Search Images Maps Play YouTube News Gmail Drive More »
Sign in
Screen reader users: click this link for accessible mode. Accessible mode has the same essential features but works better with your reader.


  1. Advanced Patent Search
Publication numberUS3630199 A
Publication typeGrant
Publication date28 Dec 1971
Filing date26 May 1970
Priority date26 May 1970
Publication numberUS 3630199 A, US 3630199A, US-A-3630199, US3630199 A, US3630199A
InventorsGangarosa Eugene J, Gangarosa Louis P, Mahan Parker E
Original AssigneeGangarosa Eugene J, Gangarosa Louis P, Mahan Parker E
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Unitized injection system
US 3630199 A
Abstract  available in
Previous page
Next page
Claims  available in
Description  (OCR text may contain errors)

United States Patent [72] Inventors Decatur, Ga. 30033 [21]- Appl. No. 40,663 [22] Filed May 26, 1970 [45] Patented Dec.28,l971

[54] UNITIZED INJECTION SYSTEM 6 Claims, 5 Drawing Figs.

[52] U.S.Cl l28/218M [51] lnt.Cl A61m 5/00 [50] Field of Search 128/218 R, 218 M, 218N,2l8 P,218 PA,218 D, 220, 215

[56] References Cited UNITED STATES PATENTS I 3,327,710 6/1967 Freeberg et a1 128/218 M 3,330,282 7/1967 Visser et al. 128/218 M X 3,397,694 8/1968 Ogle 3,489,147 1/1970 Shaw ABSTRACT: A disposable syringe including a barrel having one medicinal solution therein and a cannula extending therefrom, and a vial removably attached to the barrel and receiving the cannula for isolated storage of a second medicament. With the barrel and vial in assembled, storage position, the syringe cannula tip is imbedded in a plug fixedly attached to the bottom wall of the vial, thereby preventing intcrmixing of the substances. However, when the parts are manipulated to a mixing position the cannula tip is withdrawn from the plug and air is introduced into the vial, thereby permitting a quantitative mixing of the substances under favorable pressure conditions. After mixing the syringe is removed completely from the vial, used in the regular manner, and the entire system thrown away.

UNITIZED INJECTION SYSTEM BACKGROUND OF THE INVENTION A number of combination syringe 'and vial mixing containers have recently been developed to facilitate the dispensing of certain medication. Many of the newer medications, especially the antibiotics, have a longer storage life in dry form. Such devices take advantage of the longer life and comprise, generally, a syringe and a storage vial removably assembled thereto to provide separate storage compartments for two substances. See, for example, US. Pats. Nos; 3,327,710; 3,330,281; 3,330,282; 3,332,421; 3,336,924; 3,397,694; and 3,416,657. In operation the assembly is manipulated to bring the two substances together for mixing, whereupon the syringe is removed from the vial ready for use.

A number of problems associated with the earlier devices have arisen, however, one of which is involved with the problem of pressure. It is commonly known that in removing medications from a sealed vial by insertion of the cannula through a stopper in the neck thereof, a negative pressure created as the medication is being removed must be overcome. Procedures have been developed to overcome this con dition so that the medication can be accurately and easily removed. An opposite pressure condition (positive pressure) arises with regard to earlier devices developed for use as combination syringes and mixing containers. In such cases, a substance is generally introduced into a closed or sealed system for mixing, creating a condition of positive pressure which sometimes makes the device awkward to handle and mixing difficult.

An additional problem attendant to the use of earlier known devices relates to the means for maintaining separation of the substances until time for mixture and use. The separating means, in some instances, is no more than a plug or a ball valve that is interjected into and obstructs the passageway connecting the storage containers. In operation, the obstruction is dislodged in preparation for mixing the substances. Upon dislodgement, however, the plug or ball valve, whichever the case might be, remains within the vial and represents danger in the form of interference with the proper mixing or, more importantly, the proper dispensing of the solution by drifting into and obstructing the fluid flow path.

Finally, problems have arisen in connection with some of the earlier known devices which prevented satisfactory mixing and dispensing of the substances contained therein. For example, in some cases the syringe barrel itself was used as the container for mixing the substances before their being dispensed, and as such it was too small to accommodate suitable mixing without unreasonably long periods of agitation. Also, some of the earlier known devices were fabricated with small cavities that could sometimes entrap air, thereby introducing air bubbles into the loaded syringe. The cavities, additionally, were responsible for the prevention of complete expulsion of one substance out of its respective container and into the adjacent container, thereby preventing a quantitative mixture of the substances with the result being that an incomplete mixture of the substances and/or an incomplete quantity of was administered by the syringe.

SUMMARY OF THE INVENTION The present invention, on the other hand, includes a syringe containing a first medicament threadably received within the mouth of a mixing vial containing a second medicament, providing thereby separate containers for the storage of at least two ingredients which may be mixed immediately prior to use. During storage, a sealing means isolates one chamber from another and prevents inadvertent mixing by imbedding the tip of the syringe cannula into a rubber plug fixedly mounted in the bottom wall of the mixing vial. Possibility of the plugs obstructing the flow of the medicine subsequent to displacement of the cannula is therefore avoided. Removal of the cannula tip from the plug is accomplished by merely rotating the syringe one-half turn relative to the mixing vial. Upon such rotation the threaded connection between the syringe and the vial, causes a relative separation therebetween, therefore positioning the cannula within the vial with the tip thereof spaced from the plug allowing the complete expulsion of the solution contained in the syringe barrel through the cannula and into the mixing vial. After mixing with the second medicament in the vial, the mixture is aspirated into the syringe, the vial is removed and the syringe is ready for use.

To avoid the pressure problems previously described, resultant from performing the previous steps in a closed system, a venting means provides communication between the mixing vial and the atmosphere when the syringe is moved from the storage to the mixing position.

It is therefore an object of this invention to provide an improved unitized injection system utilizing a disposable combination syringe and mixing vial.

It is another object of the invention to provide a device of the type described wherein a first medicament is maintained separately from a second medicant during a storage period, then mixed immediately prior to use.

It is still another object of this invention to provide a device of the type described wherein complete mixing of the substances and complete expulsion of the mixture from the syringe is enhanced.

Some of the objects of the invention having been stated, other objects will appear as the description proceeds, when taken in connection with the accompanying drawings, in which:

FIG. I is a longitudinal view, partially in section, of a device employing the invention, the device being illustrated in position for storage;

FIG. 2 is a section view similar to FIG. 1, except illustrating the parts in position for mixing:

FIG. 3 is an enlarged sectional view, with parts broken away, of the cannula base in the position illustrated in FIG. 1;

FIG. 4 is an enlarged view of the cannula base similar to FIG. 3, except showing the parts in the mixing position illustrated in FIG. 2;

FIG. 5 is a longitudinal view, partially in section, illustrating the syringe shown in FIGS. 1 and 2 with the mixing vial removed.

Turning now to the drawings, and particularly to FIGS. 1 and 2, the unitized injection system, as contemplated by this invention, is referred to generally by the reference character 10 and comprises the combination of a syringe 20 and a mixing vial 30. Syringe 20 is threadably received within the mouth of vial 30 to selectively seal the contents of syringe 20 from that of vial 30, thus providing at least two separate storage compartments 29 and 39 for the separate storage of two or more substances until such time as their mixing and use is desired.

Syringe 20 preferably includes a tubular barrel 21 having an upper open end 22 which slidably receives a plunger 23, and a lower end 24 having an opening therein for the discharge of a solution through a cannula 25 extending therefrom. A boss 26, surrounding the base of cannula 25, protrudes from the outer surface of lower end 24, and provides a means for fixedly attaching an exteriorly threaded cannula base 27 thereto. It should be understood, however, that base 27 could be formed integral with the outside of lower end 24 of barrel 21.

Flanges l8 and 19 extend radially outward from barrel 21 adjacent the open end 22, thereby providing finger grips, adapted for use in cooperation with loop 17 on the exposed end of slidable plunger 23 to facilitate the manipulation of the parts during use.

Referring now to the combination storage and mixing vial 30, shown in FIGS. I and 2, the upper end or mouth 31 of vial 30 includes interior threads mating with and receiving the threaded base 27 of syringe 20. A top wall 32 having an opening or passageway 33 therein extends inwardly from the sidewalls of vial 30 at a point below the mouth 31 of vial 30 a distance approximately equaling the length of hub 27. Cannula 25 protrudes through the opening 33 into the interior 39 of mixing vial 30. A washer 34 is positioned atop wall 32, which in the position shown in FIG. 3, engages the free end of base 27 to seal the connection between syringe 20 and vial 30. A rubber plug 35 is fixedly received within a recess in the inner bottom wall 37 of vial 30 and aligned with the longitudinal dimension of cannula 25 so that when syringe 21 is threaciably attached to vial 30 (FIGS. 1 and 3) in the storage position, the point of cannula 25 is imbedded therein thus sealing the opening in cannula 25 and preventing intermixing of the substances in compartments 29 and 39.

The storage compartment 29 for solution X is defined by the bottom wall of plunger 23, barrel 21, and the hollow passageway of cannula 25, while the mixing compartment 39 in via! 30 is defined by wall 32 sealed by washer 34 and hub 27, vial wall 38, cannula 25, and plug 35. Substance X which is generally a solution and substance Y, which may be either a liquid or a powder soluble in substance X, can be stored in isolation in compartments 29 and 39 respectively, free from contamination from the air outside the syringe and from intermixing within.

Additionally, the wall 38 of vial 30 includes an air vent 36 therethrough at a point slightly above wall 32, so positioned as to clear hub 27, then in the retracted position shown in FIGS. 2 and 4 to provide communication between mixing compartment 39 and the atmosphere. Beads 11 and 12 or other similar indicating marks may be provided on the outer walls of syringe 20 and vial 30 and, in initial misaligned position, indicate hub 27 covers and seals air vent 36, while in aligned position with hub 27 in retracted position, indicate hub 27 has cleared and opened air vent 36.

All of the parts of the invention described herein, with the exception of plug 35, washer 34 and cannula 25, can be made from glass, plastic or other suitable material that is adapted to be sterilized easily. Plug 35 and washer 34 are made from materials that will not impart chemical or particulate contamination to the contents of compartments 29 and 39, such as a high-quality natural or synthetic rubber or a resilient plastic.

In operation, the use of this syringe is initiated by rotating syringe 20 relative to vial 30 so as to align marks 1] and 12 as illustrated in FIGS. 2 and 4. As a result the syringe 20 is partially separated from vial 30, hub 27 clears passageway 36, and the tip of cannula 25 is slightly withdrawn from plug 35. The plunger 23 is then urged into barrel 21, causing the solution X therein to be completely expelled into vial 30 causing mixture with substance Y. After mixing, plunger 23 is returned to its retracted position (FIG. 1) causing aspiration of the mixture back into syringe 20. Movement of hub 27 to a position clearing passageway 36 permits air to escape from vial 30 when solution X is being expelled into vial 30, as well as permitting air to enter vial 30 when the mixture is being aspirated therefrom, therefore, permitting the mixing and aspirating to be carried out under conditions of neutral pressure. Vial 30 is then unscrewed and completely removed from syringe 20 and either discarded or retained, if desired, to cover cannula 25 between uses of syringe 20. After removal of vial 30, syringe 20 is ready for use charged with a mixture XY (FIG. 5).

While the preceding description has disclosed a specific em bodiment of this invention in its preferred form, it is to be understood that various changes in details and arrangement may be made without departing from the spirit and scope of the invention.

We claim: 1

l. A unitized injection assembly comprising:

a. a vial having an open end defining a combination first storage and mixing compartment;

b. a hypodermic syringe including a second, storage compartment, a plunger reciprocable within said second compartment, and a cannula having a base, said base of the cannula including means for attaching said vial thereon with the cannula extending into the via; c. sealing means engageable with the free end of said cannula for isolating said first and second compartments from each other;

d. said vial being movable relative to said syringe between a first, storage position in which the open end of said vial is engaged with'the opposed, adjacent end of said syringe and the free end of said cannula is in engagement with said sealing means, thus forming a seal between said first and second compartments, and a second, mixing position with said open end of the vial spaced slightly from the opposed end of said syringe and the free end of said cannula withdrawn from said sealing means to permit communication between said first and second compartments; and

e. a venting means for allowing air to enter the vial in said second position.

2. The injection assembly according to claim I wherein said sealing means comprises a plug fixedly mounted on the bottom wall of the vial, said plug being in alignment with the longitudinal dimension of said cannula.

3. The injection assembly according to claim 1 wherein said venting means comprises a passageway through the sidewall of said vial at a point on a level with said cannula base, said base blocking said passageway in said first, storage position and clearing said passageway in said second, mixing position, whereby the vial is vented in the mixing position to facilitate mixing of the substances therein.

4. The injection assembly according to claim 3 wherein indicating means are provided on said vial and said syringe to indicate the position of said base relative to said passageway.

5. The injection assembly according to claim 1 wherein said attaching means comprises external threads on said cannula base and mating internal threads on the inner wall of said vial adjacent said open end.

6. The injection assembly according to claim I wherein a first medicament is provided in said first compartment, and a second medicament is provided in said second compartment, said first and second medicaments being isolated from each other in said first position, yet permitted to mix in said second position.

Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US3327710 *15 Nov 196327 Jun 1967Santo John DeCombination hypodermic syringe and mixing container
US3330282 *21 Aug 196411 Jul 1967Upjohn CoCombination syringe and vial mixing container
US3397694 *6 Jul 196520 Aug 1968C S M CorpCombination syringe package, syringe and chamber
US3489147 *22 Aug 196713 Jan 1970Shaw Joseph DenmanCombination mixing and injecting medical syringe
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US5281206 *19 Aug 199125 Jan 1994Icu Medical, Inc.Needle connector with rotatable collar
US5344414 *19 Feb 19936 Sep 1994Icu Medical Inc.Medical connector
US5688254 *7 Jun 199518 Nov 1997Icu Medical, Inc.Medical connector
US5776116 *7 Jun 19957 Jul 1998Icu Medical, Inc.Medical connector
US5810792 *3 Apr 199622 Sep 1998Icu Medical, Inc.Locking blunt cannula
US5954708 *8 Apr 199821 Sep 1999Icu Medical, Inc.Medical connector
US669581711 Jul 200024 Feb 2004Icu Medical, Inc.Medical valve with positive flow characteristics
US69163097 Aug 200312 Jul 2005Icu Medical, Inc.Medical valve with positive flow characteristics
US74978492 May 20063 Mar 2009Icu Medical, Inc.High flow rate needleless medical connector
US751684622 Jan 200414 Apr 2009Bernd HansenAmpoule
US76287742 May 20068 Dec 2009Icu Medical, Inc.Needleless Medical Connector
US770871428 Jan 20054 May 2010Baxter International Inc.Dialysis connector with retention and feedback features
US77132473 May 200611 May 2010Icu Medical, Inc.Medical valve and method of use
US77132483 May 200611 May 2010Icu Medical, Inc.Medical valve and method of use
US77132493 May 200611 May 2010Icu Medical, Inc.Medical valve and method of use
US77178833 May 200618 May 2010Icu Medical, Inc.Medical valve and method of use
US77178843 May 200618 May 2010Icu Medical, Inc.Medical valve and method of use
US77178853 May 200618 May 2010Icu Medical, Inc.Medical valve and method of use
US77178863 May 200618 May 2010Icu Medical, Inc.Medical valve and method of use
US77178873 May 200618 May 2010Icu Medical, Inc.Medical valve and method of use
US77225753 May 200625 May 2010Icu Medical, Inc.Medical valve and method of use
US77225763 May 200625 May 2010Icu Medical, Inc.Medical valve and method of use
US77631993 May 200627 Jul 2010Icu Medical, Inc.Method of making a seal having slit formed therein
US78243933 May 20062 Nov 2010Icu Medical, Inc.Medical connector having high flow rate characteristics
US80027653 May 200623 Aug 2011Icu Medical, Inc.Medical valve with fluid escape space
US810531425 Oct 200731 Jan 2012Icu Medical, Inc.Medical connector
US822139127 Jul 201017 Jul 2012Icu Medical, Inc.Needleless medical connector
US839860730 Jan 201219 Mar 2013Icu Medical, Inc.Medical connector
US844462816 Jul 201221 May 2013Icu Medical, Inc.Needleless medical connector
US845457923 Mar 20104 Jun 2013Icu Medical, Inc.Medical connector with automatic valves and volume regulator
US862851511 Mar 201314 Jan 2014Icu Medical, Inc.Medical connector
US875830612 May 201124 Jun 2014Icu Medical, Inc.Medical connectors and methods of use
US887085020 May 201328 Oct 2014Icu Medical, Inc.Medical connector
US91864942 May 201417 Nov 2015Icu Medical, Inc.Medical connector
US919275319 Jun 201424 Nov 2015Icu Medical, Inc.Medical connectors and methods of use
US920524321 Oct 20148 Dec 2015Icu Medical, Inc.Medical connectors and methods of use
US923812927 Oct 201419 Jan 2016Icu Medical, Inc.Medical connector
US92782064 Apr 20138 Mar 2016Icu Medical, Inc.Medical connectors and methods of use
US941520012 Nov 201516 Aug 2016Icu Medical, Inc.Medical connector
US944006020 Dec 201313 Sep 2016Icu Medical, Inc.Medical connectors and methods of use
US95331377 Jan 20143 Jan 2017Icu Medical, Inc.Medical connector
US955518021 Nov 200831 Jan 2017Baxter International Inc.Systems and methods for removing air from the patient's peritoneal cavity
US97509267 Dec 20155 Sep 2017Icu Medical, Inc.Medical connectors and methods of use
US20050197646 *28 Jan 20058 Sep 2005Brian ConnellDialysis connector with retention and feedback features
US20060163109 *22 Jan 200427 Jul 2006Bernd HansenAmpoule
US20060206058 *3 May 200614 Sep 2006Lopez George AMedical valve and method of use
US20060264891 *3 May 200623 Nov 2006Icu Medical, Inc.Medical valve and method of use
USD6447318 Oct 20106 Sep 2011Icu Medical, Inc.Medical connector
USD7864273 Dec 20149 May 2017Icu Medical, Inc.Fluid manifold
USD7935513 Dec 20141 Aug 2017Icu Medical, Inc.Fluid manifold
CN100431514C22 Jan 200412 Nov 2008贝尔恩德汉森Ampola
EP2441431A3 *5 Aug 20116 Nov 2013Henke-Sass, Wolf GmbHContainer for the production of a conditioned blood compound
WO2004091472A122 Jan 200428 Oct 2004Bernd HansenAmpoule
U.S. Classification604/82, 604/89
International ClassificationA61J1/00, A61J1/06, A61J1/20, A61J1/14
Cooperative ClassificationA61J1/065, A61J2001/2031, A61J1/2096, A61J1/2093, A61J2001/2075, A61J2001/201
European ClassificationA61J1/20F, A61J1/20D