US3025991A - Bottle stopper - Google Patents

Bottle stopper Download PDF

Info

Publication number
US3025991A
US3025991A US31086A US3108660A US3025991A US 3025991 A US3025991 A US 3025991A US 31086 A US31086 A US 31086A US 3108660 A US3108660 A US 3108660A US 3025991 A US3025991 A US 3025991A
Authority
US
United States
Prior art keywords
stopper
bottle
vial
resilient
bottle stopper
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
US31086A
Inventor
James H Gillon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CARRON PRODUCTS Co
Original Assignee
CARRON PRODUCTS CO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CARRON PRODUCTS CO filed Critical CARRON PRODUCTS CO
Priority to US31086A priority Critical patent/US3025991A/en
Application granted granted Critical
Publication of US3025991A publication Critical patent/US3025991A/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00Closures not otherwise provided for
    • B65D51/24Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/241Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes provided with freeze-drying means

Definitions

  • the invention relates to resilient stoppers for use with bottles or vials, which are or may be used for various types of parenteral solutions or the like. It relates particularly to a resilient stopper possessing particular configurations that render it satisfactory for application to bottles or vials either by hand or by automatic stoppering machines.
  • An additional object of my invention is to provide a resilient bottle or vial stopper having a membrane which may be readily pierced by a hypodermic needle or the like, when the product is to be administered and which will re-seal subsequently to prevent contamination of that portion of the product remaining in the bottle or vial.
  • a resilient stopper with a substantially cylindrical plug or body portion of a larger diameter than the neck opening in the bottle or "ial with which the stopper will be used; with a flange or head extending from the outer end of the stopper to afford a surface for effectively sealing the bottle or vial by the application of an aluminum seal or other standard type of seal.
  • Such seals are well known to those skilled in the art.
  • Another important object of the invention is to provide a stopper with one or more ribs on the plug portion thereof, which ribs may be uniformly or irregularly spaced and of the same or lesser diameter and thickness. Such ribs may be used as stops to control the depth of insertion of the stopper into the bottle or vial, thereby controlling the size of the opening afforded to permit the flow of gases in processing or the speed of evacuation prior to full insertion of the stopper to close the bottle or vial.
  • Further object of the invention is to provide a resilient, readily compressible stopper for bottles or vials with an opening in one side of the cylindrical plug portion which, when partially inserted, will permit the free flow of air into or from the container.
  • FIG. 1 is a perspective view of a stopper embodying my invention in one form
  • FIG. 2 is a View fragmentarily showing a bottle or vial in section with a stopper of FIG. 1 in place and in elevation;
  • FIG. 3 is a section taken as indicated by the angled arrows III-III in FIG. 2 with a stopper partly withdrawn;
  • FIG. 4 is a cross section taken as indicated by the angled arrows IV-IV in FIG. 3;
  • FIG. 5 is a perspective View of a modified form of the stopper.
  • FIG. 6 is a view similar to FIG. 3 showing the modified stopper partially inserted into the bottle or vial.
  • the stopper of my invention in the form there illustrated is comprehensively designated by the numeral 10. It is to be understood that the stopper is molded or otherwise fashioned in practice, of rubber or other suitably resilient material. As shown, the stopper 10 has a flat head 11 and a generally cylindrical plug portion 12 of smaller diameter pendent from said head, said plug portion having a relatively narrow radial slot 13 with flared or splayed sides extending vertically from the bottom of the plug portion to said head, and horizontally to an appropriate distance into one side of said plug portion but sufficiently short of the other side to avoid weakening the opposite wall area.
  • the body portion 12 of the stopper is provided with an uneven number (in this instance 3) of spaced circumferential beads or ridges 15 and its bottom edge is rounded or beveled ofi as at 16.
  • the diameters of the body portion 12 of the stopper and of the ridges 15 are somewhat larger than the internal diameter of the neck N of the bottle B, however, so as to engage tightly into the neck with a tight compression fit, and with the flange projection of the head 11 bearing fluid seal tight against the month top of the bottle or vial.
  • the stopper 15 is partially inserted for exposure of the portion of the side vent slot 13 above the bottle mouth with one or the other of the circumferential ridges 15 stopped against the top of the bottle mouth as instanced in FIG. 3.
  • the mid-ridge of the group 15 is used to limit the extent to which the stopper is inserted during lyophilizing, or freezing, or drying of pharmaceutical biologicals or other products with which the bottle or vial is filled. It is to be noted that the thickness of the membrane between the top of the cap and the hollow 13 of the plug portion 12 is such that it is easily penetrated by a hypodermic needle when some or all of the contents of the bottle or vial are to be withdrawn. It is to be further noted that the flaring or splaying of the sides of slot is advantageous in that it does not impede outward flow of the gases or vapors from the bottle or vial.
  • Modified stopper illustrated in FIGS. 5 and 6 differs from the first described form only in that the mid-ridge 15a on the plug is thicker and larger in diameter than the other ridges. Therefore, in order to obviate the necessity for repetitive description, all of the other elements in the modification having their counterparts in the first described embodiment have been identified by the same reference numerals previously used with addition, however, in each instance of the letter a for convenience of more ready distinction.
  • a bottle stopper of resilient material having a flat circular head, and a coaxial pendent cylindrical plug extension adapted to engage into the mouth of the bottle with a compression fit, said extension having a radial slot which flares outwardly from the center of the stopper and terminates short of the head, and being provided with at least three outwardly projecting circumferential stop ribs for selective engagement with the top of the bottle mouth to determine different positions of insertion for the stopper.
  • a bottle stopper characterized as in claim 1, in which the ribs are three in number and of which ribs the center one of the group is wider and projects outwardly to a greater extent than the others.

Description

March 1962 H. GILL-ON 3,025,991
BOTTLE STOPPER Filed May 23, 1960 FICr'zl INVEIYTOR. James 19? 67/1017,
BY 62.]: Q!
3,025,991 BOTTLE STOPPER James H. Gillon, Bala Cynwyd, Pa., assignor to Carron Products Co., Philadelphia, Pa., a firm Filed May 23, 1960, Ser. No. 31,086 2 Claims. (Cl. 215-56) The invention relates to resilient stoppers for use with bottles or vials, which are or may be used for various types of parenteral solutions or the like. It relates particularly to a resilient stopper possessing particular configurations that render it satisfactory for application to bottles or vials either by hand or by automatic stoppering machines.
It is an object of my invention to provide a resilient stopper especially suitable for facilitating evacuation of gases or vapors from bottles or vials developed during the lyophilizing, or freeze-drying of pharmaceutical, biological or other products produced by this method of manufacture.
An additional object of my invention is to provide a resilient bottle or vial stopper having a membrane which may be readily pierced by a hypodermic needle or the like, when the product is to be administered and which will re-seal subsequently to prevent contamination of that portion of the product remaining in the bottle or vial.
Other objects of the invention are to provide a resilient stopper with a substantially cylindrical plug or body portion of a larger diameter than the neck opening in the bottle or "ial with which the stopper will be used; with a flange or head extending from the outer end of the stopper to afford a surface for effectively sealing the bottle or vial by the application of an aluminum seal or other standard type of seal. Such seals are well known to those skilled in the art.
Another important object of the invention is to provide a stopper with one or more ribs on the plug portion thereof, which ribs may be uniformly or irregularly spaced and of the same or lesser diameter and thickness. Such ribs may be used as stops to control the depth of insertion of the stopper into the bottle or vial, thereby controlling the size of the opening afforded to permit the flow of gases in processing or the speed of evacuation prior to full insertion of the stopper to close the bottle or vial.
Further object of the invention is to provide a resilient, readily compressible stopper for bottles or vials with an opening in one side of the cylindrical plug portion which, when partially inserted, will permit the free flow of air into or from the container.
Other objects and attendant advantages will appear from the following detailed description of the attached drawings, wherein:
FIG. 1 is a perspective view of a stopper embodying my invention in one form;
FIG. 2 is a View fragmentarily showing a bottle or vial in section with a stopper of FIG. 1 in place and in elevation;
FIG. 3 is a section taken as indicated by the angled arrows III-III in FIG. 2 with a stopper partly withdrawn;
FIG. 4 is a cross section taken as indicated by the angled arrows IV-IV in FIG. 3;
FIG. 5 is a perspective View of a modified form of the stopper; and
FIG. 6 is a view similar to FIG. 3 showing the modified stopper partially inserted into the bottle or vial.
With more detailed reference first to FIGS. 1-4 of these drawings, the stopper of my invention in the form there illustrated is comprehensively designated by the numeral 10. It is to be understood that the stopper is molded or otherwise fashioned in practice, of rubber or other suitably resilient material. As shown, the stopper 10 has a flat head 11 and a generally cylindrical plug portion 12 of smaller diameter pendent from said head, said plug portion having a relatively narrow radial slot 13 with flared or splayed sides extending vertically from the bottom of the plug portion to said head, and horizontally to an appropriate distance into one side of said plug portion but sufficiently short of the other side to avoid weakening the opposite wall area. As shown further, the body portion 12 of the stopper is provided with an uneven number (in this instance 3) of spaced circumferential beads or ridges 15 and its bottom edge is rounded or beveled ofi as at 16. The diameters of the body portion 12 of the stopper and of the ridges 15 are somewhat larger than the internal diameter of the neck N of the bottle B, however, so as to engage tightly into the neck with a tight compression fit, and with the flange projection of the head 11 bearing fluid seal tight against the month top of the bottle or vial. For release of air or gases from the bottle, the stopper 15 is partially inserted for exposure of the portion of the side vent slot 13 above the bottle mouth with one or the other of the circumferential ridges 15 stopped against the top of the bottle mouth as instanced in FIG. 3. Ordinarily, the mid-ridge of the group 15 is used to limit the extent to which the stopper is inserted during lyophilizing, or freezing, or drying of pharmaceutical biologicals or other products with which the bottle or vial is filled. It is to be noted that the thickness of the membrane between the top of the cap and the hollow 13 of the plug portion 12 is such that it is easily penetrated by a hypodermic needle when some or all of the contents of the bottle or vial are to be withdrawn. It is to be further noted that the flaring or splaying of the sides of slot is advantageous in that it does not impede outward flow of the gases or vapors from the bottle or vial.
Modified stopper illustrated in FIGS. 5 and 6 differs from the first described form only in that the mid-ridge 15a on the plug is thicker and larger in diameter than the other ridges. Therefore, in order to obviate the necessity for repetitive description, all of the other elements in the modification having their counterparts in the first described embodiment have been identified by the same reference numerals previously used with addition, however, in each instance of the letter a for convenience of more ready distinction.
Having thus described my invention, I claim:
1. As a new product of manufacture, a bottle stopper of resilient material having a flat circular head, and a coaxial pendent cylindrical plug extension adapted to engage into the mouth of the bottle with a compression fit, said extension having a radial slot which flares outwardly from the center of the stopper and terminates short of the head, and being provided with at least three outwardly projecting circumferential stop ribs for selective engagement with the top of the bottle mouth to determine different positions of insertion for the stopper.
2. A bottle stopper characterized as in claim 1, in which the ribs are three in number and of which ribs the center one of the group is wider and projects outwardly to a greater extent than the others.
References Cited in the file of this patent UNITED STATES PATENTS 2,927,709 Hoffman et a1. Mar. 8, 1960 2,940,627 Schultz June 14, 1960 FOREIGN PATENTS 729,903 Great Britain May 11, 1955 1,200,415 France Dec. 21, 1959 UNITED STATES PATENT OFFICE CERTIFICATE OF CORRECTION Patent No. 3,025,991 March 20, 1962 I James H. Gillon It is hereby certified that error appears in the above numbered patent requiring correction and that the said Letters Patent should read as corrected below.
In the drawings, line 1, name of inventor, for "L. H. GILLON read J. H. GILLON Signed and sealed this, 17th day of July 1962.
(SEAL) Attest:
ERNEST w. SWIDER DAVID LADD Attesting Officer Commissioner of Patents
US31086A 1960-05-23 1960-05-23 Bottle stopper Expired - Lifetime US3025991A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US31086A US3025991A (en) 1960-05-23 1960-05-23 Bottle stopper

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31086A US3025991A (en) 1960-05-23 1960-05-23 Bottle stopper

Publications (1)

Publication Number Publication Date
US3025991A true US3025991A (en) 1962-03-20

Family

ID=21857573

Family Applications (1)

Application Number Title Priority Date Filing Date
US31086A Expired - Lifetime US3025991A (en) 1960-05-23 1960-05-23 Bottle stopper

Country Status (1)

Country Link
US (1) US3025991A (en)

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3810469A (en) * 1972-05-24 1974-05-14 Ampoules Inc Multiple compartment hypodermic devices
US3834571A (en) * 1972-11-20 1974-09-10 Warner Lambert Co Container closure for lyophilized products
US3881626A (en) * 1972-11-20 1975-05-06 Warner Lambert Co Container closure for lyophilized products
DE2902081A1 (en) * 1978-02-08 1979-08-09 Rumpler Jean Jacques STOPPER FOR DRUG CONTAINER
US5110004A (en) * 1989-03-23 1992-05-05 The Procter & Gamble Company Lid assembly
US6857755B1 (en) 2003-09-10 2005-02-22 Buztronics, Inc. Illuminated bottle cap with epoxy dome
US20050095284A1 (en) * 2003-10-31 2005-05-05 Alza Corporation Osmotic pump with self-retaining, fast-start membrane plug
US20050173366A1 (en) * 2004-02-06 2005-08-11 L'oreal Closure cap and a receptacle fitted with such a cap
US20060134354A1 (en) * 2004-12-16 2006-06-22 Walters Jay M Calibration vial stopper with improved security features
WO2007020240A1 (en) * 2005-08-13 2007-02-22 Boehringer Ingelheim International Gmbh Twin-chamber lyophilization receptacle, method for filling the same, and use thereof
US20070060876A1 (en) * 2005-08-13 2007-03-15 Stefan Bassarab Dual chamber container without by-pass
US20070060875A1 (en) * 2005-08-13 2007-03-15 Stefan Bassarab Dual chamber container without by-pass in the cylindrical body
US20070129673A1 (en) * 2005-08-13 2007-06-07 Stefan Bassarab Dual chamber container and process for its filling up
US20090001042A1 (en) * 2007-06-26 2009-01-01 Robert Sever Container-closure system for use in lyophilization applications
US20100206836A1 (en) * 2007-10-18 2010-08-19 Tsuyoshi Koshidaka Vial rubber-stopper
WO2012016301A1 (en) * 2010-08-06 2012-02-09 Hospira Australia Pty Ltd Vial preparation method and system
EP2517791A1 (en) * 2011-04-18 2012-10-31 Vibod GmbH Sample tube with improved lid
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US9682127B2 (en) 2005-02-03 2017-06-20 Intarcia Therapeutics, Inc. Osmotic delivery device comprising an insulinotropic peptide and uses thereof
US9724293B2 (en) 2003-11-17 2017-08-08 Intarcia Therapeutics, Inc. Methods of manufacturing viscous liquid pharmaceutical formulations
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10124534B2 (en) * 2013-07-18 2018-11-13 Bayerische Motoren Werke Aktiengesellschaft Adhesive aid and method for adhering components
USD835783S1 (en) 2016-06-02 2018-12-11 Intarcia Therapeutics, Inc. Implant placement guide
USD835506S1 (en) * 2017-05-24 2018-12-11 Helen Of Troy Limited Bottle stopper
US10159714B2 (en) 2011-02-16 2018-12-25 Intarcia Therapeutics, Inc. Compositions, devices and methods of use thereof for the treatment of cancers
US10231923B2 (en) 2009-09-28 2019-03-19 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
US20190185228A1 (en) * 2017-12-20 2019-06-20 Tecan Trading Ag Closure element with vent opening
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
US10501517B2 (en) 2016-05-16 2019-12-10 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
US10527170B2 (en) 2006-08-09 2020-01-07 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies for use therein
USD878915S1 (en) * 2018-09-18 2020-03-24 Midnight Madness Distilling, Llc Stopper
US10835580B2 (en) 2017-01-03 2020-11-17 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug
US20210009320A1 (en) * 2019-07-09 2021-01-14 A. Raymond Et Cie Locking top for vessel having a neck
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
EP4166232A1 (en) * 2021-10-15 2023-04-19 Leica Mikrosysteme GmbH Storage container for storing a sample holder
USD1009627S1 (en) * 2021-12-17 2024-01-02 Stasis Preservation LLC Bottled beverage preservation cap

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB729903A (en) * 1953-12-11 1955-05-11 Renato Mantovani Closure for collapsible tubes
FR1200415A (en) * 1959-04-03 1959-12-21 Plastic container with axially sliding stopper in a seat between two corresponding extreme positions, one for the closure to be obtained, the other for the position for filling and pouring the contents
US2927709A (en) * 1959-07-07 1960-03-08 Faultless Rubber Co Bottle stopple
US2940627A (en) * 1958-02-25 1960-06-14 Lok Seal Inc Champagne bottle closure

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB729903A (en) * 1953-12-11 1955-05-11 Renato Mantovani Closure for collapsible tubes
US2940627A (en) * 1958-02-25 1960-06-14 Lok Seal Inc Champagne bottle closure
FR1200415A (en) * 1959-04-03 1959-12-21 Plastic container with axially sliding stopper in a seat between two corresponding extreme positions, one for the closure to be obtained, the other for the position for filling and pouring the contents
US2927709A (en) * 1959-07-07 1960-03-08 Faultless Rubber Co Bottle stopple

Cited By (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3810469A (en) * 1972-05-24 1974-05-14 Ampoules Inc Multiple compartment hypodermic devices
US3834571A (en) * 1972-11-20 1974-09-10 Warner Lambert Co Container closure for lyophilized products
US3881626A (en) * 1972-11-20 1975-05-06 Warner Lambert Co Container closure for lyophilized products
DE2902081A1 (en) * 1978-02-08 1979-08-09 Rumpler Jean Jacques STOPPER FOR DRUG CONTAINER
US5110004A (en) * 1989-03-23 1992-05-05 The Procter & Gamble Company Lid assembly
US6857755B1 (en) 2003-09-10 2005-02-22 Buztronics, Inc. Illuminated bottle cap with epoxy dome
US20050095284A1 (en) * 2003-10-31 2005-05-05 Alza Corporation Osmotic pump with self-retaining, fast-start membrane plug
US7407499B2 (en) * 2003-10-31 2008-08-05 Intarcia Therapeutics, Inc. Osmotic pump with self-retaining, fast-start membrane plug
US20080269726A1 (en) * 2003-10-31 2008-10-30 Intarcia Therapeutics, Inc. Osmotic pump with self-retaining, fast-start membrane plug
US9724293B2 (en) 2003-11-17 2017-08-08 Intarcia Therapeutics, Inc. Methods of manufacturing viscous liquid pharmaceutical formulations
US20050173366A1 (en) * 2004-02-06 2005-08-11 L'oreal Closure cap and a receptacle fitted with such a cap
US7717281B2 (en) * 2004-02-06 2010-05-18 L'oreal Closure cap with a sealing stud having increased deformability and a receptacle fitted with such a cap
US20060134354A1 (en) * 2004-12-16 2006-06-22 Walters Jay M Calibration vial stopper with improved security features
WO2006066056A2 (en) * 2004-12-16 2006-06-22 Dade Behring Inc. Calibration vial stopper with improved security features
WO2006066056A3 (en) * 2004-12-16 2006-10-19 Dade Behring Inc Calibration vial stopper with improved security features
US9682127B2 (en) 2005-02-03 2017-06-20 Intarcia Therapeutics, Inc. Osmotic delivery device comprising an insulinotropic peptide and uses thereof
US10363287B2 (en) 2005-02-03 2019-07-30 Intarcia Therapeutics, Inc. Method of manufacturing an osmotic delivery device
US9539200B2 (en) 2005-02-03 2017-01-10 Intarcia Therapeutics Inc. Two-piece, internal-channel osmotic delivery system flow modulator
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US9526763B2 (en) 2005-02-03 2016-12-27 Intarcia Therapeutics Inc. Solvent/polymer solutions as suspension vehicles
US20090182301A1 (en) * 2005-08-13 2009-07-16 Stefan Bassarab Dual chamber container without by-pass
US8002734B2 (en) * 2005-08-13 2011-08-23 Boehringer Ingelheim International Gmbh Dual chamber container and process for its filling up
US8096971B2 (en) 2005-08-13 2012-01-17 Boehringer Ingelheim International Gmbh Dual chamber container for lyophilization, process for the filling up and use thereof
US20070060875A1 (en) * 2005-08-13 2007-03-15 Stefan Bassarab Dual chamber container without by-pass in the cylindrical body
US20070129673A1 (en) * 2005-08-13 2007-06-07 Stefan Bassarab Dual chamber container and process for its filling up
WO2007020240A1 (en) * 2005-08-13 2007-02-22 Boehringer Ingelheim International Gmbh Twin-chamber lyophilization receptacle, method for filling the same, and use thereof
US20070060876A1 (en) * 2005-08-13 2007-03-15 Stefan Bassarab Dual chamber container without by-pass
US20070060877A1 (en) * 2005-08-13 2007-03-15 Stefan Bassarab Dual chamber container for lyophilization, process for the filling up and use thereof
US10527170B2 (en) 2006-08-09 2020-01-07 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies for use therein
US20090001042A1 (en) * 2007-06-26 2009-01-01 Robert Sever Container-closure system for use in lyophilization applications
US20100206836A1 (en) * 2007-10-18 2010-08-19 Tsuyoshi Koshidaka Vial rubber-stopper
US9572889B2 (en) 2008-02-13 2017-02-21 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US10441528B2 (en) 2008-02-13 2019-10-15 Intarcia Therapeutics, Inc. Devices, formulations, and methods for delivery of multiple beneficial agents
US10231923B2 (en) 2009-09-28 2019-03-19 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
US10869830B2 (en) 2009-09-28 2020-12-22 Intarcia Therapeutics, Inc. Rapid establishment and/or termination of substantial steady-state drug delivery
US10364053B2 (en) * 2010-08-06 2019-07-30 Hospira Australia Pty Ltd Vial preparation method and system
CN103770967A (en) * 2010-08-06 2014-05-07 护益仁澳大利亚私人有限公司 Vial preparation method and system
CN103770967B (en) * 2010-08-06 2017-08-15 护益仁澳大利亚私人有限公司 The preparation method and system of bottle
US20130205719A1 (en) * 2010-08-06 2013-08-15 Emma J. Wensley Vial preparation method and system
AU2011286179B2 (en) * 2010-08-06 2016-05-05 Hospira Australia Pty Ltd Vial preparation method and system
WO2012016301A1 (en) * 2010-08-06 2012-02-09 Hospira Australia Pty Ltd Vial preparation method and system
CN103209898A (en) * 2010-08-06 2013-07-17 护益仁澳大利亚私人有限公司 Vial preparation method and system
US10159714B2 (en) 2011-02-16 2018-12-25 Intarcia Therapeutics, Inc. Compositions, devices and methods of use thereof for the treatment of cancers
EP2517791A1 (en) * 2011-04-18 2012-10-31 Vibod GmbH Sample tube with improved lid
WO2013053620A1 (en) 2011-10-13 2013-04-18 Vibod Gmbh Sample tube with improved lid
JP2014534058A (en) * 2011-10-13 2014-12-18 フィボット ゲーエムベーハー Sample tube with improved lid
US10124534B2 (en) * 2013-07-18 2018-11-13 Bayerische Motoren Werke Aktiengesellschaft Adhesive aid and method for adhering components
US10583080B2 (en) 2014-09-30 2020-03-10 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
US10501517B2 (en) 2016-05-16 2019-12-10 Intarcia Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
US11214607B2 (en) 2016-05-16 2022-01-04 Intarcia Therapeutics Inc. Glucagon-receptor selective polypeptides and methods of use thereof
US11840559B2 (en) 2016-05-16 2023-12-12 I2O Therapeutics, Inc. Glucagon-receptor selective polypeptides and methods of use thereof
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
USD835783S1 (en) 2016-06-02 2018-12-11 Intarcia Therapeutics, Inc. Implant placement guide
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD912249S1 (en) 2016-06-02 2021-03-02 Intarcia Therapeutics, Inc. Implant removal tool
USD962433S1 (en) 2016-06-02 2022-08-30 Intarcia Therapeutics, Inc. Implant placement guide
US11654183B2 (en) 2017-01-03 2023-05-23 Intarcia Therapeutics, Inc. Methods comprising continuous administration of exenatide and co-administration of a drug
US10835580B2 (en) 2017-01-03 2020-11-17 Intarcia Therapeutics, Inc. Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug
USD835506S1 (en) * 2017-05-24 2018-12-11 Helen Of Troy Limited Bottle stopper
US20190185228A1 (en) * 2017-12-20 2019-06-20 Tecan Trading Ag Closure element with vent opening
USD933219S1 (en) 2018-07-13 2021-10-12 Intarcia Therapeutics, Inc. Implant removal tool and assembly
USD878915S1 (en) * 2018-09-18 2020-03-24 Midnight Madness Distilling, Llc Stopper
US20210009320A1 (en) * 2019-07-09 2021-01-14 A. Raymond Et Cie Locking top for vessel having a neck
US11738915B2 (en) * 2019-07-09 2023-08-29 A. Raymond Et Cie Locking top for vessel having a neck
EP4166232A1 (en) * 2021-10-15 2023-04-19 Leica Mikrosysteme GmbH Storage container for storing a sample holder
USD1009627S1 (en) * 2021-12-17 2024-01-02 Stasis Preservation LLC Bottled beverage preservation cap

Similar Documents

Publication Publication Date Title
US3025991A (en) Bottle stopper
US5060812A (en) Medication container stopper which can be punctured by nozzle of a hypodermic syringe
US2927709A (en) Bottle stopple
US2848130A (en) Pressure resistant closures
US4089432A (en) Vial and closure
US5224515A (en) Tube closure
US2906423A (en) Closure puncturable by polyethylene needle
US4193402A (en) Bottle stopper and method of using said stopper
US4296786A (en) Transfer device for use in mixing a primary solution and a secondary or additive substance
US3674028A (en) Multi-mix
US3439823A (en) Container stopper comprising a hollow capsule
JP3549907B2 (en) Elastic plug
US4133462A (en) Container closure
US3842790A (en) Container closure
US2582721A (en) Bottle closure
US2731053A (en) Medical containers and their closures
US3013687A (en) Closure for packages of biological products
CA2924163C (en) Flow restrictor
US3017049A (en) Safety closure for containers
US3817418A (en) Threaded container seal
US2886198A (en) Bottle stopping device
US2324237A (en) Container
US2718974A (en) Expansion stopper
US4200100A (en) Additive transfer unit with piercing member having a penetratable protective tip
US3540612A (en) Bottle cap and bottle combination