|Publication number||US3589363 A|
|Publication date||29 Jun 1971|
|Filing date||25 Jul 1967|
|Priority date||25 Jul 1967|
|Also published as||CA947174A, CA947174A1, DE1616003B1|
|Publication number||US 3589363 A, US 3589363A, US-A-3589363, US3589363 A, US3589363A|
|Inventors||Anton Banko, Charles D Kelman|
|Original Assignee||Cavitron Corp|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (9), Referenced by (608), Classifications (18), Legal Events (4)|
|External Links: USPTO, USPTO Assignment, Espacenet|
United States Patent Anton Banko lnventors Brooklyn; Charles D. Kelman, New York, both of. N.Y. Appl. No. 655,790 Filed July 25, 1967 Patented June 29, 1971 Assignee Cavitron Corporation Long Island City, N.Y.
MATERIAL REMOVAL APPARATUS AND METHOD EMPLOYING HIGH FREQUENCY VIBRATIONS 16 Claims, 15 Drawing Figs.
OSCILLATOR B COOLANT SUPPLY A II P FRIED WATER FOREIGN PATENTS 1,429,637 1/1966 France. 790.277 2/1958 Great Britain 415,949 1/1967 Switzerland Primary Examiner-L. W. Trapp AltorneyEdwin C. Pearson ABSTRACT: An instrument for breaking apart and removal of unwanted material, especially suitable for surgical operations such cataract removal, including a handheld instrument having an operative tip vibrating at a frequency in the ultrasonic range with an amplitude controllable up to several thousandths of an inch. The operative tip is itself hollow and is in turn surrounded by a tubular sleeve to form an annular passage. The handpiece includes transducer means for converting a high frequency alternating current into mechanical vibrations and an impedance transformer for coupling these vibrations to the operative tips. Connections are also provided on the handpiece to a source of treatment fluid and a pump. The treatment fluid may be coupled to either the hollow interior of the tool or the surrounding annular passage, while the pump is coupled to the other. During use, the vibration of the operative tip against the tissue to be removed causes the latter to break apart into small particles which are then dispersed in the fluid flowing over the operative region. Concurrently, the pump withdraws the suspension of the tissue particles in the fluid from the operative site. The fluid flow must be regulated so as to control the pressure within limits at the operative site. The instrument is thus suitable for removing tissue from an enclosed area whereby the opening to permit access to the tissue to be removed need only be large enough to admit the tip of the operative tool.
TREATMENT FLUID SUPPLY PATENTEDJUNEQIQYI 3,589,363
OSCILLATOR a AT N COOLANT SUPPLY l? PUMP F D p AMP FR'EQ WATER I INVENTORS. ANTON BANKO CHARLES D. KELM their ATTORNEYS PATENTED JUH29 19m SHEET 2 [IF 2 their ATTORNEYS.
MATERllAL REMOVAL APPARATUS AND METHOD EMPLOYHNG HTGH FREQUENCY VIBRATIONS The present invention relates to material removal devices and methods, and more particularly to an instrument having a working operative tip vibrating at high frequencies and with minute amplitudes for breaking apart and removing material from relatively inaccessible places and techniques for its use. Although by no means limited thereto, the present apparatus is of particular advantage when employed as a surgical instrument for breaking apart and the removal of unwanted tissue.
Vibratory assemblies for the cutting of material have been in use for some time in a wide number of applications. One form of such apparatus employs a slurry formed of particles of abrasive material in a liquid medium in conjunction with an ultrasonically vibrating tool, whereby the vibratory energy imparted to the abrasive particles in the slurry hurl them against the surface to be cut with tremendous accelerations, thereby literally chipping away the material. This technique has been applied with great success to a wide variety of uses, particularly with respect to industrial machine tools.
However, this type of ultrasonic vibratory assembly is ineffective when applied to yielding materials and furthermore, requires a fairly open site whereby the interposition of the slurry between the vibrating tool tip and the work surface can be maintained at all times during the procedure. Moreover, separate means are required for the collection and removal of the spent slurry and debris, and the workpiece generally requires a flushing or washing to clean up the residual abrasive particles tending to adhere to it. U.S. Pats. Nos. 3,075,288, 3,076,904 and 3,213,537 involve high frequency vibratory instruments for particular use in the dental field. The instruments described in these patents do not necessarily require a source of abrasive particles, as described above in respect to industrial equipment. Also, these dental instruments do not have any means for removal of the particles created as a result of the high frequency vibrations, hence would be entirely inapplicable for use in inaccessible places.
The instrument described herein thus lends itself to the performance of delicate surgical procedures in extremely limited areas. One such surgical procedure, for which the instrument has proven especially effective, is the removal of cataracts from the eye. A cataract Operation requires total removal of the clouded lens which is usually accomplished by a 180 incision in the cornea, which is then lifted up to remove the clouded lens in one piece. The inventive instrument of this application obviates the need for such an incision requiring only one incision in the form ofa small aperture to allow the opera tive end of the instrument to be inserted within the eye.
The primary object of the present invention is to provide a vibratory instrument and method which are effective to break apart and remove soft, yielding material without the use of an auxiliary cutting medium and which is particularly adapted for use in restricted, enclosed sites, such as are encountered in surgical procedures.
it is a further object of the present invention to provide a vibratory instrument including a portion readily held and controlled by the human hand which is particularly adapted for use in surgical procedures.
Still another object of the present invention is to provide an instrument including a handpiece having an operative tip capable of vibrating at ultrasonic frequencies with minute amplitudes and having both a source of fluid and a pumping line adjacent its working end, whereby particles of the material to be removed are dispersed within the fluid and withdrawn from the operative site through the pumping line as they are produced so that further cleaning is unnecessary.
Another object of the present invention is to provide suitable power and fluid supplies and pumping means for use with such a handpiece, together with switch means for their control.
A further object of the present invention is to provide various operative tip configurations for use with such a handpiece whereby removal of materials from relatively inaccessible locations is facilitated.
Briefly, the present invention comprises an apparatus having a casing in which is mounted a vibratory assembly for converting electrical energy into high frequency mechanical vibrations which are used to break apart the unwanted tissue. Within said casing there is also a first passage for carrying a treatment fluid to the region where the vibrations are applied and a second passage for carrying a suspension of unwanted material in said treatment fluid away from said region which constitutes the above-mentioned inaccessible place. The apparatus also includes a means for supplying electrical energy to said vibratory assembly for the energization thereof and a means for supplying the treatment of fluid to said first passage and a means of withdrawing said suspension from said second passage.
More specifically, the casing is adapted to be held in the hand, and the vibratory assembly includes a transducer, such as of the magnetostrictive or piezoelectric type, a removable operative tip and a connecting body in the form of an acoustic impedance transformer for supporting the operative tip and coupling the high frequency vibrations thereto.
The requisite electrical power together with a supply of coolant for the transducer is connected to the housing at the transducer end. A supply of treatment fluid, such as a liquid providing a dispersion medium for the particles to be removed, is coupled through a first passage provided in the housing to an outlet adjacent the operative tip. A source of suction, provided by a suitable pumping means, is coupled via a second passage within the housing to a point adjacent the operative tip.
In using the instrument, alternating electrical energy is ap plied to the transducer to set the operative tip in vibratory motion. As the operative tip is applied to the material, the region adjacent the operative site is bathed or flooded with the treatment fluid while the pumping means is activated to withdraw fluid with suspended particles therein from the region.
The high frequency action of the small area output end of the operative tool tip against the material to be removed rapidly breaks it apart into tiny particles, dispersion of which in the fluid medium is enhanced by the vibratory forces engendered in the medium. The pumping means is then effective to withdraw the resultant suspension from the region of operation. The material to be removed is not only broken apart into small particles, but completely withdrawn from its original location. No subsequent flushing or aspiration procedures are necessary.
In order to keep the incision into the cornea as small as possible, the operative tip has a bore through its center forming a part of one of the passages and there is a tubular sleeve coupled to the casing, surrounding a portion of the operative tip to form an annular space thereabout which is part of the other of said passages.
In order to simplify the problem of changing the operative tips during an operation, the front portion of the casing, referred to as a tubular sleeve, is readily removable to provide access to the operative tip which is also removable from the remaining portion of the vibratory assembly. This tubular sleeve includes a sheath which is composed ofa plastic material. Since this sheath is quite small in diameter, in order to minimize the size of the incision, it would be very difficult to manufacture it from any metallic substance and maintain the proper tolerances to provide for the annular space between it and the operative tip. Also, the resiliency of plastic is necessary to avoid any substantial dampening effect on the vibratory assembly should the sheath contact the operative tip. The heat resistant nature of the plastic material also avoids the transmission of any heat to the cornea from the sheath.
For proper operation of the instrument it is necessary to have certain valve and switch means for selectively operating the source ofelectrical energy, withdrawal means and a line to atmospheric pressure. This is particularly important with respect to an operation in the eye, since it is extremely important to be able to maintain the fluid pressure within the eye within certain limits.
Finally, the vibratory assembly must be supported in some manner within the casing and this is effected by the use of resilient sealing means, an example of which are rubber O rings. These sealing means serve the dual purpose of supporting the vibratory assembly at approximately a node of longitu dinal motion so as to have a minimum effect on dampening the motion and also serve to define one of the fluid passages.
The foregoing and other objects, features and advantages of the invention will become apparent from the following more detailed description thereof when taken in conjunction with the accompanying drawings, in which:
FIG. 1 is a pictorial representation of the entire instrument of the invention showing, in perspective, the handpiece and the supporting equipment;
FIG. 2 is an enlarged pictorial representation of the tool tip shown in use, to aid in explaining its action;
FIG. 3 is a view, mostly in cross section, of the handpiece of the invention showing its internal construction;
FIG. 3A is an enlarged cross-sectional view of the tip end of the handpiece of FIG. 3;
FIG. 43 is an enlarged pictorial representation of the top of the handpiece showing the use of the instrument in cataract removal,
FIGS. 5A through SI show various forms of operative tips for use with the instrument; and
FIG. 6 is a schematic diagram of the foot switch control means for the oscillator and pump valves.
In the ensuing detailed description, the invention will be described in terms of its use as a surgical instrument, particularly as applied to cataract removal. However, it will be un derstood that the principles of the invention are not so limiting, and the apparatus described is capable ofa wide variety of material breaking and removal applications, within and outside the medical field.
Turning HOW to FlG. l, the elements of the instrument of the inventi include a handpiece indicated generally at 10, which is of a size and weight as to be comfortably held in the hand and easily manipulated by the user. As will be described in connec 3, the handpiece 10 includes within its outer housing o casing, transducer means for converting high frequctcy electzical energy into mechanical vibrations of high frequency and small amplitude. The requisite high frequency alternating current electrical energy is supplied by a conven tional oscillator included in the unit indicated generally at 12. Insofar as ability to perform tissue removal is concerned a wide range of frequencies is suitable, for example from 1,000 to 100,000 cycles per second. However, a convenient choice of frequency has been found to be approximately 25,000 cps which permits optimum selection of handpiece components, both with respect to overall size and effectiveness, and also is above the range of human hearing, eliminating annoying audible effects obtained at lower frequencies.
The output of the oscillator in unit 12 is connected by a pair of leads enclosed within the conduit 14 and coupled through the end ofthe handpiece remote from the operative tip. As indicated on the face of the unit 12, the oscillator is provided with suitable frequency and amplitude controls, whereby the precise frequency of operation may be tuned over a range and the amplitude of the electrical signals also may be varied. These controls enable tuning of the instrument to resonance and adjustment of the vibration amplitude ofthe operative tip, in accordance with the needs ofthe user.
The unit l2 also provides a source of cooling water for the handpiece which ordinarily is required to carry away the heat generated by the electrical-to-mechanical energy conversion occurring in the handpiece. For this purpose, the conduit 14 also carries a pair of flexible tubes, one for carrying the coo lant into the handpiece end and the other for withdrawing the coolant therefrom. This provides a circulating system for maintaining the temperature of the handpiece at comfortable levels. Unit l2, as illustrated, is provided with a water control valve for adjusting the cooling flow. The coolant may be obtained from a convenient tap or may be incorporated in a closed circulation system having a small pump and a cooling system for the coolant returned from the handpiece.
The supporting equipment for the handpiece further includes a pump R6 (to be referred to as a withdrawal means) and a treatment fluid supply 20. The pump is coupled via conduit l8 and through an opening in the housing of the handpiece to the interior thereof. In addition to providing a source of suction force for the withdrawal of unwanted particles suspended in the treatment fluid, the pump includes valve means whereby the conduit 18 may be selectively coupled to the pump or opened to atmospheric pressure.
The treatment fluid supply 20, which may include a reservoir of a premixed solution of appropriate type and a suitable pump, or mixing means whereby the required solution is prepared on a continuous basis, is connected through conduit 22 and into the interior of the housing of the handpiece. As will be described in greater detail hereinafter, the handpiece includes internal fluid passages coupled to the conduits l8 and 22 whereby, at the operative tip of the instrument, there may be provided both a flow of treatment fluid and a withdrawal of unwanted particles suspended in the treatment fluid.
A switch 2 3 is provided to enable control of the oscillator and pump during manipulation of the handpiece by the sur geon. The switch 24 may be of any convenient type, preferably resting on the floor and including a control lever 25 adapted to be actuated by the foot selectively between several positions. The switch is coupled via conductors 26 to the oscillator housing 12 and the vacuum pump 16 to control the components thereof, as will be described more fully hereinafter.
The manner in which the instrument is used for tissue removal is illustrated in FIG. 2. In the drawing, 32 indicates a cohesive mass (as distinguished from a collection of discrete particles) of undesired tissue located within a region of healthy tissue 30 below the skin 34. To remove the tissue 32 with the present instrument, a small surgical incision 36 is made through the skin adjacent the mass 32 to enable the operative tip of the handpiece 10 to reach the tissue mass 32. As the tip of the handpiece 10 is inserted through the incision 36 and into contact with the unwanted tissue, the surgeon ac tuates the foot switch 24 to apply alternating current power to the instrument to set the tip into vibration and also to actuate the pump 16.
At the same time, the treatment fluid supply is turned on, at controlled pressure, so that at the operative tip of the tool which is brought into contact with the mass 32, three conditions simultaneously obtain. Firstly, the operative tip vibrates at a high frequency rate and with small amplitude against the tissue mass 32 and in the process breaks it apart into minute particles. Concurrently, the treatment fluid supply, which preferably is a solution compatible with the animal tissue being treated (such as saline), floods or bathes the region at the tip end which is being subjected to the vibratory action. Finally, the suction source at the operative tip simultaneously withdraws from the operative site the resultant suspension of the small particles of removed tissue in the treatment fluid bathing the area. The unwanted tissue thus separated from the host body is removed as it is broken apart and, at the same time, leakage of the treatment fluid outside of the operative site is minimized. An equilibrium condition thus exists at the operative site between the treatment fluid, the withdrawal means, and the small leakage.
In employing the instrument as shown in FIG. 2, the surgeon manipulates the handpiece 10 until all of the unwanted tissue has been broken apart and removed from the operative site. If necessary, additional small incisions 36 may be made at various other surface points to permit ready access to the mass of unwanted tissue. However, each of these incisions need be only sufficiently large to admit the slender operative tip of the instrument. This reduces trauma and speeds recovery time, as compared to a massive surgical excision by the usual procedures.
Although the exact mechanism occurring at the working end of the operative tip, which results in breaking apart of the tissue mass into minute particles, is not fully understood at present, it is believed to be a composite of a cutting action by the relatively sharp tip and a fracturing resulting from the large number of impacts of the vibrating tip. Regardless of precisely how the tissue is fragmented, it has been found that the instrument of the invention effectively breaks apart tissue into minute particles, sufficiently small to pass readily through an opening in the operative tip less than l millimeter in diame I81.
The handpiece itself is shown in cross section in FIGS. 3 and 3A. Substantially all of the operative parts of the handpiece are enclosed within a casing indicated at 40, which includes a generally tubular barrel section 40a, a smaller diameter extension section 40b threaded onto the forward end of the barrel 40a, a forward end cap 400 having a small diameter tubular portion extending therefrom (see FIG. 3A) threadedly engaging the forward end of extension 40b, and a rear closure 40d threadedly engaging the rear portion of the barrel 40a. Preferably, all of the portions of the casing 40 are made of a metal such as stainless steel, which is sterilizable and which also provides shielding for the electrical and magnetic components within the handpiece.
The vibratory assembly contained within the casing 40 is composed of a transducer portion 42 and a connecting body 46, the latter preferably in the form of an acoustic impedance transformer. The transducer element 42 may be of any suita ble type capable of converting high frequency alternating current signals into corresponding longitudinal mechanism vibrations. In the embodiment illustrated, the transducer is composed of a stack of thin sheets of magnetostrictive material such as nickel, Permendur, or other similar material, insulated from each other and firmly secured together such as by brazing at the ends. As shown, the stack is divided by a lengthwise elongated opening effectively separating the stack into two separate vibratory sections, with the coil 44 wound about each section or leg separately, in such fashion as to produce in phase vibration in both legs.
The forward end of the stack 42 is coupled, such as by a threaded connection as shown or by a permanent bond, to the input end of the connecting body 46. Preferably, a washer 43 is provided between the end of the stack and the input surface of the member 46 to render the transmission of vibratory energy to the member 46 more effective.
As indicated above, the connecting body 46 preferably is in the form of an acoustic impedance transformer whereby the amplitude of the longitudinal vibrations induced in the stack 42 may be increased for application to the operative tip of the handpiece. For this purpose, the member 46 may be of the type shown in US. Pat. No. 25,033, assigned to the present assignee, formed of a single piece of vibration transmitting material such as Monel metal, having a relatively massive input section 46a and a relatively slender output section 4612, with a tapered transition region 46c. As described in the aforementioned reissue patent, maximum amplification of longitu dinal vibrations in such a member occurs when both the input and output sections of the transformer are equal in length to one-fourth of the wavelength in the material at the frequency of vibration and each of said sections is substantially uniform along its length in cross-sectional area.
However, in many applications, including use in surgical procedures such as described herein, sufiicient amplitude of vibration may be obtained under less than maximum amplitude conditions. Accordingly, it will be understood that a relatively wide variation in dimensioning of the impedance transformer 46 is permissible to allow the instrument to perform its intended function effectively. in fact, many different types of connecting bodies may be employed.
As described in the aforementioned patents of the present assignee, optimum energy conversion in the magnetostrictive transducer 42 is obtained when the longitudinal dimension of the stack is equal to a half wavelength in the material at the applied driving frequency. Considering, then, the overall vibrating structure consisting of the stack 42 and the impedance transformer 46, it will be seen that, ideally, the combined length would be equal to a full wavelength at the operating frequency, with each of the stack and transformer being equal to a half wavelength. This would place loops of motion at the free ends of the stack and transformer, as well as the juncture of the two components, where a minimum stress point would therefore occur.
At the same time, nodes of longitudinal motion would occur approximately midway along the length of the stack 42 and approximately at the junction of the input section 460 and output section 46b of the transformer. The effects of the high stresses at the junction are minimized by providing the tapered transition 46c.
As described in the aforesaid patents, support of such a vibratory structure is best achieved by mounting means located approximately at a node of longitudinal motion whereby minimum damping of such motion results. In FIG. 3, such mounting means are provided in the form of a pair of resilient rings, generally referred to as 0" rings, located in a pair of spaced grooves extending circumferentially around the input section'46a of the transformer, as close as possible to the transition region where the nodal plane would be located. The rings 48 and 50 are of such diameter that they effect a fluidtight seal between the surface of the transformer input section 460 and the inner wall of the housing barrel 40a.
in addition to the spaced sealing rings 48 and 50, a plurality of screws 52 are provided angularly disposed about the axis of the casing, for the purpose of preventing longitudinal or rotational movement of the vibratory structure within the casing and also for radially centering the vibratory structure within the casing. By adjusting the several screws, concentricity of the interior elements of the handpiece and the casing sections may be obtained.
The sealing rings 48 and 50 divide the interior volume of the housing 40 into three independent fluid chambers. The ring 48 in conjunction with the end closure means to be described hereinafter will form a first chamber in which are disposed the magnetostrictive stack 42 and a portion of the transformer input section 46a. An annular chamber of relatively short axial dimension is formed between the two O-rings 48 and 50, and a third chamber is formed forwardly of the ring 50 including the free space within the casing extension 40b.
The rear portion of the casing barrel 40 is sealed off by means ofa grommet 55 which is press fitted into the end of the barrel to form a watertight seal therewith. The grommet is provided with openings through which the electrical leads 45 pass from the conduit 14 to the coil 44. In addition, a coolant fluid inlet tube 54 passes through the grommet 52 and extends within the barrel 40a to a point adjacent the forward end of the stack 42. Fluid outlet tube 56 is also passed through the grommet 52 and into the conduit 14 along with the tube 54. The cooling water supply continually flows into the chamber enclosing the magnetostrictive element from the tube 54, and is withdrawn through the outlet tube 56 after passing over the heat producing elements. It will be understood that the leads 45 and conduits 54 and 56 pass through the grommet 52 in fluid tight relationship.
To provide strain relief for the conduit 14 and minimize entanglement, a wire coil 15 may be wrapped around the portion of the conduit 14 adjacent the handpiece, in place of the plastic tubing enclosing the remainder of the conduit. The coil 15 engages a helical groove provided internally of a retaining element 41. The latter element is compressed about the coil 15 and firmly retained against movement by the threaded cap 40d.
The impedance transformer 46 is provided with an axial bore 47 extending from the free or forward end of the output section 46b and into the input section 460, to a point between the two sealing rings 48, 50. A radial bore 47a connects the bore 47 to the periphery of the transformer 46 and into the annularchamber between the sealing rings. Nipple 56 is connected to the periphery of the handpiece barrel we and is provided with an internal bore extending through the casing and communicating with the annular chamber between the rings 48 and 50 and thus with the bore 497 via the radial bore 470.
A second nipple 58 is connected to the casing extension 30]; at a point near its threaded coupling to the barrel 40a. The latter nipple includes an internal passage communicating with the annular chamber extending forwardly of the sealing ring 50 and including the space between the impedance transformer 46 and the inner walls of the casing sections. As shown best in FlG 3A, this latter chamber extends past the free end of the output section of the connecting body 46b and through the cap Mic.
The operative tool or tip which actually comes into contact with the material to be broken apart and removed is designated by the numeral 60. Referring to H6. 5A, the tip (at) is elongated and provided with a thickened shank portion 604: which preferably is formed with at least a pair of flats to accommodate a wrench for tightening. A threaded connection portion MM is formed integrally with the base portion 60a, and a washer 600, of efficient vibration-transmitting material, is disposed adjacent the shoulder between the portion 60a and 60b. The other end of the tip 60 is shaped in a manner dependent upon the particular type of material or tissue to be broken apart and removed and the shape of the portion to be removed or its surrounding material. In FIG. 5A an acute-angled taper is provided to leave a relatively sharp, rounded edge 60d. An axial bore 6th? extends completely through the tip 60 to provide a fluid passage from threaded end 60!) to the outer or working end ofthe tip.
Referring back now to FIG. 3A, the bore 47 in the transformer 46 is provided at the free end of the output section with internal threads adapted to receive the threaded portion 60b of the tip (it). To attach the tip 60, or to replace one already in position, the end cap 400 is threadedly disengaged from the casing extension 40!; and slid backover and away from the tip 6Q. A small wrench may be used to engage the flats on the base section 60a to remove a tip already in place or to snugly in rt anew tip. The end cap 400 is then replaced and the tool is assembled for use.
The operative tip it), being firmly coupled to the output end of the impedance transformer 46, will be longitudinally vibrated thereby at the operating frequency and essentially with the amplitude available at the end of the output section 46b. The operative tip 6'1 preferably is formed of an extremely hard, sterilizable material, such as titanium, and for most surgical applications is made of extremely small dimension. For example, in the instrument as used for cataract removal operations, the operative tip had an outside diameter of approximately 1 millimeter. Since this is the only portion of the instrument that is brought into contact with the tissue to be broken apart and removed, it will be evident that only a very short incision need to made in the outer surface to permit access of the tip.
Where the material to be broken apart and removed is relatively deep below the surface, it is undesirable for the shank of the operating tip to be brought into contact with the surrounding tissue, especially if that tissue is healthy and not to be removed. Since the tip 60 is vibrating at a high frequency, heat will be developed due to the rubbing action and damage to delicate tissues can result.
To avoid this possibility, a sheath 64 of a strong, heat-resistant and inert material, such as the plastic known as Teflon, is provided. As shown best in FIG. 3A, the sheath 64 is provided with an axial bore of a diameter somewhat greater than the outer diameter of the tip 60 and has a base section with a counterbore that snugly engages the tubular portion extending from the forward end of the end cap 400. The fit between the latter two parts is made such that the sheath 64 may be secured to the end cap 400 with manual pressure but will not shake loose under normal usage.
The barrel of the sheath 64 extends along a considerable length of the operative tip 60 and has an outer diameter of sufficient thickness to provide the necessary structural rigidity. Preferably, it is slightly tapered, as shown. The annular clearance between the inner surface of the sheath s4 and the outer surface of the operative tip 60 serves as an extension of the fluid passage formed between the transformer section 46); and the casing extension 40)).
As will be explained in greater detail in connection with HO. 6, alternating current electrical energy having a superimposed direct voltage bias thereon is coupled from the unit 12 and via conductors 45 to the coil on the transducer 42. The vibratory structure is thereby set into longitudinal vibration at the oscillator frequency, with the consequent vibration of the operative tip 6h. For purposes of example, the amplitude of the alternating current supply may be set such that the work ing end of the tip 6 0 has a stroke amplitude of approximately 0.003 inch. At the same time, of course, a coolant supply is circulating in the chamber housing the transducer structure.
As the operative tip is brought into contact with the material to be broken apart and removed, treatment fluid from the supply 2b is provided through the conduit 22 and the nipple 53 to the passage formed between the connecting body 46 and the casing extension 40b and thence through the annular space between the cap 400, sheath 45 i, and the tip 60. The tissue adjacent the operating tip is thereby bathed with the treatment fluid.
The treatment fluid serves two purposes. in addition to maintaining the operative tip relatively cool during use, thereby reducing possible harm to healthy tissue, it provides a dispersion medium in which particles of tissue are suspended as they are broken away from the tissue mass. it will of course be realized that the treatment fluid is being brought into direct contact with delicate tissue and accordingly must be of a neutral nature. In the case of cataract removal, for example, a balanced isotonic saline solution is suitable for this purpose.
Withdrawal of the suspension of the tissue particles in the treatment fluid is effected through the hollow operative tip, the bore 47 in the transformer 46, the connecting passage 47a and nipple 56, through the conduit l8 and to the withdrawal means, for example a pump l6. During the operative procedure, the volume oftreatment fluid supply is controlled, along with the pump operation, so that a proper amount of treatment fluid is maintained at the operative site and overflow is minimized.
The use of the instrument of the invention as applied to cataract removal is illustrated in FIG. 4. A portion of a simplified cross section of a human eye is shown to illustrate the manner in which the device is employed. The opaque lens or cataract which is to be broken apart and removed to is designated by the numeral 72 and is encased in a membrane including an outer portion 72a known as the anterior capsule and a rear portion 7211 known as the posterior capsule. The iris is designated by the numeral '74 and the major gel-filled portion of the eye, or vitreous, is shown at 76. The cornea, the transparent outer surface of the eye, is shown at 70.
To avoid having to pierce or cut the iris, suitable drugs are administered to dilate the iris to its maximum extent, so that as much of the anterior capsule 72a is exposed as is possible. A small incision 78 is then made in the transparent cornea fluid as far as possible from the center of the pupil area. This incision need only be about l to 3 mm. in length to provide proper access for the operative tip ofthe vibratory assembly.
The anterior capsule 72a is penetrated, first, either by the operative tip of the vibrating assembly or with a surgical in strument. Once an opening in the anterior capsule has been made, such as indicated in FIG. 4, the operative tip is inserted into the body of the cataract 72, whereby the lens tissue mass is broken apart into minute particles. During this portion of the operation, the transducer is energized and the pump is activated to provide suction force at the operative tip, along with a supply oftreatment fluid.
In the space ofa few minutes, all of the cataract tissue 72 is broken apart and the particles, together with the fluid in which they are suspended, withdrawn by the instrument. Thereafter,
the remnants of the anterior capsule and the posterior capsule are withdrawn with capsule forceps. This completes the cataract removal. The small incision 78 is subsequently sutured to conclude the surgical procedure. As compared to the conventional cataract removal, which requires a 180 incision around the cornea, trauma to the patient and recovery time are substantially reduced.
In FIG. 4, the operative tip of the vibratory assembly is illustrated as inserted into the eye with the plastic sheath 64 in place. As the surgeon maneuvers the instrument to reach all of the cataract tissue, any contact that occurs between the instrument and the other parts of the eye is on the sheath, which is not vibrating and therefore cannot damage any of the delicate tissue. In this instance, the sheath also serves to discharge the treatment fluid more directly atthe operative site. It will be understood of course, that the sleeve 64 may be removed and the operative tip employed without it where operative conditions permit.
In the cataract removal procedure, the treatment fluid supply serves a purpose in addition to providing a dispersion medium for the particles of unwanted tissue and a coolant for the operative tip, by serving to maintain sufficient pressure within the anterior chamber of the eye, between the anterior capsule 72a and the cornea 70, whereby collapse of the latter is avoided. v
The operative tip 60 shown in detail in FIG. A is but one of a number of different forms of operative tip that may be employed with the instrument of the present invention. When used for cataract removal, it will be seen that the straight tapered tip shown in FIG. SA will not be able to reach all of the lens tissue within the lens membrane without incurring the danger of piercing the vitreous. To clean out the portions of the lens tissue clinging to relatively inaccessible corners of the lens membrane, operative tips having other shapes are employed. Several possible configurations for this and other purposes are shown in FIGS. 58 to SI.
FIGS. 5B and 5C illustrate, respectively, a symmetrically straight tapered tip end and a symmetrically rounded taper tip end. FIGS. 5D and 5E are two views ofa tip having a relatively blunt end and an opening angled to the axis of the main portion of the tip to provide a spoon shape. Such a tip is used to reach the inaccessible corners of the lens capsule without risking damage to or possible puncture of the vitreous.
FIGS. 5F and 5G and FIGS. 5H and SI show two additional forms of operative tips, each of which incorporates a sharp projection such as might be used for puncturing the anterior capsule of the eye.
The forgoing tip designs represent but a few of the many possible variations which may be employed in the large number of tissue breaking apart and removal applications that can be accomplished with the present instrument.
A suitable switch control a arrangement for the oscillator and coolant supply 12 and the pump 16 (FIG. 1) is shown in FIG. 6. The pump 16 includes two input lines, 80 and 82, and a discharge line 92 to a drain or waste line. The pump preferably is of the continuous acting type and therefore is either pumping fluid from a sump or reservoir through input line 80 or from the operative site through the handpiece and conduits l8 and 82. Control of the conduits 80 and 82 is effected by solenoid valves 86 and 88 respectively, so that the pump is pulling fluid through one or the other at any given time.
Under certain conditions, during the course of surgical procedures, it may be desired not to withdraw fluid from the operative site, but merely to maintain a static pressure condition thereat. For this purpose, an additional conduit 84 is coupled to in the input line 82 under control of an additional solenoid valve 90.
The switch 24, having a foot-actuated control arm 25, not only controls the operation of the pump 16 but also the application of energy from the oscillator in unit 12 to the coil on the handpiece transducer. As shown in FIG. 6, the switch has three positions, A, B, and C, the position A having a pair of spaced contacts'94, the position B having a pair of spaced contacts 96, and position C having two pairs of spaced contacts 98 and 100. The switch arm 25 is pivoted at one end and includes a pair of spaced conductive segments 25a and 25b, separated by insulating material. When in position C, as shown in the drawing, the segment 25a bridges the contact pair 98 while the segment 25b bridges the contact pair 100. In positions A and B, the segment 25a bridges the contact pairs 94 and 96 respectively.
A source of operating voltage 102 is coupled to one contact of each of the contact pairs 94, 96 and 98. The other contact of contact pair 94 is coupled to the inputs of both solenoid valves 86 and 90. The other contacts of pairs 96 and 98 are connected in common to the control input of solenoid valve 88. The contact pair 100 interrupts a lead from the oscillator 12 to the handpiece whereby energy is delivered to the latter only when the segment 25b bridges the contact 100, as shown.
The switch arm 25 is spring urged, such as by a coil spring 104, so that its normal position is in position A, bridging contacts 94. Each of the solenoid valves 86, 88 and are normally in their closed position, that is, with no electrical power supplied to their control inputs, they close the channels in which they are interposed.
With the switch are in position A, the contacts 94 are bridged, permitting connection of the source 102 to both valves 86 and 90. These two valves are thus opened, connecting the pump input to the reservoir or sump and opening the conduit 18 to atmospheric pressure. The valve 88 remains closed.
With the switch arm in position B, bridging contacts 96, valve 88 is opened while valves 86 and 90 remain closed. The pump 16 then is coupled directly to the conduit 18 and thus provides a suction force at the tip of the handpiece. It will be noted, that in both positions A and B, the output of the oscillator 12 is not connected to the handpiece and consequently, the operative tip 60 is not set into vibratory motion.
With the switch arm in position C as shown, valve 88 is opened, valves 86 and 90 are closed and the biassed alternating current output of the oscillator is coupled to the hand piece. This establishes the full operative condition of the handpiece, i.e., high frequency vibration of the operative tip and the establishment of a suction force to withdraw fluid from the operative site.
During the operative procedure, control of the treatment fluid supply will be maintained preferably by an assistant to the operating surgeon. Depending upon his needs at the moment, the surgeon will direct the assistant to control the pressure of the fluid supply, between an Off" or no supply position and a High condition, under which maximum flow into the operative site is obtained. (See FIG. 1). At the same time, the amplitude of the oscillator output will be controlled to produce the proper stroke amplitude at the operative tip. Adjustment of the latter is desirable to permit both removal in gross of unwanted tissue as well as the cleaning up of small bits of material where care must be exercised to avoid damaging surrounding tissue.
It will be apparent from the foregoing, that a novel, improved form of material breaking apart and removal apparatus has been disclosed, by means of which unwanted material, such as animal tissue, may be broken apart into minute particles and removed rapidly and with a minimum of damage to surrounding materials. By virtue of the controlled fluid supply and pump, material may be removed from the operative site as it is broken apart thereby eliminating the necessity for subsequent cleansing operations and minimizing obscuring of the operative site during the procedure.
It will also be recognized that many variations of the particular apparatus disclosed will occur to those skilled in the art, without departing from the spirit of the invention, For example, the flow passages for the treatment fluid supply to the operative site and the withdrawal of the suspension from the operative site may be interchanged, such that the fluid is transmitted through the hollow operative tip and withdrawn llll through the annular space between the tip and the sleeve 64. Moreover, more sophisticated control arrangements for the oscillator pump and treatment fluid supply may be employed and various other tip shapes are possible, within the teaching of the present invention. Accordingly, the invention is to be deemed limited only by the scope ofthe appended claims.
1. Apparatus for the breaking apart and removal of animal tissue from an enclosed area, an elongated working tip adapted to have one end placed directly against the tissue and capable of supporting ultrasonic vibrations, means for apply ing ultrasonic vibrations of variable amplitude and duration to said working tip, means for supplying a treatment fluid to bathe said tissue in the region adjacent said working tip, and pumping means adjacent said working tip for withdrawing the suspension of particles of said tissue of said fluid resulting from ultrasonic vibration ofsaid working tip.
2. Apparatus for the breaking apart and removal of animal tissue and the like comprising, an elongated, hollow working tip adapted to have one end placed against the tissue to be removed and capable of supporting ultrasonic vibrations, means for applying ultrasonic vibrations to said working tip, means including a tubular sleeve surrounding a portion of said working tip for providing a first fluid passage between said tip and a point remote therefrom, means coupled to said tip for providing a second fluid passage between the hollow interior of said tip and a point remote therefrom, means for supplying a fluid to one of said passages and means for applying a suction force to the other ofs aid passages.
3. A surgical instrument adapted to be held in the hand and moved freely during operative use comprising, a casing of size and configuration comfortable to the hand, transducer means within said casing for generating high frequency mechanical vibrations upon excitation with a high frequency alternating current electrical signal, an operative tool external of said casing and coupled to said transducer means to be vibrated thereby, a first fluid passage extending through said casing and in surrounding relation to at least a portion of said operative tool, and a s cond passage formed in part internally of said operative tcoi and extending into said casing, one of said passages being adapted to conduct a fluid to said operative tool and the other of said passages being adapted to withdraw fluid from the. gion adjacent said operative tool.
[tppa according to claim 3 above wherein said operative tool as elongated and formed with an axial bore providing a part ofsaid passage.
5. Apparatus according to claim 3 above wherein said casing includes an extension surrounding and spaced from the peripheral surface ofa portion of said tool, the space between the inner surface of said casing extension and said peripheral surface ofsaid took providing a part ofsaid first passage.
6. Apparatus according to claim 3 wherein said transducer means includes an acoustic impedance transformer having a relatively massive input section and a relatively slender output section, said output section extending within said casing extension and being coupled at its free end to said too], said output section having a cross-sectional area smaller than the internal cross-sectional area of said casing extension, the spacing therebetween forming a continuation of said first passage, said transformer further having an axial bore extending from the free end of said output section to a point within said input section, and a radial bore from said axial bore to the periphery of said input section, said axial and radial bores forming a continuation of said second passage.
7. Apparatus according to claim 6 above further comprising a pair of spaced-apart resilient sealing means around said input section of said transformer within said casing, each of said sealing means providing a circumferential fluidtight seal between said input section and said casing, the peripheral opening of said radial bore being between said sealing means.
8. Apparatus according to claim 6 above further comprising a first opening in said casing located between said sealing means, a second opening in said casing located between said casing extension and the sealing means closest to the output section of said transformer, and means mounted exteriorly of said casing adjacent each of said openings adapted to be con nected to a fluid conduit.
9. A surgical instrument for breaking apart and removing unwanted material comprising, a handpiece including transducer means for converting high frequency alternating current into high frequency mechanical vibrations, an operative tip coupled to said transducer means to be vibrated thereby, said tip having an axial bore therethrough defining a first passage sleeve means surrounding and spaced from said tip defining a second passage, a source of high frequency alternating current coupled to said transducer, a source of treatment fluid coupled to one of said passages, pumping means coupled to the other passage for withdrawing a suspension of unwanted material in said treatment fluid, and switch means for controlling the application of said alternating current and the suction force provided by said pumping means to said handpiece.
W. The apparatus of claim 9 further comprising valve means interposed between said pumping means and said handpiece, and control means for said valve means for selectively coupling the axial bore in said tip to said pumping means or to atmospheric pressure.
11. The apparatus of claim 10 wherein said switch means includes a control member selectively movable between a first position in which no alternating current is supplied to said transducer means and said valve control means couples the axial bore in said tip to atmospheric pressure, a second position in which no alternating current is supplied to said transducer means and said valve control means couples the axial bore in said tip to said pumping means, and a third position in which alternating current is supplied to said transducer means and said valve control means couples the axial bore in said tip to said pumping means.
12. The apparatus of claim 9 wherein said sleeve means in cludes a readily removable sheath extending to a point closely adjacent the free end of said operative said sheath being formed ofa relatively hard, heat resistant, plastic material.
13. The apparatus of claim 3 wherein said casing is formed ofa material providing a magnetic and electrical shield for the components enclosed therein.
14. The apparatus of claim 9 wherein said source of fluid includes control means for maintaining the pressure ofsaid fluid at a level such that an equilibrium condition between supply and removal offluid at the operative site may be maintained.
i5. Method for the breaking apart and removal of a cohesive mass of unwanted material from an enclosed area comprising the simultaneous steps of, applying high frequency vibrations directly to the unwanted material to reduce said mass of material to small particles, bathing the material in the region in which said vibrations are applies with a treatment fluid, and withdrawing the resulting suspension of particles in said treatment fluid.
16. Method for the breaking apart and removal of animal tissue and the like from an enclosed area, employing an elongated working tip comprising the simultaneous steps of, apply ing ultrasonic vibrations of variable amplitude and duration to said working tip in contact with said tissue, supplying a treatment fluid to bathe said tissue in the region adjacent said working tip, and withdrawing the suspension of particles of said tissue in said fluid so that the pressure within the enclosed area is controlled.
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3075288 *||24 Dec 1954||29 Jan 1963||Cavitron Ultrasonics Inc||Dental instrument|
|US3076904 *||29 Aug 1958||5 Feb 1963||Cavitron Corp||Acoustically vibrated material cutting and removing devices|
|US3213537 *||11 Sep 1961||26 Oct 1965||Cavitron Corp||Supply and control apparatus for vibratory cutting device|
|US3352303 *||28 Jul 1965||14 Nov 1967||Lawrence J Delaney||Method for blood clot lysis|
|US3358677 *||23 Oct 1964||19 Dec 1967||Sheldon Edward Emanuel||Supersonic therapeutic device with means for introducing fluid into a body cavity|
|US3380446 *||3 Sep 1965||30 Apr 1968||Leonard G. Martin||Dental applicator|
|CH415949A *||Title not available|
|FR1429637A *||Title not available|
|GB790277A *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3693613 *||9 Dec 1970||26 Sep 1972||Cavitron Corp||Surgical handpiece and flow control system for use therewith|
|US3736938 *||15 Nov 1971||5 Jun 1973||Nasa||Ophthalmic method and apparatus|
|US3805787 *||16 Jun 1972||23 Apr 1974||Surgical Design Corp||Ultrasonic surgical instrument|
|US3818913 *||30 Aug 1972||25 Jun 1974||Wallach M||Surgical apparatus for removal of tissue|
|US3882872 *||25 Apr 1973||13 May 1975||Henry T Dinkelkamp||Method and apparatus for cataract surgery|
|US3908661 *||31 Jan 1974||30 Sep 1975||Steven G Kramer||Surgical instruments|
|US3930505 *||2 Dec 1974||6 Jan 1976||Hydro Pulse Corporation||Surgical apparatus for removal of tissue|
|US3941122 *||8 Apr 1974||2 Mar 1976||Bolt Beranek And Newman, Inc.||High frequency ultrasonic process and apparatus for selectively dissolving and removing unwanted solid and semi-solid materials and the like|
|US3942519 *||12 Aug 1974||9 Mar 1976||Ultrasonic Systems, Inc.||Method of ultrasonic cryogenic cataract removal|
|US3952732 *||21 Oct 1974||27 Apr 1976||Shock John P||Ultrasonic cataract removal method and apparatus|
|US3956826 *||19 Mar 1974||18 May 1976||Cavitron Corporation||Ultrasonic device and method|
|US3990452 *||13 Jun 1975||9 Nov 1976||Fibra-Sonics, Inc.||Medical machine for performing surgery and treating using ultrasonic energy|
|US3996935 *||18 Jan 1973||14 Dec 1976||Surgical Design Corporation||Surgical-type method for removing material|
|US4016882 *||5 Mar 1975||12 Apr 1977||Cavitron Corporation||Neurosonic aspirator and method|
|US4033349 *||13 Apr 1976||5 Jul 1977||The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration||Corneal seal device|
|US4041947 *||23 Jun 1975||16 Aug 1977||Cavitron Corporation||Flow control system|
|US4047532 *||21 Apr 1975||13 Sep 1977||Phillips Jack L||Vacuum forcep and method of using same|
|US4052987 *||1 Apr 1976||11 Oct 1977||Cavitron Corporation||Automatic aspiration apparatus|
|US4063557 *||1 Apr 1976||20 Dec 1977||Cavitron Corporation||Ultrasonic aspirator|
|US4078564 *||24 Feb 1976||14 Mar 1978||Novo Enzyme Corporation||Intralenticular cataract surgery|
|US4135516 *||24 Feb 1977||23 Jan 1979||Novo Laboratories, Incorporated||Delivery apparatus and method for treatment of intralenticular cataracts with exogenous enzymes|
|US4191176 *||23 Aug 1977||4 Mar 1980||Novo Laboratories, Inc.||Intralenticular cataract surgery|
|US4204328 *||14 Nov 1977||27 May 1980||Kutner Barry S||Variable diameter aspirating tip|
|US4223676 *||19 Dec 1977||23 Sep 1980||Cavitron Corporation||Ultrasonic aspirator|
|US4274411 *||30 Mar 1979||23 Jun 1981||Dotson Robert S Jun||Fluid operated ophthalmic irrigation and aspiration device|
|US4314560 *||28 Nov 1979||9 Feb 1982||Helfgott Maxwell A||Powered handpiece for endophthalmic surgery|
|US4316465 *||29 Nov 1979||23 Feb 1982||Dotson Robert S Jun||Ophthalmic handpiece with pneumatically operated cutter|
|US4332558 *||20 May 1980||1 Jun 1982||Lustig Leopold P||Dental scaling apparatus|
|US4411652 *||21 Aug 1981||25 Oct 1983||The Regents Of The University Of California||Internally sterile pulsatile infusor system|
|US4417578 *||20 Mar 1981||29 Nov 1983||Surgical Design||Ultrasonic transducer with energy shielding|
|US4493694 *||25 May 1984||15 Jan 1985||Cooper Lasersonics, Inc.||Surgical pre-aspirator|
|US4504264 *||24 Sep 1982||12 Mar 1985||Kelman Charles D||Apparatus for and method of removal of material using ultrasonic vibraton|
|US4515583 *||17 Oct 1983||7 May 1985||Coopervision, Inc.||Operative elliptical probe for ultrasonic surgical instrument and method of its use|
|US4516398 *||5 Jun 1984||14 May 1985||Cooper Lasersonics, Inc.||Method of use of an ultrasonic surgical pre-aspirator having a orifice by-pass|
|US4528979 *||18 Mar 1982||16 Jul 1985||Kievsky Nauchno-Issledovatelsky Institut Otolaringologii Imeni Professora A.S. Kolomiiobenka||Cryo-ultrasonic surgical instrument|
|US4530356 *||8 Feb 1983||23 Jul 1985||Helfgott Maxwell A||Ophthalmic surgical instrument with beveled tip|
|US4535759 *||30 Sep 1982||20 Aug 1985||Cabot Medical Corporation||Ultrasonic medical instrument|
|US4542542 *||21 Jul 1983||24 Sep 1985||Innovative Surgical Products, Inc.||Correction of defects in the eye and compositions therefor|
|US4608050 *||21 Jul 1983||26 Aug 1986||Innovative Surgical Products, Inc.||Correction of defects in the eye and compositions therefor|
|US4634420 *||31 Oct 1984||6 Jan 1987||United Sonics Incorporated||Apparatus and method for removing tissue mass from an organism|
|US4634423 *||30 Apr 1984||6 Jan 1987||Bailey Jr Paul F||Ophthalmological method and instrument for implantation of posterior chamber intraocular lens|
|US4643717 *||16 Sep 1985||17 Feb 1987||Site Microsurgical Systems, Inc.||Aspiration fitting adaptor|
|US4655197 *||1 Dec 1982||7 Apr 1987||Snyder Laboratories, Inc.||Lavage system with variable frequency, flow rate and pressure|
|US4660573 *||8 May 1985||28 Apr 1987||Fibra-Sonics, Inc.||Ultrasonic lithotriptor probe|
|US4672965 *||16 Aug 1984||16 Jun 1987||Gilbert Baum||Surgical apparatus|
|US4683884 *||11 Apr 1986||4 Aug 1987||Md Engineering||Noise attenuating smokeless surgical device|
|US4689040 *||29 Apr 1985||25 Aug 1987||Thompson Robert J||Tip for a phacoemulsification needle|
|US4692139 *||30 Sep 1985||8 Sep 1987||Stiles Frank B||Catheter for effecting removal of obstructions from a biological duct|
|US4713051 *||21 May 1985||15 Dec 1987||Coopervision, Inc.||Cassette for surgical irrigation and aspiration and sterile package therefor|
|US4731079 *||26 Nov 1986||15 Mar 1988||Kingston Technologies, Inc.||Intraocular lenses|
|US4741731 *||19 Feb 1986||3 May 1988||Fibra-Sonics, Inc.||Vented ultrasonic transducer for surgical handpiece|
|US4747820 *||9 Apr 1986||31 May 1988||Cooper Lasersonics, Inc.||Irrigation/aspiration manifold and fittings for ultrasonic surgical aspiration system|
|US4750488 *||27 Feb 1987||14 Jun 1988||Sonomed Technology, Inc.||Vibration apparatus preferably for endoscopic ultrasonic aspirator|
|US4750902 *||19 May 1986||14 Jun 1988||Sonomed Technology, Inc.||Endoscopic ultrasonic aspirators|
|US4787889 *||9 Nov 1987||29 Nov 1988||Coopervision, Inc.||Rigid, transparent fluid conduit for surgical irrigation|
|US4808154 *||26 Oct 1983||28 Feb 1989||Freeman Jerre M||Phacoemulsification/irrigation and aspiration sleeve apparatus|
|US4827911 *||2 Apr 1986||9 May 1989||Cooper Lasersonics, Inc.||Method and apparatus for ultrasonic surgical fragmentation and removal of tissue|
|US4832021 *||30 Oct 1987||23 May 1989||Cooper Lasersonics, Inc.||Apparatus and method for assembly and disassembly of interchangeable surgical acoustic members|
|US4832683 *||15 Jul 1986||23 May 1989||Sumitomo Bakellite Company Limited||Surgical instrument|
|US4838853 *||5 Feb 1987||13 Jun 1989||Interventional Technologies Inc.||Apparatus for trimming meniscus|
|US4846790 *||26 May 1988||11 Jul 1989||Cooper Lasersonics, Inc.||Ultrasonic surgical system with irrigation manifold|
|US4861332 *||26 Nov 1986||29 Aug 1989||Ultramed Corporation||Ultrasonic probe|
|US4869715 *||21 Apr 1988||26 Sep 1989||Sherburne Fred S||Ultrasonic cone and method of construction|
|US4870953 *||13 Nov 1987||3 Oct 1989||Donmicheal T Anthony||Intravascular ultrasonic catheter/probe and method for treating intravascular blockage|
|US4908015 *||26 Jul 1988||13 Mar 1990||Anis Aziz Y||Cataract removal technique|
|US4921476 *||2 May 1988||1 May 1990||Cavitron, Inc.||Method for preventing clogging of a surgical aspirator|
|US4921477 *||21 Jun 1989||1 May 1990||The Cooper Companies, Inc.||Surgical irrigation and aspiration system with dampening device|
|US4922902 *||16 Dec 1987||8 May 1990||Valleylab, Inc.||Method for removing cellular material with endoscopic ultrasonic aspirator|
|US4931047 *||30 Sep 1987||5 Jun 1990||Cavitron, Inc.||Method and apparatus for providing enhanced tissue fragmentation and/or hemostasis|
|US4935005 *||1 Feb 1989||19 Jun 1990||Nestle, S.A.||Opthalmic fluid flow control system|
|US4989583 *||21 Oct 1988||5 Feb 1991||Nestle S.A.||Ultrasonic cutting tip assembly|
|US5011471 *||23 Dec 1988||30 Apr 1991||Sumitomo Bakelite Company Limited||Excretions treating apparatus|
|US5015227 *||3 Apr 1990||14 May 1991||Valleylab Inc.||Apparatus for providing enhanced tissue fragmentation and/or hemostasis|
|US5019037 *||6 Jul 1989||28 May 1991||Alcon Laboratories, Inc.||Pneumatic retinopexy injector|
|US5057098 *||16 Sep 1988||15 Oct 1991||Ophthalmocare, Inc.||Apparatus and method for extracting cataract tissue|
|US5058590 *||1 May 1989||22 Oct 1991||Richard Wolf Gmbh||Apparatus for dispersing fluids for dissolution or concretions in a bodily cavity|
|US5066276 *||9 Jun 1989||19 Nov 1991||Alcon Laboratories, Inc.||Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control|
|US5084012 *||22 Mar 1991||28 Jan 1992||Kelman Charles D||Apparatus and method for irrigation and aspiration of interior regions of the human eye|
|US5112300 *||3 Apr 1990||12 May 1992||Alcon Surgical, Inc.||Method and apparatus for controlling ultrasonic fragmentation of body tissue|
|US5112339 *||18 Jun 1990||12 May 1992||Ophthalmocare, Inc.||Apparatus for extracting cataractous tissue|
|US5120307 *||22 Aug 1990||9 Jun 1992||Alcon Laboratories, Inc.||Method for injecting viscous fluid into the eye to life retinal membrane|
|US5123903 *||7 Feb 1991||23 Jun 1992||Medical Products Development, Inc.||Disposable aspiration sleeve for ultrasonic lipectomy|
|US5135481 *||9 May 1990||4 Aug 1992||Marwan Nemeh||Ophthamalic cannula|
|US5139504 *||22 Jul 1991||18 Aug 1992||Ophthalmocare, Inc.||Apparatus, system, and method for softening and extracting cataractous tissue|
|US5154694 *||8 Mar 1991||13 Oct 1992||Kelman Charles D||Tissue scraper device for medical use|
|US5154696 *||8 Apr 1991||13 Oct 1992||Shearing Steven P||Phacoemulsification, irrigation and aspiration method and apparatus|
|US5157603 *||20 Nov 1989||20 Oct 1992||Storz Instrument Company||Control system for ophthalmic surgical instruments|
|US5167619 *||25 May 1990||1 Dec 1992||Sonokineticss Group||Apparatus and method for removal of cement from bone cavities|
|US5176677 *||17 Nov 1989||5 Jan 1993||Sonokinetics Group||Endoscopic ultrasonic rotary electro-cauterizing aspirator|
|US5185002 *||28 Jun 1991||9 Feb 1993||Alcon Surgical, Inc.||Transducer apparatus having water hammer dampening means|
|US5188589 *||10 Oct 1991||23 Feb 1993||Alcon Surgical, Inc.||Textured irrigating sleeve|
|US5190517 *||6 Jun 1991||2 Mar 1993||Valleylab Inc.||Electrosurgical and ultrasonic surgical system|
|US5199943 *||12 Dec 1991||6 Apr 1993||Alcon Surgical, Inc.||Ultrasonic surgical handpiece|
|US5205817 *||17 May 1990||27 Apr 1993||Sumitomo Bakelite Company Limited||Surgical instrument|
|US5209221 *||20 Sep 1991||11 May 1993||Richard Wolf Gmbh||Ultrasonic treatment of pathological tissue|
|US5221282 *||21 Oct 1992||22 Jun 1993||Sonokinetics Group||Tapered tip ultrasonic aspirator|
|US5222960 *||5 May 1992||29 Jun 1993||Poley Brooks J||Cracking and rotating cataract for removal from eye|
|US5243986 *||15 Oct 1991||14 Sep 1993||Richard Wolf Gmbh||Dissolution of concretions in a bodily cavity|
|US5243997 *||14 Sep 1992||14 Sep 1993||Interventional Technologies, Inc.||Vibrating device for a guide wire|
|US5254082 *||9 Apr 1991||19 Oct 1993||Haruo Takase||Ultrasonic surgical scalpel|
|US5267954 *||5 May 1992||7 Dec 1993||Baxter International Inc.||Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels|
|US5284484 *||29 May 1991||8 Feb 1994||Advanced Osseous Technologies, Inc.||Apparatus for implantation and extraction of osteal prostheses|
|US5286256 *||30 Dec 1992||15 Feb 1994||Mackool Richard J||Fluid infusion sleeve|
|US5304115 *||11 Jan 1991||19 Apr 1994||Baxter International Inc.||Ultrasonic angioplasty device incorporating improved transmission member and ablation probe|
|US5318570 *||11 Jun 1991||7 Jun 1994||Advanced Osseous Technologies, Inc.||Ultrasonic tool|
|US5324255 *||10 Jul 1992||28 Jun 1994||Baxter International Inc.||Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasopasm|
|US5324297 *||5 Mar 1991||28 Jun 1994||Advanced Osseous Technologies, Inc.||Ultrasonic tool connector|
|US5328481 *||16 Sep 1991||12 Jul 1994||Alcon Laboratories, Inc.||Method for injecting viscous fluid into the eye to lift retinal membrane|
|US5334183 *||9 Apr 1992||2 Aug 1994||Valleylab, Inc.||Endoscopic electrosurgical apparatus|
|US5342292 *||24 May 1993||30 Aug 1994||Baxter International Inc.||Ultrasonic ablation device adapted for guidewire passage|
|US5342293 *||22 Jun 1993||30 Aug 1994||Allergan, Inc.||Variable vacuum/variable flow phacoemulsification method|
|US5344395 *||24 Jan 1992||6 Sep 1994||Scimed Life Systems, Inc.||Apparatus for intravascular cavitation or delivery of low frequency mechanical energy|
|US5358505 *||22 Jun 1993||25 Oct 1994||Sonokinetics, Inc.||Tapered tip ultrasonic aspiration method|
|US5359996 *||26 Sep 1990||1 Nov 1994||Nestle, S.A.||Ultrasonic cutting tip and assembly|
|US5360398 *||4 Nov 1993||1 Nov 1994||Grieshaber & Co. Ag Schaffhausen||Ophthalmological aspiration and irrigation system|
|US5368557 *||5 May 1993||29 Nov 1994||Baxter International Inc.||Ultrasonic ablation catheter device having multiple ultrasound transmission members|
|US5368558 *||3 Jun 1993||29 Nov 1994||Baxter International Inc.||Ultrasonic ablation catheter device having endoscopic component and method of using same|
|US5380274 *||12 Oct 1993||10 Jan 1995||Baxter International Inc.||Ultrasound transmission member having improved longitudinal transmission properties|
|US5382228 *||28 Sep 1993||17 Jan 1995||Baxter International Inc.||Method and device for connecting ultrasound transmission member (S) to an ultrasound generating device|
|US5382251 *||14 Feb 1992||17 Jan 1995||Biomet, Inc.||Plug pulling method|
|US5390678 *||12 Oct 1993||21 Feb 1995||Baxter International Inc.||Method and device for measuring ultrasonic activity in an ultrasound delivery system|
|US5395240 *||14 Sep 1993||7 Mar 1995||Dentsply Research & Development Corp.||Sterilizable dental medical handpiece containing electric coil|
|US5397301 *||19 Jul 1993||14 Mar 1995||Baxter International Inc.||Ultrasonic angioplasty device incorporating an ultrasound transmission member made at least partially from a superelastic metal alloy|
|US5405318 *||28 Sep 1993||11 Apr 1995||Baxter International Inc.||Ultra-sound catheter for removing obstructions from tubular anatomical structures such as blood vessels|
|US5413556 *||27 Aug 1993||9 May 1995||Inventive Systems, Inc.||Phacoemulsification handpiece|
|US5413578 *||14 Jun 1993||9 May 1995||Zahedi; Amir||Device for removing a bone cement tube|
|US5417654 *||2 Feb 1994||23 May 1995||Alcon Laboratories, Inc.||Elongated curved cavitation-generating tip for disintegrating tissue|
|US5417672 *||4 Oct 1993||23 May 1995||Baxter International Inc.||Connector for coupling an ultrasound transducer to an ultrasound catheter|
|US5427118 *||4 Oct 1993||27 Jun 1995||Baxter International Inc.||Ultrasonic guidewire|
|US5433702 *||16 Aug 1993||18 Jul 1995||Opthalmocare, Inc.||Phaco handpiece providing fingertip control of ultrasonic energy|
|US5443078 *||29 Jun 1994||22 Aug 1995||Interventional Technologies, Inc.||Method for advancing a guide wire|
|US5447509 *||4 Oct 1993||5 Sep 1995||Baxter International Inc.||Ultrasound catheter system having modulated output with feedback control|
|US5455766 *||13 Oct 1993||3 Oct 1995||Storz Instrument Company||Control system for ophthalmic surgical instruments|
|US5456686 *||25 Oct 1993||10 Oct 1995||Biomet, Inc.||Implantation and removal of orthopedic prostheses|
|US5474530 *||8 Jun 1994||12 Dec 1995||Baxter International Inc.||Angioplasty and ablative devices having onboard ultrasound components and devices and methods for utilizing ultrasound to treat or prevent vasospasm|
|US5492528 *||5 Dec 1994||20 Feb 1996||Anis; Azis Y.||Removal of tissue|
|US5524635 *||24 Oct 1994||11 Jun 1996||Interventional Technologies Inc.||Apparatus for advancing a guide wire|
|US5547454 *||2 Nov 1993||20 Aug 1996||Sandia Corporation||Ion-induced nuclear radiotherapy|
|US5562609 *||7 Oct 1994||8 Oct 1996||Fibrasonics, Inc.||Ultrasonic surgical probe|
|US5562610 *||7 Oct 1994||8 Oct 1996||Fibrasonics Inc.||Needle for ultrasonic surgical probe|
|US5616120 *||6 Feb 1995||1 Apr 1997||Andrew; Mark S.||Method and apparatus for lenticular liquefaction and aspiration|
|US5624394 *||28 Oct 1994||29 Apr 1997||Iolab Corporation||Vacuum system and a method of operating a vacuum system|
|US5667489 *||21 Feb 1995||16 Sep 1997||Kraff; Colman Ross||Expansile surgical sleeve apparatus and method for using same|
|US5676649 *||4 Oct 1996||14 Oct 1997||Alcon Laboratories, Inc.||Phacoemulsification cutting tip|
|US5702270 *||14 Dec 1995||30 Dec 1997||Alcon Laboratories, Inc.||Surgical handpiece holder|
|US5718676 *||7 Jun 1995||17 Feb 1998||Oversby Pty Ltd.||Grooved phaco-emulsification needle|
|US5722945 *||1 Apr 1996||3 Mar 1998||Aziz Yehia Anis||Removal of tissue|
|US5725570 *||29 Feb 1996||10 Mar 1998||Boston Scientific Corporation||Tubular medical endoprostheses|
|US5730718 *||29 Apr 1996||24 Mar 1998||Aziz Yehia Anis||Removal of tissue|
|US5733266 *||26 Jul 1996||31 Mar 1998||Gravlee, Jr.; Joseph F.||Hypodermic needle|
|US5769879 *||7 Jun 1995||23 Jun 1998||Medical Contouring Corporation||Microwave applicator and method of operation|
|US5775901 *||7 Mar 1996||7 Jul 1998||Hu-Friedy Mfg. Co., Ltd.||Insert for ultrasonic scaler|
|US5776155 *||23 Dec 1996||7 Jul 1998||Ethicon Endo-Surgery, Inc.||Methods and devices for attaching and detaching transmission components|
|US5788679 *||26 Jun 1996||4 Aug 1998||Gravlee, Jr.; Joseph F.||Phacoemulsification needle|
|US5795328 *||12 Jun 1996||18 Aug 1998||Iolab Corporation||Vacuum system and a method of operating a vacuum system|
|US5810766 *||28 Feb 1995||22 Sep 1998||Chiron Vision Corporation||Infusion/aspiration apparatus with removable cassette|
|US5810859 *||28 Feb 1997||22 Sep 1998||Ethicon Endo-Surgery, Inc.||Apparatus for applying torque to an ultrasonic transmission component|
|US5811909 *||10 Jan 1997||22 Sep 1998||Wuchinich; David G.||Superthermoelastic resonators|
|US5827292 *||12 Feb 1996||27 Oct 1998||Anis; Aziz Yehia||Removal of tissue|
|US5827297 *||30 Sep 1993||27 Oct 1998||Medicamat S.A.||Device for transplanting small diameter hair grafts|
|US5885243 *||11 Dec 1996||23 Mar 1999||Alcon Laboratories, Inc.||Liquefaction handpiece|
|US5921999 *||3 Jun 1997||13 Jul 1999||Dileo; Frank||System and method employing a pie-zoelectric crystal and transverse oscillation to perform a capsulotomy|
|US5935096 *||10 Jul 1997||10 Aug 1999||Oversby Pty Ltd.||Grooved phaco-emulsification needle|
|US5938633 *||9 Jul 1997||17 Aug 1999||Ethicon Endo-Surgery, Inc.||Ultrasonic surgical devices|
|US5938677 *||15 Oct 1997||17 Aug 1999||Alcon Laboratories, Inc.||Control system for a phacoemulsification handpiece|
|US5941887 *||3 Sep 1996||24 Aug 1999||Bausch & Lomb Surgical, Inc.||Sleeve for a surgical instrument|
|US5957943 *||5 Mar 1997||28 Sep 1999||Ethicon Endo-Surgery, Inc.||Method and devices for increasing ultrasonic effects|
|US5968060 *||28 Feb 1997||19 Oct 1999||Ethicon Endo-Surgery, Inc.||Ultrasonic interlock and method of using the same|
|US5984904 *||22 Aug 1996||16 Nov 1999||Bausch & Lomb Surgical, Inc.||Sleeve for a surgical instrument|
|US5989209 *||30 Jun 1997||23 Nov 1999||Oversby Pty Ltd.||Grooved phaco-emulsification needle|
|US5989212 *||6 Aug 1998||23 Nov 1999||Alcon Laboratories, Inc.||Pumping chamber for a liquefaction handpiece having a countersink electrode|
|US5989274 *||20 Dec 1996||23 Nov 1999||Ethicon Endo-Surgery, Inc.||Methods and devices for improving blood flow to a heart of a patient|
|US5989275 *||28 Feb 1997||23 Nov 1999||Ethicon Endo-Surgery, Inc.||Damping ultrasonic transmission components|
|US5993409 *||25 Nov 1997||30 Nov 1999||Surgin Surgical Instrumentation, Inc.||Needle for surgical use|
|US5997499 *||6 Aug 1998||7 Dec 1999||Alcon Laboratories, Inc.||Tip for a liquefaction handpiece|
|US6007513 *||5 Sep 1997||28 Dec 1999||Aziz Yehia Anis||Removal of tissue|
|US6013048 *||7 Nov 1997||11 Jan 2000||Mentor Corporation||Ultrasonic assisted liposuction system|
|US6024725 *||27 Nov 1996||15 Feb 2000||Mentor Corporation||Reducing tissue trauma and fluid loss during surgery|
|US6028387 *||29 Jun 1998||22 Feb 2000||Alcon Laboratories, Inc.||Ultrasonic handpiece tuning and controlling device|
|US6051010 *||23 Dec 1996||18 Apr 2000||Ethicon Endo-Surgery, Inc.||Methods and devices for joining transmission components|
|US6074358 *||25 Mar 1997||13 Jun 2000||Andrew; Mark S.||Method and apparatus for lenticular liquefaction and aspiration|
|US6077285 *||29 Jun 1998||20 Jun 2000||Alcon Laboratories, Inc.||Torsional ultrasound handpiece|
|US6080128 *||4 Jun 1998||27 Jun 2000||Alcon Laboratories, Inc.||Liquefaction handpiece|
|US6083191 *||9 Aug 1993||4 Jul 2000||Sherwood Services Ag||Ultrasonic surgical apparatus|
|US6083192 *||14 Feb 1997||4 Jul 2000||Bath; Patricia E.||Pulsed ultrasound method for fragmenting/emulsifying and removing cataractous lenses|
|US6110162 *||16 Aug 1999||29 Aug 2000||Alcon Laboratories, Inc.||Liquefaction handpiece|
|US6126668 *||24 Apr 1998||3 Oct 2000||Innovative Optics, Inc.||Microkeratome|
|US6139554 *||10 Jun 1999||31 Oct 2000||Karkar; Maurice N.||Multipurpose tissue resurfacing handpiece|
|US6156036 *||11 Jun 1999||5 Dec 2000||Alcon Laboratories, Inc.||Surgical handpiece tip|
|US6179805||28 Oct 1999||30 Jan 2001||Alcon Laboratories, Inc.||Liquefracture handpiece|
|US6179808||18 Jun 1999||30 Jan 2001||Alcon Laboratories, Inc.||Method of controlling the operating parameters of a surgical system|
|US6196989||28 Oct 1999||6 Mar 2001||Alcon Laboratories, Inc.||Tip for liquefracture handpiece|
|US6200326 *||28 Apr 1999||13 Mar 2001||Krishna Narayanan||Method and apparatus for hair removal using ultrasonic energy|
|US6208903||23 Jun 1998||27 Mar 2001||Medical Contouring Corporation||Microwave applicator|
|US6277084||5 May 1997||21 Aug 2001||Boston Scientific Corporation||Ultrasonic medical device|
|US6283974||14 Nov 1997||4 Sep 2001||Aaron James Alexander||Surgical tip for phacoemulsification|
|US6287274||17 Nov 1999||11 Sep 2001||Alcon Manufacturing, Inc.||Liquefaction handpiece|
|US6287331||12 May 1998||11 Sep 2001||Boston Scientific Corporation||Tubular medical prosthesis|
|US6290721||21 Oct 1997||18 Sep 2001||Boston Scientific Corporation||Tubular medical endoprostheses|
|US6315755||14 Dec 1999||13 Nov 2001||Alcon Manufacturing, Ltd.||Method of controlling a liquefracture handpiece|
|US6331171||1 Oct 1999||18 Dec 2001||Alcon Laboratories, Inc.||Tip for a liquefracture handpiece|
|US6340355||22 Aug 1997||22 Jan 2002||Graham David Barrett||Intraocular irrigation/aspiration device|
|US6352519||18 May 2000||5 Mar 2002||Aziz Yehia Anis||Removal of tissue|
|US6387109||3 Aug 1999||14 May 2002||Ethicon Endo-Surgery, Inc.||Methods and device for improving blood flow to heart of a patient|
|US6398759||17 Oct 2000||4 Jun 2002||Alcon Manufacturing, Ltd.||Liquefracture handpiece tip|
|US6402769||21 Jan 2000||11 Jun 2002||Alcon Universal Ltd.||Torsional ultrasound handpiece|
|US6419654 *||1 Feb 2000||16 Jul 2002||Jeffrey S. Kadan||Diagnostic needle arthroscopy and lavage system|
|US6425905||29 Nov 2000||30 Jul 2002||Med-Logics, Inc.||Method and apparatus for facilitating removal of a corneal graft|
|US6428508||1 Feb 2000||6 Aug 2002||Enlighten Technologies, Inc.||Pulsed vacuum cataract removal system|
|US6428510 *||12 May 2000||6 Aug 2002||Jeffrey S. Kadan||Diagnostic needle arthroscopy and lavage system|
|US6432078 *||19 Jun 2000||13 Aug 2002||Gholam A. Peyman||System and method for removing cataract or other cells in an eye using water jet and suction|
|US6491661||10 Nov 1999||10 Dec 2002||Alcon Manufacturing, Ltd.||Infusion control system|
|US6497709||5 May 1997||24 Dec 2002||Boston Scientific Corporation||Metal medical device|
|US6500157 *||3 Sep 1998||31 Dec 2002||Ronald B. Luther||Intravenous infusion needle with soft body|
|US6527802||23 Sep 1997||4 Mar 2003||Scimed Life Systems, Inc.||Clad composite stent|
|US6544211||26 Feb 1998||8 Apr 2003||Mark S. Andrew||Tissue liquefaction and aspiration|
|US6551337||19 Jul 2000||22 Apr 2003||Omnisonics Medical Technologies, Inc.||Ultrasonic medical device operating in a transverse mode|
|US6575929||14 Dec 2001||10 Jun 2003||Alcon Manufacturing, Ltd.||Pumping chamber for a liquefaction handpiece|
|US6579270||21 Feb 2002||17 Jun 2003||Alcon Manufacturing, Ltd.||Liquefracture handpiece tip|
|US6589201||14 Mar 2000||8 Jul 2003||Alcon Manufacturing, Ltd.||Liquefracture handpiece tip|
|US6589204||27 Jun 2000||8 Jul 2003||Alcon Manufacturing, Ltd.||Method of operating a liquefracture handpiece|
|US6648847||11 Feb 2003||18 Nov 2003||Alcon Manufacturing, Ltd.||Method of operating a liquefracture handpiece|
|US6660013||5 Oct 2001||9 Dec 2003||Omnisonics Medical Technologies, Inc.||Apparatus for removing plaque from blood vessels using ultrasonic energy|
|US6663644||2 Jun 2000||16 Dec 2003||Med-Logics, Inc.||Cutting blade assembly for a microkeratome|
|US6676628||22 Nov 1999||13 Jan 2004||Alcon Manufacturing, Ltd.||Pumping chamber for a liquefracture handpiece|
|US6676629||7 Apr 2003||13 Jan 2004||Mark S. Andrew||Tissue liquefaction and aspiration for dental treatment|
|US6689086||29 Jul 1999||10 Feb 2004||Advanced Cardiovascular Systems, Inc.||Method of using a catheter for delivery of ultrasonic energy and medicament|
|US6695782||11 Oct 2001||24 Feb 2004||Omnisonics Medical Technologies, Inc.||Ultrasonic probe device with rapid attachment and detachment means|
|US6699285||9 Feb 2001||2 Mar 2004||Scieran Technologies, Inc.||Eye endoplant for the reattachment of a retina|
|US6702832||15 Oct 2002||9 Mar 2004||Med Logics, Inc.||Medical device for cutting a cornea that has a vacuum ring with a slitted vacuum opening|
|US6716028||27 Jul 2001||6 Apr 2004||Hu-Friedy Mfg. Co., Inc.||Ultrasonic swivel insert|
|US6733451||25 Mar 2003||11 May 2004||Omnisonics Medical Technologies, Inc.||Apparatus and method for an ultrasonic probe used with a pharmacological agent|
|US6748944||3 May 2000||15 Jun 2004||Dellavecchia Michael Anthony||Ultrasonic dosage device and method|
|US6811399||4 Mar 2002||2 Nov 2004||Hu-Friedy Mfg. Co., Inc.||Torque lock for ultrasonic swivelable inserts and method|
|US6852093 *||10 May 2004||8 Feb 2005||Alcon, Inc.||Surgical method and apparatus|
|US6860868||29 Aug 2003||1 Mar 2005||Alcon Manufacturing, Ltd.||Surgical handpiece|
|US6863662||30 Dec 2002||8 Mar 2005||Ronald B. Luther||Intravenous infusion needle with soft body|
|US6866670||6 Aug 2003||15 Mar 2005||Omnisonics Medical Technologies, Inc.||Apparatus for removing plaque from blood vessels using ultrasonic energy|
|US6887083 *||16 Apr 2001||3 May 2005||Hideki Umeyama||Model for training of surgical operation of cataract|
|US6890390||22 May 2003||10 May 2005||Lawrence Azar||Method for ultrasonic cleaning using phased transducer arrays|
|US6908451||25 Apr 2002||21 Jun 2005||Alcon, Inc.||Liquid venting surgical system|
|US6921385||5 Aug 2002||26 Jul 2005||Alcon, Inc.||Apparatus for delivery of fluid to opthalmic surgical handpiece|
|US6929632||27 Jun 2002||16 Aug 2005||Advanced Cardiovascular Systems, Inc.||Ultrasonic devices and methods for ablating and removing obstructive matter from anatomical passageways and blood vessels|
|US6984220||11 Apr 2001||10 Jan 2006||Wuchinich David G||Longitudinal-torsional ultrasonic tissue dissection|
|US7011520||17 Jan 2003||14 Mar 2006||Hu-Friedy Mfg. Co., Inc.||Two part ultrasonic swivel insert, with one part rotatable relative to the other|
|US7011644||7 Jan 2004||14 Mar 2006||Andrew Mark S||Tissue liquefaction and aspiration for dental treatment|
|US7041078||27 Jan 2003||9 May 2006||Peyman Gholam A||System and method for removing cataract or other cells in an eye using water jet and suction|
|US7044948||4 Dec 2003||16 May 2006||Sherwood Services Ag||Circuit for controlling arc energy from an electrosurgical generator|
|US7083589 *||13 Dec 2001||1 Aug 2006||Surgical Design Corporation||Ultrasonic instrument with coupler for work tip|
|US7101392||8 Aug 2001||5 Sep 2006||Boston Scientific Corporation||Tubular medical endoprostheses|
|US7131860||20 Nov 2003||7 Nov 2006||Sherwood Services Ag||Connector systems for electrosurgical generator|
|US7137980||1 May 2003||21 Nov 2006||Sherwood Services Ag||Method and system for controlling output of RF medical generator|
|US7160268||5 Aug 2002||9 Jan 2007||Alcon, Inc.||Container for delivery of fluid to ophthalmic surgical handpiece|
|US7255694||4 Dec 2003||14 Aug 2007||Sherwood Services Ag||Variable output crest factor electrosurgical generator|
|US7276060||26 Feb 2004||2 Oct 2007||Alcon, Inc.||Surgical handpiece tip|
|US7297137||5 Apr 2004||20 Nov 2007||Alcon, Inc.||Method of detecting surgical events|
|US7300435||21 Nov 2003||27 Nov 2007||Sherwood Services Ag||Automatic control system for an electrosurgical generator|
|US7303557||27 Dec 2004||4 Dec 2007||Sherwood Services Ag||Vessel sealing system|
|US7311700||29 Nov 2000||25 Dec 2007||Med-Logics, Inc.||LASIK laminar flow system|
|US7314470||11 Sep 2001||1 Jan 2008||Wolfgang Malodobry||Scar-free removal of tattoos|
|US7364577||24 Jul 2003||29 Apr 2008||Sherwood Services Ag||Vessel sealing system|
|US7374552 *||3 Aug 2005||20 May 2008||Wuchinich David G||Longitudinal-torsional ultrasonic tissue dissection|
|US7396336||27 Oct 2004||8 Jul 2008||Sherwood Services Ag||Switched resonant ultrasonic power amplifier system|
|US7416437||23 Aug 2006||26 Aug 2008||Sherwood Services Ag||Connector systems for electrosurgical generator|
|US7494468||21 Feb 2003||24 Feb 2009||Omnisonics Medical Technologies, Inc.||Ultrasonic medical device operating in a transverse mode|
|US7503895||24 Feb 2003||17 Mar 2009||Omnisonics Medical Technologies, Inc.||Ultrasonic device for tissue ablation and sheath for use therewith|
|US7513896||24 Jan 2006||7 Apr 2009||Covidien Ag||Dual synchro-resonant electrosurgical apparatus with bi-directional magnetic coupling|
|US7540870||27 Aug 2007||2 Jun 2009||Bacoustics, Llc||Ablative ultrasonic-cryogenic apparatus|
|US7544177||24 Jan 2003||9 Jun 2009||The Regents Of The University Of California||Aerosol device to deliver bioactive agent|
|US7572242||19 Aug 2005||11 Aug 2009||Alcon, Inc.||Method of operating an ultrasound handpiece|
|US7572268||13 Oct 2005||11 Aug 2009||Bacoustics, Llc||Apparatus and methods for the selective removal of tissue using combinations of ultrasonic energy and cryogenic energy|
|US7625388||1 Dec 2009||Alcon, Inc.||Method of controlling a surgical system based on a load on the cutting tip of a handpiece|
|US7628786||16 May 2005||8 Dec 2009||Covidien Ag||Universal foot switch contact port|
|US7637907||19 Sep 2006||29 Dec 2009||Covidien Ag||System and method for return electrode monitoring|
|US7640119||30 Jun 2006||29 Dec 2009||Alcon, Inc.||System for dynamically adjusting operation of a surgical handpiece|
|US7644603||12 Jan 2010||Alcon, Inc.||Method of testing a surgical system|
|US7645255||12 Jan 2010||Alcon, Inc.||Method of controlling a surgical system based on irrigation flow|
|US7645256||12 Jan 2010||Alcon, Inc.||Ultrasound handpiece|
|US7648465||28 Jun 2005||19 Jan 2010||Alcon, Inc.||Method of testing a surgical system|
|US7648499||21 Mar 2006||19 Jan 2010||Covidien Ag||System and method for generating radio frequency energy|
|US7651490||26 Jan 2010||Alcon, Inc.||Ultrasonic handpiece|
|US7651492||26 Jan 2010||Covidien Ag||Arc based adaptive control system for an electrosurgical unit|
|US7651493||26 Jan 2010||Covidien Ag||System and method for controlling electrosurgical snares|
|US7695447||13 Apr 2010||Alcon, Inc.||Apparatus and method for determining that a surgical fluid container is near empty|
|US7708734||30 Jun 2006||4 May 2010||Alcon, Inc.||Method for dynamically adjusting operation of a surgical handpiece|
|US7713202||26 Jul 2005||11 May 2010||Alcon, Inc.||Method of controlling a surgical system based on a load on the cutting tip of a handpiece|
|US7722601||30 Apr 2004||25 May 2010||Covidien Ag||Method and system for programming and controlling an electrosurgical generator system|
|US7727193||26 Jul 2005||1 Jun 2010||Alcon, Inc.||Method of controlling a surgical system based on a rate of change of an operating parameter|
|US7731717||8 Aug 2006||8 Jun 2010||Covidien Ag||System and method for controlling RF output during tissue sealing|
|US7736329||9 Nov 2006||15 Jun 2010||Dodick Jack M||Surgical instrument with a sleeve for use during eye surgery|
|US7749217||6 May 2003||6 Jul 2010||Covidien Ag||Method and system for optically detecting blood and controlling a generator during electrosurgery|
|US7758538||26 Jul 2005||20 Jul 2010||Alcon, Inc.||Method of controlling a surgical system based on irrigation flow|
|US7758585||20 Jul 2010||Alcon, Inc.||Pumping chamber for a liquefaction handpiece|
|US7762979||26 Nov 2007||27 Jul 2010||Wuchinich David G||Longitudinal-torsional ultrasonic tissue dissection|
|US7766693||3 Aug 2010||Covidien Ag||Connector systems for electrosurgical generator|
|US7766905||3 Aug 2010||Covidien Ag||Method and system for continuity testing of medical electrodes|
|US7776027 *||11 Jul 2002||17 Aug 2010||Misonix, Incorporated||Medical handpiece with automatic power switching means|
|US7780659 *||24 Aug 2010||Olympus Corporation||Ultrasound treatment system|
|US7780662||24 Aug 2010||Covidien Ag||Vessel sealing system using capacitive RF dielectric heating|
|US7794414||9 Feb 2004||14 Sep 2010||Emigrant Bank, N.A.||Apparatus and method for an ultrasonic medical device operating in torsional and transverse modes|
|US7794457||28 Sep 2006||14 Sep 2010||Covidien Ag||Transformer for RF voltage sensing|
|US7803168||28 Sep 2010||The Foundry, Llc||Aortic valve repair|
|US7806865||20 May 2009||5 Oct 2010||Alcon Research, Ltd.||Pressurized irrigation squeeze band|
|US7811255||12 Oct 2010||Alcon, Inc.||Method of controlling a surgical system based on a rate of change of an operating parameter|
|US7824400||3 Mar 2006||2 Nov 2010||Covidien Ag||Circuit for controlling arc energy from an electrosurgical generator|
|US7834484||16 Nov 2010||Tyco Healthcare Group Lp||Connection cable and method for activating a voltage-controlled generator|
|US7842032||18 Apr 2007||30 Nov 2010||Bacoustics, Llc||Apparatus and methods for the selective removal of tissue|
|US7849875||31 Jul 2007||14 Dec 2010||Alcon, Inc.||Check valve|
|US7857794||14 Jun 2004||28 Dec 2010||Alcon, Inc.||Handpiece tip|
|US7901400||8 Mar 2011||Covidien Ag||Method and system for controlling output of RF medical generator|
|US7927328||24 Jan 2007||19 Apr 2011||Covidien Ag||System and method for closed loop monitoring of monopolar electrosurgical apparatus|
|US7947009 *||24 May 2011||Carl Zeiss Surgical Gmbh||Surgical system and method for controlling fluid when treating a cataract with the phacoemulsification technique|
|US7947039||12 Dec 2005||24 May 2011||Covidien Ag||Laparoscopic apparatus for performing electrosurgical procedures|
|US7967775||28 Jun 2011||Alcon, Inc.||Irrigation/aspiration tip|
|US7967799||28 Jun 2011||Alcon, Inc.||Liquefaction handpiece tip|
|US7972328||24 Jan 2007||5 Jul 2011||Covidien Ag||System and method for tissue sealing|
|US7972332||5 Jul 2011||Covidien Ag||System and method for controlling electrosurgical snares|
|US7981074||19 Jul 2011||Novartis Ag||Irrigation/aspiration system|
|US8012150||30 Apr 2004||6 Sep 2011||Covidien Ag||Method and system for programming and controlling an electrosurgical generator system|
|US8016843||13 Sep 2011||Alcon Research Ltd||Ultrasonic knife|
|US8025660||27 Sep 2011||Covidien Ag||Universal foot switch contact port|
|US8034049||8 Aug 2006||11 Oct 2011||Covidien Ag||System and method for measuring initial tissue impedance|
|US8043088 *||25 Oct 2011||Johnson Douglas B||Endodontic procedure employing simultaneous liquefaction and acoustic debridgement|
|US8048020||1 Nov 2011||Alcon, Inc.||Method of controlling a surgical system based on irrigation flow|
|US8062289||24 Apr 2009||22 Nov 2011||Bacoustics, Llc||Ablative ultrasonic-cryogenic apparatus|
|US8070711||9 Dec 2009||6 Dec 2011||Alcon Research, Ltd.||Thermal management algorithm for phacoemulsification system|
|US8080008||20 Dec 2011||Covidien Ag||Method and system for programming and controlling an electrosurgical generator system|
|US8096961||27 Jun 2008||17 Jan 2012||Covidien Ag||Switched resonant ultrasonic power amplifier system|
|US8104956||23 Oct 2003||31 Jan 2012||Covidien Ag||Thermocouple measurement circuit|
|US8105323||24 Oct 2006||31 Jan 2012||Covidien Ag||Method and system for controlling output of RF medical generator|
|US8113057||27 Jun 2008||14 Feb 2012||Covidien Ag||Switched resonant ultrasonic power amplifier system|
|US8118777||26 May 2010||21 Feb 2012||Cook Medical Technologies Llc||Systems and methods for delivering therapeutic agents|
|US8136779||27 Jul 2010||20 Mar 2012||Alcon Research, Ltd.||Mounting arrangement for a pressurized irrigation system|
|US8147485||23 Feb 2009||3 Apr 2012||Covidien Ag||System and method for tissue sealing|
|US8157792 *||17 Apr 2012||Haemonetics Corporation||Wound drainage suction relief|
|US8172786||8 May 2012||Alcon Research, Ltd.||Method of operating an ultrasound handpiece|
|US8187168||7 Jul 2008||29 May 2012||David George Wuchinich||Retractable ultrasonic endoscopic aspirator|
|US8187262||3 Jun 2009||29 May 2012||Covidien Ag||Dual synchro-resonant electrosurgical apparatus with bi-directional magnetic coupling|
|US8202271||25 Feb 2009||19 Jun 2012||Covidien Ag||Dual synchro-resonant electrosurgical apparatus with bi-directional magnetic coupling|
|US8216220||10 Jul 2012||Tyco Healthcare Group Lp||System and method for transmission of combined data stream|
|US8216223||10 Jul 2012||Covidien Ag||System and method for tissue sealing|
|US8226639||24 Jul 2012||Tyco Healthcare Group Lp||System and method for output control of electrosurgical generator|
|US8231616||31 Jul 2012||Covidien Ag||Transformer for RF voltage sensing|
|US8241278||14 Aug 2012||Covidien Ag||Laparoscopic apparatus for performing electrosurgical procedures|
|US8257307||12 Oct 2009||4 Sep 2012||Alcon Research, Ltd.||Method of controlling a surgical system based on a load on the cutting tip of a handpiece|
|US8267928||29 Mar 2011||18 Sep 2012||Covidien Ag||System and method for closed loop monitoring of monopolar electrosurgical apparatus|
|US8267929||16 Dec 2011||18 Sep 2012||Covidien Ag||Method and system for programming and controlling an electrosurgical generator system|
|US8287528||28 Mar 2008||16 Oct 2012||Covidien Ag||Vessel sealing system|
|US8291933||23 Oct 2012||Novartis Ag||Spring-less check valve for a handpiece|
|US8298223||30 Oct 2012||Covidien Ag||Method and system for programming and controlling an electrosurgical generator system|
|US8303530||6 Nov 2012||Novartis Ag||Method of operating an ultrasound handpiece|
|US8303580||5 Apr 2010||6 Nov 2012||Covidien Ag||Method and system for programming and controlling an electrosurgical generator system|
|US8308735||6 Oct 2008||13 Nov 2012||Novartis Ag||Phacoemulsification tip with internal oriented structures|
|US8353297||31 Aug 2005||15 Jan 2013||Novartis Ag||Pulse manipulation for controlling a phacoemulsification surgical system|
|US8353905||18 Jun 2012||15 Jan 2013||Covidien Lp||System and method for transmission of combined data stream|
|US8361054||8 Dec 2009||29 Jan 2013||Cook Medical Technologies Llc||Apparatus and methods for containing and delivering therapeutic agents|
|US8403851||26 Mar 2013||Novartis Ag||Method of controlling a surgical system based on a load on the cutting tip of a handpiece|
|US8403951||26 Mar 2013||Novartis Ag||Phacoemulsification tip|
|US8414605||8 Jul 2011||9 Apr 2013||Alcon Research, Ltd.||Vacuum level control of power for phacoemulsification hand piece|
|US8430838||6 Jan 2010||30 Apr 2013||Novartis Ag||Method of controlling a surgical system based on irrigation flow|
|US8465467||18 Jun 2013||Novartis Ag||Method of controlling an irrigation/aspiration system|
|US8475447||23 Aug 2012||2 Jul 2013||Covidien Ag||System and method for closed loop monitoring of monopolar electrosurgical apparatus|
|US8480661||27 Mar 2010||9 Jul 2013||Carl Zeiss Meditec Ag||Apparatus and method for removing a lenticle from the cornea|
|US8485993||16 Jan 2012||16 Jul 2013||Covidien Ag||Switched resonant ultrasonic power amplifier system|
|US8486061||24 Aug 2012||16 Jul 2013||Covidien Lp||Imaginary impedance process monitoring and intelligent shut-off|
|US8487487||13 Jul 2009||16 Jul 2013||Ethicon Endo-Surgery, Inc.||Magnetostrictive actuator of a medical ultrasound transducer assembly, and a medical ultrasound handpiece and a medical ultrasound system having such actuator|
|US8512332||21 Sep 2007||20 Aug 2013||Covidien Lp||Real-time arc control in electrosurgical generators|
|US8523812||3 Sep 2010||3 Sep 2013||Alcon Research, Ltd.||Method of controlling a surgical system based on a rate of change of an operating parameter|
|US8523855||23 Aug 2010||3 Sep 2013||Covidien Ag||Circuit for controlling arc energy from an electrosurgical generator|
|US8556890||14 Dec 2009||15 Oct 2013||Covidien Ag||Arc based adaptive control system for an electrosurgical unit|
|US8568422||28 Aug 2009||29 Oct 2013||Nigel Morlet||Cutting needle tip for surgical instrument|
|US8574228||30 Jun 2010||5 Nov 2013||Olympus Corporation||Ultrasound treatment system|
|US8579929||3 Sep 2010||12 Nov 2013||Alcon Research, Ltd.||Torsional ultrasound hand piece that eliminates chatter|
|US8623040||1 Jul 2009||7 Jan 2014||Alcon Research, Ltd.||Phacoemulsification hook tip|
|US8631831||12 Aug 2009||21 Jan 2014||Alcon Research, Ltd.||Multi-compliant tubing|
|US8647340||4 Jan 2012||11 Feb 2014||Covidien Ag||Thermocouple measurement system|
|US8663214||24 Jan 2007||4 Mar 2014||Covidien Ag||Method and system for controlling an output of a radio-frequency medical generator having an impedance based control algorithm|
|US8672935||30 Jun 2010||18 Mar 2014||Olympus Corporation||Ultrasound treatment system|
|US8685016||23 Feb 2009||1 Apr 2014||Covidien Ag||System and method for tissue sealing|
|US8728032||17 Jan 2012||20 May 2014||Cook Medical Technologies Llc||Systems and methods for delivering therapeutic agents|
|US8734438||21 Oct 2005||27 May 2014||Covidien Ag||Circuit and method for reducing stored energy in an electrosurgical generator|
|US8753334||10 May 2006||17 Jun 2014||Covidien Ag||System and method for reducing leakage current in an electrosurgical generator|
|US8771301||11 Sep 2009||8 Jul 2014||Alcon Research, Ltd.||Ultrasonic handpiece|
|US8777941||10 May 2007||15 Jul 2014||Covidien Lp||Adjustable impedance electrosurgical electrodes|
|US8784357||15 Sep 2010||22 Jul 2014||Alcon Research, Ltd.||Phacoemulsification hand piece with two independent transducers|
|US8790359||18 May 2007||29 Jul 2014||Cybersonics, Inc.||Medical systems and related methods|
|US8808161||23 Oct 2003||19 Aug 2014||Covidien Ag||Redundant temperature monitoring in electrosurgical systems for safety mitigation|
|US8814894||11 Sep 2009||26 Aug 2014||Novartis Ag||Ultrasound handpiece|
|US8852091||4 Apr 2012||7 Oct 2014||Alcon Research, Ltd.||Devices, systems, and methods for pupil expansion|
|US8876745||23 Mar 2009||4 Nov 2014||Alcon Research Ltd.||Streamlined ultrasonic device and method of use|
|US8882792||16 Aug 2010||11 Nov 2014||Ethicon Endo-Surgery, Inc.||Ultrasonic surgical apparatus with silicon waveguide|
|US8939927||12 Dec 2011||27 Jan 2015||Alcon Research, Ltd.||Systems and methods for small bore aspiration|
|US8966981||16 Jul 2013||3 Mar 2015||Covidien Ag||Switched resonant ultrasonic power amplifier system|
|US8974412||3 Aug 2012||10 Mar 2015||Novartis Ag||Method of controlling a surgical system based on a load on the cutting tip of a handpiece|
|US9034032||19 Jul 2013||19 May 2015||Twelve, Inc.||Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods|
|US9034033||19 Jul 2013||19 May 2015||Twelve, Inc.||Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods|
|US9039757||15 Mar 2013||26 May 2015||Twelve, Inc.||Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods|
|US9050171 *||12 May 2011||9 Jun 2015||William J. Foster||Small diameter fragmatome for minimally traumatic retained lens fragments removal|
|US9066690||17 Sep 2008||30 Jun 2015||Covidien Lp||Blood collection needle assembly|
|US9101744||21 Dec 2012||11 Aug 2015||Cook Medical Technologies Llc||Systems and methods for delivering therapeutic agents|
|US9113900||31 Jan 2012||25 Aug 2015||Covidien Ag||Method and system for controlling output of RF medical generator|
|US9114245||16 Aug 2010||25 Aug 2015||Ethicon Endo-Surgery, Inc.||Ultrasonic surgical apparatus and methods for use thereof|
|US9119624||8 Oct 2013||1 Sep 2015||Covidien Ag||ARC based adaptive control system for an electrosurgical unit|
|US9125740||23 Jul 2013||8 Sep 2015||Twelve, Inc.||Prosthetic heart valve devices and associated systems and methods|
|US9126219||6 Sep 2013||8 Sep 2015||Alcon Research, Ltd.||Acoustic streaming fluid ejector|
|US9132229||13 Sep 2012||15 Sep 2015||Alcon Research, Ltd.||System and method of priming a surgical cassette|
|US9149291||11 Jun 2012||6 Oct 2015||Tenex Health, Inc.||Systems and methods for tissue treatment|
|US9149387||4 Sep 2008||6 Oct 2015||Novartis Ag||Varying material properties of a single fluidic line in ophthalmology tubing|
|US9168089||31 Jan 2012||27 Oct 2015||Covidien Ag||Method and system for controlling output of RF medical generator|
|US9186200||30 May 2012||17 Nov 2015||Covidien Ag||System and method for tissue sealing|
|US9233021||24 Oct 2013||12 Jan 2016||Alcon Research, Ltd.||Phacoemulsification hook tip|
|US9271790||20 Aug 2013||1 Mar 2016||Coviden Lp||Real-time arc control in electrosurgical generators|
|US9282989||31 Oct 2012||15 Mar 2016||Novartis Ag||Method of controlling a surgical system based on a load on the cutting tip of a handpiece|
|US9295552||20 Feb 2015||29 Mar 2016||Twelve, Inc.||Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods|
|US20010047166 *||11 Apr 2001||29 Nov 2001||Wuchinich David G.||Longitudinal-torsional ultrasonic tissue Dissection|
|US20020028429 *||16 Apr 2001||7 Mar 2002||Hideki Umeyama||Model for training of surgical operation of cataract|
|US20030009125 *||27 Jun 2002||9 Jan 2003||Henry Nita||Ultrasonic devices and methods for ablating and removing obstructive matter from anatomical passageways and blood vessels|
|US20030065263 *||10 Oct 2002||3 Apr 2003||Omnisonics Medical Technologies, Inc.||Ultrasonic probe device with rapid attachment and detachment means having a line contact collet|
|US20030114873 *||13 Dec 2001||19 Jun 2003||Surgical Design Corporation||Ultrasonic instrument with coupler for work tip|
|US20030125645 *||21 Feb 2003||3 Jul 2003||Omnisonics Medical Technologies, Inc.||Ultrasonic medical device operating in a transverse mode|
|US20030181917 *||24 Jan 2003||25 Sep 2003||The Regents Of The University Of California||Aerosol device to deliver bioactive agent|
|US20030204166 *||25 Apr 2002||30 Oct 2003||Sorensen Gary P.||Liquid venting surgical cassette|
|US20030225366 *||7 May 2003||4 Dec 2003||Morgan Michael D.||Liquid venting surgical cassette|
|US20030236539 *||25 Mar 2003||25 Dec 2003||Omnisonics Medical Technologies, Inc.||Apparatus and method for using an ultrasonic probe to clear a vascular access device|
|US20040010250 *||11 Jul 2002||15 Jan 2004||Ronald R. Manna||Medical handpiece with automatic power switching means|
|US20040024380 *||5 Aug 2002||5 Feb 2004||Darnell Lawrence W.||Container for delivery of fluid to ophthalmic surgical handpiece|
|US20040030254 *||23 May 2003||12 Feb 2004||Eilaz Babaev||Device and method for ultrasound wound debridement|
|US20040073244 *||6 Aug 2003||15 Apr 2004||Omnisonics Medical Technologies, Inc.||Method and apparatus for removing plaque from blood vessels using ultrasonic energy|
|US20040097996 *||19 Sep 2003||20 May 2004||Omnisonics Medical Technologies, Inc.||Apparatus and method of removing occlusions using an ultrasonic medical device operating in a transverse mode|
|US20040111107 *||11 Sep 2001||10 Jun 2004||Wolfgang Malodobry||Scar-free removal of tatoos|
|US20040158151 *||4 Feb 2004||12 Aug 2004||Omnisonics Medical Technologies, Inc.||Apparatus and method for an ultrasonic probe device with rapid attachment and detachment means|
|US20040191724 *||5 Apr 2004||30 Sep 2004||Rahman Anisur Mithu||Ultrasonic swivel insert|
|US20040231697 *||22 May 2003||25 Nov 2004||Lawrence Azar||Systems and methods for ultrasonic cleaning using phased transducer arrays|
|US20040249401 *||14 May 2004||9 Dec 2004||Omnisonics Medical Technologies, Inc.||Apparatus and method for an ultrasonic medical device with a non-compliant balloon|
|US20040253129 *||15 Jul 2004||16 Dec 2004||Sorensen Gary P.||Liquid venting surgical cassette|
|US20050004589 *||29 Aug 2003||6 Jan 2005||Olympus Optical Co., Ld.||Ultrasound treatment system|
|US20050043629 *||6 Oct 2004||24 Feb 2005||Omnisonics Medical Technologies, Inc.||Apparatus and method for an ultrasonic medical device having a probe with a small proximal end|
|US20050043753 *||7 Oct 2004||24 Feb 2005||Omnisonics Medical Technologies, Inc.||Apparatus and method for an ultrasonic medical device to treat peripheral artery disease|
|US20050096669 *||28 Oct 2004||5 May 2005||Omnisonics Medical Technologies, Inc.||Apparatus and method for an ultrasonic medical device to treat coronary thrombus bearing lesions|
|US20050119679 *||28 Oct 2004||2 Jun 2005||Omnisonics Medical Technologies, Inc.||Apparatus and method for an ultrasonic medical device to treat chronic total occlusions|
|US20050192548 *||26 Feb 2004||1 Sep 2005||Dolliver Phillip B.||Wound drainage suction relief|
|US20050192566 *||26 Feb 2004||1 Sep 2005||Madden Sean C.||Surgical handpiece tip|
|US20050209560 *||28 Feb 2005||22 Sep 2005||Alcon, Inc.||Method of controlling a surgical system based on a rate of change of an operating parameter|
|US20050209561 *||5 Apr 2004||22 Sep 2005||Raphael Gordon||Method of detecting surgical events|
|US20050228423 *||8 Jun 2005||13 Oct 2005||Alcon, Inc.||Apparatus and method for determining that a surgical fluid container is near empty|
|US20050228424 *||8 Jun 2005||13 Oct 2005||Alcon, Inc.||Apparatus and method for determining that a surgical fluid container is near empty|
|US20050228425 *||28 Feb 2005||13 Oct 2005||Alcon, Inc.||Method of controlling a surgical system based on a load on the cutting tip of a handpiece|
|US20050251105 *||12 Jul 2005||10 Nov 2005||Peyman Gholam A||System and method for removing cataract or other cells in an eye using water jet and suction|
|US20050261628 *||26 Jul 2005||24 Nov 2005||Alcon, Inc.||Method of controlling a surgical system based on a rate of change of an operating parameter|
|US20050261715 *||26 Jul 2005||24 Nov 2005||Alcon, Inc.||Method of controlling a surgical system based on a load on the cutting tip of a handpiece|
|US20050264139 *||3 Aug 2005||1 Dec 2005||Wuchinich David G||Longitudinal-torsional ultrasonic tissue dissection|
|US20050267504 *||26 Jul 2005||1 Dec 2005||Alcon, Inc.||Method of controlling a surgical system based on irrigation flow|
|US20050277869 *||19 Aug 2005||15 Dec 2005||Alcon, Inc.||Method of operating an ultrasound handpiece|
|US20060002982 *||3 May 2005||5 Jan 2006||Bausch & Lomb Incorporated||Xanthan gum viscoelastic composition, method of use and package|
|US20060036180 *||12 Aug 2004||16 Feb 2006||Mikhail Boukhny||Ultrasonic handpiece|
|US20060041220 *||18 Jul 2005||23 Feb 2006||Alcon, Inc.||Ultrasound handpiece|
|US20060073184 *||21 Jun 2005||6 Apr 2006||Bausch & Lomb Inc.||Viscoelastic composition, methods of use and packaging device with anti-oxidant|
|US20060084937 *||14 Oct 2004||20 Apr 2006||Takayuki Akahoshi||Low resistance irrigation system|
|US20060189948 *||18 Feb 2005||24 Aug 2006||Alcon, Inc.||Phacoemulsification tip|
|US20060190003 *||21 Sep 2005||24 Aug 2006||Alcon, Inc.||Surgical method|
|US20060206050 *||8 Mar 2005||14 Sep 2006||Alcon, Inc.||Phacoemulsification tip|
|US20060212037 *||16 Mar 2005||21 Sep 2006||Alcon, Inc.||Pumping chamber for a liquefaction handpiece|
|US20060212038 *||16 Mar 2005||21 Sep 2006||Alcon, Inc.||Liquefaction handpiece tip|
|US20060212039 *||16 Mar 2005||21 Sep 2006||Alcon, Inc.||Pumping chamber for a liquefaction handpiece|
|US20060217672 *||8 Mar 2005||28 Sep 2006||Alcon, Inc.||Phacoemulsification tip|
|US20060217739 *||22 Mar 2005||28 Sep 2006||Alcon, Inc.||Phacoemulsification tip|
|US20060224116 *||16 Mar 2005||5 Oct 2006||Alcon, Inc.||Pumping chamber for a liquefaction handpiece|
|US20060229659 *||9 Dec 2005||12 Oct 2006||The Foundry, Inc.||Aortic valve repair|
|US20060253062 *||26 Apr 2005||9 Nov 2006||Alcon, Inc.||Low resistance irrigation system and apparatus|
|US20060264896 *||9 May 2005||23 Nov 2006||Palmer Erika I||Minimally invasive apparatus and method for treatment of a tumor associated with a bone|
|US20060264970 *||19 May 2005||23 Nov 2006||Alcon, Inc.||Phacoemulsification tip|
|US20070000301 *||21 Jun 2005||4 Jan 2007||Todd Kirk W||Reflux control in microsurgical system|
|US20070010730 *||28 Jun 2005||11 Jan 2007||Alcon, Inc.||Method of testing a surgical system|
|US20070027470 *||30 Jun 2006||1 Feb 2007||Dodick Jack M||Surgical instrument|
|US20070056596 *||31 Aug 2005||15 Mar 2007||Alcon, Inc.||Pulse manipulation for controlling a phacoemulsification surgical system|
|US20070060926 *||7 Aug 2006||15 Mar 2007||Escaf Luis J||Ultrasonic knife|
|US20070073214 *||31 Aug 2005||29 Mar 2007||Alcon, Inc.||Pulse manipulation for controlling a phacoemulsification surgical system|
|US20070078379 *||31 Aug 2005||5 Apr 2007||Alcon, Inc.||Controlling a phacoemulsification surgical system by transitioning between pulse and burst modes|
|US20070088217 *||13 Oct 2005||19 Apr 2007||Babaev Eilaz P||Apparatus and methods for the selective removal of tissue using combinations of ultrasonic energy and cryogenic energy|
|US20070088386 *||18 Oct 2005||19 Apr 2007||Babaev Eilaz P||Apparatus and method for treatment of soft tissue injuries|
|US20070106303 *||9 Nov 2006||10 May 2007||Dodick Jack M||Surgical instrument|
|US20070135760 *||14 Dec 2005||14 Jun 2007||Williams David L||Occlusion clearance in microsurgical system|
|US20070179438 *||30 Jan 2006||2 Aug 2007||Alcon, Inc.||Surge suppression method|
|US20070255196 *||11 Dec 2006||1 Nov 2007||Wuchinich David G||Ultrasonic liquefaction method and apparatus using a tapered ultrasonic tip|
|US20080006096 *||27 Jun 2005||10 Jan 2008||Alcon, Inc.||Method of testing a surgical system|
|US20080039745 *||27 Aug 2007||14 Feb 2008||Bacoustics Llc||Ablative ultrasonic-cryogenic apparatus|
|US20080058845 *||10 Jun 2005||6 Mar 2008||Koh Shimizu||Ultrasonic Surgical Operation Instrument|
|US20080082040 *||10 Sep 2007||3 Apr 2008||Christoph Kubler||Surgical system|
|US20080103418 *||26 Nov 2007||1 May 2008||Wuchinich David G||Longitudinal-torsional ultrasonic tissue dissection|
|US20080122407 *||30 Jun 2006||29 May 2008||Alcon, Inc.||System for dynamically adjusting operation of a surgical handpiece|
|US20080125695 *||23 Jun 2006||29 May 2008||Hopkins Mark A||Reflux control in microsurgical system|
|US20080125697 *||14 Sep 2006||29 May 2008||Alcon, Inc.||Method of controlling an irrigation/aspiration system|
|US20080125699 *||2 Nov 2006||29 May 2008||Alcon, Inc.||Irrigation/aspiration system|
|US20080167604 *||9 Jan 2007||10 Jul 2008||Alcon, Inc.||Irrigation/Aspiration Tip|
|US20080172076 *||1 Nov 2006||17 Jul 2008||Alcon, Inc.||Ultrasound apparatus and method of use|
|US20080188792 *||24 Mar 2005||7 Aug 2008||Graham David Barrett||Phacoemulsification Needle|
|US20080281253 *||10 May 2007||13 Nov 2008||Injev Valentine P||Method of Operating an Ultrasound Handpiece|
|US20080306501 *||12 Aug 2008||11 Dec 2008||Celleration, Inc.||Device and method for ultrasound wound debridement|
|US20090018488 *||9 Jul 2007||15 Jan 2009||Davis Sherman G||Method of Priming a Surgical System|
|US20090018490 *||7 Jul 2008||15 Jan 2009||David George Wuchinich||Retractable ultrasonic endoscopic aspirator|
|US20090032121 *||31 Jul 2007||5 Feb 2009||Chon James Y||Check Valve|
|US20090032123 *||31 Jul 2007||5 Feb 2009||Bourne John M||Check Valve|
|US20090042163 *||21 Oct 2008||12 Feb 2009||Johnson Douglas B||Endodontic Procedure Employing Simultaneous Liquefaction and Acoustic Debridgement|
|US20090088698 *||17 Sep 2008||2 Apr 2009||Tyco Healthcare Group Lp||Blood Collection Needle Assembly|
|US20090124962 *||16 Jan 2009||14 May 2009||Hopkins Mark A||Reflux control in microsurgical system|
|US20090209885 *||24 Apr 2009||20 Aug 2009||Bacoustics, Llc||Ablative ultrasonic-cryogenic apparatus|
|US20090221955 *||14 May 2009||3 Sep 2009||Bacoustics, Llc||Ablative ultrasonic-cryogenic methods|
|US20090247936 *||23 Mar 2009||1 Oct 2009||Alcon Research Ltd.||Streamlined ultrasonic device and method of use|
|US20090306583 *||10 Dec 2009||Mikhail Boukhny||Method of Operating An Ultrasound Handpiece|
|US20100004585 *||11 Sep 2009||7 Jan 2010||Mikhail Boukhny||Ultrasonic Handpiece|
|US20100016728 *||13 Jul 2009||21 Jan 2010||Dietz Timothy G||Magnetostrictive actuator of a medical ultrasound transducer assembly, and a medical ultrasound handpiece and a medical ultrasound system having such actuator|
|US20100036256 *||11 Feb 2010||Mikhail Boukhny||Offset ultrasonic hand piece|
|US20100036387 *||19 Oct 2009||11 Feb 2010||Claudio Bucolo||Viscoelastic Composition for Surgical Procedures|
|US20100036406 *||12 Oct 2009||11 Feb 2010||Alcon, Inc.||Method of Controlling a Surgical System Based on a Load on the Cutting Tip of a Handpiece|
|US20100057092 *||4 Mar 2010||Peterson Robert H||Varying Material Properties of a Single Fluidic Line in Ophthalmology Tubing|
|US20100087846 *||6 Oct 2008||8 Apr 2010||Dimalanta Ramon C||Phacoemulsification Tip with Internal Oriented Structures|
|US20100094201 *||13 Oct 2008||15 Apr 2010||Boston Scientific Scimed, Inc.||Assisted aspiration catheter system|
|US20100094321 *||10 Oct 2008||15 Apr 2010||Takayuki Akahoshi||Ultrasound Handpiece|
|US20100130914 *||6 Jan 2010||27 May 2010||Alcon, Inc.||Method Of Controlling A Surgical System Based On Irrigation Flow|
|US20100160897 *||8 Dec 2009||24 Jun 2010||Ducharme Richard W||Apparatus and Methods for Containing and Delivering Therapeutic Agents|
|US20100312102 *||20 Feb 2009||9 Dec 2010||Mayo Foundation For Medical Education And Research||Systems, devices, and methods for accessing body tissue|
|US20100324458 *||30 Jun 2010||23 Dec 2010||Olympus Corporation||Ultrasound treatment system|
|US20100324554 *||27 Aug 2010||23 Dec 2010||The Foundry, Llc||Aortic Valve Repair|
|US20100324581 *||3 Sep 2010||23 Dec 2010||Alcon, Inc.||Torsional Ultrasound Hand Piece That Eliminates Chatter|
|US20100331764 *||3 Sep 2010||30 Dec 2010||Alcon, Inc.||Controlling A Phacoemulsification Surgical System By Transitioning Between Pulse and Burst Modes|
|US20110004127 *||6 Jan 2011||Olympus Corporation||Ultrasound treatment system|
|US20110004149 *||1 Jul 2009||6 Jan 2011||Artsyukhovich Alexander N||Phacoemulsification hook tip|
|US20110015563 *||20 Jan 2011||Alcon, Inc.||Method Of Controlling A Surgical System Based On A Rate Of Change Of An Operating Parameter|
|US20110040212 *||16 Aug 2010||17 Feb 2011||Ethicon Endo-Surgery, Inc.||Ultrasonic Surgical Apparatus and Methods for Use Thereof|
|US20110040213 *||16 Aug 2010||17 Feb 2011||Ethicon Endo-Surgery, Inc.||Ultrasonic Surgical Apparatus with Silicon Waveguide|
|US20110112466 *||11 Nov 2009||12 May 2011||Ramon Carsola Dimalanta||Extended Point Phacoemulsification Tip|
|US20110118601 *||20 Feb 2009||19 May 2011||Mayo Foundation For Medical Education And Research Nonprofit Corporation||Ultrasound Guided Systems and Methods|
|US20110137231 *||8 Dec 2009||9 Jun 2011||Alcon Research, Ltd.||Phacoemulsification Hand Piece With Integrated Aspiration Pump|
|US20110137232 *||9 Dec 2009||9 Jun 2011||Alcon Research, Ltd.||Thermal Management Algorithm For Phacoemulsification System|
|US20110144567 *||15 Dec 2009||16 Jun 2011||Alcon Research, Ltd.||Phacoemulsification Hand Piece With Integrated Aspiration Pump and Cartridge|
|US20110160620 *||31 Dec 2009||30 Jun 2011||Tenex Health, Inc.||System and method for minimally invasive tissue treatment|
|US20110208114 *||28 Aug 2009||25 Aug 2011||Nigel Morlet||Cutting needle tip for surgical instrument|
|US20120083728 *||14 Dec 2011||5 Apr 2012||Gary Sorensen||Phacoemulsification hand piece with integrated aspiration pump|
|US20120083773 *||5 Apr 2012||Foster William J||Small diameter fragmatome for minimally traumatic retained lens fragments removal|
|US20120302938 *||29 Nov 2012||University Of Washington||Drainage systems for excess body fluids and associated methods|
|US20130197422 *||21 Mar 2011||1 Aug 2013||Uw Center For Commercialization||Failure resistant shunt|
|USRE30536 *||1 May 1978||3 Mar 1981||Cavitron Corporation||Ultrasonic device and method|
|USRE40388||8 May 2003||17 Jun 2008||Covidien Ag||Electrosurgical generator with adaptive power control|
|USRE43617||28 Aug 2012||Andrew Mark S||Tissue liquefaction and aspiration|
|CN102740905A *||3 Dec 2010||17 Oct 2012||爱尔康研究有限公司||Phacoemulsification hand piece with integrated aspiration pump|
|CN102740905B||3 Dec 2010||23 Jul 2014||爱尔康研究有限公司||Phacoemulsification hand piece with integrated aspiration pump|
|CN102844058A *||6 Dec 2010||26 Dec 2012||爱尔康研究有限公司||Phacoemulsification hand piece with integrated aspiration pump and cartridge|
|CN104055623A *||3 Dec 2010||24 Sep 2014||爱尔康研究有限公司||Phacoemulsification hand piece with integrated aspiration pump|
|DE2605968A1 *||14 Feb 1976||16 Sep 1976||Cavitron Corp||Vorrichtung fuer chirurgische zwecke|
|DE2741107A1 *||13 Sep 1977||29 Mar 1979||Heldt Gert Dipl Ing Dr||Verfahren zum loesen von ineinandergefuegten bauteilen|
|DE10056114A1 *||13 Nov 2000||29 May 2002||Wolfgang Malodobry||Narbenfreie Entfernung von Tätowierungen|
|DE19932032A1 *||9 Jul 1999||1 Feb 2001||Eppendorf Geraetebau Netheler||Vorrichtung zur Mikro-Dissektion von Gewebe|
|DE19932032C2 *||9 Jul 1999||24 Jul 2003||Eppendorf Ag||Vorrichtung zur Mikro-Dissektion von Gewebe|
|DE102009015911A1||3 Apr 2009||7 Oct 2010||Carl Zeiss Meditec Ag||Vorrichtung und Verfahren zur Entfernung eines Lentikels aus der Hornhaut|
|EP0139753A1 *||4 Apr 1983||8 May 1985||Sumitomo Bakelite Company Limited||Ultrasonic oscillator|
|EP0198703A2 *||14 Apr 1986||22 Oct 1986||The University of Aberdeen, University Court||Apparatus for removing biological material|
|EP0225690A1 *||15 Sep 1986||16 Jun 1987||Site Microsurgical Systems, Inc.||Aspiration fitting adaptor|
|EP0238667A1 *||15 Jul 1986||30 Sep 1987||Sumitomo Bakelite Company Limited||Ultrasonic instrument for surgical operations|
|EP0346496A1 *||23 Dec 1988||20 Dec 1989||Sumitomo Bakelite Company Limited||Excreting apparatus|
|EP0566565A1 *||14 Dec 1990||27 Oct 1993||Alcon Laboratories, Inc.||Tissue scraper element for medical use|
|EP0962203A1||3 May 1999||8 Dec 1999||Alcon Laboratories, Inc.||A liquefaction handpiece|
|EP0962204A1||3 May 1999||8 Dec 1999||Alcon Laboratories, Inc.||Control system for a liquefaction handpiece|
|EP0962205A1||3 May 1999||8 Dec 1999||Alcon Laboratories, Inc.||Tip for a liquefaction handpiece|
|EP1062958A1||13 Jun 2000||27 Dec 2000||Alcon Laboratories, Inc.||A control system for controlling the operating parameters of a surgical system|
|EP1080739A2||20 Jun 2000||7 Mar 2001||Alcon Universal, Ltd.||Liquid venting surgical system and cassette|
|EP1199054A1||28 Sep 2001||24 Apr 2002||Alcon Manufacturing Ltd.||Liquefracture handpiece tip|
|EP1285642A1||7 Aug 2001||26 Feb 2003||Alcon Manufacturing Ltd.||Apparatus and software for controlling an intraoperative temperature|
|EP1314409A2||28 Sep 2001||28 May 2003||Alcon Manufacturing Ltd.||Liquefracture handpiece|
|EP1356833A1||14 Mar 2003||29 Oct 2003||Alcon Inc.||Liquid venting surgical cassette|
|EP1356834A2||28 Mar 2003||29 Oct 2003||Alcon Inc.||Surgical aspiration system|
|EP1647248A1||5 Sep 2005||19 Apr 2006||Alcon, Inc||Low resistance irrigation system|
|EP1693027A1||10 Feb 2006||23 Aug 2006||Alcon, Inc||Phacoemulsification tip|
|EP1700584A1||20 Feb 2006||13 Sep 2006||Alcon, Inc.||Phacoemulsification tip|
|EP1716828A1||30 Mar 2006||2 Nov 2006||Alcon, Inc.||Low resistance irrigation system and apparatus|
|EP1832259A1||16 Aug 2006||12 Sep 2007||Alcon, Inc||Pulse amplitude manipulation for controlling a phacoemulsification surgical system|
|EP1917936A1 *||30 Aug 2007||7 May 2008||Alcon, Inc.||Ultrasound apparatus and method of use|
|EP1990032A1||9 May 2008||12 Nov 2008||Alcon, Inc.||Method of operating an ultrasound handpiece|
|EP2065001A1||21 Mar 2005||3 Jun 2009||Alcon, Inc.||System for controlling a surgical system based on a rate of change of an operating parameter|
|EP2243449A1||27 Jul 2005||27 Oct 2010||Alcon, Inc.||Ultrasonic handpiece|
|WO1981001363A1 *||21 Nov 1980||28 May 1981||Unisearch Ltd||Co-axial tube surgical infusion/suction cutter tip|
|WO1986002257A1 *||18 Oct 1985||24 Apr 1986||Coopervision, Inc.||Surgical cutting instrument for ultrasonic eye surgery|
|WO1986006964A1 *||22 Apr 1986||4 Dec 1986||Coopervision, Inc.||Cassette for surgical irrigation and aspiration|
|WO1987001926A1 *||27 Aug 1986||9 Apr 1987||Coopervision, Inc.||Rigid, transparent fluid conduit for surgical irrigation|
|WO1987006116A1 *||8 Apr 1987||22 Oct 1987||Cooper Lasersonics, Inc.||Irrigation/aspiration manifold and fittings for ultrasonic surgical aspiration system|
|WO1992010139A1 *||14 Dec 1990||25 Jun 1992||Kelman Charles D||Tissue scraper element for medical use|
|WO1992016246A1 *||31 Oct 1991||1 Oct 1992||Kelman Charles D||Apparatus, method for eye irrigation and aspiration|
|WO1992020310A1 *||7 May 1992||26 Nov 1992||Ophthalmocare, Inc.||Phaco handpiece providing fingertip control of ultrasonic energy|
|WO1994008518A1 *||8 Oct 1993||28 Apr 1994||Kelman Charles D||Cavitation-generating tip for disintegrating tissue|
|WO1996025883A1||20 Feb 1996||29 Aug 1996||Colman Ross Kraff||Expansile surgical sleeve apparatus and method for using same|
|WO1997049343A1 *||26 Jun 1997||31 Dec 1997||Gravlee Joseph F Jr||Phacoemulsification needle|
|WO1998007398A1||22 Aug 1997||26 Feb 1998||Oversby Pty. Ltd.||Intraocular irrigation/aspiration device|
|WO1998025557A1||29 Oct 1997||18 Jun 1998||Alcon Laboratories, Inc.||Liquefaction handpiece|
|WO1999018901A1||7 Apr 1998||22 Apr 1999||Alcon Laboratories, Inc.||Control system for a phacoemulsification handpiece|
|WO1999058179A1||25 Mar 1999||18 Nov 1999||Mackool Richard J||Angulated phacoemulsification needle whose outer surface converges and inner channel narrows|
|WO2000074615A2||1 Jun 2000||14 Dec 2000||Alcon Universal Ltd.||Phaco-emulsification needle|
|WO2001030282A1||12 Sep 2000||3 May 2001||Alcon Laboratories, Inc.||Liquefracture handpiece|
|WO2001030284A1||18 Sep 2000||3 May 2001||Alcon Laboratories, Inc.||Liquefracture handpiece|
|WO2001030285A1||18 Sep 2000||3 May 2001||Alcon Laboratories, Inc.||Liquefracture handpiece|
|WO2001037768A1||19 Sep 2000||31 May 2001||Alcon Laboratories, Inc.||Pumping chamber for a liquefracture handpiece|
|WO2001043675A1||19 Sep 2000||21 Jun 2001||Alcon Laboratories, Inc.||Method of controlling a liquefracture handpiece|
|WO2001052782A1||18 Dec 2000||26 Jul 2001||Alcon Laboratories, Inc.||Torsional ultrasonic handpiece|
|WO2002017833A1||7 Aug 2001||7 Mar 2002||Alcon Manufacturing, Ltd.||Method of controlling intraocular pressure and temperature|
|WO2004026150A2||19 Sep 2003||1 Apr 2004||Sherwood Sevices Ag||Electrosurgical instrument for fragmenting, cutting and coagulating tissue|
|WO2004066806A2 *||11 Sep 2003||12 Aug 2004||The Regents Of The University Of California||Aerosol device to deliver bioactive agent|
|WO2004066806A3 *||11 Sep 2003||11 Nov 2004||Michael E Gertner||Aerosol device to deliver bioactive agent|
|WO2010112184A1||27 Mar 2010||7 Oct 2010||Carl Zeiss Meditec Ag||Apparatus and method for removing a lenticule from the cornea|
|WO2011071775A1 *||3 Dec 2010||16 Jun 2011||Alcon Research, Ltd.||Phacoemulsification hand piece with integrated aspiration pump|
|WO2011075332A1 *||6 Dec 2010||23 Jun 2011||Alcon Research, Ltd.||Phacoemulsification hand piece with integrated aspiration pump and cartridge|
|U.S. Classification||604/22, 604/8, 604/27, 606/169, 606/128, 604/28|
|International Classification||A61B17/32, A61M1/00, A61F9/007|
|Cooperative Classification||A61B2017/320072, A61M1/0064, A61F9/00745, A61B2017/320084, A61B2017/320076, A61B17/320068|
|European Classification||A61B17/32U, A61M1/00K4, A61F9/007R2|
|21 Jul 1989||AS||Assignment|
Owner name: COOPER COMPANIES, INC., THE A CORP. OF DE
Free format text: RELEASED BY SECURED PARTY;ASSIGNOR:IRVING TRUST COMPANY;REEL/FRAME:005153/0640
Owner name: COOPER COMPANIES, INC., THE, CALIFORNIA
Free format text: SECURITY INTEREST;ASSIGNOR:AIG CAPITAL CORP.;REEL/FRAME:005184/0092
Effective date: 19890201
Owner name: UNION BANK
Free format text: SECURITY INTEREST;ASSIGNOR:COOPER COMPANIES, INC., THE, A CORP. OF DE;REEL/FRAME:005224/0559
Effective date: 19890202
Free format text: RELEASED BY SECURED PARTY;ASSIGNOR:IRVING TRUST COMPANY;REEL/FRAME:5153/640
Owner name: COOPER COMPANIES, INC., THE,CALIFORNIA
|30 Mar 1984||AS02||Assignment of assignor's interest|
Owner name: COOPERVISION, INC., 2801 ORCHARD PKWY., SAN JOSE,
Effective date: 19840313
Owner name: NORTIVAC INC
|30 Mar 1984||AS01||Change of name|
Owner name: CAITRON CORPORATION
Effective date: 19840227
Owner name: NORTIVAC INC
|30 Mar 1984||AS||Assignment|
Owner name: COOPERVISION, INC., 2801 ORCHARD PKWY., SAN JOSE,
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNOR:NORTIVAC INC;REEL/FRAME:004245/0389
Effective date: 19840313
Owner name: NORTIVAC INC
Free format text: CHANGE OF NAME;ASSIGNOR:CAITRON CORPORATION;REEL/FRAME:004245/0392
Effective date: 19840227