US3481109A - Container sterilising and filling apparatus - Google Patents

Container sterilising and filling apparatus Download PDF

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US3481109A
US3481109A US688150A US3481109DA US3481109A US 3481109 A US3481109 A US 3481109A US 688150 A US688150 A US 688150A US 3481109D A US3481109D A US 3481109DA US 3481109 A US3481109 A US 3481109A
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Prior art keywords
bottle
container
sterilising
sleeve
filling
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US688150A
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John Anthony Pavey
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National Research Development Corp UK
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National Research Development Corp UK
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02Sterilising, e.g. of complete packages
    • B65B55/04Sterilising wrappers or receptacles prior to, or during, packaging
    • B65B55/10Sterilising wrappers or receptacles prior to, or during, packaging by liquids or gases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65BMACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B55/00Preserving, protecting or purifying packages or package contents in association with packaging
    • B65B55/02Sterilising, e.g. of complete packages
    • B65B55/04Sterilising wrappers or receptacles prior to, or during, packaging
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B67OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67CCLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C7/00Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
    • B67C7/0006Conveying; Synchronising
    • B67C7/004Conveying; Synchronising the containers travelling along a circular path
    • B67C7/0046Infeed and outfeed devices

Definitions

  • bottle comprising a plurality of stations each of which includes a pedestal, a sleeve, a filling valve and a barrier member for isolating the filling valve from steam introduced into the sleeve to sterilise the bottle.
  • the sleeve is movable to allow the bottle to be raised within the sleeve to engage the filling valve.
  • the barrier member has associated with it jaws for gripping a bottle closure device on the bottle when it arrives at the station and for holding the closure device during sterilisation and for releasing the closure device on to the bottle neck after sterilisation and filling of the bottle.
  • This invention relates to apparatus for sterilising and filling a container in which the sterilising and filling is carried out at the same station.
  • Apparatus for sterilising and filling a container may include afilling valve which, when opened, delivers material from a reservoir into a previously sterilised container.
  • afilling valve which, when opened, delivers material from a reservoir into a previously sterilised container.
  • apparatus for sterilising and filling a container comprising means for sterilising a container at a station, a filling valve operable to fill the container at the station from a position above the container, and a barrier member movable in a substantially horizontal direction from one position between the container and the filling valve in which it isolates the filling valve for sterilising medium during the container sterilising operation and from atmospheric contamination during loading and unloading of the container to and from the station, to another position in which it allows the container to be filled from the filling valve.
  • the barrier member may be associated with means for holding a container closure device for sterilisation by the sterilising medium during the container sterilising operation.
  • the closure device may be fed to the barrier member along a path separate from that followed by the container in arriving at the station.
  • the closure device may be carried by the container as it arrives at the station and in this case the closure device would be removed from the container by the means associated with the barrier member, before sterilisation.
  • FIGURE 1 illustrates an elevational view of an apparatus for preheating, sterilising and filling a bottle with milk
  • FIGURE 2 illustrates a plan view of the apparatus illustrated in FIG. 1, with parts removed for the sake of clarity;
  • FIGURE 3 illustrates a sectional view in elevation of one of the sterilising and filling stations included in the apparatus illustrated in FIG. 1;
  • FIGURE 4 is a sectional view taken on the line IVIV in FIG. 3, illustrating parts in a first operational position
  • FIGURE 5 is a sectional view similar to that of FIG. 4 but with parts in another operational position;
  • FIGURE 6 illustrates an elevational view, partially in section of a portion of the apparatus illustrated in FIG. 1.
  • FIGURES 1 and 2 there is illustrated an apparatus for preheating, sterilising and filling bottles.
  • the apparatus is intended for filling bottles with milk but is suitable for filling the bottles with other liquids, such as, for example, liquid pharmaceuticals beverages or clear soups.
  • the apparatus comprises a base 1 on which is mounted a rotary preheating device 2 and a rotary, sterilising and filling device 3.
  • Bottles 4 to be preheated, sterilised and filled are fed along a conveyor 5 to a star-wheel 6, which when rotated loads bottles, in cooperation with the semi-circular guide 7, in series on to the rotary preheat device 2.
  • the bottles 4 are placed one in each of a plurality of preheat stations 8, in sequence.
  • Each preheat station 8 includes a pedestal 9 carried on the upper end of a vertically reciprocable shaft 9 driven in its vertical movement by means contained within the base 1; a sleeve 10 carried by a vertically reciprocable shaft 10 coaxial with the shaft 9 and driven in its vertical movement by means contained within the base 1; and a head 11.
  • the means for driving the shafts 9, 10 may be stationary cam tracks on which cam followers associated with the shafts bear, or, alternatively the shafts 9', 10' may be driven by pneumatic means.
  • the pedestal 9 is raised by its shaft 9' so that the mouth of the bottle is brought into forced engagement with a seal 12 which seals the bottle.
  • the sleeve 10 is then raised, about the bottle, until its upper end cooperates with a seal 13.
  • the sleeve 10 is also sealed at its lower end.
  • the sleeve 10 and pedestal 9 are lowered by the time the bottle arrives at a further star-wheel 15 which carries the bottle, in cooperation with a circular arcuate guide 16, away from the preheat device 2 to the sterilising and filling device 3.
  • a device located above the star wheel 15, places a closure device on the neck of each bottle as it passes beneath the device 100. The closure device is carried forward on the bottle.
  • the sterilising and filling device includes a plurality of stations 17 similar in certain respects to the stations 8 of the preheat device 2.
  • Each station 17 includes a pedestal 18 carried on the upper end of a vertically reciprocable shaft 18 driven in its vertical movement by means disposed within the base 1; a sleeve 19 carried by a vertically reciprocable shaft 19' coaxial with the shaft 18' and driven in its vertical movement by means disposed within the base 1; and a head 20.
  • the shafts 18', 19 may be driven by a stationary cam track on which earn followers associated with the shafts bear. Alternatively the shafts may be driven by pneumatic means.
  • the pedestals 18, sleeves 19 and heads 20 are rotatable in unison about a vertical axis by means disposed within the base 1.
  • the bottles are placed, by the starwheel 15, one on each of the pedestals 18 when the sleeve 19 around the pedestal 18 receiving a bottle is in its lowered position.
  • the sleeve 19 is then raised to its uppermost position (illustrated in FIG. 3) in which the upper end of the sleeve 19 cooperates with a seal 21.
  • the lower end of the sleeve 19 slides over a seal 22 and the vertical shaft of the pedestal 18 slides within a seal 23.
  • Each head 20 includes a filling valve 24, a barrier member 25 slidably mounted therein for movement in a substantially horizontal direction, and a conduit 26 for the passage of steam and air.
  • the filling valve 24 is located above the plane of the barrier member 25 and is generally coaxial with the pedestal 18 and sleeve 19.
  • the filling valve 24 includes a vertical steam 27 connected to an upper housing part 28 of the head.
  • the stem 27 has a frusto-conical face 29 at its lower end which engages a valve seat 30.
  • the stem 27 is mounted in a vertical passage 31 which is formed in part in the upper housing part 28, in part by a bellows 32, and in part by a valve sleeve 33.
  • the valve seat is formed on the lower extremity of the valve sleeve 33 and the arrangement of valve seat 30 and the stem face 29 is such that upon upwards movement of the valve sleeve 33 the lower end of the passage 31 is opened for fiow of liquid between the valve seat 30 and face 29.
  • the passage 31 is open at its upper end to the interior of a sterile reservoir 34 which rotates with the heads 20.
  • a spring 35 located coaxially with the stem 27 within the bellows 32 acts between the upper housing part 28 and the valve sleeve 33 to urge the sleeve 33 downwards into sealing engagement with the valve face 30 of the valve stem 27.
  • the sleeve 33 slides within a sealing ring 36.
  • a further sealing ring 37 is positioned below the valve sleeve 33 and rests on a ledge 38.
  • Each jaw 50, 51 Disposed on the underside of the barrier member 25 are two jaws 50, 51 of a container closure gripping device.
  • the jaws 50, 51 are pivotally connected to the barrier member 25 at pivots 52, 53 respectively.
  • Each jaw 50, 51 has an arcuate inner profile in plan (see FIGS. 4 and 5), as indicated at 54, so shaped that a container closure device, for example, a bottle cap 55, can be held between them.
  • the ends of the jaws 50, 51 remote from the pivots 52, 53 are pivotally connected at 56 to links 57, 58 and the links 57, 58 are connected through a common pivot 59 to a connecting rod 40.
  • a tension spring 60 biases the jaws 50, 51 towards one another.
  • the connecting rod 40 extends towards the axis of rotation of the sterilising and filling device 3, through seals 110 carried by the head.
  • the seals 110 serve to isolate the space within the head and sleeve from the atmosphere whilst allowing movement of the rod 40 into and out of this space.
  • the end of the rod 40 nearer the axis of rotation is connected by a vertical connecting link 41 to an upper rod 42 which is located above and parallel to the rod 40.
  • the upper rod 42 carries a cam follower in the form of two rollers 43, 44 extending into a radially extending slot 45 in the head and a roller 46 projecting into a cam track 47 in the underside of a member 48 which is stationary and does not rotate with the heads 20.
  • the rollers 43, 44 and slot 45 constrain the upper rod 42 for movement in a radial direction and the cam track 47 and roller 46 serve to move the upper rod 42, link 41 and rod 40 to and fro along the radius-in accordance with the predetermined form of the cam track 47, as the head rotates relative to the member 48.
  • the cam track 47 is continuous and varies, along its length, in radial distance from the axis of rotation, whereby the barrier member 25 may be in the position illustrated in FIG. 3 or in a position in which it extends beneath the filling valve and the jaws 50, 51 may be closed or open when the barrier member is in its position beneath the filling valve.
  • the barrier member 25 As the rod 40 is moved radially outwards from its position illustrated in FIG. 4 the barrier member 25 is moved in unison with the rod 40 through the links 57, 58, jaws 50, 51 and pivots 59, 56, 52, 53. The barrier member 25 is guided in such sliding movement by guides formed in the head. When the barrier member 25 is located beneath the filling valve the radially outer end of the barrier member 25 engages a stop 62 which prevents further radially outwards movement of the barrier member 25. Further radially outwards movement of the rod causes the jaws 50, 51 to be opened in opposition to the spring 60.
  • An annular seal 49 formed of a material which is not detrimentally affected by the elevated temperatures to be encountered or by sliding movement of the barrier member 25 over it is retained in the head coaxially with the filling valve and has a start which extends downwardly so as to engage the upper surface of the barrier member 25 when the latter is disposed beneath the filling valve.
  • the passage 26 extends from a space 65 beneath the path of the barrier member 25 to a head member 66 which engages and rotates, in unison with the heads 20, relative to the face of a lateral projection 67 from the non-rotating central portion of the apparatus.
  • the lateral projection 67 has formed in it passages (not shown) leading to parts (not shown) in the face thereof engaging the opposed face of the member "66. Steam is supplied to one of the passages and vacuum is applied to the other of the passages in the lateral projection 67.
  • the head member- 66 and lateral projection 67 function as a rotary valve controlling application of steam and vacuum to the passage 26 at appropriately timed intervals.
  • the vacuum may be created by any convenient means such as, for example, a vacuum pump or a steam ejector.
  • FIG- URE 6 illustrates such a coupling which is disposed within the casing 70 illustrated in FIG. 1.
  • the upper extremity of the reservoir 34 is provided with a neck 71 to which is affixed an annular collar 72, the upper surface of which is coplanar with the upper extremity of the neck 71.
  • the collar has a circumferential groove 73.
  • a supply conduit At end portion 74 of a supply conduit is disposed with its axis aligned with that of the neck 71 and has secured to its end a flange 75.
  • the flange 75 has a skirt 76 which extends downwardly as a sliding fit around the periphery of the collar 72 above the groove 73.
  • the skirt 76 has formed in it four apertures 77 uniformly disposed about the common axis of the neck 71 and conduit end portion 74 and the axis of the apertures 77 are parallel to the aforesaid common axis.
  • piston-cylinder devices 78 Four fluid pressure-operated piston-cylinder devices 78 are provided, the cylinder parts 79 of which are mounted on the flange 75 by screw-threaded engagement in the apertures 77. Lock nuts 80 are provided.
  • the piston parts of the devices 78 have rods 81 which project from flie cylinder parts 79 through the respective apertures 77.
  • a split ring 82, located in the groove 73 in the collar 72 has four apertures 83 therein thruogh each of which one of the piston rods 81 extends.
  • Each piston rod 81 is secured to the split ring 82 by two nuts 84, 85.
  • the flange 75 has a radial face 86 engageable in a sealing manner with a corresponding face 87 on the collar 72.
  • One of the faces 86, 87 has bonded to it a disc of Ulon to prevent metal to metal contact of the two faces.
  • the piston cylinder devices 78 are operated in-an extending manner which causes the faces 86, 87 to move apart bya small distance as indicated bythe lines A and B. Cleaning fluid can then be passed through the coupling so as toleak from the conduit end 74 radially outwardly between the faces 8'6, 87 thereby cleaning them.
  • the radially inner cylindrical surface of the skirt 76 is provided with grooves (not shown). Sterilisation of the coupling can be effected in a similar manner.
  • each sleeve' 10 is lowered, after venting of the steam.
  • the pedestal 9 is then lowered and the bottle 4 is then engaged by the star-wheel 15 and is moved,'whilst guided by the guide 16, towards the sterilising and filling device 3. Whilst being moved by the star wheel 15, a bottle 4 has placed on its neck a cap 55fromj the cap feed device 100.
  • the bottle 4 with a cap 55 thereon is placed by the stanwheel 15 on one of the pedestals 18 of the rotating sterilising and filling device 3.
  • the pedestal 18 is then raised.
  • the barrier member is, at this time disposed beneath the fillingvalveand it is in this position at all times when the sleeve 19 is lowered away from the seal 21, so that the underside of the filling valve is isolated from the atmosphere by the engagement of the barrier member 25 with the seal 49.
  • the fIhe pedestal 18 is raised until the cap 55 on the bottle engages the underside of the barrier member 25.
  • the jaws 50, 51 are at this time, open because the rod 40 has been moved fully radially outwards under the control of the cam track 47.
  • the connecting rod 40 moves radially inwards, under the control of the cam track 47, through a small distance to allow the jaws 50, 51 to close on and grip the cap 55 without radially inwards movement of the barrier member 25.
  • the pedestal 18 with the bottle thereon is then lowered and the cap stays behind in the jaws 50, 51.
  • the passage 26 has applied to it a vacuum. Since the passage 26 is in open communication through the space 65 with the interior of the sleeve, which includes the interior of the bottle because the interior of the bottle is not isolated. The interior of the sleeve is partially evacuated. Continued rotation of the head 20 moves the passage in the member 66 past the vacuum port in the lateral projection 67 to the steam port in the lateral projection 67.
  • the sterilising steam is prevented from reaching the underside of the filling valve by the cooperation of the seal 49 with the barrier member 25.
  • the seal 49 should fail when the interior of the sleeve 19 is partially evacuated, the seal 26 would prevent inflow of atmospheric air. If the seal 49 should fail when the interior of the sleeve contains sterilising steam, the seal 49, being of the U-sectional form illustrated, allows escape to the atmosphere of pressure steam in the cavity above the barrier member, so that a build up of steam pressure on the underside of the filling valve is prevented. Thus, even if the seal 49 should fail, contamination and adulteration of the'liquid to be introduced into the bottle 4 is prevented.
  • the steam supply through the passage 26 is subsequently cut off and the passage 26 is vented through the lateral projection 67.
  • the connecting rod 40 is then moved radially inwards, under the control of the cam track 47, and, because movement of the jaws 50, 51 towards one another is prevented by the presence of the cap 55 between the jaws, the barrier member 25 is moved radially inwards to its position illustrated in FIG. 4.
  • the pedestal 18 is then raised to a position in which the neck of the bottle 4 not only engages the seal 37 but lifts it upwardly into engagement with the sleeve 33 and moves the sleeve 33 upwardly, against the spring 35, so that the valve seat surface 30 moves away from the stern surface 29 so that liquid in the valve sleeve 33 and bellows 32 flows downwardly into the bottle.
  • Liquid flowing out of the sleeve 33 and bellows 32 is, of course, replenished by flow of liquid out of the reservoir 34 which in turn is replenished by flow from a further reservoir through the conduit end 74 and neck 71.
  • the pedestal 18 is lowered further until the upper end of the neck of the bottle is out of the path of the barrier member 25 and cap 55.
  • the barrier member 25, with the cap 55 still gripped in the jaws 50, 51 is moved radially outwards to a position in which the barrier member 25 is beneath the filling valve and contacts the stop 62.
  • the pedestal 18 is then raised. It will be realised that the space within the neck above the liquid in the bottle now contains residual steam and a little residual, sterilised air, assuming that the vacuum previously created was not a total vacuum.
  • the neck of the bottle is brought up into forced engagement with the cap by further upwards movement of the pedestal 18.
  • the connecting rod 40 is then moved further radially outwards so that the jaws 50, 51 move apart and release their grip on the cap 55, the barrier member 25 being in engagement with the stop 62 at this time.
  • the residual steam in the space beneath the cap 55, and within the bottle is condensing and hence the cap 55 is held on the bottle by a partial vacuum.
  • the pedestal 18 and sleeve 19 are then lowered, before arrival of the station 20 at the star-wheel 101 which moves the bottle 4, under the guidance of the guide 102, back on to the conveyor to a station (not shown) at which the cap is crimped on to the neck of the bottle.
  • the crimping station need not be provided if other means are provided for securing the cap to the bottle.
  • the bottle and cap are sterilised, the bottle is filled with liquid and the bottle is capped, all these operations occurring in a sterile atmosphere.
  • bottles are the containers to be sterilised and filled
  • the containers may be of other form, such as, for example, cans.
  • the terms filling, filled or the like are not to be construed as meaning that the container is to contain liquid or other material of a volume equivalent to the volume of the container. Rather, the terms are to be construed as meaning the introduction into the container of material having a volume which may be less than that of the container, in which case the container is not, literally speaking, filled.
  • the invention may be embodied in apparatus for sterilising and filling a container with materials other than liquids.
  • materials may, for example, be solids, for example, solids in powder, particulate or granular form.
  • the invention has been described in embodiments which are continuously operating and rotary acting, it is to be understood that the invention may be embodied in other arrangements.
  • Apparatus for sterilising and filling a container comprising:
  • a filling valve adapted to fill the container at the station
  • a barrier member adapted to be moved in a substantially horizontal direction from a first position between the container and the filling valve in which it isolates the filling valve from the sterilising medium during the container sterilising operation and from atmospheric contamination during loading and unloading of the container to and from the station, to a second position in which it allows the container to be filled from the filling valve.
  • a pedestal adapted 'to support a container to be sterilised and filled
  • a sleeve adapted to be moved between positions in one of which it allows loading and unloading of a container on and off the pedestal and in another of which it serves in part to isolate the container from the atmosphere;
  • Apparatus as claimed in claim 2 including:
  • closure device holding means being associated with said barrier member.
  • said closure device holding means is adapted to grip and hold a container closure device disposed on a container upon arrival at said station and subsequently to release the container closure device on to the container.
  • closure device holding means includes:
  • said station includes:
  • a pedestal adapted to support a container to be sterilised and filled
  • a sleeve adapted to be moved between positions in one of which it allows loading and unloading of a container on and off the pedestal and in another of which it serves, in part, to isolate the container from the atmosphere;
  • said station constitutes one of a plurality of similar stations disposed about and rotatable in unison about a vertical axis.
  • cam follower means engaging the cam track and connected to the barrier member.
  • cam follower means is connected to the said two closure device engaging members
  • said two closure device engaging members are pivotally connected to said barrier member

Description

Dec. 2, 1969 J A. PAVEY 3,481,109
CONTAINER STERILISING AND FILLING APPARATUS Filed Dec. 5, 1967 5 Sheets-Sheet 1.
Dec. 2,1969 J. A. PAVEY 3,481,109
CQNTAINER STERILiSING AND FILLING APPARATUS Filed Dec. 5, 1967 5 Sheets-Sheet 2 Dec, 2, 1969 J. A. PAVEY 3,481,109
CONTAINER STERILI SING AND FILLING APPARATUS Filed Dec. 5, 1967 5 Sheets-Sheet 4 Dec. 2', 1969 J. A. PAVEY 3,481,109
CONTAINER STERILISING AND FILLING APPARATUS 5 Sheets-Sheet 5 Filed Dec. 5, 1967 United States Patent 3,481,109 CONTAINER STERILISING AND FILLING APPARATUS John Anthony Pavey, Reading, England, assignor to National Research Development Corporation, London, England, a British corporation Filed Dec. 5, 1967, Ser. No. 688,150 Claims priority, application Great Britain, Dec. 8, 1966, 55,072/66, 55,073/66 Int. Cl. B67c 7/00 U.S. Cl. 53-167 15 Claims ABSTRACT OF THE DISCLOSURE Apparatus for sterilising and filling a container, e.g. bottle, comprising a plurality of stations each of which includes a pedestal, a sleeve, a filling valve and a barrier member for isolating the filling valve from steam introduced into the sleeve to sterilise the bottle. The sleeve is movable to allow the bottle to be raised within the sleeve to engage the filling valve. The barrier member has associated with it jaws for gripping a bottle closure device on the bottle when it arrives at the station and for holding the closure device during sterilisation and for releasing the closure device on to the bottle neck after sterilisation and filling of the bottle.
This invention relates to apparatus for sterilising and filling a container in which the sterilising and filling is carried out at the same station.
Apparatus for sterilising and filling a container may include afilling valve which, when opened, delivers material from a reservoir into a previously sterilised container. When sterilising the container, it is usually desirable to isolate the filling valve from the sterilising medium as, otherwise, the sterilising medium might contact and penetrate the filling valve and adulterate the material in the reservoir.
It is an object of the present invention to isolate the filling valve for sterilising medium and from atmospheric contamination.
According to the present invention there is provided apparatus for sterilising and filling a container, comprising means for sterilising a container at a station, a filling valve operable to fill the container at the station from a position above the container, and a barrier member movable in a substantially horizontal direction from one position between the container and the filling valve in which it isolates the filling valve for sterilising medium during the container sterilising operation and from atmospheric contamination during loading and unloading of the container to and from the station, to another position in which it allows the container to be filled from the filling valve.
The barrier member may be associated with means for holding a container closure device for sterilisation by the sterilising medium during the container sterilising operation. The closure device may be fed to the barrier member along a path separate from that followed by the container in arriving at the station. Alternatively, the closure device may be carried by the container as it arrives at the station and in this case the closure device would be removed from the container by the means associated with the barrier member, before sterilisation.
3,481,109 Patented Dec. 2, 1969 "ice Embodiments of the present invention will now be described, by way of example with reference to the accompanying drawings in which:
FIGURE 1 illustrates an elevational view of an apparatus for preheating, sterilising and filling a bottle with milk;
FIGURE 2 illustrates a plan view of the apparatus illustrated in FIG. 1, with parts removed for the sake of clarity;
FIGURE 3 illustrates a sectional view in elevation of one of the sterilising and filling stations included in the apparatus illustrated in FIG. 1;
FIGURE 4 is a sectional view taken on the line IVIV in FIG. 3, illustrating parts in a first operational position;
FIGURE 5 is a sectional view similar to that of FIG. 4 but with parts in another operational position;
FIGURE 6 illustrates an elevational view, partially in section of a portion of the apparatus illustrated in FIG. 1.
In FIGURES 1 and 2 there is illustrated an apparatus for preheating, sterilising and filling bottles. The apparatus is intended for filling bottles with milk but is suitable for filling the bottles with other liquids, such as, for example, liquid pharmaceuticals beverages or clear soups.
The apparatus comprises a base 1 on which is mounted a rotary preheating device 2 and a rotary, sterilising and filling device 3.
Bottles 4, to be preheated, sterilised and filled are fed along a conveyor 5 to a star-wheel 6, which when rotated loads bottles, in cooperation with the semi-circular guide 7, in series on to the rotary preheat device 2. The bottles 4 are placed one in each of a plurality of preheat stations 8, in sequence.
Each preheat station 8 includes a pedestal 9 carried on the upper end of a vertically reciprocable shaft 9 driven in its vertical movement by means contained within the base 1; a sleeve 10 carried by a vertically reciprocable shaft 10 coaxial with the shaft 9 and driven in its vertical movement by means contained within the base 1; and a head 11. The means for driving the shafts 9, 10 may be stationary cam tracks on which cam followers associated with the shafts bear, or, alternatively the shafts 9', 10' may be driven by pneumatic means.
After a bottle 4 has been placed on a pedestal 9, the pedestal 9 is raised by its shaft 9' so that the mouth of the bottle is brought into forced engagement with a seal 12 which seals the bottle. The sleeve 10 is then raised, about the bottle, until its upper end cooperates with a seal 13. The sleeve 10 is also sealed at its lower end.
Steam is then introduced, through a passage 14, into the space outside the bottle -4 within the sleeve 10. The steam serves to heat the bottle 4 so that upon subsequent sterilisation of the interior of the bottle by steam there is little or no condensation of the sterilising steam within the bottle.
After the bottle has been preheated the sleeve 10 and pedestal 9 are lowered by the time the bottle arrives at a further star-wheel 15 which carries the bottle, in cooperation with a circular arcuate guide 16, away from the preheat device 2 to the sterilising and filling device 3. A device located above the star wheel 15, places a closure device on the neck of each bottle as it passes beneath the device 100. The closure device is carried forward on the bottle.
The sterilising and filling device includes a plurality of stations 17 similar in certain respects to the stations 8 of the preheat device 2.
Each station 17 includes a pedestal 18 carried on the upper end of a vertically reciprocable shaft 18 driven in its vertical movement by means disposed within the base 1; a sleeve 19 carried by a vertically reciprocable shaft 19' coaxial with the shaft 18' and driven in its vertical movement by means disposed within the base 1; and a head 20. The shafts 18', 19 may be driven by a stationary cam track on which earn followers associated with the shafts bear. Alternatively the shafts may be driven by pneumatic means. The pedestals 18, sleeves 19 and heads 20 are rotatable in unison about a vertical axis by means disposed within the base 1. The bottles are placed, by the starwheel 15, one on each of the pedestals 18 when the sleeve 19 around the pedestal 18 receiving a bottle is in its lowered position. The sleeve 19 is then raised to its uppermost position (illustrated in FIG. 3) in which the upper end of the sleeve 19 cooperates with a seal 21. The lower end of the sleeve 19 slides over a seal 22 and the vertical shaft of the pedestal 18 slides within a seal 23.
Each head 20 includes a filling valve 24, a barrier member 25 slidably mounted therein for movement in a substantially horizontal direction, and a conduit 26 for the passage of steam and air.
The filling valve 24 is located above the plane of the barrier member 25 and is generally coaxial with the pedestal 18 and sleeve 19. The filling valve 24 includes a vertical steam 27 connected to an upper housing part 28 of the head. The stem 27 has a frusto-conical face 29 at its lower end which engages a valve seat 30.
The stem 27 is mounted in a vertical passage 31 which is formed in part in the upper housing part 28, in part by a bellows 32, and in part by a valve sleeve 33. The valve seat is formed on the lower extremity of the valve sleeve 33 and the arrangement of valve seat 30 and the stem face 29 is such that upon upwards movement of the valve sleeve 33 the lower end of the passage 31 is opened for fiow of liquid between the valve seat 30 and face 29. The passage 31 is open at its upper end to the interior of a sterile reservoir 34 which rotates with the heads 20.
A spring 35 located coaxially with the stem 27 within the bellows 32 acts between the upper housing part 28 and the valve sleeve 33 to urge the sleeve 33 downwards into sealing engagement with the valve face 30 of the valve stem 27.
The sleeve 33 slides within a sealing ring 36. A further sealing ring 37 is positioned below the valve sleeve 33 and rests on a ledge 38.
Disposed on the underside of the barrier member 25 are two jaws 50, 51 of a container closure gripping device. The jaws 50, 51 are pivotally connected to the barrier member 25 at pivots 52, 53 respectively. Each jaw 50, 51 has an arcuate inner profile in plan (see FIGS. 4 and 5), as indicated at 54, so shaped that a container closure device, for example, a bottle cap 55, can be held between them.
The ends of the jaws 50, 51 remote from the pivots 52, 53 are pivotally connected at 56 to links 57, 58 and the links 57, 58 are connected through a common pivot 59 to a connecting rod 40.
A tension spring 60 biases the jaws 50, 51 towards one another.
The connecting rod 40 extends towards the axis of rotation of the sterilising and filling device 3, through seals 110 carried by the head. The seals 110 serve to isolate the space within the head and sleeve from the atmosphere whilst allowing movement of the rod 40 into and out of this space. The end of the rod 40 nearer the axis of rotation is connected by a vertical connecting link 41 to an upper rod 42 which is located above and parallel to the rod 40. The upper rod 42 carries a cam follower in the form of two rollers 43, 44 extending into a radially extending slot 45 in the head and a roller 46 projecting into a cam track 47 in the underside of a member 48 which is stationary and does not rotate with the heads 20. The rollers 43, 44 and slot 45 constrain the upper rod 42 for movement in a radial direction and the cam track 47 and roller 46 serve to move the upper rod 42, link 41 and rod 40 to and fro along the radius-in accordance with the predetermined form of the cam track 47, as the head rotates relative to the member 48. The cam track 47 is continuous and varies, along its length, in radial distance from the axis of rotation, whereby the barrier member 25 may be in the position illustrated in FIG. 3 or in a position in which it extends beneath the filling valve and the jaws 50, 51 may be closed or open when the barrier member is in its position beneath the filling valve.
As the rod 40 is moved radially outwards from its position illustrated in FIG. 4 the barrier member 25 is moved in unison with the rod 40 through the links 57, 58, jaws 50, 51 and pivots 59, 56, 52, 53. The barrier member 25 is guided in such sliding movement by guides formed in the head. When the barrier member 25 is located beneath the filling valve the radially outer end of the barrier member 25 engages a stop 62 which prevents further radially outwards movement of the barrier member 25. Further radially outwards movement of the rod causes the jaws 50, 51 to be opened in opposition to the spring 60. An annular seal 49 formed of a material which is not detrimentally affected by the elevated temperatures to be encountered or by sliding movement of the barrier member 25 over it is retained in the head coaxially with the filling valve and has a start which extends downwardly so as to engage the upper surface of the barrier member 25 when the latter is disposed beneath the filling valve.
The passage 26 extends from a space 65 beneath the path of the barrier member 25 to a head member 66 which engages and rotates, in unison with the heads 20, relative to the face of a lateral projection 67 from the non-rotating central portion of the apparatus. The lateral projection 67 has formed in it passages (not shown) leading to parts (not shown) in the face thereof engaging the opposed face of the member "66. Steam is supplied to one of the passages and vacuum is applied to the other of the passages in the lateral projection 67. The head member- 66 and lateral projection 67 function as a rotary valve controlling application of steam and vacuum to the passage 26 at appropriately timed intervals.
The vacuum may be created by any convenient means such as, for example, a vacuum pump or a steam ejector.
As mentioned above, the reservoir 34 rotates with the heads 20. Since it is necessary that the liquid, for example milk, to be placed in the containers should be maintained in a sterile condition, the liquid must be supplied to the reservoir along a path isolated from the atmosphere. It is therefore necessary to provide a connection between a non-rotating reservoir and the rotating reservoir 34. FIG- URE 6 illustrates such a coupling which is disposed within the casing 70 illustrated in FIG. 1.
The upper extremity of the reservoir 34 is provided with a neck 71 to which is affixed an annular collar 72, the upper surface of which is coplanar with the upper extremity of the neck 71. The collar has a circumferential groove 73.
At end portion 74 of a supply conduit is disposed with its axis aligned with that of the neck 71 and has secured to its end a flange 75. The flange 75 has a skirt 76 which extends downwardly as a sliding fit around the periphery of the collar 72 above the groove 73.
The skirt 76 has formed in it four apertures 77 uniformly disposed about the common axis of the neck 71 and conduit end portion 74 and the axis of the apertures 77 are parallel to the aforesaid common axis.
Four fluid pressure-operated piston-cylinder devices 78 are provided, the cylinder parts 79 of which are mounted on the flange 75 by screw-threaded engagement in the apertures 77. Lock nuts 80 are provided. The piston parts of the devices 78 have rods 81 which project from flie cylinder parts 79 through the respective apertures 77. A split ring 82, located in the groove 73 in the collar 72 has four apertures 83 therein thruogh each of which one of the piston rods 81 extends. Each piston rod 81 is secured to the split ring 82 by two nuts 84, 85.
The flange 75 has a radial face 86 engageable in a sealing manner with a corresponding face 87 on the collar 72. One of the faces 86, 87 has bonded to it a disc of Ulon to prevent metal to metal contact of the two faces.
When the four piston cylinder devices 78 are operated in a contracting; manner, the faces 15, 16 are biased into forced surface 86 to surface 87 engagement and leakage of liquid between the faces 86, 87 from the conduit end 74 is prevent but rotation of the reservoir 34 and neck 71 and collar 72 relative to the conduit end 74 and flange 75 is possible. During this relative rotational movement the surface 87 slides over the surface 86 and surfaces of the groove 73 slide over surfaces of the split ring 82.
To clean the coupling, the piston cylinder devices 78 are operated in-an extending manner which causes the faces 86, 87 to move apart bya small distance as indicated bythe lines A and B. Cleaning fluid can then be passed through the coupling so as toleak from the conduit end 74 radially outwardly between the faces 8'6, 87 thereby cleaning them. In order to allow fluid to escape from the radially outer periphery of the faces 86, 87, the radially inner cylindrical surface of the skirt 76 is provided with grooves (not shown). Sterilisation of the coupling can be effected in a similar manner.
The seal between the conduit end 74 and the neck 71 is re -created by operating the piston-cylinder units in a contracting'manner. In operation of the apparatus, a series'of bottles 4 are supplied along-the conveyor 5 and, in single succession, are engaged by the star-wheel 6 and carried round thereby, guided by the guide 7 and placed one on each of the pedestals 9.'After passing away from the star-wheel 5, the sleeve 10 associated with the pedestal 9 on which a bottle 4 has just been placed, is raised so that its upper end engages the seal 13. As the preheating device 2 continues to rotate, the-pedestal9 is raised so that the neck of the bottle 4 engages the seal 12 and the interior of the bottle 4 is isolated from-the now enclosed interior of the sleeve 10. After the isolation of the interior of the bottle, steam is introducedinto the enclosed interior of the sleeve 10 through the passagei14. No steam enters the isolated interior of the bottle 4.It is arranged that the rate of rotation of the pie-heat device is such that before the bottle has to leave the pre-heat device 2, the bottle 4 is sufficiently heated that upon subsequent introduction of steam into the bottle there is substantially no condensa- 'tion within the bottle.
As the individual bottles 4 approach the star-wheel 15, each sleeve' 10 is lowered, after venting of the steam. The pedestal 9 is then lowered and the bottle 4 is then engaged by the star-wheel 15 and is moved,'whilst guided by the guide 16, towards the sterilising and filling device 3. Whilst being moved by the star wheel 15, a bottle 4 has placed on its neck a cap 55fromj the cap feed device 100.
The bottle 4 with a cap 55 thereon is placed by the stanwheel 15 on one of the pedestals 18 of the rotating sterilising and filling device 3. As the station 17 with the newly preheated bottle 4 thereon moves away from the star-wheellS, the sleeve 19 is raised so that its upper end engages the seal-=21. The pedestal 18 is then raised. The barrier member is, at this time disposed beneath the fillingvalveand it is in this position at all times when the sleeve 19 is lowered away from the seal 21, so that the underside of the filling valve is isolated from the atmosphere by the engagement of the barrier member 25 with the seal 49.
fIhe pedestal 18 is raised until the cap 55 on the bottle engages the underside of the barrier member 25. The jaws 50, 51 are at this time, open because the rod 40 has been moved fully radially outwards under the control of the cam track 47. When the cap 55 has been brought up to the underside of the barrier member 25 the connecting rod 40 moves radially inwards, under the control of the cam track 47, through a small distance to allow the jaws 50, 51 to close on and grip the cap 55 without radially inwards movement of the barrier member 25.
The pedestal 18 with the bottle thereon is then lowered and the cap stays behind in the jaws 50, 51. At this stage in the rotation of the head 20 and hence of the member 66 relative to the lateral projection 67, the passage 26 has applied to it a vacuum. Since the passage 26 is in open communication through the space 65 with the interior of the sleeve, which includes the interior of the bottle because the interior of the bottle is not isolated. The interior of the sleeve is partially evacuated. Continued rotation of the head 20 moves the passage in the member 66 past the vacuum port in the lateral projection 67 to the steam port in the lateral projection 67.
In passing between the two ports the partial vacuum within the sleeve 19 is maintained. Steam is introduced into the interior of the sleeve 19 and bottle 4. Because of the partial vacuum, steam is able to contact and sterilise all parts of the interior and neck of the bottle and of the cap 55 without the masking effect which the presence of air at atmospheric pressure would otherwise create. The bottle and cap are thereby sterilised and because the bottle 4 is preheated there is substantially no condensation of the sterilising steam within the bottle 4.
The sterilising steam is prevented from reaching the underside of the filling valve by the cooperation of the seal 49 with the barrier member 25.
If the seal 49 should fail when the interior of the sleeve 19 is partially evacuated, the seal 26 would prevent inflow of atmospheric air. If the seal 49 should fail when the interior of the sleeve contains sterilising steam, the seal 49, being of the U-sectional form illustrated, allows escape to the atmosphere of pressure steam in the cavity above the barrier member, so that a build up of steam pressure on the underside of the filling valve is prevented. Thus, even if the seal 49 should fail, contamination and adulteration of the'liquid to be introduced into the bottle 4 is prevented.
The steam supply through the passage 26 is subsequently cut off and the passage 26 is vented through the lateral projection 67.
The connecting rod 40 is then moved radially inwards, under the control of the cam track 47, and, because movement of the jaws 50, 51 towards one another is prevented by the presence of the cap 55 between the jaws, the barrier member 25 is moved radially inwards to its position illustrated in FIG. 4. v
The pedestal 18 is then raised to a position in which the neck of the bottle 4 not only engages the seal 37 but lifts it upwardly into engagement with the sleeve 33 and moves the sleeve 33 upwardly, against the spring 35, so that the valve seat surface 30 moves away from the stern surface 29 so that liquid in the valve sleeve 33 and bellows 32 flows downwardly into the bottle. Liquid flowing out of the sleeve 33 and bellows 32 is, of course, replenished by flow of liquid out of the reservoir 34 which in turn is replenished by flow from a further reservoir through the conduit end 74 and neck 71.
The pedestal is then lowered and the spring 35 causes the valve sleeve 33 and seal 37 to follow the neck downwardly whilst maintaining a seal with the neck of the bottle thereby preventing spillage of liquid to the exterior of the bottle. Y I
Downwards movement of the valve sleeve 33 is terminated by engagement of the valve seat surface 30 with the stem surface 29 which also prevents further downwards flow of liquid. It will be realised that because the stem 27 extends beneath the stem surface 29 into the neck of the bottle 4, the volume of liquid in the bottle is slightly less than the volume of the bottle.
The pedestal 18 is lowered further until the upper end of the neck of the bottle is out of the path of the barrier member 25 and cap 55. The barrier member 25, with the cap 55 still gripped in the jaws 50, 51, is moved radially outwards to a position in which the barrier member 25 is beneath the filling valve and contacts the stop 62. The pedestal 18 is then raised. It will be realised that the space within the neck above the liquid in the bottle now contains residual steam and a little residual, sterilised air, assuming that the vacuum previously created was not a total vacuum. The neck of the bottle is brought up into forced engagement with the cap by further upwards movement of the pedestal 18. The connecting rod 40 is then moved further radially outwards so that the jaws 50, 51 move apart and release their grip on the cap 55, the barrier member 25 being in engagement with the stop 62 at this time.
The residual steam in the space beneath the cap 55, and within the bottle is condensing and hence the cap 55 is held on the bottle by a partial vacuum. The pedestal 18 and sleeve 19 are then lowered, before arrival of the station 20 at the star-wheel 101 which moves the bottle 4, under the guidance of the guide 102, back on to the conveyor to a station (not shown) at which the cap is crimped on to the neck of the bottle. The crimping station need not be provided if other means are provided for securing the cap to the bottle.
Thus, at the same station, the bottle and cap are sterilised, the bottle is filled with liquid and the bottle is capped, all these operations occurring in a sterile atmosphere.
Whilst it has been stated above in relation to the specific embodiments that bottles are the containers to be sterilised and filled, it is to be understood that the containers may be of other form, such as, for example, cans.
It is also to be understood that the terms filling, filled or the like, are not to be construed as meaning that the container is to contain liquid or other material of a volume equivalent to the volume of the container. Rather, the terms are to be construed as meaning the introduction into the container of material having a volume which may be less than that of the container, in which case the container is not, literally speaking, filled.
Whilst the material to be introduced into the containers is described above as liquid, and in particular milk, the invention may be embodied in apparatus for sterilising and filling a container with materials other than liquids. Such other materials may, for example, be solids, for example, solids in powder, particulate or granular form. Whilst the invention has been described in embodiments which are continuously operating and rotary acting, it is to be understood that the invention may be embodied in other arrangements.
I claim:
1. Apparatus for sterilising and filling a container comprising:
a station;
means adapted to sterilise a container at the station;
a filling valve adapted to fill the container at the station; and
a barrier member adapted to be moved in a substantially horizontal direction from a first position between the container and the filling valve in which it isolates the filling valve from the sterilising medium during the container sterilising operation and from atmospheric contamination during loading and unloading of the container to and from the station, to a second position in which it allows the container to be filled from the filling valve.
2. Apparatus as claimed in claim 1, wherein said station includes:
a pedestal adapted 'to support a container to be sterilised and filled;
a sleeve adapted to be moved between positions in one of which it allows loading and unloading of a container on and off the pedestal and in another of which it serves in part to isolate the container from the atmosphere; and
means adapted to introduce sterilising medium into the space Within the sleeve.
3. Apparatus as claimed in claim 2, including:
means adapted to evacuate the space within the sleeve prior to introduction of the sterilising medium.
4. Apparatus as claimed in claim 2, including:
means adapted to vent the sterilising medium from the space within the sleeve after sterilisation of the container; and
means adapted to move the barrier member into its said second position after venting of the sterilising medium, and to move the barrier member into its first position prior to unloading of the container.
5. Apparatus as claimed in claim 1, including:
means adapted to hold a container closure device;
said closure device holding means being associated with said barrier member.
6. Apparatus as claimed in claim 5, wherein:
said closure device holding means is adapted to grip and hold a container closure device disposed on a container upon arrival at said station and subsequently to release the container closure device on to the container.
7. Apparatus as claimed in claim 6, wherein said closure device holding means includes:
two members each adapted to engage a portion of the periphery of a closure device; and
means adapted to move the two members apart to release the closure device.
8. Apparatus as claimed in claim 7, wherein said station includes:
a pedestal adapted to support a container to be sterilised and filled;
a sleeve adapted to be moved between positions in one of which it allows loading and unloading of a container on and off the pedestal and in another of which it serves, in part, to isolate the container from the atmosphere; and
means adapted to introduce sterilising medium into the space within the sleeve.
9. Apparatus as claimed in claim 7, including:
means adapted to evacuate the space within the sleeve prior to introduction of the sterilising medium.
10. Apparatus as claimed in claim 9, including:
means adapted to vent the sterilising medium from the space within the sleeve after sterilisation of the container; and
means adapted to move the barrier member into its said second position after venting of the sterilising medium, and to move the barrier member into its first position prior to unloading of the container.
11. Apparatus as claimed in claim 10, wherein:
said station constitutes one of a plurality of similar stations disposed about and rotatable in unison about a vertical axis.
12. Apparatus as claimed in claim 11, wherein the means for moving each barrier member includes:
a stationary cam track; and
cam follower means engaging the cam track and connected to the barrier member.
13. Apparatus as claimed in claim 12, wherein:
said cam follower means is connected to the said two closure device engaging members;
said two closure device engaging members are pivotally connected to said barrier member;
the arrangement being such that initial movement in one direction of said cam follower means causes movement of the barrier member to its first position and that further movement in the said one direction of the cam follower means causes the two closure device engaging members to release a container closure device. w
14. Apparatus as claimed in claim 1, including:
a pre-heat station;
means adapted to load containers in series on said preheat station;
means adapted to unload containers from said pre-heat station and to load pre-heated containers in series on said sterilising and filling station;
means adapted to place a container closure device on 10 each container as it is moved from the pre-heat station to the sterilising and filling station; and
means adapted to unload filled containers from the sterilising and filling station.
15. Apparatus as claimed in claim 14, including:
10 means adapted to secure a container closure device to the container after the container with the closure device thereon is unloaded from the sterilising and filling station.
References Cited UNITED STATES PATENTS 10/1962 Palma 53167 7/1968 Burton et al. 141-85 X TRAVIS S. MCGEHEE, Primary Examiner
US688150A 1966-12-08 1967-12-05 Container sterilising and filling apparatus Expired - Lifetime US3481109A (en)

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3782878A (en) * 1972-03-14 1974-01-01 Campbell Soup Co Rotary extruder and loader
US4573486A (en) * 1983-03-31 1986-03-04 Krones Ag Hermann Kronseder Maschinenfabrik Device for cleaning container filling machines
US4862672A (en) * 1988-05-03 1989-09-05 Lane Sr William A Segmented head seal for cup packaging machine
US4981649A (en) * 1988-03-25 1991-01-01 Snow Brand Milk Products Co., Ltd. Means for lid sterilization and temporal sealing
US5267591A (en) * 1991-03-08 1993-12-07 Shikoku Kakoki Co., Ltd. Device for preventing condensation of water vapor on filling nozzle for use in filling apparatus
US5848515A (en) * 1995-08-11 1998-12-15 Rossi & Catelli S.P.A. Continuous-cycle sterile bottling plant
WO2001037886A1 (en) * 1999-11-22 2001-05-31 Krones Ag Method and device for sterilisation of packaging containers
US9321621B2 (en) 2010-05-25 2016-04-26 Otsuka Pharmaceutical Co., Ltd. Aseptic filling system
US20160324995A1 (en) * 2014-01-24 2016-11-10 Pierre Fabre Dermo-Cosmetique Device and method for transferring a sterile product between two containers
US20170073208A1 (en) * 2014-05-07 2017-03-16 Khs Gmbh Filling apparatus

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058276A (en) * 1960-12-29 1962-10-16 James R Palma Bottle washing, filling, capping and sterilizing device
US3393491A (en) * 1964-10-30 1968-07-23 Nat Res Dev Method and apparatus for sterilizing and filling bottles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3058276A (en) * 1960-12-29 1962-10-16 James R Palma Bottle washing, filling, capping and sterilizing device
US3393491A (en) * 1964-10-30 1968-07-23 Nat Res Dev Method and apparatus for sterilizing and filling bottles

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3782878A (en) * 1972-03-14 1974-01-01 Campbell Soup Co Rotary extruder and loader
US4573486A (en) * 1983-03-31 1986-03-04 Krones Ag Hermann Kronseder Maschinenfabrik Device for cleaning container filling machines
US4981649A (en) * 1988-03-25 1991-01-01 Snow Brand Milk Products Co., Ltd. Means for lid sterilization and temporal sealing
US4862672A (en) * 1988-05-03 1989-09-05 Lane Sr William A Segmented head seal for cup packaging machine
US5267591A (en) * 1991-03-08 1993-12-07 Shikoku Kakoki Co., Ltd. Device for preventing condensation of water vapor on filling nozzle for use in filling apparatus
US5848515A (en) * 1995-08-11 1998-12-15 Rossi & Catelli S.P.A. Continuous-cycle sterile bottling plant
WO2001037886A1 (en) * 1999-11-22 2001-05-31 Krones Ag Method and device for sterilisation of packaging containers
US9321621B2 (en) 2010-05-25 2016-04-26 Otsuka Pharmaceutical Co., Ltd. Aseptic filling system
US20160324995A1 (en) * 2014-01-24 2016-11-10 Pierre Fabre Dermo-Cosmetique Device and method for transferring a sterile product between two containers
US10646601B2 (en) * 2014-01-24 2020-05-12 Pierre Fabre Dermo-Cosmetique Device and method for transferring a sterile product between two containers
US20170073208A1 (en) * 2014-05-07 2017-03-16 Khs Gmbh Filling apparatus
US10472217B2 (en) * 2014-05-07 2019-11-12 Khs Gmbh Filling apparatus

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