US3007848A - Method of forming an edible medicinal wafer strip package - Google Patents
Method of forming an edible medicinal wafer strip package Download PDFInfo
- Publication number
- US3007848A US3007848A US720939A US72093958A US3007848A US 3007848 A US3007848 A US 3007848A US 720939 A US720939 A US 720939A US 72093958 A US72093958 A US 72093958A US 3007848 A US3007848 A US 3007848A
- Authority
- US
- United States
- Prior art keywords
- edible
- wafers
- medicinal
- lamina
- dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B9/00—Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
- B65B9/02—Enclosing successive articles, or quantities of material between opposed webs
- B65B9/023—Packaging fluent material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/078—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of wafers or cachets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B9/00—Enclosing successive articles, or quantities of material, e.g. liquids or semiliquids, in flat, folded, or tubular webs of flexible sheet material; Subdividing filled flexible tubes to form packages
- B65B9/02—Enclosing successive articles, or quantities of material between opposed webs
- B65B9/04—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material
- B65B9/042—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material for fluent material
Definitions
- This invention relates to a new dosage form of medicines which are intended to be taken orally and as a substitute for the other difiicult-to-swallow forms, such as pills, tablets, capsules, and the like.
- the invention further relates to methods for producing this dosage form in a plurality of alternate ways.
- the primary object of the invention is to provide a new form, which is easier to swallow than the present forms of medical dosages.
- Another object is to provide a thin wafer-like article in dosage form, which is pliant and may be easily swallowed.
- Another object is to provide a wafer form having a consistency which is immediately rendered slippery when the moisture of the mouth contacts it and thus produces a structure which is easy to swallow.
- a further object is to provide an. integral structure comprising the medical substance and a non-removable cover which is composed of an edible substance having the aforesaid characteristics and producing a slippery Wafer for the ease of swallowing.
- a still further objective is to produce a form of dosage such as the previous described form which has a protective cover that may be easily removed but which is an integral part of the whole.
- One of the objects of the invention is to provide a method for constantly extruding a thin flat ribbon upon a belt and passing that ribbon through a timed knife, which will segregate the ribbon into small fiat wafers.
- Still a further object of this invention is to provide a method for intermittently extruding flat wafers of medicinal substance in a dosage form in timed relationship with a fabricating operation which integrally associates a cover of edible film With the dosage to produce an edible wafer-like form.
- Another objective is to provide a method of creating the flat Wafer-like form by imprinting the medicinal dosage on an edible film of fabricating material and creating a complete closure of the dosage.
- a further objective of this invention is to use a method of imprinting the dosage on an edible film and then associating an outer protective film directly with this structure but associating the protective cover with a light-sealing adhesion, which will make this protective cover easily removable.
- a further object will be to provide an unsealed margin of the protective cover, Whose areas are readily grasped to facilitate the easy removal of the protective cover.
- FIGURE 1 is a perspective and FIG. 2 an enlarged sectional elevation of the simplest form of the invention which is an extruded edible substance, which might be of polyvinyl alcohol, carboxy methyl cellulose, or methylcellulose, or any other soluble edible substance, which can be blended with a medicinal dosage in a controlled proportion and extruded in a thin form.
- an extruded edible substance which might be of polyvinyl alcohol, carboxy methyl cellulose, or methylcellulose, or any other soluble edible substance, which can be blended with a medicinal dosage in a controlled proportion and extruded in a thin form.
- FIG. 3 is a perspective and FIG. 4 is an enlarged sectional elevation of a wafer similar to that of FIGS. 1 and 2, except that a covering of edible film is added.
- FIG. 5 is a perspective view and FIG. 6 is an enlarged sectional elevation of a wafer similar to that of FIGS. 3 and 4, except that an outer removable protective cover strip has been added.
- the cover strip is lightly sealed and preferably has extended edges, as shown, so that it can be easily removed from the thin wafer-like edible portron.
- FIG. 7 shows diagrammatically a constant extruder implanting a thin ribbon of extrudable gelatinous and edible substance containing a percentage of medicinal substances upon a continuous belt, that belt conveying, curing and passing the ribbon of medicinally impregnated extrusion onward to a knife mechanism which is operating in a timed relationship to produce medicinal wafers, as shown in FIGS. 1 and 2.
- FIG. 8 shows diagrammatically an intermittently timed dosage extruder extruding a flat series of wafers of known dimension and having a composite character of the extruduum plus a medicinal substance in whatever percentage the dosage requirement calls for.
- These wafers are deposited upon an edible film of material which is continuously moving between sealing dies that are enclosing the medicinal dosages between edible films. ing dies themselves, in this case sever the enclosing films and the separate wafers are a direct resultant of this fabricating operation.
- FIG. 9 shows diagrammatically another means of applying medicinal dosages to edible films in prescribed quantities.
- This includes a printing wheel, which passes underneath a dosage supply chamber and printing receptacles in the printing wheel are filled with dosage quantities of a substance.
- the doctor blades which are usual to this type of printing operation, remove the excess quantities of the dosage, other than that which is in the printing recesses, and these recesses then progress in their continuous passage over the infeeding edible film to imprint the dosage upon the web. These webs are then all formed together in one integral mass.
- the method of producing the thin wafers illustrated in FIGS. 1 and 2 may be carried out by the use of the apparatus shown in FIG. 7.
- This includes a continuous belt 10 mounted on drums 11 and 12 at least one of which is driven by an electric motor or other suitable means not shown.
- the drum 11 is heated by electric heater 13 which controls the temperature of the belt 10.
- a continuous ribbon of gelatinous material containing the proper proportion of medicinal substance is continuously discharged onto the top of the belt from an extruder 14.
- the ribbon is conditioned as it travels along the belt 10 and continues downwardly from the drum 12 in the form of a ribbon 15 which is cut into a series of medical wafers 16 by the usual form of reciprocating knife indicated at 17.
- a modified apparatus is diagrammatically illustrated in FIG. 8 and is adapted to produce the medicinal wafers having edible film outer coverings as shown in FIGS. 3 and 4.
- edible film 25 from a roll 18- passes over drums 19 and 20 and over sta iffy table or support 21, and intermittent extruder 22 supplies timed dosages onto the edible film 25.
- the fabricating drum has a series of pockets 29 which are coordinated in timed relation to the dosages extruded, and the edible film 27 passes between drum 20 and the fabricating drum 26 in such manner that the extruded dosages are formed between the drums, with edible film on each side.
- Heat may be applied to the drum 20, and the edible films are slightly wider than the dosages and extend beyond the pockets 29 of the fabricating drum.
- the series of medicinal units are thus interconnected and may be wound in a tight coil or they may be segregated in the individual wafers by a cutting knife, not shown.
- the seal- 3 and 6, may be carried out matically shown in FIG. 9, in which drums 30 and 3 1 correspond to drums 19 and 2-0, and table 32. corresponds to table 21.
- a protective removable film 35 i s fed from roll 36, and such removable film 35 and edible film 37 fromvroll 38 are fed together over drum- 30 andtable 32. As shown, the protective film 35 is next to the table and the edible film 37 is above it.
- a printing wheel 40 is mounted above the film 37, and a dosage of mixed gelatinous material and medicinal substances is fed onto the printing wheel in quantities controlled by the doctor blades 41 of the hopper 42, the arrangementbeing such that the printing wheel 40', which has a series of circumferential serrations 43, prints or deposits by a printing operation a series of spaced dosages onto the film 37.
- the dosages proceed between the drum 3 1 and a fabricating Wheel 44, which corresponds to the fabricating drum 26.
- a protective film 4-5 from a roll 46 is fed immediately over the fabricating drum 44, and above it is fed edible film 47 from roll 48.
- edible film 47 from roll 48.
- the protective films are made wider than the edible films on at least one side, and moreover they are lightly sealed, whereas the edible films are tightly sealed together by the cooperation of the cylindrical edges of the fabricating drum 4-4 and the drum 3 1, which together act as together by heat or pressure or both.
- the outer protective films are lightly sealed to the inner films but are readily removable therefrom.
- the method of forming a series of thin medicinal wafers in a single continuous operation comprises continuously passing a laminated strip composed of an outer protective lamina and an inner edible lamina over a printing table, depositing the medicinal wafers thereon from a printing wheel mounted to cooperate with the printing table, supplying a dosage substance of suitable consistency to the printing wheel, adding an outer laminated strip composed of an inner edible lamina and an outer protective lamina over the Wafers and passing the strips with the interposed wafers through rotary dies'to fuse the inner edible laminae together and to seal the protective laminae over the edible laminae and severing the strips to form a plurality of protected medicinal wafers.
- the method of forming a series of thin medicinal wafers in a single continuous operation comprises continuously passing a laminated strip composed of an outer protective lamina and an inner edible lamina over a table, depositing a series of medicinal wafers thereon by extrusion, supplying a dosage substance of suitable consistency for extrusion, adding an outer laminated strip composed of an inner edible lamina'and an outer protective lamina over the wafers and passing the strips with the interposed wafers through rotary dies to fuse the inner edible strips together and to seal the protective coating laminae over the edible strips and severing the strips to form protected wafers.
Description
NOV. 7, 1961 STROOP 3,007,848
METHOD OF FORMING AN EDIBLE MEDICINAL WAFER STRIP PACKAGE Filed March 12, 1958 2 Sheets-Sheet 1 Tia. E.
HIM
MfD/CAZ WAFER INVENTOR. JOHN /7. Smoop BY$%. 6 m
Nov. 7, 1961 J. H. STROOP 3,007,848
METHOD OF FORMING AN EDIBLE MEDICINAL WAFER STRIP PACKAGE Filed March 12, 1958 2 Sheets-Sheet 2 0207507705 E EEMOI/ABZE 005/205 50/515 5/40 505502005 5/4/10 46 I P/P/A/T/A/G 4/ WHEEL 45 INVENTOR. Jay/v h. Yr/e005 50/545 5/4/14 BY 5504004515 5/0 Q M011 atent Ofi 3,007,848 Patented Nov. 7, 1961 3,007,848 METHOD OF FORMING AN EDIBLE MEDICINAL WAFER STRIP PACKAGE John H. Stroop, New York, N.Y., assignor to Vol-Pak, Inc, New York, N.Y., a corporation of New York Filed Mar. 12, 1958, Ser. No. 720,939 2 Claims. Cl. 167-83) This invention relates to a new dosage form of medicines which are intended to be taken orally and as a substitute for the other difiicult-to-swallow forms, such as pills, tablets, capsules, and the like. The invention further relates to methods for producing this dosage form in a plurality of alternate ways.
The primary object of the invention is to provide a new form, which is easier to swallow than the present forms of medical dosages.
Another object is to provide a thin wafer-like article in dosage form, which is pliant and may be easily swallowed.
Another object is to provide a wafer form having a consistency which is immediately rendered slippery when the moisture of the mouth contacts it and thus produces a structure which is easy to swallow.
A further object is to provide an. integral structure comprising the medical substance and a non-removable cover which is composed of an edible substance having the aforesaid characteristics and producing a slippery Wafer for the ease of swallowing.
A still further objective is to produce a form of dosage such as the previous described form which has a protective cover that may be easily removed but which is an integral part of the whole.
One of the objects of the invention is to provide a method for constantly extruding a thin flat ribbon upon a belt and passing that ribbon through a timed knife, which will segregate the ribbon into small fiat wafers.
Still a further object of this invention is to provide a method for intermittently extruding flat wafers of medicinal substance in a dosage form in timed relationship with a fabricating operation which integrally associates a cover of edible film With the dosage to produce an edible wafer-like form.
Another objective is to provide a method of creating the flat Wafer-like form by imprinting the medicinal dosage on an edible film of fabricating material and creating a complete closure of the dosage.
A further objective of this invention is to use a method of imprinting the dosage on an edible film and then associating an outer protective film directly with this structure but associating the protective cover with a light-sealing adhesion, which will make this protective cover easily removable.
A further object will be to provide an unsealed margin of the protective cover, Whose areas are readily grasped to facilitate the easy removal of the protective cover.
To clarify these objectives of the invention and illustrate the best embodiment of the invention now known, the accompanying drawings are referred to as follows:
FIGURE 1 is a perspective and FIG. 2 an enlarged sectional elevation of the simplest form of the invention which is an extruded edible substance, which might be of polyvinyl alcohol, carboxy methyl cellulose, or methylcellulose, or any other soluble edible substance, which can be blended with a medicinal dosage in a controlled proportion and extruded in a thin form.
FIG. 3 is a perspective and FIG. 4 is an enlarged sectional elevation of a wafer similar to that of FIGS. 1 and 2, except that a covering of edible film is added.
FIG. 5 is a perspective view and FIG. 6 is an enlarged sectional elevation of a wafer similar to that of FIGS. 3 and 4, except that an outer removable protective cover strip has been added. The cover strip is lightly sealed and preferably has extended edges, as shown, so that it can be easily removed from the thin wafer-like edible portron.
FIG. 7 shows diagrammatically a constant extruder implanting a thin ribbon of extrudable gelatinous and edible substance containing a percentage of medicinal substances upon a continuous belt, that belt conveying, curing and passing the ribbon of medicinally impregnated extrusion onward to a knife mechanism which is operating in a timed relationship to produce medicinal wafers, as shown in FIGS. 1 and 2.
FIG. 8 shows diagrammatically an intermittently timed dosage extruder extruding a flat series of wafers of known dimension and having a composite character of the extruduum plus a medicinal substance in whatever percentage the dosage requirement calls for. These wafers are deposited upon an edible film of material which is continuously moving between sealing dies that are enclosing the medicinal dosages between edible films. ing dies themselves, in this case sever the enclosing films and the separate wafers are a direct resultant of this fabricating operation.
FIG. 9 shows diagrammatically another means of applying medicinal dosages to edible films in prescribed quantities. This includes a printing wheel, which passes underneath a dosage supply chamber and printing receptacles in the printing wheel are filled with dosage quantities of a substance. The doctor blades, which are usual to this type of printing operation, remove the excess quantities of the dosage, other than that which is in the printing recesses, and these recesses then progress in their continuous passage over the infeeding edible film to imprint the dosage upon the web. These webs are then all formed together in one integral mass.
The method of producing the thin wafers illustrated in FIGS. 1 and 2 may be carried out by the use of the apparatus shown in FIG. 7. This includes a continuous belt 10 mounted on drums 11 and 12 at least one of which is driven by an electric motor or other suitable means not shown. The drum 11 is heated by electric heater 13 which controls the temperature of the belt 10. A continuous ribbon of gelatinous material containing the proper proportion of medicinal substance is continuously discharged onto the top of the belt from an extruder 14. The ribbon is conditioned as it travels along the belt 10 and continues downwardly from the drum 12 in the form of a ribbon 15 which is cut into a series of medical wafers 16 by the usual form of reciprocating knife indicated at 17.
A modified apparatus is diagrammatically illustrated in FIG. 8 and is adapted to produce the medicinal wafers having edible film outer coverings as shown in FIGS. 3 and 4. In FIG. 8 edible film 25 from a roll 18- passes over drums 19 and 20 and over sta ionary table or support 21, and intermittent extruder 22 supplies timed dosages onto the edible film 25.
Cooperating with the drum 20 is a fabricating drum 26, and a second edible strip 27 is fed from roll 28 located above the fabricating drum. The fabricating drum has a series of pockets 29 which are coordinated in timed relation to the dosages extruded, and the edible film 27 passes between drum 20 and the fabricating drum 26 in such manner that the extruded dosages are formed between the drums, with edible film on each side. Heat may be applied to the drum 20, and the edible films are slightly wider than the dosages and extend beyond the pockets 29 of the fabricating drum. Thus the edible strips are sealed at their edges, as shown in FIG. 4. The series of medicinal units are thus interconnected and may be wound in a tight coil or they may be segregated in the individual wafers by a cutting knife, not shown.
A desirable method for producing the medicinal wafer with an outer protective covering, as shown in FIGS. 5
The seal- 3 and 6, may be carried out matically shown in FIG. 9, in which drums 30 and 3 1 correspond to drums 19 and 2-0, and table 32. corresponds to table 21. A protective removable film 35 i s fed from roll 36, and such removable film 35 and edible film 37 fromvroll 38 are fed together over drum- 30 andtable 32. As shown, the protective film 35 is next to the table and the edible film 37 is above it.
A printing wheel 40 is mounted above the film 37, and a dosage of mixed gelatinous material and medicinal substances is fed onto the printing wheel in quantities controlled by the doctor blades 41 of the hopper 42, the arrangementbeing such that the printing wheel 40', which has a series of circumferential serrations 43, prints or deposits by a printing operation a series of spaced dosages onto the film 37.
The dosages proceed between the drum 3 1 and a fabricating Wheel 44, which corresponds to the fabricating drum 26.
In this structure a protective film 4-5 from a roll 46 is fed immediately over the fabricating drum 44, and above it is fed edible film 47 from roll 48. Thus there passes between the drum 3 1 and the fabricating drum 4 4 a laminated strip which includes two outer protective films and two inner edible films between which the printed dosages are subjected to the action of the fabricating drum 44.
by the apparatus diagram- There is thus produced a strip composed of a series of medicinal units which are illustrated in FIGS. 5 and 6, and these may be cut into individual units by a knife, not shown.
In order to enable the protective films to be readily removed by the patient just before the medicinal unit is consumed, the protective films are made wider than the edible films on at least one side, and moreover they are lightly sealed, whereas the edible films are tightly sealed together by the cooperation of the cylindrical edges of the fabricating drum 4-4 and the drum 3 1, which together act as together by heat or pressure or both. At the same time the outer protective films are lightly sealed to the inner films but are readily removable therefrom.
This application is a continuation-in-part of my application Serial No. 603,777, filed August 13, 1956, now US. Patent No. 2,836,291, for Edible Strip Package and dies to seal the edges of the edible film 4 1 Method of Making Same; which in turn is a continuationin-part of original application Serial No. 386,370, filed October 15, 1953 now abandoned.
The foregoing description is intended to be illustrative only and variations may be made by those skilled in the art without departing from the spirit of the invention. Hence I desire that only such limitations be imposed 'as are set forth in the appended claims.
What I claim:
1. The method of forming a series of thin medicinal wafers in a single continuous operation that comprises continuously passing a laminated strip composed of an outer protective lamina and an inner edible lamina over a printing table, depositing the medicinal wafers thereon from a printing wheel mounted to cooperate with the printing table, supplying a dosage substance of suitable consistency to the printing wheel, adding an outer laminated strip composed of an inner edible lamina and an outer protective lamina over the Wafers and passing the strips with the interposed wafers through rotary dies'to fuse the inner edible laminae together and to seal the protective laminae over the edible laminae and severing the strips to form a plurality of protected medicinal wafers.
2. The method of forming a series of thin medicinal wafers in a single continuous operation that comprises continuously passing a laminated strip composed of an outer protective lamina and an inner edible lamina over a table, depositing a series of medicinal wafers thereon by extrusion, supplying a dosage substance of suitable consistency for extrusion, adding an outer laminated strip composed of an inner edible lamina'and an outer protective lamina over the wafers and passing the strips with the interposed wafers through rotary dies to fuse the inner edible strips together and to seal the protective coating laminae over the edible strips and severing the strips to form protected wafers.
References Cited in the file of this patent UNITED STATES PATENTS 222,135 Hoffman Dec. 2, 1879 2,130,887 Kremmling Sept. 20, 1938 2,774,313 Lombi Dec. 18, 1956 2,836,291 Stroop May 27, 1958
Claims (1)
1. THE METHOD OF FORMING A SERIES OF THIN MEDICINAL WAFERS IN A SINGLE CONTINUOUS OPERATION THAT COMPRISES CONTINUOUSLY PASSING A LAMINATED STRIP COMPOSED OF AN OUTER PROTECTIVE LAMINA AND AN INNER EDIBLE LAMINA OVER A PRINTING TABLE, DEPOSITING THE MEDICINAL WAFERS THEREON FROM A PRINTING WHEEL MOUNTED TO COOPERATE WITH THE PRINTING TABLE, SUPPLYING A DOSAGE SUBSTANCE OF SUITABLE CONSISTENCY TO THE PRINTING WHEEL, ADDING AN OUTER LAMINATED STRIP COMPOSED OF AN INNER EDIBLE LAMINA AND AN OUTER PROTECTIVE LAMINA OVER THE WAFERS AND PASSING THE STRIPS WITH THE INTERPOSED WAFERS THROUGH ROTARY DIES TO FUSE THE INNER EDIBLE LAMINAE TOGETHER AND TO SEAL THE PROTECTIVE LAMINAE OVER THE EDIBLE LAMINAE AND SEVERING THE STRIPS TO FORM A PLURALITY OF PROTECTED MEDICINAL WAFERS.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US720939A US3007848A (en) | 1958-03-12 | 1958-03-12 | Method of forming an edible medicinal wafer strip package |
BE576580A BE576580A (en) | 1958-03-12 | 1959-03-11 | Edible packaging. |
FR789150A FR1218817A (en) | 1958-03-12 | 1959-03-12 | Pharmaceutical stamp |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US720939A US3007848A (en) | 1958-03-12 | 1958-03-12 | Method of forming an edible medicinal wafer strip package |
Publications (1)
Publication Number | Publication Date |
---|---|
US3007848A true US3007848A (en) | 1961-11-07 |
Family
ID=24895862
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US720939A Expired - Lifetime US3007848A (en) | 1958-03-12 | 1958-03-12 | Method of forming an edible medicinal wafer strip package |
Country Status (3)
Country | Link |
---|---|
US (1) | US3007848A (en) |
BE (1) | BE576580A (en) |
FR (1) | FR1218817A (en) |
Cited By (54)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3409961A (en) * | 1963-12-16 | 1968-11-12 | Jerome H. Lemelson | Apparatus for making composite sheet materials |
US3596428A (en) * | 1968-10-07 | 1971-08-03 | American Maize Prod Co | Packaging process and apparatus |
US4029757A (en) * | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4029758A (en) * | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Preparation of pharmaceutical unit dosage forms |
US4031200A (en) * | 1975-12-15 | 1977-06-21 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4072551A (en) * | 1975-12-15 | 1978-02-07 | Hoffman-La Roche Inc. | Novel dosage form |
US4083741A (en) * | 1975-12-15 | 1978-04-11 | Hoffmann-La Roche, Inc. | Novel dosage form |
US4126503A (en) * | 1975-12-15 | 1978-11-21 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical dosage forms |
US4128444A (en) * | 1975-12-15 | 1978-12-05 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4128445A (en) * | 1975-12-15 | 1978-12-05 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4165998A (en) * | 1975-12-15 | 1979-08-28 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical dosage forms |
US4197289A (en) * | 1975-12-15 | 1980-04-08 | Hoffmann-La Roche Inc. | Novel dosage forms |
US4307555A (en) * | 1975-12-15 | 1981-12-29 | Hoffmann-La Roche Inc. | System for producing dosage forms |
US4322449A (en) * | 1978-11-15 | 1982-03-30 | Boehringer Ingelheim Gmbh | Pharmaceuticals having dotted active ingredients and a method and apparatus for the preparation thereof |
US4332789A (en) * | 1975-12-15 | 1982-06-01 | Hoffmann-La Roche Inc. | Pharmaceutical unit dosage forms |
US4349531A (en) * | 1975-12-15 | 1982-09-14 | Hoffmann-La Roche Inc. | Novel dosage form |
EP0202391A1 (en) * | 1985-05-23 | 1986-11-26 | Becton Dickinson and Company | Flexible packaging apparatus and method |
EP0244084A2 (en) * | 1986-04-01 | 1987-11-04 | Maufant Engineering Design Limited | Packaging |
DK152172B (en) * | 1975-12-15 | 1988-02-08 | Hoffmann La Roche | PROCEDURE FOR PREPARING A SOLID PHARMACEUTICAL UNIT DOSAGE FORM |
US4881359A (en) * | 1987-10-30 | 1989-11-21 | W. R. Grace & Co. | Method for making a vacuum skin package |
US5265401A (en) * | 1989-11-14 | 1993-11-30 | Thermarite Pty. Ltd. | Apparatus for manufacturing flexible containers |
DE19800682A1 (en) * | 1998-01-10 | 1999-07-15 | Lohmann Therapie Syst Lts | Primary packaging unit for film or wafer-like dosage forms |
WO2001062621A1 (en) | 2000-02-23 | 2001-08-30 | Lts Lohmann Therapie-Systeme Ag | Packaging for laminar objects with improved opening properties |
US6449925B1 (en) * | 1996-11-29 | 2002-09-17 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Method for preparing inclusion packaged product |
US20040258896A1 (en) * | 2001-10-12 | 2004-12-23 | Monosolrx Llc. | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US20080044454A1 (en) * | 2002-04-11 | 2008-02-21 | Monosolrx Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US20080131679A1 (en) * | 2006-12-01 | 2008-06-05 | Siltronic Ag | Silicon Wafer And Method For Manufacturing The Same |
US20080226695A1 (en) * | 2001-10-12 | 2008-09-18 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US20080292683A1 (en) * | 2007-05-24 | 2008-11-27 | Monosolrx, Llc. | Film shreds and delivery system incorporating same |
US20090104270A1 (en) * | 2007-10-19 | 2009-04-23 | Monosol Rx, Llc. | Film delivery system for tetrahydrolipstatin |
US20100040727A1 (en) * | 2008-08-18 | 2010-02-18 | Monosol Rx, Llc | Method for Improving Uniformity of Content in Edible Film Manufacturing |
US20100092545A1 (en) * | 2001-10-12 | 2010-04-15 | Monosol Rx, Llc | Polyethylene-oxide based films and drug delivery systems made therefrom |
US20100150987A1 (en) * | 2008-12-15 | 2010-06-17 | Monosol Rx, Llc | Method for Manufacturing Edible Film |
US20100221309A1 (en) * | 2001-10-12 | 2010-09-02 | Monosol Rx, Llc | Film compositions for delivery of actives |
US20100297232A1 (en) * | 2009-05-19 | 2010-11-25 | Monosol Rx, Llc | Ondansetron film compositions |
US20110160264A1 (en) * | 2009-12-28 | 2011-06-30 | Monosol Rx, Llc | Orally administrable film dosage forms containing ondansetron |
US7972618B2 (en) | 2006-09-20 | 2011-07-05 | Monosol Rx, Llc | Edible water-soluble film containing a foam reducing flavoring agent |
US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US8974826B2 (en) | 2010-06-10 | 2015-03-10 | Monosol Rx, Llc | Nanoparticle film delivery systems |
US9108340B2 (en) | 2001-10-12 | 2015-08-18 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US9205089B2 (en) | 2011-04-29 | 2015-12-08 | Massachusetts Institute Of Technology | Layer processing for pharmaceuticals |
BE1021600B1 (en) * | 2013-10-31 | 2015-12-17 | Astra Sweets N.V. | METHOD FOR MANUFACTURING A SUGAR WORK |
US10034833B2 (en) | 2009-08-07 | 2018-07-31 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US10213960B2 (en) | 2014-05-20 | 2019-02-26 | Massachusetts Institute Of Technology | Plasticity induced bonding |
US10272607B2 (en) | 2010-10-22 | 2019-04-30 | Aquestive Therapeutics, Inc. | Manufacturing of small film strips |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US11077068B2 (en) | 2001-10-12 | 2021-08-03 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US11191737B2 (en) | 2016-05-05 | 2021-12-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
CN115043017A (en) * | 2021-12-29 | 2022-09-13 | 北京福乐云数据科技有限公司 | Edible film packaging system |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2447392A (en) * | 1991-08-01 | 1993-03-02 | Packaging Concepts And Technologies International, Incorporated | Machine and method for heat seal lamination of textile fabric |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US222135A (en) * | 1879-12-02 | Improvement in machines for making yeast-cakes | ||
US2130887A (en) * | 1934-10-08 | 1938-09-20 | Kremmling Otto | Dough molding machine |
US2774313A (en) * | 1955-11-14 | 1956-12-18 | Ezio L Lombi | Ravioli machine |
US2836291A (en) * | 1956-08-13 | 1958-05-27 | Pad Y Wax Company Inc | Edible strip package and method of making same |
-
1958
- 1958-03-12 US US720939A patent/US3007848A/en not_active Expired - Lifetime
-
1959
- 1959-03-11 BE BE576580A patent/BE576580A/en unknown
- 1959-03-12 FR FR789150A patent/FR1218817A/en not_active Expired
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US222135A (en) * | 1879-12-02 | Improvement in machines for making yeast-cakes | ||
US2130887A (en) * | 1934-10-08 | 1938-09-20 | Kremmling Otto | Dough molding machine |
US2774313A (en) * | 1955-11-14 | 1956-12-18 | Ezio L Lombi | Ravioli machine |
US2836291A (en) * | 1956-08-13 | 1958-05-27 | Pad Y Wax Company Inc | Edible strip package and method of making same |
Cited By (90)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3409961A (en) * | 1963-12-16 | 1968-11-12 | Jerome H. Lemelson | Apparatus for making composite sheet materials |
US3596428A (en) * | 1968-10-07 | 1971-08-03 | American Maize Prod Co | Packaging process and apparatus |
US4083741A (en) * | 1975-12-15 | 1978-04-11 | Hoffmann-La Roche, Inc. | Novel dosage form |
US4128444A (en) * | 1975-12-15 | 1978-12-05 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4031200A (en) * | 1975-12-15 | 1977-06-21 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4069086A (en) * | 1975-12-15 | 1978-01-17 | Hoffmann-La Roche Inc. | Novel dosage form |
US4069084A (en) * | 1975-12-15 | 1978-01-17 | Hoffmann-La Roche Inc. | Novel dosage form |
US4072551A (en) * | 1975-12-15 | 1978-02-07 | Hoffman-La Roche Inc. | Novel dosage form |
DK152172B (en) * | 1975-12-15 | 1988-02-08 | Hoffmann La Roche | PROCEDURE FOR PREPARING A SOLID PHARMACEUTICAL UNIT DOSAGE FORM |
US4126503A (en) * | 1975-12-15 | 1978-11-21 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical dosage forms |
US4126502A (en) * | 1975-12-15 | 1978-11-21 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical dosage forms |
US4029758A (en) * | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Preparation of pharmaceutical unit dosage forms |
US4128445A (en) * | 1975-12-15 | 1978-12-05 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4165998A (en) * | 1975-12-15 | 1979-08-28 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical dosage forms |
US4197289A (en) * | 1975-12-15 | 1980-04-08 | Hoffmann-La Roche Inc. | Novel dosage forms |
US4307555A (en) * | 1975-12-15 | 1981-12-29 | Hoffmann-La Roche Inc. | System for producing dosage forms |
US4029757A (en) * | 1975-12-15 | 1977-06-14 | Hoffmann-La Roche Inc. | Manufacture of pharmaceutical unit dosage forms |
US4332789A (en) * | 1975-12-15 | 1982-06-01 | Hoffmann-La Roche Inc. | Pharmaceutical unit dosage forms |
US4349531A (en) * | 1975-12-15 | 1982-09-14 | Hoffmann-La Roche Inc. | Novel dosage form |
US4322449A (en) * | 1978-11-15 | 1982-03-30 | Boehringer Ingelheim Gmbh | Pharmaceuticals having dotted active ingredients and a method and apparatus for the preparation thereof |
USRE31764E (en) * | 1978-11-15 | 1984-12-11 | Boehringer Ingelheim Gmbh | Pharmaceuticals having dotted active ingredients and a method and apparatus for the preparation thereof |
EP0202391A1 (en) * | 1985-05-23 | 1986-11-26 | Becton Dickinson and Company | Flexible packaging apparatus and method |
EP0244084A2 (en) * | 1986-04-01 | 1987-11-04 | Maufant Engineering Design Limited | Packaging |
EP0244084A3 (en) * | 1986-04-01 | 1988-09-14 | Maufant Engineering Design Limited | Packaging |
US4881359A (en) * | 1987-10-30 | 1989-11-21 | W. R. Grace & Co. | Method for making a vacuum skin package |
US5649409A (en) * | 1989-11-14 | 1997-07-22 | Thermarite Pty. Ltd. | Apparatus for manufacturing flexible containers |
US5265401A (en) * | 1989-11-14 | 1993-11-30 | Thermarite Pty. Ltd. | Apparatus for manufacturing flexible containers |
US6449925B1 (en) * | 1996-11-29 | 2002-09-17 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Method for preparing inclusion packaged product |
DE19800682A1 (en) * | 1998-01-10 | 1999-07-15 | Lohmann Therapie Syst Lts | Primary packaging unit for film or wafer-like dosage forms |
WO1999035051A1 (en) | 1998-01-10 | 1999-07-15 | Lts Lohmann Therapie-Systeme Ag | Primary packaging unit for film-like or oblate-like administered shapes |
AU736498B2 (en) * | 1998-01-10 | 2001-07-26 | Lts Lohmann Therapie-Systeme Ag | Primary packaging unit for film-like or wafer-like administration forms |
US6655112B1 (en) | 1998-01-10 | 2003-12-02 | Lts Lohmann Therapie-Systeme Ag | Primary packaging unit for film-like or oblate-like administered shapes |
DE19800682B4 (en) * | 1998-01-10 | 2004-07-08 | Lts Lohmann Therapie-Systeme Ag | Process for producing a primary packaging for film or wafer-shaped administration forms |
WO2001062621A1 (en) | 2000-02-23 | 2001-08-30 | Lts Lohmann Therapie-Systeme Ag | Packaging for laminar objects with improved opening properties |
US20100092545A1 (en) * | 2001-10-12 | 2010-04-15 | Monosol Rx, Llc | Polyethylene-oxide based films and drug delivery systems made therefrom |
US8685437B2 (en) | 2001-10-12 | 2014-04-01 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US7357891B2 (en) * | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US20080226695A1 (en) * | 2001-10-12 | 2008-09-18 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US20080260805A1 (en) * | 2001-10-12 | 2008-10-23 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US20080268027A1 (en) * | 2001-10-12 | 2008-10-30 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US11077068B2 (en) | 2001-10-12 | 2021-08-03 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US10888499B2 (en) | 2001-10-12 | 2021-01-12 | Aquestive Therapeutics, Inc. | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US20090182062A1 (en) * | 2001-10-12 | 2009-07-16 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US20040258896A1 (en) * | 2001-10-12 | 2004-12-23 | Monosolrx Llc. | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US9931305B2 (en) | 2001-10-12 | 2018-04-03 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US20100221309A1 (en) * | 2001-10-12 | 2010-09-02 | Monosol Rx, Llc | Film compositions for delivery of actives |
US7824588B2 (en) | 2001-10-12 | 2010-11-02 | Monosol Rx, Llc | Method of making self-supporting therapeutic active-containing film |
US9855221B2 (en) | 2001-10-12 | 2018-01-02 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US7897080B2 (en) | 2001-10-12 | 2011-03-01 | Monosol Rx, Llc | Polyethylene-oxide based films and drug delivery systems made therefrom |
US7910031B2 (en) * | 2001-10-12 | 2011-03-22 | Monosol Rx, Llc | Process for forming an ingestible thin film with non-self-aggregating uniform heterogeneity |
US9108340B2 (en) | 2001-10-12 | 2015-08-18 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US8906277B2 (en) | 2001-10-12 | 2014-12-09 | Monosol Rx, Llc | Process for manufacturing a resulting pharmaceutical film |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US8663687B2 (en) | 2001-10-12 | 2014-03-04 | Monosol Rx, Llc | Film compositions for delivery of actives |
US8652378B1 (en) | 2001-10-12 | 2014-02-18 | Monosol Rx Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US20080044454A1 (en) * | 2002-04-11 | 2008-02-21 | Monosolrx Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US10111810B2 (en) | 2002-04-11 | 2018-10-30 | Aquestive Therapeutics, Inc. | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US7972618B2 (en) | 2006-09-20 | 2011-07-05 | Monosol Rx, Llc | Edible water-soluble film containing a foam reducing flavoring agent |
US20080131679A1 (en) * | 2006-12-01 | 2008-06-05 | Siltronic Ag | Silicon Wafer And Method For Manufacturing The Same |
US8142885B2 (en) * | 2006-12-01 | 2012-03-27 | Siltronic Ag | Silicon wafer and method for manufacturing the same |
US20080292683A1 (en) * | 2007-05-24 | 2008-11-27 | Monosolrx, Llc. | Film shreds and delivery system incorporating same |
US8663696B2 (en) | 2007-10-19 | 2014-03-04 | Monosol Rx, Llc | Film delivery system for tetrahydrolipstatin |
US8298583B2 (en) | 2007-10-19 | 2012-10-30 | Monosol Rx, Llc | Film delivery system for tetrahydrolipstatin |
US20090104270A1 (en) * | 2007-10-19 | 2009-04-23 | Monosol Rx, Llc. | Film delivery system for tetrahydrolipstatin |
US20100040727A1 (en) * | 2008-08-18 | 2010-02-18 | Monosol Rx, Llc | Method for Improving Uniformity of Content in Edible Film Manufacturing |
US20100150987A1 (en) * | 2008-12-15 | 2010-06-17 | Monosol Rx, Llc | Method for Manufacturing Edible Film |
US8282954B2 (en) | 2008-12-15 | 2012-10-09 | Monosol Rx, Llc | Method for manufacturing edible film |
US20100297232A1 (en) * | 2009-05-19 | 2010-11-25 | Monosol Rx, Llc | Ondansetron film compositions |
US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
US10034833B2 (en) | 2009-08-07 | 2018-07-31 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US9687454B2 (en) | 2009-08-07 | 2017-06-27 | Indivior Uk Limited | Sublingual and buccal film compositions |
US11135216B2 (en) | 2009-08-07 | 2021-10-05 | Indivior Uk Limited | Sublingual and buccal film compositions |
US10821074B2 (en) | 2009-08-07 | 2020-11-03 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US20110160264A1 (en) * | 2009-12-28 | 2011-06-30 | Monosol Rx, Llc | Orally administrable film dosage forms containing ondansetron |
US8974826B2 (en) | 2010-06-10 | 2015-03-10 | Monosol Rx, Llc | Nanoparticle film delivery systems |
US10940626B2 (en) | 2010-10-22 | 2021-03-09 | Aquestive Therapeutics, Inc. | Manufacturing of small film strips |
US10272607B2 (en) | 2010-10-22 | 2019-04-30 | Aquestive Therapeutics, Inc. | Manufacturing of small film strips |
US9205089B2 (en) | 2011-04-29 | 2015-12-08 | Massachusetts Institute Of Technology | Layer processing for pharmaceuticals |
BE1021600B1 (en) * | 2013-10-31 | 2015-12-17 | Astra Sweets N.V. | METHOD FOR MANUFACTURING A SUGAR WORK |
US10703048B2 (en) | 2014-05-20 | 2020-07-07 | Massachusetts Institute Of Technology | Plasticity induced bonding |
US10213960B2 (en) | 2014-05-20 | 2019-02-26 | Massachusetts Institute Of Technology | Plasticity induced bonding |
US11191737B2 (en) | 2016-05-05 | 2021-12-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
CN115043017A (en) * | 2021-12-29 | 2022-09-13 | 北京福乐云数据科技有限公司 | Edible film packaging system |
CN115043017B (en) * | 2021-12-29 | 2023-08-15 | 北京福乐云科技有限公司 | Edible film packaging system |
Also Published As
Publication number | Publication date |
---|---|
BE576580A (en) | 1959-07-01 |
FR1218817A (en) | 1960-05-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US3007848A (en) | Method of forming an edible medicinal wafer strip package | |
US2836291A (en) | Edible strip package and method of making same | |
US4911304A (en) | Sandwich blister package for tablets and similar articles | |
US3542570A (en) | Process of manufacturing individually wrapped slices of extrudable products | |
US3713849A (en) | Meat package | |
US3339337A (en) | Envelope, apparatus and method for making and filling envelopes | |
US3069273A (en) | Method of packaging | |
US2545710A (en) | Package | |
US5074102A (en) | Flat track modified soft shell capsule filling machine | |
US2180966A (en) | Method and apparatus for packaging articles | |
US2472440A (en) | Machine for fabricating packages | |
US2486759A (en) | Packaging method and apparatus | |
US3659777A (en) | Reinforced package | |
US2663128A (en) | Method and machine for making capsules | |
US5472093A (en) | Tandem package and system for making same | |
US2663130A (en) | Apparatus for producing symmetrical generally ellipsoidal capsules | |
US1714265A (en) | Printing process | |
US2600222A (en) | Method of and apparatus for encapsulating substances | |
US3377773A (en) | Thermoplastic film packaging apparatus | |
US3258169A (en) | Package | |
US3942934A (en) | Mold assembly for use in packaging machine | |
WO2004045957A2 (en) | Systems and methods for forming blister packages with support members for pharmaceutical product packaging | |
US2603928A (en) | Packaging device | |
US3137580A (en) | Package and method and apparatus for forming same | |
US2775447A (en) | Capsule forming gelatin strip handling |