|Publication number||US2527686 A|
|Publication date||31 Oct 1950|
|Filing date||26 Dec 1945|
|Priority date||26 Dec 1945|
|Publication number||US 2527686 A, US 2527686A, US-A-2527686, US2527686 A, US2527686A|
|Inventors||Sandberg Max H|
|Original Assignee||Sandberg Max H|
|Export Citation||BiBTeX, EndNote, RefMan|
|Patent Citations (6), Referenced by (45), Classifications (26)|
|External Links: USPTO, USPTO Assignment, Espacenet|
Patented Oct. 31 1950 MOUTHWASH Max H. Sandberg, MattapamlMass.
Application December 26, 1945, Serial No. 637,257
This invention relates to mouth washes and particularly to compositions of this character which may be utilized to have a very eflicacious effect against dental caries.
Among the objects of the present invention is the production of compositions which can be utilized as mouth washes to prevent development of cavities in teeth.
Other objects and advantages will appear from the more detailed description set forth below, it being understood that such more detailed description is given by way of illustration and explanation only, and not by way of limitation since various changes therein may be made by those skilled in the art without departing from the scope and spirit of the present invention.
In accordance with the present invention it has been found that water soluble fluorides particularly of the alkali metals may be utilized in proper vehicles as a mouth wash or for related purposes, in limited concentrations in such mouth washes, to have a beneficial effect against development of cavities in teeth. The fluorides employed are desirably alkali metal fluorides of which ammonium fluoride or ammonium bifluoride has been found to be the best, while the sodium fluoride can be utilized. Potassium fluoride is the less efficacious. The fluoride is utilized in the vehicle which enables it to be carried into the enamel rods.
In such composition there is employed papain which digests proteins and malt or diastase such as takadiastase which digests starches. These ferments may be employed in such composition and do not interfere with each other. Other ferments cannot be employed in lieu of the particular ferments mentioned above and those set forth, namely, the papain and malt must be employed to give the most desirable results in accordance with the present invention. Such ferments together with the fluorides are desirably used in an aqueous composition which also contains zinc chloride and formaldehyde, as for example, commercial formalin. The most desirable proportions have been found to be 1 mole of fluoride to 1 mole of zinc chloride to 1 mole of formaldehyde but other ratios may be employed. The amount of fluoride present should be carefully controlled and should lie within about to 30 grains per gallon of the final solution. Less than 15 grains per gallon does not give any substantial effect while more than 30 grains tends to give a mottling effect. The preferred range is from 15 to 25 grains per gallon.
The stated ingredients are desirably used in an aqueous vehicle and since zinc chloride has a tendency to decompose in the presence of water, a water-soluble non-toxic alcohol may desirably be added to prevent this efiect. Ethyl alcohol is preferred, isopropyl and similar alcohols may be employed. Variation in the amount of alcohol and water proportions may, of course, be employed, but less alcohol than that indicated tends to give some undesirable feeling on the gums.
Flavoring components as desired may be employed such as the flavoring oils like oil of cassia, oil of cloves, and saccharin may be included in small amounts. The composition may be colored with any suitable dye. If desired to impart a Wintergreen aroma, this may be done by permitting the composition to stand within an atmosphere containing such oil of Wintergreen for a period of about one week.
The following is a preferred formula:
Parts Zinc chloride 2 Formalin (commercial) .5
Papain -l 100 Malt 100 The flavoring ingredients and vehicle components include:
Parts Oil of cassia 1.5 Oil of cloves .5
Saccharin .5 Ethyl alcohol 40 'Water 1000 The materials may be mixed in any desired way and the fluoride added to produce the stated concentration of from 15 to grains per gallon of solution, desirably 25 grains of sodium or ammonium fluoride being added for this purpose. While the fluoride may be incorporated together with all of the other ingredients, it is desirable to add it as the final component. The parts given in this example are by weight.
Compositions produced in accordance with the present invention have been proven to be a specific in preventing the formation of dental caries. This invention being a prophylactic only, does not have any action .on dental caries that are in active progress.
Having thus set forth my invention, I claim:
1. A mouth Wash containing zinc chloride, formaldehyde, papain, malt and water, and an alkali metal fluoride in an amount of from 15 to 30 grains per gallon of solution.
2. A composition as set forth inclaim 1,-in which the fluoride is ammonium fluoride.
(3. A composition as set forth in claim 1, in which the fluoride is sodium fluoride.
4. A mouth wash as set forth in claim 1 containing an amount of a non-toxic aliphatic alcohol sufiicient to prevent decomposition of the zinc chloride.
5. A mouth wash containing the following components in parts by weight: zinc chloride 2, formalin .5, papain 100, malt 100, ethyl alcohol 40, water 1000, and an alkali metal fluoride in an amount of 25 grains per gallon of solution.
MAX H. SANDBERG.
REFERENCES CITED The following references are of record in the file of this patent:
Number 0 Number 4 UNITED STATES PATENTS Name Date Monroe Dec. 29, 1925 Cross Jan. 16, 1934 FOREIGN PATENTS Country Date France Dec. 1, 1910 Great Britain of 1914 Austria Apr. 10, 1922 Great Britain Apr. 13, 1942
|Cited Patent||Filing date||Publication date||Applicant||Title|
|US1567974 *||1 Jun 1923||29 Dec 1925||Wesley Monroe Charles||Treatment of pyorrhea|
|US1943856 *||10 Jul 1929||16 Jan 1934||Silica Products Company||Dental preparation|
|AT87896B *||Title not available|
|FR420705A *||Title not available|
|GB544405A *||Title not available|
|GB191403034A *||Title not available|
|Citing Patent||Filing date||Publication date||Applicant||Title|
|US2829086 *||21 Sep 1954||1 Apr 1958||Colgate Palmolive Co||Dental preparations comprising higher aliphatic perfluorinated acid compounds|
|US2913373 *||28 Aug 1957||17 Nov 1959||Fay Weisz Geraldine||Fluoride mouth wash composition|
|US3072532 *||4 Nov 1958||8 Jan 1963||Innerfield Irving||Administration of enzymic composition|
|US3852432 *||21 Aug 1972||3 Dec 1974||Department Of Health Education||Diagnostic device and method of treatment|
|US4082841 *||29 Oct 1976||4 Apr 1978||Lever Brothers Company||Dentifrice|
|US4096241 *||24 Jun 1976||20 Jun 1978||Ed. Geistlich Sohne A.G. Fur Chemische Industrie||Tooth preparations|
|US4152418 *||1 Dec 1977||1 May 1979||Lever Brothers Company||Zinc and enzyme mouthwash and mouthwash concentrate for reducing dental plaque and calculus formation|
|US4339432 *||17 Feb 1981||13 Jul 1982||Lever Brothers Company||Oral mouthwash containing zinc and glycine|
|US4416867 *||10 Feb 1982||22 Nov 1983||Lever Brothers Company||Oral compositions|
|US4469674 *||2 May 1983||4 Sep 1984||Richardson-Vicks Inc.||Stable oral compositions containing zinc and fluoride compounds|
|US4473550 *||3 Jan 1983||25 Sep 1984||Rosenbaum Robert S||Bactericidal compositions and methods|
|US4476108 *||7 Feb 1983||9 Oct 1984||Kessler Jack H||Bactericidal method|
|US4588586 *||18 Jun 1984||13 May 1986||Kessler Jack H||Method for disinfecting a contact lens|
|US4847089 *||19 Aug 1987||11 Jul 1989||David N. Kramer||Cleansing and distinfecting compositions, including bleaching agents, and sponges and other applicators incorporating the same|
|US5002970 *||18 Apr 1988||26 Mar 1991||Eby Iii George A||Flavor masked ionizable zinc compositions for oral absorption|
|US5405836 *||2 Mar 1993||11 Apr 1995||Nabisco, Inc.||Pet foods with water-soluble zinc compound coating for controlling malodorous breath|
|US7582418||3 Nov 2005||1 Sep 2009||Albion Laboratories, Inc.||Antimicrobial chelates|
|US7687650||29 Dec 2006||30 Mar 2010||Jr Chem, Llc||Chemical compositions and methods of making them|
|US7867522||29 Dec 2006||11 Jan 2011||Jr Chem, Llc||Method of wound/burn healing using copper-zinc compositions|
|US7897800||29 Jan 2007||1 Mar 2011||Jr Chem, Llc||Chemical compositions and methods of making them|
|US7927614||14 Jun 2006||19 Apr 2011||Jr Chem, Llc||Anti-aging treatment using copper and zinc compositions|
|US7939306||12 May 2008||10 May 2011||Colgate-Palmolive Company||Antibacterial dentifrice exhibiting antiplaque and breath freshening properties|
|US8148563||19 Feb 2010||3 Apr 2012||Jr Chem, Llc||Chemical compositions and methods of making them|
|US8273791||10 Dec 2008||25 Sep 2012||Jr Chem, Llc||Compositions, kits and regimens for the treatment of skin, especially décolletage|
|US8505730||23 Aug 2012||13 Aug 2013||Jr Chem, Llc||Compositions, kits and regimens for the treatment of skin, especially décolletage|
|US8952057||16 Jun 2011||10 Feb 2015||Jr Chem, Llc||Compositions for anorectal use and methods for treating anorectal disorders|
|US9427397||8 Feb 2012||30 Aug 2016||Obagi Medical Products, Inc.||Rosacea treatments and kits for performing them|
|US9498421||7 Nov 2013||22 Nov 2016||Colgate-Palmolive Company||Two component compositions containing tetrabasic zinc-amino acid halide complexes and cysteine|
|US9504858||7 Nov 2013||29 Nov 2016||Colgate-Palmolive Company||Zinc amino acid halide complex with cysteine|
|US9572756||19 Dec 2012||21 Feb 2017||Colgate-Palmolive Company||Teeth whitening methods, visually perceptible signals and compositions therefor|
|US9675823||7 Nov 2013||13 Jun 2017||Colgate-Palmolive Company||Two component compositions containing zinc amino acid halide complexes and cysteine|
|US9750670||7 Nov 2013||5 Sep 2017||Colgate-Palmolive Company||Zinc amino acid complex with cysteine|
|US9757316||19 Dec 2012||12 Sep 2017||Colgate-Palmolive Company||Zinc-lysine complex|
|US9763865||19 Dec 2012||19 Sep 2017||Colgate-Palmolive Company||Oral gel comprising zinc-amino acid complex|
|US9775792||19 Dec 2012||3 Oct 2017||Colgate-Palmolive Company||Oral care products comprising a tetrabasic zinc-amino acid-halide complex|
|US20070293466 *||3 Nov 2005||20 Dec 2007||Thompson Robert C||Antimicrobial Chelates|
|US20080152601 *||5 Mar 2008||26 Jun 2008||Colgate-Palmolive Company||Dual Component Dental Composition Containing Enzyme|
|US20080213195 *||12 May 2008||4 Sep 2008||Szeles Lori H||Antibacterial Dentifrice Exhibiting Antiplaque and Breath Freshening Properties|
|US20100266514 *||5 Mar 2008||21 Oct 2010||Colgate-Palmolive Company||Dual Component Dental Composition Containing Enzyme|
|USRE33465 *||4 Apr 1986||27 Nov 1990||Method for reducing the duration of the common cold|
|EP0075446A2 *||16 Sep 1982||30 Mar 1983||Johnson & Johnson Products Inc.||Anticaries composition|
|EP0075446A3 *||16 Sep 1982||11 Jul 1984||Johnson & Johnson Products Inc.||Anticaries composition|
|EP2172187A1||26 Aug 2003||7 Apr 2010||Colgate-Palmolive Company||Dual component dental composition containing enzyme|
|WO1997040812A1 *||24 Apr 1997||6 Nov 1997||Warner-Lambert Company||Enhanced zinc containing oral composition|
|WO2014193251A1||10 Jun 2013||4 Dec 2014||Warszawski Uniwersytet Medyczny||Preparation for maintenance of oral cavity hygiene and prevention of plaque formation|
|U.S. Classification||424/50, 514/696, 424/58, 424/642, 424/52|
|International Classification||A61K8/21, A61K8/30, A61K8/33, A61K8/96, A61K8/19, A61K8/27, A61K8/66, A61Q11/00, A61K8/97|
|Cooperative Classification||A61K8/97, A61K8/66, A61Q11/00, A61K8/27, A61K8/21, A61K8/33|
|European Classification||A61Q11/00, A61K8/21, A61K8/66, A61K8/97, A61K8/33, A61K8/27|