US3557787A - Disposable syringe - Google Patents

Disposable syringe Download PDF

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Publication number
US3557787A
US3557787A US732622A US3557787DA US3557787A US 3557787 A US3557787 A US 3557787A US 732622 A US732622 A US 732622A US 3557787D A US3557787D A US 3557787DA US 3557787 A US3557787 A US 3557787A
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Prior art keywords
tubular member
syringe
inner tubular
forward end
sealing
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US732622A
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Milton J Cohen
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31596—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing
    • A61M2005/31598—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms comprising means for injection of two or more media, e.g. by mixing having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/286—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
    • A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase

Definitions

  • gh in sealing relaer is formed with a g an injection needle in alignment in use with the inner tubular member.
  • PATENTEU JANZBIQYI SHEET 2 OF 2 DISPOSABLE SYRINGE This invention relates to a device for the administration of parenteral solutions and more particularly to a hypodermic syringe adapted to contain dry solids separate and apart from the dissolving or carrier liquids until, immediately prior to administration, the liquid is caused to flow into the compartment containing the solids for injection of the formed mixture.
  • the most effective means for maintaining the shelf life over extended periods of time is to maintain complete separation between the liquid carrier and the solids to be incorporated therein, until immediately prior to use. Maintenance of solid-liquid separation until time of use presents other problems with respect to ejecting and administering the solution containing the necessary concentration of ingredients and under the most sanitary conditions.
  • the usual practice is to introduce the solids into the liquid for solution in a suitable container from which the solution can be withdrawn into a syringe for injection. This procedure required the use of at least three separate containers and maintenance under sterile conditions as well as accurate measurement of the ingredients.
  • FIG. 1 is a sectional elevational view of the syringe embodying the features of this invention, with the elements illustrated prior to use;
  • FIG. 2 is a sectional elevational view of the syringe shown in FIG. 1 with the syringe partially actuated to effect displacement of the liquid carrier from the liquid chamber to the solids chamber for solution or admixture;
  • FIG. 3 is a sectional elevational view of the syringe shown in FIGS. 1 and 2 with the syringe in fully actuated position to effect displacement of the freshly prepared solution from the solids compartment for injection;
  • FIG. 4 is a sectional elevational view of a portion of the syringe shown in FIGS. 1 to 3 and showing a modification in the closure for the liquid containing compartment;
  • FIG. 5 is a sectional elevational view of the actuator which may also be used as a needle cover.
  • the syringe of this invention is formed with an outer casing l in the form of a tubular member, formed of glass, plastic or the like, having a continuous bore 2 extending therethrough from an open rearward end portion 3 to a neck portion 4 of smaller cross section, at the forward end.
  • the forward end is sealed by means of a disc member 5 held in place in sealing relationship across the open neck 6 of the tubular member I by means of a metal cap 7 which is crimped about the outer neck end portion of the tubular member while the inner portions 8 of the cap overlap the outer edge portions of the sealing disc member overlying the flattened end surface 9 of the tubular member.
  • a hub member II has a skirt portion I2 crimped about the skirt portion of the cap for securing the hub onto the neck end portion of the tubular member.
  • the hub is also formed with an intermediate collapsible or corrugated portion 13 extending forwardly in axial alignment with the forward end of the tubular member with a hub 14 on the forward end through which a hollow needle 15 extends with a sharpened end portion of the needle projecting into the interior of the hub member II for a distance less than the spaced relationship between the hub end and the diaphragm 5, when in normal position, thereby to locate the rearward end of the needle immediately in advance of the center of the diaphragm.
  • a second tubular member 20 of glass, plastic or the like material is dimensioned to have an outer wall to wall dimension which is less than the inner wall to wall dimension of the tubular member I to enable the former to be telescoped through the interior of the outer tubular member 1.
  • the second tubular member is similarly formed with a passage 21 extending from the open rearward end 22 through a neck portion 23 of smaller cross section at the forward end.
  • the forward neck end portion of the second tubular member is fitted with a rubber stopper 24 including an outer ribbed portion 25 fitted in gripping relationship about the neck and extending laterally beyond the walls of the second tubular member for a distance to effect sealing engagement with the inner walls of the outer tubular member 1 whereby the second tubular member is capable of the function of a piston movable axially relative the outer tubular member 1 thereby to provide a piston and cylinder arrangement between the two tubular members.
  • the rubber stopper 25 has a disc portion 26 which normally spans the forward end of the passage to seal the tubular member. It is further formed with one or more openings 27 in the lateral portions beyond the passage to enable flow of liquid from the second tubular member into the firstwhen the sealing disc 26 is flexed for displacement for sealing engagement with the end of the second tubular member. Again, the rearward end portion of the second tubular member is formed with an outwardly extending flanged portion 28 for use as a finger grip, as will hereinafter be described. The rearward end of the passage 21 is sealed with a rubber plug 30 mounted for axial displacement through the passage 21 as a piston within the cylinder defined by the second tubular member.
  • Means such as a threaded stud 31, is provided on the rearward end of the plug type piston for connection of an actuator 32 for displacement of the piston relative the cylinder.
  • the actuator 32 is in the form of a third elongate tubular member dimensioned to have a cross section less than the cross section of the passage 21 through the second tubular member and formed at one end with an internally threaded female portion 33 for threaded engagement onto the threaded plug 31.
  • the rearward end of the actuator is formed with an outwardly extending flanged portion 34, for use as a finger grip.
  • the actuator is capable of use as a needle cover to protect the needle when other than in position of use and which can be removed from the hub to expose the needle and for attachment to the plug for operation of the device, when in position of use.
  • the element supplies the dual function of a needle protector during nonuse and as an actuator in use.
  • fluid 35 is housed in sealing relationship within the second tubular member while the dry medicant is housed in sealing relationship within the first tubular member.
  • the loaded device can be shipped and stored for extended periods of time without deterioration of the ingredients and without exposure of the elements to nonsanitary conditions.
  • Administration is made without change of devices and without exposure of the freshly prepared solution or suspension by inserting the needle into the vessel or tissue.
  • the outer casing is grasped with the one hand with the needle fingers beneath the flanged portion 10.
  • the needle is inserted and the hub is compressed to effect relative movement between the needle and the rubber sealing diaphragm 5 whereby the rearward end of the needle punctures the diaphragm to bring the end of the needle into the chamber 2 for direct communication with the freshly prepared liquid system.
  • the thumb is pressed down onto the actuator which, at the end of its travel in the second tubular member, causes displacement of the second tubular member for movement as a piston through the cylindrical passage 2 of the first tubular member thereby forcibly to displace the freshly prepared liquid system from the interior of the first tubular member through the needle and into the tissue.
  • the entire device can be discarded.
  • the sealing disc 26 extends continuously in sealing engagement across the neck of the second tubular member but is provided with a slit 40 which maintains a sealing relationship until opened in response to the application of fluid pressure as the plug 30 is displaced forwardly through the passage 21.
  • a syringe assembly for injection comprising inner and outer tubular members with the inner members having an outer wall to wall dimension less than the inner wall to wall dimension of the outer tubular member to enable the inner tubular member to be telescoped within the outer tubular member, said inner tubular member defining a planar flange surface on the forward end thereof, a rupturable closure sealing the forward end of the outer tubular member, a.flexible closure having a resilient, thin web means across said flange surface and sealing the forward end of the inner tubular member, said thin web means including passage means therethrough seated on said flange surface in sealing relation thereto whereby said passage means are unseated to communicate with the interior of the inner tubular member in response to internal pressure therein, a piston ring portion on the forward end of the inner tubular member in sliding engagement with the inner walls of the outer tubular member.
  • a piston plug dimensioned slidably to be received within the inner tubular member, and means for actuating the piston plug axially relative to the inner tubular member, a hypodermic needle, and collapsible means on the forward end ortion of the outer tubular member supporting the needle wit the rear ward end terminating a short distance in advance of the rupturable closure when in uncollapsed position and penetrating through the rupturable closure when in collapsed position.
  • a syringe as claimed in claim 1 which includes a removable cover for the needle.
  • a syringe as claimed in claim 1 in which the inner tubular member is adapted to contain a liquid carrier and in which the outer tubular member is adapted to contain a dry material to be taken up by the liquid carrier when the latter is forced from the inner tubular member into the outer tubular member in response to movement of the piston plug axially in the inner tubular member.
  • a syringe as claimed in claim 1 in which the collapsible means comprises a hub member secured at its rearward end portion onto the forward end of the outer tubular member and a forward end having an opening through which the needle extends with a flexible portion between the ends to enable displacement of the forward end between normal and collapsed position.
  • a syringe as claimed in claim 1 in which the piston ring portion on the forward end of the inner tubular member comprises ring members of rubberlike material in sealing engagement with the outer walls of the inner tubular member and extending into sealing engagement with the inner walls of the outer tubular member.
  • a syringe as claimed in claim 1 in which the piston ring portion and flexible closure are of a unitary construction mounted onto the forward end portion of the inner tubular member and in which the means in the flexible sealing closure comprises openings extending through the sealing member in a position offset outwardly from axial alignment with the passage through the inner tubular member.
  • a syringe as claimed in claim 1 which includes means on the rearward end of the piston plug for attachment of an actuator and which includes an elongate actuator dimensioned to exceed the length of travel of the piston plug through the inner tubular member.
  • a syringe as claimed in claim 8 in which the actuator comprises an elongate rod dimensioned to be received in telescoping relation within the inner tubular member and with means for attachment of the actuator to the piston plug.
  • a syringe as claimed in claim 1 which includes flanged members extending radially outwardly from the rearward end portions of the inner and outer tubular members for use as finger grips.

Abstract

A syringe device formed of inner and outer tubular members with the inner member adapted to be telescoped within the outer member and sealed therefrom by a resilient, thin seal. The inner member has a planar flange surface on its forward end and across which the thin seal extends. The thin seal has passage means therethrough in sealing relation to the flange surface. The outer member is formed with a rupturable seal having an injection needle in alignment therewith for rupture in use with the inner tubular member. The inner member is adapted to contain a liquid carrier and the outer tubular member a dry medicant to be taken up with the carrier for injection whereby the materials are freshly mixed immediately prior to injection for operation of the device.

Description

United States Patent 721 inventor Milton .1. Cohen 330 .846 2/1967 Ogle...r..... 128/218(M) 5437 Connecticut Ave" Washington, 3,342,180 9/1967 Sandhage et 128/218(M) 20015 3,413,974 12/1968 Cohen l28/218(NV) d m .W mm wa na e m m Hh d m u e mmH a S 1% n m .mm .m mM E z o aw m inm rst PAA I 9% l 2 6 Q n w 7M]. 0. d n m d Wh m AHP un 7-7-4 {54] DISPOSABLE SYRINGE d outer tupted to be 10 Claims, 5 Drawing Figs.
a d a r e b m e m r e n .m e h t h .U w s r e b m e m m U ..D
resilient thin seal extends.
gh in sealing relaer is formed with a g an injection needle in alignment in use with the inner tubular member.
u hob mm 6 ct m er mm u m C a 30 d an nsanil em v P m a u a 1 W om fe m m mm w ommm en mnww f tr [50] Field of Search...v.............
[5 6] References Cited UNITED STATES PATENTS quid carrier and be taken up with y the materials are freshly njection for operation of the m .mm mm 0 0 e m t W 0 n @r e 10 3 mm m m m b mu an m u 1 me b e r.- 8 Wm n m .m n mp y m i r.m m -I em .11 mm ek t. ..md MmMM )8 88 1 11 2122 (l 008 0000 .12 22 21 I11 8 2 "u" w mm fwd. n m m m a h mm. fl CCb .lt..l OffifiO LKRRK 24593 55556 99999 HHHHH 44 0 647 3 0064 9 59900 97960 .6 2 22223 PATENIED JAN26 l97l 557- 787 SHEET 1 UF 2 Mw yz i A Lag) 0 I2,
PATENTEU JANZBIQYI SHEET 2 OF 2 DISPOSABLE SYRINGE This invention relates to a device for the administration of parenteral solutions and more particularly to a hypodermic syringe adapted to contain dry solids separate and apart from the dissolving or carrier liquids until, immediately prior to administration, the liquid is caused to flow into the compartment containing the solids for injection of the formed mixture.
To the present, it has been the practice to make use of stock solutions housed within a container of relatively large capacity, from which increments can be removed, as desired, for administration by a suitable syringe. This procedure is deemed to be unsatisfactory because most such solutions are of insufficient stability to militate against change before the stock solution has been used up. With a solution of short shelf life, its utility may become dissipated before the solution has been completely utilized.
The most effective means for maintaining the shelf life over extended periods of time is to maintain complete separation between the liquid carrier and the solids to be incorporated therein, until immediately prior to use. Maintenance of solid-liquid separation until time of use presents other problems with respect to ejecting and administering the solution containing the necessary concentration of ingredients and under the most sanitary conditions. The usual practice is to introduce the solids into the liquid for solution in a suitable container from which the solution can be withdrawn into a syringe for injection. This procedure required the use of at least three separate containers and maintenance under sterile conditions as well as accurate measurement of the ingredients.
It is an object of this invention to provide a single device in which accurately measured amounts of solid medicants and liquid carrier can be maintained in a completely separated relation, in which the measured amounts of liquid carrier and solid material can be brought together and in which the freshly formed mixture can be injected, all while maintaining the ingredients in a sealed and sanitary state, without exposure to the outside atmosphere, and in which the entire operation for mixture and administration can be carried out with one hand.
It is another object to provide a disposable syringe which houses the liquid and solids in separately sealed compartments and in which admixture of the liquid and solid can be efiected entirely within the confines of the syringe to make a freshly prepared solution of the measured ingredients and from which the freshly prepared solution can be injected in the manner desired for use. I
Other objects and advantages of this invention will hereinafter appear and, for purposes of illustration but not of limitation, an embodiment of the invention is shown in the accompanying drawings in which:
FIG. 1 is a sectional elevational view of the syringe embodying the features of this invention, with the elements illustrated prior to use;
FIG. 2 is a sectional elevational view of the syringe shown in FIG. 1 with the syringe partially actuated to effect displacement of the liquid carrier from the liquid chamber to the solids chamber for solution or admixture;
FIG. 3 is a sectional elevational view of the syringe shown in FIGS. 1 and 2 with the syringe in fully actuated position to effect displacement of the freshly prepared solution from the solids compartment for injection;
FIG. 4 is a sectional elevational view of a portion of the syringe shown in FIGS. 1 to 3 and showing a modification in the closure for the liquid containing compartment; and
FIG. 5 is a sectional elevational view of the actuator which may also be used as a needle cover.
With reference now to the drawings, the syringe of this invention is formed with an outer casing l in the form of a tubular member, formed of glass, plastic or the like, having a continuous bore 2 extending therethrough from an open rearward end portion 3 to a neck portion 4 of smaller cross section, at the forward end. The forward end is sealed by means of a disc member 5 held in place in sealing relationship across the open neck 6 of the tubular member I by means of a metal cap 7 which is crimped about the outer neck end portion of the tubular member while the inner portions 8 of the cap overlap the outer edge portions of the sealing disc member overlying the flattened end surface 9 of the tubular member. The rearward end of the tubular member is formed with an outwardly extending annular flange 10 which serves as a finger grip. A hub member II has a skirt portion I2 crimped about the skirt portion of the cap for securing the hub onto the neck end portion of the tubular member. The hub is also formed with an intermediate collapsible or corrugated portion 13 extending forwardly in axial alignment with the forward end of the tubular member with a hub 14 on the forward end through which a hollow needle 15 extends with a sharpened end portion of the needle projecting into the interior of the hub member II for a distance less than the spaced relationship between the hub end and the diaphragm 5, when in normal position, thereby to locate the rearward end of the needle immediately in advance of the center of the diaphragm.
A second tubular member 20 of glass, plastic or the like material is dimensioned to have an outer wall to wall dimension which is less than the inner wall to wall dimension of the tubular member I to enable the former to be telescoped through the interior of the outer tubular member 1. The second tubular member is similarly formed with a passage 21 extending from the open rearward end 22 through a neck portion 23 of smaller cross section at the forward end. The forward neck end portion of the second tubular member is fitted with a rubber stopper 24 including an outer ribbed portion 25 fitted in gripping relationship about the neck and extending laterally beyond the walls of the second tubular member for a distance to effect sealing engagement with the inner walls of the outer tubular member 1 whereby the second tubular member is capable of the function of a piston movable axially relative the outer tubular member 1 thereby to provide a piston and cylinder arrangement between the two tubular members.
The rubber stopper 25 has a disc portion 26 which normally spans the forward end of the passage to seal the tubular member. It is further formed with one or more openings 27 in the lateral portions beyond the passage to enable flow of liquid from the second tubular member into the firstwhen the sealing disc 26 is flexed for displacement for sealing engagement with the end of the second tubular member. Again, the rearward end portion of the second tubular member is formed with an outwardly extending flanged portion 28 for use as a finger grip, as will hereinafter be described. The rearward end of the passage 21 is sealed with a rubber plug 30 mounted for axial displacement through the passage 21 as a piston within the cylinder defined by the second tubular member. Means, such as a threaded stud 31, is provided on the rearward end of the plug type piston for connection of an actuator 32 for displacement of the piston relative the cylinder. In the illustrated modification, the actuator 32 is in the form of a third elongate tubular member dimensioned to have a cross section less than the cross section of the passage 21 through the second tubular member and formed at one end with an internally threaded female portion 33 for threaded engagement onto the threaded plug 31. The rearward end of the actuator is formed with an outwardly extending flanged portion 34, for use as a finger grip.
In the modification shown in FIG. 5, the actuator is capable of use as a needle cover to protect the needle when other than in position of use and which can be removed from the hub to expose the needle and for attachment to the plug for operation of the device, when in position of use. Thus the element supplies the dual function of a needle protector during nonuse and as an actuator in use. y
In the assembled relation, illustrated in FIG. I, fluid 35 is housed in sealing relationship within the second tubular member while the dry medicant is housed in sealing relationship within the first tubular member. The loaded device can be shipped and stored for extended periods of time without deterioration of the ingredients and without exposure of the elements to nonsanitary conditions.
transfers to the resilient closure disc 26 to cause flexure and unset the disc for establishing communication between the chambers 21 and 2 through the openings 27 to enable flow of fluid under pressure from the chamber 21 in the second tubular member into the chamber 2 of the first tubular member for admixture with the dry medicant 36. This intermediate position is illustrated in FIG. 2. The liquid carries the medicant into solution or suspension, with shaking when necessary, to provide a freshly prepared fluid system ready for administration by injection.
Administration is made without change of devices and without exposure of the freshly prepared solution or suspension by inserting the needle into the vessel or tissue. For this purpose, the outer casing is grasped with the one hand with the needle fingers beneath the flanged portion 10. The needle is inserted and the hub is compressed to effect relative movement between the needle and the rubber sealing diaphragm 5 whereby the rearward end of the needle punctures the diaphragm to bring the end of the needle into the chamber 2 for direct communication with the freshly prepared liquid system. Thereafter, the thumb is pressed down onto the actuator which, at the end of its travel in the second tubular member, causes displacement of the second tubular member for movement as a piston through the cylindrical passage 2 of the first tubular member thereby forcibly to displace the freshly prepared liquid system from the interior of the first tubular member through the needle and into the tissue.
Upon administration of the freshly prepared solution, the entire device can be discarded.
1n the modification shown in FIG. 4, the sealing disc 26 extends continuously in sealing engagement across the neck of the second tubular member but is provided with a slit 40 which maintains a sealing relationship until opened in response to the application of fluid pressure as the plug 30 is displaced forwardly through the passage 21.
It will be apparent from the foregoing that l have provided a simple disposable syringe capable of operation with one hand in which liquids and solids are maintained in separately sealed chambers and mixed immediatelyprior to injection by a simple operation of the device.
It will be understood that changes may be made in the details of construction, arrangement and operation without departing from the spirit of the invention, especially as defined in the following claims.
I claim:
1. A syringe assembly for injection comprising inner and outer tubular members with the inner members having an outer wall to wall dimension less than the inner wall to wall dimension of the outer tubular member to enable the inner tubular member to be telescoped within the outer tubular member, said inner tubular member defining a planar flange surface on the forward end thereof, a rupturable closure sealing the forward end of the outer tubular member, a.flexible closure having a resilient, thin web means across said flange surface and sealing the forward end of the inner tubular member, said thin web means including passage means therethrough seated on said flange surface in sealing relation thereto whereby said passage means are unseated to communicate with the interior of the inner tubular member in response to internal pressure therein, a piston ring portion on the forward end of the inner tubular member in sliding engagement with the inner walls of the outer tubular member. a piston plug dimensioned slidably to be received within the inner tubular member, and means for actuating the piston plug axially relative to the inner tubular member, a hypodermic needle, and collapsible means on the forward end ortion of the outer tubular member supporting the needle wit the rear ward end terminating a short distance in advance of the rupturable closure when in uncollapsed position and penetrating through the rupturable closure when in collapsed position.
2. A syringe as claimed in claim 1 which includes a removable cover for the needle.
3. A syringe as claimed in claim 1 in which the inner tubular member is adapted to contain a liquid carrier and in which the outer tubular member is adapted to contain a dry material to be taken up by the liquid carrier when the latter is forced from the inner tubular member into the outer tubular member in response to movement of the piston plug axially in the inner tubular member.
4. A syringe as claimed in claim 1 in which the collapsible means comprises a hub member secured at its rearward end portion onto the forward end of the outer tubular member and a forward end having an opening through which the needle extends with a flexible portion between the ends to enable displacement of the forward end between normal and collapsed position. v
5. A syringe as claimed in claim 1 in which the piston ring portion on the forward end of the inner tubular member comprises ring members of rubberlike material in sealing engagement with the outer walls of the inner tubular member and extending into sealing engagement with the inner walls of the outer tubular member.
6. A syringe as claimed in claim 1 in which the piston ring portion and flexible closure are of a unitary construction mounted onto the forward end portion of the inner tubular member and in which the means in the flexible sealing closure comprises openings extending through the sealing member in a position offset outwardly from axial alignment with the passage through the inner tubular member.
7. A syringe as claimed in claim 1 in which the piston plug within the inner tubular member is formed of rubberlike material having circular ribs dimensioned to extend into sealing engagement with the inner walls of the inner tubular member.
8. A syringe as claimed in claim 1 which includes means on the rearward end of the piston plug for attachment of an actuator and which includes an elongate actuator dimensioned to exceed the length of travel of the piston plug through the inner tubular member.
9. A syringe as claimed in claim 8 in which the actuator comprises an elongate rod dimensioned to be received in telescoping relation within the inner tubular member and with means for attachment of the actuator to the piston plug.
10. A syringe as claimed in claim 1 which includes flanged members extending radially outwardly from the rearward end portions of the inner and outer tubular members for use as finger grips.

Claims (10)

1. A syringe assembly for injection comprising inner and outer tubular members with the inner members having an outer wall to wall dimension less than the inner wall to wall dimension of the outer tubular member to enable the inner tubular member to be telescoped within the outer tubular member, said inner tubular member defining a planar flange surface on the forward end thereof, a rupturable closure sealing the forward end of the outer tubular member, a flexible closure having a resilient, thin web means across said flange surface and sealing the forward end of the inner tubular member, said thin web means including passage means therethrough seated on said flange surface in sealing relation thereto whereby said passage means are unseated to communicate with the interior of the inner tubular member in response to internal pressure therein, a piston ring portion on the forward end of the inner tubular member in sliding engagement with the inner walls of the outer tubular member, a piston plug dimensioned slidably to be received within the inner tubular member, and means for actuating the piston plug axially relative to the inner tubular member, a hypodermic needle, and collapsible means on the forward end portion of the outer tubular member supporting the needle with the rearward end terminating a short distance in advance of the rupturable closure when in uncollapsed position and penetrating through the rupturable closure when in collapsed position.
2. A syringe as claimed in claim 1 which includes a removable cover for the needle.
3. A syringe as claimed in claim 1 in which the inner tubular member is adapted to contain a liquid carrier and in which the outer tubular member is adapted to contain a dry material to be taken up by the liquid carrier when the latter is forced from the inner tubular member into the outer tubular member in response to movement of the piston plug axially in the inner tubular member.
4. A syringe as claimed in claim 1 in which the collapsible means comprises a hub member secured at its rearward end portion onto the forward end of the outer tubular member and a forward end having an opening through which the needle extends with a flexible portion between the ends to enable displacement of the forward end between normal and collapsed position.
5. A syringe as claimed in claim 1 in which the piston ring portion on the forward end of the inner tubular member comprises ring members of rubberlike material in sealing engagement with the outer walls of the inner tubular member and extending into sealing engagement with the inner walls of the outer tubular member.
6. A syringe as claimed in claim 1 in which the piston ring portion and flexible closure are of a unitary construction mounted onto the forward end portion of the inner tubular member and in which the means in the flexible sealing closure comprises openings extending through the sealing member in a position offset outwardly from axial alignment with the passage through the inner tubular member.
7. A syringe as claimed in claim 1 in which the piston plug within the inner tubular member is formed of rubberlike material having circular ribs dimensioned to extend into sealing engagement with the inner walls of the inner tubular member.
8. A syringe as claimed in claim 1 which includes means on the rearward end of the piston plug for attachment of an actuator and which includes an elongate actuator dimensioned to exceed the length of travel of the piston plug through the inner tubular member.
9. A syringe as claimed in claim 8 in which the actuator comprises an elongate rod dimensioned to be received in telescoping relation within the inner tubular member and with means for attachment of the actuator to the piston plug.
10. A syringe as claimed in claim 1 which includes flanged members extending radially outwardly from the rearward end portions of the inner and outer tubular members for use as finger grips.
US732622A 1968-05-28 1968-05-28 Disposable syringe Expired - Lifetime US3557787A (en)

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US73262268A 1968-05-28 1968-05-28

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JP (1) JPS51398B1 (en)
BE (1) BE733744A (en)
CH (1) CH489248A (en)
DE (1) DE1965990A1 (en)
FR (1) FR2011003B1 (en)
GB (1) GB1263949A (en)
IL (1) IL32209A (en)
SE (1) SE364185B (en)

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US3678931A (en) * 1970-06-09 1972-07-25 Milton J Cohen Syringe
US3687296A (en) * 1971-03-26 1972-08-29 Ewi Research & Dev Corp Fluid separator
US3718139A (en) * 1970-08-21 1973-02-27 G Hanford Syringe
US3757779A (en) * 1971-05-24 1973-09-11 Century Labor Inc Filter syringe
US3807119A (en) * 1972-06-21 1974-04-30 W Shields Method of assembling a multiple compartment hypodermic syringe
US4116240A (en) * 1977-03-11 1978-09-26 Guiney Aeneas C Mixing syringe
US4303069A (en) * 1978-10-30 1981-12-01 Cohen Milton J Hypodermic syringe with needle guide
US4405317A (en) * 1981-09-30 1983-09-20 The West Company Syringe assembly
US4781701A (en) * 1986-07-11 1988-11-01 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Syringe for medical purposes
US5156598A (en) * 1988-12-06 1992-10-20 C. R. Bard, Inc. Prefilled syringe delivery system
US5429603A (en) * 1990-12-04 1995-07-04 Medinject A/S Two-compartment syringe assembly and a method of producing a two-compartment syringe assembly
US5662472A (en) * 1995-08-18 1997-09-02 Dentsply Gmbh Hue and lightness identification system for dental products
EP1039946A2 (en) * 1997-12-19 2000-10-04 United States Surgical Corporation Fibrin mixture and dispenser assembly
US20030026849A1 (en) * 1997-10-15 2003-02-06 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
US6726005B2 (en) 2001-09-13 2004-04-27 Kerr Corporation Dental capsule
US20050090781A1 (en) * 2001-12-13 2005-04-28 Tokumi Baba Administration instrument for medical use
US6942639B2 (en) 1996-04-30 2005-09-13 Medtronic, Inc. Autologous platelet gel delivery system
WO2006128915A1 (en) * 2005-06-02 2006-12-07 Schwoebel Eckhard Multi-cylinder syringe
US20080000835A1 (en) * 2005-05-17 2008-01-03 Fresenius Medical Care North America Hemodialysis methods and apparatus
US20080058732A1 (en) * 2006-08-30 2008-03-06 Arthur Harris Continuous Feed Hypodermic Syringe with Self Contained Cartridge Dispenser
US20090026123A1 (en) * 1996-04-30 2009-01-29 Dolecek Victor D System for the production of autologus platelet gel useful for the delivery of medicinal and genetic agents
EP2173401A1 (en) * 2007-07-27 2010-04-14 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (pd) solutions
US20100310426A1 (en) * 2007-09-06 2010-12-09 Siemens Healthcare Diagnostics Inc. Reagent cartridge
EP2311513A1 (en) * 2009-10-16 2011-04-20 Sanofi-Aventis Deutschland GmbH Cartridge holder assembly for a drug delivery device
CN102641145A (en) * 2011-02-21 2012-08-22 三井化学株式会社 Device and kit for mixing three components
US20120258422A1 (en) * 2011-04-11 2012-10-11 Voco Gmbh Mixing and application capsule for producing a dental preparation
US8328784B2 (en) 2005-01-28 2012-12-11 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions
CN104023770A (en) * 2011-12-22 2014-09-03 B.布劳恩梅尔松根公司 Multi-chamber mixing container
US20150065991A1 (en) * 2012-04-09 2015-03-05 Becton, Dickinson And Company Vial dosing systems and methods
CN105366172A (en) * 2015-09-25 2016-03-02 （株）沃卓皮肤科技 Facial mask set
CN105377327A (en) * 2013-03-22 2016-03-02 安姆根有限公司 Injector and method of assembly
US20160296704A1 (en) * 2013-10-24 2016-10-13 Amgen Inc. Injector and method of assembly
US9585810B2 (en) 2010-10-14 2017-03-07 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser
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US3678931A (en) * 1970-06-09 1972-07-25 Milton J Cohen Syringe
US3718139A (en) * 1970-08-21 1973-02-27 G Hanford Syringe
US3687296A (en) * 1971-03-26 1972-08-29 Ewi Research & Dev Corp Fluid separator
US3757779A (en) * 1971-05-24 1973-09-11 Century Labor Inc Filter syringe
US3807119A (en) * 1972-06-21 1974-04-30 W Shields Method of assembling a multiple compartment hypodermic syringe
US4116240A (en) * 1977-03-11 1978-09-26 Guiney Aeneas C Mixing syringe
US4303069A (en) * 1978-10-30 1981-12-01 Cohen Milton J Hypodermic syringe with needle guide
US4405317A (en) * 1981-09-30 1983-09-20 The West Company Syringe assembly
US4781701A (en) * 1986-07-11 1988-11-01 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Syringe for medical purposes
US5156598A (en) * 1988-12-06 1992-10-20 C. R. Bard, Inc. Prefilled syringe delivery system
US5429603A (en) * 1990-12-04 1995-07-04 Medinject A/S Two-compartment syringe assembly and a method of producing a two-compartment syringe assembly
US5662472A (en) * 1995-08-18 1997-09-02 Dentsply Gmbh Hue and lightness identification system for dental products
US20050236325A1 (en) * 1996-04-30 2005-10-27 Medtronic, Inc. Method for the production of a blood component composition
US7413652B2 (en) 1996-04-30 2008-08-19 Arteriocyte Medical Systems, Inc. Method for the production of a blood component composition
US7934603B2 (en) 1996-04-30 2011-05-03 Arteriocyte Medical Systems, Inc. Autologous platelet gel spray delivery system
US20090026123A1 (en) * 1996-04-30 2009-01-29 Dolecek Victor D System for the production of autologus platelet gel useful for the delivery of medicinal and genetic agents
US6942639B2 (en) 1996-04-30 2005-09-13 Medtronic, Inc. Autologous platelet gel delivery system
US20050209081A1 (en) * 1996-04-30 2005-09-22 Medtronic, Inc. Autologous platelet gel spray delivery system
US20030026849A1 (en) * 1997-10-15 2003-02-06 Thomas Jefferson University Nitric oxide donor compositions, methods, apparatus, and kits for preventing or alleviating vasoconstriction or vasospasm in a mammal
US6796966B2 (en) * 1997-10-15 2004-09-28 Jeffrey E. Thomas Apparatus, and kits for preventing of alleviating vasoconstriction or vasospasm in a mammal
EP1955727A3 (en) * 1997-12-19 2008-11-05 United States Surgical Corporation Fibrin mixture and dispenser assembly
EP1039946A4 (en) * 1997-12-19 2004-07-21 United States Surgical Corp Fibrin mixture and dispenser assembly
EP1039946A2 (en) * 1997-12-19 2000-10-04 United States Surgical Corporation Fibrin mixture and dispenser assembly
US6726005B2 (en) 2001-09-13 2004-04-27 Kerr Corporation Dental capsule
US20110028906A1 (en) * 2001-12-13 2011-02-03 Tokumi Baba Administration instrument for medical use
US20050090781A1 (en) * 2001-12-13 2005-04-28 Tokumi Baba Administration instrument for medical use
US8974413B2 (en) 2001-12-13 2015-03-10 Panasonic Healthcare Co., Ltd. Administration instrument for medical use
US20110033832A1 (en) * 2001-12-13 2011-02-10 Tokumi Baba Administration instrument for medical use
US7922699B2 (en) * 2001-12-13 2011-04-12 Panasonic Corporation Administration instrument for medical use
US10463800B2 (en) 2001-12-13 2019-11-05 Phc Holdings Corporation Administration instrument for medical use
US8287500B2 (en) 2001-12-13 2012-10-16 Panasonic Corporation Administration instrument for medical use
US9180069B2 (en) 2005-01-28 2015-11-10 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions
US8328784B2 (en) 2005-01-28 2012-12-11 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions
US20080000835A1 (en) * 2005-05-17 2008-01-03 Fresenius Medical Care North America Hemodialysis methods and apparatus
WO2006128915A1 (en) * 2005-06-02 2006-12-07 Schwoebel Eckhard Multi-cylinder syringe
US20080058732A1 (en) * 2006-08-30 2008-03-06 Arthur Harris Continuous Feed Hypodermic Syringe with Self Contained Cartridge Dispenser
US9233206B2 (en) * 2006-08-30 2016-01-12 Arthur Harris Continuous feed hypodermic syringe with self contained cartridge dispenser
EP2173401A1 (en) * 2007-07-27 2010-04-14 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (pd) solutions
EP2173401A4 (en) * 2007-07-27 2012-03-21 Fresenius Med Care Hldg Inc Systems and methods for delivery of peritoneal dialysis (pd) solutions
US8268263B2 (en) * 2007-09-06 2012-09-18 Siemens Healthcare Diagnostics Inc. Reagent cartridge
US20100310426A1 (en) * 2007-09-06 2010-12-09 Siemens Healthcare Diagnostics Inc. Reagent cartridge
US10369228B2 (en) 2009-03-26 2019-08-06 Jeffrey E. Thomas Method and composition for alleviating or preventing ischemic tissue damage
US9067018B2 (en) 2009-10-16 2015-06-30 Sanofi-Aventis Deutschland Gmbh Cartridge holder assembly for a drug delivery device
WO2011054648A3 (en) * 2009-10-16 2011-06-30 Sanofi-Aventis Deutschland Gmbh Cartridge holder assembly for a drug delivery device
EP2311513A1 (en) * 2009-10-16 2011-04-20 Sanofi-Aventis Deutschland GmbH Cartridge holder assembly for a drug delivery device
US9585810B2 (en) 2010-10-14 2017-03-07 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser
US10842714B2 (en) 2010-10-14 2020-11-24 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter chamber diffuser
US11779519B2 (en) 2010-10-14 2023-10-10 Fresenius Medical Care Holdings, Inc. Systems and methods for delivery of peritoneal dialysis (PD) solutions with integrated inter-chamber diffuser
CN102641145A (en) * 2011-02-21 2012-08-22 三井化学株式会社 Device and kit for mixing three components
US20120258422A1 (en) * 2011-04-11 2012-10-11 Voco Gmbh Mixing and application capsule for producing a dental preparation
US9549787B2 (en) * 2011-04-11 2017-01-24 Voco Gmbh Mixing and application capsule for producing a dental preparation
EP2510897A3 (en) * 2011-04-11 2015-02-18 VOCO GmbH Mixing and application capsule for producing a dental preparation
US11160931B2 (en) 2011-10-14 2021-11-02 Amgen Inc. Method of assembling and filling a drug delivery device
US11298463B2 (en) 2011-10-14 2022-04-12 Amgen Inc. Method of assembling and filling a drug delivery device
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US9987428B2 (en) 2011-10-14 2018-06-05 Amgen Inc. Injector and method of assembly
US11110225B2 (en) 2011-10-14 2021-09-07 Amgen Inc. Injector and method of assembly
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US10314976B2 (en) 2011-10-14 2019-06-11 Amgen Inc. Method of assembling and filling a drug delivery device
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US11058821B2 (en) * 2011-10-14 2021-07-13 Amgen Inc. Injector and method of assembly
CN104023770A (en) * 2011-12-22 2014-09-03 B.布劳恩梅尔松根公司 Multi-chamber mixing container
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US10569018B2 (en) * 2012-04-09 2020-02-25 Becton, Dickinson And Company Vial dosing systems and methods
US20150065991A1 (en) * 2012-04-09 2015-03-05 Becton, Dickinson And Company Vial dosing systems and methods
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US11759571B2 (en) 2013-03-22 2023-09-19 Amgen Inc. Injector and method of assembly
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US20160296704A1 (en) * 2013-10-24 2016-10-13 Amgen Inc. Injector and method of assembly
US11097055B2 (en) * 2013-10-24 2021-08-24 Amgen Inc. Injector and method of assembly
USD831203S1 (en) 2015-03-02 2018-10-16 Neomed, Inc. Enteral syringe
USD807502S1 (en) 2015-03-02 2018-01-09 Neomed, Inc. Enteral syringe
USD831204S1 (en) 2015-03-02 2018-10-16 Neomed, Inc. Enteral syringe
US10307337B2 (en) 2015-03-24 2019-06-04 Neomed, Inc. Oral administration coupler for back-of-mouth delivery
US10624817B2 (en) 2015-03-24 2020-04-21 Neomed, Inc. Oral administration coupler for back-of-mouth delivery
US10682287B2 (en) 2015-07-14 2020-06-16 Neomed, Inc. Dosing control coupling for enteral fluid transfer and enteral couplings and syringes
US10420709B2 (en) 2015-07-14 2019-09-24 Neomed, Inc. Dosing control coupling for enteral fluid transfer
CN105366172B (en) * 2015-09-25 2018-01-16 傲卓股份有限公司 Facial mask is set with
CN105366172A (en) * 2015-09-25 2016-03-02 （株）沃卓皮肤科技 Facial mask set
WO2017083622A1 (en) * 2015-11-13 2017-05-18 Bayer Healthcare Llc Nested syringe assembly
US11744948B2 (en) 2015-11-13 2023-09-05 Bayer Healthcare Llc Nested syringe assembly
US10835674B2 (en) 2015-11-13 2020-11-17 Bayer Healthcare Llc Nested syringe assembly
US10874799B2 (en) 2015-11-27 2020-12-29 Sanofi-Aventis Deutschland Gmbh Medicament delivery device
WO2017089272A1 (en) * 2015-11-27 2017-06-01 Sanofi-Aventis Deutschland Gmbh Medicament delivery device

Also Published As

Publication number Publication date
GB1263949A (en) 1972-02-16
JPS51398B1 (en) 1976-01-07
IL32209A (en) 1972-07-26
DE1965990A1 (en) 1971-02-11
IL32209A0 (en) 1969-07-30
SE364185B (en) 1974-02-18
FR2011003B1 (en) 1974-06-14
FR2011003A1 (en) 1970-02-27
DE1926387A1 (en) 1969-12-11
BE733744A (en) 1969-11-03
CH489248A (en) 1970-04-30

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