US2193322A - Controllable transfer element for multiple compartment ampules - Google Patents
Controllable transfer element for multiple compartment ampules Download PDFInfo
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- US2193322A US2193322A US205170A US20517038A US2193322A US 2193322 A US2193322 A US 2193322A US 205170 A US205170 A US 205170A US 20517038 A US20517038 A US 20517038A US 2193322 A US2193322 A US 2193322A
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- Prior art keywords
- ampule
- transfer element
- disc
- compartment
- syringe
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2448—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2459—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/329—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
- A61M5/3291—Shafts with additional lateral openings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
- A61M5/344—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub using additional parts, e.g. clamping rings or collets
Definitions
- An object of our invention is an ampule havlh ing multiple separate compartments containing dissimilar ingredients.
- Another object is an improved controllable transfer element having a piercing body provided with a channel and designed to establish comga munication between the compartments in the ampule, said transfer element being provided with means to prevent escape of the mixed fluids through the outer end of the channel and the hypodermic needle of the syringe during transas ference, but permitting discharge through the needle after transference.
- a further object is an improved syringe in combination with the multiple compartment ampule and the controllable transfer element as which is designed to discharge the injection solution from the ampule after transfer.
- all three stoppers are positioned entirely inside and frictionally slidable in the ampule. It is neces- 45 sary to move the intermediate disc during the operation of the expulsion of the mixed liquids into the patient's tissues and to lubrlcatethe outer peripheries of the discs in order to facilitate the movement of all the discs.
- Fig. 1 shows a longitudinal cross sectional view of our multiple compartment ampule having three discs in predetermined spaced relatio therein.
- Fig. 2 is an enlarged fragmentary view of one modification of our transfer element and multiple compartment ampule in transferred posi-tion.
- Fig. 3 is thesame in discharge position.
- Fig. 4 is an enlarged fragmentary view of another modification of our transferred element and ampule in transfer position.
- Fig. 1 shows the ampule with the discs positioned therein in spaced relation so as to form the compartments 4 and 5 which may'contain dissimilar liquids.
- the compartments 4 and '5 are hermetically sealed from each other by the disc 3a due to its frictional sealing engagement in the tubular member 2.
- the disc 3 is positioned at or near one end. 3 of the tubular member- 2, and that the disc 30 is spaced at a predetermined distance therefrom to form the compartment 4, while the disc 3b has been positioned inwardly from the end I of the tubular member 2 so as to form the closed compartment '5.
- This position of the disc 3b between' the end 1 and stopper 3a is governed by the length of the compartment 5.
- the length of the open end-space is substantially the same as the length of the compartment 4.
- the end space is essential, to permit the movement of the disc 3b when the liquid in compartment 4 is transferred into compartment 5
- all the discs are positioned entirely inside the casing 2.
- the end discs 3 and 31) have their outer peripheries lubricated and are frictionally slidable in the casing tube.
- Fig. 1 shows the ampule l with the three discs of the same diameter throughout their length in the positions they occupy before the liquid in compartment 4 has been transferred into compartment 5.
- Fig. 2 shows I the same arrangement during transfer and indicates so much of the body of the syringe to which the transfer element is attached as is necessary to explain the operation of the transfer.
- the syringe consists of a barrel 3, a solid head 9 with a threaded portion l0, and the knurled nut l2, and collar H.
- the plunger head and the plunger of the syringe are not shown. They may be of any design customary in this art.
- 21 is a hypodermic needle provided with a a sharply beveled outer end 28, a sharply beveled inner end 29, and a soft metal collar 30 near the latter.
- I3 is the controllable transfer element. It is mounted in the syringe head S'slidably along its longltudinal'axis, and consists substantially ofa hollow tube 4. It is surrounded by the concentric sleeve 22. Its inner end is sharply beveled, while the outer end 2
- the transfer element is controlled in its longitudinal movements in either direction by the stops I 5 and I5 positioned in the cavity 23 which is surrounded'by the concentric sleeve 22. Rigidly attached to the tube I4 is a collar 23a, located within the cavity 23. Ports '24 and 25, which open intothe channel 26, complete the structure of the concentric sleeve 22.
- Fig. 2 also shows the hypodermic needle 21 mounted in the syringe 3 and combined with the amass:
- a 3 faces the sharply beveled inner end 23 of the transfer element l3.
- Continued motion in the same direction causes the inner end 23 to suecessively pierce discs 3 and 3a and then presses disc 3 against collar 1! which forces the disc inwardly of the ampule l in the direction of the stationary disc 30.
- the stoppers 3 and 3a are now in contacting position; when the compartments 4 and 5 contain liquids, due to the incompressibllity of the liquids, the liquid in compartment 4will be transferred to the compartment 5 by way of port Isa and through the channel of the hollow tube l4.
- both end discs 3 and 3b are movable simultaneously and equally, while disc 3a remains fixed during liquid transference.
- the disc 35 will move to the end I of the ampule
- outer motion is imposed on the readily slidable transfer element l3 by the resistance of disc 3 to penetration of the inner end 23, which causes the plug and ports to register as shown in Fig. 2.
- This outer motion causes the plug H to register with port 24 in the concentric sleeve 22, thereby closing the port and preventing the escape of the liquid, contained in the ampule, through the outer end 2
- Fig. 3 shows the operation of the transfer element as a conductor of the liquid from the ampule to the hypodermic needle during discharge.
- the knurled nut I2 is turned inwardly whereby the needle 21 and its collar 30 are advanced, the latter developing pressure on the outer end 2
- the ports l8 and I3 are new registered with the plug between the ports 24 and 25 of the concentric sleeve 22, thereby forming a continuous open passage from the interior of the ampule through end 20 to the hypodermic needle 21.
- Figs. 4 and 5 demonstrate another modification of the transfer element.
- the parts of the syringe and ampule and the numerals designating those parts are the same as in Figs. 1, 2 and 3.
- is the controllable transfer element. It is mounted in the syringe head 3 slidably along its longitudinal axis and consists substantially of a hollow tube 32. Its inner end 33 is sharply beveled, while the outer end 34 is squarely cut. Near its inner end, the element 3
- the transfer element is controlled in its movements in either direction by stops '38 and 33 and collar 33a which is rigidly attached to the tube 32 and slidably positioned in the cavity 40 of the syringe head 3.
- Fig. 5 shows the operation of the transfer element as a conductor of the liquid from the ampule to the hypodermic needle during discharge.
- Inward motion of the transfer element for the purpose of ejection of the liquid from the ampule to the hypodermic needle is accomplished by the inward movement of the needle nut l2 against the metal collar 30 on the hypodermic 'needle 21 on the square end 34 of the transfer element 3
- This inward movement causes both ports 36 and 31 of the transfer element to register within the cavity of the disc 3, thereby forming an open passage from the ampule to the hypodermic needle.
- prevents further outer movement of the collar 39a in the cavity 40 beyond the stop 38 when our device is in transfer position as shown in Fig. 4.
- may be lifted away from the cavity 40, thus enabling removal from or the insertion into the syringe head 9 of the transfer element 3
- a transfer and discharge system for transferring the contents of one compartment to the other and discharging the mixed contents through the hypodermic needle, which system comprises a syringe head provided with an annular protrusion facing inwardly of the syringe barrel, a central bore penetrating the entire length of said head and protrusion, a hollow tube slidably mounted in said bore and sharply beveled at its end extending ahead of said protrusion but squarely cut at its other end extending through the head, a collar rigidly attached to the tube, a cavity in said head slidably embracing said collar and controlling its movements, said hollow tube being partitioned by a plug and being provided with a plurality of lateral ports, said plug and said ports so registering with said cavity and said end disc of the ampule facing said annular protrusion as to close passage of the liquid
- a of ports and channels comprises a plug posi-
Description
March 12, 1940. POZIER H 2,192,322
CONTROLLABLE TRANSFER ELEMENT FOR MULTIPLE COMPARTMENT AMPULES Filed April 30. 1938 69d /77: l z ga 4 4/ 8 4/ A3 8 39 /3 F A 84 w THEIR ATTOR EYS Patented Mar. 12, 1940 UNITED STATES, PATENT OFFICE CONTBOLLABI I 'E TRANSFER ELEMENT FOB MULTIPLE COMPAB'FMENT AMPULES Matthew Lozier, Brooklyn, N. 'Y., and Clayton Herbert Frost, Newark, N. J., assignors to Cook Laboratories, Inc., New York, N, Y., a corporation of Delaware Application April 30, 1938, Serial No. 205,170
3 Claims.
which are customarily employed for hypodermic injections.
More particularly we are concerned with 5 ampules having separate compartments which contain dissimilar ingredients to be mixed into a desired injection solution. We contemplate solutions which are not stable in prolonged storage and which must therefore be prepared by the practitioner shortly before use through intermingling of the necessary ingredients contained in the separate compartments in a convenient sterile manner. 7
An object of our invention is an ampule havlh ing multiple separate compartments containing dissimilar ingredients.
Another object is an improved controllable transfer element having a piercing body provided with a channel and designed to establish comga munication between the compartments in the ampule, said transfer element being provided with means to prevent escape of the mixed fluids through the outer end of the channel and the hypodermic needle of the syringe during transas ference, but permitting discharge through the needle after transference.
A further object is an improved syringe in combination with the multiple compartment ampule and the controllable transfer element as which is designed to discharge the injection solution from the ampule after transfer.
Further objects will be seen from the following description.
In our earliest disclosure Ser. No. 124,010, now
as matured into Patent No. 2,115,731, dated May 3, 1938, we define two separate compartments in the ampule by three spaced discs of piercea'ble material, the outer discs closing the opposite open ends of the ampule, and the intermediate.
40 disc being spaced from the outer discs in accordance with the desired size of the two compartments. For the purpose of the invention, all three stoppers are positioned entirely inside and frictionally slidable in the ampule. It is neces- 45 sary to move the intermediate disc during the operation of the expulsion of the mixed liquids into the patient's tissues and to lubrlcatethe outer peripheries of the discs in order to facilitate the movement of all the discs.
This lubrication together with the ever present possibility of expansion and contraction of the glass container, due to variation in temperature as well as to the slight variation in the internal diameter of the container, presents a possibility as of seepage around the intermediate disc from (01,.128-215) Our invention relates to syringes and ampulesv one compartment to the other, which is detrimental'to the use of the ampule, since it is essen-' tial to maintain the two dissimilar liquids in hermetic separation until the moment of intermixture of theliquids by the aid of a transfer element.
To prevent the possibility of seepage, we provide in our application Ser. No. 172,892,'now
matured into Patent No. 2,159,217, dated May 23, 1939, a new method of expulsion of the liquid 1 contents of the ampule which does not require the movement of the intermediate disc and makes it unnecessary, therefore, to lubricate the outer periphery of said disc, whereby the disc remains practically immovable.
We describe the transfer element in our Patent No. 2,115,731 which moves the intermediate disc as being secured to the plunger of the syringe and consisting of a hollow piercing element having a sharp and tapering end portion and an axially positioned channel adapted to communicate with an aperture in the side of combined liquid from the ampule directly,
through a hypodermic needle into the tissue without removing the ampule from the syringe,
and without seepage.
We have now designed further improved controllable transfer elements which are simpler in construction and much safer in operation than the transfer element in application Ser. No. 1'72, 892. v
Reference is made to the accompanying sheet of drawings which illustrates the new transfer elements, and their operative combination with the syringe and. multiple compartment ampule.
Fig. 1 shows a longitudinal cross sectional view of our multiple compartment ampule having three discs in predetermined spaced relatio therein.
Fig. 2 is an enlarged fragmentary view of one modification of our transfer element and multiple compartment ampule in transferred posi-tion.
Fig. 3 is thesame in discharge position.
Fig. 4 is an enlarged fragmentary view of another modification of our transferred element and ampule in transfer position.
diameter of the 'member 2 inv sealing relation.
Fig. 1 shows the ampule with the discs positioned therein in spaced relation so as to form the compartments 4 and 5 which may'contain dissimilar liquids. The compartments 4 and '5 are hermetically sealed from each other by the disc 3a due to its frictional sealing engagement in the tubular member 2. .It will be noted that in Fig. 1, the disc 3 is positioned at or near one end. 3 of the tubular member- 2, and that the disc 30 is spaced at a predetermined distance therefrom to form the compartment 4, while the disc 3b has been positioned inwardly from the end I of the tubular member 2 so as to form the closed compartment '5. This position of the disc 3b between' the end 1 and stopper 3a is governed by the length of the compartment 5. The length of the open end-space is substantially the same as the length of the compartment 4. The end space is essential, to permit the movement of the disc 3b when the liquid in compartment 4 is transferred into compartment 5 For the purpose of our invention, all the discs are positioned entirely inside the casing 2. The end discs 3 and 31) have their outer peripheries lubricated and are frictionally slidable in the casing tube.
Fig. 1 shows the ampule l with the three discs of the same diameter throughout their length in the positions they occupy before the liquid in compartment 4 has been transferred into compartment 5.
Fig. 2 shows I the same arrangement during transfer and indicates so much of the body of the syringe to which the transfer element is attached as is necessary to explain the operation of the transfer.
The syringe consists of a barrel 3, a solid head 9 with a threaded portion l0, and the knurled nut l2, and collar H. The plunger head and the plunger of the syringe are not shown. They may be of any design customary in this art.
21 is a hypodermic needle provided with a a sharply beveled outer end 28, a sharply beveled inner end 29, and a soft metal collar 30 near the latter.
I3 is the controllable transfer element. It is mounted in the syringe head S'slidably along its longltudinal'axis, and consists substantially ofa hollow tube 4. It is surrounded by the concentric sleeve 22. Its inner end is sharply beveled, while the outer end 2| is cut off squarely. Near the outer end 2| there is provided a plug l1 and'ports l8 and I9 at the end of plug II in the wall of tube l4. Close to the sharply beveled inner end 20 there is out out from the tube a lateral inlet at Isa. The transfer element is controlled in its longitudinal movements in either direction by the stops I 5 and I5 positioned in the cavity 23 which is surrounded'by the concentric sleeve 22. Rigidly attached to the tube I4 is a collar 23a, located within the cavity 23. Ports '24 and 25, which open intothe channel 26, complete the structure of the concentric sleeve 22.
Fig. 2 also shows the hypodermic needle 21 mounted in the syringe 3 and combined with the amass:
A 3 faces the sharply beveled inner end 23 of the transfer element l3. Continued motion in the same direction causes the inner end 23 to suecessively pierce discs 3 and 3a and then presses disc 3 against collar 1! which forces the disc inwardly of the ampule l in the direction of the stationary disc 30. The stoppers 3 and 3a are now in contacting position; when the compartments 4 and 5 contain liquids, due to the incompressibllity of the liquids, the liquid in compartment 4will be transferred to the compartment 5 by way of port Isa and through the channel of the hollow tube l4. By this action it is to be noted that both end discs 3 and 3b are movable simultaneously and equally, while disc 3a remains fixed during liquid transference. The disc 35 will move to the end I of the ampule At the same time, outer motion is imposed on the readily slidable transfer element l3 by the resistance of disc 3 to penetration of the inner end 23, which causes the plug and ports to register as shown in Fig. 2. This outer motion causes the plug H to register with port 24 in the concentric sleeve 22, thereby closing the port and preventing the escape of the liquid, contained in the ampule, through the outer end 2| of the transfer element, and the hypodermic needle 21, as the channel 26 in the sleeve 22 is blocked by the plug I].
Fig. 3 shows the operation of the transfer element as a conductor of the liquid from the ampule to the hypodermic needle during discharge. Proceeding from the arrangement shown in Fig. 2, the knurled nut I2 is turned inwardly whereby the needle 21 and its collar 30 are advanced, the latter developing pressure on the outer end 2| of the transfer element l3 and moving it inward, until it comes to a halt when the collar 23a has reached its extreme inward position in the cavity 23. The ports l8 and I3 are new registered with the plug between the ports 24 and 25 of the concentric sleeve 22, thereby forming a continuous open passage from the interior of the ampule through end 20 to the hypodermic needle 21. At the same time, the joint between the metal collar on the hypodermic needle 21 and the outer end 2| of the'transfer element I3 is now sealed and prevents leakage flowing through the transfer element into the hypodermic needle. during ejection of the contents of the multiple ampule contained in the syringe.
Figs. 4 and 5 demonstrate another modification of the transfer element. The parts of the syringe and ampule and the numerals designating those parts are the same as in Figs. 1, 2 and 3.
3| is the controllable transfer element. It is mounted in the syringe head 3 slidably along its longitudinal axis and consists substantially of a hollow tube 32. Its inner end 33 is sharply beveled, while the outer end 34 is squarely cut. Near its inner end, the element 3| is provided with a plug 35 and ports 36 and 31 at the end of plug 35 in the wall of tube 32. The transfer element is controlled in its movements in either direction by stops '38 and 33 and collar 33a which is rigidly attached to the tube 32 and slidably positioned in the cavity 40 of the syringe head 3.
2,193,822 To accomplish transfer of liquid from com- 7 tion is thereby imposed on the transfer element 3| by the'resistance of the disc 3 to penetration by the sharply beveled end 33 which causes the plug 35 and ports 36' and 31 to register as indicated in Fig. 4. Discs 3 and 3a are now in contacting position. Again the liquid which is contained in compartment 4, due to its incompressibility, will be transferred to compartment 5 by Way of port 31 and through the channel of the hollow tube 32, but it cannot escape through the transfer element in the direction of the needle 2'! since passage is closed by the plug 35 now located in the wall of the disc 3. The disc 3b will move simultaneously and equally to the end I of the ampule I.
Fig. 5 shows the operation of the transfer element as a conductor of the liquid from the ampule to the hypodermic needle during discharge. Inward motion of the transfer element for the purpose of ejection of the liquid from the ampule to the hypodermic needle is accomplished by the inward movement of the needle nut l2 against the metal collar 30 on the hypodermic 'needle 21 on the square end 34 of the transfer element 3|. This inward movement causes both ports 36 and 31 of the transfer element to register within the cavity of the disc 3, thereby forming an open passage from the ampule to the hypodermic needle. The springlike attachment 4| prevents further outer movement of the collar 39a in the cavity 40 beyond the stop 38 when our device is in transfer position as shown in Fig. 4. On the other hand,
when the knurled nut I2 is removed from the.
threaded portion In of the syringe head 9, the attachment 4| may be lifted away from the cavity 40, thus enabling removal from or the insertion into the syringe head 9 of the transfer element 3|, theattachment 4| then automatically returning into position as shown in Fig. 4 by virtue of the spring action.
We prefer the transfer element of Figures 4 and 5 because of the simplicity of its construction and the ease of operation. It will be seen that the various parts of the combination can readily be separated for purposes of cleaning and repair and may be assembled just as conveniently.
We claim: 1
1. In combination with a hypodermic syringe and multiple compartment ampule having two chambers formed therein by two movable end discs and a permanently fixed intermediate disc, a transfer and discharge system for transferring the contents of one compartment to the other and discharging the mixed contents through the hypodermic needle, which system comprises a syringe head provided with an annular protrusion facing inwardly of the syringe barrel, a central bore penetrating the entire length of said head and protrusion, a hollow tube slidably mounted in said bore and sharply beveled at its end extending ahead of said protrusion but squarely cut at its other end extending through the head, a collar rigidly attached to the tube, a cavity in said head slidably embracing said collar and controlling its movements, said hollow tube being partitioned by a plug and being provided with a plurality of lateral ports, said plug and said ports so registering with said cavity and said end disc of the ampule facing said annular protrusion as to close passage of the liquid from the ampule to the hypodermic needle in transfer position and to form an open passage from the ampule to the hypodermic needle during discharge position.
2. The transfer and discharge system in accordance with claim 1, in which the plurality tioned near the squarely cut end of the hollow tube, ports at the end of the plug in the walls of said tube, a concentric sleeve surrounding said tube adjacent to said end and provided with a channel having slots registering with said ports in discharge position but registering with the plug in transfer position, and a lateral inlet cut,
.end-disc of the ampule closing passage of the liquid from the ampule-to the hypodermic needle 'in transfer position, and said ports registering with the cavity of said end disc thereby forming an open passage from the ampule to the hypodermic needle during discharge position.
MATTIEW LOZIER. CLAYTON HERBERT FROST.
a of ports and channels comprises a plug posi-
Priority Applications (1)
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US205170A US2193322A (en) | 1938-04-30 | 1938-04-30 | Controllable transfer element for multiple compartment ampules |
Applications Claiming Priority (1)
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US205170A US2193322A (en) | 1938-04-30 | 1938-04-30 | Controllable transfer element for multiple compartment ampules |
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US2193322A true US2193322A (en) | 1940-03-12 |
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Cited By (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2512568A (en) * | 1946-08-13 | 1950-06-20 | Jacob A Saffir | Hypodermic injection device |
US2549417A (en) * | 1949-08-10 | 1951-04-17 | Frederick M Turnbull | Syringe ampoule |
US2567001A (en) * | 1950-02-06 | 1951-09-04 | Thomas E Watson | Hypodermic syringe |
US2584397A (en) * | 1945-10-03 | 1952-02-05 | Louis K Pitman | Apparatus for transferring liquid from one container to another |
US2591046A (en) * | 1948-10-18 | 1952-04-01 | Frederick M Turnbull | Hypodermic syringe assembly |
US2607341A (en) * | 1948-12-24 | 1952-08-19 | Frederick M Turnbull | Hypodermic syringe assembly |
US2646798A (en) * | 1950-09-21 | 1953-07-28 | Frank E Brown | Cartridge syringe |
US2655919A (en) * | 1951-04-17 | 1953-10-20 | Charles B Goodstein | Hypodermic syringe and cartridge therefor |
US2665690A (en) * | 1950-09-29 | 1954-01-12 | Compule Corp | Plural-compartment admixing container or vial |
US2665687A (en) * | 1950-08-02 | 1954-01-12 | Frederick M Turnbull | Syringe assembly |
US2724383A (en) * | 1951-06-28 | 1955-11-22 | Compule Corp | Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations |
DE1085652B (en) * | 1959-02-12 | 1960-07-21 | Gruenenthal Chemie | Cylinder ampoule |
US3108591A (en) * | 1962-05-29 | 1963-10-29 | Bristol Mycrs Company | Syringe |
US3405712A (en) * | 1966-02-07 | 1968-10-15 | Richard L. Pierick | Desiccative syringe |
US3470874A (en) * | 1966-06-24 | 1969-10-07 | Anthony F Accetta | Mixing syringe |
US3735761A (en) * | 1971-02-11 | 1973-05-29 | Ampoules Inc | Hypodermic devices |
FR2172101A1 (en) * | 1972-02-15 | 1973-09-28 | Sherwood Medical Ind Inc | |
US3875012A (en) * | 1974-01-30 | 1975-04-01 | Wadley Res Inst & Blood Bank | Apparatus and method for the detection of microbial pathogens |
US3911916A (en) * | 1971-10-29 | 1975-10-14 | Peter A Stevens | Sequential injection syringe |
US3946732A (en) * | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
US4413991A (en) * | 1982-03-18 | 1983-11-08 | Schmitz John B | Dual dose ampule |
DE3343887A1 (en) * | 1983-12-05 | 1985-06-13 | Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht | ARRANGEMENT FOR PLACING A SEPARATOR BETWEEN TWO PHASES IN A SAMPLE TUBE |
US5133362A (en) * | 1990-12-28 | 1992-07-28 | Gerald Moss | Needle for use with vacuum test tube blood sampling systems |
US5232457A (en) * | 1991-08-05 | 1993-08-03 | Grim John P | Medical syringe |
US5251786A (en) * | 1991-08-16 | 1993-10-12 | Helena Laboratories Corporation | Biological fluid collection and delivery apparatus and method |
US5476449A (en) * | 1992-12-28 | 1995-12-19 | Richmond; Frank M. | Needleless multi-liquid medicament delivery system with membranes |
US8356927B1 (en) | 2011-10-13 | 2013-01-22 | Angioletto Lordi | Universal hand mixer |
US20140170594A1 (en) * | 2012-12-14 | 2014-06-19 | Bryan Larson | Dual medicament carpule for dental syringes |
US20150051582A1 (en) * | 2001-09-12 | 2015-02-19 | Becton, Dickinson And Company | Microneedle-Based Pen Device For Drug Delivery And Method For Using Same |
US9694134B2 (en) | 2013-09-16 | 2017-07-04 | Zoetis Services Llc | Assembly for sequentially delivering substances, and associated methods |
-
1938
- 1938-04-30 US US205170A patent/US2193322A/en not_active Expired - Lifetime
Cited By (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2584397A (en) * | 1945-10-03 | 1952-02-05 | Louis K Pitman | Apparatus for transferring liquid from one container to another |
US2512568A (en) * | 1946-08-13 | 1950-06-20 | Jacob A Saffir | Hypodermic injection device |
US2591046A (en) * | 1948-10-18 | 1952-04-01 | Frederick M Turnbull | Hypodermic syringe assembly |
US2607341A (en) * | 1948-12-24 | 1952-08-19 | Frederick M Turnbull | Hypodermic syringe assembly |
US2549417A (en) * | 1949-08-10 | 1951-04-17 | Frederick M Turnbull | Syringe ampoule |
US2567001A (en) * | 1950-02-06 | 1951-09-04 | Thomas E Watson | Hypodermic syringe |
US2665687A (en) * | 1950-08-02 | 1954-01-12 | Frederick M Turnbull | Syringe assembly |
US2646798A (en) * | 1950-09-21 | 1953-07-28 | Frank E Brown | Cartridge syringe |
US2665690A (en) * | 1950-09-29 | 1954-01-12 | Compule Corp | Plural-compartment admixing container or vial |
US2655919A (en) * | 1951-04-17 | 1953-10-20 | Charles B Goodstein | Hypodermic syringe and cartridge therefor |
US2724383A (en) * | 1951-06-28 | 1955-11-22 | Compule Corp | Combined mixing container structure and hypodermic syringe for segregated ingredients of hypodermically injectable preparations |
DE1085652B (en) * | 1959-02-12 | 1960-07-21 | Gruenenthal Chemie | Cylinder ampoule |
US3108591A (en) * | 1962-05-29 | 1963-10-29 | Bristol Mycrs Company | Syringe |
US3405712A (en) * | 1966-02-07 | 1968-10-15 | Richard L. Pierick | Desiccative syringe |
US3470874A (en) * | 1966-06-24 | 1969-10-07 | Anthony F Accetta | Mixing syringe |
US3735761A (en) * | 1971-02-11 | 1973-05-29 | Ampoules Inc | Hypodermic devices |
US3911916A (en) * | 1971-10-29 | 1975-10-14 | Peter A Stevens | Sequential injection syringe |
FR2172101A1 (en) * | 1972-02-15 | 1973-09-28 | Sherwood Medical Ind Inc | |
US3946732A (en) * | 1973-08-08 | 1976-03-30 | Ampoules, Inc. | Two-chamber mixing syringe |
US3875012A (en) * | 1974-01-30 | 1975-04-01 | Wadley Res Inst & Blood Bank | Apparatus and method for the detection of microbial pathogens |
US4031892A (en) * | 1974-07-18 | 1977-06-28 | Ampoules Corporation | Two-chamber mixing syringe |
US4413991A (en) * | 1982-03-18 | 1983-11-08 | Schmitz John B | Dual dose ampule |
DE3343887A1 (en) * | 1983-12-05 | 1985-06-13 | Walter Sarstedt Kunststoff-Spritzgußwerk, 5223 Nümbrecht | ARRANGEMENT FOR PLACING A SEPARATOR BETWEEN TWO PHASES IN A SAMPLE TUBE |
US5133362A (en) * | 1990-12-28 | 1992-07-28 | Gerald Moss | Needle for use with vacuum test tube blood sampling systems |
US5232457A (en) * | 1991-08-05 | 1993-08-03 | Grim John P | Medical syringe |
US5251786A (en) * | 1991-08-16 | 1993-10-12 | Helena Laboratories Corporation | Biological fluid collection and delivery apparatus and method |
US5476449A (en) * | 1992-12-28 | 1995-12-19 | Richmond; Frank M. | Needleless multi-liquid medicament delivery system with membranes |
US20150051582A1 (en) * | 2001-09-12 | 2015-02-19 | Becton, Dickinson And Company | Microneedle-Based Pen Device For Drug Delivery And Method For Using Same |
US10661066B2 (en) * | 2001-09-12 | 2020-05-26 | Becton, Dickinson And Company | Microneedle-based pen device for drug delivery and method for using same |
US8356927B1 (en) | 2011-10-13 | 2013-01-22 | Angioletto Lordi | Universal hand mixer |
US20140170594A1 (en) * | 2012-12-14 | 2014-06-19 | Bryan Larson | Dual medicament carpule for dental syringes |
US9055992B2 (en) * | 2012-12-14 | 2015-06-16 | Bryan Larson | Dual medicament carpule for dental syringes |
US9694134B2 (en) | 2013-09-16 | 2017-07-04 | Zoetis Services Llc | Assembly for sequentially delivering substances, and associated methods |
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