|Publication number||US3485235 A|
|Publication date||23 Dec 1969|
|Filing date||4 Dec 1967|
|Priority date||4 Dec 1967|
|Publication number||US 3485235 A, US 3485235A, US-A-3485235, US3485235 A, US3485235A|
|Original Assignee||Felson Ronald|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (3), Referenced by (56), Classifications (13)|
|External Links: USPTO, USPTO Assignment, Espacenet|
R. FELSON 3,485,235
CAPSULE FOR THE STUDY AND TREATMENT OF THE DIGESTIVE TRACT Dec. 23, 1969 Filed Dec.
INVENTOR, Ronald Felson ATTORNEY United States Patent US. Cl. 128-2 7 Claims ABSTRACT OF THE DISCLOSURE The longitudinal expansion and contraction of a swallowable telescopic plastic casing is accomplished by heating an ether-filled bellows contained in said casing. The casing parts have openings acting as a valve so the casing is closed when in contracted condition, and open when expanded. The capsule so constituted in contracted condition, is ingested empty or filled with a medicament. The passage of the capsule through the digestive tract is observed with an X-ray apparatus, and when it reaches a certain level, a heat is produced in the patients body by electrical means creating a high frequency magnetic field, which is controlled to operate the bellows to open and close the casing. If the capsule used was empty, it will receive a sample of the fluid of the digestive tract at the zone wherein the capsule was operated. If the capsule used was originally laden with a medicament, the latter will be discharged into said tract, at the selected zone. Later, the capsule is recovered from the feces with the aid of a magnet. The bellows structure includes as its extensible, contractible member, a circumferentially corrugated steel foil tube.
The present invention relates to a capsule to be used for the clinical, physiological and physiopathological examination, study and treatment of the digestive tract and more particularly to a type which is easily swallowed by the patient and then recovered in the feces. Its movement in the body can be observed by X-rays and it can be operated to extract a sample at any level in its travel, of the fluids in the zone of interest or it may carry some chemical or medicament to be discharged into such zone. Essentially, the construction of the capsule affords its opening and closing by controlled radiant heat induced in the body.
Various complicated and costly capsule constructions have heretofore been suggested. Laden with room filling mechanism, leaving hardly any available capacity for sample gathering or medicament carrying, and being slow in action, besides being expensive, hinders their adoption.
It is therefore the principal object of this invention to provide a novel and improved construction for a capsule of the character described, which is simple in structure, easy and reasonable in cost to manufacture, quick to assume open and closed condition and avoiding the objectionable features mentioned, makes for eflicient accomplishment of the purposes for which it is designed.
Other objects and advantages will become apparent as this disclosure proceeds.
For one practice of this invention, part of the interior of a swallowable casing made up of two telescopicallyassociated shells, is taken up by a normally contracted, ether-filled bellows-form chamber whose resilient, longitudinally extensible and contractible member is a circumferentially corrugated steel foil tube. One end of the bellows is fixed at the bottom of one of the shells, and its other end serves as a slidably fitted piston in such one shell, which is provided with an end wall so it is a cylinder structure for said piston. The piston rod extends slidably through such cylinder end, and its distal end extends and is secured to the bottom of the other shell 3,485,235 Patented Dec. 23, 1969 "ice which serves as a cap on the first one. Each shell at mouth end has openings. When the bellows is in contracted condition, which is the normal, said openings are non-communicative, and the cylinders interior is confined. But upon extension of the bellows, said openings come into registry. So these openings form a sort-of valve construction. Passage of the capsule, empty or containing a medicament, through the digestive tract, is observed by means of X-ray apparatus. The expansion and subsequent contraction of the bellows to open and close the casing, is accomplished by controlled electrically induced heat caused to occur in the patients body when the capsule has reached a predetermined zone in the digestive tract, whereupon the empty capsule will receive a sample, and the initially laden capsule will have its contents discharged. Later, the capsule is recovered in the feces with the aid of a magnet.
In the accompanying drawing forming part of this specification similar characters of reference indicate corresponding parts in all the views.
FIG. 1 is a magnified, central elevational section showing a capsule embodying the teachings of this invention, in closed condition, holding a supply of a medicament.
FIG. 2 is a view like FIG. 1, shown only partly in section, but empty.
FIG. 3 is a view like FIG. 2, showing the capsule in open condition.
FIG. 4 is a section taken at line 4-4 in FIG. 3.
In the drawing, the capsule indicated generally by the numeral 15, is made of the two telescopically associated shells 16 and 17, to form an expandible and contractible envelope of swallowable size. The shell 16 serves as a cap on the shell 17, while the latter is provided with an end wall 18 near its mouth, so it is a cylinder for the slidably fitted piston 19, whose rod 20, extends slidingly through the cylinder end 18, to the floor of the cap shell 16, where it is secured at 21. To the floor of the shell 17, is secured the lower end of a bellows-form chamber indicated generally by the numeral 22, comprised of a cylindrical Wall 23, closed at both ends, as shown at 24, and the piston 19 may serve as its top end; said cylindrical wall being a resilient, longitudinally expandable and contractible circumferentially corrugated tube. The bellows chamber is filled with a gas as ether for instance, which quickly expands, when heated. The corrugated tube 23 is preferably made of steel foil plated exteriorally with gold. The piston rod may be of fiberglass. The shells 16 and 17 may be of Teflon or other suitable material which is inert to the contents of the digestive tract and to chemicals and medicaments which in some instances are intended to be carried by the capsule in the space above the bellows chamber, and discharged therefrom into said tract; said shells near month end, having openings, which register respectively when the bellows chamber expands as shown in FIG. 3, but are noncommunicative when said bellows chamber is in its contracted condition, as shown in the FIGS. 1 and 2. Said openings in the cap 16, are indicated by the numeral 25, and in the other shell, by the numeral 26. Seals as 27, 27', 27" are provided to maintain the openings non-communicative with the interior of the shell 17, while the bellows 22 is in contracted condition. Said bellows in such condition which is the normal, occupy about one-third of the shell 17 in the embodiment illustrated, leaving the space which is shown vacant in FIG. 2, but in FIG. 1, it is shown containing a medicament 29. In expanded state, the bellows 22 reaches to about the openings 26. The numerals 21 and 28, denote suitable cement as Epoxy for example, to effect assembly.
The capsule 15, is prepared in contracted condition, loaded as in FIG. 1, when it is desired to discharge the medicament 29 into the digestive tract, or empty as in FIG. 2, when it is desired to have the capsule receive a sample of the fluid in said tract. In use, the capsule is swallowed by the patient and its passage is observed by means of X-rays. When it has reached the desired zone in the digestive tract to be investigated or treated, heat is induced in the body by electrical generation so the capsule is heated sufficient to work on the bellows to cause expansion of the ether and hence the bellows expand to the condition as shown in FIG. 3, whereupon the shells 16 and 17 will move in relation to each other to elongate the envelope they comprise, so the openings 25 and 26 will become communicative. Used in this art to induce the required heat for operation of the capsule, is apparatus creating a high frequency magnetic induction field which raises the temperature of the ferro-magnetic material, which here, is the corrugated tube 23. Said heating apparatus and its manipulations and use, is well known in this art, as well as the use of the X-ray apparatus, so further illustration of explanation thereof is believed unnecessary.
If the capsule used is as in FIG. 1, then the medicament will be discharged by action of the piston 19, into the digestive tract. If the capsule used is as in FIG. 2, a sample of the fluids in the selected zone of the tract, will be free to enter through said valve openings 25, 26, into the space 30. In either case, upon removal of the heat influence, the bellows will contract, whereupon piston movement will cause a sucking in of tract fiuid into the shell 17, which is aided by the slight vacuum caused by the pistons retraction. Later, the spent or laden capsule, as the case may be, is retrieved from the feces. Aid can be had for this, by use of a magnet to attract the capsule, since it bellowss tube 23 is of ferrous material.
The capsule 15, when to be ingested empty as in FIG. 2, for gaining a sample, may be prepared with its interior rarified by vacuum apparatus. This will insure in inrush of tract fluid when the capsule is extended, through the valve openings 25, 26.
Other suitable fillers for the bellows, are acetone, alcohol and methylenechloride.
This invention is capable of numerous forms and various applications without departing from the essential features herein disclosed. It is therefore intended and desired that the embodiments shown herein shall be deemed merely illustrative and not restrictive and that the patent shall cover all patentable novelty herein set forth; reference being had to the following claims rather than to the specific showing herein and the description given, to indicate the scope of this invention.
1. In a swallowable capsule of the character described. an envelope consisting of two shells associated in slidable telescopic relation hole structure in at least one of the shells, so positioned that the interior and exterior of the envelope are non-communicative, and as the shells move to expand the envelope, the opening provides fluid passage means between the interior and exterior of the envelope, a bellows normally in contracted condition, positioned within the envelope; said bellows comprising a longitudinally extensible and contractible tubular member closed by end elements, means securing the ends of said bellows to said shells respectively, so that upon expansion of the bellows, the envelope will expand and then upon contraction of said bellows, said envelope will contract; at least part of said bellows being of a ferrous material adapted to be heated by action of radiant energy generated externally of the capsule; said bellows being filled by a gas which readily expands, causing the bellows to expand, when said radiant energy is applied to influence said ferrous material.
2. A capsule as defined in claim 1, wherein said tubular member of the bellows is a circumferentially corrugated tube, which is longitudinally resilient.
3. A capsule as defined in claim 2, wherein said tube is of steel foil.
4. A capsule as defined in claim 1, wherein one of the shells is a cap on the second shell; said second shell having an end wall closing its month end so that said second shell constitutes a cylinder; the means securing the end element of the bellows to the cap, being a piston rod slidably mounted through said cylinder end wall, and said last mentioned end element of the bellows being a piston slidably fitted in said cylinder; said hole being in the cylinder, near its end wall through which the piston rod is positioned.
5. A capsule as defined in claim 4, wherein said tubular member of the bellows is a circumferentially corrugated tube which is longitudinally resilient.
6. A capsule as defined in claim 4, wherein said tube is of steel foil.
7. A capsule as defined in claim 1, wherein the gas has the expansion and contraction properties of ether when heated and then cooled.
References Cited UNITED STATES PATENTS 3,057,344 10/ 1962; Abella et a1. 128-2 3,118,439 1/1964 Perrenood l28-2 3,315,660 4/1967 Abella 1282 WILLIAM E. KAMM, Primary Examiner US. Cl. X.R. 128260
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US3057344 *||21 May 1957||9 Oct 1962||Alberto Abella Carlos||Capsule for the study of the digestive tract and method of using the same|
|US3118439 *||19 Mar 1958||21 Jan 1964||Jean-Pierre Perrenoud||Diagnostic and medicating capsule and the method of use|
|US3315660 *||8 Aug 1963||25 Apr 1967||Abella Carlos A||Capsule for insertion in the digestive track|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US3608549 *||15 Jan 1970||28 Sep 1971||Merrill Edward Wilson||Method of administering drugs and capsule therefor|
|US3659600 *||24 Feb 1970||2 May 1972||Charles River Foundation The||Magnetically operated capsule for administering drugs|
|US3692027 *||23 Apr 1971||19 Sep 1972||Ellinwood Everett H Jr||Implanted medication dispensing device and method|
|US3786813 *||27 Dec 1972||22 Jan 1974||Alza Corp||Drug delivery device with self actuated mechanism for retaining device in selected area|
|US3788322 *||27 Dec 1972||29 Jan 1974||Alza Corp||Drug delivery device with means for maintaining device in environment of use|
|US3840009 *||27 Dec 1971||8 Oct 1974||Alza Corp||Self-powered vapor pressure delivery device|
|US3894538 *||6 Aug 1973||15 Jul 1975||Siemens Ag||Device for supplying medicines|
|US4030499 *||7 Jun 1976||21 Jun 1977||Louis Bucalo||Method and apparatus for providing living beings with absorbable implants|
|US4036214 *||14 Apr 1975||19 Jul 1977||Louis Bucalo||Fluid-collecting and microorganism-detecting devices|
|US4172446 *||30 Dec 1975||30 Oct 1979||Louis Bucalo||Apparatus for collecting body fluids|
|US4186730 *||2 Dec 1976||5 Feb 1980||Louis Bucalo||Methods for collecting body fluids|
|US4192308 *||26 Dec 1978||11 Mar 1980||Alza Corporation||Device using prestretched polymer for dispensing medication|
|US4232673 *||11 Aug 1975||11 Nov 1980||Louis Bucalo||Method for collecting and processing body fluids|
|US4257427 *||13 Sep 1979||24 Mar 1981||Louis Bucalo||Method for collecting body fluids|
|US4325388 *||9 Feb 1979||20 Apr 1982||Louis Bucalo||Apparatus for collecting and processing body fluids|
|US4439197 *||15 Mar 1982||27 Mar 1984||Olympus Optical Co., Ltd.||Medical capsule device|
|US4481952 *||21 Mar 1979||13 Nov 1984||Jerzy Pawelec||Device for the study of the alimentary canal|
|US4507115 *||28 Feb 1984||26 Mar 1985||Olympus Optical Co., Ltd.||Medical capsule device|
|US4830855 *||13 Nov 1987||16 May 1989||Landec Labs, Inc.||Temperature-controlled active agent dispenser|
|US5167626 *||27 Jan 1992||1 Dec 1992||Glaxo Inc.||Medical capsule device actuated by radio-frequency (RF) signal|
|US5170801 *||2 Oct 1990||15 Dec 1992||Glaxo Inc.||Medical capsule device actuated by radio-frequency (rf) signal|
|US5316015 *||30 Jul 1992||31 May 1994||Sinaiko Robert J||Externally controlled intestinal content sampler|
|US5819749 *||22 Jul 1997||13 Oct 1998||Regents Of The University Of California||Microvalve|
|US7282045||27 Jun 2003||16 Oct 2007||Phaeton Research Ltd.||Ingestible device|
|US7763014||30 Jul 2007||27 Jul 2010||Phaeton Research Ltd.||Ingestible device|
|US8038646||14 Oct 2005||18 Oct 2011||Olympus Corporation||Body-insertable apparatus and manufacturing method thereof|
|US8414559||7 May 2009||9 Apr 2013||Rainbow Medical Ltd.||Gastroretentive duodenal pill|
|US8491495 *||30 Nov 2012||23 Jul 2013||L. Zane Shuck||Human intestinal tract research and diagnostic system to evaluate patients and advance medical science and bioengineering and to determine processes in the gut and causes of diseases|
|US8915863 *||28 Jun 2013||23 Dec 2014||L. Zane Shuck||In vivo device and method for researching GI tract processes, microbes, and variables associated with illnesses and diseases|
|US8926526 *||28 Jun 2013||6 Jan 2015||L. Zane Shuck||Patient in vivo gut diagnostic and treatment tool|
|US9078799 *||17 Sep 2007||14 Jul 2015||Vibrant Ltd.||Gastrointestinal capsule|
|US9215997 *||28 Jun 2013||22 Dec 2015||L. Zane Shuck||In vivo technology system for human gut research, diagnostics and treatment|
|US9220688 *||9 Apr 2010||29 Dec 2015||Slendine Sa||Device and method for reducing calorie intake|
|US9320715||7 May 2014||26 Apr 2016||Slendine Sa||Devices and methods for weight control and weight loss|
|US20040073018 *||27 Jun 2003||15 Apr 2004||Gravel Roy A.||Human methionine synthase: cloning, and methods for evaluating risk of neural tube defects, cardiovascular disease, and cancer|
|US20040253304 *||29 Jan 2004||16 Dec 2004||Yossi Gross||Active drug delivery in the gastrointestinal tract|
|US20040267240 *||3 May 2004||30 Dec 2004||Yossi Gross||Active drug delivery in the gastrointestinal tract|
|US20050058701 *||29 Jul 2004||17 Mar 2005||Yossi Gross||Active drug delivery in the gastrointestinal tract|
|US20050075559 *||27 Jun 2003||7 Apr 2005||Phaeton Research Ltd.||Ingestible device|
|US20060276844 *||18 May 2006||7 Dec 2006||Ruth Alon||Ingestible device for nitric oxide production in tissue|
|US20080188837 *||14 Dec 2005||7 Aug 2008||Ziv Belsky||Local Delivery of Drugs or Substances Using Electronic Permeability Increase|
|US20090318841 *||17 Sep 2007||24 Dec 2009||Vibrant Ltd.||Gastrointestinal capsule|
|US20100215733 *||9 Apr 2010||26 Aug 2010||Paolo Costa||Device and method for reducing calorie intake|
|US20100286587 *||7 May 2009||11 Nov 2010||Yossi Gross||Sublingual electrical drug delivery|
|US20140162305 *||28 Jun 2013||12 Jun 2014||L. Zane Shuck||Patient In Vivo Gut Diagnostic and Treatment Tool|
|US20140163416 *||28 Jun 2013||12 Jun 2014||L. Zane Shuck||In Vivo Device and Method for Researching GI Tract Processes, Microbes, and Variables Associated with Illnesses and Diseases|
|US20150112166 *||28 Jun 2013||23 Apr 2015||L. Zane Shuck||In Vivo Technology System for Human Gut Research, Diagnostics and Treatment|
|CN101039715B||14 Oct 2005||7 Dec 2011||奥林巴斯株式会社||可插入体内的装置及其制造方法|
|DE10161958A1 *||17 Dec 2001||3 Jul 2003||Universitaetsklinikum Freiburg||Surgical system for carrying out a non-invasive or minimal- invasive intervention has a miniature operation capsule that can be inserted in a blood vessel and remotely controlled or moved in a magnetic or electrical field|
|EP1627039A2 *||1 Apr 2004||22 Feb 2006||Mark M. Levy||Ingestible gastrointestinal device|
|EP1627039A4 *||1 Apr 2004||7 Nov 2012||Mark M Levy||Ingestible gastrointestinal device|
|EP2073779A4 *||17 Sep 2007||20 Jul 2016||Vibrant Ltd||Gastrointestinal capsule|
|WO1979000811A1 *||21 Mar 1979||18 Oct 1979||J Pawelec||Device for study of the alimentary canal|
|WO1987003465A1 *||8 Dec 1986||18 Jun 1987||Alain Lambert||Ingestable module for the functional exploration of the digestive tract|
|WO2006041222A3 *||14 Oct 2005||1 Jun 2006||Hironao Kawano||Body-insertable apparatus for aspirating and expelling body fluid and manufacturing method thereof|
|WO2014140334A1 *||14 Mar 2014||18 Sep 2014||Mars, Incorporated||Sampling device|
|U.S. Classification||600/582, 604/57|
|International Classification||A61B10/00, A61B5/07, A61B10/02, A61M37/00|
|Cooperative Classification||A61B2010/0061, A61B10/02, A61M37/00, A61B5/073|
|European Classification||A61M37/00, A61B10/02, A61B5/07B|