US2410110A - Method of making tablets - Google Patents
Method of making tablets Download PDFInfo
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- US2410110A US2410110A US472416A US47241643A US2410110A US 2410110 A US2410110 A US 2410110A US 472416 A US472416 A US 472416A US 47241643 A US47241643 A US 47241643A US 2410110 A US2410110 A US 2410110A
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- tablets
- tablet
- coating
- vitamin
- beadlets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
Definitions
- This invention relates to compressed tablets and to the method of making the same. More particularly, this invention relates to compressed tablets having a protective coating of substantially uniform thickness and to the method of making the same.
- Compressed pharmaceutical tablets made by tablet-compressing machines are characterizedby straight sides and edges and are Of'the' geometrical form of a short cylinder, the ends of which are curved (convex)
- a coating pan which consisted of a vessel of circular cross-section and a continuously curved contour.
- Successive applications of sugar syrup, sometimes with fillers, such as chalk, kaolin, etc. were made while the tablets were being tumbled therein, dry air being blown over them. This procedure resulted in building up a continuous coating of sugar on the surface of the tablets.
- each tablet formed a finished product whose exterior surface approximated an ellipse, even though the tablet originally and before coating had edges and straight walls. However, the coating was not of uniform thickness. The coating on the cylindrical straight wall of the compressed tablet was filled out and considerably thicker than the coating on the curved ends.
- Sugar coatings are useful for many purposes but are objectionable in certain instances as, for example, when the tablet contents are in part liquid. In such cases, the liquid ingredient might seep through the heterogeneous crystalline sugar coating whereby the exterior surface of the product would be stained and also have imparted thereto an odor. Sugar coatings are also brittle and quite permeable to oxygen, with the result that they do not afiord the protection which is necessary in many instances. In many kinds of tablets, it is desirable to have a better degree of protection than is aiforded by sugar coatings. This is especially true in the case of poly-vitamin tablets wherein at least some of the vitamins are extraordinarily sensitive to oxygen, light, etc.
- An object of this invention is a compressed tablet in the form of a continuously curved geometric solid, such as an oblate sphercid or ellipsoid of revolution, and provided with a coating ofsubstantially uniform thickness.
- Anotherobject of this invention is a compressed tablet in the form of'a continuously curved geometric solid, such as, for example, an oblate spheroid or ellipsoid of revolution, and containing a plurality of vitamins wherein at least some of the vitamins are extraordinarily sensitive to oxygen, light, etc., and provided with a protective coating of substantially uniform thickness.
- a further object of this invention is a method of producing compressed tablets in the form of continuously curved geometric solids, such as, for
- Example, oblate spheroid or ellipsoids of revolu- An additional further object of this invention is a method of treating compressed tablets whereby a protective coating of substantially uniform thickness can be applied thereto, and applying such protective coating.
- Figure 1 is an enlarged elevation of a tablet (partially broken away) made by a tablet-compressing machine
- Figure 2 is an enlarged elevation of a compressed tablet (partially broken away) resulting from the treatment of the tablet shown in Figure 1 in accordance with this invention.
- Figure 3 is an enlarged elevation of the finished coated tablet (partially broken away) made in accordance with this invention.
- the ingredients constituting the tablets are compressed in a tablet-forming machine to produce compressed tablets characterized by straight sides or edges and of a geometric form of a short cylinder, the ends of which are either curved (convex) or fiat.
- the compressed tablets are then tumbled for a protracted period of time in a tumbling barrel or rotating vessel analogous to a tablet-coating pan but without any coating substance therein.
- the continuous tumbling causes the tablets to abrade one another, wearing away the surface at. the edges more rapidly and more deeply than the curved areas. In this way, the tablets are self-abraded.
- the size and weight of the original compressed tablet will be reduced by the self-abrasion, but allowance is made for this in calculating the formula and size of tablet coming from the tablet-compressing machine so that the finalabraded ellipsoid will be of the desired size and contain the ingredients in suflicient amount to provide the desired dosage.
- the dust resulting from the abrasion is returned to the next batch of composition which is to be compressed so that no net loss, or in any case very little loss of the valuable ingredients, may be incurred.
- the ellipsoids may be coated with the appropriate solution orcomposition, as desired. Since the tablets have no straight sides or edges, the coating thereon will be continuous and of substantially uniform thickness.
- the tablet contains a plurality of vitamins and minerals.
- the tablet contains a plurality of vitamins and minerals.
- ents are homogeneously mixed together in the 1 produce a solution in which the concentration of the colloid is such that, upon cooling, the colloid will set to form a firm jelly.
- the abraded poly-vitamin-mineraltablets will be at least in part water-soluble. If a hot aqueone solution of the selected colloid is applied directly to the abraded tablets, the superficial solid ingredients thereof which are soluble will dissolve and diffuse to some extent into the colloid.
- the abraded ellipsoids are first given a thin coating of an edible resin, such as shellac or the like, prior to the application of the protective coating.
- the abraded ellipsoids are tumbled in an alcoholic solution of the resin in a coating pan of the usual type, and thereafter air is blown thereover until the resin coating is thoroughly dried. The resincoated smooth ellipsoids are then given the protective coating of colloid.
- shellac isemployed as the undercoating and gelatin as the colloid coating, though it will be obvious to a person skilled in the art that other substances may be used.
- Any edible substance of suitable solubility characteristics which can be applied in a medium which does not deleteriously affect the ingredients of the tablet and which is not deleteriously affected by water may be used to produce the undercoat.
- Any edible colloidal substance which can be dissolved in water and which can be set, as, for example, by dry-' ing. cooling, etc., and which will substantially resist the penetration of oxygen may be used.
- both of the coatings must also be of a nature so that they can be either assimilated or permit the ingredients of the tablet to be assimilated in the human system when taken orally.
- Iron lrrn 1ammonium citrate brown (U. 75
- a fat solvent such as light 15 petroleum
- the vitamins compatible with vitamin A may be incorporated in the same beadlets.
- the matrices of the beadlets may be formed of agar, pectin, methyl cellulose, etc.
- the granulation of all the other ingredients, except the vitamin A beadlets, the iron beadlets and vitamin C, is prepared, after which the vitamin A beadlets, the iron beadlets and the granules of vitamin C are substantially homo: geneously distributed throughout the granulation.
- the granulation is compressed into tablets, so as shown in Figure 1 and wherein the reference numeral I discloses the tablet as it comes from the tablet-making machine.
- the tablet I has the geometric form of a small cylinder in which the cylindrical wall 2 is straight and the ends 3 are convex.
- a plurality of the compressed tablets are introduced into a tumbling pan, preferably consisting of a vessel of circular cross-section and having a continuously curved contour similar to the construction of the usual sugar-coating pans.
- the tablets I aretumbled in the pan and caused to abrade each other.
- the tumbling, and hence the abrasion, is continued until the edges 4 and the cylindrical walls 2 are rounded off and 1 the tablets approximate ellipsoids in shape.
- Dissolve 24 grainsoi gelatin and 36 grams 0 as, for example, shown in Figure 2 and designated generally by the reference character 5.
- the dust resulting from the abrasion is then removed in any convenient manner, and the resulting tablets, which are now in the shape of ellipsoids, are coated with an alcohol solution of shellac to provide the undercoat 6.
- the shellac undercoating B is preferably applied in a tumbling pan of the usual type. After drying, the shellaccoated tablets are coated with gelatin to provide the protective coating 1.
- the gelatin coating 1 is continuous and of substantially uniform thickness around the tablet.
- the shellac coating 6 intermediate the tablet 5 and the protective gelatin coating 1 is continuous and of substantially uniform thickness.
- the final coated tablet due to the substantially uniform coatings, has a continuously curved surface and is of a geometric form which is substantially ellipsoidal.
- the high speed production of tablet-compressing machines can be utilized in the production of tablets having a continuous protective coating of substantially uniform thickness.
- the tablets contain liquid ingredients, nevertheless such ingredients are incorporated in the form of beadlets to produce a substantially dry product and-to isolate the incompatible ingredients from each other.
- the tablet is formed of a multivitamin-mineral granulation, it is to be understood that the invention is not restricted thereto but is applicable to any tablet having a straight side and edges and which is to be coated. Likewise, the invention is not restricted to a plurality of coatings. If the nature of the tablet permits, an appropriate protective or flavoring coating may be applied directly thereto.
- a method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade one another and continuing the tumbling until the tablets have acquired shapes approximating ellipsoids.
- a method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade one another, said tablets being formed of a granulation containing a plurality of vitamins and minerals and wherein the incompatible ingredients are isolated from each other by being separately incorporated in different beadlets having matrices of a gelable colloid, and continuing the tumbling until the tablets have acquired shapes approximating ellipsoids.
- a method which comprises tumbling compressed tablets having edges and a straight side .to cause said tablets to abrade one another, said tablets being formed of a granulation containing beadlets of a gelable colloid having-vitamin A incorporated therein and beadlets of a gelable colloid having a mineral which is incompatible with vitamin A or any other ingredient in the granulation incorporated therein, and continuing the tumbling until the tablets have acquired shapes approximating ellipsoids.
- a method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade oneanother, said tablets being formed of a granulation containing gelatin beadlets having vitamin A incorporated therein and gelatin beadlets having a mineral which is incompatible with vitamin A or any other ingredient in the granulation incorporated therein, and continuing the tumbling until the tablets have acquired shapes approximating ellipsoids.
- a method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade one another, said tablets being formed of a granulation containing a plurality of vitamins and minerals and wherein the incompatible ingredients are isolated from each other by being separately incorporated in different gelatin beadlets, continuing the tumbling until the tablets have acquired shapes approximating ellipsoids, applying a coating of an I edible resin to said ellipsoids, and applying a protective coating of a colloidal substance which substantially resists the penetration of oxygen on said resin coating.
- a method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade one another, said tablets being formed of a granulation containing gelatin beadlets having vitamin A incorporated therein and gelatin beadlets having a mineral which is incompatible with vitamin A or any other ingredient in the granulation incorporated therein, continuing the tumbling until the tablets have acquired shapes approximating ellipsoids, applying a coating of shellac to said ellipsoids from a solution which does not affect the tablet, and thereafter applying a gelatin coating on said shellac coating.
Description
Oct. 29, 1946.
METHOD OF MAKING TABLETS Filed Jan. 14, 1943 Patented Oct. 29, 1946 METHOD OF MAKING TABLETS Harden F. Taylor, New York, N. Y., assignor, by v mesne assignments, to Brewer & Company, Inc, Worcester, Mass, a corporation of Massachusetts Application January 14, 1943, Serial No. 472,416
7 Claims.
This invention relates to compressed tablets and to the method of making the same. More particularly, this invention relates to compressed tablets having a protective coating of substantially uniform thickness and to the method of making the same.
Compressed pharmaceutical tablets made by tablet-compressing machines are characterizedby straight sides and edges and are Of'the' geometrical form of a short cylinder, the ends of which are curved (convex) In the prior art, it has been customary to coat compressed pharmaceutical tablets by tumbling them in a coating pan, which consisted of a vessel of circular cross-section and a continuously curved contour. Successive applications of sugar syrup, sometimes with fillers, such as chalk, kaolin, etc., were made while the tablets were being tumbled therein, dry air being blown over them. This procedure resulted in building up a continuous coating of sugar on the surface of the tablets. The sugar coating built up around each tablet formed a finished product whose exterior surface approximated an ellipse, even though the tablet originally and before coating had edges and straight walls. However, the coating was not of uniform thickness. The coating on the cylindrical straight wall of the compressed tablet was filled out and considerably thicker than the coating on the curved ends. a
Sugar coatings are useful for many purposes but are objectionable in certain instances as, for example, when the tablet contents are in part liquid. In such cases, the liquid ingredient might seep through the heterogeneous crystalline sugar coating whereby the exterior surface of the product would be stained and also have imparted thereto an odor. Sugar coatings are also brittle and quite permeable to oxygen, with the result that they do not afiord the protection which is necessary in many instances. In many kinds of tablets, it is desirable to have a better degree of protection than is aiforded by sugar coatings. This is especially true in the case of poly-vitamin tablets wherein at least some of the vitamins are extraordinarily sensitive to oxygen, light, etc.
An object of this invention is a compressed tablet in the form of a continuously curved geometric solid, such as an oblate sphercid or ellipsoid of revolution, and provided with a coating ofsubstantially uniform thickness.
Anotherobject of this invention is a compressed tablet in the form of'a continuously curved geometric solid, such as, for example, an oblate spheroid or ellipsoid of revolution, and containing a plurality of vitamins wherein at least some of the vitamins are extraordinarily sensitive to oxygen, light, etc., and provided with a protective coating of substantially uniform thickness.
A further object of this invention is a method of producing compressed tablets in the form of continuously curved geometric solids, such as, for
Example, oblate spheroid or ellipsoids of revolu- An additional further object of this invention is a method of treating compressed tablets whereby a protective coating of substantially uniform thickness can be applied thereto, and applying such protective coating.
. Other objects will become apparent from the following description, appended claims, and accompanying drawing wherein:
Figure 1 is an enlarged elevation of a tablet (partially broken away) made by a tablet-compressing machine;
Figure 2 is an enlarged elevation of a compressed tablet (partially broken away) resulting from the treatment of the tablet shown in Figure 1 in accordance with this invention; and
Figure 3 is an enlarged elevation of the finished coated tablet (partially broken away) made in accordance with this invention. I
In accordance with the principles of this invention, the ingredients constituting the tablets are compressed in a tablet-forming machine to produce compressed tablets characterized by straight sides or edges and of a geometric form of a short cylinder, the ends of which are either curved (convex) or fiat. The compressed tablets are then tumbled for a protracted period of time in a tumbling barrel or rotating vessel analogous to a tablet-coating pan but without any coating substance therein. The continuous tumbling causes the tablets to abrade one another, wearing away the surface at. the edges more rapidly and more deeply than the curved areas. In this way, the tablets are self-abraded. This self-abrasion of the tablets is continued until the tablets have assumed a shape which is the resultant of the original shape and the efiective abrasion, i. e. tablets having a continuously curved exterior surface, such as, for example, an ellipsoid.
'The size and weight of the original compressed tablet will be reduced by the self-abrasion, but allowance is made for this in calculating the formula and size of tablet coming from the tablet-compressing machine so that the finalabraded ellipsoid will be of the desired size and contain the ingredients in suflicient amount to provide the desired dosage. The dust resulting from the abrasion is returned to the next batch of composition which is to be compressed so that no net loss, or in any case very little loss of the valuable ingredients, may be incurred.
When the abrasion dust has been removed in any appropriate manner, the ellipsoids may be coated with the appropriate solution orcomposition, as desired. Since the tablets have no straight sides or edges, the coating thereon will be continuous and of substantially uniform thickness.
In one form of the invention, the tablet contains a plurality of vitamins and minerals. In this embodiment of the .invention,
ents are homogeneously mixed together in the 1 produce a solution in which the concentration of the colloid is such that, upon cooling, the colloid will set to form a firm jelly.
The abraded poly-vitamin-mineraltablets will be at least in part water-soluble. If a hot aqueone solution of the selected colloid is applied directly to the abraded tablets, the superficial solid ingredients thereof which are soluble will dissolve and diffuse to some extent into the colloid. In order to avoid this effect, the abraded ellipsoids are first given a thin coating of an edible resin, such as shellac or the like, prior to the application of the protective coating. Preferably, the abraded ellipsoids are tumbled in an alcoholic solution of the resin in a coating pan of the usual type, and thereafter air is blown thereover until the resin coating is thoroughly dried. The resincoated smooth ellipsoids are then given the protective coating of colloid.
In the preferred embodiment of this invention, shellac isemployed as the undercoating and gelatin as the colloid coating, though it will be obvious to a person skilled in the art that other substances may be used. Any edible substance of suitable solubility characteristics which can be applied in a medium which does not deleteriously affect the ingredients of the tablet and which is not deleteriously affected by water may be used to produce the undercoat. Any edible colloidal substance which can be dissolved in water and which can be set, as, for example, by dry-' ing. cooling, etc., and which will substantially resist the penetration of oxygen may be used. Obviously, both of the coatings must also be of a nature so that they can be either assimilated or permit the ingredients of the tablet to be assimilated in the human system when taken orally.
Hereinafter, there is set forth a specific illustrative preferred example of the invention which, it is to be understood, is in no wise limitative thereof:
EXAMPLE Quantity Ingredient Material per 3,000
tablets Grams Vitamin A Fish liver oil concentrate, 200,000 20 units vitamin A per 2mm. V tam n B1 Crystalline thiamin chloride 0. 696 Vitamin G Crystalline riboflavin l. 85 Vitamin P-P Crystalline niacinamide 9.13 V tamin C Crystalline ascorbic acid 30. 0 Vitamin D Viosterol in oil, 400,000 units per .1.0
gram. 0 a l c ium a n d, Calcium pyrophosphate 820.
phosphorous. Iron lrrn 1ammonium citrate brown (U. 75
the ingredi- I hereafter more fully Preparation of vitamin '4 beadlets. v
corn syrup in 50 gramsof water. Best to 65' C. and emulsify grams of vitamin A concentrate in the hot solution. .Form the emulsion into beadlets according to my United States Patent No. 2,183,053, or United States'Patent No. 2,183,- 084. Or, alternatively, pour the hot emulsion onto the cold surface, such as plate glass, cool, chill, strip 01!, dry, and grind to'40 mesh fineness. In the case of granulation made by grinding the dried sheet, wash with a fat solvent, such as light 15 petroleum, to remove vitamin A concentrate exposed in the grinding, and evaporate traces of residual solvent. The result will be a fine vitamin A powder.
Preparation 0 the iron ammonium citrate beadlets The following ingredients, in the proportions set forth, are formed into beadlets as hereafter described:
Gelatin rams..- 1'15 Corn syrup do 250 Water cc 400 Iron ammonium citrate brown,
U. S. P grams '75 Dissolve the iron ammonium citrate in 400 cc. of water, and thereafter dissolve therein 250 grams of corn syrup, stirring well. Add to this solution 175 grains of the U. S. P.'gelatin. Allow to soak overnight, then heat to 65 C. to a viscous solution. Form this into beadlets as above described. The iron compound and the vitamin A would be'incompatible in intimate contact, since the 40 iron would constitute a catalyst for the oxidation oi vitamin A.
' Also, the same incompatibility applies to iron and vitamin C or ascorbic acid. These incompatibilities have been overcome by the imprisonment of vitamin A in one batch of gelatin granules or beadlets, and the iron in another batch, while the vitamin, C being a dry granulation powder' is also isolated from the iron.
If desired, all the vitamins compatible with vitamin A may be incorporated in the same beadlets. Also, the matrices of the beadlets may be formed of agar, pectin, methyl cellulose, etc. The granulation of all the other ingredients, except the vitamin A beadlets, the iron beadlets and vitamin C, is prepared, after which the vitamin A beadlets, the iron beadlets and the granules of vitamin C are substantially homo: geneously distributed throughout the granulation. The granulation is compressed into tablets, so as shown in Figure 1 and wherein the reference numeral I discloses the tablet as it comes from the tablet-making machine. As is apparent from Figure 1, the tablet I has the geometric form of a small cylinder in which the cylindrical wall 2 is straight and the ends 3 are convex.
A plurality of the compressed tablets are introduced into a tumbling pan, preferably consisting of a vessel of circular cross-section and having a continuously curved contour similar to the construction of the usual sugar-coating pans. The tablets I aretumbled in the pan and caused to abrade each other. The tumbling, and hence the abrasion, is continued until the edges 4 and the cylindrical walls 2 are rounded off and 1 the tablets approximate ellipsoids in shape. such Dissolve 24 grainsoi gelatin and 36 grams 0 as, for example, shown in Figure 2 and designated generally by the reference character 5.
The dust resulting from the abrasion is then removed in any convenient manner, and the resulting tablets, which are now in the shape of ellipsoids, are coated with an alcohol solution of shellac to provide the undercoat 6. The shellac undercoating B is preferably applied in a tumbling pan of the usual type. After drying, the shellaccoated tablets are coated with gelatin to provide the protective coating 1. The gelatin coating 1 is continuous and of substantially uniform thickness around the tablet. Likewise, also, the shellac coating 6 intermediate the tablet 5 and the protective gelatin coating 1 is continuous and of substantially uniform thickness.
The final coated tablet, due to the substantially uniform coatings, has a continuously curved surface and is of a geometric form which is substantially ellipsoidal. By virtue of the herein described process, the high speed production of tablet-compressing machines can be utilized in the production of tablets having a continuous protective coating of substantially uniform thickness. Though the tablets contain liquid ingredients, nevertheless such ingredients are incorporated in the form of beadlets to produce a substantially dry product and-to isolate the incompatible ingredients from each other.
Though in the specific illustrative preferred embodiment the tablet is formed of a multivitamin-mineral granulation, it is to be understood that the invention is not restricted thereto but is applicable to any tablet having a straight side and edges and which is to be coated. Likewise, the invention is not restricted to a plurality of coatings. If the nature of the tablet permits, an appropriate protective or flavoring coating may be applied directly thereto.
Since it is obvious that various changes and modifications may be made in the above description without departing from the nature or spirit thereof, this invention is not restricted thereto except as set forth in the appended claims.
I claim:
1. A method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade one another and continuing the tumbling until the tablets have acquired shapes approximating ellipsoids.
2. A method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade one another, said tablets being formed of a granulation containing a plurality of vitamins and minerals and wherein the incompatible ingredients are isolated from each other by being separately incorporated in different beadlets having matrices of a gelable colloid, and continuing the tumbling until the tablets have acquired shapes approximating ellipsoids.
3. A method which comprises tumbling compressed tablets having edges and a straight side .to cause said tablets to abrade one another, said tablets being formed of a granulation containing beadlets of a gelable colloid having-vitamin A incorporated therein and beadlets of a gelable colloid having a mineral which is incompatible with vitamin A or any other ingredient in the granulation incorporated therein, and continuing the tumbling until the tablets have acquired shapes approximating ellipsoids.
4. -A method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade one another, said tablets being formedof a granulation containing a plurality of vitamins and minerals and wherein the incompatible ingredients are isolated from each other by being separately incorporated in different gelatin beadlets, and continuing the tumbling until the tablets have acquired shapes approximating ellipsoids.
5. A method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade oneanother, said tablets being formed of a granulation containing gelatin beadlets having vitamin A incorporated therein and gelatin beadlets having a mineral which is incompatible with vitamin A or any other ingredient in the granulation incorporated therein, and continuing the tumbling until the tablets have acquired shapes approximating ellipsoids.
6. A method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade one another, said tablets being formed of a granulation containing a plurality of vitamins and minerals and wherein the incompatible ingredients are isolated from each other by being separately incorporated in different gelatin beadlets, continuing the tumbling until the tablets have acquired shapes approximating ellipsoids, applying a coating of an I edible resin to said ellipsoids, and applying a protective coating of a colloidal substance which substantially resists the penetration of oxygen on said resin coating.
7. A method which comprises tumbling compressed tablets having edges and a straight side to cause said tablets to abrade one another, said tablets being formed of a granulation containing gelatin beadlets having vitamin A incorporated therein and gelatin beadlets having a mineral which is incompatible with vitamin A or any other ingredient in the granulation incorporated therein, continuing the tumbling until the tablets have acquired shapes approximating ellipsoids, applying a coating of shellac to said ellipsoids from a solution which does not affect the tablet, and thereafter applying a gelatin coating on said shellac coating.
HARDEN F. TAYLOR.
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Cited By (36)
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US2481412A (en) * | 1945-03-26 | 1949-09-06 | Wisconsin Alumni Res Found | Inactivated compounds of antianemia metals |
US2481413A (en) * | 1945-04-17 | 1949-09-06 | Wisconsin Alumni Res Found | Colloidal compounds containing metallic ions in inactive state |
US2517513A (en) * | 1943-02-27 | 1950-08-01 | Vaernet Carl | Pharmaceutical preparation for implantation |
US2553806A (en) * | 1950-07-12 | 1951-05-22 | Parke Davis & Co | Enteric composition and method of making same |
US2553544A (en) * | 1947-06-02 | 1951-05-22 | Parke Davis & Co | Enteric vitamin preparations |
US2555463A (en) * | 1949-03-28 | 1951-06-05 | Parke Davis & Co | Stabilized sodium pantothenate composition |
US2562840A (en) * | 1948-04-27 | 1951-07-31 | Lilly Co Eli | Vitamin preparations |
US2650895A (en) * | 1947-02-24 | 1953-09-01 | Mead Johnson & Co | Spray dried vitamin a and d emulsion |
US2674960A (en) * | 1949-05-04 | 1954-04-13 | Pasquale Patrick J De | Method of producing frozen comestibles |
US2676136A (en) * | 1951-01-02 | 1954-04-20 | Collett Week Corp | Process of producing solid fatsoluble vitamin pellets |
US2687367A (en) * | 1952-05-05 | 1954-08-24 | Lilly Co Eli | Medicinal tablet containing identification fragments |
US2689202A (en) * | 1951-12-11 | 1954-09-14 | Pfizer & Co C | Process of grinding frozen vitamin a material |
US2701782A (en) * | 1951-05-11 | 1955-02-08 | Upjohn Co | Method of making and aqueous suspension of methyl cellulose |
US2702262A (en) * | 1952-04-28 | 1955-02-15 | Pfizer & Co C | Vitamin composition |
US2712507A (en) * | 1953-06-30 | 1955-07-05 | Ncr Co | Pressure sensitive record material |
US2730457A (en) * | 1953-06-30 | 1956-01-10 | Ncr Co | Pressure responsive record materials |
US2730456A (en) * | 1953-06-30 | 1956-01-10 | Ncr Co | Manifold record material |
US2756177A (en) * | 1953-03-09 | 1956-07-24 | Hoffmann La Roche | Process for making fat-soluble vitamin active powder |
US2768115A (en) * | 1951-11-02 | 1956-10-23 | Bristol Lab Inc | Penicillin-aspirin tablets |
US2800458A (en) * | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
US2800457A (en) * | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
US2955982A (en) * | 1951-01-22 | 1960-10-11 | Parmelee Pharmaceutical Compan | Continuous process for internally reinforcing salt tablets |
US3125491A (en) * | 1962-04-06 | 1964-03-17 | Chew able hematinic vitamin tablet | |
US3473490A (en) * | 1966-01-17 | 1969-10-21 | Camillo Corvi Mora | Producing chronoactive pharmaceutical granules |
US3627695A (en) * | 1969-05-05 | 1971-12-14 | Ncr Co | Insolubilization of gelatin-containing film by citrate treatment |
US4353887A (en) * | 1979-08-16 | 1982-10-12 | Ciba-Geigy Corporation | Divisible tablet having controlled and delayed release of the active substance |
WO1987006128A1 (en) * | 1986-04-07 | 1987-10-22 | Clemetson Ab Charles | Catechin coated ascorbic acid and method |
EP0279682A2 (en) * | 1987-02-20 | 1988-08-24 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
EP0319318A2 (en) * | 1987-12-04 | 1989-06-07 | McNEIL-PPC, INC. | Method for double dipping gelatin coated caplets |
US4965089A (en) * | 1989-04-10 | 1990-10-23 | Sauter Manufacturing Corp. | Method and apparatus for the gelatin coating of caplets |
EP0401389A1 (en) * | 1988-12-28 | 1990-12-12 | Taisho Pharmaceutical Co. Ltd | Stress scattering method in tableting |
EP0435726A2 (en) * | 1989-12-29 | 1991-07-03 | Bristol-Myers Squibb Company | Capsule and caplet combination |
US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
US20030223653A1 (en) * | 2002-05-28 | 2003-12-04 | Knoerzer Anthony Robert | Package with pocket and method for making the same |
US20080008801A1 (en) * | 2004-10-22 | 2008-01-10 | Symrise Gmbh & Co. Kg | Pressed Agglomerates Suitable for Consumption |
US20130228945A1 (en) * | 2007-06-13 | 2013-09-05 | Peter B. Franklin | Method and assembly for manufacturing ingestible products |
-
1943
- 1943-01-14 US US472416A patent/US2410110A/en not_active Expired - Lifetime
Cited By (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2517513A (en) * | 1943-02-27 | 1950-08-01 | Vaernet Carl | Pharmaceutical preparation for implantation |
US2481412A (en) * | 1945-03-26 | 1949-09-06 | Wisconsin Alumni Res Found | Inactivated compounds of antianemia metals |
US2481413A (en) * | 1945-04-17 | 1949-09-06 | Wisconsin Alumni Res Found | Colloidal compounds containing metallic ions in inactive state |
US2650895A (en) * | 1947-02-24 | 1953-09-01 | Mead Johnson & Co | Spray dried vitamin a and d emulsion |
US2553544A (en) * | 1947-06-02 | 1951-05-22 | Parke Davis & Co | Enteric vitamin preparations |
US2562840A (en) * | 1948-04-27 | 1951-07-31 | Lilly Co Eli | Vitamin preparations |
US2555463A (en) * | 1949-03-28 | 1951-06-05 | Parke Davis & Co | Stabilized sodium pantothenate composition |
US2674960A (en) * | 1949-05-04 | 1954-04-13 | Pasquale Patrick J De | Method of producing frozen comestibles |
US2553806A (en) * | 1950-07-12 | 1951-05-22 | Parke Davis & Co | Enteric composition and method of making same |
US2676136A (en) * | 1951-01-02 | 1954-04-20 | Collett Week Corp | Process of producing solid fatsoluble vitamin pellets |
US2955982A (en) * | 1951-01-22 | 1960-10-11 | Parmelee Pharmaceutical Compan | Continuous process for internally reinforcing salt tablets |
US2701782A (en) * | 1951-05-11 | 1955-02-08 | Upjohn Co | Method of making and aqueous suspension of methyl cellulose |
US2768115A (en) * | 1951-11-02 | 1956-10-23 | Bristol Lab Inc | Penicillin-aspirin tablets |
US2689202A (en) * | 1951-12-11 | 1954-09-14 | Pfizer & Co C | Process of grinding frozen vitamin a material |
US2702262A (en) * | 1952-04-28 | 1955-02-15 | Pfizer & Co C | Vitamin composition |
US2687367A (en) * | 1952-05-05 | 1954-08-24 | Lilly Co Eli | Medicinal tablet containing identification fragments |
US2756177A (en) * | 1953-03-09 | 1956-07-24 | Hoffmann La Roche | Process for making fat-soluble vitamin active powder |
US2730456A (en) * | 1953-06-30 | 1956-01-10 | Ncr Co | Manifold record material |
US2730457A (en) * | 1953-06-30 | 1956-01-10 | Ncr Co | Pressure responsive record materials |
US2800458A (en) * | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
US2800457A (en) * | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
US2712507A (en) * | 1953-06-30 | 1955-07-05 | Ncr Co | Pressure sensitive record material |
US3125491A (en) * | 1962-04-06 | 1964-03-17 | Chew able hematinic vitamin tablet | |
US3473490A (en) * | 1966-01-17 | 1969-10-21 | Camillo Corvi Mora | Producing chronoactive pharmaceutical granules |
US3627695A (en) * | 1969-05-05 | 1971-12-14 | Ncr Co | Insolubilization of gelatin-containing film by citrate treatment |
US4353887A (en) * | 1979-08-16 | 1982-10-12 | Ciba-Geigy Corporation | Divisible tablet having controlled and delayed release of the active substance |
WO1987006128A1 (en) * | 1986-04-07 | 1987-10-22 | Clemetson Ab Charles | Catechin coated ascorbic acid and method |
EP0279682A2 (en) * | 1987-02-20 | 1988-08-24 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
GR880100096A (en) * | 1987-02-20 | 1988-12-16 | Mcneilab Inc | Coated caps and process for the production therefor |
EP0279682A3 (en) * | 1987-02-20 | 1989-10-18 | Mcneilab, Inc. | Gelatin coated caplets and process for making same |
EP0319318A2 (en) * | 1987-12-04 | 1989-06-07 | McNEIL-PPC, INC. | Method for double dipping gelatin coated caplets |
EP0319318A3 (en) * | 1987-12-04 | 1989-10-18 | Mcneil Consumer Products Company | Method for double dipping gelatin coated caplets |
GR1000299B (en) * | 1987-12-04 | 1992-05-12 | Mcneil Consumer Prod | Method for double imbibing of capsules covered with celluloid |
EP0401389A1 (en) * | 1988-12-28 | 1990-12-12 | Taisho Pharmaceutical Co. Ltd | Stress scattering method in tableting |
EP0401389A4 (en) * | 1988-12-28 | 1991-07-03 | Taisho Pharmaceutical Co. Ltd | Stress scattering method in tableting |
US4965089A (en) * | 1989-04-10 | 1990-10-23 | Sauter Manufacturing Corp. | Method and apparatus for the gelatin coating of caplets |
EP0435726A2 (en) * | 1989-12-29 | 1991-07-03 | Bristol-Myers Squibb Company | Capsule and caplet combination |
EP0435726A3 (en) * | 1989-12-29 | 1991-08-14 | Bristol-Myers Squibb Company | Capsule and caplet combination |
US5314696A (en) * | 1991-06-27 | 1994-05-24 | Paulos Manley A | Methods for making and administering a blinded oral dosage form and blinded oral dosage form therefor |
US5558878A (en) * | 1991-06-27 | 1996-09-24 | Captab, L.L.C. | Method for blinding a tableted medication |
US5576019A (en) * | 1991-06-27 | 1996-11-19 | Captab 11C | Method for blinding a medication |
US20030223653A1 (en) * | 2002-05-28 | 2003-12-04 | Knoerzer Anthony Robert | Package with pocket and method for making the same |
US20080008801A1 (en) * | 2004-10-22 | 2008-01-10 | Symrise Gmbh & Co. Kg | Pressed Agglomerates Suitable for Consumption |
US20130228945A1 (en) * | 2007-06-13 | 2013-09-05 | Peter B. Franklin | Method and assembly for manufacturing ingestible products |
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