|Publication number||US3598127 A|
|Publication date||10 Aug 1971|
|Filing date||6 Jun 1968|
|Priority date||6 Jun 1968|
|Publication number||US 3598127 A, US 3598127A, US-A-3598127, US3598127 A, US3598127A|
|Inventors||Wepsic James G|
|Original Assignee||Wepsic James G|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (6), Non-Patent Citations (2), Referenced by (118), Classifications (12)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent Inventor James G. Wersie Masachusetts General Hospital, Boston, Mas. 021 14 June 6, 1968 Aug. 10, 1971 Appl. No. Filed Patented CATHETER HAVING ANTIBACTERIAL SUBSTANCE THEREIN PROVIDED WITH MEANS PERMI'I'I'ING SLOW RELEASE OF SAID SUBSTANCE 6 Claims, 2 Drawing Fgs.
128/349, 128/260,424/l6, 424/21 Int. Cl ..A61m'25/00 Field of Search 128/348- 351, 325, 343, 214.4, 260, DIG. 21; 3/1; 138/118,137,I38;424/16,1923;239/36,145
References Cited UNITED STATES PATENTS 4/1941 Flynn 8/1960 Brown 138/118 ll9/l4.47
3,279,996 10/1966 Long et al 424/19 3,365,728 l/1968 Edwards et al. 3/1 3,434,869 3/1969 Davidson 128/349 X FOREIGN PATENTS I 701,813 9/1967 Belgium 128/349 OTHER REFERENCES Dow Corning Bulletin Vol. 10, No. 1 January, 1968 pg. 1 l28/Silicone DIG.
Dow Corning Bulletin Vol. 8, No. 1, January 1966, pg. 1 l28/Silicone DIG.
Primary Examiner-Dalton L. Truluck Attorney-Charles l-lieken ABSTRACT: A catheter has an inner tube of nonpermeable rubber formed with V-shaped grooves extending along its length on the outside carrying antibacterial agents permeable through polysiloxane rubber that surrounds the V-shaped grooves. The antibacterial agents are permeable through the polysiloxane rubber. Upon difi'usion through the polysiloxane layer the antibacterial agents help prevent infection caused by bacteria moving up the tube toward the bladder or other organ into which the catheter tube leads.
PATENTEB AUG] 0 I971 FIG.I
INVENTOR JAMES G. WEPSIC BY QWWQM AT TO R N E Y5 CATHETER HAVING ANTIBACTERIAL SUBSTANCE THEREIN PROVIDED WITH MEANS PERMITTING SLOW RELEASE OF SAID SUBSTANCE BACKGROUND OF THE INVENTION The present invention relates in general to catheters and more particularly concerns a novel catheter for reducing chance of infection developing in an organ, such as the bladder, to which a catheter tube leads from the outside of a patient.
It is known that bacterial count increases where a catheter enters the body. Thus, the presence of a catheter, often essential during the treatment of patients with certain conditions, increases the chances of the patient developing an internal infection. One possible approach toward reducing the chances of infection is to continuously have an attendant sponge the area where the catheter enters the body with an antibacterial agent. The shortage of personnel in hospitals makes this approach impractical.
Accordingly, it is an important object of this invention to reduce the chance of bacteria entering the body where a catheter is inserted.
It is another object of the invention to achieve the preceding object with a technique that requires negligible attention.
It is another object of the invention to achieve the preceding object over relatively long periods oftime.
It is another object of the invention to achieve the preceding objects with a structure that is relatively easy and inexpensive to fabricate and does not appreciably increase the outside diameter of the catheter.
SUMMARY OF THE INVENTION According to the invention, first means defines a hollow tube made of material that is impenneable to bacterial agents, such as rubber surrounded by means defining an outer layer of material permeable to an antibacterial agent between the first and second means. Typically, the second material is polysiloxane rubber. Typical antibacterial substances suitable for use include neomycin, bacitracin, sulfa, mandelamine, zepheran, hexachloraphine, and furadantoin.
Other features, objects and advantages of the invention will become apparent from the following specification when read in connection with the accompanying drawing in which:
BRIEF DESCRIPTION OF THE DRAWING FIG. 1 is a side view of a portion of a catheter according to the invention with the outer layer in section; and
FIG. 2 is a sectional view through section 2-2 of FIG. 1.
DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS With reference now to the drawing and more particularly FIGS. 1 and 2 thereofa catheter tube according to the invention comprises an inner layer of nonpermeable rubber II that defines a hollow fluid passage 12 through which fluids may be withdrawn from the patient. Inner rubber tube 11 may be formed with a number of V-shaped grooves 13-18, each filled with an antibacterial substance having the property that the permeability of the substance through polysiloxane rubber is much greater than through the nonpermeable rubber of inner tube 11. Examples of such antibacterial substances are neomycin, bacitracin, sulfa, mandelamine, zepheran, hexachloraphine, and furadantoin. The antibacterial substance in the V-shaped grooves is then sealed by an outer tube 2] of polysiloxane rubber sold under the trade name Silastic.
The following tests have been conducted: First, to demonstrate that antibacterial agents will go through layer 2] of polysiloxane rubber, Silastic capsules constructed of hollow Silastic tubing were sealed at each end to enclose the aboveidentified antibacterial substances inside respective ones of the capsules while control capsules were not filled with antibacterial substances. The filled capsules along with the control capsules were placed in separate tubes of saline. After a 7- day equilibration, small samples of the fluid were placed on pieces of filter paper. These pieces were then placed on bloodagar culture plates which previously has been inoculated with bacteria (bacteria obtained from urine of patients with infections). No inhibition of bacterial growth occurred a round the control discs while a zone of inhibition appeared around the neomycin disc. These tests demonstrate that antibacterial agent passed through the Silastic membrane of the capsule in concentrations great enough inhibit bacterial growth. Thus, apart from its utility as a catheter, the invention has independent utility for slowly dispensing antibacterial substance into a region adjacent the outside of the Silastic tubing to inhibit the growth of bacteria.
The second experiment was similar to the first except that thin slices of the wall of the capsules were placed on the bacteria-inoculated plates. Similar inhibition occurred indicating that the Silastic membrane was able to hold the drug, much like a sponge holds water, and then diffuse it from its surface.
There has been described a novel antibacterial substance dispenser, in one form a catheter for reducing infection and/or inhibiting bacteria growth over a long period of time without attention at relatively low cost with a simple structure that negligibly, if at all, increases the diameter of the catheter tube when embodied in that form. It is evident that those skilled in the art may now make numerous uses and modifications of and departures from the specific embodiments described herein without departing from the inventive concepts. For example, the V-shaped grooves could be omitted and the catheter comprise a nonpermeable rubber inner tube surrounded by a Silastic outer tube that is permeated with antibacterial agent introduced by soaking such a tube in an antibacterial substance until the Silastic outer tube absorbs enough substance to provide the desired degree of bacterial inhibition over the desired length of time. Other antibacterial substances and tube materials may be employed so long as the relationship between the antibacterial substance, inner tube and outer tube is such that the inner tube is substantially nonpermeable to the antibacterial substance and the outer tube is substantially permeable to the antibacterial substance. Therefore, invention is to be construed as embracing each and every novel feature and novel combination of features present in or possessed by the apparatus and techniques herein disclosed and limited solely by the spirit and scope of the appended claims.
What I claim is:
I. A catheter containing an antibacterial substance for insertion into the body comprising an elongate outer hollow tube permeable to an antibacterial substance for slowly dispensing said antibacterial substance therethrough after insertion into the body,
an elongate inner tube coextensive with and concentric within said outer tube immediately adjacent thereto and made of material substantially nonpermeable to said antibacterial substance,
and means containing said antibacterial substance positioned on the outside of said inner tube immediately adjacent to the inside of said outer tube.
2. A catheter tube in accordance with claim I wherein said outer tube is made of polysiloxane rubber.
3. A catheter tube in accordance with claim 2 wherein said antibacterial substance comprises a substance in the group comprising neomycin, bacitracin, sulfa, mandelamine, zepheran, hexachloraphine, and furadantoin.
4. A catheter tube in accordance with claim I wherein said outer tube is made of polysiloxane rubber and said inner tube is made of rubber nonpermeable to said antibacterial sub stance.
5. A catheter tube in accordance with claim I wherein said means containing said antibacterial substance comprises at least one longitudinal groove formed in said inner tube immediately adjacent to said outer tube,
antibacterial substance comprises a subst n f rbrn he grnup comprising neomycin, bacitracin, sulfa, zepheran, hexachloraphine, and furadantoin.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US2237220 *||29 Sep 1938||1 Apr 1941||Wardlyn Corp||Application of cellulose derivatives|
|US2947282 *||6 Aug 1958||2 Aug 1960||Brown Co D S||Microbicidal elastomer articles|
|US3279996 *||28 Aug 1962||18 Oct 1966||Folkman Moses Judah||Polysiloxane carrier for controlled release of drugs and other agents|
|US3365728 *||18 Dec 1964||30 Jan 1968||Edwards Lab Inc||Upholstered heart valve having a sealing ring adapted for dispensing medicaments|
|US3434869 *||2 Nov 1964||25 Mar 1969||Dow Corning||Foley catheter with silicone rubber coating|
|BE701813A *||Title not available|
|1||*||Dow Corning Bulletin Vol. 10, No. 1 January, 1968 pg. 1 128/Silicone DIG.|
|2||*||Dow Corning Bulletin Vol. 8, No. 1, January 1966, pg. 1 128/Silicone DIG.|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3797478 *||11 Jul 1972||19 Mar 1974||M Walsh||Multi-functional valve for use in the urethra|
|US3877461 *||2 Jul 1973||15 Apr 1975||Investors In Ventures Inc||Device for controlling body fluids|
|US3946727 *||11 Jul 1972||30 Mar 1976||Olympus Optical Co., Ltd.||Flexible tube assembly for an endoscope|
|US4054139 *||20 Nov 1975||18 Oct 1977||Crossley Kent B||Oligodynamic catheter|
|US4343788 *||29 Jun 1979||10 Aug 1982||The Procter & Gamble Company||Antimicrobial polymer compositions|
|US4381380 *||3 Nov 1980||26 Apr 1983||Leveen Harry H||Thermoplastic polyurethane article treated with iodine for antibacterial use|
|US4392848 *||25 Jun 1979||12 Jul 1983||The Procter & Gamble Company||Catheterization|
|US4432766 *||29 Jul 1981||21 Feb 1984||Baxter Travenol Laboratories, Inc.||Conduit connectors having antiseptic application means|
|US4460367 *||12 Jul 1982||17 Jul 1984||Alza Corporation||Device containing biocide producing paraformalde and an acid|
|US4479795 *||27 Jul 1982||30 Oct 1984||The Procter & Gamble Company||Antimicrobial polymer compositions|
|US4542169 *||12 Dec 1983||17 Sep 1985||Rohm And Haas Company||Biomedical devices containing isothiazolones to control bacteria growth|
|US4564364 *||26 May 1983||14 Jan 1986||Alza Corporation||Active agent dispenser|
|US4603152 *||1 Oct 1984||29 Jul 1986||Baxter Travenol Laboratories, Inc.||Antimicrobial compositions|
|US4623329 *||15 Dec 1983||18 Nov 1986||The Procter & Gamble Company||Drainage and infusion catheters having a capillary sleeve forming a reservoir for a fluid antimicrobial agent|
|US4668221 *||22 Jun 1985||26 May 1987||Luther Medical Products, Inc.||Assembly of stylet and catheter|
|US4677143 *||27 Nov 1985||30 Jun 1987||Baxter Travenol Laboratories, Inc.||Antimicrobial compositions|
|US4710181 *||10 Jun 1986||1 Dec 1987||Genus Catheter Technologies, Inc.||Variable diameter catheter|
|US4717379 *||1 Jul 1985||5 Jan 1988||Mediplast Ab||Catheter, probe or similar device|
|US4723950 *||20 Feb 1987||9 Feb 1988||C. R. Bard, Inc.||Urine drainage bag outlet with barrier against microbial infection|
|US4738666 *||28 Jan 1987||19 Apr 1988||Genus Catheter Technologies, Inc.||Variable diameter catheter|
|US4950232 *||11 Jul 1988||21 Aug 1990||Surelab Superior Research Laboratories||Cerebrospinal fluid shunt system|
|US5007897 *||30 May 1989||16 Apr 1991||Kalb Irvin M||Drug delivery catheter|
|US5019378 *||18 Aug 1989||28 May 1991||Cuno, Incorporated||Elastomeric composition containing therapeutic agents and articles manufactured therefrom|
|US5019601 *||18 Aug 1989||28 May 1991||Cuno, Incorporated||Elastomeric composition containing therapeutic agents and articles manufactured therefrom|
|US5059186 *||23 Mar 1989||22 Oct 1991||Vitaphore Corporation||Percutaneous access device|
|US5100383 *||24 Jul 1990||31 Mar 1992||Meir Lichtenstein||Catheters permitting controlled diffusion|
|US5135502 *||13 Mar 1990||4 Aug 1992||Medfusion Inc.||Solid introducer for catheter to a port and method of use|
|US5248301 *||27 Nov 1989||28 Sep 1993||Medfusion, Inc.||Transcutaneous infusion apparatus and methods of manufacture and use|
|US5261896 *||13 Dec 1991||16 Nov 1993||Rochester Medical Corporation||Sustained release bactericidal cannula|
|US5269770 *||13 Mar 1992||14 Dec 1993||Rochester Medical Corporation||Microcidal agent releasing catheter with balloon|
|US5300059 *||19 Nov 1991||5 Apr 1994||Hydro Slip Technologies Inc.||Bloodbag and method of making same|
|US5344411 *||3 Nov 1993||6 Sep 1994||Leonard Bloom||Method and device for inhibiting HIV, hepatitis B and other viruses and germs when using a catheter in a medical environment|
|US5360402 *||29 Jan 1992||1 Nov 1994||Rochester Medical Corporation||Hand-actuated retention catheter|
|US5395651 *||10 Jun 1992||7 Mar 1995||Ad Tech Holdings Limited||Deposition of silver layer on nonconducting substrate|
|US5451215 *||13 Jan 1995||19 Sep 1995||Wolter; Dietmar||Suction drain for the aspiration of discharges|
|US5482740 *||8 Nov 1993||9 Jan 1996||Rochester Medical Corporation||Sustained release bactericidal cannula|
|US5492763 *||10 Feb 1994||20 Feb 1996||Spire Corporation||Infection resistant medical devices and process|
|US5501669 *||30 Mar 1995||26 Mar 1996||Rochester Medical Corporation||Urinary catheter with reservoir shroud|
|US5593718 *||2 Aug 1994||14 Jan 1997||Rochester Medical Corporation||Method of making catheter|
|US5599321 *||7 Jun 1995||4 Feb 1997||Rochester Medical Corporation||Sustained release bactericidal cannula|
|US5670111 *||2 Aug 1994||23 Sep 1997||Rochester Medical Corporation||Method of shaping structures with an overcoat layer including female urinary catheter|
|US5683370 *||21 Nov 1996||4 Nov 1997||Luther Medical Products, Inc.||Hard tip over-the-needle catheter and method of manufacturing the same|
|US5747178 *||6 Mar 1995||5 May 1998||Adtech Holding||Deposition of silver layer on nonconducting substrate|
|US5762638 *||14 Feb 1996||9 Jun 1998||Shikani; Alain H.||Anti-infective and anti-inflammatory releasing systems for medical devices|
|US5779687 *||16 Feb 1996||14 Jul 1998||Smiths Industries Public Limited Company||Method of removing undesirable fluid from respiration passages by suction catheter assemblies|
|US5820607 *||5 Jun 1995||13 Oct 1998||Board Of Regents, University Of Texas Systems||Multipurpose anti-microbial silastic sheath system for the prevention of device-related infections|
|US5902283 *||26 Mar 1997||11 May 1999||Baylor College Of Medicine Board Of Regents||Antimicrobial impregnated catheters and other medical implants|
|US5911702 *||6 Nov 1997||15 Jun 1999||Heartport, Inc.||Methods and devices for cannulating a patient's blood vessel|
|US5913848 *||6 Jun 1996||22 Jun 1999||Luther Medical Products, Inc.||Hard tip over-the-needle catheter and method of manufacturing the same|
|US5916208 *||21 Nov 1996||29 Jun 1999||Luther Medical Products, Inc.||Hard tip over-the-needle catheter and method of manufacturing the same|
|US5957893 *||8 Sep 1998||28 Sep 1999||Becton Dickinson & Co.||Hard tip over-the needle catheter and method of manufacturing the same|
|US5971954 *||29 Jan 1997||26 Oct 1999||Rochester Medical Corporation||Method of making catheter|
|US6059816 *||6 Mar 1998||9 May 2000||Moenning; Stephen P.||Apparatus and method for protecting a port site opening in the wall of a body cavity utilizing a sealing member and a biologically active compound|
|US6224983||13 Aug 1999||1 May 2001||Ad Tech Holdings Limited||Deposition of silver layer on nonconducting substrate|
|US6242042||14 Sep 1998||5 Jun 2001||Lrc Products Ltd.||Aqueous coating composition and method|
|US6290685||18 Jun 1998||18 Sep 2001||3M Innovative Properties Company||Microchanneled active fluid transport devices|
|US6302873||23 Feb 2000||16 Oct 2001||Stephen P. Moenning||Minimally invasive medical apparatus for dispensing a biologically active compound and an associated medical procedure for dispensing a biologically active compound|
|US6383434||30 Jun 1999||7 May 2002||Rochester Medical Corporation||Method of shaping structures with an overcoat layer including female urinary catheter|
|US6579539||22 Dec 1999||17 Jun 2003||C. R. Bard, Inc.||Dual mode antimicrobial compositions|
|US6596401||10 May 2000||22 Jul 2003||C. R. Bard Inc.||Silane copolymer compositions containing active agents|
|US6626888||26 Sep 1995||30 Sep 2003||Rochester Medical Corporation||Method of shaping structures with an overcoat layer including female urinary catheter|
|US6638259 *||28 Oct 1999||28 Oct 2003||Scimed Life Systems, Inc.||Biocompatible medical devices|
|US6663606 *||14 Feb 2000||16 Dec 2003||Scimed Life Systems, Inc.||Biocompatible medical devices|
|US6695815||21 Aug 2001||24 Feb 2004||Stephen P. Moenning||Minimally invasive medical apparatus for dispensing a biologically active compound and an associated medical procedure for dispensing a biologically active compound|
|US6706313||14 Sep 1999||16 Mar 2004||Lrc Products Ltd.||Aqueous coating composition and method|
|US6716200 *||18 Jan 2002||6 Apr 2004||C.R. Bard, Inc.||Antimicrobial urine collection system and methods of manufacturing the same|
|US6716895||15 Dec 1999||6 Apr 2004||C.R. Bard, Inc.||Polymer compositions containing colloids of silver salts|
|US6783513||29 May 2002||31 Aug 2004||Stephen P. Moenning||Body cavity access assembly and an associated medical procedure for dispensing a liquid|
|US7179849||26 Aug 2003||20 Feb 2007||C. R. Bard, Inc.||Antimicrobial compositions containing colloids of oligodynamic metals|
|US7820284||3 Dec 2002||26 Oct 2010||C.R. Bard Inc.||Microbe-resistant medical device, microbe-resistant polymeric coating and methods for producing same|
|US8034454||10 Aug 2009||11 Oct 2011||C.R. Bard, Inc.||Antimicrobial compositions containing colloids of oligodynamic metals|
|US8317873||23 Feb 2010||27 Nov 2012||The Ohio Willow Wood Company||Polymeric prosthetic liner with controlled stretch characteristics|
|US8523823||4 Dec 2009||3 Sep 2013||Ishay Ostfeld||Indwelling device|
|US8523951||22 Dec 2008||3 Sep 2013||The Ohio Willow Wood Company||Prosthetic socket interface and assembly|
|US8657792 *||27 Dec 2011||25 Feb 2014||Kathy Hintze||Medicinal tube lubricating system and associated use thereof|
|US8740833||18 Jul 2011||3 Jun 2014||Medtronic, Inc.||Anti-thrombogenic venous shunt method|
|US8808272||12 Jun 2006||19 Aug 2014||Boston Scientific Scimed, Inc.||Biocompatible medical devices|
|US8864730||12 Apr 2005||21 Oct 2014||Rochester Medical Corporation||Silicone rubber male external catheter with absorbent and adhesive|
|US9248058||7 Oct 2014||2 Feb 2016||Rochester Medical Corporation, a subsidiary of C.R. Bard, Inc.||Male external catheter with absorbent and adhesive|
|US20040047911 *||13 Aug 2003||11 Mar 2004||Medtronic, Inc.||Active agent delivery system including a poly(ethylene-co-(meth)Acrylate), medical device, and method|
|US20040068241 *||8 Apr 2003||8 Apr 2004||Fischer Frank J.||Implantable medical device|
|US20040086569 *||13 Aug 2003||6 May 2004||Medtronic, Inc.||Active agent delivery systems, medical devices, and methods|
|US20040111052 *||3 Dec 2003||10 Jun 2004||Moenning Stephen P.||Minimally invasive medical apparatus for dispensing a biologically active compound and an associated medical procedure for dispensing a biologically active compound|
|US20040115273 *||13 Aug 2003||17 Jun 2004||Medtronic, Inc.||Active agent delivery system including a hydrophobic cellulose derivative, medical device, and method|
|US20040116551 *||26 Aug 2003||17 Jun 2004||Terry Richard N.||Antimicrobial compositions containing colloids of oligodynamic metals|
|US20040126280 *||31 Dec 2002||1 Jul 2004||Leaman Donald H.||Method and apparatus for preserving urine specimens at room temperature|
|US20040127978 *||13 Aug 2003||1 Jul 2004||Medtronic, Inc.||Active agent delivery system including a hydrophilic polymer, medical device, and method|
|US20040167473 *||25 Feb 2004||26 Aug 2004||Moenning Stephen P.||Trocar-cannula complex, cannula and method for delivering fluids during minimally invasive surgery|
|US20050064038 *||11 Aug 2004||24 Mar 2005||Dinh Thomas Q.||Active agent delivery systems including a single layer of a miscible polymer blend, medical devices, and methods|
|US20050085775 *||12 Aug 2004||21 Apr 2005||Ishay Ostfeld||Indwelling device|
|US20050100580 *||14 Oct 2004||12 May 2005||Cook Incorporated||Hydrophilic coated medical device|
|US20050119613 *||8 Dec 2004||2 Jun 2005||Moenning Stephen P.||Fluid delivery trocar-cannula complex, fluid delivery accessory, and method for delivering fluids during minimally invasive surgery|
|US20050124571 *||15 Oct 2004||9 Jun 2005||Wendy Naimark||Microparticle protection of therapeutic agents|
|US20050175669 *||10 Mar 2005||11 Aug 2005||Oscar Jimenez||Highly lubricious hydrophilic coating utilizing dendrimers|
|US20050288630 *||29 Jun 2005||29 Dec 2005||Conway Anthony J||Cuff resistant foley catheter|
|US20060024838 *||6 Sep 2005||2 Feb 2006||Stockwell Scientific, Inc.||Method and apparatus for preserving urine specimens at room temperature|
|US20060025749 *||29 Sep 2005||2 Feb 2006||Moenning Stephen P||Trocar-cannula complex, cannula and method for delivering fluids during minimally invasive surgery|
|US20070073248 *||16 Aug 2006||29 Mar 2007||Rxtrocar, Ltd.||Trocar-cannula complex, cannula and method for delivering biologically active agents during minimally invasive surgery|
|US20070197980 *||12 Jun 2006||23 Aug 2007||James Barry||Biocompatible medical devices|
|US20080172011 *||29 Sep 2006||17 Jul 2008||Tyco Healthcare Group Lp||Catheters including antimicrobial sleeve and methods of making catheters|
|US20090293882 *||3 Dec 2009||C.R. Bard, Inc.||Antimicrobial compositions containing colloids of oligodynamic metals|
|US20100042039 *||28 Oct 2009||18 Feb 2010||Medtronic, Inc.||Cerebrospinal fluid shunt having long term anti-occlusion agent delivery|
|US20100298754 *||4 Dec 2009||25 Nov 2010||Ishay Ostfeld||Indwelling device|
|US20110208321 *||23 Feb 2010||25 Aug 2011||The Ohio Willow Wood Company||Polymeric Prosthetic Liner With Controlled Stretch Characteristics|
|DE10002434A1 *||22 Jan 2000||26 Jul 2001||Gerhard Stuebner||Catheter for removal of liquids from hollow organs of the body and for introduction of liquids comprises at least one section which is permeable for chosen liquids|
|EP0022289A1 *||23 Jun 1980||14 Jan 1981||THE PROCTER & GAMBLE COMPANY||Antimicrobial polymer compositions and use thereof in medical devices|
|EP0145505A2 *||14 Dec 1984||19 Jun 1985||THE PROCTER & GAMBLE COMPANY||Drainage and infusion catheters having a capillary sleeve forming a reservoir for a fluid antimicrobial agent|
|EP0372088A1 *||2 Jun 1989||13 Jun 1990||Sumitomo Electric Industries, Ltd.||Balloon for catheter|
|EP0476503A1 *||11 Sep 1991||25 Mar 1992||Dietmar Prof. Dr. Wolter||Suction drainage device for secretions suction|
|EP1015051A1 *||5 Jun 1996||5 Jul 2000||Board Of Regents The University Of Texas System||A multipurpose anti-microbial silastic sheath system for the prevention of device-related infections|
|WO1984001102A1 *||12 Sep 1983||29 Mar 1984||Hydromer Inc||Anti-bacterial medical material and device|
|WO1984004036A1 *||13 Feb 1984||25 Oct 1984||Baxter Travenol Lab||Articles and compositions providing antimicrobial effect during urinary drainage|
|WO1986002006A1 *||19 Sep 1985||10 Apr 1986||Baxter Travenol Lab||Antimicrobial compositions|
|WO1986007267A1 *||9 Jun 1986||18 Dec 1986||Genus Catheter Technologies||Variable diameter catheter|
|WO1987006846A1 *||8 May 1987||19 Nov 1987||Meir Lichtenstein||Improvements in or relating to bio-compatible non-thrombogenic surfaces|
|WO1989005671A1 *||22 Dec 1988||29 Jun 1989||Bard Ltd||Catheter|
|WO2003061732A2 *||13 Jan 2003||31 Jul 2003||Bard Inc C R||Antimicrobial urine collection system and methods of manufacturing the same|
|WO2004052440A1 *||11 Dec 2003||24 Jun 2004||Coloplast As||A urinary catheter device with a pharmaceutically active composition|
|U.S. Classification||604/265, 424/422|
|International Classification||A61L29/00, A61M25/16, A61M25/00, A61L29/16|
|Cooperative Classification||A61M25/00, A61L29/16, A61M2025/0056, A61L2300/404|
|European Classification||A61L29/16, A61M25/00|