Gregory A Syringe filling apparatus
US20090178726A1 (en) * 2006-01-09 2009-07-16 Spitz Gregory A Syringe filling apparatus
US7571747B2 (en) 2006-01-09 2009-08-11 Spitz Gregory A Syringe filling apparatus
US20070161959A1 (en) * 2006-01-09 2007-07-12 Spitz Gregory A Syringe filling apparatus
US20100162548A1 (en) * 2006-09-28 2010-07-01 Juergen Leidig Device and method for mounting a needle guard on a syringe body
US8234769B2 (en) * 2006-09-28 2012-08-07 Robert Bosch Gmbh Device and method for mounting a needle guard on a syringe body
US7913720B2 (en) * 2006-10-31 2011-03-29 Fht, Inc. Automated drug preparation apparatus including serial dilution functionality
US20080169045A1 (en) * 2006-10-31 2008-07-17 Forhealth Technologies, Inc. Automated drug preparation apparatus including serial dilution functionality
US9663819B2 (en) 2009-06-05 2017-05-30 Integenx Inc. Universal sample preparation system and use in an integrated analysis system
US9731266B2 (en) 2010-08-20 2017-08-15 Integenx Inc. Linear valve arrays
US20170042767A1 (en) * 2010-12-30 2017-02-16 Ge Healthcare Limited Needle holder for a vial
US8286671B1 (en) 2011-03-23 2012-10-16 Saverio Roberto Strangis Automated syringe filler and loading apparatus
US8807177B2 (en) * 2011-05-18 2014-08-19 Saverio Roberto Strangis Automated syringe filler and loading apparatus
US20120325365A1 (en) * 2011-05-18 2012-12-27 Saverio Roberto Strangis Automated syringe filler and loading apparatus
US20120325368A1 (en) * 2011-05-18 2012-12-27 Saverio Roberto Strangis Automated syringe filler and loading apparatus
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US10191071B2 (en) 2013-11-18 2019-01-29 IntegenX, Inc. Cartridges and instruments for sample analysis
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CN105873681A (en) * 2013-11-18 2016-08-17 尹特根埃克斯有限公司 Cartridges and instruments for sample analysis
US9828121B2 (en) * 2013-12-23 2017-11-28 Shenzhen China Star Optoelectronics Technology Co., Ltd Sealant filling device
US20160288934A1 (en) * 2013-12-23 2016-10-06 Shenzhen China Star Optoelectronics Technology Co., Ltd A sealant filling device
US10961561B2 (en) 2014-05-21 2021-03-30 IntegenX, Inc. Fluidic cartridge with valve mechanism
US10208332B2 (en) 2014-05-21 2019-02-19 Integenx Inc. Fluidic cartridge with valve mechanism
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CA940892A (en) 1974-01-29
GB1328421A (en) 1973-08-30
DE2117258A1 (en) 1971-10-21

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