US20130261656A1 - Embolic coil detachment mechanism with polymer tether - Google Patents
Embolic coil detachment mechanism with polymer tether Download PDFInfo
- Publication number
- US20130261656A1 US20130261656A1 US13/436,236 US201213436236A US2013261656A1 US 20130261656 A1 US20130261656 A1 US 20130261656A1 US 201213436236 A US201213436236 A US 201213436236A US 2013261656 A1 US2013261656 A1 US 2013261656A1
- Authority
- US
- United States
- Prior art keywords
- therapeutic
- bead
- actuator
- anchor
- distal end
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/128—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord for applying or removing clamps or clips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12154—Coils or wires having stretch limiting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
- A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
- A61B2017/12068—Details concerning the detachment of the occluding device from the introduction device detachable by heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
- A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
- A61B2017/12068—Details concerning the detachment of the occluding device from the introduction device detachable by heat
- A61B2017/12072—Details concerning the detachment of the occluding device from the introduction device detachable by heat the heat created by laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
- A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
- A61B2017/12068—Details concerning the detachment of the occluding device from the introduction device detachable by heat
- A61B2017/12077—Joint changing shape upon application of heat, e.g. bi-metal or reversible thermal memory
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Otolaryngology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Surgical Instruments (AREA)
Abstract
Description
- The present invention relates to a medical device for placing an embolic coil at a preselected location within a vessel of the human body, and more particularly, relates to a flexible delivery member having a heating element and a polymer tether member at the distal tip of the delivery member for holding the embolic coil in order to transport the coil to a desired position within the vessel and release the embolic coil at that position.
- For many years flexible catheters have been used to place various objects within the vessels of the human body. Such devices include dilatation balloons, radiopaque markers, liquid medications and various types of occlusion devices such as balloons and embolic coils. Occlusion devices including embolic coils can be used to treat aneurysms or to occlude the blood vessel at a target location.
- Coils which are placed in vessels may take the form of helically wound coils, or alternatively, may be randomly wound coils, convoluted coils, coils wound within other coils or many other such configurations to better occlude a blood vessel. Embolic coils are generally formed of radiopaque biocompatible metallic materials, such as platinum, gold, tungsten, or alloys of these metals. The coils can be coated with various materials to improve thrombogenicity. Often times, several coils are placed at a given location in order to occlude the flow of blood through the vessel by promoting thrombus formation at the particular location. The decreased blood flow reduces the pressure on the aneurysm and reduces the risk of a ruptured.
- In the past, embolic coils have been placed within the distal end of the catheter. When the distal end of the catheter is properly positioned the coil may then be pushed out of the end of the catheter with, for example, a guidewire to release the coil at the desired location. This procedure of placement of the embolic coil is conducted under fluoroscopic visualization such that the movement of the coil through the vasculature of the body may be monitored and the coil may be placed at the desired location. With these placements systems there is very little control over the exact placement of the coil since the coil may be ejected to a position some distance beyond the end of the catheter.
- Patients with potentially life-threatening hemorrhagic brain aneurysms are in need of a safe, reliable, accurate, and fast release mechanism for the deposition of embolic coils via catheters. Numerous procedures have been developed to enable more accurate positioning of coils within a vessel. One commercial product of current use is the Guglielmi Detachable Coil (GDC). The GDC utilizes the electrolytical dissolution of a designated guidewire junction to generate the release action. This procedure typically takes 10-30 minutes and is difficult to control in a reliable fashion. The effects of the dissolved material in the blood stream create a potential hazard to the patient. Problems that have been associated with the release of the coil include the force of the coil exiting the delivery catheter causing the coil to overshoot the desired site or dislodge previously deployed coils. Thus, even with the numerous prior efforts to develop miniature actuators for catheter-based therapeutic application, there remains a need for safe, fast release actuator mechanisms for the delivery of embolic coils, for example.
- Another problem with embolic coil delivery systems that rely on a stiff pusher wire extending through the entire length of the catheter to push an element out of the distal end of the catheter is that the pusher wire inherently causes the catheter to be very stiff with the result that it is very difficult to guide the catheter through the vasculature of the body. Accordingly, there is a need for a mechanism for deploying embolic coils from the distal end of a catheter having a flexible body.
- There is also a need for precise therapeutic actuators configured to deploy therapeutic elements or devices, e.g. embolic coils, within the narrow confines of blood vessels in the human brain, e.g. 250-500 micrometers in diameter. The present invention satisfies these and other needs.
- Briefly and in general terms, the present invention provides for a release mechanism, a therapeutic actuator, or a system for delivering a therapeutic element or device to a target location. The target location is a site within the vasculature of the human body, for example, a blood vessel in the brain in order to treat an aneurysm.
- In its most basic form, the release mechanism includes a therapeutic element, such as an embolic coil, secured to a heating/delivery system through a polymer tether. Upon sufficient heat transfer to from the heating/delivery system to the polymer tether the connection between the heating/delivery system and the therapeutic element is severed. This severance may occur through a melting of the polymer tether which causes the connected coil to break free and disengage from the heating/delivery system. Or, severance of the connection between the therapeutic element and the heating/delivery system through the polymer tether may occur by the tether undergoing a phase transformation that causes it to deform in a manner that releases it from engagement with the connector element securing it to the heating/delivery system. For example, if one end of the polymer tether is enlarged to retain itself in position through a hole in the connector element, heating the polymer tether may cause the enlarged region to narrow and slide through the hole in the connector element, thereby releasing the therapeutic element from the heating/delivery system.
-
FIG. 1 is a cross sectional view of a system for delivery of a therapeutic device in accordance with an embodiment of the present invention with the therapeutic device in a first retained configuration. -
FIG. 2 is a cross sectional view of a system for delivery of a therapeutic device in accordance with an embodiment of the present invention with the therapeutic device in a second deployed configuration. - Referring to the drawings, which are provided by way of example, and not by way of limitation, the present invention provides for a therapeutic element delivery system 100 (which may also be referred to as a therapeutic actuator or a release mechanism) including a
flexible tube 102 for delivering atherapeutic element 140 to a target site within a body and apolymeric element 122 including atether portion 130 that may be thermally severed, thepolymeric element 122 securing thetherapeutic element 140 to theflexible tube 102. Thetherapeutic element 140 may be an embolic coil or another occlusive device that serves to occlude an aneurysm by filling the aneurysm pouch, creating a physical barrier to reduce blood flow into the aneurysm, and inducing thrombosis or clotting therein. Thetube 102 may be flexible along its entire length or the flexible region may be restricted to the distal end of the tube. - The
therapeutic element 140 is secured to theflexible tube 102 through apolymeric element 122 that includes atether portion 130. According to one of several embodiments, thepolymeric element 122 is part of a secure and release system that may also include abulb 114, atether portion 130, anaggregate portion 135, ananchor 142, a stretchresistant member 124, and adistal bead 126. The interconnection of these elements is discussed below. - The capability of the
tether portion 130 to be thermally decoupled to deploy the therapeutic element is beneficial in that is allows prompt precise placement of the therapeutic element at the target site. Whereas prior art devices have relied upon pusher wires and other ejection mechanisms that exert an often uncontrollable and unpredictable force on the therapeutic element to deploy it, the thermally activated tether portion can be quickly and easily decoupled without propelling the therapeutic element out of the delivery tube. This is desirable as uncontrolled therapeutic elements that shoot out of the tube may result in inaccurately placed coils or coils that dislodge other previously placed coils. - Within the flexible tube at least one electrical conductor is provided. For example, there may be a positively charged
electrical conductor 104 and a negatively chargedelectrical conductor 106. The electrical conductors are attached to a thermallyresponsive element 112 or heating element throughattachment points bulb 122 may also be provided to secure atether portion 130 of apolymeric element 122 to the thermallyresponsive element 112 and to at least one electrical conductor, thereby enabling the thermallyresponsive element 112 to transfer heat to thepolymeric element 122 through the proximal tether 118. - The
polymeric element 122 also includes anaggregate portion 120 connected to ananchor 142. For example, theanchor 142 may be U-shaped and disposed into theaggregate portion 120 of thepolymeric element 122. Theanchor 142 may be formed of metal or another material resistant to deformation at the temperature that causes deformation of thepolymeric element 122. Theanchor 142 and at least theaggregate portion 120 of thepolymeric element 122 are disposed within an internal lumen of thetherapeutic element 140. Theanchor 142 may be secured to theaggregate portion 120 in the molding process of thepolymeric element 122 in the molding process, or it may be affixed by adhesives, solder, or welding. - The
anchor 142 is connected to a stretchresistant member 124 at its distal end. For example, the stretchresistant member 124 may loop through a U-shapedanchor 142. The stretchresistant member 124 is attached to abead 126 at its distal end. Thebead 126 holds thetherapeutic element 140 as shown inFIG. 1 in which thetherapeutic element 140 is retained in thedelivery tube 102. A distal outer surface of the bead may be substantially hemispherical, curved, or rounded so as to facilitate an atraumatic introduction of thetherapeutic element 140. The stretchresistant member 124 may, but need not, be integrally formed with thedistal bead 126. When thetether portion 130 is heated by theheating element 112, the tether weakens and narrows as it melts until it breaks. When thetether portion 130 breaks, the tension in the polymeric element that holds thetherapeutic element 140 is released as seen inFIG. 2 andtherapeutic element 140 along with its associatedbead 126 is released into the patient's body. - The heating of the
tether portion 130 by theheating element 112 may sever the connection between thetherapeutic element 140 andflexible tube 102 in various ways. For example, according to one embodiment, the tether may be formed of a polymeric material that melts and splits into two or more sections thereby disengaging from the connector that secures it to the heating/delivery system. As another example, according to another embodiment, the tether has a bulb on theproximal end 114 that, when heated, my shrink to the point where it can slide through theheating element 112, releasing thetherapeutic element 140. The change in shape of thebulb 114 induces thetether 130 to release itself fromflexible tubing 102 and position thetherapeutic element 140 at the desired location. - The material used to form the tether portion 130 (and/or bulb 114) of the
polymeric element 122 is designed to melt, split, or undergo a phase transformation at a temperature sufficiently above normal body temperature and febrile temperatures so that it is not prematurely activated. The heat necessary to achieve this higher decoupling temperature can be supplied by an auxiliary electrical heating system or an alternative energy source. For example, there may beelectrical conductors resistive heating coil 112 disposed within the body of the flexible delivery tube. Alternatively, there may be a laser or optical fiber (not shown) in the tube in thermal communication with thepolymeric tether 130. - Preferably, the
polymeric element 122 anddistal bead 126 are formed of non-toxic, biocompatible materials that may also be biodegradable, bioabsorbable or bioerodible such that when they are released as a result of the decoupling with theflexible tubing 102 they do not pose a hazard from being ejected into the bloodstream. - According to one of several embodiments, the therapeutic element delivery system as described herein is capable of operating in small (250-500 micrometers) diameter applications, such as in veins in the human brain, which enables catheter-based devices to reach and treat an aneurysm in the brain.
- It will be apparent from the foregoing that while particular forms of the invention have been illustrated and described, various modifications can be made without departing from the spirit and scope of the invention. Accordingly, it is not intended that the invention be limited, except as by the appended claims.
Claims (15)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/436,236 US8932318B2 (en) | 2012-03-30 | 2012-03-30 | Embolic coil detachment mechanism with polymer tether |
CA2810090A CA2810090A1 (en) | 2012-03-30 | 2013-03-22 | Embolic coil detachment mechanism with polymer tether |
AU2013202095A AU2013202095B2 (en) | 2012-03-30 | 2013-03-27 | Embolic coil detachment mechanism with polymer tether |
CN201310103816.2A CN103356259B (en) | 2012-03-30 | 2013-03-28 | There is the Embolic coil detachment mechanism of polymer tether |
JP2013068491A JP6173738B2 (en) | 2012-03-30 | 2013-03-28 | Embolization coil separation mechanism using polymer tether |
KR1020130034164A KR20130111421A (en) | 2012-03-30 | 2013-03-29 | Embolic coil detachment mechanism with polymer tether |
BRBR102013007796-8A BR102013007796A2 (en) | 2012-03-30 | 2013-04-01 | Embolization spring disconnect mechanism with a polymer cable |
ES14162781.0T ES2621258T3 (en) | 2012-03-30 | 2013-04-02 | Release mechanism of embolic coils with polymer anchor |
ES13162032.0T ES2586861T3 (en) | 2012-03-30 | 2013-04-02 | Release mechanism of embolic coils with polymer anchor |
EP13162032.0A EP2644130B1 (en) | 2012-03-30 | 2013-04-02 | Embolic coil detachment mechanism with polymer tether |
EP14162781.0A EP2752163B1 (en) | 2012-03-30 | 2013-04-02 | Embolic coil detachment mechanism with polymer tether |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/436,236 US8932318B2 (en) | 2012-03-30 | 2012-03-30 | Embolic coil detachment mechanism with polymer tether |
Publications (2)
Publication Number | Publication Date |
---|---|
US20130261656A1 true US20130261656A1 (en) | 2013-10-03 |
US8932318B2 US8932318B2 (en) | 2015-01-13 |
Family
ID=48049818
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/436,236 Expired - Fee Related US8932318B2 (en) | 2012-03-30 | 2012-03-30 | Embolic coil detachment mechanism with polymer tether |
Country Status (9)
Country | Link |
---|---|
US (1) | US8932318B2 (en) |
EP (2) | EP2644130B1 (en) |
JP (1) | JP6173738B2 (en) |
KR (1) | KR20130111421A (en) |
CN (1) | CN103356259B (en) |
AU (1) | AU2013202095B2 (en) |
BR (1) | BR102013007796A2 (en) |
CA (1) | CA2810090A1 (en) |
ES (2) | ES2621258T3 (en) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20140277094A1 (en) * | 2013-03-14 | 2014-09-18 | Stryker Nv Operations Limited | Vaso-occlusive device delivery system |
US20140277092A1 (en) * | 2013-03-14 | 2014-09-18 | Stryker Nv Operations Limited | Vaso-occlusive device delivery system |
US20150032147A1 (en) * | 2013-07-29 | 2015-01-29 | Insera Therapeutics, Inc. | Reversibly coupled joints |
US9034007B2 (en) | 2007-09-21 | 2015-05-19 | Insera Therapeutics, Inc. | Distal embolic protection devices with a variable thickness microguidewire and methods for their use |
US9314324B2 (en) | 2013-03-15 | 2016-04-19 | Insera Therapeutics, Inc. | Vascular treatment devices and methods |
WO2016196519A1 (en) | 2015-05-29 | 2016-12-08 | Microvention, Inc. | Catheter circuit |
US9592068B2 (en) | 2013-03-15 | 2017-03-14 | Insera Therapeutics, Inc. | Free end vascular treatment systems |
US9750524B2 (en) | 2013-03-15 | 2017-09-05 | Insera Therapeutics, Inc. | Shape-set textile structure based mechanical thrombectomy systems |
US9808599B2 (en) | 2013-12-20 | 2017-11-07 | Microvention, Inc. | Device delivery system |
US9867622B2 (en) | 2014-04-11 | 2018-01-16 | Microvention, Inc. | Implant delivery system |
US20180303486A1 (en) * | 2013-05-06 | 2018-10-25 | Sequent Medical, Inc. | Embolic Occlusion Device And Method |
US10390926B2 (en) | 2013-07-29 | 2019-08-27 | Insera Therapeutics, Inc. | Aspiration devices and methods |
US11051823B2 (en) * | 2016-06-01 | 2021-07-06 | DePuy Synthes Products, Inc. | Endovascular detachment system with flexible distal end and heater activated detachment |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9855050B2 (en) | 2014-09-19 | 2018-01-02 | DePuy Synthes Products, Inc. | Vasculature occlusion device detachment system with tapered corewire and single loop fuse detachment |
US9782178B2 (en) * | 2014-09-19 | 2017-10-10 | DePuy Synthes Products, Inc. | Vasculature occlusion device detachment system with tapered corewire and heater activated fiber detachment |
US10631869B2 (en) * | 2015-10-06 | 2020-04-28 | Boston Scientific Scimed, Inc. | Pusher arm and ball release mechanism for embolic coils |
WO2018125936A1 (en) * | 2016-12-27 | 2018-07-05 | DePuy Synthes Products, Inc. | Systems, methods, and devices for providing illumination in an endoscopic imaging environment |
EP3492024A1 (en) * | 2017-11-29 | 2019-06-05 | Spartan Micro, Inc. | Systems for delivering intravascular implants |
KR102063535B1 (en) | 2018-05-29 | 2020-01-08 | 인제대학교 산학협력단 | Coil with adjustable length and how to detach-length the coil |
KR102084856B1 (en) * | 2018-08-29 | 2020-03-04 | 인제대학교 산학협력단 | Detachment length adjustable coil structure for embolization and instrument for embolization including the structure |
CN117715598A (en) * | 2021-07-07 | 2024-03-15 | 微仙美国有限公司 | Stretch-proof embolic coil |
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US20040002732A1 (en) * | 2002-06-27 | 2004-01-01 | Clifford Teoh | Stretch-resistant vaso-occlusive assembly with multiple detaching points |
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US5814062A (en) | 1994-12-22 | 1998-09-29 | Target Therapeutics, Inc. | Implant delivery assembly with expandable coupling/decoupling mechanism |
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US5989242A (en) | 1995-06-26 | 1999-11-23 | Trimedyne, Inc. | Therapeutic appliance releasing device |
US5911737A (en) | 1997-02-28 | 1999-06-15 | The Regents Of The University Of California | Microfabricated therapeutic actuators |
US6575965B1 (en) | 1997-03-06 | 2003-06-10 | The Regents Of The University Of California | Medical devices utilizing optical fibers for simultaneous power, communications and control |
US6478773B1 (en) | 1998-12-21 | 2002-11-12 | Micrus Corporation | Apparatus for deployment of micro-coil using a catheter |
US6500149B2 (en) | 1998-08-31 | 2002-12-31 | Deepak Gandhi | Apparatus for deployment of micro-coil using a catheter |
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US7740637B2 (en) | 2000-02-09 | 2010-06-22 | Micrus Endovascular Corporation | Apparatus and method for deployment of a therapeutic device using a catheter |
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US20060025801A1 (en) | 2004-07-30 | 2006-02-02 | Robert Lulo | Embolic device deployment system with filament release |
US7608089B2 (en) | 2004-12-22 | 2009-10-27 | Boston Scientific Scimed, Inc. | Vaso-occlusive device having pivotable coupling |
US20060271097A1 (en) | 2005-05-31 | 2006-11-30 | Kamal Ramzipoor | Electrolytically detachable implantable devices |
US7591833B2 (en) | 2005-06-30 | 2009-09-22 | Codman & Shurtleff, Inc. | Laser-based vascular occlusion device detachment system |
US7582101B2 (en) | 2006-02-28 | 2009-09-01 | Cordis Development Corporation | Heated mechanical detachment for delivery of therapeutic devices |
ES2627125T3 (en) | 2007-05-18 | 2017-07-26 | Stryker European Holdings I, Llc | Medical implant separation systems |
AU2009303677B2 (en) * | 2008-10-13 | 2014-04-24 | Stryker European Holdings I, Llc | Vaso-occlusive coil delivery system |
US20100160944A1 (en) | 2008-12-24 | 2010-06-24 | Boston Scientific Scimed, Inc. | Thermally detachable embolic assemblies |
EP2416712B1 (en) * | 2009-04-06 | 2018-12-19 | Stryker Corporation | Delivery wire for occlusive device delivery system |
WO2011130081A1 (en) | 2010-04-14 | 2011-10-20 | Microvention, Inc. | Implant delivery device |
-
2012
- 2012-03-30 US US13/436,236 patent/US8932318B2/en not_active Expired - Fee Related
-
2013
- 2013-03-22 CA CA2810090A patent/CA2810090A1/en not_active Abandoned
- 2013-03-27 AU AU2013202095A patent/AU2013202095B2/en not_active Ceased
- 2013-03-28 JP JP2013068491A patent/JP6173738B2/en not_active Expired - Fee Related
- 2013-03-28 CN CN201310103816.2A patent/CN103356259B/en not_active Expired - Fee Related
- 2013-03-29 KR KR1020130034164A patent/KR20130111421A/en not_active Application Discontinuation
- 2013-04-01 BR BRBR102013007796-8A patent/BR102013007796A2/en not_active Application Discontinuation
- 2013-04-02 ES ES14162781.0T patent/ES2621258T3/en active Active
- 2013-04-02 ES ES13162032.0T patent/ES2586861T3/en active Active
- 2013-04-02 EP EP13162032.0A patent/EP2644130B1/en not_active Not-in-force
- 2013-04-02 EP EP14162781.0A patent/EP2752163B1/en not_active Not-in-force
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US11051823B2 (en) * | 2016-06-01 | 2021-07-06 | DePuy Synthes Products, Inc. | Endovascular detachment system with flexible distal end and heater activated detachment |
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Also Published As
Publication number | Publication date |
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BR102013007796A2 (en) | 2015-06-16 |
KR20130111421A (en) | 2013-10-10 |
EP2644130A3 (en) | 2013-11-27 |
US8932318B2 (en) | 2015-01-13 |
JP2013212373A (en) | 2013-10-17 |
EP2752163A3 (en) | 2014-08-27 |
AU2013202095A1 (en) | 2013-10-17 |
JP6173738B2 (en) | 2017-08-02 |
CN103356259B (en) | 2017-03-01 |
ES2586861T3 (en) | 2016-10-19 |
AU2013202095B2 (en) | 2017-11-02 |
ES2621258T3 (en) | 2017-07-03 |
EP2752163A2 (en) | 2014-07-09 |
CN103356259A (en) | 2013-10-23 |
CA2810090A1 (en) | 2013-09-30 |
EP2644130B1 (en) | 2016-05-25 |
EP2752163B1 (en) | 2017-02-01 |
EP2644130A2 (en) | 2013-10-02 |
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