US20150018860A1 - Methods and apparatus for treating small vessel thromboembolisms - Google Patents
Methods and apparatus for treating small vessel thromboembolisms Download PDFInfo
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- US20150018860A1 US20150018860A1 US14/299,997 US201414299997A US2015018860A1 US 20150018860 A1 US20150018860 A1 US 20150018860A1 US 201414299997 A US201414299997 A US 201414299997A US 2015018860 A1 US2015018860 A1 US 2015018860A1
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- embolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B17/3205—Excision instruments
- A61B17/3207—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions
- A61B17/320725—Atherectomy devices working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions with radially expandable cutting or abrading elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00743—Type of operation; Specification of treatment sites
- A61B2017/00778—Operations on blood vessels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22031—Gripping instruments, e.g. forceps, for removing or smashing calculi
- A61B2017/22034—Gripping instruments, e.g. forceps, for removing or smashing calculi for gripping the obstruction or the tissue part from inside
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/32—Surgical cutting instruments
- A61B2017/320004—Surgical cutting instruments abrasive
- A61B2017/320008—Scrapers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/0105—Open ended, i.e. legs gathered only at one side
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/011—Instruments for their placement or removal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2/012—Multiple filtering units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/01—Filters implantable into blood vessels
- A61F2002/016—Filters implantable into blood vessels made from wire-like elements
Definitions
- the present technology relates generally to devices and methods for intravascular treatment of stroke, myocardial infarction and other small vessel thromboembolisms. Many embodiments of the technology relate to the intravascular removal of an embolism within a blood vessel associated with the brain, heart or peripheral vasculature.
- Thromboembolism occurs when a thrombus or blood clot trapped within a blood vessel breaks loose and travels through the blood stream to another location in the circulatory system, resulting in a clot or obstruction at the new location.
- Thromboembolisms in small blood vessels can be particularly difficult to treat intravascularly due to the limited space within the vessel at the target site.
- Acute ischemic stroke is caused by a thrombus traveling through the brain and lodging in a cerebral artery, thereby causing thrombotic or embolic occlusion of the cerebral artery.
- Small vessel thromboembolisms can also lead to myocardial infarction (MI) or “heart attack”. An MI requires immediate medical attention. Treatment includes attempts to save as much viable heart muscle as possible and to prevent further complications. Small vessel thromboembolisms can also lead to peripheral vascular disease (PVD) and/or peripheral arterial disease (PAD).
- PVD peripheral vascular disease
- PAD peripheral arterial disease
- Conditions associated with PVD that affect the veins include deep vein thrombosis (DVT), varicose veins, and chronic venous insufficiency.
- Lymphedema is an example of PVD that affects the lymphatic vessel.
- Conditions associated with PAD may be occlusive (occurs because the artery becomes blocked in some manner) or functional (the artery either constricts due to a spasm or expands).
- occlusive PAD include peripheral arterial occlusion and Buerger's disease (thromboangiitis obliterans).
- Examples of functional PAD include Raynaud's disease and phenomenon and acrocyanosis.
- thromboembolism in small vessels
- anticoagulants can be introduced to the affected vessel to prevent additional clots from forming
- thrombolytics can be introduced to the vessel to at least partially disintegrate the clot.
- agents typically take a prolonged period of time (e.g., hours, days, etc.) before the treatment is effective and in some instances can cause bleeding complications including major bleeding and intracranial hemorrhaging.
- Transcatheter clot removal devices also exist, however, such devices are typically highly complex, prone to cause trauma to the vessel, hard to navigate to the embolism site, and/or expensive to manufacture.
- Conventional approaches also include surgical techniques that involve opening the chest cavity and dissecting the vessel. Such surgical procedures, however, come with increased cost, procedure time, risk of infection, higher morbidity, higher mortality, and recovery time. Accordingly, there is a need for devices and methods that address one or more of these deficiencies.
- FIG. 1 is a schematic illustration of an embolism traveling through the brain and forming an embolism in a cerebral blood vessel.
- FIG. 2A is a perspective view of one embodiment of a clot treatment device in a collapsed or delivery state configured in accordance with an embodiment of the present technology.
- FIG. 2B is a perspective view of the clot treatment device of FIG. 2A in a deployed state configured in accordance with an embodiment of the present technology.
- FIG. 2C is an enlarged view of a portion the clot treatment device shown in FIG. 2A .
- FIG. 2D is an axial-perspective view of a portion of the clot treatment device shown in FIG. 2A .
- FIGS. 3A-3C are isolated, enlarged side views of clot engagement members in a deployed state configured in accordance with embodiments of the present technology.
- FIG. 4A is a perspective view of another embodiment of a clot treatment device in a collapsed or delivery state configured in accordance with an embodiment of the present technology.
- FIG. 4B is a perspective view of the clot treatment device of FIG. 4A in a deployed state configured in accordance with an embodiment of the present technology.
- FIG. 5 is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology.
- FIG. 6 is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology.
- FIG. 7A is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology.
- FIG. 7B is a cross-sectional end view taken along line 7 B- 7 B in FIG. 7A .
- FIG. 8 is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology.
- FIG. 9A is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology.
- FIG. 9B is a cross-sectional end view of a portion of the clot treatment device shown in FIG. 9A .
- FIG. 9C is a side view of a binding member configured in accordance with the present technology.
- FIG. 10 is a side partial cross-sectional view of a delivery system configured in accordance an embodiment of the present technology.
- FIGS. 11A-11K illustrate a method for using a clot treatment device configured in accordance with the present technology to remove clot material from a vessel.
- FIGS. 2A-11K Specific details of several embodiments of clot treatment devices, systems and associated methods in accordance with the present technology are described below with reference to FIGS. 2A-11K . Although many of the embodiments are described below with respect to devices, systems, and methods for treating small vessel thromboemboli within the heart, brain and peripheral vasculature, other applications and other embodiments in addition to those described herein are within the scope of the technology (for example, small vessels in other parts of the vasculature). As used herein, “small vessel” refers to any portion of the vasculature having an inner diameter less than about 6 mm. Additionally, several other embodiments of the technology can have different states, components, or procedures than those described herein.
- distal and proximal within this description, unless otherwise specified, the terms can reference a relative position of the portions of a clot treatment device and/or an associated delivery device with reference to an operator and/or a location in the vasculature.
- FIG. 2A is a perspective view of one embodiment of a clot treatment device 200 (“the device 200 ”) in a low-profile or delivery state
- FIG. 2B is a perspective view of the device 200 in an unrestricted expanded or deployed state that is well suited for removing clot material from a small blood vessel (e.g., a cerebral blood vessel).
- the device 200 can include a support member 204 and a plurality of clot engagement members 202 positioned about the circumference of the support member 204 . As best shown in FIG.
- the individual clot engagement members 202 can include a first portion 206 having a proximal region 205 and a distal region 207 , and a second portion 208 extending from the distal region 207 of the first portion 206 .
- the clot engagement members 202 can be generally linear and extend generally parallel to the support member 204 .
- the second portions 208 can project radially outwardly relative to the support member 204 in a curved shape.
- the second portions 208 can have a proximally facing section 212 which defines a proximally facing concave portion, and, in some embodiments, the second portions 208 can further include an end section 214 that curves radially inwardly from the proximally facing section 212 .
- the clot engagement members 202 When deployed within a blood vessel adjacent to clot material, the clot engagement members 202 are configured to penetrate the clot material along an arcuate path and hold clot material to the device 200 , as discussed in greater detail below with reference to FIGS. 10-11K .
- FIG. 2C is an enlarged view of a portion of the device 200 of FIG. 2A showing that the device 200 can include a hub 210 that couples the proximal regions 205 of the first portions 206 to the support member 204 .
- the first portions 206 can extend distally from their proximal regions 205 in a longitudinal direction along the length of the support member 204 to their distal regions 207 , and the distal regions 207 can be free to move relative to the support member 204 .
- the first portions 206 can be cantilevered portions of the clot engagement members 202 that enable the clot engagement members 202 to flex and move independently of the support member 204 in response to forces present within the blood vessel, such as blood flow, gravity, and/or the local anatomy.
- the first portions 206 can be sufficiently rigid to maintain a generally linear shape along their respective lengths, yet flexible enough to bend and/or flex about the hub 210 .
- one or more of the distal regions 207 of the first portions 206 can be spaced radially apart from the support member 204 such that one or more first portions 206 forms an angle with the support member 204 .
- the first portions 206 of different clot engagement members 202 can have different lengths such that the second portions 208 of at least two clot engagement members extend radially outwardly at different locations along the length of the support member 204 .
- the second portions 208 of at least two clot engagement members extend radially outwardly at different locations along the length of the support member 204 .
- the clot treatment device 200 can include a first group 202 a of clot engagement members 202 having first portions 206 with a first length L 1 , a second group 202 b of clot engagement members 202 having first portions 206 with a second length L 2 greater than the first length L 1 , a third group of clot engagement members 202 c having first portions 206 with a third length L 3 greater than the second length L 2 , a fourth group of clot engagement members 202 d having first portions 206 with a fourth length L 4 greater than the third length L 3 , a fifth group of clot engagement members 202 e having first portions 206 with a fifth length L 5 greater than the fourth length L 4 , and a sixth group of clot engagement members 202 f having first portions 206 with a sixth length L 6 greater than the fifth length L 5 .
- the clot treatment device can have more or fewer than six groups (e.g., one group, two groups, three groups, seven groups, ten groups, etc.) and/or the lengths of all or some of the first portions 206 can be the same or different.
- the second portions 208 of the first group 202 a of clot engagement members 202 extend radially outward at a first area of the support member 204
- the second portions 208 of the second group 202 b of the clot engagement members 202 extend radially outward from a second area of the support member 204
- the second portions 208 of the third group 202 c of clot engagement members 202 extend radially outward from a third area of the support member 204
- the second portions 208 of the fourth group 202 d of clot engagement members 202 extend radially outward from a fourth area of the support member 204
- the second portions 208 of the fifth group 202 e of clot engagement members 202 extend radially outward from a fifth area of the support member 204
- the second portions 208 of the sixth group 202 f of clot engagement members 202 extend radially outward from a sixth area of the support member 204 .
- the clot treatment device can have more or fewer than six areas (e.g., one area, two areas, three areas, five areas, nine areas, etc.).
- FIG. 2D is an enlarged, axial-perspective view of a portion of the device 200 in which the groups of clot engagement members 202 a - f (only the first, second and third groups 202 a - c shown) are arranged about the circumference of the support member 204 such that the second portions (labeled 208 a - c ) of adjacent groups 202 a - c are circumferentially offset from one another.
- the second portions 208 of adjacent groups of clot engagement members 202 a - f are not circumferentially aligned, and thus can engage the clot material at different circumferential positions along the length of the clot material.
- FIG. 3A is a side view of a clot engagement member 202 in the expanded state.
- Individual clot engagement members can be made from a shape memory material such that, when unconstrained, assume a preformed curved shape.
- the second portion 208 can have an arcuate shape that includes an outwardly extending section 216 , the proximally facing section 212 extending from the outwardly extending section 216 , and the end section 214 extending from the proximally facing section 212 .
- the demarcation between the proximally facing section 212 and the end section 214 occurs at an apex 218 of the second portion 208 .
- the proximally facing section 212 is configured to retain clot material with the clot engagement member 202 as the device 200 is pulled proximally through the vessel (arrow P), and the apex 218 provides a smooth curve that can atraumatically slide along the vessel wall as the device 200 is pulled proximally through the vessel.
- the second portion 208 of the clot treatment device 200 can have a single or constant radius of curvature R 1 .
- R 1 In other embodiments, such as the clot engagement member 402 shown in FIG.
- the second portions 208 can have a plurality of radii of curvature, such as a first region with a first radius of curvature R 1 and a second region with a second radius of curvature R 2 .
- the second portions 208 of the clot engagement members 202 have a single radius of curvature that is the same for all of the clot engagement members 202 .
- the device 200 can have a first group of second portions with a constant radius of curvature and a second group of second portions with a plurality of radii of curvature.
- the device 200 can include a first group of second portions having a first radius of curvature and a second group of second portions having a second radius of curvature different than the first radius of curvature.
- the radius R 1 of the clot engagement members 202 can be between about 0.15 mm and about 3 mm, and in some embodiments, between about 0.25 mm and about 2 mm.
- the arc length a of the clot engagement members 202 may be substantially greater than 180 degrees to provide several benefits in performance of clot engagement and retrieval.
- a greater arc length a can provide improved clot engagement during retraction when resistance due to clot friction and interference with the vessel wall deflects the clot engagement member 202 distally (arrow D).
- a greater arc length a may provide more deflection and/or unravelling or straightening of the arcuate shape without loss of engagement with the clot.
- the arc length a of the clot engagement members 202 can be greater than about 200 degrees.
- the arc length a of the clot engagement members 202 may be between about 200 degrees and 340 degrees and between about 240 degrees and 300 degrees in other embodiments. It can be advantageous to keep the arc length a under about 360 degrees so as to avoid overlap of the clot engagement member 202 . Greater arc length a can allow for the use of smaller clot engagement member filaments or wires that may be particularly beneficial for minimization of the collapsed profile of the device. Greater arc length a can also allow for a larger total number of clot engagement members 202 that also enhance the ability of the device to remove embolic material from a small vessel.
- the distal end of the clot engagement members 202 may define an angle with respect to the axis of the support member and/or the straight portion of the engagement members (as shown in FIG. 3C ). This angle may be between about 30 degrees and about 90 degrees, and in some embodiments between about 40 degrees and about 80 degrees.
- the clot engagement members 202 can be made from a variety of materials.
- the clot engagement members 202 comprise a material with sufficient elasticity to allow for repeated collapse into an appropriately sized catheter and full deployment in a blood vessel.
- suitable metals can include nickel-titanium alloys (e.g., Nitinol), platinum, cobalt-chrome alloys, Elgiloy, stainless steel, tungsten, titanium and/or others. Polymers and metal/polymer composites can also be utilized in the construction of the clot engagement members.
- Polymer materials can include Dacron, polyester, polyethylene, polypropylene, nylon, Teflon, PTFE, ePTFE, TFE, PET, TPE, PLA silicone, polyurethane, polyethylene, ABS, polycarbonate, styrene, polyimide, PEBAX, Hytrel, polyvinyl chloride, HDPE, LDPE, PEEK, rubber, latex and the like.
- the clot engagement members 202 may comprise an environmentally responsive material, also known as a smart material. Smart materials are designed materials that have one or more properties that can be significantly changed in a controlled fashion by external stimuli, such as stress, temperature, moisture, pH, electric or magnetic fields.
- portions of the exterior surfaces of the support member 204 and/or clot engagement members 202 may be textured, or the exterior surfaces can include microfeatures configured to facilitate engagement or adhesion of thrombus material (e.g., ridges, bumps, protrusions, grooves, cut-outs, recesses, serrations, etc.).
- the clot engagement members 202 may be coated with one or more materials to promote platelet activation or adhesion of thrombus material. Adhesion of thrombi to clot engagement members 202 may facilitate capture and/or removal.
- the clot treatment device 200 can include between about 20 and about 140 clot engagement members 202 , and in some embodiments, between about 40 and about 120 clot engagement members 202 .
- the clot engagement members 202 can individually have one consistent diameter or have a variety of diameters (among the members 202 ) along their lengths.
- an individual clot engagement member 202 may have a tapered or varying diameter along its length to provide desired mechanical characteristics.
- the average diameter of the clot engagement members 202 can be between about 0.02 mm to about 0.1 mm in some embodiments and in a particular embodiment, between about 0.04 mm and 0.08 mm.
- the clot engagement members 202 can be formed from a filament or wire having a circular cross-section. Additionally, the clot engagement members 202 can be formed from a filament or wire having a non-circular cross-section. For example, filaments or wires having square, rectangular and oval cross-sections may be used.
- a rectangular wire also known as a “flat wire” may have a height or radial dimension of between about 0.02 mm to about 0.1 mm.
- a rectangular wire may have a width or transverse dimension of between about 0.02 mm to about 0.08 mm.
- a rectangular wire may have a height to width ratio of between about 0.3 to about 0.9 and between about 1 and about 1.8.
- FIGS. 4A and 4B illustrate an embodiment in which clot engagement members having non-circular cross-sections can be fabricated from a tube (e.g., a hypotube).
- the tube may be cut or machined by various means known in the art including conventional machining, laser cutting, electrical discharge machining (EDM) or photochemical machining (PCM).
- EDM electrical discharge machining
- PCM photochemical machining
- a tube may be cut to form a plurality of clot engagement members 454 that are integral with a hub member 456 .
- the cut tube may then be formed by heat treatment to move from a delivery state shown in FIG. 4A to a deployed state shown in FIG. 4B in which an array of arcuate clot engagement members 454 project radially outward.
- a fixture or mold may be used to hold the structure in its desired final configuration and subjected to an appropriate heat treatment such that the clot engagement members assume or are otherwise shape-set to the desire arcuate shape.
- the device or component may be held by a fixture and heated to about 475-525° C. for about 5-15 minutes to shape-set the structure.
- the tubular clot engagement structure may be formed from various metals or alloys such as Nitinol, platinum, cobalt-chrome alloys, 35N LT, Elgiloy, stainless steel, tungsten or titanium.
- FIG. 5 is a perspective view of another embodiment of a clot treatment device 500 in a deployed state in accordance with the present technology.
- the clot treatment device 500 can include a plurality of clot engagement members 502 generally similar to the clot engagement members 202 and 402 described with reference to FIGS. 2A-4B , except the clot engagement members 502 of FIG. 5 are arranged about the support member 204 such that the length of the first portions 506 increase in a clockwise or counterclockwise direction about 360 degrees of the support member 204 .
- the second portions 508 spiral around the length of the support member 204 and each successive second portion 508 extending from a location along the shaft that is circumferentially offset and distal to the location of the immediately adjacent second portion 508 .
- FIG. 6 is a perspective view of another embodiment of a clot treatment device 600 in a deployed state in accordance with the present technology.
- the clot treatment device 600 can include a plurality of clot engagement members 602 generally similar to the clot engagement members 202 and 402 described with reference to FIGS. 2A-4B , except the second portions 608 of the clot engagement members 602 of FIG. 6 are not arranged in groups, but instead extend at irregular intervals from support member 204 .
- FIG. 7A is a perspective view of another embodiment of a clot treatment device 700 in a deployed state in accordance with the present technology
- FIG. 7B is a cross-sectional end view taken along line 7 B- 7 B in FIG. 7A
- the clot treatment device 700 can have groups of clot engagement members 702 a - f spaced along the support member 204 .
- the groups 702 a - f can include a plurality of arcuate clot engagement members 702 generally similar to the clot engagement members 202 and 402 described with reference to FIGS. 2A-4B , except the second portions 708 of the clot engagement members 702 of FIG.
- the second portions 708 can extend at an angle ⁇ from the first portions 706 .
- the angle ⁇ can be between about 10 and about 80 degrees.
- the angle ⁇ can be between about 40 and about 60 degrees.
- the clot engagement members may form a substantially circular axial array about the axis of the support member. A circular array may engage clot more uniformly and securely than a non-circular array and thus may facilitate retrieval and removal of clot from the vessel.
- FIG. 8 is a perspective view of another embodiment of a clot treatment device 800 in a deployed state in accordance with the present technology.
- the clot treatment device 800 can have groups of clot engagement members 802 a - f spaced along the support member 204 .
- the groups 802 a - f can include a plurality of arcuate clot engagement members 802 generally similar to the clot engagement members 202 and 402 described with reference to FIGS. 2A-4B , except the clot engagement members 802 of FIG. 8 do not include a first or cantilevered portion.
- the clot engagement members 802 include only a curved second portion 808 which is coupled to the support member 204 at one end (e.g., via hubs 810 a - f ). In other embodiments, however, the clot engagement members 802 can have relatively short first portions (e.g., less than about 10 mm (e.g., less than about 5 mm, less than about 3 mm, less than about 2 mm, etc.)). In some embodiments, the groups 802 a - f can be evenly spaced along the support member 204 , and in other embodiments the groups 802 a - f can have any spacing or state along the support member 204 .
- arcuate clot engagement members 802 at one group 802 can have a different size than the arcuate clot engagement members 802 at a different group 802 .
- the groups 802 a - f can be deployed or expanded simultaneously (e.g., via a push-wire or other deployment methods) or consecutively (e.g., by retracting a sheath).
- FIG. 9A is a perspective view of another embodiment of a clot treatment device 1200 in a deployed state configured in accordance with the present technology.
- the device 1200 can include a plurality of clot engagement members 1202 arranged in closely-packed circular array.
- the clot engagement members 1202 can be generally similar to the clot engagement members 202 and 402 described with reference to FIGS. 2A-4B .
- a proximal portion of the clot engagement members 1202 can be bound together and surrounded by a tubular binding member 1210 .
- the clot engagement members 1202 can fill substantially all of a lumen of the binding member 1210 , as shown in the cross-sectional view of FIG.
- the clot engagement members 1202 can have first portions 1206 with differing lengths so that the second portions 1206 are spread out over a deployed engagement member length L.
- the deployed engagement member length L may be between about 0.25 cm and about 3.0 cm, and in some embodiments, between about 0.5 cm and about 2 cm.
- the binding member 1210 can be a coil, spiral, tube, sleeve, braid and/or other generally suitable tubular configurations.
- the binding member 1210 may be slotted, cut or otherwise fenestrated to enhance flexibility.
- the binding member 1210 may be made of various metals, polymers and combinations thereof and may comprise materials visible under x-ray or fluoroscopy so as to function as a radiopaque marker to facilitate deployment, placement and retraction by the user.
- FIG. 10 is a side partial cross-sectional view of one embodiment of a delivery system 910 for delivering the clot treatment device 200 to a treatment site, such as the location of an embolism within a small blood vessel.
- the delivery system 910 can include a proximal portion 911 , an elongated delivery catheter 920 extending from a distal region of the proximal portion 911 , a delivery sheath 930 slidably received within a lumen of the delivery catheter 920 , and a tubular push member 940 slidably received within a lumen of the delivery sheath 930 . As shown in FIG.
- the clot treatment device 200 can be positioned within the delivery sheath 930 such that the delivery sheath 930 constrains the clot engagement members 202 in a low-profile delivery state that is generally parallel with the support member 204 .
- the delivery catheter 920 can have an outside diameter between about 0.08 mm and about 0.06 mm.
- a proximal portion of the support member 204 can be coupled to a distal region of the push member 204 such that axial movement of the push member 204 causes axial movement of the support member 204 (and thus the clot treatment device 200 ).
- the proximal portion 911 of the device can include a first hub 922 and a second hub 932 configured to be positioned external to the patient.
- the first and/or second hubs 922 , 932 can include a hemostatic adaptor, a Tuohy Borst adaptor, and/or other suitable valves and/or sealing devices.
- a distal region 920 a of the first hub 922 can be coupled to the delivery catheter 920 , and a proximal region of the first hub 922 can include an opening 924 configured to slidably receive the delivery sheath 930 therethrough.
- the first hub 922 can further include an aspiration line 926 coupled to a negative pressure-generating device 928 (shown schematically), such as a syringe or a vacuum pump.
- a negative pressure-generating device 928 shown schematically
- a distal region 932 a of the second hub 932 can be fixed to a proximal region of the delivery sheath 930 , and a proximal region of the second hub 932 can include an opening 934 configured to receive the push member 940 therethrough.
- the second hub 932 can include a port 936 configured to receive one or more fluids before, during and/or after the procedure (e.g., contrast, saline, etc.).
- the delivery system 910 does not include a guidewire.
- the inclusion of a guidewire increases the profile of the delivery catheter 920 and/or sheath 930 which is particularly undesirable for the treatment of small vessels.
- the clot treatment device 200 is configured to be delivered through a delivery catheter having a diameter less than or equal to 0.027 inches (e.g., less than an 0.021 inches, less than 0.015-0.018 inches.
- the delivery system can be configured to receive a guidewire and/or be delivered with the aid of a guidewire.
- FIGS. 11A-11K illustrate one example for treating a small vessel thromboembolism with the clot treatment device 200 (and delivery system 910 ).
- FIG. 11A is a side view of a delivery system 910 positioned adjacent to an embolism or clot material E within a small blood vessel V.
- Access to the target vessel can be achieved through the patient's vasculature, for example, via the femoral vein. It will be understood, however, that other access locations into the vasculature of a patient are possible and consistent with the present technology.
- the user can gain access through the jugular vein, the subclavian vein, the brachial vein or any other vein.
- Use of other vessels that are closer to the location of the embolism can also be advantageous as it reduces the length of the instruments needed to reach the embolism.
- the delivery sheath 930 containing the collapsed clot treatment device 200 can be advanced together with the delivery catheter 920 to the treatment site. and a distal portion of the delivery catheter 920 and/or delivery sheath 930 can be inserted through the embolism E such that the distal ends 201 of at least one group of the clot engagement members 202 are aligned with or positioned distal to a distal edge of the embolism E (as shown in FIG. 11B ).
- a distal portion of the delivery catheter 920 and/or delivery sheath 930 can be positioned such that the distal ends 201 of at least one group of the clot engagement members 202 are positioned proximal to a distal edge of the embolism E.
- the delivery catheter 930 can be pulled proximally to a position proximal of the embolism E (as shown in FIG. 11B ). As shown in FIGS. 11C-11G , the delivery sheath 930 can be retracted proximally to expose the distal portions of the second portions 208 of the clot engagement members such that the exposed portions radially expand and bend backwards in a proximal direction. As the second portions 208 expand, they extend into the embolism E around the device along an arcuate path P.
- the arcuate path P can extend radially outward and proximally with respect to the support member (not shown) and, as shown in FIG. 11F , can eventually curve radially inwardly.
- the second portions 208 can thus form hook-like capture elements that penetrate into and hold clot material to the device 200 for subsequent removal. Moreover, should the second portions 208 extend radially outwardly enough to touch the vessel wall, the end sections 214 of the second portions 208 form an atraumatic surface that can abut or apply pressure to the vessel wall without damaging the vessel wall.
- the device presents a plurality of arcuate members that may be substantially parallel with the axis of the device at the point of contact with the vessel wall when in the deployed state.
- the delivery sheath 930 when the delivery sheath 930 is withdrawn proximally beyond the second portions 208 of the most distal group of clot engagement members 202 f, the first portions 206 of the clot engagement members 202 f are exposed.
- the delivery sheath 930 can be withdrawn so as to expose only a portion of the clot engagement members. Additionally, in those embodiments having two or more groups of clot engagement members, the delivery sheath 930 can be withdrawn to expose all or some of the groups of clot engagement members. As shown in FIG.
- the delivery sheath 930 can continue to be withdrawn proximally to expose additional second portions 208 and/or groups of clot engagement members 202 a - f.
- Clot engagement members 202 a - f may just contact or be slightly deflected by the vessel wall. If the device is sized such that the diameter of the clot engagement members are larger than the vessel diameter (e.g., “over-sized”), the clot engagement members may be compressed by the vessel wall. Thus, while fully deployed, the device may be in state of a small amount of radial compression. In some embodiments, the device may be diametrically over-sized by between about 5% and 50% and in other embodiments between about 10% and 25%.
- the clot treatment device 200 can be withdrawn proximally, thereby pulling at least a portion of the clot material E in a proximal direction with the device 200 .
- the push member 940 , second hub 932 , and delivery sheath 930 can be retracted proximally at the same time and rate.
- the delivery catheter 920 can be held in place while the delivery sheath 930 , clot material E, and clot engagement device 200 are pulled proximally into the delivery catheter 920 .
- the curved shape of the second portions 208 increases the surface area of the clot engagement members 202 in contact with the clot material E, thus increasing the proximal forces exerted on the clot material. Withdrawal of the device 200 not only removes the clot but also can increase blood flow through the vessel.
- the delivery catheter 920 can include an aspiration lumen (not shown) configured to apply a negative pressure (indicated by arrows A) to facilitate removal of the clot material E.
- the delivery catheter 920 , delivery sheath 930 and/or clot treatment device 200 of the present technology can be configured to be operably coupled to the retraction and aspiration apparatus disclosed in Attorney Docket No. 111552.8004.US00, titled “Retraction and Aspiration Apparatus and Associated Systems and Methods,” filed concurrently herewith, which is incorporated herein by reference in its entirety.
- a negative pressure is applied at or near the distal portion of the delivery catheter 920 (via the aspiration lumen) only while the clot treatment device 200 and/or delivery sheath 930 is being retracted. Therefore, when retraction pauses or stops altogether, aspiration also pauses or stops altogether. Accordingly, aspiration is non-continuous and dependent upon retraction of the delivery sheath 930 and/or clot treatment device 200 .
- Such non-continuous, synchronized aspiration and retraction can be advantageous because it reduces the amount of fluid withdrawn from the patient's body during treatment (and thus less fluid need be replaced, if necessary).
Abstract
A device and method for intravascular treatment of an embolism, and particularly an embolism within a small vessel, is disclosed herein. One aspect of the present technology, for example, is directed toward a clot treatment device that includes a support member configured to extend through a delivery catheter and a plurality of clot engagement members positioned about the circumference of a distal portion of the support member. The individual clot engagement members can have a first portion and a second portion extending from the first portion, and the first portions can have a proximal region attached to the support member. In the deployed state, the individual second portions can extend from the distal region of one of the first portions and project radially outwardly relative to the support member in a curve that has a proximally extending section which defines a proximally facing concave portion.
Description
- The present application claims the benefit of U.S. Provisional Patent Application No. 61/949,953 filed Mar. 7, 2014, entitled “METHODS AND APPARATUS FOR TREATING EMBOLISM,” which is incorporated herein by reference in its entirety.
- The present technology relates generally to devices and methods for intravascular treatment of stroke, myocardial infarction and other small vessel thromboembolisms. Many embodiments of the technology relate to the intravascular removal of an embolism within a blood vessel associated with the brain, heart or peripheral vasculature.
- Thromboembolism occurs when a thrombus or blood clot trapped within a blood vessel breaks loose and travels through the blood stream to another location in the circulatory system, resulting in a clot or obstruction at the new location. Thromboembolisms in small blood vessels (such as those within the heart, brain, and peripheral vasculature) can be particularly difficult to treat intravascularly due to the limited space within the vessel at the target site.
- One indication caused by small vessel thromboembolisms is acute ischemic stroke, or the sudden loss of blood circulation to an area of the brain. As illustrated in
FIG. 1 , acute ischemic stroke is caused by a thrombus traveling through the brain and lodging in a cerebral artery, thereby causing thrombotic or embolic occlusion of the cerebral artery. Small vessel thromboembolisms can also lead to myocardial infarction (MI) or “heart attack”. An MI requires immediate medical attention. Treatment includes attempts to save as much viable heart muscle as possible and to prevent further complications. Small vessel thromboembolisms can also lead to peripheral vascular disease (PVD) and/or peripheral arterial disease (PAD). Conditions associated with PVD that affect the veins include deep vein thrombosis (DVT), varicose veins, and chronic venous insufficiency. Lymphedema is an example of PVD that affects the lymphatic vessel. Conditions associated with PAD may be occlusive (occurs because the artery becomes blocked in some manner) or functional (the artery either constricts due to a spasm or expands). Examples of occlusive PAD include peripheral arterial occlusion and Buerger's disease (thromboangiitis obliterans). Examples of functional PAD include Raynaud's disease and phenomenon and acrocyanosis. - Conventional approaches to treating thromboembolism in small vessels include clot reduction and/or removal. For example, anticoagulants can be introduced to the affected vessel to prevent additional clots from forming, and thrombolytics can be introduced to the vessel to at least partially disintegrate the clot. However, such agents typically take a prolonged period of time (e.g., hours, days, etc.) before the treatment is effective and in some instances can cause bleeding complications including major bleeding and intracranial hemorrhaging. Transcatheter clot removal devices also exist, however, such devices are typically highly complex, prone to cause trauma to the vessel, hard to navigate to the embolism site, and/or expensive to manufacture. Conventional approaches also include surgical techniques that involve opening the chest cavity and dissecting the vessel. Such surgical procedures, however, come with increased cost, procedure time, risk of infection, higher morbidity, higher mortality, and recovery time. Accordingly, there is a need for devices and methods that address one or more of these deficiencies.
- Many aspects of the present technology can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale. Instead, emphasis is placed on illustrating clearly the principles of the present disclosure.
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FIG. 1 is a schematic illustration of an embolism traveling through the brain and forming an embolism in a cerebral blood vessel. -
FIG. 2A is a perspective view of one embodiment of a clot treatment device in a collapsed or delivery state configured in accordance with an embodiment of the present technology. -
FIG. 2B is a perspective view of the clot treatment device ofFIG. 2A in a deployed state configured in accordance with an embodiment of the present technology. -
FIG. 2C is an enlarged view of a portion the clot treatment device shown inFIG. 2A . -
FIG. 2D is an axial-perspective view of a portion of the clot treatment device shown inFIG. 2A . -
FIGS. 3A-3C are isolated, enlarged side views of clot engagement members in a deployed state configured in accordance with embodiments of the present technology. -
FIG. 4A is a perspective view of another embodiment of a clot treatment device in a collapsed or delivery state configured in accordance with an embodiment of the present technology. -
FIG. 4B is a perspective view of the clot treatment device ofFIG. 4A in a deployed state configured in accordance with an embodiment of the present technology. -
FIG. 5 is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology. -
FIG. 6 is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology. -
FIG. 7A is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology. -
FIG. 7B is a cross-sectional end view taken alongline 7B-7B inFIG. 7A . -
FIG. 8 is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology. -
FIG. 9A is a perspective view of a clot treatment device configured in accordance with another embodiment of the present technology. -
FIG. 9B is a cross-sectional end view of a portion of the clot treatment device shown inFIG. 9A . -
FIG. 9C is a side view of a binding member configured in accordance with the present technology. -
FIG. 10 is a side partial cross-sectional view of a delivery system configured in accordance an embodiment of the present technology. -
FIGS. 11A-11K illustrate a method for using a clot treatment device configured in accordance with the present technology to remove clot material from a vessel. - Specific details of several embodiments of clot treatment devices, systems and associated methods in accordance with the present technology are described below with reference to
FIGS. 2A-11K . Although many of the embodiments are described below with respect to devices, systems, and methods for treating small vessel thromboemboli within the heart, brain and peripheral vasculature, other applications and other embodiments in addition to those described herein are within the scope of the technology (for example, small vessels in other parts of the vasculature). As used herein, “small vessel” refers to any portion of the vasculature having an inner diameter less than about 6 mm. Additionally, several other embodiments of the technology can have different states, components, or procedures than those described herein. Moreover, it will be appreciated that specific elements, substructures, advantages, uses, and/or other features of the embodiments described with reference toFIGS. 2A-11K can be suitably interchanged, substituted or otherwise configured with one another in accordance with additional embodiments of the present technology. Furthermore, suitable elements of the embodiments described with reference toFIGS. 2A-11K can be used as standalone and/or self-contained devices. A person of ordinary skill in the art, therefore, will accordingly understand that the technology can have other embodiments with additional elements, or the technology can have other embodiments without several of the features shown and described below with reference toFIGS. 2A-11K . - With regard to the terms “distal” and “proximal” within this description, unless otherwise specified, the terms can reference a relative position of the portions of a clot treatment device and/or an associated delivery device with reference to an operator and/or a location in the vasculature.
- I. Selected Embodiments of Clot Treatment Devices
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FIG. 2A is a perspective view of one embodiment of a clot treatment device 200 (“thedevice 200”) in a low-profile or delivery state, andFIG. 2B is a perspective view of thedevice 200 in an unrestricted expanded or deployed state that is well suited for removing clot material from a small blood vessel (e.g., a cerebral blood vessel). Referring toFIGS. 2A and 2B together, thedevice 200 can include asupport member 204 and a plurality ofclot engagement members 202 positioned about the circumference of thesupport member 204. As best shown inFIG. 2B , the individualclot engagement members 202 can include afirst portion 206 having aproximal region 205 and adistal region 207, and asecond portion 208 extending from thedistal region 207 of thefirst portion 206. In the delivery state, as shown inFIG. 2A , theclot engagement members 202 can be generally linear and extend generally parallel to thesupport member 204. In the expanded state, as shown inFIG. 2B , thesecond portions 208 can project radially outwardly relative to thesupport member 204 in a curved shape. Thesecond portions 208 can have aproximally facing section 212 which defines a proximally facing concave portion, and, in some embodiments, thesecond portions 208 can further include anend section 214 that curves radially inwardly from theproximally facing section 212. When deployed within a blood vessel adjacent to clot material, theclot engagement members 202 are configured to penetrate the clot material along an arcuate path and hold clot material to thedevice 200, as discussed in greater detail below with reference toFIGS. 10-11K . -
FIG. 2C is an enlarged view of a portion of thedevice 200 ofFIG. 2A showing that thedevice 200 can include ahub 210 that couples theproximal regions 205 of thefirst portions 206 to thesupport member 204. Thefirst portions 206 can extend distally from theirproximal regions 205 in a longitudinal direction along the length of thesupport member 204 to theirdistal regions 207, and thedistal regions 207 can be free to move relative to thesupport member 204. As such, thefirst portions 206 can be cantilevered portions of theclot engagement members 202 that enable theclot engagement members 202 to flex and move independently of thesupport member 204 in response to forces present within the blood vessel, such as blood flow, gravity, and/or the local anatomy. Thefirst portions 206 can be sufficiently rigid to maintain a generally linear shape along their respective lengths, yet flexible enough to bend and/or flex about thehub 210. For example, in some instances, in response to local forces, one or more of thedistal regions 207 of thefirst portions 206 can be spaced radially apart from thesupport member 204 such that one or morefirst portions 206 forms an angle with thesupport member 204. - Referring back to
FIGS. 2A and 2B , thefirst portions 206 of differentclot engagement members 202 can have different lengths such that thesecond portions 208 of at least two clot engagement members extend radially outwardly at different locations along the length of thesupport member 204. For example, as best shown inFIG. 2B , theclot treatment device 200 can include afirst group 202 a ofclot engagement members 202 havingfirst portions 206 with a first length L1, asecond group 202 b ofclot engagement members 202 havingfirst portions 206 with a second length L2 greater than the first length L1, a third group ofclot engagement members 202 c havingfirst portions 206 with a third length L3 greater than the second length L2, a fourth group ofclot engagement members 202 d havingfirst portions 206 with a fourth length L4 greater than the third length L3, a fifth group ofclot engagement members 202 e havingfirst portions 206 with a fifth length L5 greater than the fourth length L4, and a sixth group ofclot engagement members 202 f havingfirst portions 206 with a sixth length L6 greater than the fifth length L5. It will be appreciated that although six groups of clot engagement members are shown inFIGS. 2A and 2B , in other embodiments the clot treatment device can have more or fewer than six groups (e.g., one group, two groups, three groups, seven groups, ten groups, etc.) and/or the lengths of all or some of thefirst portions 206 can be the same or different. - Moreover, the
second portions 208 of thefirst group 202 a ofclot engagement members 202 extend radially outward at a first area of thesupport member 204, thesecond portions 208 of thesecond group 202 b of theclot engagement members 202 extend radially outward from a second area of thesupport member 204, thesecond portions 208 of thethird group 202 c ofclot engagement members 202 extend radially outward from a third area of thesupport member 204, thesecond portions 208 of thefourth group 202 d ofclot engagement members 202 extend radially outward from a fourth area of thesupport member 204, thesecond portions 208 of thefifth group 202 e ofclot engagement members 202 extend radially outward from a fifth area of thesupport member 204, and thesecond portions 208 of thesixth group 202 f ofclot engagement members 202 extend radially outward from a sixth area of thesupport member 204. It will be appreciated that although six areas of clot engagement members are shown inFIGS. 2A and 2B , in other embodiments the clot treatment device can have more or fewer than six areas (e.g., one area, two areas, three areas, five areas, nine areas, etc.). -
FIG. 2D is an enlarged, axial-perspective view of a portion of thedevice 200 in which the groups ofclot engagement members 202 a-f (only the first, second andthird groups 202 a-c shown) are arranged about the circumference of thesupport member 204 such that the second portions (labeled 208 a-c) ofadjacent groups 202 a-c are circumferentially offset from one another. As such, in the embodiment shown inFIG. 2D , thesecond portions 208 of adjacent groups ofclot engagement members 202 a-f are not circumferentially aligned, and thus can engage the clot material at different circumferential positions along the length of the clot material. -
FIG. 3A is a side view of aclot engagement member 202 in the expanded state. Individual clot engagement members can be made from a shape memory material such that, when unconstrained, assume a preformed curved shape. As shown inFIG. 3A , thesecond portion 208 can have an arcuate shape that includes an outwardly extendingsection 216, theproximally facing section 212 extending from the outwardly extendingsection 216, and theend section 214 extending from theproximally facing section 212. In one embodiment, the demarcation between theproximally facing section 212 and theend section 214 occurs at an apex 218 of thesecond portion 208. Theproximally facing section 212 is configured to retain clot material with theclot engagement member 202 as thedevice 200 is pulled proximally through the vessel (arrow P), and the apex 218 provides a smooth curve that can atraumatically slide along the vessel wall as thedevice 200 is pulled proximally through the vessel. In the embodiment shown inFIG. 3A , thesecond portion 208 of theclot treatment device 200 can have a single or constant radius of curvature R1. In other embodiments, such as theclot engagement member 402 shown inFIG. 3B , thesecond portions 208 can have a plurality of radii of curvature, such as a first region with a first radius of curvature R1 and a second region with a second radius of curvature R2. In the embodiment shown inFIGS. 2A-2D , thesecond portions 208 of theclot engagement members 202 have a single radius of curvature that is the same for all of theclot engagement members 202. In other embodiments, thedevice 200 can have a first group of second portions with a constant radius of curvature and a second group of second portions with a plurality of radii of curvature. Moreover, in additional embodiments thedevice 200 can include a first group of second portions having a first radius of curvature and a second group of second portions having a second radius of curvature different than the first radius of curvature. In some embodiments, the radius R1 of theclot engagement members 202 can be between about 0.15 mm and about 3 mm, and in some embodiments, between about 0.25 mm and about 2 mm. - As shown in
FIG. 3C , the arc length a of theclot engagement members 202 may be substantially greater than 180 degrees to provide several benefits in performance of clot engagement and retrieval. In particular, a greater arc length a can provide improved clot engagement during retraction when resistance due to clot friction and interference with the vessel wall deflects theclot engagement member 202 distally (arrow D). A greater arc length a may provide more deflection and/or unravelling or straightening of the arcuate shape without loss of engagement with the clot. In some embodiments, the arc length a of theclot engagement members 202 can be greater than about 200 degrees. In some embodiments the arc length a of theclot engagement members 202 may be between about 200 degrees and 340 degrees and between about 240 degrees and 300 degrees in other embodiments. It can be advantageous to keep the arc length a under about 360 degrees so as to avoid overlap of theclot engagement member 202. Greater arc length a can allow for the use of smaller clot engagement member filaments or wires that may be particularly beneficial for minimization of the collapsed profile of the device. Greater arc length a can also allow for a larger total number ofclot engagement members 202 that also enhance the ability of the device to remove embolic material from a small vessel. Moreover, in some embodiments, the distal end of theclot engagement members 202 may define an angle with respect to the axis of the support member and/or the straight portion of the engagement members (as shown inFIG. 3C ). This angle may be between about 30 degrees and about 90 degrees, and in some embodiments between about 40 degrees and about 80 degrees. - The
clot engagement members 202 can be made from a variety of materials. In a particular embodiment, theclot engagement members 202 comprise a material with sufficient elasticity to allow for repeated collapse into an appropriately sized catheter and full deployment in a blood vessel. Such suitable metals can include nickel-titanium alloys (e.g., Nitinol), platinum, cobalt-chrome alloys, Elgiloy, stainless steel, tungsten, titanium and/or others. Polymers and metal/polymer composites can also be utilized in the construction of the clot engagement members. Polymer materials can include Dacron, polyester, polyethylene, polypropylene, nylon, Teflon, PTFE, ePTFE, TFE, PET, TPE, PLA silicone, polyurethane, polyethylene, ABS, polycarbonate, styrene, polyimide, PEBAX, Hytrel, polyvinyl chloride, HDPE, LDPE, PEEK, rubber, latex and the like. In some embodiments, theclot engagement members 202 may comprise an environmentally responsive material, also known as a smart material. Smart materials are designed materials that have one or more properties that can be significantly changed in a controlled fashion by external stimuli, such as stress, temperature, moisture, pH, electric or magnetic fields. - In some embodiments, portions of the exterior surfaces of the
support member 204 and/orclot engagement members 202 may be textured, or the exterior surfaces can include microfeatures configured to facilitate engagement or adhesion of thrombus material (e.g., ridges, bumps, protrusions, grooves, cut-outs, recesses, serrations, etc.). In some embodiments, theclot engagement members 202 may be coated with one or more materials to promote platelet activation or adhesion of thrombus material. Adhesion of thrombi toclot engagement members 202 may facilitate capture and/or removal. - In some embodiments, the
clot treatment device 200 can include between about 20 and about 140clot engagement members 202, and in some embodiments, between about 40 and about 120clot engagement members 202. Theclot engagement members 202 can individually have one consistent diameter or have a variety of diameters (among the members 202) along their lengths. In addition, an individualclot engagement member 202 may have a tapered or varying diameter along its length to provide desired mechanical characteristics. The average diameter of theclot engagement members 202 can be between about 0.02 mm to about 0.1 mm in some embodiments and in a particular embodiment, between about 0.04 mm and 0.08 mm. - In any of the embodiments described herein, the
clot engagement members 202 can be formed from a filament or wire having a circular cross-section. Additionally, theclot engagement members 202 can be formed from a filament or wire having a non-circular cross-section. For example, filaments or wires having square, rectangular and oval cross-sections may be used. In some embodiments, a rectangular wire (also known as a “flat wire”) may have a height or radial dimension of between about 0.02 mm to about 0.1 mm. In some embodiments, a rectangular wire may have a width or transverse dimension of between about 0.02 mm to about 0.08 mm. In some embodiments, a rectangular wire may have a height to width ratio of between about 0.3 to about 0.9 and between about 1 and about 1.8. -
FIGS. 4A and 4B illustrate an embodiment in which clot engagement members having non-circular cross-sections can be fabricated from a tube (e.g., a hypotube). The tube may be cut or machined by various means known in the art including conventional machining, laser cutting, electrical discharge machining (EDM) or photochemical machining (PCM). Referring toFIG. 4A , a tube may be cut to form a plurality ofclot engagement members 454 that are integral with ahub member 456. The cut tube may then be formed by heat treatment to move from a delivery state shown inFIG. 4A to a deployed state shown inFIG. 4B in which an array of arcuateclot engagement members 454 project radially outward. As is known in the art of heat setting, a fixture or mold may be used to hold the structure in its desired final configuration and subjected to an appropriate heat treatment such that the clot engagement members assume or are otherwise shape-set to the desire arcuate shape. In some embodiments, the device or component may be held by a fixture and heated to about 475-525° C. for about 5-15 minutes to shape-set the structure. In some embodiments, the tubular clot engagement structure may be formed from various metals or alloys such as Nitinol, platinum, cobalt-chrome alloys, 35N LT, Elgiloy, stainless steel, tungsten or titanium. -
FIG. 5 is a perspective view of another embodiment of aclot treatment device 500 in a deployed state in accordance with the present technology. As shown inFIG. 5 , theclot treatment device 500 can include a plurality of clot engagement members 502 generally similar to theclot engagement members FIGS. 2A-4B , except the clot engagement members 502 ofFIG. 5 are arranged about thesupport member 204 such that the length of thefirst portions 506 increase in a clockwise or counterclockwise direction about 360 degrees of thesupport member 204. As such, thesecond portions 508 spiral around the length of thesupport member 204 and each successivesecond portion 508 extending from a location along the shaft that is circumferentially offset and distal to the location of the immediately adjacentsecond portion 508. -
FIG. 6 is a perspective view of another embodiment of aclot treatment device 600 in a deployed state in accordance with the present technology. Theclot treatment device 600 can include a plurality ofclot engagement members 602 generally similar to theclot engagement members FIGS. 2A-4B , except thesecond portions 608 of theclot engagement members 602 ofFIG. 6 are not arranged in groups, but instead extend at irregular intervals fromsupport member 204. -
FIG. 7A is a perspective view of another embodiment of aclot treatment device 700 in a deployed state in accordance with the present technology, andFIG. 7B is a cross-sectional end view taken alongline 7B-7B inFIG. 7A . Referring toFIGS. 7A and 7B together, theclot treatment device 700 can have groups of clot engagement members 702 a-f spaced along thesupport member 204. The groups 702 a-f can include a plurality of arcuate clot engagement members 702 generally similar to theclot engagement members FIGS. 2A-4B , except thesecond portions 708 of the clot engagement members 702 ofFIG. 7A extend at an angle from thesupport member 204 such that the distal ends 713 of thesecond portions 708 are not circumferentially aligned with the corresponding proximal ends 711 of thesecond portions 708. For example, as shown inFIG. 7B , thesecond portions 708 can extend at an angle θ from thefirst portions 706. In some embodiments, the angle θ can be between about 10 and about 80 degrees. In a particular embodiment, the angle θ can be between about 40 and about 60 degrees. Additionally, as shown inFIGS. 4B and 7B , the clot engagement members may form a substantially circular axial array about the axis of the support member. A circular array may engage clot more uniformly and securely than a non-circular array and thus may facilitate retrieval and removal of clot from the vessel. -
FIG. 8 is a perspective view of another embodiment of aclot treatment device 800 in a deployed state in accordance with the present technology. As shown inFIG. 8 , theclot treatment device 800 can have groups ofclot engagement members 802 a-f spaced along thesupport member 204. Thegroups 802 a-f can include a plurality of arcuateclot engagement members 802 generally similar to theclot engagement members FIGS. 2A-4B , except theclot engagement members 802 ofFIG. 8 do not include a first or cantilevered portion. As such, theclot engagement members 802 include only a curvedsecond portion 808 which is coupled to thesupport member 204 at one end (e.g., via hubs 810 a-f). In other embodiments, however, theclot engagement members 802 can have relatively short first portions (e.g., less than about 10 mm (e.g., less than about 5 mm, less than about 3 mm, less than about 2 mm, etc.)). In some embodiments, thegroups 802 a-f can be evenly spaced along thesupport member 204, and in other embodiments thegroups 802 a-f can have any spacing or state along thesupport member 204. Additionally, the arcuateclot engagement members 802 at onegroup 802 can have a different size than the arcuateclot engagement members 802 at adifferent group 802. Thegroups 802 a-f can be deployed or expanded simultaneously (e.g., via a push-wire or other deployment methods) or consecutively (e.g., by retracting a sheath). -
FIG. 9A is a perspective view of another embodiment of aclot treatment device 1200 in a deployed state configured in accordance with the present technology. In some embodiments, thedevice 1200 can include a plurality ofclot engagement members 1202 arranged in closely-packed circular array. Theclot engagement members 1202 can be generally similar to theclot engagement members FIGS. 2A-4B . A proximal portion of theclot engagement members 1202 can be bound together and surrounded by a tubular bindingmember 1210. Theclot engagement members 1202 can fill substantially all of a lumen of the bindingmember 1210, as shown in the cross-sectional view ofFIG. 9B (other than the small gaps between the clot engagement members (that are too small for another clot engagement member)). Referring toFIG. 9A , theclot engagement members 1202 can havefirst portions 1206 with differing lengths so that thesecond portions 1206 are spread out over a deployed engagement member length L. In some embodiments, the deployed engagement member length L may be between about 0.25 cm and about 3.0 cm, and in some embodiments, between about 0.5 cm and about 2 cm. As shown inFIG. 9C , the bindingmember 1210 can be a coil, spiral, tube, sleeve, braid and/or other generally suitable tubular configurations. The bindingmember 1210 may be slotted, cut or otherwise fenestrated to enhance flexibility. The bindingmember 1210 may be made of various metals, polymers and combinations thereof and may comprise materials visible under x-ray or fluoroscopy so as to function as a radiopaque marker to facilitate deployment, placement and retraction by the user. - II. Delivery Systems and Methods
-
FIG. 10 is a side partial cross-sectional view of one embodiment of adelivery system 910 for delivering theclot treatment device 200 to a treatment site, such as the location of an embolism within a small blood vessel. Thedelivery system 910 can include aproximal portion 911, anelongated delivery catheter 920 extending from a distal region of theproximal portion 911, adelivery sheath 930 slidably received within a lumen of thedelivery catheter 920, and atubular push member 940 slidably received within a lumen of thedelivery sheath 930. As shown inFIG. 10 , theclot treatment device 200 can be positioned within thedelivery sheath 930 such that thedelivery sheath 930 constrains theclot engagement members 202 in a low-profile delivery state that is generally parallel with thesupport member 204. In some embodiments, thedelivery catheter 920 can have an outside diameter between about 0.08 mm and about 0.06 mm. A proximal portion of thesupport member 204 can be coupled to a distal region of thepush member 204 such that axial movement of thepush member 204 causes axial movement of the support member 204 (and thus the clot treatment device 200). - The
proximal portion 911 of the device can include afirst hub 922 and asecond hub 932 configured to be positioned external to the patient. The first and/orsecond hubs distal region 920 a of thefirst hub 922 can be coupled to thedelivery catheter 920, and a proximal region of thefirst hub 922 can include anopening 924 configured to slidably receive thedelivery sheath 930 therethrough. In some embodiments, thefirst hub 922 can further include anaspiration line 926 coupled to a negative pressure-generating device 928 (shown schematically), such as a syringe or a vacuum pump. A distal region 932 a of thesecond hub 932 can be fixed to a proximal region of thedelivery sheath 930, and a proximal region of thesecond hub 932 can include anopening 934 configured to receive thepush member 940 therethrough. Additionally, in some embodiments, thesecond hub 932 can include aport 936 configured to receive one or more fluids before, during and/or after the procedure (e.g., contrast, saline, etc.). - As shown in
FIG. 10 , thedelivery system 910 does not include a guidewire. The inclusion of a guidewire increases the profile of thedelivery catheter 920 and/orsheath 930 which is particularly undesirable for the treatment of small vessels. Several conventional microcatheters exist that do not require a guidewire and can be used with the any of the clot treatment device embodiments disclosed herein, such as Progreat™ by Terumo Interventional Systems and Prowler® Microcatheter by DePuy Synthes. In some embodiments, for example, for delivery to a cerebral blood vessel (e.g., to treat stroke), theclot treatment device 200 is configured to be delivered through a delivery catheter having a diameter less than or equal to 0.027 inches (e.g., less than an 0.021 inches, less than 0.015-0.018 inches. In other embodiments, however, the delivery system can be configured to receive a guidewire and/or be delivered with the aid of a guidewire. -
FIGS. 11A-11K illustrate one example for treating a small vessel thromboembolism with the clot treatment device 200 (and delivery system 910).FIG. 11A is a side view of adelivery system 910 positioned adjacent to an embolism or clot material E within a small blood vessel V. Access to the target vessel can be achieved through the patient's vasculature, for example, via the femoral vein. It will be understood, however, that other access locations into the vasculature of a patient are possible and consistent with the present technology. For example, the user can gain access through the jugular vein, the subclavian vein, the brachial vein or any other vein. Use of other vessels that are closer to the location of the embolism can also be advantageous as it reduces the length of the instruments needed to reach the embolism. - As shown in
FIG. 11A , thedelivery sheath 930 containing the collapsed clot treatment device 200 (not shown) can be advanced together with thedelivery catheter 920 to the treatment site. and a distal portion of thedelivery catheter 920 and/ordelivery sheath 930 can be inserted through the embolism E such that the distal ends 201 of at least one group of theclot engagement members 202 are aligned with or positioned distal to a distal edge of the embolism E (as shown inFIG. 11B ). In other embodiments (not shown), a distal portion of thedelivery catheter 920 and/ordelivery sheath 930 can be positioned such that the distal ends 201 of at least one group of theclot engagement members 202 are positioned proximal to a distal edge of the embolism E. - Once the device is positioned, the
delivery catheter 930 can be pulled proximally to a position proximal of the embolism E (as shown inFIG. 11B ). As shown inFIGS. 11C-11G , thedelivery sheath 930 can be retracted proximally to expose the distal portions of thesecond portions 208 of the clot engagement members such that the exposed portions radially expand and bend backwards in a proximal direction. As thesecond portions 208 expand, they extend into the embolism E around the device along an arcuate path P. The arcuate path P can extend radially outward and proximally with respect to the support member (not shown) and, as shown inFIG. 11F , can eventually curve radially inwardly. Thesecond portions 208 can thus form hook-like capture elements that penetrate into and hold clot material to thedevice 200 for subsequent removal. Moreover, should thesecond portions 208 extend radially outwardly enough to touch the vessel wall, theend sections 214 of thesecond portions 208 form an atraumatic surface that can abut or apply pressure to the vessel wall without damaging the vessel wall. In some embodiments, the device presents a plurality of arcuate members that may be substantially parallel with the axis of the device at the point of contact with the vessel wall when in the deployed state. - Still referring to
FIG. 11F , when thedelivery sheath 930 is withdrawn proximally beyond thesecond portions 208 of the most distal group ofclot engagement members 202 f, thefirst portions 206 of theclot engagement members 202 f are exposed. In some embodiments, thedelivery sheath 930 can be withdrawn so as to expose only a portion of the clot engagement members. Additionally, in those embodiments having two or more groups of clot engagement members, thedelivery sheath 930 can be withdrawn to expose all or some of the groups of clot engagement members. As shown inFIG. 11G , thedelivery sheath 930 can continue to be withdrawn proximally to expose additionalsecond portions 208 and/or groups ofclot engagement members 202 a-f.Clot engagement members 202 a-f may just contact or be slightly deflected by the vessel wall. If the device is sized such that the diameter of the clot engagement members are larger than the vessel diameter (e.g., “over-sized”), the clot engagement members may be compressed by the vessel wall. Thus, while fully deployed, the device may be in state of a small amount of radial compression. In some embodiments, the device may be diametrically over-sized by between about 5% and 50% and in other embodiments between about 10% and 25%. - As shown in
FIGS. 11H-11K , once at least a portion of the clot engagement members and/orsecond portions 208 have penetrated and engaged the targeted clot material E, theclot treatment device 200 can be withdrawn proximally, thereby pulling at least a portion of the clot material E in a proximal direction with thedevice 200. For example, thepush member 940,second hub 932, and delivery sheath 930 (FIG. 10 ) can be retracted proximally at the same time and rate. As such, thedelivery catheter 920 can be held in place while thedelivery sheath 930, clot material E, andclot engagement device 200 are pulled proximally into thedelivery catheter 920. The curved shape of thesecond portions 208 increases the surface area of theclot engagement members 202 in contact with the clot material E, thus increasing the proximal forces exerted on the clot material. Withdrawal of thedevice 200 not only removes the clot but also can increase blood flow through the vessel. - As shown in
FIG. 11K , in some embodiments thedelivery catheter 920 can include an aspiration lumen (not shown) configured to apply a negative pressure (indicated by arrows A) to facilitate removal of the clot material E. For example, thedelivery catheter 920,delivery sheath 930 and/orclot treatment device 200 of the present technology can be configured to be operably coupled to the retraction and aspiration apparatus disclosed in Attorney Docket No. 111552.8004.US00, titled “Retraction and Aspiration Apparatus and Associated Systems and Methods,” filed concurrently herewith, which is incorporated herein by reference in its entirety. When coupled to the retraction and aspiration apparatus, a negative pressure is applied at or near the distal portion of the delivery catheter 920 (via the aspiration lumen) only while theclot treatment device 200 and/ordelivery sheath 930 is being retracted. Therefore, when retraction pauses or stops altogether, aspiration also pauses or stops altogether. Accordingly, aspiration is non-continuous and dependent upon retraction of thedelivery sheath 930 and/orclot treatment device 200. Such non-continuous, synchronized aspiration and retraction can be advantageous because it reduces the amount of fluid withdrawn from the patient's body during treatment (and thus less fluid need be replaced, if necessary). In addition, it may be advantageous to consolidate the steps and motions required to both mechanically transport the thrombus into the guide catheter (e.g. aspiration tube) and remove fluid from the tube into one motion, by one person. - Although the invention has been described in terms of particular embodiments and applications, one of ordinary skill in the art, in light of this teaching, can generate additional embodiments and modifications without departing from the spirit of or exceeding the scope of the exampled invention. Accordingly, it is to be understood that the drawings and descriptions herein are proffered by way of example to facilitate comprehension of the invention and should not be construed to limit the scope thereof.
Claims (11)
1-20. (canceled)
21. A method of treating a cerebral or coronary embolism that at least partially restricts blood flow through a small vessel, the method comprising:
deploying an embolectomy device within the embolism in the small vessel by penetrating clot material with a plurality of clot engagement members, wherein individual clot engagement members extend into the clot material along an arcuate path that extends radially outward and proximally with respect to the elongated shaft, and then curve radially inwardly, whereby the clot material is held by the clot engagement members;
moving the embolectomy device and at least a portion of the embolism along the small vessel; and
withdrawing the embolectomy device and at least a portion of the embolism from the small vessel.
22. The method of claim 21 wherein deploying the embolectomy device comprises expanding the clot engagement members into arcuate shapes, each having a concave portion facing proximally.
23. The method of claim 21 wherein withdrawing the embolectomy device comprises urging the portion of the embolism into a catheter while applying a vacuum through the catheter.
24. The method of claim 21 wherein retraction of the device includes extracting at least some clot material and increasing flow in the small vessel where flow had been reduced by the presence of a thrombus.
25. The method of claim 21 wherein individual clot engagement members have a first portion and a second portion extending from the first portion, and wherein individual first portions have a proximal region attached to the support member and a distal region, and wherein the first portions extend distally in a longitudinal direction from the proximal region to the distal region.
26. The method of claim 25 wherein individual second portions further include an end section curving radially inward from the proximally extending section.
27. The method of claim 25 wherein individual clot engagement members have a proximal region that is fixed to a distal portion of the embolectomy device.
28. The method of claim 21 , further comprising improving blood flow to ischemic tissue.
29. The method of claim 21 , wherein the small vessel is a cerebral vessel.
30. The method of claim 21 , wherein the small vessel is a coronary vessel.
Priority Applications (6)
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US14/299,997 US20150018860A1 (en) | 2013-07-12 | 2014-06-09 | Methods and apparatus for treating small vessel thromboembolisms |
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US15/031,102 US10238406B2 (en) | 2013-10-21 | 2014-10-21 | Methods and apparatus for treating embolism |
US14/639,890 US20150374391A1 (en) | 2014-03-07 | 2015-03-05 | Methods and apparatus for treating small vessel thromboembolisms |
US16/224,193 US11058445B2 (en) | 2013-10-21 | 2018-12-18 | Methods and apparatus for treating embolism |
US17/357,817 US11937838B2 (en) | 2013-10-21 | 2021-06-24 | Methods and apparatus for treating embolism |
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US14/299,997 US20150018860A1 (en) | 2013-07-12 | 2014-06-09 | Methods and apparatus for treating small vessel thromboembolisms |
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US14/639,890 Continuation US20150374391A1 (en) | 2014-03-07 | 2015-03-05 | Methods and apparatus for treating small vessel thromboembolisms |
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Cited By (70)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9351749B2 (en) | 2010-10-22 | 2016-05-31 | Neuravi Limited | Clot engagement and removal system |
US9402707B2 (en) | 2008-07-22 | 2016-08-02 | Neuravi Limited | Clot capture systems and associated methods |
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US9445829B2 (en) | 2013-03-14 | 2016-09-20 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
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WO2017072761A1 (en) * | 2015-10-26 | 2017-05-04 | Amnis Therapeutics Ltd. | Systems for thrombectomy |
US9642635B2 (en) | 2013-03-13 | 2017-05-09 | Neuravi Limited | Clot removal device |
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US9717519B2 (en) | 2012-11-20 | 2017-08-01 | Inceptus Medical, Llc | Methods and apparatus for treating embolism |
US20170303942A1 (en) * | 2016-04-25 | 2017-10-26 | Stryker Corporation | Pre-loaded inverting tractor thrombectomy apparatuses and methods |
US9994980B2 (en) | 2016-10-14 | 2018-06-12 | Inceptus Medical, Llc | Braiding machine and methods of use |
US10028759B2 (en) | 2016-04-25 | 2018-07-24 | Stryker Corporation | Anti-jamming and macerating thrombectomy apparatuses and methods |
US10045790B2 (en) | 2012-09-24 | 2018-08-14 | Inari Medical, Inc. | Device and method for treating vascular occlusion |
US10201360B2 (en) | 2013-03-14 | 2019-02-12 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US10238406B2 (en) | 2013-10-21 | 2019-03-26 | Inari Medical, Inc. | Methods and apparatus for treating embolism |
US10265086B2 (en) | 2014-06-30 | 2019-04-23 | Neuravi Limited | System for removing a clot from a blood vessel |
US10285720B2 (en) | 2014-03-11 | 2019-05-14 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US10342571B2 (en) | 2015-10-23 | 2019-07-09 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
US10363054B2 (en) | 2014-11-26 | 2019-07-30 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US10376267B2 (en) | 2017-02-24 | 2019-08-13 | Inceptus Medical, Llc | Vascular occlusion devices and methods |
US10441301B2 (en) | 2014-06-13 | 2019-10-15 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US10517624B2 (en) | 2016-06-03 | 2019-12-31 | Stryker Corporation | Inverting thrombectomy apparatuses and methods |
US10524811B2 (en) | 2015-10-23 | 2020-01-07 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
US10610245B2 (en) | 2016-09-12 | 2020-04-07 | Stryker Corporation | Self-rolling thrombectomy apparatuses and methods |
US10617435B2 (en) | 2014-11-26 | 2020-04-14 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10779843B2 (en) | 2017-11-09 | 2020-09-22 | Stryker Corporation | Inverting thrombectomy apparatuses having enhanced tracking |
US10792056B2 (en) | 2014-06-13 | 2020-10-06 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
US10835269B1 (en) | 2018-09-10 | 2020-11-17 | Stryker Corporation | Inverting thrombectomy apparatuses and methods of use |
US10842513B2 (en) | 2016-04-25 | 2020-11-24 | Stryker Corporation | Methods for advancing inverting mechanical thrombectomy apparatuses in the vasculature |
US10842498B2 (en) | 2018-09-13 | 2020-11-24 | Neuravi Limited | Systems and methods of restoring perfusion to a vessel |
US10912577B2 (en) | 2017-01-10 | 2021-02-09 | Inari Medical, Inc. | Devices and methods for treating vascular occlusion |
US11000682B2 (en) | 2017-09-06 | 2021-05-11 | Inari Medical, Inc. | Hemostasis valves and methods of use |
US11103265B2 (en) | 2018-05-14 | 2021-08-31 | Stryker Corporation | Inverting thrombectomy apparatuses and methods of use |
US11147572B2 (en) | 2016-09-06 | 2021-10-19 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US11154314B2 (en) | 2018-01-26 | 2021-10-26 | Inari Medical, Inc. | Single insertion delivery system for treating embolism and associated systems and methods |
US11253291B2 (en) | 2018-09-10 | 2022-02-22 | Stryker Corporation | Laser slotted grabbing device |
US11253278B2 (en) | 2014-11-26 | 2022-02-22 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US11259824B2 (en) | 2011-03-09 | 2022-03-01 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
US11311304B2 (en) | 2019-03-04 | 2022-04-26 | Neuravi Limited | Actuated clot retrieval catheter |
US11395669B2 (en) | 2020-06-23 | 2022-07-26 | Neuravi Limited | Clot retrieval device with flexible collapsible frame |
US11395667B2 (en) | 2016-08-17 | 2022-07-26 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US11406416B2 (en) | 2018-10-02 | 2022-08-09 | Neuravi Limited | Joint assembly for vasculature obstruction capture device |
US11433218B2 (en) | 2015-12-18 | 2022-09-06 | Inari Medical, Inc. | Catheter shaft and associated devices, systems, and methods |
US11439418B2 (en) | 2020-06-23 | 2022-09-13 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11497512B2 (en) | 2016-04-25 | 2022-11-15 | Stryker Corporation | Inverting thrombectomy apparatuses and methods |
US11517340B2 (en) | 2019-12-03 | 2022-12-06 | Neuravi Limited | Stentriever devices for removing an occlusive clot from a vessel and methods thereof |
US11529158B2 (en) | 2004-03-25 | 2022-12-20 | Inari Medical, Inc. | Method for treating vascular occlusion |
US11529495B2 (en) | 2019-09-11 | 2022-12-20 | Neuravi Limited | Expandable mouth catheter |
US11554005B2 (en) | 2018-08-13 | 2023-01-17 | Inari Medical, Inc. | System for treating embolism and associated devices and methods |
US11633198B2 (en) | 2020-03-05 | 2023-04-25 | Neuravi Limited | Catheter proximal joint |
US11712231B2 (en) | 2019-10-29 | 2023-08-01 | Neuravi Limited | Proximal locking assembly design for dual stent mechanical thrombectomy device |
US11717308B2 (en) | 2020-04-17 | 2023-08-08 | Neuravi Limited | Clot retrieval device for removing heterogeneous clots from a blood vessel |
US11730501B2 (en) | 2020-04-17 | 2023-08-22 | Neuravi Limited | Floating clot retrieval device for removing clots from a blood vessel |
US11737771B2 (en) | 2020-06-18 | 2023-08-29 | Neuravi Limited | Dual channel thrombectomy device |
US11759217B2 (en) | 2020-04-07 | 2023-09-19 | Neuravi Limited | Catheter tubular support |
US11779364B2 (en) | 2019-11-27 | 2023-10-10 | Neuravi Limited | Actuated expandable mouth thrombectomy catheter |
US11839725B2 (en) | 2019-11-27 | 2023-12-12 | Neuravi Limited | Clot retrieval device with outer sheath and inner catheter |
US11864781B2 (en) | 2020-09-23 | 2024-01-09 | Neuravi Limited | Rotating frame thrombectomy device |
US11864779B2 (en) | 2019-10-16 | 2024-01-09 | Inari Medical, Inc. | Systems, devices, and methods for treating vascular occlusions |
US11871946B2 (en) | 2020-04-17 | 2024-01-16 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11872354B2 (en) | 2021-02-24 | 2024-01-16 | Neuravi Limited | Flexible catheter shaft frame with seam |
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US11883043B2 (en) | 2020-03-31 | 2024-01-30 | DePuy Synthes Products, Inc. | Catheter funnel extension |
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Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008097993A2 (en) | 2007-02-05 | 2008-08-14 | Boston Scientific Limited | Thrombectomy apparatus and method |
US11589880B2 (en) | 2007-12-20 | 2023-02-28 | Angiodynamics, Inc. | System and methods for removing undesirable material within a circulatory system utilizing during a surgical procedure |
US10517617B2 (en) | 2007-12-20 | 2019-12-31 | Angiodynamics, Inc. | Systems and methods for removing undesirable material within a circulatory system utilizing a balloon catheter |
US9510854B2 (en) | 2008-10-13 | 2016-12-06 | Boston Scientific Scimed, Inc. | Thrombectomy catheter with control box having pressure/vacuum valve for synchronous aspiration and fluid irrigation |
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US20220104839A1 (en) | 2017-10-16 | 2022-04-07 | Retriever Medical, Inc. | Clot Removal Methods and Devices with Multiple Independently Controllable Elements |
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WO2020081814A1 (en) * | 2018-10-17 | 2020-04-23 | W. L. Gore & Associates, Inc. | Embolic filter with flexible coupling |
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US10653522B1 (en) | 2018-12-20 | 2020-05-19 | Vdyne, Inc. | Proximal tab for side-delivered transcatheter heart valve prosthesis |
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US11273032B2 (en) | 2019-01-26 | 2022-03-15 | Vdyne, Inc. | Collapsible inner flow control component for side-deliverable transcatheter heart valve prosthesis |
WO2020181154A2 (en) | 2019-03-05 | 2020-09-10 | Vdyne, Inc. | Tricuspid regurgitation control devices for orthogonal transcatheter heart valve prosthesis |
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US10631983B1 (en) | 2019-03-14 | 2020-04-28 | Vdyne, Inc. | Distal subannular anchoring tab for side-delivered transcatheter valve prosthesis |
US11076956B2 (en) | 2019-03-14 | 2021-08-03 | Vdyne, Inc. | Proximal, distal, and anterior anchoring tabs for side-delivered transcatheter mitral valve prosthesis |
US11173027B2 (en) | 2019-03-14 | 2021-11-16 | Vdyne, Inc. | Side-deliverable transcatheter prosthetic valves and methods for delivering and anchoring the same |
JP2022530764A (en) | 2019-05-04 | 2022-07-01 | ブイダイン,インコーポレイテッド | Tightening device and method for deploying a laterally delivered artificial heart valve with a native annulus. |
CA3152042A1 (en) | 2019-08-20 | 2021-02-25 | Vdyne, Inc. | Delivery and retrieval devices and methods for side-deliverable transcatheter prosthetic valves |
JP2022545728A (en) | 2019-08-26 | 2022-10-28 | ブイダイン,インコーポレイテッド | Transcatheter prosthetic valves capable of lateral delivery and methods for their delivery and fixation |
US11234813B2 (en) | 2020-01-17 | 2022-02-01 | Vdyne, Inc. | Ventricular stability elements for side-deliverable prosthetic heart valves and methods of delivery |
US11648020B2 (en) | 2020-02-07 | 2023-05-16 | Angiodynamics, Inc. | Device and method for manual aspiration and removal of an undesirable material |
US20220126073A1 (en) * | 2020-10-26 | 2022-04-28 | Medtronic Xomed, Inc. | System and Method for a Shunt |
US11679195B2 (en) | 2021-04-27 | 2023-06-20 | Contego Medical, Inc. | Thrombus aspiration system and methods for controlling blood loss |
AU2023214268A1 (en) * | 2022-08-12 | 2024-02-29 | Venturemed Group, Inc. | Intravascular catheter having an expandable incising portion and embolic protection device |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6511492B1 (en) * | 1998-05-01 | 2003-01-28 | Microvention, Inc. | Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders |
US20040073243A1 (en) * | 2000-06-29 | 2004-04-15 | Concentric Medical, Inc., A Delaware Corporation | Systems, methods and devices for removing obstructions from a blood vessel |
US20050119668A1 (en) * | 2003-09-18 | 2005-06-02 | Boston Scientific Scimed, Inc. | Medical retrieval devices and methods |
US20070118165A1 (en) * | 2004-03-08 | 2007-05-24 | Demello Jonathan R | System and method for removal of material from a blood vessel using a small diameter catheter |
US8852205B2 (en) * | 2011-03-09 | 2014-10-07 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
Family Cites Families (140)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3435826A (en) | 1964-05-27 | 1969-04-01 | Edwards Lab Inc | Embolectomy catheter |
US3923065A (en) | 1974-09-09 | 1975-12-02 | Jerome Nozick | Embolectomy catheter |
US4030503A (en) | 1975-11-05 | 1977-06-21 | Clark Iii William T | Embolectomy catheter |
US4883458A (en) | 1987-02-24 | 1989-11-28 | Surgical Systems & Instruments, Inc. | Atherectomy system and method of using the same |
US4650466A (en) | 1985-11-01 | 1987-03-17 | Angiobrade Partners | Angioplasty device |
US4873978A (en) | 1987-12-04 | 1989-10-17 | Robert Ginsburg | Device and method for emboli retrieval |
US4890611A (en) | 1988-04-05 | 1990-01-02 | Thomas J. Fogarty | Endarterectomy apparatus and method |
JPH0255064A (en) | 1988-08-03 | 1990-02-23 | Toa O | Skin removal for throm bus in blood vessel using catheter and throm bus removing system in blood vessel using catheter |
US5011488A (en) | 1988-12-07 | 1991-04-30 | Robert Ginsburg | Thrombus extraction system |
DE8910603U1 (en) | 1989-09-06 | 1989-12-07 | Guenther, Rolf W., Prof. Dr. | |
US5192290A (en) | 1990-08-29 | 1993-03-09 | Applied Medical Resources, Inc. | Embolectomy catheter |
US5129910A (en) | 1991-07-26 | 1992-07-14 | The Regents Of The University Of California | Stone expulsion stent |
US5192286A (en) | 1991-07-26 | 1993-03-09 | Regents Of The University Of California | Method and device for retrieving materials from body lumens |
WO1993019679A1 (en) | 1992-04-07 | 1993-10-14 | The Johns Hopkins University | A percutaneous mechanical fragmentation catheter system |
US5643297A (en) | 1992-11-09 | 1997-07-01 | Endovascular Instruments, Inc. | Intra-artery obstruction clearing apparatus and methods |
US5490859A (en) | 1992-11-13 | 1996-02-13 | Scimed Life Systems, Inc. | Expandable intravascular occlusion material removal devices and methods of use |
ES2123019T3 (en) | 1993-06-24 | 1999-01-01 | Schneider Europ Gmbh | ASPIRATION CATHETER. |
US5370653A (en) | 1993-07-22 | 1994-12-06 | Micro Therapeutics, Inc. | Thrombectomy method and apparatus |
US5476450A (en) | 1993-11-04 | 1995-12-19 | Ruggio; Joseph M. | Apparatus and method for aspirating intravascular, pulmonary and cardiac obstructions |
DE69529338T3 (en) | 1994-07-08 | 2007-05-31 | Ev3 Inc., Plymouth | Intravascular filter device |
US5827304A (en) | 1995-11-16 | 1998-10-27 | Applied Medical Resources Corporation | Intraluminal extraction catheter |
WO1997038631A1 (en) | 1996-04-18 | 1997-10-23 | Applied Medical Resources Corporation | Remote clot management |
US5972019A (en) | 1996-07-25 | 1999-10-26 | Target Therapeutics, Inc. | Mechanical clot treatment device |
US5882329A (en) | 1997-02-12 | 1999-03-16 | Prolifix Medical, Inc. | Apparatus and method for removing stenotic material from stents |
WO1998038929A1 (en) | 1997-03-06 | 1998-09-11 | Percusurge, Inc. | Intravascular aspiration system |
US5868708A (en) | 1997-05-07 | 1999-02-09 | Applied Medical Resources Corporation | Balloon catheter apparatus and method |
US5800525A (en) | 1997-06-04 | 1998-09-01 | Vascular Science, Inc. | Blood filter |
US6371935B1 (en) | 1999-01-22 | 2002-04-16 | Cardeon Corporation | Aortic catheter with flow divider and methods for preventing cerebral embolization |
US6066149A (en) | 1997-09-30 | 2000-05-23 | Target Therapeutics, Inc. | Mechanical clot treatment device with distal filter |
WO1999023952A1 (en) | 1997-11-12 | 1999-05-20 | William Dubrul | Biological passageway occlusion removal |
US20100030256A1 (en) | 1997-11-12 | 2010-02-04 | Genesis Technologies Llc | Medical Devices and Methods |
JP2002502626A (en) | 1998-02-10 | 2002-01-29 | アーテミス・メディカル・インコーポレイテッド | Supplementary device and method of using the same |
US6645222B1 (en) | 1998-05-13 | 2003-11-11 | Arteria Medical Science, Inc. | Puncture resistant branch artery occlusion device and methods of use |
US6306163B1 (en) | 1998-08-04 | 2001-10-23 | Advanced Cardiovascular Systems, Inc. | Assembly for collecting emboli and method of use |
US7128073B1 (en) | 1998-11-06 | 2006-10-31 | Ev3 Endovascular, Inc. | Method and device for left atrial appendage occlusion |
US6767353B1 (en) | 2002-03-01 | 2004-07-27 | Samuel Shiber | Thrombectomy catheter |
US20020169474A1 (en) | 1999-03-08 | 2002-11-14 | Microvena Corporation | Minimally invasive medical device deployment and retrieval system |
US6350271B1 (en) | 1999-05-17 | 2002-02-26 | Micrus Corporation | Clot retrieval device |
US6458139B1 (en) | 1999-06-21 | 2002-10-01 | Endovascular Technologies, Inc. | Filter/emboli extractor for use in variable sized blood vessels |
US7306618B2 (en) | 1999-07-30 | 2007-12-11 | Incept Llc | Vascular device for emboli and thrombi removal and methods of use |
US6544279B1 (en) | 2000-08-09 | 2003-04-08 | Incept, Llc | Vascular device for emboli, thrombus and foreign body removal and methods of use |
US6454775B1 (en) | 1999-12-06 | 2002-09-24 | Bacchus Vascular Inc. | Systems and methods for clot disruption and retrieval |
US6660013B2 (en) | 1999-10-05 | 2003-12-09 | Omnisonics Medical Technologies, Inc. | Apparatus for removing plaque from blood vessels using ultrasonic energy |
US6689150B1 (en) | 1999-10-27 | 2004-02-10 | Atritech, Inc. | Filter apparatus for ostium of left atrial appendage |
US6994092B2 (en) | 1999-11-08 | 2006-02-07 | Ev3 Sunnyvale, Inc. | Device for containing embolic material in the LAA having a plurality of tissue retention structures |
US6821297B2 (en) | 2000-02-02 | 2004-11-23 | Robert V. Snyders | Artificial heart valve, implantation instrument and method therefor |
US6514273B1 (en) | 2000-03-22 | 2003-02-04 | Endovascular Technologies, Inc. | Device for removal of thrombus through physiological adhesion |
US7285126B2 (en) | 2000-06-29 | 2007-10-23 | Concentric Medical, Inc. | Systems, methods and devices for removing obstructions from a blood vessel |
US6800083B2 (en) | 2001-04-09 | 2004-10-05 | Scimed Life Systems, Inc. | Compressible atherectomy burr |
US6635070B2 (en) | 2001-05-21 | 2003-10-21 | Bacchus Vascular, Inc. | Apparatus and methods for capturing particulate material within blood vessels |
US7097659B2 (en) | 2001-09-07 | 2006-08-29 | Medtronic, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
US6755847B2 (en) | 2001-10-05 | 2004-06-29 | Scimed Life Systems, Inc. | Emboli capturing device and method of manufacture therefor |
US7052500B2 (en) | 2001-10-19 | 2006-05-30 | Scimed Life Systems, Inc. | Embolus extractor |
US20030195553A1 (en) | 2002-04-12 | 2003-10-16 | Scimed Life Systems, Inc. | System and method for retaining vaso-occlusive devices within an aneurysm |
US8425549B2 (en) | 2002-07-23 | 2013-04-23 | Reverse Medical Corporation | Systems and methods for removing obstructive matter from body lumens and treating vascular defects |
JP2004097807A (en) | 2002-08-20 | 2004-04-02 | Nipro Corp | Thrombus capturing catheter |
US8114114B2 (en) | 2002-08-27 | 2012-02-14 | Emboline, Inc. | Embolic protection device |
US20050059993A1 (en) | 2003-09-17 | 2005-03-17 | Kamal Ramzipoor | Embolectomy device |
US7604650B2 (en) | 2003-10-06 | 2009-10-20 | 3F Therapeutics, Inc. | Method and assembly for distal embolic protection |
WO2005034776A1 (en) | 2003-10-07 | 2005-04-21 | Henry Ford Health System | Embolectomy catheter |
US7344550B2 (en) | 2003-10-21 | 2008-03-18 | Boston Scientific Scimed, Inc. | Clot removal device |
US7220269B1 (en) | 2003-11-06 | 2007-05-22 | Possis Medical, Inc. | Thrombectomy catheter system with occluder and method of using same |
JP2005230132A (en) | 2004-02-18 | 2005-09-02 | Asahi Intecc Co Ltd | Medical treatment tool |
US9526609B2 (en) | 2003-12-23 | 2016-12-27 | Boston Scientific Scimed, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
US20070179513A1 (en) | 2004-01-09 | 2007-08-02 | Deutsch Harvey L | Method and device for removing an occlusion |
US20080228209A1 (en) | 2004-03-08 | 2008-09-18 | Demello Richard M | System and method for removal of material from a blood vessel using a small diameter catheter |
US9039724B2 (en) | 2004-03-19 | 2015-05-26 | Aga Medical Corporation | Device for occluding vascular defects |
CA2549323C (en) | 2004-04-08 | 2009-07-21 | Aga Medical Corporation | Flanged occlusion devices and methods |
JP2005323702A (en) | 2004-05-13 | 2005-11-24 | Asahi Intecc Co Ltd | Medical treatment instrument |
US7794490B2 (en) | 2004-06-22 | 2010-09-14 | Boston Scientific Scimed, Inc. | Implantable medical devices with antimicrobial and biodegradable matrices |
DE102004040868A1 (en) | 2004-08-23 | 2006-03-09 | Miloslavski, Elina | Device for removing thrombi |
JP4324535B2 (en) | 2004-09-28 | 2009-09-02 | 朝日インテック株式会社 | Medical treatment tool |
US20060155323A1 (en) | 2005-01-07 | 2006-07-13 | Porter Stephen C | Intra-aneurysm devices |
US7244243B2 (en) | 2005-03-10 | 2007-07-17 | Banning Gray Lary | Catheter for treatment of severe pulmonary emboli |
US8475487B2 (en) | 2005-04-07 | 2013-07-02 | Medrad, Inc. | Cross stream thrombectomy catheter with flexible and expandable cage |
US7645290B2 (en) | 2005-05-05 | 2010-01-12 | Lucas Paul R | Multi-functional thrombectomy device |
EP3072475B1 (en) | 2005-05-27 | 2018-10-03 | HLT, Inc. | Stentless support structure |
US20060282111A1 (en) | 2005-06-09 | 2006-12-14 | Baylor College Of Medicine | Segmented Embolectomy Catheter |
WO2007013999A2 (en) | 2005-07-21 | 2007-02-01 | Florida International University | Collapsible heart valve with polymer leaflets |
US7938820B2 (en) | 2005-08-18 | 2011-05-10 | Lumen Biomedical, Inc. | Thrombectomy catheter |
DE102005052628B4 (en) | 2005-11-04 | 2014-06-05 | Jenavalve Technology Inc. | Self-expanding, flexible wire mesh with integrated valvular prosthesis for the transvascular heart valve replacement and a system with such a device and a delivery catheter |
WO2007054015A1 (en) | 2005-11-09 | 2007-05-18 | Ning Wen | An artificial heart valve stent and weaving method thereof |
US20070161963A1 (en) | 2006-01-09 | 2007-07-12 | Smalling Medical Ventures, Llc | Aspiration thrombectomy catheter system, and associated methods |
CA2641249C (en) | 2006-02-01 | 2014-08-05 | The Cleveland Clinic Foundation | A method and apparatus for increasing blood flow through an obstructed blood vessel |
EP1986568B1 (en) | 2006-02-03 | 2017-04-05 | Covidien LP | Methods and devices for restoring blood flow within blocked vasculature |
DE602007003871D1 (en) | 2006-03-06 | 2010-02-04 | Terumo Corp | atherectomy |
US8597341B2 (en) | 2006-03-06 | 2013-12-03 | David Elmaleh | Intravascular device with netting system |
DE602007007189D1 (en) | 2006-03-08 | 2010-07-29 | Wilson Cook Medical Inc | ARRANGEMENT FOR STONE CLEANING |
EP1849440A1 (en) | 2006-04-28 | 2007-10-31 | Younes Boudjemline | Vascular stents with varying diameter |
US7993302B2 (en) | 2006-05-09 | 2011-08-09 | Stephen Hebert | Clot retrieval device |
US20080234722A1 (en) * | 2006-06-14 | 2008-09-25 | Possis Medical, Inc. | Inferior vena cava filter on guidewire |
US8246641B2 (en) | 2006-11-08 | 2012-08-21 | Cook Medical Technolgies, LLC | Thrombus removal device |
EP2129425B1 (en) | 2006-11-29 | 2023-12-27 | Emboline, INC. | Embolic protection device |
US7914549B2 (en) | 2007-01-05 | 2011-03-29 | Hesham Morsi | Mechanical embolectomy and suction catheter |
EP2150181A1 (en) | 2007-05-31 | 2010-02-10 | Rex Medical, L.P. | Closure device for left atrial appendage |
US20110022149A1 (en) | 2007-06-04 | 2011-01-27 | Cox Brian J | Methods and devices for treatment of vascular defects |
EP2180839A4 (en) | 2007-08-06 | 2013-08-28 | Michael R Henson | Thrombectomy system and method |
US9414842B2 (en) | 2007-10-12 | 2016-08-16 | St. Jude Medical, Cardiology Division, Inc. | Multi-component vascular device |
US8066757B2 (en) | 2007-10-17 | 2011-11-29 | Mindframe, Inc. | Blood flow restoration and thrombus management methods |
US20110213290A1 (en) | 2007-12-20 | 2011-09-01 | Vortex Medical | Systems and Methods for Removing Undesirable Material Within a Circulatory System |
EP3311875A1 (en) | 2007-12-20 | 2018-04-25 | AngioDynamics, Inc. | Systems and methods for removing undesirable material within a circulatory system |
US8021380B2 (en) | 2008-01-11 | 2011-09-20 | Dustin Thompson | Obstruction removal system |
KR101819554B1 (en) | 2008-02-22 | 2018-01-17 | 마이크로 테라퓨틱스 인코포레이티드 | Methods and apparatus for flow restoration |
EP2633823B1 (en) | 2008-04-21 | 2016-06-01 | Covidien LP | Braid-ball embolic devices and delivery systems |
CN106974691A (en) | 2008-05-02 | 2017-07-25 | 斯昆特医疗公司 | Thread device for treating vascular defects |
US20090292307A1 (en) | 2008-05-22 | 2009-11-26 | Nasser Razack | Mechanical embolectomy device and method |
US20110190806A1 (en) | 2008-06-19 | 2011-08-04 | Angiodynamics, Inc. | Thrombectomy catheter and a device comprising the same |
WO2009155571A1 (en) | 2008-06-19 | 2009-12-23 | Coherex Medical, Inc. | Clot retrieval method and device |
CA2729750C (en) | 2008-07-03 | 2017-06-06 | Hotspur Technologies, Inc. | Apparatus and method comprising an expandable balloon or member for treating obstructions within body lumens |
US20110178539A1 (en) | 2008-07-11 | 2011-07-21 | Holmes Jr David R | Left atrial appendage occlusion devices |
WO2010010545A1 (en) | 2008-07-22 | 2010-01-28 | Neuravi Limited | Clot capture systems and associated methods |
DE102008038195A1 (en) | 2008-08-19 | 2010-02-25 | Phenox Gmbh | Device for opening occluded blood vessels |
ATE534336T1 (en) | 2008-08-29 | 2011-12-15 | Rapid Medical Ltd | EMBOLECTOMY DEVICE |
DE102008053635A1 (en) | 2008-10-29 | 2010-05-12 | Acandis Gmbh & Co. Kg | Medical device for recanalization of thrombi |
US20100114152A1 (en) | 2008-11-06 | 2010-05-06 | Himanshu Shukla | Minimally-Invasive Method and Device for Permanently Compressing Tissues within the Body |
EP2403583B1 (en) | 2009-03-06 | 2016-10-19 | Lazarus Effect, Inc. | Retrieval systems |
US20100249815A1 (en) | 2009-03-25 | 2010-09-30 | Cook Incorporated | Everted sheath thrombectomy device |
US20100256723A1 (en) | 2009-04-03 | 2010-10-07 | Medtronic Vascular, Inc. | Prosthetic Valve With Device for Restricting Expansion |
TR201907891T4 (en) | 2009-06-15 | 2019-06-21 | Perflow Medical Ltd | Apparatus for maintaining blood flow through a blocked vein. |
CH701695A1 (en) | 2009-08-27 | 2011-02-28 | Straub Medical Ag | Catheter with protection system for aspirating, fragmenting and out pumping of removable material from hollow bodies or vessels, in particular of the human or animal body. |
GB0915552D0 (en) | 2009-09-07 | 2009-10-07 | Icore Internat Ltd | Cable-routing |
GB2474866B8 (en) | 2009-10-29 | 2013-04-10 | Xiros Ltd | Knot slip resistant woven cord |
US20110152993A1 (en) | 2009-11-05 | 2011-06-23 | Sequent Medical Inc. | Multiple layer filamentary devices or treatment of vascular defects |
EP4257083A3 (en) | 2009-11-05 | 2024-01-17 | The Trustees of the University of Pennsylvania | Valve prosthesis |
DE102009052002B4 (en) | 2009-11-05 | 2012-09-27 | Acandis Gmbh & Co. Kg | A medical device for recanalizing body cavities and set comprising such device |
US20110146361A1 (en) | 2009-12-22 | 2011-06-23 | Edwards Lifesciences Corporation | Method of Peening Metal Heart Valve Stents |
EP2539012B1 (en) | 2010-02-23 | 2018-01-24 | Covidien LP | Devices for vascular recanalization |
WO2011130256A2 (en) | 2010-04-13 | 2011-10-20 | Lumen Biomedical, Inc. | Embolectomy devices and methods for treatment of acute ischemic stroke condition |
WO2012009675A2 (en) | 2010-07-15 | 2012-01-19 | Lazarus Effect, Inc. | Retrieval systems and methods for use thereof |
DE102010051740A1 (en) | 2010-11-19 | 2012-05-24 | Phenox Gmbh | thrombectomy |
WO2012075415A1 (en) | 2010-12-03 | 2012-06-07 | Vortex Medical, Inc. | Devices and methods for removing clots |
US20120271231A1 (en) | 2011-04-25 | 2012-10-25 | Sony Agrawal | Aspiration thrombectomy device |
CN104039245A (en) | 2011-08-19 | 2014-09-10 | 因赛普特斯医学有限责任公司 | Expandable occlusion device and methods |
IN2014DN05897A (en) | 2012-01-06 | 2015-06-05 | Inceptus Medical LLC | |
FR2985659B1 (en) | 2012-01-13 | 2015-03-06 | Assist Publ Hopitaux De Paris | DEVICE FOR ANCHORING A PROTHETIC CARDIAC VALVE. |
US9211132B2 (en) | 2012-06-27 | 2015-12-15 | MicoVention, Inc. | Obstruction removal system |
US20150238207A1 (en) | 2012-09-24 | 2015-08-27 | Inceptus Medical LLC | Device and method for treating vascular occlusion |
US8784434B2 (en) | 2012-11-20 | 2014-07-22 | Inceptus Medical, Inc. | Methods and apparatus for treating embolism |
WO2015006782A1 (en) | 2013-07-12 | 2015-01-15 | Inceptus Medical, Llc | Methods and apparatus for treating pulmonary embolism |
WO2015061365A1 (en) | 2013-10-21 | 2015-04-30 | Inceptus Medical, Llc | Methods and apparatus for treating embolism |
-
2014
- 2014-06-09 US US14/299,933 patent/US9259237B2/en active Active
- 2014-06-09 US US14/299,997 patent/US20150018860A1/en not_active Abandoned
- 2014-07-14 US US14/904,647 patent/US20160143721A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6511492B1 (en) * | 1998-05-01 | 2003-01-28 | Microvention, Inc. | Embolectomy catheters and methods for treating stroke and other small vessel thromboembolic disorders |
US20040073243A1 (en) * | 2000-06-29 | 2004-04-15 | Concentric Medical, Inc., A Delaware Corporation | Systems, methods and devices for removing obstructions from a blood vessel |
US20050119668A1 (en) * | 2003-09-18 | 2005-06-02 | Boston Scientific Scimed, Inc. | Medical retrieval devices and methods |
US20070118165A1 (en) * | 2004-03-08 | 2007-05-24 | Demello Jonathan R | System and method for removal of material from a blood vessel using a small diameter catheter |
US8852205B2 (en) * | 2011-03-09 | 2014-10-07 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
Cited By (154)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11839393B2 (en) | 2004-03-25 | 2023-12-12 | Inari Medical, Inc. | Method for treating vascular occlusion |
US11832837B2 (en) | 2004-03-25 | 2023-12-05 | Inari Medical, Inc. | Method for treating vascular occlusion |
US11925369B2 (en) | 2004-03-25 | 2024-03-12 | Inari Medical, Inc. | Method for treating vascular occlusion |
US11832838B2 (en) | 2004-03-25 | 2023-12-05 | Inari Medical, Inc. | Method for treating vascular occlusion |
US11529158B2 (en) | 2004-03-25 | 2022-12-20 | Inari Medical, Inc. | Method for treating vascular occlusion |
US10582939B2 (en) | 2008-07-22 | 2020-03-10 | Neuravi Limited | Clot capture systems and associated methods |
US11529157B2 (en) | 2008-07-22 | 2022-12-20 | Neuravi Limited | Clot capture systems and associated methods |
US9402707B2 (en) | 2008-07-22 | 2016-08-02 | Neuravi Limited | Clot capture systems and associated methods |
US11871949B2 (en) | 2010-10-22 | 2024-01-16 | Neuravi Limited | Clot engagement and removal system |
US9351749B2 (en) | 2010-10-22 | 2016-05-31 | Neuravi Limited | Clot engagement and removal system |
US10292723B2 (en) | 2010-10-22 | 2019-05-21 | Neuravi Limited | Clot engagement and removal system |
US9463036B2 (en) | 2010-10-22 | 2016-10-11 | Neuravi Limited | Clot engagement and removal system |
US11246612B2 (en) | 2010-10-22 | 2022-02-15 | Neuravi Limited | Clot engagement and removal system |
US10743894B2 (en) | 2011-03-09 | 2020-08-18 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10292722B2 (en) | 2011-03-09 | 2019-05-21 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US9642639B2 (en) | 2011-03-09 | 2017-05-09 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10034680B2 (en) | 2011-03-09 | 2018-07-31 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US10952760B2 (en) | 2011-03-09 | 2021-03-23 | Neuravi Limited | Clot retrieval device for removing a clot from a blood vessel |
US11259824B2 (en) | 2011-03-09 | 2022-03-01 | Neuravi Limited | Clot retrieval device for removing occlusive clot from a blood vessel |
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US10299811B2 (en) | 2011-03-09 | 2019-05-28 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
US11147571B2 (en) | 2012-09-24 | 2021-10-19 | Inari Medical, Inc. | Device and method for treating vascular occlusion |
US10045790B2 (en) | 2012-09-24 | 2018-08-14 | Inari Medical, Inc. | Device and method for treating vascular occlusion |
US10588655B2 (en) | 2012-11-20 | 2020-03-17 | Inari Medical, Inc. | Methods and apparatus for treating embolism |
US10709471B2 (en) | 2012-11-20 | 2020-07-14 | Inari Medical, Inc. | Methods and apparatus for treating embolism |
US9717519B2 (en) | 2012-11-20 | 2017-08-01 | Inceptus Medical, Llc | Methods and apparatus for treating embolism |
US11648028B2 (en) | 2012-11-20 | 2023-05-16 | Inari Medical, Inc. | Methods and apparatus for treating embolism |
US10335186B2 (en) | 2012-11-20 | 2019-07-02 | Inari Medical, Inc. | Methods and apparatus for treating embolism |
US10004531B2 (en) | 2012-11-20 | 2018-06-26 | Inari Medical, Inc. | Methods and apparatus for treating embolism |
US10517622B2 (en) | 2013-03-13 | 2019-12-31 | Neuravi Limited | Clot removal device |
US9642635B2 (en) | 2013-03-13 | 2017-05-09 | Neuravi Limited | Clot removal device |
US10201360B2 (en) | 2013-03-14 | 2019-02-12 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
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US11058445B2 (en) | 2013-10-21 | 2021-07-13 | Inari Medical, Inc. | Methods and apparatus for treating embolism |
US11937838B2 (en) | 2013-10-21 | 2024-03-26 | Inari Medical, Inc. | Methods and apparatus for treating embolism |
US10238406B2 (en) | 2013-10-21 | 2019-03-26 | Inari Medical, Inc. | Methods and apparatus for treating embolism |
US10285720B2 (en) | 2014-03-11 | 2019-05-14 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US11484328B2 (en) | 2014-03-11 | 2022-11-01 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
US9526864B2 (en) | 2014-06-09 | 2016-12-27 | Inceptus Medical, Llc | Retraction and aspiration device for treating embolism and associated systems and methods |
US9526865B2 (en) | 2014-06-09 | 2016-12-27 | Inceptus Medical, Llc | Retraction and aspiration device for treating embolism and associated systems and methods |
US10349960B2 (en) | 2014-06-09 | 2019-07-16 | Inari Medical, Inc. | Retraction and aspiration device for treating embolism and associated systems and methods |
US10441301B2 (en) | 2014-06-13 | 2019-10-15 | Neuravi Limited | Devices and methods for removal of acute blockages from blood vessels |
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US11944333B2 (en) | 2014-06-30 | 2024-04-02 | Neuravi Limited | System for removing a clot from a blood vessel |
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US9463035B1 (en) * | 2015-09-28 | 2016-10-11 | GW Medical LLC | Mechanical thrombectomy apparatuses and methods |
US10271864B2 (en) | 2015-09-28 | 2019-04-30 | Stryker Corporation | Mechanical thrombectomy apparatuses and methods |
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US11058451B2 (en) | 2015-10-23 | 2021-07-13 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
US10342571B2 (en) | 2015-10-23 | 2019-07-09 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
US11918244B2 (en) | 2015-10-23 | 2024-03-05 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
US11918243B2 (en) | 2015-10-23 | 2024-03-05 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
US10524811B2 (en) | 2015-10-23 | 2020-01-07 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
WO2017072761A1 (en) * | 2015-10-26 | 2017-05-04 | Amnis Therapeutics Ltd. | Systems for thrombectomy |
US11179170B2 (en) | 2015-10-26 | 2021-11-23 | Amnis Therapeutics Ltd | Systems for thrombectomy |
US11433218B2 (en) | 2015-12-18 | 2022-09-06 | Inari Medical, Inc. | Catheter shaft and associated devices, systems, and methods |
US10512478B2 (en) | 2016-04-25 | 2019-12-24 | Stryker Corporation | Clot-engulfing mechanical thrombectomy apparatuses |
US10842513B2 (en) | 2016-04-25 | 2020-11-24 | Stryker Corporation | Methods for advancing inverting mechanical thrombectomy apparatuses in the vasculature |
US10561431B2 (en) * | 2016-04-25 | 2020-02-18 | Stryker Corporation | Pre-loaded inverting tractor thrombectomy apparatuses and methods |
US9962178B2 (en) * | 2016-04-25 | 2018-05-08 | Stryker Corporation | Pre-loaded inverting tractor thrombectomy apparatuses |
US10028759B2 (en) | 2016-04-25 | 2018-07-24 | Stryker Corporation | Anti-jamming and macerating thrombectomy apparatuses and methods |
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US20170303942A1 (en) * | 2016-04-25 | 2017-10-26 | Stryker Corporation | Pre-loaded inverting tractor thrombectomy apparatuses and methods |
US11497512B2 (en) | 2016-04-25 | 2022-11-15 | Stryker Corporation | Inverting thrombectomy apparatuses and methods |
US11896247B2 (en) | 2016-04-25 | 2024-02-13 | Stryker Corporation | Inverting mechanical thrombectomy apparatuses |
US11497514B2 (en) | 2016-04-25 | 2022-11-15 | Stryker Corporation | Pre-loaded inverting tractor thrombectomy apparatuses and methods |
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US11395667B2 (en) | 2016-08-17 | 2022-07-26 | Neuravi Limited | Clot retrieval system for removing occlusive clot from a blood vessel |
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US10610245B2 (en) | 2016-09-12 | 2020-04-07 | Stryker Corporation | Self-rolling thrombectomy apparatuses and methods |
US11627973B2 (en) | 2016-09-12 | 2023-04-18 | Stryker Corporation | Self-rolling apparatuses and methods for removing material from a body lumen |
US11898282B2 (en) | 2016-10-14 | 2024-02-13 | Inceptus Medical, Llc | Braiding machine and methods of use |
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US11806033B2 (en) | 2017-01-10 | 2023-11-07 | Inari Medical, Inc. | Devices and methods for treating vascular occlusion |
US10912577B2 (en) | 2017-01-10 | 2021-02-09 | Inari Medical, Inc. | Devices and methods for treating vascular occlusion |
US10376267B2 (en) | 2017-02-24 | 2019-08-13 | Inceptus Medical, Llc | Vascular occlusion devices and methods |
US10660648B2 (en) | 2017-02-24 | 2020-05-26 | Inceptus Medical, Llc | Vascular occlusion devices and methods |
US11304701B2 (en) | 2017-02-24 | 2022-04-19 | Inceptus Medical, Llc | Vascular occlusion devices and methods |
US11844921B2 (en) | 2017-09-06 | 2023-12-19 | Inari Medical, Inc. | Hemostasis valves and methods of use |
US11865291B2 (en) | 2017-09-06 | 2024-01-09 | Inari Medical, Inc. | Hemostasis valves and methods of use |
US11000682B2 (en) | 2017-09-06 | 2021-05-11 | Inari Medical, Inc. | Hemostasis valves and methods of use |
US11697012B2 (en) | 2017-09-06 | 2023-07-11 | Inari Medical, Inc. | Hemostasis valves and methods of use |
US11697011B2 (en) | 2017-09-06 | 2023-07-11 | Inari Medical, Inc. | Hemostasis valves and methods of use |
US11885051B2 (en) | 2017-10-14 | 2024-01-30 | Inceptus Medical, Llc | Braiding machine and methods of use |
US10912576B2 (en) | 2017-11-09 | 2021-02-09 | Stryker Corporation | Inverting thrombectomy apparatuses having enhanced tracking |
US11812980B2 (en) | 2017-11-09 | 2023-11-14 | Stryker Corporation | Inverting thrombectomy apparatuses having enhanced tracking |
US10779843B2 (en) | 2017-11-09 | 2020-09-22 | Stryker Corporation | Inverting thrombectomy apparatuses having enhanced tracking |
US10835268B2 (en) | 2017-11-09 | 2020-11-17 | Stryker Corporation | Inverting thrombectomy apparatuses having enhanced tracking |
US10856894B2 (en) | 2017-11-09 | 2020-12-08 | Stryker Corporation | Inverting thrombectomy apparatuses having enhanced tracking |
US10863999B2 (en) | 2017-11-09 | 2020-12-15 | Stryker Corporation | Inverting thrombectomy apparatuses having enhanced tracking |
US11849963B2 (en) | 2018-01-26 | 2023-12-26 | Inari Medical, Inc. | Single insertion delivery system for treating embolism and associated systems and methods |
US11154314B2 (en) | 2018-01-26 | 2021-10-26 | Inari Medical, Inc. | Single insertion delivery system for treating embolism and associated systems and methods |
US11896251B2 (en) | 2018-05-14 | 2024-02-13 | Stryker Corporation | Inverting thrombectomy apparatuses and methods of use |
US11103265B2 (en) | 2018-05-14 | 2021-08-31 | Stryker Corporation | Inverting thrombectomy apparatuses and methods of use |
US11554005B2 (en) | 2018-08-13 | 2023-01-17 | Inari Medical, Inc. | System for treating embolism and associated devices and methods |
US11559382B2 (en) | 2018-08-13 | 2023-01-24 | Inari Medical, Inc. | System for treating embolism and associated devices and methods |
US11890180B2 (en) | 2018-08-13 | 2024-02-06 | Inari Medical, Inc. | System for treating embolism and associated devices and methods |
US11833023B2 (en) | 2018-08-13 | 2023-12-05 | Inari Medical, Inc. | System for treating embolism and associated devices and methods |
US11642209B2 (en) | 2018-08-13 | 2023-05-09 | Inari Medical, Inc. | System for treating embolism and associated devices and methods |
US11744691B2 (en) | 2018-08-13 | 2023-09-05 | Inari Medical, Inc. | System for treating embolism and associated devices and methods |
US11771450B2 (en) | 2018-09-10 | 2023-10-03 | Stryker Corporation | Inverting thrombectomy apparatuses and methods of use |
US11253291B2 (en) | 2018-09-10 | 2022-02-22 | Stryker Corporation | Laser slotted grabbing device |
US10835269B1 (en) | 2018-09-10 | 2020-11-17 | Stryker Corporation | Inverting thrombectomy apparatuses and methods of use |
US10842498B2 (en) | 2018-09-13 | 2020-11-24 | Neuravi Limited | Systems and methods of restoring perfusion to a vessel |
US11406416B2 (en) | 2018-10-02 | 2022-08-09 | Neuravi Limited | Joint assembly for vasculature obstruction capture device |
US11311304B2 (en) | 2019-03-04 | 2022-04-26 | Neuravi Limited | Actuated clot retrieval catheter |
US11529495B2 (en) | 2019-09-11 | 2022-12-20 | Neuravi Limited | Expandable mouth catheter |
US11937834B2 (en) | 2019-10-16 | 2024-03-26 | Inari Medical, Inc. | Systems, devices, and methods for treating vascular occlusions |
US11864779B2 (en) | 2019-10-16 | 2024-01-09 | Inari Medical, Inc. | Systems, devices, and methods for treating vascular occlusions |
US11712231B2 (en) | 2019-10-29 | 2023-08-01 | Neuravi Limited | Proximal locking assembly design for dual stent mechanical thrombectomy device |
US11839725B2 (en) | 2019-11-27 | 2023-12-12 | Neuravi Limited | Clot retrieval device with outer sheath and inner catheter |
US11779364B2 (en) | 2019-11-27 | 2023-10-10 | Neuravi Limited | Actuated expandable mouth thrombectomy catheter |
US11517340B2 (en) | 2019-12-03 | 2022-12-06 | Neuravi Limited | Stentriever devices for removing an occlusive clot from a vessel and methods thereof |
US11944327B2 (en) | 2020-03-05 | 2024-04-02 | Neuravi Limited | Expandable mouth aspirating clot retrieval catheter |
US11633198B2 (en) | 2020-03-05 | 2023-04-25 | Neuravi Limited | Catheter proximal joint |
US11883043B2 (en) | 2020-03-31 | 2024-01-30 | DePuy Synthes Products, Inc. | Catheter funnel extension |
US11759217B2 (en) | 2020-04-07 | 2023-09-19 | Neuravi Limited | Catheter tubular support |
US11871946B2 (en) | 2020-04-17 | 2024-01-16 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
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US11737771B2 (en) | 2020-06-18 | 2023-08-29 | Neuravi Limited | Dual channel thrombectomy device |
US11937836B2 (en) | 2020-06-22 | 2024-03-26 | Neuravi Limited | Clot retrieval system with expandable clot engaging framework |
US11439418B2 (en) | 2020-06-23 | 2022-09-13 | Neuravi Limited | Clot retrieval device for removing clot from a blood vessel |
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US11864781B2 (en) | 2020-09-23 | 2024-01-09 | Neuravi Limited | Rotating frame thrombectomy device |
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US11872354B2 (en) | 2021-02-24 | 2024-01-16 | Neuravi Limited | Flexible catheter shaft frame with seam |
US11937839B2 (en) | 2021-09-28 | 2024-03-26 | Neuravi Limited | Catheter with electrically actuated expandable mouth |
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US20150018859A1 (en) | 2015-01-15 |
US9259237B2 (en) | 2016-02-16 |
US20160143721A1 (en) | 2016-05-26 |
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