US2717601A - Syringe ampule - Google Patents

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US2717601A
US2717601A US216058A US21605851A US2717601A US 2717601 A US2717601 A US 2717601A US 216058 A US216058 A US 216058A US 21605851 A US21605851 A US 21605851A US 2717601 A US2717601 A US 2717601A
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stopper
ampule
bore
compartment
syringe
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US216058A
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Frank E Brown
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2448Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S215/00Bottles and jars
    • Y10S215/08Mixing
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S220/00Receptacles
    • Y10S220/916Container including axially opposed removable closures

Definitions

  • a further object is that of furnishing ampule structures capable of economical manufacture by quantity production methods and which ampules may be readily charged with diluent and medicament either manually or by machines.
  • Fig. 1 is a sectional side view of one form of ampule and showing the same in an initial and charged condition;
  • Fig. 2 is a view similar to Fig. 1 but illustrating the initial step in the manipulation of the ampule
  • Fig. 3 shows the position which the parts assume during the final stages of their manipulation
  • Fig. 4 is a transverse sectional view taken along the lines 4-4 and in the direction of the arrows asindicated in Fig. l;
  • Fig. 5 is a section of an alternative design
  • Fig. 6 is a sectional side view of a piston stopper which may be embraced in the assembly.
  • Fig. 7 is a similar view of a closure stopper which may also be included in that assembly.
  • the numeral 10 indicates a tubular ampule body preferably formed of glass although other materials might, in certain instances, be employed. As shown in Figs. 1 to 3 one end of the ampule is closed by a piston type stopper 11; the opposite end thereof being closed by a stopper 12. Between its ends the ampule body is formed with a pair of axially extending grooves 13.
  • a partition stopper 14 is mounted within the bore of the ampule and in advance of the grooves 13.
  • Compartment 15 receives a diluent and compartment 16 the medicament which will ordinarily be in the form of a dry powder, crystals, tablets, etc., etc. Compartment 15 should be of smaller capacity than compartment 16.
  • the central Zones of grooves 13 may be to the left of the center of the device as shown in Figs. 1 to 3.
  • Stoppers 11, 12 and 14 are conveniently formed of rubber and ridged. Obviously, where permissible, they might be formed of other material. Stopper 14 may be solid. Stopper 11 may be provided with an outwardly extending protuberance 17. This may be screw threaded 2,717,601 Patented Sept.'13, 1955 ice for engagement with a correspondingly threaded end of an actuating stem (not shown). If desired, the threads might be eliminated to provide for a slip fit between these parts. Otherwise as shown in Fig. 6 the stopper might be formed with a threaded recess 18 to engage the threaded end of an actuating stem. Stopper 12 may, as shown in Fig. 7, be formed with a head 19. In any event, it should be provided with a recess 20 or be otherwise constructed so as to be capable of being readily penetrated by the inner end of a needle.
  • ampule of this type may be used with syringes or barrels of various designs.
  • a holder mounting a double pointed needle may be employed as shown in United States patent to Steuer, 1,709,691, of April 16, 1929.
  • the ampule may be employed in connection with a barrel having a thrust or post portion as shown in United States patent to Hall, 1,848,711, of March 8, 1932.
  • an ampule embodying the present teachings will not be utilized with an assembly of the latter type. For this reason the operation of the unitwill be described in conjunction with the structure of a barrel similar to that of Steuer.
  • an actuator which may take one of numerous different forms is preferably employed.
  • the central area of body 10 might be somewhat compressed so that an oval or elliptical shaped passage is presented. This has been indicated by the numeral 23 in Fig. 5. As is apparent when stopper 14 enters this portion of the ampule incident to thrust being exerted upon stopper 11, that stopper 14 may distort somewhat as has been indicated in Fig. 5. However, it will not be deformed to an extent such that it completely fills the bore of the ampule. Therefore, passages 24 will exist between the inner face of that bore and the edge of stopper 14 through which the diluent may flow to the medicament compartment.
  • the length of the distorted or oval portion of the bore will be greater than the width of stopper 14. Therefore, liquid will transfer from compartment 15 as stopper 11 is moved to compartment 16. Only thereafter will stoppers 11 and 14 contact and shift as a unit in order to eject the solution from compartment 16.
  • the end portions of the oval configuration providing the passages 24 in effect furnish grooves or by-passes for the flow of liquid.
  • units constructed in accordance with the present teachings might also be employed free from association or combining with a syringe structure. In other words a physician or other user might-upon desiring to make an injectionsimply place a needle in a position Where it pierces stopper 12 as indicated in Fig. 3.
  • stopper 11 could conveniently be shifted somewhat to the right of the position shown in Fig. 2 so that too great a condition of vacuum would not arise in compartment 16.
  • both stoppers 11 and 14 might be shifted as a unit during the withdrawal action of the solution and as indicated in Fig. 3.
  • a by-pass provision is, in each instance, illustrated. This functions-in cooperation with the adjacent stopperto permit an intermixing of the diluent and medicament in the different compartments as that stopper is shifted.
  • the ampule is non-circular in cross section at a point intermediate its ends. In other words, in one form the continuity of the surface is interrupted by a groove or grooves while in the other form an elliptical or oval surface is presented.
  • An ampule including a tubular body, the bore of said body at a zone intermediate its ends being oval in cross section to provide relatively recessed portions, said portions furnishing a by-pass for liquid normally confined within the bore and to the rear of a resilient stopper as the latter is shifted axially of the bore in the zone of said portions.
  • ampule for removable disposal in a needlemounting syringe, said ampule including a tubular openended body circular in section adjacent at least one end, the bore of said body at a zone intermediate its ends being formed with a longitudinally extending groove in its face, a stopper adjacent said groove, the latter providing a by-pass for liquid normally confined within the bore and to the rear of said stopper as the latter is shifted axially of the bore into the zone of said by-pass, said bore adjacent one end of said body providing a seat, a piston type stopper cooperating therewith to provide a liquidtight seal, the opposite end of said body furnishing a second seat, a pierceable type stopper cooperating therewith, and edge means on said latter-named end for engagement with the internal end portion of a needlemounting syringe.
  • ampule for removable disposal in a needlemounting syringe, said ampule including a tubular openended body circular in section adjacent at least one end, the bore of said body at a zone intermediate its ends having at least a portion of its inner face spaced from the ampule axis a distance greater than at other points to provide a by-pass for liquid, a stopper within said bore adjacent said zone, said stopper confining liquid within the bore and to the rear of said stopper as the latter is shifted axially of the bore into the zone of said by-pass, said bore adjacent one end of said body'providing a seat, a pistontype stopper cooperating therewith to provide a liquidtight seal, the opposite end of said body furnishing a second seat, a pierceable type stopper cooperating therewith, and edge means on said latter-named end for engagement with the internal end portion of a needle-mounting syringe.
  • ampule for removable disposal in a needlemounting syringe, said ampule including a tubular openended body circular in section adjacent at least one end, the bore of said body at a zone intermediate its ends being formed with a longitudinally extending groove in its face to provide a by-pass for liquid normally confined within the bore, a stopper disposed adjacent said groove and providing a partition intermediate with ends of said body, a piston stopper adjacent one end of said bore and spaced from said first named stopper to furnish a compartment between the same, diluent within said compartment, said diluent flowing through said by-pass as said piston stopper is shifted axially of the bore to cause similar shifting of said first-named stopper in the zone of said groove, a pierceable type stopper adjacent the opposite end of said body and beyond said groove to provide a medicament compartment to receive the diluent flowing through said bypass, said bore furnishing seats for liquidtight seals for each of said stoppers at the normal positions of same, and edge means at the end

Description

Sept. 13, 1955 E, ROWN 2,717,601
SYRINGE AMPULE Original Filed Aug. 10, 1949 INVENTOR ATTORNEYS United States Patent SYRINGE AMPULE Frank E. Brown, Burbank, Calif., assignor to Frederick M. Turnbull, Los Angeles, Calif.
Original application August 10, 1949, Serial No. 109,430. Divided and this application March 16, 1951, Serial No. 216,058
4 Claims. (Cl. 128-272) This invention relates to a structurally and functionally improved ampule for use as part of a hypodermic syringe assembly; the present application being a division of the prior application for patent filed in my name under Serial Number 109,430 on August 10, 1949, now Patent No. 2,549,417 dated April 17, 1951.
It is an object of the invention to provide an improved ampule in which diluent and medicament may be maintained in sterile condition until it is desired to perform an injection; the creation of the solution at that time being achieved with minimum effort and expenditure of time.
A further object is that of furnishing ampule structures capable of economical manufacture by quantity production methods and which ampules may be readily charged with diluent and medicament either manually or by machines.
With these and other objects in mind, reference is had to the attached sheet of drawings illustrating practical embodiments of the invention and in which:
Fig. 1 is a sectional side view of one form of ampule and showing the same in an initial and charged condition;
Fig. 2 is a view similar to Fig. 1 but illustrating the initial step in the manipulation of the ampule;
Fig. 3 shows the position which the parts assume during the final stages of their manipulation;
Fig. 4 is a transverse sectional view taken along the lines 4-4 and in the direction of the arrows asindicated in Fig. l;
Fig. 5 is a section of an alternative design;
Fig. 6 is a sectional side view of a piston stopper which may be embraced in the assembly; and
Fig. 7 is a similar view of a closure stopper which may also be included in that assembly.
In these views the numeral 10 indicates a tubular ampule body preferably formed of glass although other materials might, in certain instances, be employed. As shown in Figs. 1 to 3 one end of the ampule is closed by a piston type stopper 11; the opposite end thereof being closed by a stopper 12. Between its ends the ampule body is formed with a pair of axially extending grooves 13.
These are clearly shown in Fig. 4; it being understood that a greater or lesser number of these rgrooves might be employed if desired. A partition stopper 14 is mounted within the bore of the ampule and in advance of the grooves 13.
In this manner compartments 15 and 16 are provided between stoppers 11 and 14 and 14 and 12. Compartment 15 receives a diluent and compartment 16 the medicament which will ordinarily be in the form of a dry powder, crystals, tablets, etc., etc. Compartment 15 should be of smaller capacity than compartment 16. In fact, the central Zones of grooves 13 may be to the left of the center of the device as shown in Figs. 1 to 3.
Stoppers 11, 12 and 14 are conveniently formed of rubber and ridged. Obviously, where permissible, they might be formed of other material. Stopper 14 may be solid. Stopper 11 may be provided with an outwardly extending protuberance 17. This may be screw threaded 2,717,601 Patented Sept.'13, 1955 ice for engagement with a correspondingly threaded end of an actuating stem (not shown). If desired, the threads might be eliminated to provide for a slip fit between these parts. Otherwise as shown in Fig. 6 the stopper might be formed with a threaded recess 18 to engage the threaded end of an actuating stem. Stopper 12 may, as shown in Fig. 7, be formed with a head 19. In any event, it should be provided with a recess 20 or be otherwise constructed so as to be capable of being readily penetrated by the inner end of a needle.
An ampule of this type may be used with syringes or barrels of various designs. For example, a holder mounting a double pointed needle may be employed as shown in United States patent to Steuer, 1,709,691, of April 16, 1929. Under certain circumstances the ampule may be employed in connection with a barrel having a thrust or post portion as shown in United States patent to Hall, 1,848,711, of March 8, 1932. However, it is contemplated that ordinarily an ampule embodying the present teachings will not be utilized with an assembly of the latter type. For this reason the operation of the unitwill be described in conjunction with the structure of a barrel similar to that of Steuer. In any event an actuator which may take one of numerous different forms is preferably employed.
Thus, a physician desiring to use the unit will apply an actuator to stopper 11. Thereupon he will exert a thrust upon that stopper. The ampule at the end containing stopper 12 may engage with the end portion of a needle-mounting syringe, as shown for instance, in the above-cited patents. Compartment 15 being filled with liquid diluent, which is substantially incompressible, it follows that such thrust will be imparted to stopper 14 which will therefore shift to the right as in Fig. 1 in substantial synchronism with the corresponding movements of stopper 11. The length of the by-pass grooves 13 being greater than the width of stopper 14, it follows that that stopper will shift for a distance such that the entrance and exit ends of these grooves extend beyond opposite stopper faces. When this occurs, stopper 11, under continued thrust, will project to displace the liquid through the grooves 13 into compartment 16. Either previously or at this time a hollow needle may have pierced stopper '12. With such piercing, air may vent.
The shifted position of the parts has been shown in Fig. 2. When stoppers 11 and 14 are moved into contact substantially all of the diluent will have been displaced to the medicament compartment. The ampule should now be agitated so that a proper solution is established within compartment 16. With continued thrust against stopper 11, stopper 14 will move into this compartment. Thereupon the needle may be cause to penetrate the epidermis. Continued thrust upon stopper 11 will cause this stopper as well as stopper 14 to move as a unit in the manner shown in Fig. 3 to expel the solution through the cannula which has pierced stopper 12. The first named stoppers will continue to move until the entire solution has been expelled from compartment 16. V
If it is desired to employ a structure other than the grooves, the central area of body 10 might be somewhat compressed so that an oval or elliptical shaped passage is presented. This has been indicated by the numeral 23 in Fig. 5. As is apparent when stopper 14 enters this portion of the ampule incident to thrust being exerted upon stopper 11, that stopper 14 may distort somewhat as has been indicated in Fig. 5. However, it will not be deformed to an extent such that it completely fills the bore of the ampule. Therefore, passages 24 will exist between the inner face of that bore and the edge of stopper 14 through which the diluent may flow to the medicament compartment.
Again in this form of structure the length of the distorted or oval portion of the bore will be greater than the width of stopper 14. Therefore, liquid will transfer from compartment 15 as stopper 11 is moved to compartment 16. Only thereafter will stoppers 11 and 14 contact and shift as a unit in order to eject the solution from compartment 16. In this form of structure, the end portions of the oval configuration providing the passages 24 in effect furnish grooves or by-passes for the flow of liquid. As will be apparent, units constructed in accordance with the present teachings might also be employed free from association or combining with a syringe structure. In other words a physician or other user might-upon desiring to make an injectionsimply place a needle in a position Where it pierces stopper 12 as indicated in Fig. 3. So positioned it would serve as a vent. The ampule or vial might now be disposed in a vertical position with the pierced stopper extending upwardly. By any suitable implement, stopper 11 could be projected to cause stopper 14 to be shifted in the manner aforedescribed and to cause a flow of diluent through the by-pass or passes into compartment 16. During this movement of the parts, air would be vented through the pierced stopper 12. Now by agitating the ampule or vial a proper solution would be prepared. Under these circumstances the parts might, for example, be in the positions shown in Fig. 2. Now by simply aspirating the syringe with which the piercing needle is associated the solution could be drawn into the barrel of that syringe. Thereafter the needle could be withdrawn and the injection proceeded with. If any difficulties were experienced in connection with aspiration or withdrawal of the solution from the body of the device then stopper 11 could conveniently be shifted somewhat to the right of the position shown in Fig. 2 so that too great a condition of vacuum would not arise in compartment 16. Also as is apparent, both stoppers 11 and 14 might be shifted as a unit during the withdrawal action of the solution and as indicated in Fig. 3. As will be understood in connection with both of the described structures, a by-pass provision is, in each instance, illustrated. This functions-in cooperation with the adjacent stopperto permit an intermixing of the diluent and medicament in the different compartments as that stopper is shifted. In both instances, the ampule is non-circular in cross section at a point intermediate its ends. In other words, in one form the continuity of the surface is interrupted by a groove or grooves while in the other form an elliptical or oval surface is presented.
Thus, among others, the several objects of the invention as specifically aforenoted are achieved. Obviously numerous changes in construction and rearrangement of 1 the parts might be resorted to without departing from the spirit of the invention as defined by the claims.
I claim:
1. An ampule including a tubular body, the bore of said body at a zone intermediate its ends being oval in cross section to provide relatively recessed portions, said portions furnishing a by-pass for liquid normally confined within the bore and to the rear of a resilient stopper as the latter is shifted axially of the bore in the zone of said portions.
2. An ampule for removable disposal in a needlemounting syringe, said ampule including a tubular openended body circular in section adjacent at least one end, the bore of said body at a zone intermediate its ends being formed with a longitudinally extending groove in its face, a stopper adjacent said groove, the latter providing a by-pass for liquid normally confined within the bore and to the rear of said stopper as the latter is shifted axially of the bore into the zone of said by-pass, said bore adjacent one end of said body providing a seat, a piston type stopper cooperating therewith to provide a liquidtight seal, the opposite end of said body furnishing a second seat, a pierceable type stopper cooperating therewith, and edge means on said latter-named end for engagement with the internal end portion of a needlemounting syringe.
3. An ampule for removable disposal in a needlemounting syringe, said ampule including a tubular openended body circular in section adjacent at least one end, the bore of said body at a zone intermediate its ends having at least a portion of its inner face spaced from the ampule axis a distance greater than at other points to provide a by-pass for liquid, a stopper within said bore adjacent said zone, said stopper confining liquid within the bore and to the rear of said stopper as the latter is shifted axially of the bore into the zone of said by-pass, said bore adjacent one end of said body'providing a seat, a pistontype stopper cooperating therewith to provide a liquidtight seal, the opposite end of said body furnishing a second seat, a pierceable type stopper cooperating therewith, and edge means on said latter-named end for engagement with the internal end portion of a needle-mounting syringe.
4. An ampule for removable disposal in a needlemounting syringe, said ampule including a tubular openended body circular in section adjacent at least one end, the bore of said body at a zone intermediate its ends being formed with a longitudinally extending groove in its face to provide a by-pass for liquid normally confined within the bore, a stopper disposed adjacent said groove and providing a partition intermediate with ends of said body, a piston stopper adjacent one end of said bore and spaced from said first named stopper to furnish a compartment between the same, diluent within said compartment, said diluent flowing through said by-pass as said piston stopper is shifted axially of the bore to cause similar shifting of said first-named stopper in the zone of said groove, a pierceable type stopper adjacent the opposite end of said body and beyond said groove to provide a medicament compartment to receive the diluent flowing through said bypass, said bore furnishing seats for liquidtight seals for each of said stoppers at the normal positions of same, and edge means at the end of said body containing said pierceable stopper for engagement with the internal end portions of said needle-mounting syringe.
References Cited inthe file of this patent UNITED STATES PATENTS 1,909,591 Nevin May 16, 1933 1,929,247 Hein Oct. 3, 1933 2,102,704 Hein Dec. 21, 1937 2,549,417 Brown Apr. 17, 1951 2,591,046 Brown Apr. 1, 1952
US216058A 1949-08-10 1951-03-16 Syringe ampule Expired - Lifetime US2717601A (en)

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US109430A US2549417A (en) 1949-08-10 1949-08-10 Syringe ampoule
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Cited By (44)

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US2845067A (en) * 1955-07-01 1958-07-29 Gabriel Daniel Vials containing medication under pressure
US2896622A (en) * 1955-05-03 1959-07-28 Gruenenthal Chemie Injection ampoules for several media and intended to be used once
US2907329A (en) * 1955-01-26 1959-10-06 Milton J Cohen Hypodermic syringe
US3058467A (en) * 1958-10-27 1962-10-16 Faure Jean-Marie Hypodermic syringes
US3076456A (en) * 1960-03-07 1963-02-05 Elsie B Hunt Hypodermic syringe
DE1242796B (en) * 1964-10-31 1967-06-22 Penicillin Ges Dauelsberg & Co Two-chamber syringe
US3480014A (en) * 1966-09-15 1969-11-25 American Cyanamid Co Method for ointment storage and dispensing
US3674028A (en) * 1969-06-04 1972-07-04 Ims Ltd Multi-mix
US3785481A (en) * 1970-08-12 1974-01-15 Goupil J Multi-chamber container
FR2194453A1 (en) * 1972-08-04 1974-03-01 Alter Richard
US3796303A (en) * 1967-05-05 1974-03-12 Goupil J Containers
US3809225A (en) * 1969-05-02 1974-05-07 Goupil J Containers
EP0072057A1 (en) * 1981-08-10 1983-02-16 Duphar International Research B.V Automatic injection syringe
EP0072058A1 (en) * 1981-08-10 1983-02-16 Duphar International Research B.V Multiple-compartment syringe
US4479578A (en) * 1981-04-09 1984-10-30 The West Company Single barrel two-compartment medicament container assembly
US4552266A (en) * 1978-08-14 1985-11-12 Johnson & Johnson Disposable dental capsule
US4613326A (en) * 1985-07-12 1986-09-23 Becton, Dickinson And Company Two-component medication syringe assembly
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US4792329A (en) * 1985-06-27 1988-12-20 Duphar International Research B.V. Multi-compartment syringe
EP0298067A1 (en) * 1987-07-02 1989-01-04 Kabi Pharmacia Ab Method and device for injection
US4952208A (en) * 1987-07-21 1990-08-28 Wasserburger Arzneimittelwerk Dr. Madaus Gmbh & Co. Kg Injection syringe for medical purposes
US5110215A (en) * 1990-12-21 1992-05-05 Temple University Container for liquid crystal cumulative dosimeter
US5158364A (en) * 1990-12-21 1992-10-27 Temple University Method of making and using an improved liquid crystal cumulative dosimeter container
EP1225938A1 (en) * 1999-10-22 2002-07-31 Antares Pharma, Inc. Medicament cartridge and injection device
US20040054327A1 (en) * 2000-12-21 2004-03-18 Innoject Holdings, Inc. Automatic mixing and injecting apparatus
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US20040134563A1 (en) * 1999-10-22 2004-07-15 Antares Pharma, Inc. Medical injector and medicament loading system for use therewith
US20060178641A1 (en) * 2004-12-03 2006-08-10 Reynolds David L Extensible plunger rod for pharmaceutical delivery device
US20070185440A1 (en) * 2005-09-05 2007-08-09 Hiroshi Matsumto Injection device
US20110257605A1 (en) * 2010-04-16 2011-10-20 Kloehn, Inc. Self-centering syringe assembly and centering syringe plunger guide
US20120071836A1 (en) * 2009-04-30 2012-03-22 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
US20140163478A1 (en) * 2011-08-02 2014-06-12 Sanofi-Aventis Deutschland Gmbh Drug Delivery Device and Cartridge to be Interconnected Therewith
US8915889B2 (en) 2008-08-05 2014-12-23 Antares Pharma, Inc. Multiple dosage injector
US8945063B2 (en) 2009-03-20 2015-02-03 Antares Pharma, Inc. Hazardous agent injection system
US9180259B2 (en) 2005-01-24 2015-11-10 Antares Pharma, Inc. Prefilled syringe jet injector
US9220660B2 (en) 2011-07-15 2015-12-29 Antares Pharma, Inc. Liquid-transfer adapter beveled spike
US9333309B2 (en) 2002-02-11 2016-05-10 Antares Pharma, Inc. Intradermal injector
US9364610B2 (en) 2012-05-07 2016-06-14 Antares Pharma, Inc. Injection device with cammed ram assembly
US9446195B2 (en) 2011-07-15 2016-09-20 Antares Pharma, Inc. Injection device with cammed ram assembly
US9707354B2 (en) 2013-03-11 2017-07-18 Antares Pharma, Inc. Multiple dosage injector with rack and pinion dosage system
US9744302B2 (en) 2013-02-11 2017-08-29 Antares Pharma, Inc. Needle assisted jet injection device having reduced trigger force
US9808582B2 (en) 2006-05-03 2017-11-07 Antares Pharma, Inc. Two-stage reconstituting injector
US9950125B2 (en) 2012-04-06 2018-04-24 Antares Pharma, Inc. Needle assisted jet injection administration of testosterone compositions
US20180110604A1 (en) * 2015-06-03 2018-04-26 Imv Technologies Straw for the preservation of a predetermined dose of liquid-based substance, as well as a method and injection device that employ it

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US1929247A (en) * 1931-01-20 1933-10-03 George N Hein Syringe equipment and apparatus
US2102704A (en) * 1935-06-10 1937-12-21 George N Hein Syringe cartridge
US2549417A (en) * 1949-08-10 1951-04-17 Frederick M Turnbull Syringe ampoule
US2591046A (en) * 1948-10-18 1952-04-01 Frederick M Turnbull Hypodermic syringe assembly

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US1909591A (en) * 1928-06-20 1933-05-16 Novocol Chemical Mfg Co Inc Method of utilizing hypodermic medicaments, etc.
US1929247A (en) * 1931-01-20 1933-10-03 George N Hein Syringe equipment and apparatus
US2102704A (en) * 1935-06-10 1937-12-21 George N Hein Syringe cartridge
US2591046A (en) * 1948-10-18 1952-04-01 Frederick M Turnbull Hypodermic syringe assembly
US2549417A (en) * 1949-08-10 1951-04-17 Frederick M Turnbull Syringe ampoule

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