US20150322596A1 - Composite thread and manufacture process thereof - Google Patents
Composite thread and manufacture process thereof Download PDFInfo
- Publication number
- US20150322596A1 US20150322596A1 US14/490,680 US201414490680A US2015322596A1 US 20150322596 A1 US20150322596 A1 US 20150322596A1 US 201414490680 A US201414490680 A US 201414490680A US 2015322596 A1 US2015322596 A1 US 2015322596A1
- Authority
- US
- United States
- Prior art keywords
- wrapping film
- thread
- film solution
- core thread
- composite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/44—Yarns or threads characterised by the purpose for which they are designed
- D02G3/448—Yarns or threads for use in medical applications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/02—Yarns or threads characterised by the material or by the materials from which they are made
- D02G3/04—Blended or other yarns or threads containing components made from different materials
- D02G3/045—Blended or other yarns or threads containing components made from different materials all components being made from artificial or synthetic material
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/22—Yarns or threads characterised by constructional features, e.g. blending, filament/fibre
- D02G3/36—Cored or coated yarns or threads
-
- D—TEXTILES; PAPER
- D02—YARNS; MECHANICAL FINISHING OF YARNS OR ROPES; WARPING OR BEAMING
- D02G—CRIMPING OR CURLING FIBRES, FILAMENTS, THREADS, OR YARNS; YARNS OR THREADS
- D02G3/00—Yarns or threads, e.g. fancy yarns; Processes or apparatus for the production thereof, not otherwise provided for
- D02G3/44—Yarns or threads characterised by the purpose for which they are designed
- D02G3/449—Yarns or threads with antibacterial properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Textile Engineering (AREA)
- Surgery (AREA)
- Materials Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
Abstract
A composite thread including a core thread and at least one wrapping film is provided. The wrapping film wraps the core thread uniformly. The composite thread is mainly formed by the biodegradable material, and has improved biocompatibility which is suitable to be used in the surgery. A manufacture process thereof is also provided.
Description
- This application claims the priority benefit of Taiwan application serial no. 103116544, filed on May 9, 2014. The entirety of the above-mentioned patent application is hereby incorporated by reference herein and made a part of this specification.
- 1. Field of the Invention
- The invention relates to a thread and a manufacturing process thereof, and particularly relates to a biodegradable composite thread and a manufacturing process thereof.
- 2. Description of Related Art
- Generally speaking, threads are commonly used in surgeries to sew organs such as blood vessels, viscera, and skin, etc. Since the materials and characteristics of threads influence how the threads are treated after surgeries, the development on the materials of threads becomes an important issue. Based on the structures of the materials, the threads may be divided into single-strand threads and multi-strand threads. Based on the sources of the materials, the threads may be divided into natural threads and synthetic threads. In addition, based on the absorbability of the threads, the threads may be divided into absorbable threads and unabsorbable threads.
- The unabsorbable threads are not degradable, so the threads need to be removed after being used. On the contrary, the absorbable threads are degradable. When used to sew a cut, the absorbable threads may be absorbed by the human body after a period of time, and is thus not necessary to be removed. Accordingly, the absorbable threads are nowadays commonly used in surgeries that require sewing. The absorbable threads have a preferable biocompatibility and appropriate tensile strength, which improve the safety as well as convenience in the surgery. Besides, it is preferred that the threads has a preferable surface sliding characteristics, so that after the threads pass through the organs or are knotted, the friction force generated when fixing the tissues is reduced as much as possible.
- The invention provides a composite thread and a manufacturing method thereof. The composite thread has biodegradability and is suitable to be implanted into an organism and capable of generating a specific effect.
- A composite thread of the invention includes a core thread and at least one wrapping film. In addition, the wrapping film wraps a surface of the core thread.
- A manufacturing method of a composite thread of the invention includes manufacturing steps as follows: providing a core thread formed of a plurality of line segments connected in series; continuously immersing the core thread into a first wrapping film solution and removing the core thread from the first wrapping film solution, wherein each of the line segments of the core thread is removed from the first wrapping film solution after the next line segment is immersed into the first wrapping film solution; obtaining the core thread wrapped by a first wrapping film by performing a first drying step; continuously immersing the core thread wrapped by the first wrapping film into a second wrapping film solution and removing the core thread wrapped by the first wrapping film from the second wrapping film solution, wherein each of the line segments of the core thread is removed from the second wrapping film solution after the next line segment is immersed into the second wrapping film solution; and obtaining a composite thread wrapped by a second wrapping film by performing a second drying step.
- A composite thread of the invention is manufactured by manufacturing steps as follows: providing a core thread formed of a plurality of line segments connected in series; continuously immersing the core thread into a first wrapping film solution and removing the core thread from the first wrapping film solution, wherein each of the line segments of the core thread is removed from the first wrapping film solution after the next line segment is immersed into the first wrapping film solution; obtaining the core thread wrapped by a first wrapping film by performing a first drying step; continuously immersing the core thread wrapped by the first wrapping film into a second wrapping film solution and removing the core thread wrapped by the first wrapping film from the second wrapping film solution, wherein each of the line segments of the core thread is removed from the second wrapping film solution after the next line segment is immersed into the second wrapping film solution; and obtaining a composite thread wrapped by a second wrapping film by performing a second drying step.
- Based on the above, the composite thread of the invention is formed of a biodegradable material, and may thus be absorbed by an organism. Therefore, the composite thread has a preferable biocompatibility and is suitable to be partially or completely implanted into an organism. When the composite thread is used in a surgery, the composite thread may have the function of sewing and repairing organs such as skin, blood vessels and viscera, etc. In addition, the component in the wrapping film on the composite thread may be spread to the surrounding tissues to achieve an additional assisting function.
- To make the above features and advantages of the invention more comprehensible, embodiments accompanied with drawings are described in detail as follows.
- The accompanying drawings are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification. The drawings illustrate embodiments of the invention and, together with the description, serve to explain the principles of the invention.
-
FIG. 1 is a block diagram illustrating a manufacturing process of a composite thread according to an embodiment of the invention. -
FIG. 2 is a flow chart illustrating a manufacturing process of a composite thread according to an embodiment of the invention. -
FIG. 3 is a cross-sectional schematic view of a composite thread according to an embodiment of the invention. -
FIG. 4 is a schematic view illustrating a coating machine according to an embodiment of the invention. -
FIG. 5A is a view of a polydioxanone (PDO) thread under an electron microscope. -
FIG. 5B is a view of a composite thread wrapped with a first wrapping film under an electron microscope. -
FIG. 5C is a view of a composite thread wrapped with a second wrapping film under an electron microscope. -
FIG. 5D is a view illustrating degradation of a composite thread after 28 days of in vitro test. -
FIG. 6 illustrates a relation between weight loss rates and a degradation time of the composite threads in Examples 1-4. -
FIG. 7 illustrates a relation between pH values and a degradation time in the in vitro degradation test of the composite threads in Examples 1-4. -
FIG. 8 illustrates a test outcome of a cell survival rate of each test sample. -
FIG. 9 illustrates a test outcome of a cell survival rate of each test sample. - Reference will now be made in detail to the present preferred embodiments of the invention, examples of which are illustrated in the accompanying drawings. Wherever possible, the same reference numbers are used in the drawings and the description to refer to the same or like parts.
-
FIG. 1 is a block diagram illustrating a manufacturing process of a composite thread according to an embodiment of the invention.FIG. 2 is a flow chart illustrating the manufacturing process of the composite thread according to the embodiment. Referring toFIGS. 1 and 2 , Step S10 is firstly performed. Acore thread 102 formed of a plurality of line segments connected in series is provided. In other words, thecore thread 102 is a continuous thread formed by connecting the plurality of line segments. - The
core thread 102 may be formed of a biodegradable polymer selected from a group consisting of polyester, polysaccharide, polyamino acid, the copolymers thereof, the blends thereof, and the mixtures thereof, for example. More specifically, thecore thread 102 is selected from a group consisting of poly-glutamic acid, polylysine, polyorthoester, polycaprolactone, polylactide, polyglycolic acid, poly(sebacic acid) polyanhydride, polydioxanone, chitin, fucoidan, the copolymers thereof, the blends thereof, and the mixtures thereof, for example. A biodegradable polymer may be gradually degraded by being absorbed by an organism. Therefore, the biodegradable polymer may be present in the organism for a specific period of time. - Then, Step S20 is performed. The
core thread 102 is continuously immersed into a firstwrapping film solution 204 a and removed from the firstwrapping film solution 204 a. In addition, each of the line segments of thecore thread 102 is removed from the firstwrapping film solution 204 a after the next line segment is immersed into the firstwrapping film solution 204 a. - The first
wrapping film solution 204 a is a solution having a bioactive component, for example. The bioactive component is selected from a group consisting of anti-inflammatory agents, analgesic agents, anesthetic agents, antihistamines, steroids, skin-lightening medicaments, diabetes medicaments, cell growth factors, natural moisture-retaining factors, nucleic acids, peptides, proteins, vitamins, antilipidemic medicaments, anti-cholesterol medicaments, growth hormones, hormones, antioxidizing medicaments, cell growth inhibitors, and differentiation inhibitors, for example. - Specifically, the
core thread 102 may be wound on afeeding thread shaft 202A, for example. Thecore thread 102 may be sequentially disposed on a plurality of rotation shafts and transported by using the rotation shafts. For example, afirst rotation shaft 202 a may be disposed in the firstwrapping film solution 204 a, and asecond rotation shaft 202 b may be disposed outside the firstwrapping film solution 204 a. By rotating thefirst rotation shaft 202 a, thecore thread 102 may be continuously rolled into the firstwrapping film solution 204 a. In this way, the firstwrapping film solution 204 a is coated on a surface of thecore thread 102. Thesecond rotation shaft 202 b may then continuously pull thecore thread 102 out of the firstwrapping film solution 204 a. Thefirst rotation shaft 202 a and thesecond rotation shaft 202 b may have the same rotating speed. A thickness of the firstwrapping film solution 204 a on thecore thread 102 may be determined by adjusting the rotating speed. In addition, when transporting thecore thread 102, thecore thread 102 may have a tensile force due to pulling of thefirst rotation shaft 202 a and thesecond rotation shaft 202 b. In this way, the firstwrapping film solution 204 a may adhere to thecore thread 102 more uniformly, and the usage of the firstwrapping film solution 204 a may be reduced. - Then, Step S30 is performed. The
core thread 102 coated with afirst wrapping film 104 is obtained by performing a first drying step. Specifically, by using thesecond rotation shaft 202 b, thecore thread 102 coated with the firstwrapping film solution 204 a is transported to a heating tube H1 for a heating step, so as to remove a solvent in the firstwrapping film solution 204 a and obtain thefirst wrapping film 104 that is approximately cured. Thefirst wrapping film 104 wraps a surface of thecore thread 102. A temperature in the heating step is approximately between 55° C. to 65° C. - Then, Step S40 is performed. The
core thread 102 wrapped by thefirst wrapping film 104 is continuously immersed into a secondwrapping film solution 204 b and removed from the secondwrapping film solution 204 b. In addition, each of the line segments of thecore thread 102 is removed from the secondwrapping film solution 204 b after the next line segment is immersed into the secondwrapping film solution 204 b. - The second
wrapping film solution 204 a is a solution having a slowly biodegradable component, for example. The slowly biodegradable component is selected from a group consisting of poly-glutamic acid, polylysine, polyorthoester, polycaprolactone, polylactide, polyglycolic acid, polysebacic polyanhydride, polydioxanone, chitin, fucoidan, the copolymers thereof, the blends thereof, and the mixtures thereof, for example. - For example, a
third rotation shaft 202 c may be disposed in the secondwrapping film solution 204 b, and afourth rotation shaft 202 d may be disposed outside the secondwrapping film solution 204 b. By rotating thethird rotation shaft 202 c, thecore thread 102 may be continuously immersed into the secondwrapping film solution 204 b. In this way, the secondwrapping film solution 204 b is coated on the surface of thecore thread 102. Thefourth rotation shaft 202 d may then continuously pull thecore thread 102 out of the secondwrapping film solution 204 b. Thethird rotation shaft 202 c and thefourth rotation shaft 202 d may have the same rotating speed. A thickness of the secondwrapping film solution 204 b on thecore thread 102 may be determined by adjusting the rotating speed. In addition, an additional rotation shaft may be disposed between the rotation shafts, so as to determine a transporting direction and allow the manufacturing process to proceed smoothly. The invention is not limited thereto. When transporting thecore thread 102, thecore thread 102 may have a tensile force due to pulling of thethird rotation shaft 202 c and thefourth rotation shaft 202 d. In this way, the secondwrapping film solution 204 b may adhere to thecore thread 102 more uniformly, and the usage of the secondwrapping film solution 204 b may be reduced. - Then, Step S50 is performed. The
core thread 102 coated with asecond wrapping film 106 is obtained by performing a second drying step. Specifically, by using thefourth rotation shaft 202 d, thecore thread 102 coated with the secondwrapping film solution 204 b is transported to a heating tube H2 for a heating step, so as to remove a solvent in the secondwrapping film solution 204 b and obtain thesecond wrapping film 106 that is approximately cured. Thesecond wrapping film 106 covers a surface of thefirst wrapping film 104. A temperature in the heating step is approximately between 45° C. to 55° C. After the manufacturing process above, thecomposite thread 100 is approximately completed. For an illustrative purpose, thecomposite thread 100 of this embodiment is described as having a plurality of layers (e.g. two layers) of wrapping films, for example. However, the invention is not limited thereto. In other embodiments, thecomposite thread 100 may include only one layer of wrapping film, such as thefirst wrapping film 104 having a bioactive component. -
FIG. 3 is a cross-sectional schematic view of a composite thread according to an embodiment of the invention. Referring toFIGS. 2 and 3 , thecomposite thread 100 includes thecore thread 102, thefirst wrapping film 104, and thesecond wrapping film 106. Thefirst wrapping film 104 wraps the surface of thecore thread 102. Thesecond wrapping film 106 wraps the surface of thefirst wrapping film 104, and thefirst wrapping film 104 is located between thecore thread 102 and thesecond wrapping film 106. - Specifically, the
composite thread 100 is biodegradable. Therefore, thecomposite thread 100 is suitable to be used as a surgical thread in a surgery. In addition, it is not necessary to remove the stitches when using thecomposite thread 100. Besides, the diameter of thecomposite thread 100 of the invention may be designed in a range between 0.05-0.7 mm. The size of thecomposite thread 100 is small and suitable to be implanted into an organism to facilitate the organism to activate a self-repairing process. For example, when thecomposite thread 100 is implanted into a lower layer of dermis at a plurality of points in a plurality of direction through stitches, a three-dimensional mesh structure may be formed to provide more support the skin. In addition, the wound of stitches and thecomposite thread 100 together trigger minor acute reaction and prompt the repairing mechanism of the skin, which release a plurality of growth factors and stimulates the generation of collagen to facilitate the metabolism of the skin and improve the skin quality. - More specifically, the
first wrapping film 104 of thecomposite thread 100 contains a bioactive component that may be released to the organism to achieve an additional assisting effect such as skin-lightening and anti-oxidizing, etc. Thesecond wrapping film 106 contains a slowly biodegradable component having the effect of slowing down spreading, such as slowing down the speed that the bioactive component is spread in the organism, so as to elongate the overall release time of the bioactive component and achieve the function of controlling the release accordingly. In this embodiment, thecore thread 102 and thesecond wrapping film 106 are biodegradable, for example. In addition, the degradation time of thecore thread 102 may be longer than the degradation time of thesecond wrapping film 106. In this way, thesecond wrapping film 106 may be completely degraded before degradation of thecore thread 102 is completed, so as to release the bioactive component in thefirst wrapping film 104 as much as possible. It should be noted that thecomposite thread 100 of the invention is described as having two layers of wrapping films for an illustrative purpose. However, the invention is not limited thereto. In other embodiments, a similar coating process or other processes may be performed to manufacture two or more layers of wrapping films, such that thecomposite thread 100 may have a more variety of composite effects. -
FIG. 4 is a schematic view illustrating a coating machine according to an embodiment of the invention. Referring toFIG. 4 , acoating machine 200 includes the feedingthread shaft 202A, a receivingthread shaft 202B, a plurality ofrotation shafts 202, a plurality of heating tubes H, and a plurality of lifting tables 206. Thecore thread 102 is wound on the feedingthread shaft 202A, and thecore thread 102 may be disposed on the plurality ofrotation shafts 202. A transporting path of thecore thread 102 may be designed by disposing the rotation shafts. Acoating solution 204 may be disposed on the lifting tables 206. The lifting tables 206 may adjust the height of thecoating solution 204. In this way, the transporting path of thecore thread 102 may pass through thecoating solution 204. In addition, the transporting path of thecore thread 102 passes through the heating tube H, so as to obtain a coating layer by removing a solvent in thecoating solution 204. After coating at least two coating layers, the composite thread that is manufactured may be wound on the receivingthread shaft 202B. Here, the method described herein is to form a wrapping film on thecore thread 102 by coating. However, the invention is not limited thereto. - Examples 1 and 2 are described below to illustrate the invention. However, the invention is not limited thereto.
- The core thread is a biodegradable material, which may be absorbed after being embedded into an organism for a period of time. The core thread itself and the product after the core thread is degraded are compatible with cells, and unlikely to induce negative reactions such as an irritative reaction, a foreign body reaction, or an oncogenic reaction, etc.
- In Example 1, the core thread was formed of polydioxanone (PDO), for example. When a PDO thread is embedded into the skin, the thread is capable of promoting microcirculation in local tissues, activating reparative processes of cells, and stimulating collagen production.
- In Example 1, the bioactive component is vitamin C having a skin lightening effect, for example. A preparation method of the first wrapping film solution is provided below. First of all, 10 g of Polyvinylpyrrolidone (PVP) and 50 g of vitamin C were mixed and placed into a beaker having a capacity of 250 ml. Then, 100 ml of deionized water was added. Then, the solution was heated at 37° C. on a heating board and stirred until all solid bodies were completely dissolved. The vitamin C solution as the first wrapping film solution was thus prepared. The concentration of the vitamin C solution is between 25 wt % and 35 wt %.
- The slowly biodegradable component was poly(lactide-co-glycolide) acid (PLGA) copolymer, for example. In addition, a ratio between lactide (LA) and glycolide (GA) was 75:25. A preparation method of the second first wrapping film solution is provided below. First of all, 11 g of the PLGA copolymer having an inherent value (I.V.) at 0.4 was placed into a beaker having a capacity of 250 ml. Then, 100 ml of dichloromethane was added. The solution was then stirred until all solid bodies were completely dissolved. The PLGA copolymer solution, as the second wrapping film solution, is thus prepared. The concentration of the PLGA copolymer solution is about 10 wt %.
- The first heating tube of the coating machine was heated to 60° C. in advance. The second heating tube was heated to 50° C. in advance. The first coating film solution was placed below the first heating tube, and the second coating film solution was placed below the second heating tube. Afterwards, the speed of the receiving thread shaft was set at 0.3 rpm, and the receiving thread shaft started to rotate. At this time, the PDO thread passed through the first wrapping film solution and then the solvent was baked dry by the first heating tube to form the first wrapping film. Then, the PDO thread passed through the second wrapping film solution, and then the solvent was baked dry by the second heating tube to form the second wrapping film. Finally, the receiving thread shaft collected the composite thread that was manufactured. The time duration that the PDO thread is absorbed by the human body is approximately 180 to 240 days. The time duration that the PLGA copolymer wrapping film is absorbed by the human body is about 28 days.
- The manufacturing process described in Example 2 is similar to that described in Example 1, but the bioactive component in Example 2 is different from that in Example 1. In Example 2, the bioactive component was vitamin E having an anti-oxidizing effect, for example. A preparation method of the first wrapping film solution is provided below. First of all, 10 g of Polyvinylpyrrolidone (PVP) and 50 g of vitamin E were mixed and placed into a beaker having a capacity of 250 ml. Then, 100 ml of methylene chloride was added. Then, the solution was stirred until all solid bodies were completely dissolved. The vitamin E solution as the first wrapping film solution was thus prepared. The concentration of the vitamin E solution is between 25 wt % and 35 wt %.
- The composite thread of Example 3 is similar to that of Example 1. The bioactive components in Examples 1 and 3 were Vitamin C. However, Example 3 differs from Example 1 in that the inherent value of the PLGA copolymer in Example 3 was 0.8. The composite thread of Example 4 is similar to that of Example 2. The bioactive components in Examples 2 and 4 were Vitamin E. However, Example 4 differs from Example 2 in that the inherent value of the PLGA copolymer in Example 4 was 0.8.
-
FIG. 5A is a view of a polydioxanone (PDO) thread under an electron microscope.FIG. 5B is a view of a composite thread wrapped with a first wrapping film under an electron microscope.FIG. 5C is a view of a composite thread wrapped with a second wrapping film under an electron microscope.FIG. 5D is a view illustrating degradation of a composite thread after 28 days of the in vitro test. Referring toFIG. 5A , before coating of the active component (i.e. without the first wrapping film), there were a plurality of strip-like cracks on a lateral surface of the thread. Referring toFIG. 5B , after the first wrapping film was formed, the lateral surface of the composite thread became more complete. Referring toFIG. 5C , after the second wrapping film was formed, a plurality of pores were formed on the lateral surface of the composite thread. The pores were formed when the solvent (e.g. dichloromethane) in the PLGA copolymer wrapping film solution having a viscosity to a certain degree (e.g. I.V. at 0.4) was evaporated when the solution was heated. Referring toFIG. 5D , it is shown that after 28 days of the in vitro test, the second wrapping film was degraded, and the biodegradability of the second wrapping film is thus shown. Since the second wrapping film is slowly degraded within a period of time, the component of the first wrapping film may be slowly released to the body of an organism, so as to control the bioactive component to be slowly released. - A degradation test on the composite threads of Examples 1-4 are described below. The test procedure is described as follows. First of all, the composite threads that were weighted were placed in test tubes. Then, 5 ml of normal saline (phosphate buffer saline, PBS) having a pH value at 7.4 was added to the test tubes where the samples are placed. Then, the test tubes were placed in a thermostatic tank having a temperature set at 37° C. After a fixed period of time, the samples were taken out to be dried and weighted. Then, pH values of the liquids in the test tubes were measured.
-
FIG. 6 illustrates a relation between weight loss rates and a degradation time of the composite threads in Examples 1-4. As shown inFIG. 6 , the longer the degradation duration time was, the lower the weight of each of the composite threads became, indicating that the first wrapping film and the second wrapping film on the composite threads were gradually peeled off through time. -
FIG. 7 illustrates a relation between pH values and a degradation time in the in vitro degradation test of the composite threads in Examples 1-4. Referring toFIG. 7 , as the second wrapping film was gradually dissolved, the PLGA copolymer was gradually released to the liquids in the test tubes. Therefore, the pH values gradually dropped. - The in vitro test of cell survival rate on a plurality of composite threads is described below. The test described herein was conducted in accordance with the standard of ISO 10993-5. The test samples included a PDO composite thread coated with a wrapping film having 8 wt % of vitamin C, a PDO composite thread coated with a wrapping film having 15 wt % of vitamin C, a PDO composite thread coated with a wrapping film having 4 wt % of vitamin E, and a PDO composite thread coated with a wrapping film having 8 wt % of vitamin E. In addition, a blank control group (incubated with 5 ml of the minimum essential medium (MEM) culture medium containing bovine serum), a negative control group (a PE film, extracted at 37° C. for 24 hours at the ratio of 6 cm2/mL), and a positive control group (incubated with 0.2% of phenol) were also included.
- The used MEM extracts were prepared in accordance with the standard of ISO 10993-12. The test samples were mixed with the MEM extracts at the ratio of 6 cm2/mL. Then the MEM extracts were used to extract the test samples at 37° C. for 24 hours, so as to obtain an extract of each of the test samples. Then, the extract of each of the test samples was co-cultured with a mouse fibroblast strain L929 (NCTC clone 929) for 72 hours under a condition of 5% of CO2 at 37° C. Then, a MTT assay, a quantitative analysis, was performed to test the cell survival rate.
FIG. 8 illustrates a test outcome of the cell survival rate of each test sample. As shown inFIG. 8 , the composite thread of the invention had a higher cell survival rate, indicating that the composite thread of the invention has a higher biocompatibility. - In addition, the same test was performed on different test samples to test the in vitro cell survival rate. Here, the test samples included a PDO thread coated with 31 wt % of the vitamin C wrapping film and PLGA copolymer wrapping film and a PDO thread coated with 31 wt % of the vitamin E wrapping film and PLGA copolymer wrapping film.
FIG. 9 illustrates a test outcome of the cell survival rate of each test sample. From the experiments, for the test samples using the composite thread of the invention, at least 80 percent of cell viability was observed. - In view of the foregoing, the composite thread of the invention is formed of a biodegradable material, and may thus be absorbed by an organism. Therefore, the composite thread of the invention has a preferable biocompatibility and is suitable to be partially or completely implanted into an organism. When the composite thread is used in a surgery, the composite thread may have the function of sewing and repairing organs such as skin, blood vessels, and viscera, etc. In addition, the component in the wrapping film on the composite thread may be spread to the surrounding tissues to achieve an additional assisting function.
- It will be apparent to those skilled in the art that various modifications and variations can be made to the structure of the present invention without departing from the scope or spirit of the invention. In view of the foregoing, it is intended that the invention covers modifications and variations of this invention provided they fall within the scope of the following claims and their equivalents.
Claims (13)
1. A composite thread, comprising:
a core thread; and
at least one wrapping film, wrapping a surface of the core thread.
2. The composite thread as claimed in claim 1 , wherein the composite thread is formed of a biodegradable polymer.
3. The composite thread as claimed in claim 2 , wherein the biodegradable polymer is selected from a group consisting of polyester, polysaccharide, polyaminoacid, the copolymers thereof, the blends thereof, and the mixtures thereof.
4. The composite thread as claimed in claim 2 , wherein the biodegradable polymer is selected from a group consisting of poly-glutamic acid, polylysine, polyorthoester, polycaprolactone, polylactide, polyglycolic acid, polysebacic polyanhydride, polydioxanone, chitin, fucoidan, the copolymers thereof, the blends thereof, and the mixtures thereof.
5. The composite thread as claimed in claim 1 , wherein at least one of the at least one wrapping film has a bioactive component.
6. The composite thread as claimed in claim 5 , wherein the bioactive component is selected from a group consisting of anti-inflammatory agents, analgesic agents, anesthetic agents, antihistamines, steroids, skin-lightening medicaments, diabetes medicaments, cell growth factors, natural moisture-retaining factors, nucleic acids, peptides, proteins, vitamins, antilipidemic medicaments, anti-cholesterol medicaments, growth hormones, hormones, antioxidizing medicaments, cell growth inhibitors, and differentiation inhibitors.
7. The composite thread as claimed in claim 5 , wherein the at least one wrapping film is a plurality of layers of wrapping films, and one of the wrapping film has a slowly biodegradable component.
8. The composite thread as claimed in claim 7 , wherein the slowly biodegradable component is selected from a group consisting of poly-glutamic acid, polylysine, polyorthoester, polycaprolactone, polylactide, polyglycolic acid, polysebacic polyanhydride, polydioxanone, chitin, fucoidan, the copolymers thereof, the blends thereof, and the mixtures thereof.
9. A manufacturing process of a composite thread, comprising:
providing a core thread formed of a plurality of line segments connected in series;
continuously immersing the core thread into a first wrapping film solution and removing the core thread from the first wrapping film solution, wherein each of the line segments of the core thread is removed from the first wrapping film solution after the next line segment is immersed into the first wrapping film solution;
obtaining the core thread wrapped by a first wrapping film by performing a first drying step;
continuously immersing the core thread wrapped by the first wrapping film into a second wrapping film solution and removing the core thread wrapped by the first wrapping film from the second wrapping film solution, wherein each of the line segments of the core thread is removed from the second wrapping film solution after the next line segment is immersed into the second wrapping film solution; and
obtaining a composite thread wrapped by a second wrapping film by performing a second drying step.
10. The manufacturing process of the composite thread as claimed in claim 9, wherein the method of continuously immersing the core thread into the first wrapping film solution and removing the core thread from the first wrapping film solution comprises:
disposing a first rotation shaft in the first wrapping film solution, and continuously rolling the core thread into the first wrapping film solution by using the first rotation shaft; and
disposing a second rotation shaft outside the first wrapping film solution, and continuously removing the core thread from the first wrapping film solution by using the second rotation shaft.
11. The manufacturing process of the composite thread as claimed in claim 9 , wherein the method of continuously immersing the core thread wrapped by the first wrapping film into the second wrapping film solution and removing the core thread wrapped by the first wrapping film from the second wrapping film solution comprises:
disposing a third rotation shaft in the second wrapping film solution, and continuously rolling the core thread wrapped by the first wrapping film into the second wrapping film solution by using the third rotation shaft; and
disposing a fourth rotation shaft outside the second wrapping film solution, and continuously removing the core thread from the second wrapping film solution by using the fourth rotation shaft.
12. The manufacturing process of the composite thread as claimed in claim 9 , wherein the first drying step or the second drying step comprises a heating step.
13. A composite thread, manufactured by manufacturing steps as follows:
providing a core thread formed of a plurality of line segments connected in series;
continuously immersing the core thread into a first wrapping film solution and removing the core thread from the first wrapping film solution, wherein each of the line segments of the core thread is removed from the first wrapping film solution after the next line segment is immersed into the first wrapping film solution;
obtaining the core thread wrapped by a first wrapping film by performing a first drying step;
continuously immersing the core thread wrapped by the first wrapping film into a second wrapping film solution and removing the core thread wrapped by the first wrapping film from the second wrapping film solution, wherein each of the line segments of the core thread is removed from the second wrapping film solution after the next line segment is immersed into the second wrapping film solution; and
obtaining a composite thread wrapped by a second wrapping film by performing a second drying step.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
TW103116544A TW201542253A (en) | 2014-05-09 | 2014-05-09 | Composite thread and manufacture process thereof |
TW103116544 | 2014-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
US20150322596A1 true US20150322596A1 (en) | 2015-11-12 |
Family
ID=54367317
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/490,680 Abandoned US20150322596A1 (en) | 2014-05-09 | 2014-09-19 | Composite thread and manufacture process thereof |
Country Status (3)
Country | Link |
---|---|
US (1) | US20150322596A1 (en) |
CN (1) | CN105079867A (en) |
TW (1) | TW201542253A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109183244A (en) * | 2018-07-27 | 2019-01-11 | 嘉兴市莱森服饰有限公司 | A kind of chitin fiber and the compound antibiotic fabric of long-staple cotton |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105442133A (en) * | 2015-12-15 | 2016-03-30 | 桐乡市濮院羊毛衫职业技术学校 | Compound type yarn |
CN107213507A (en) * | 2017-07-03 | 2017-09-29 | 武汉医佳宝生物材料有限公司 | A kind of absorbable suture and preparation method thereof |
CN108853562A (en) * | 2018-09-13 | 2018-11-23 | 王传强 | A kind of absorbable pre-knotted operation suture thread of thoracic surgery sustained antiinfective |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6315788B1 (en) * | 1994-02-10 | 2001-11-13 | United States Surgical Corporation | Composite materials and surgical articles made therefrom |
US20050149118A1 (en) * | 2003-12-18 | 2005-07-07 | Ilya Koyfman | High strength suture with absorbable core and suture anchor combination |
US20130317545A1 (en) * | 2010-11-03 | 2013-11-28 | Jeffrey M. Gross | Drug-eluting self-retaining sutures and methods relating thereto |
US20150032155A1 (en) * | 2013-07-24 | 2015-01-29 | Arthrex, Inc. | Hybrid suture with monofilament and braided construction |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102698315B (en) * | 2012-06-26 | 2014-01-15 | 单县润康缝合材料有限公司 | Coating method of antibacterial surgical suture made of high molecular absorbable material |
CN103215779B (en) * | 2013-04-08 | 2015-04-08 | 东华大学 | Device and method for preparing sustainable-released antibacterial real-silk braided suture line |
-
2014
- 2014-05-09 TW TW103116544A patent/TW201542253A/en unknown
- 2014-06-27 CN CN201410301420.3A patent/CN105079867A/en active Pending
- 2014-09-19 US US14/490,680 patent/US20150322596A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6315788B1 (en) * | 1994-02-10 | 2001-11-13 | United States Surgical Corporation | Composite materials and surgical articles made therefrom |
US20050149118A1 (en) * | 2003-12-18 | 2005-07-07 | Ilya Koyfman | High strength suture with absorbable core and suture anchor combination |
US20130317545A1 (en) * | 2010-11-03 | 2013-11-28 | Jeffrey M. Gross | Drug-eluting self-retaining sutures and methods relating thereto |
US20150032155A1 (en) * | 2013-07-24 | 2015-01-29 | Arthrex, Inc. | Hybrid suture with monofilament and braided construction |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109183244A (en) * | 2018-07-27 | 2019-01-11 | 嘉兴市莱森服饰有限公司 | A kind of chitin fiber and the compound antibiotic fabric of long-staple cotton |
Also Published As
Publication number | Publication date |
---|---|
CN105079867A (en) | 2015-11-25 |
TW201542253A (en) | 2015-11-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111803710B (en) | Composite tissue repair patch prepared by tape casting process and preparation method thereof | |
Jeffries et al. | Highly elastic and suturable electrospun poly (glycerol sebacate) fibrous scaffolds | |
US9295462B2 (en) | Suture comprising drug-loaded polymer layer and method of manufacturing the same | |
US20150322596A1 (en) | Composite thread and manufacture process thereof | |
ES2834498T3 (en) | Medical implants including poly-4-hydroxybutyrate laminates and copolymers thereof | |
EP1957695A1 (en) | Drug-delivering composite structures | |
US8834915B2 (en) | Drug-containing bioabsorbable fibers and implants | |
ES2805803T3 (en) | Thermoformed Poly-4-Hydroxybutyrate Medical Implants | |
WO2008016163A1 (en) | Crosslinked gelatin gel multilayered structure, carrier for bioactive factor, preparation for release of bioactive factor, and their production methods | |
Argarate et al. | Biodegradable Bi-layered coating on polymeric orthopaedic implants for controlled release of drugs | |
US20120251752A1 (en) | Porous member, porous-making method, and method of producing porous member | |
US20120004199A1 (en) | Scaffolds | |
CN110170068B (en) | Multi-functional medical suture and preparation method thereof | |
CN102727946B (en) | Drug loaded coating and its preparation method | |
Scapin et al. | Use of triethylcitrate plasticizer in the production of poly-L-lactic acid implants with different degradation times | |
TWM502442U (en) | Composite thread | |
EP3452128B1 (en) | Modified biodegradable and medical polymer devices and a method for preparing the same | |
US20110183064A1 (en) | Method For Coating Medication On Medical Article | |
Leung | Engineering design of nanofibre wound dressings | |
CN108619569B (en) | Three-layer artificial blood vessel electrospinning membrane loaded with micro nucleic acid and preparation method and application thereof | |
CN106867020B (en) | A kind of temperature-induced self-healing porous material and its preparation method and application | |
KR20230172789A (en) | Bio-degradable composite and manufacturing method for the same | |
Bhatnagar et al. | Protein-Based Microneedles for Drug and Vaccine Delivery | |
JP2020188906A (en) | Bioabsorbable suture thread | |
WO2020206067A1 (en) | Bioabsorbable membrane for tissue regeneration and process for preparing the same |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BIO-LINE MEDICAL TECH CO., LTD, TAIWAN Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:LIN, JUI-YU;REEL/FRAME:033811/0861 Effective date: 20140917 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |