US2559793A - Beta irradiation method and means - Google Patents
Beta irradiation method and means Download PDFInfo
- Publication number
- US2559793A US2559793A US73080A US7308049A US2559793A US 2559793 A US2559793 A US 2559793A US 73080 A US73080 A US 73080A US 7308049 A US7308049 A US 7308049A US 2559793 A US2559793 A US 2559793A
- Authority
- US
- United States
- Prior art keywords
- radium
- applicator
- beta
- rays
- beta rays
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1014—Intracavitary radiation therapy
- A61N5/1017—Treatment of the eye, e.g. for "macular degeneration"
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G4/00—Radioactive sources
- G21G4/04—Radioactive sources other than neutron sources
- G21G4/06—Radioactive sources other than neutron sources characterised by constructional features
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1089—Electrons
Definitions
- This invention relates to the use of pure beta irradiation or substantially pure beta irradiation for therapeutic purposes, and more particularly for ophthalmic purposes.
- a radon applicator for the treatment of certain lesions of the eyelids and anterior ocular segments, and such treatment has been extensively tested at the Eye Department of the Cleveland Clinic with (Cleveland Clinic Quarterly, April, 1946).
- the radon applicator has required the use of a 250-275 millicurie radon glass bulb applicator, having a diameter of 5 millimeters and a wall thickness of one millimeter. This radon technique could be duplicated only in a few large medical centers.
- the physician is not endangered by continuous exposure to penetrating gamma rays, and no essential radiation reaches the crystalline lens of the patient. Also, an applicator which emits substantially no gamma rays can be easily stored, because one millimeter of lead blocks out all essential radiation.
- Radium element disintegrates to produce radon gas, which disintegrates to produce a series of disintegration products.
- Radium E which has an atomic weight of 210, an atomic number of 83, and a half-life of five days.
- Radium E emits beta and gamma rays.
- the maximum energy of the beta rays emitted by radium E is about 1.17 Mev.
- Radium E disintegrates to produce radium F, also designated as polonium, which emits alpha rays, with a feeble emission of beta rays.
- the improved applicator is a circular silver foil or plaque, whose radio-active diameter is 5.6 millimeters and whose thickness is one millimeter.
- This disc-shaped plaque has 25 square millimeters of active surface area.
- This plaque is provided with a filter or Window of aluminum, whose thickness is 0.05 millimeter.
- This plaque fits closely in the recess of a holder body which is made of Monel metal.
- Monel metal contains 60%-70% nickel; 25%35% copper; 1%-3% iron; 0.25%-2% manganese; 0.02%-1.5% silicon; 0.3%-0.5% carbon.
- This plaque contains 10 millicuries of radium D, although variable concentrations of radium D may be used.
- a 10 millicurie applicator of this size contains 800% of the amount of radioactive material per squire millimeter of surface area, as compared with a full-strength radium-element plaque, in which the radium-element has an atomic weight of 226, and an atomic number of 88.
- the aluminum filter can be replaced by other filtering material of low filtering density, such as mica. Monel metal can also be used.
- the density of this preferred aluminum filter is about 16% of the density of a filter of Monel metal which has a thickness of 0.1 millimeter, thus greatly increasing the effective beta ray output.
- the electro-magnetic radiation consists mainly of a feeble, low energy gamma radiation from radium D, and from Bermsstrahlung, namely, from the continuous X-rays which are produced by the interaction of the beta rays of the radium E with the Monel metal backing of the applicator.
- the maximum ionization of these gamma rays and X-rays is less than one-tenth per cent of the ionization due to the emitted beta rays.
- the beta ray output which is produced substantially Wholly by the high energy beta rays of radium E, averages about 11,000 equivalent lr'ltoentgens (rep) of surface beta ray dosage per our.
- radium E Since radium E is in equilibrium in the applicator with radium D, the beta ray activity decreases with a half -period of 22.2 years, which is characteristic of radium D.
- the filter completely absorbs the soft beta radiation of radium F (polonium) Substantially only the penetrating beta rays of radium E emerge from the applicator.
- beta rays which are thus emitted, have the same qualities as gamma rays, in selective tissue destruction, but penetrate only 3-4 millimeters of tissue, thus making it possible to treat superficial conditions without endangering the lens, and preventing possible formation of a cataract.
- beta rays The greatest effect of these emitted beta rays is superficial, because their effect is inversely proportional to the square of the distance from the source.
- a 4-5 minute contact is used in treating vascularizations of the cornea, and the treatments may be repeated at intervals of 2-4 weeks.
- the applicator should be placed as close to the lesion as possible, preferably in contact with the tissue.
- Fig. 1 is a diagrammatic cross-section, not to scale, of one embodiment of the improved applicator
- Fig. 2 is a front end-view.
- Fig. 3 is a rear end-view.
- This applicator comprises a cylindrical body I, which is made of Monel metal. At its front, said body I has a cylindrical recess or cavity, whose diameter is 5.6 millimeters and whose depth is one millimeter.
- a silver foil or plaque 2 fits snugly in this recess.
- the thickness of the annular wall la of said recess is 1.7 millimeter.
- This disc-shaped foil or plaque 2 contains 10 millicuries of radium D, although this concentration may be varied.
- This filter 3 is held in place by the fiange 4a of a collar 4, which is made of Monel metal, and which has a thickness of 0.1 millimeter.
- the flange 4a is of minimum diameter. Said collar 4 fits snugly on body I.
- the initial length of the cylindrical body of collar 4 exceeds the length of body I. After collar 4 has been applied, it is soldered to body I at the rear face 5 of body I. The collar 4 is then cut transversely to be flush with rear face 5. Said rear face 5 has a tapped recess 5a, and the threaded end of a handle, not shown, may be fixed detachably to the internally threaded wall of recess 5a.
- the active diameter of the plaque 2 in the finished applicator is substantially 5.6 millimeters, with an active surface of substantially 25 square millimeters.
- the improved applicator therefore has a radioactive source which consists substantially of radium D in equilibrium with radium E, so as to deliver substantially constant beta rays over a long period. While some polonium is produced in the applicator, its effect is insignificant.
- the filter preferably blocks the alpha rays which are emitted by the polonium which results from the disintegration of the radium E.
- the thin carrier 2 is permeable to the beta rays of radium E, so that the entire mass of carrier 2 emits the beta rays of radium E.
- the parent radium D is optionally and preferably uniformly incorporated in the entire mass of the carrier 2.
- the length of body I is about 3 to 4 inches, so that when solder is applied at rear face 5, the heat of the soldering operation will not affect the thin carrier 2 or the thin filter 3.
- each element 3 is preferably and optionally imperforate, in order to block the undesired radiation.
- the radium D may be deposited upon the surface of the carrier 2, as an alternative to impregnating carrier 2 with the radium D.
- Electro-deposition may be used for depositing the radium D upon the surface of carrier 2.
- a salt of radium D and a salt of lead are dissolved in water, in order to provide an electrolytic bath.
- I can use the nitrate or chloride of radium D, and the nitrate or chloride of lead.
- I'thus produce a co-deposit of radium D and lead by electrolysis upon the surface of the metal carrier 2, which is preferably the cathode.
- An ophthalmic applicator which has radioactive material which consists substantially wholly of radium D and radium E and radium F, said applicator having filter means which are permeable substantially only to beta rays emitted at the energy level of the beta rays emitted by radium E.
- a method of treating living eye tissue which consists in applying substantially only the beta rays emitted substantially only by radium E to said living tissue, the maximum energy of said emitted beta rays being substantially 1.17 Mev.
- An ophthalmic applicator which has a radio-active source which consists substantially Wholly of radium D, radium E and radium F, said radium E and radium F being the disintegration 5 products of original radium D of said source, said source originally having at least substantially 0.4 millicurie of radium D per square millimeter of active surface area, said applicator having a filter which is permeable substantially only to the beta rays emitted substantially only by radium E, the maximum energy of said emitted beta rays being substantially 1.17 Mev.
Description
July 10, 1951 A. PREGEL 2559393 BETA IRRADIATION METHOD AND MEANS Filed Jan. 27. 1949 INVENTOR Alexander pregel ATTORNEY good results.
Patented July 10, 1951 BETA IRRADIATION METHOD AND MEANS Alexander Pregel, New York, N. Y., assignor to' Canadian Radium and Uranium Corporation, New York, N. Y., a corporation of New York Application January 27, 1949, Serial No. 73,080
5 Claims.
This invention relates to the use of pure beta irradiation or substantially pure beta irradiation for therapeutic purposes, and more particularly for ophthalmic purposes.
It has heretofore been proposed to use a radon applicator for the treatment of certain lesions of the eyelids and anterior ocular segments, and such treatment has been extensively tested at the Eye Department of the Cleveland Clinic with (Cleveland Clinic Quarterly, April, 1946). The radon applicator has required the use of a 250-275 millicurie radon glass bulb applicator, having a diameter of 5 millimeters and a wall thickness of one millimeter. This radon technique could be duplicated only in a few large medical centers.
Tests have shown that the elimination of the gamma ray radiation of the radon applicator is a great advantage to the physician and the patient, and that pure beta rays are effective for treating many ophthalmic conditions.
By eliminating the gamma ray radiation, the physician is not endangered by continuous exposure to penetrating gamma rays, and no essential radiation reaches the crystalline lens of the patient. Also, an applicator which emits substantially no gamma rays can be easily stored, because one millimeter of lead blocks out all essential radiation.
The improved applicator and the tests and uses thereof are described in the Mississippi Valley Medical Journal and Radiologic Review vol. '70, pp. 71-72 (March, 1948) and in the November 1948 issue of First Annual Radiation Therapy Number of the Mississippi Valley Medical Journal and Radiologic Review.
As stated therein, the use of radium element was tried, but it was not possible to concentrate enough of radium element in a small applicator to give the treatment rapidly.
Radium element disintegrates to produce radon gas, which disintegrates to produce a series of disintegration products.
Radium D disintegrates to produce radium E,
which has an atomic weight of 210, an atomic number of 83, and a half-life of five days. Radium E emits beta and gamma rays. The maximum energy of the beta rays emitted by radium E is about 1.17 Mev.
Radium E disintegrates to produce radium F, also designated as polonium, which emits alpha rays, with a feeble emission of beta rays.
As one example, the improved applicator is a circular silver foil or plaque, whose radio-active diameter is 5.6 millimeters and whose thickness is one millimeter.
This disc-shaped plaque has 25 square millimeters of active surface area. This plaque is provided with a filter or Window of aluminum, whose thickness is 0.05 millimeter. This plaque fits closely in the recess of a holder body which is made of Monel metal. As described at page 444 of the 1942 edition of The Condensed Chemical Dictionary published by Reinhold Publishing Corporation, Monel metal contains 60%-70% nickel; 25%35% copper; 1%-3% iron; 0.25%-2% manganese; 0.02%-1.5% silicon; 0.3%-0.5% carbon.
This plaque contains 10 millicuries of radium D, although variable concentrations of radium D may be used.
A 10 millicurie applicator of this size contains 800% of the amount of radioactive material per squire millimeter of surface area, as compared with a full-strength radium-element plaque, in which the radium-element has an atomic weight of 226, and an atomic number of 88.
The aluminum filter can be replaced by other filtering material of low filtering density, such as mica. Monel metal can also be used.
The density of this preferred aluminum filter is about 16% of the density of a filter of Monel metal which has a thickness of 0.1 millimeter, thus greatly increasing the effective beta ray output.
. Tests have shown that a few feeble gamma rays are emitted by the improved applicator. Such tests have shown that this applicator is a source of substantially pure beta radiation. The electro-magnetic radiation consists mainly of a feeble, low energy gamma radiation from radium D, and from Bermsstrahlung, namely, from the continuous X-rays which are produced by the interaction of the beta rays of the radium E with the Monel metal backing of the applicator. The maximum ionization of these gamma rays and X-rays is less than one-tenth per cent of the ionization due to the emitted beta rays.
Since more than 99.9 of the total ionization produced by all the radiations of the applicator is produced by beta rays, the presence of the very feeble gamma radiation having a quantum energy of only 0.047 Mev. is therapeutically unimportant, and of no biologic effect in comparison with the 0 energetic beta rays of radium E, which have a maximum energy of about 1.17 Mev.
The beta ray output which is produced substantially Wholly by the high energy beta rays of radium E, averages about 11,000 equivalent lr'ltoentgens (rep) of surface beta ray dosage per our.
Since radium E is in equilibrium in the applicator with radium D, the beta ray activity decreases with a half -period of 22.2 years, which is characteristic of radium D. The filter completely absorbs the soft beta radiation of radium F (polonium) Substantially only the penetrating beta rays of radium E emerge from the applicator.
These beta rays which are thus emitted, have the same qualities as gamma rays, in selective tissue destruction, but penetrate only 3-4 millimeters of tissue, thus making it possible to treat superficial conditions without endangering the lens, and preventing possible formation of a cataract.
The greatest effect of these emitted beta rays is superficial, because their effect is inversely proportional to the square of the distance from the source.
Favorable tests have been made with the improved applicator for various eye conditions, such as (1) corneal scars, except those which are calcified or very dense; (2) corneal vascularizations from any cause; (3) papillomas of the lids; (4) hemangioma; (5) vernal conjunctivitis; (6) pterygium, if not too dense.
By eliminating or substantially eliminating gamma rays, it is possible to use a larger dosage of the beta rays.
When using the 10 millicurie applicator, a 4-5 minute contact is used in treating vascularizations of the cornea, and the treatments may be repeated at intervals of 2-4 weeks.
The applicator should be placed as close to the lesion as possible, preferably in contact with the tissue. I
Fig. 1 is a diagrammatic cross-section, not to scale, of one embodiment of the improved applicator;
Fig. 2 is a front end-view.
Fig. 3 is a rear end-view.
This applicator comprises a cylindrical body I, which is made of Monel metal. At its front, said body I has a cylindrical recess or cavity, whose diameter is 5.6 millimeters and whose depth is one millimeter.
A silver foil or plaque 2 fits snugly in this recess. The thickness of the annular wall la of said recess is 1.7 millimeter.
This disc-shaped foil or plaque 2 contains 10 millicuries of radium D, although this concentration may be varied. A filter 3, made of aluminum, and having a thickness of 0.05 millimeter, abuts the front annular face of wall la and the front wall of the disc-shaped foil or plaque 2.
This filter 3 is held in place by the fiange 4a of a collar 4, which is made of Monel metal, and which has a thickness of 0.1 millimeter. The flange 4a is of minimum diameter. Said collar 4 fits snugly on body I.
The initial length of the cylindrical body of collar 4 exceeds the length of body I. After collar 4 has been applied, it is soldered to body I at the rear face 5 of body I. The collar 4 is then cut transversely to be flush with rear face 5. Said rear face 5 has a tapped recess 5a, and the threaded end of a handle, not shown, may be fixed detachably to the internally threaded wall of recess 5a.
The active diameter of the plaque 2 in the finished applicator is substantially 5.6 millimeters, with an active surface of substantially 25 square millimeters.
The improved applicator therefore has a radioactive source which consists substantially of radium D in equilibrium with radium E, so as to deliver substantially constant beta rays over a long period. While some polonium is produced in the applicator, its effect is insignificant.
The filter preferably blocks the alpha rays which are emitted by the polonium which results from the disintegration of the radium E.
The thin carrier 2 is permeable to the beta rays of radium E, so that the entire mass of carrier 2 emits the beta rays of radium E.
The parent radium D is optionally and preferably uniformly incorporated in the entire mass of the carrier 2.
The length of body I is about 3 to 4 inches, so that when solder is applied at rear face 5, the heat of the soldering operation will not affect the thin carrier 2 or the thin filter 3.
While element 3 may be a window, each element 3 is preferably and optionally imperforate, in order to block the undesired radiation.
The radium D may be deposited upon the surface of the carrier 2, as an alternative to impregnating carrier 2 with the radium D.
Electro-deposition may be used for depositing the radium D upon the surface of carrier 2.
For this purpose, a salt of radium D and a salt of lead are dissolved in water, in order to provide an electrolytic bath. I can use the nitrate or chloride of radium D, and the nitrate or chloride of lead.
I'thus produce a co-deposit of radium D and lead by electrolysis upon the surface of the metal carrier 2, which is preferably the cathode.
This method of simultaneously electro-depositing radium D and lead on a metal carrier is Wellknown per se, so that the details thereof, such as the proper pH of the electrolytic bath, are not described herein.
I have. described preferred embodiments of my invention, but numerous changes and substitutions and omissions and additions can be made without departing from its scope.
I claim:
1. An ophthalmic applicator which has radioactive material which consists substantially wholly of radium D and radium E and radium F, said applicator having filter means which are permeable substantially only to beta rays emitted at the energy level of the beta rays emitted by radium E.
2. An ophthalmic applicator according to claim 1, in which said betay ray output is substantially 11,000 equivalent Roentgens (rep) of surface beta ray dosage per hour.
3. An ophthalmic applicator according to claim 1, in which said radium E and radium F are the successive derived disintegration products of radium D originally incorporated in said applicator, said derived radium E being in equilibrium with said original radium D.
4. A method of treating living eye tissue which consists in applying substantially only the beta rays emitted substantially only by radium E to said living tissue, the maximum energy of said emitted beta rays being substantially 1.17 Mev.
5. An ophthalmic applicator which has a radio-active source which consists substantially Wholly of radium D, radium E and radium F, said radium E and radium F being the disintegration 5 products of original radium D of said source, said source originally having at least substantially 0.4 millicurie of radium D per square millimeter of active surface area, said applicator having a filter which is permeable substantially only to the beta rays emitted substantially only by radium E, the maximum energy of said emitted beta rays being substantially 1.17 Mev.
ALEXANDER PREGEL.
REFERENCES CITED The following references are of record in the file of this patent:
OTHER REFERENCES Atomic PhysicsUniversity of Pittsburgh Staff Members-1937-pages 234-241-Pub1ished by John Wiley & Sons, Inc. New York, New York.
Claims (1)
1. AN OPHTHALMIC APPLICATOR WHICH HAS RADIOACTIVE MATERIAL WHICH CONSISTS SUBSTANTIALLY WHOLLY OF RADIUM D AND RADIUM E AND RADIUM F, SAID APPLICATOR HAVING FILTER MEANS WHICH ARE PERMEABLE SUBSTANTIALLY ONLY TO BETA RAYS EMITTED AT THE ENERGY LEVEL OF THE BETA RAYS EMITTED BY RADIUM E.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73080A US2559793A (en) | 1949-01-27 | 1949-01-27 | Beta irradiation method and means |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73080A US2559793A (en) | 1949-01-27 | 1949-01-27 | Beta irradiation method and means |
Publications (1)
Publication Number | Publication Date |
---|---|
US2559793A true US2559793A (en) | 1951-07-10 |
Family
ID=22111596
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US73080A Expired - Lifetime US2559793A (en) | 1949-01-27 | 1949-01-27 | Beta irradiation method and means |
Country Status (1)
Country | Link |
---|---|
US (1) | US2559793A (en) |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2797333A (en) * | 1953-07-24 | 1957-06-25 | Armour Res Found | X-ray source |
US2964628A (en) * | 1953-10-13 | 1960-12-13 | Ohmart Corp | Radiation source for density responsive apparatus |
US2992980A (en) * | 1957-05-16 | 1961-07-18 | Exxon Research Engineering Co | Apparatus for radiation promoted processes |
US5141487A (en) * | 1985-09-20 | 1992-08-25 | Liprie Sam F | Attachment of radioactive source and guidewire in a branchy therapy source wire |
US5351689A (en) * | 1990-09-18 | 1994-10-04 | University Of Guelph | Method and apparatus for low dose estimates of bone minerals in vivo gamma ray backscatter |
US20040138515A1 (en) * | 2003-01-15 | 2004-07-15 | Jack White | Brachytherapy devices and methods of using them |
US20050177019A1 (en) * | 2001-02-22 | 2005-08-11 | Dejuan Eugene Jr. | Ophthalmic treatment apparatus |
US20060111605A1 (en) * | 2004-02-12 | 2006-05-25 | Larsen Charles E | Methods and apparatus for intraocular brachytherapy |
US20070055089A1 (en) * | 2004-02-12 | 2007-03-08 | Larsen Charles E | Methods and apparatus for intraocular brachytherapy |
US20080166297A1 (en) * | 2004-12-01 | 2008-07-10 | Dong Wha Pharm. Ind. Co., Ltd. | Radionuclide-Chitosan Complex Having an Improved Stablilized Gelatin in Administering Them to the Body and Their Preparation Method |
EP1997532A1 (en) | 2007-05-28 | 2008-12-03 | Seoul National University Hospital | Ophthalmic applicator for treatment of pterygium or glaucoma using 32-P alone or in combination with 103-Pd |
US7803103B2 (en) | 2005-02-11 | 2010-09-28 | Neovista Inc. | Methods and apparatus for intraocular brachytherapy |
US8353812B2 (en) | 2008-06-04 | 2013-01-15 | Neovista, Inc. | Handheld radiation delivery system |
US8430804B2 (en) | 2008-01-07 | 2013-04-30 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
USD691270S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
USD691269S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
USD691267S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
USD691268S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
US9056201B1 (en) | 2008-01-07 | 2015-06-16 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
US20160306069A1 (en) * | 2013-03-20 | 2016-10-20 | Geoservices Equipements Sas | Radiation source device |
USD808529S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
USD808528S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
USD814637S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD814638S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD815285S1 (en) | 2016-05-11 | 2018-04-10 | Salutaris Medical Devices, Inc. | Brachytherapy device |
US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
US20210379403A9 (en) * | 2017-09-07 | 2021-12-09 | Radiance Therapeutics, Inc. | Methods, systems, and compositions for maintaining functioning drainage blebs associated with minimally invasive micro sclerostomy |
US11383101B2 (en) * | 2019-09-27 | 2022-07-12 | Carl Zeiss Meditec Ag | Applicator, applicator system and method for using an applicator with a radiotherapy device |
US11628310B2 (en) | 2017-09-07 | 2023-04-18 | Radiance Therapeutics, Inc. | Methods, systems, and compositions for maintaining functioning drainage blebs associated with foreign bodies |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US839061A (en) * | 1905-02-23 | 1906-12-18 | Henri Farjas | Apparatus for application of salts of radium. |
AT81068B (en) * | 1916-04-22 | 1921-08-25 | Heinrich Tscholnitz Ing Heinri | Row-wise arrangement of emanation-developing K-capsules in rows, with the interposition of protective filter capsules, with the interposition of protective filters .. |
US1654888A (en) * | 1926-03-25 | 1928-01-03 | King Francis | Ophthalmic massage instrument |
US2326631A (en) * | 1941-08-15 | 1943-08-10 | United States Radium Corp | Radioactive unit and method of producing the same |
-
1949
- 1949-01-27 US US73080A patent/US2559793A/en not_active Expired - Lifetime
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US839061A (en) * | 1905-02-23 | 1906-12-18 | Henri Farjas | Apparatus for application of salts of radium. |
AT81068B (en) * | 1916-04-22 | 1921-08-25 | Heinrich Tscholnitz Ing Heinri | Row-wise arrangement of emanation-developing K-capsules in rows, with the interposition of protective filter capsules, with the interposition of protective filters .. |
US1654888A (en) * | 1926-03-25 | 1928-01-03 | King Francis | Ophthalmic massage instrument |
US2326631A (en) * | 1941-08-15 | 1943-08-10 | United States Radium Corp | Radioactive unit and method of producing the same |
Cited By (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2797333A (en) * | 1953-07-24 | 1957-06-25 | Armour Res Found | X-ray source |
US2964628A (en) * | 1953-10-13 | 1960-12-13 | Ohmart Corp | Radiation source for density responsive apparatus |
US2992980A (en) * | 1957-05-16 | 1961-07-18 | Exxon Research Engineering Co | Apparatus for radiation promoted processes |
US5141487A (en) * | 1985-09-20 | 1992-08-25 | Liprie Sam F | Attachment of radioactive source and guidewire in a branchy therapy source wire |
US5351689A (en) * | 1990-09-18 | 1994-10-04 | University Of Guelph | Method and apparatus for low dose estimates of bone minerals in vivo gamma ray backscatter |
US20050177019A1 (en) * | 2001-02-22 | 2005-08-11 | Dejuan Eugene Jr. | Ophthalmic treatment apparatus |
US7276019B2 (en) | 2001-02-22 | 2007-10-02 | Retinalabs, Inc. | Ophthalmic treatment apparatus |
US20060142629A1 (en) * | 2001-02-22 | 2006-06-29 | Dejuan Eugene Jr | Intraocular radiotherapy treatment for macular degeneration |
US8100818B2 (en) | 2001-02-22 | 2012-01-24 | TDH Partners, Inc. | Beta radiotherapy emitting surgical device and methods of use thereof |
US7220225B2 (en) | 2001-02-22 | 2007-05-22 | Retinalabs, Inc. | Intraocular radiotherapy treatment |
US7223225B2 (en) | 2001-02-22 | 2007-05-29 | Retinalabs, Inc. | Intraocular radiotherapy treatment for macular degeneration |
US20040138515A1 (en) * | 2003-01-15 | 2004-07-15 | Jack White | Brachytherapy devices and methods of using them |
US7070554B2 (en) * | 2003-01-15 | 2006-07-04 | Theragenics Corporation | Brachytherapy devices and methods of using them |
US20070055089A1 (en) * | 2004-02-12 | 2007-03-08 | Larsen Charles E | Methods and apparatus for intraocular brachytherapy |
US8365721B2 (en) | 2004-02-12 | 2013-02-05 | Neovista Inc. | Methods and apparatus for intraocular brachytherapy |
US7563222B2 (en) | 2004-02-12 | 2009-07-21 | Neovista, Inc. | Methods and apparatus for intraocular brachytherapy |
US7744520B2 (en) | 2004-02-12 | 2010-06-29 | Neovista, Inc. | Method and apparatus for intraocular brachytherapy |
US7803102B2 (en) | 2004-02-12 | 2010-09-28 | Neovista, Inc. | Methods and apparatus for intraocular brachytherapy |
US20060111605A1 (en) * | 2004-02-12 | 2006-05-25 | Larsen Charles E | Methods and apparatus for intraocular brachytherapy |
US7951060B2 (en) | 2004-02-12 | 2011-05-31 | Neovista, Inc. | Methods and apparatus for intraocular brachytherapy |
US20080166297A1 (en) * | 2004-12-01 | 2008-07-10 | Dong Wha Pharm. Ind. Co., Ltd. | Radionuclide-Chitosan Complex Having an Improved Stablilized Gelatin in Administering Them to the Body and Their Preparation Method |
US8292795B2 (en) | 2005-02-11 | 2012-10-23 | Neovista, Inc. | Methods and apparatus for intraocular brachytherapy |
US7803103B2 (en) | 2005-02-11 | 2010-09-28 | Neovista Inc. | Methods and apparatus for intraocular brachytherapy |
EP1997532A1 (en) | 2007-05-28 | 2008-12-03 | Seoul National University Hospital | Ophthalmic applicator for treatment of pterygium or glaucoma using 32-P alone or in combination with 103-Pd |
US9056201B1 (en) | 2008-01-07 | 2015-06-16 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
US8430804B2 (en) | 2008-01-07 | 2013-04-30 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
US9873001B2 (en) | 2008-01-07 | 2018-01-23 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
US10850118B2 (en) | 2008-01-07 | 2020-12-01 | Salutaris Medical Devices, Inc. | Methods and devices for minim ally-invasive delivery of radiation to the eye |
US10022558B1 (en) | 2008-01-07 | 2018-07-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive delivery of radiation to the eye |
US8597169B2 (en) | 2008-01-07 | 2013-12-03 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
US8353812B2 (en) | 2008-06-04 | 2013-01-15 | Neovista, Inc. | Handheld radiation delivery system |
USD691267S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
USD691268S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to eye |
USD691269S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
USD691270S1 (en) | 2009-01-07 | 2013-10-08 | Salutaris Medical Devices, Inc. | Fixed-shape cannula for posterior delivery of radiation to an eye |
US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
US20160306069A1 (en) * | 2013-03-20 | 2016-10-20 | Geoservices Equipements Sas | Radiation source device |
USD814637S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD814638S1 (en) | 2016-05-11 | 2018-04-03 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD815285S1 (en) | 2016-05-11 | 2018-04-10 | Salutaris Medical Devices, Inc. | Brachytherapy device |
USD808528S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
USD808529S1 (en) | 2016-08-31 | 2018-01-23 | Salutaris Medical Devices, Inc. | Holder for a brachytherapy device |
US20210379403A9 (en) * | 2017-09-07 | 2021-12-09 | Radiance Therapeutics, Inc. | Methods, systems, and compositions for maintaining functioning drainage blebs associated with minimally invasive micro sclerostomy |
US11628310B2 (en) | 2017-09-07 | 2023-04-18 | Radiance Therapeutics, Inc. | Methods, systems, and compositions for maintaining functioning drainage blebs associated with foreign bodies |
US11666780B2 (en) * | 2017-09-07 | 2023-06-06 | Radiance Therapeutics, Inc. | Methods, systems, and compositions for maintaining functioning drainage blebs associated with minimally invasive micro sclerostomy |
US11383101B2 (en) * | 2019-09-27 | 2022-07-12 | Carl Zeiss Meditec Ag | Applicator, applicator system and method for using an applicator with a radiotherapy device |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US2559793A (en) | Beta irradiation method and means | |
US3351049A (en) | Therapeutic metal seed containing within a radioactive isotope disposed on a carrier and method of manufacture | |
Kruger | Some biological effects of nuclear disintegration products on neoplastic tissue | |
Tobias et al. | Radiological physics characteristics of the extracted heavy ion beams of the bevatron | |
Scalliet et al. | Which RBE for iodine 125 in clinical applications? | |
Schultz et al. | Management of presumptive or proven Hodgkin's disease of the liver: A new radiotherapy technique | |
Williams et al. | The RBE of megavoltage photon and electron beams | |
Nakahara et al. | STUDIES ON X-RAY EFFECTS: X. The Biological Action of Small Doses of Low Frequency X-Rays. | |
Wright et al. | Physical aspects of megavolt electron therapy | |
Skaggs et al. | Development of the betatron for electron therapy | |
Rustgi | Dose distribution under external eye shields for high energy electrons | |
Deeley et al. | Treatment of Malignant Disease of the Nasal Sinuses by Supervolgate Radiotheraphy | |
Krohmer | Patient dose distributions during hypocycloidal tomography | |
Hale | The homogeneity factor for pulsating potential X-ray beams in the diagnostic energy region | |
Thoraeus | Cesium 137 and its gamma radiation in teleradiotherapy | |
Elmanharawy | Experimental comparison of dosimetric data for yttrium oxide (Y90) rods | |
Lawrence et al. | Heavy particles in experimental medicine and therapy | |
Goldberg | Area factor in roentgen irradiation | |
Sklaroff | Treatment of hemangiomas with the strontium-90 beta-ray applicator | |
Gurtovoi et al. | Visual sensations induced by X-irradiation of the eye with doses of the order of one milliroentgen | |
Ovadia et al. | Dose distribution in grid therapy with 15-to 33-Mev electrons | |
Duncan et al. | Considerations on the use of 14 MeV neutrons for radiotherapy | |
Parker | Dosage Measurements by Simple Computations | |
Peter | Therapy with Ionizing Radiation | |
Haas et al. | Modifications of depth dose curves of high energy x-ray and electron beams by interposed bone |