US2323582A - Method and apparatus for capsulating liquids - Google Patents
Method and apparatus for capsulating liquids Download PDFInfo
- Publication number
- US2323582A US2323582A US393293A US39329341A US2323582A US 2323582 A US2323582 A US 2323582A US 393293 A US393293 A US 393293A US 39329341 A US39329341 A US 39329341A US 2323582 A US2323582 A US 2323582A
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- US
- United States
- Prior art keywords
- strips
- liquid
- rolls
- portions
- gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000007788 liquid Substances 0.000 title description 32
- 238000000034 method Methods 0.000 title description 10
- 239000002775 capsule Substances 0.000 description 29
- 108010010803 Gelatin Proteins 0.000 description 20
- 229920000159 gelatin Polymers 0.000 description 20
- 239000008273 gelatin Substances 0.000 description 20
- 235000019322 gelatine Nutrition 0.000 description 20
- 235000011852 gelatine desserts Nutrition 0.000 description 20
- 230000002093 peripheral effect Effects 0.000 description 6
- 239000007903 gelatin capsule Substances 0.000 description 5
- 238000010276 construction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 230000000875 corresponding effect Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S264/00—Plastic and nonmetallic article shaping or treating: processes
- Y10S264/37—Processes and molds for making capsules
Definitions
- the invention relates to a method and ⁇ apparatus for capsulating liquids and more particularly to that type in whichthe capsules are formed from separate strips oil gelatin.
- the capsules are formed from separate strips oil gelatin.
- such separate gelatin strips have been first pressed together along their marginal edge p0rtions to form a tubular section into which the medicament or other liquid content is fed, and this lled tubular portion is then passed between die rolls which fashion and separate the individual capsules.
- the latter operation includes:
- gelatin strips are of suilicient width to form transverse rows of capsules, and
- gelatin strips are not always of exactly the same thickness, and if the combined thickness of the two strips is less than the clearance provided by the rolls, they will not be -pressed together intermediate the capsules.
- a further objection to this method is that it is sometimes desirable to use gelatin strips of changing the capsule forming dies.
- the invention consists in the method and apparatus as hereinafter set forth.
- Fig. 1 is a vertical longitudinal section through a portion of a capsule forming machine to which my improvements are applied and which is capable of carrying out my improved method;
- Fig. 2 is a plan view
- Fig, 3 is an end elevation
- Fig. 4 is an enlarged view similar to a portion of Fig. 1;
- Fig. 5 is an enlarged section showingin i'ull and dotted lines capsules having the same external dimensions but dverent amounts of iluid content.
- a and A are the cooperating die rolls for formingthe capsules.
- the specific construction of the apparatus for supplying the gelatin strips to4 these die rolls is not a part of the instant application and may therefore be only generally described as follows:
- the separate gelatin strips B and B may be formed by any suitable means which is adjustable to vary the thickness of these strips within predetermined limits.
- the strlpsthus formed are then fed over rollers C and C which seal the opposite marginal edge portions together to form a tubular portion Bl which is then fed vertically different thicknesses, for reasons 4that will be downward to the rolls A, A.
- a tube D feeds 4the liquid to be capsuiated into the portion Bite roll to come into rolling contactwith the corre-- sponding ilange in the registering pocket.
- the pockets E are further provided with lugs G projecting outward from the inner ends thereof and forming stops which limit the external diameterv of the capsule.
- Air passages G' extend centrally through the lugs G and are connected at certain times to suction means, the arrangement being such that the portions of the gelatin strips which contact with the annular flanges F will be drawn inward when suction is applied, to form a half capsule.
- this will seal the passage G', cutting oi the suction and preventing further expansion, after which the rotation of the rolls A, A will bring the flanges F into contact to seal the liquid-filled half capsule sections to each other and to sever the same from the remainder of the strips.
- peripheral surfaces H of the rolls A and A' between the pocket-surrounding annular flanges F are of smaller radius so as to leave spaces therebetween at the point of closest approach between the rolls, viz., in the common axial plane thereof.
- This space is of greater radial depth than that of gelatin iilms of maximum thickness, so that instead of pressing the strips together at such point, there will be left a liquid-lled space,
- the anges'F when brought into contact, will seal together the immediately adJacent portions of the strips, both inside and outside said flanges, and will also sever these ⁇ portions from each other.
- the capsules When the pockets E separate from each other on the lower sides of said rolls, the capsules will be retained in one or the other of said pockets and may be subsequently expelled therefrom by positive air pressure entering through the passages G'.
- the liquid-filled net B3 passes vertically downward between the rolls and then horizontally over a tank I. This may be accomplished by passing the net around a roller J which may be driven by suitable means such as the belt J', at a peripheral speed substantially equal to that of the net.
- the horizontal portion is supported on a series of rollers K, K', etc., which also are driven, at substantially the same peripheral speed, by means of pulleys L on one end of each roll, and a driving belt L'.
- This belt also passes around idler pulleys L2 between adjacent pulleys L, but at a lower level, thereby giving sufiicient wrap about the pulleys to insure proper driving of the same.
- a tightener pulley L3 is placed at any convenient point to maintain proper tension on the belt.
- almeans for puncturing the Walls thereof so as to permit the liquid to drain into the tank I comprises a roller ⁇ M provided with a multiplicity of sharp radially projecting points M' and cooperating with a pocketed roller K2. the net being fed between'these rollers.
- a pair of wringer or squeezing rollers N and K3 which engage the net after it passes the rollers M and K2 and force out all of the remaining liquid, The net is then passed around a roller K4 at the end of the tank and into a suitable receptacle O therebeneath.
- Fig, 5 illustrates in full lines a capsule Q formed of strips of one thickness and having a predetermined liquid content; also, in dotted lines, a capsule Q' having the same external dimensions but smaller in capacity for liquid content, due to the increased thickness of the gelatin strip. It will thus be understood that it is not necessary to provide as many different sizes of die rolls as have been required in the past, for, by changing the thickness of the strips, the same dies will give capsules of different capacities.
- a pair of die rolls having registering pockets therein arranged in transverse and circumferential series, means for feeding a pair of marginally sealed spaced and liquid-nlled gelatin strips downward between said rolls, annular portions surrounding each ofthe pockets in the respective rolls adapted to roll in contact with each other, the peripheral portions of said rolls intermediate said annular portions being spaced from each other at the point of closest approach by a dimension greater than that of the combined thickness of the gelatin strips, means for expanding the portions of said strips registering with said pockets to form liquid-filled capsule portions which are sealed together and severed from the remainder of said strips by said contacting annular portions, thereby leaving a liquid-filled net formed by the remainder of said strips, ,means for puncturing said net during the continued advancement of the same, and means for squeezing out and recovering the liquid content from said punctured net.
- a pair of die rolls having registering pockets therein, arranged in transverse and circumferential series, means for feeding a pair of marginally sealed spaced and liquid-filled gelatin strips downward between said rolls, annular portions surrounding each of the pockets in the respective rolls adapted to roll in contact with each other, the peripheral portions of said rolls intermediate said annular portions being spaced from each other at the point of closest approach by a dimension greater than that oi the combined thickness of the gelatin strips, means for expanding the portions of said strips registering with said pockets to form liquid-nlled capsule portions which are sealed together and severed from the remainder of said strips by said contacting annular portions, thereby leaving a liquid-illled net formed by the remainder of said strips, means for advancing said net over a liquid-collecting receptacle, means for puncturing.
- a pair of die rolls having registering pockets therein arranged in transverse and circumferential series, means for feeding a pair of marginally sealed spaced and liquid-filled gelatin strips between said rolls, annular portions surrounding each of the pockets in the respective rolls adapted to roll in contact with each other,
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Description
July 6, 1943. c. L wEcKEssx-:R
vMETHOD AND APPARATUS FOR CAPSULATING LIQUIDS Filed May 15, 1941 2 Sheets-Sheet l 1. lll '|114 IN VEN TOR R S no, WM w. Lm l- Rw A H C July 6, 1943. c. L. wl-:cKEssER METHOD AND APPARATUS FOR CAPSULATING LIQUIDS Filed, May 1s, 1941 l2 sheets-sheet 2 INVENTOR HARLES LNEGKESSER BY A wm ATTORNE S iilfl'l'l'i Patented July 6, 1943 METHOD AND APPARATUS FOR CAPSULATING LIQUIDS Charles L. Weckesscr, Detroit, Mich., assignor to C. E. Jamieson & Co., Detroit, Mich., a corporation i Michigan Application May A13, 1941,sei-ia1No. 393,293
5 Claims. (C
i content in the capsules may be varied without The invention relates to a method and` apparatus for capsulating liquids and more particularly to that type in whichthe capsules are formed from separate strips oil gelatin. Heretofore, such separate gelatin strips have been first pressed together along their marginal edge p0rtions to form a tubular section into which the medicament or other liquid content is fed, and this lled tubular portion is then passed between die rolls which fashion and separate the individual capsules. The latter operation includes:
First, forming half capsules by sucking portions of the strip into pockets in the rolls;
Second, pressing the margins of these half capsules together to form a sealing of the same; and
Third, severing th completed capsules from the remainder of the strips.
Usually the gelatin strips are of suilicient width to form transverse rows of capsules, and
all of the capsules in each row are simultaneously formed. The portions of the strip intermediate the capsules are fed bptweenthe die rolls, which therefore must provide suicient clearance for this purpose. Howeverfif the clearance is not greater than the thickness of the two strips, the latter will be pressed together so as to force all liquid from between the same into the tubular portion thereabove.
One difficulty experienced in connection with the method and apparatus above described is that the gelatin strips are not always of exactly the same thickness, and if the combined thickness of the two strips is less than the clearance provided by the rolls, they will not be -pressed together intermediate the capsules.
A further objection to this method is that it is sometimes desirable to use gelatin strips of changing the capsule forming dies.
With these objects in view, the invention consists in the method and apparatus as hereinafter set forth. l y
In the drawings: y
Fig. 1 is a vertical longitudinal section through a portion of a capsule forming machine to which my improvements are applied and which is capable of carrying out my improved method;
Fig. 2 is a plan view;
Fig, 3 is an end elevation; y
Fig. 4 is an enlarged view similar to a portion of Fig. 1; and
Fig. 5 is an enlarged section showingin i'ull and dotted lines capsules having the same external dimensions but diilerent amounts of iluid content.
As illustrated in Fig. 1, A and A are the cooperating die rolls for formingthe capsules. The specific construction of the apparatus for supplying the gelatin strips to4 these die rolls is not a part of the instant application and may therefore be only generally described as follows:
The separate gelatin strips B and B may be formed by any suitable means which is adjustable to vary the thickness of these strips within predetermined limits. The strlpsthus formed are then fed over rollers C and C which seal the opposite marginal edge portions together to form a tubular portion Bl which is then fed vertically different thicknesses, for reasons 4that will be downward to the rolls A, A. A tube D feeds 4the liquid to be capsuiated into the portion Bite roll to come into rolling contactwith the corre-- sponding ilange in the registering pocket. The pockets E are further provided with lugs G projecting outward from the inner ends thereof and forming stops which limit the external diameterv of the capsule. Air passages G' extend centrally through the lugs G and are connected at certain times to suction means, the arrangement being such that the portions of the gelatin strips which contact with the annular flanges F will be drawn inward when suction is applied, to form a half capsule. When the gelatin contacts with the lug G, this will seal the passage G', cutting oi the suction and preventing further expansion, after which the rotation of the rolls A, A will bring the flanges F into contact to seal the liquid-filled half capsule sections to each other and to sever the same from the remainder of the strips. The construction and operation as above described has heretofore been used and is not a part of the instant invention.
The peripheral surfaces H of the rolls A and A' between the pocket-surrounding annular flanges F are of smaller radius so as to leave spaces therebetween at the point of closest approach between the rolls, viz., in the common axial plane thereof. This space is of greater radial depth than that of gelatin iilms of maximum thickness, so that instead of pressing the strips together at such point, there will be left a liquid-lled space, The anges'F, when brought into contact, will seal together the immediately adJacent portions of the strips, both inside and outside said flanges, and will also sever these `portions from each other. As a result, the portions of the strips intermediate the capsule portions will form a hollow net B3 which, as well as the capsule portions, will be lled with the liquid. As this would be very wasteful of the medicament or other liquid, I have provided the following means for recovering the same:
When the pockets E separate from each other on the lower sides of said rolls, the capsules will be retained in one or the other of said pockets and may be subsequently expelled therefrom by positive air pressure entering through the passages G'. The liquid-filled net B3 passes vertically downward between the rolls and then horizontally over a tank I. This may be accomplished by passing the net around a roller J which may be driven by suitable means such as the belt J', at a peripheral speed substantially equal to that of the net. The horizontal portion is supported on a series of rollers K, K', etc., which also are driven, at substantially the same peripheral speed, by means of pulleys L on one end of each roll, and a driving belt L'. This belt also passes around idler pulleys L2 between adjacent pulleys L, but at a lower level, thereby giving sufiicient wrap about the pulleys to insure proper driving of the same. A tightener pulley L3 is placed at any convenient point to maintain proper tension on the belt.
At one point in the travel of the horizontal portion B4 of the net, there is arranged almeans for puncturing the Walls thereof so as to permit the liquid to drain into the tank I. This, as shown, comprises a roller` M provided with a multiplicity of sharp radially projecting points M' and cooperating with a pocketed roller K2. the net being fed between'these rollers. There is also provided a pair of wringer or squeezing rollers N and K3 which engage the net after it passes the rollers M and K2 and force out all of the remaining liquid, The net is then passed around a roller K4 at the end of the tank and into a suitable receptacle O therebeneath. Thus, all of the liquid which was held by the net is recovered in the tank I and may be returned therefrom to the source of supply. The rollers K, K', etc., M and N are mounted on a suitable supporting frame P, and the tank I is also supported on this frame. As the tank extends the full length of the horizontal portion of the net, it will catch any liquid that might escape through an imperfect seal between the strips, as Well as that which is positively forced out after the puncturing of the net.
The pockets E in the die rollers A and A', together with the lugs G, determine the outside dimension of the capsule, but the amount of liquid filler in each capsule depends upon the thickness of the gelatin strips. Thus, where it is desired to vary the amount of content, this may be accomplished by changing the thickness of the strips. Fig, 5 illustrates in full lines a capsule Q formed of strips of one thickness and having a predetermined liquid content; also, in dotted lines, a capsule Q' having the same external dimensions but smaller in capacity for liquid content, due to the increased thickness of the gelatin strip. It will thus be understood that it is not necessary to provide as many different sizes of die rolls as have been required in the past, for, by changing the thickness of the strips, the same dies will give capsules of different capacities.
What I claim as my invention is:
1. In an apparatus for forming liquid-filled gelatin capsules, a pair of die rolls having registering pockets therein arranged in transverse and circumferential series, means for feeding a pair of marginally sealed spaced and liquid-nlled gelatin strips downward between said rolls, annular portions surrounding each ofthe pockets in the respective rolls adapted to roll in contact with each other, the peripheral portions of said rolls intermediate said annular portions being spaced from each other at the point of closest approach by a dimension greater than that of the combined thickness of the gelatin strips, means for expanding the portions of said strips registering with said pockets to form liquid-filled capsule portions which are sealed together and severed from the remainder of said strips by said contacting annular portions, thereby leaving a liquid-filled net formed by the remainder of said strips, ,means for puncturing said net during the continued advancement of the same, and means for squeezing out and recovering the liquid content from said punctured net.
2. In an apparatus for forming `liquid-filled gelatin capsules, a pair of die rolls having registering pockets therein, arranged in transverse and circumferential series, means for feeding a pair of marginally sealed spaced and liquid-filled gelatin strips downward between said rolls, annular portions surrounding each of the pockets in the respective rolls adapted to roll in contact with each other, the peripheral portions of said rolls intermediate said annular portions being spaced from each other at the point of closest approach by a dimension greater than that oi the combined thickness of the gelatin strips, means for expanding the portions of said strips registering with said pockets to form liquid-nlled capsule portions which are sealed together and severed from the remainder of said strips by said contacting annular portions, thereby leaving a liquid-illled net formed by the remainder of said strips, means for advancing said net over a liquid-collecting receptacle, means for puncturing.
said net, and squeeze rolls for forcing a liquid from said punctured net into said receptacle.
3. In a process of forming liquid-filled gelatin capsules of variable content but with the same external dimensions, the steps of expanding at one time into a die pocket of predetermined dimensions a gelatin strip of a selected thickness to obtain a predetermined volume within the inner surface of the` expanded portion of the` strip and at another time'expanding into said die pocket a strip of a different selected thickness to obtain a different volume within said inner surface of the expanded portion.
4. In a process of forming liquid-filled gelatin capsules of variable content but with the same external dimensions, the steps comprising utilizing a die pocket of predetermined dimensions and in expanding into said pocket gelatin strips of varying thicknesses to correspondingly vary the content of the capsules.
5. In an apparatus for forming liquid-filled gelatin capsules, a pair of die rolls having registering pockets therein arranged in transverse and circumferential series, means for feeding a pair of marginally sealed spaced and liquid-filled gelatin strips between said rolls, annular portions surrounding each of the pockets in the respective rolls adapted to roll in contact with each other,
vthe peripheral portions of said rolls intermediate said annular portions being spaced from each other at the point of closest approach by a dimension greater than that of the combined thickness of the gelatin strips, means for expanding the portions of said strips registering with said pockets to form liquid-filled capsule portions which are sealed together and severed from the remainder of said strips by said contacting annular portions, thereby leaving a liquid-filled net formed by theremainder of said strips and means for recovering the liquid content from the net.
CHARLES L. WECKESSER.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US393293A US2323582A (en) | 1941-05-13 | 1941-05-13 | Method and apparatus for capsulating liquids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US393293A US2323582A (en) | 1941-05-13 | 1941-05-13 | Method and apparatus for capsulating liquids |
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US2323582A true US2323582A (en) | 1943-07-06 |
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US393293A Expired - Lifetime US2323582A (en) | 1941-05-13 | 1941-05-13 | Method and apparatus for capsulating liquids |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2449139A (en) * | 1944-07-08 | 1948-09-14 | John Kennedy Power | Apparatus for manufacturing and filling capsules |
US2624163A (en) * | 1948-04-22 | 1953-01-06 | American Cyanamid Co | Method of making colored gelatin capsules |
US2848854A (en) * | 1952-10-02 | 1958-08-26 | Pickering Dorothy Frances | Process for the production of containers filled with liquids or pastes from a pliable non-metallic material of thermoplastic nature |
US2878630A (en) * | 1954-12-13 | 1959-03-24 | American Cyanamid Co | Machine for stripping capsules |
US2936493A (en) * | 1955-06-16 | 1960-05-17 | Scherer Corp R P | Method of making plastic capsules |
US4447373A (en) * | 1982-02-16 | 1984-05-08 | The Procter & Gamble Company | Process for making filled articles from polymeric material |
-
1941
- 1941-05-13 US US393293A patent/US2323582A/en not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2449139A (en) * | 1944-07-08 | 1948-09-14 | John Kennedy Power | Apparatus for manufacturing and filling capsules |
US2624163A (en) * | 1948-04-22 | 1953-01-06 | American Cyanamid Co | Method of making colored gelatin capsules |
US2848854A (en) * | 1952-10-02 | 1958-08-26 | Pickering Dorothy Frances | Process for the production of containers filled with liquids or pastes from a pliable non-metallic material of thermoplastic nature |
US2878630A (en) * | 1954-12-13 | 1959-03-24 | American Cyanamid Co | Machine for stripping capsules |
US2936493A (en) * | 1955-06-16 | 1960-05-17 | Scherer Corp R P | Method of making plastic capsules |
US4447373A (en) * | 1982-02-16 | 1984-05-08 | The Procter & Gamble Company | Process for making filled articles from polymeric material |
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