US20120157961A1 - Device and method for detecting chemical and biological agents - Google Patents
Device and method for detecting chemical and biological agents Download PDFInfo
- Publication number
- US20120157961A1 US20120157961A1 US12/031,860 US3186008A US2012157961A1 US 20120157961 A1 US20120157961 A1 US 20120157961A1 US 3186008 A US3186008 A US 3186008A US 2012157961 A1 US2012157961 A1 US 2012157961A1
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- US
- United States
- Prior art keywords
- tube portion
- freestanding tube
- antidote
- freestanding
- delivering
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Images
Classifications
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- G01F1/8468—Coriolis or gyroscopic mass flowmeters arrangements of measuring means, e.g., of measuring conduits vibrating measuring conduits
- G01F1/8472—Coriolis or gyroscopic mass flowmeters arrangements of measuring means, e.g., of measuring conduits vibrating measuring conduits having curved measuring conduits, i.e. whereby the measuring conduits' curved center line lies within a plane
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Definitions
- the present invention generally relates to fluid handling devices, their uses and operation. More particularly, this invention relates to a fluid handling device and method for sensing chemical and biological agents and preferably also treating a person exposed to such agents.
- Biochem biological and chemical
- Biochemical and chemical compounds can be detected through the use of absorption.
- film materials capable of selectively absorbing certain compounds find use in humidity, pH, glucose, bacteria, blood, cellular, pollution, poisons, gas and biotoxin sensors and detectors.
- biochem agents that might be used in an attack require immediate treatment to save the victim's life, with the medical response time making the difference between complete recovery and a permanent handicap or death.
- Making treatment available in the field and in time to be effectively used is desirable but difficult. Treatment on a remote battlefield, especially when fast-acting chemical agents are involved, can be particularly difficult since many affected personnel may be incapacitated.
- Commercial or military products or systems do not exist that can provide immediate and effective defense against an actual biochem attack.
- a portable rapid-response device were available as a first defense for individuals against chemical and biological terrorist attacks.
- Such a device would preferably be capable of detecting the type and amount of biochem agent.
- Such a device would also be preferably capable of selecting one or more appropriate antidotes, and precisely delivering appropriate amounts and concentrations of antidote(s) to the victim.
- the present invention provides a device and method capable of sensing the presence of biochem agents, and also preferably delivering precise amounts of one or more antidotes to treat a victim exposed to the agents.
- a device capable of detecting a chemical or biological agent includes a freestanding tube portion comprising an internal passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion.
- the device further includes means for flowing a fluidic sample through the freestanding tube portion, means for vibrating the freestanding tube portion at a resonant frequency thereof that varies with the combined density of the freestanding tube portion and any contents of its internal passage, means for sensing movement of the freestanding tube portion and producing an output signal based on the resonant frequency of the freestanding tube portion and indicative of accumulation of matter, and means for identifying the agent in the fluidic sample based on the accumulation of matter in the freestanding tube portion.
- a method performed by the detecting device involves detecting a chemical or biological agent by flowing a fluidic sample through a freestanding tube portion having an internal passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion, vibrating the tube portion at a resonant frequency thereof that varies with the combined density of the freestanding tube portion and contents of the internal passage, sensing movement of the freestanding tube portion to produce an output signal based on the resonant frequency of the freestanding tube portion and indicative of accumulation of the reaction product, and identifying the agent in the fluidic sample based on the accumulation of the reaction product in the freestanding tube portion.
- the detecting device is preferably used in combination with a device capable of delivering precise amounts of one or more antidotes to treat a victim that has been exposed to the biochem agents detected by the detecting device of this invention.
- the delivery device comprises a unit sufficiently small and light-weight to be carried by a person.
- the delivery device includes at least one antidote, means coupled to the at least one antidote for selecting the at least one antidote, means for delivering the at least one antidote into the body of the person, and means for communication between the selecting means and the delivering means.
- the detecting device preferably communicates with the selecting means of the delivery device and identifies the antidote(s) capable of counteracting the detected agent for the delivery device.
- each of the detecting and delivery devices makes use of a micromachined resonating tube of a type disclosed in U.S. Pat. No. 6,477,901 to Tadigadapa et al.
- a resonating tube is operated on the basis of the Coriolis effect to sense mass flow and density of a flowing fluid.
- a resonating tube is adapted to sense a change in the mass of the tube as a result of the matter that accumulates as a result of the presence of a chemical or biological agent drawn through the tube.
- the detecting and delivery devices described above are capable of being miniaturized and combined in a sufficiently small package to permit carrying by a person. As such, the devices are capable of being essential components of a portable rapid-response unit suitable for use as the first defense for individuals against chemical and biological attack. When used together, the detecting and delivery devices are capable of detecting the type and amount of biochem agent present, and then selecting and precisely delivering appropriate amounts and concentrations of the appropriate antidote(s) to the victim.
- FIG. 1 is a schematic of a device capable of detecting a chemical or biological agent in accordance with a first aspect of this invention.
- FIG. 2 is a schematic of a device capable of delivering an antidote for a chemical or biological agent in accordance with a second aspect of this invention.
- FIG. 3 is a schematic of a multi-antidote manifold for use with the device of FIG. 2 .
- FIGS. 4 and 5 represent a micromachined resonating tube suitable for use in the devices of FIGS. 1 and 2 .
- each device 10 and 50 makes use of a flow sensor 18 and 58 , respectively, of a type that makes miniaturization of the devices 10 and 50 possible.
- each flow sensor 18 and 58 contains one or more micromachined resonating tubes capable of measuring certain properties of a fluid using Coriolis force principles.
- a preferred flow sensor of this type is taught in U.S. Pat. No. 6,477,901 to Tadigadapa et al., incorporated herein by reference.
- a flow sensor 30 in accordance with Tadigadapa et al. and suitable for use in or as the flow sensors 18 and 58 is represented in FIGS. 4 and 5 .
- the sensor 30 is depicted as having a single micromachined resonating tube 32 fabricated on a substrate 36 , though any number of resonating tubes 32 could be fabricated on the substrate 36 and/or on any additional number of substrates.
- the flow sensor 30 represented in FIGS.
- the resonating tube 32 can be miniaturized by micromachining techniques to hold just a few nanoliters of fluid (1 to 1000 nL). As such, the resonating tube 32 represented in FIGS. 4 and 5 is ideally suited for use with the small, lightweight devices 10 and 50 of FIGS.
- the device 10 depicted in FIG. 1 is adapted for detecting the presence of a biochem agent, and preferably the type and concentration of the agent in a fluid being sampled.
- the fluid may be any liquid or gas through which a biochem may be delivered, such as air, water, biological fluids, as well as fluids in which a biochem agent may be detected in a victim, such as the victim's blood or urine.
- the detecting device 10 is represented as including an inlet 12 , a filter 14 , a pump 16 that operates to draw the fluid into the device 10 , the above-noted flow sensor 18 , and an outlet 20 through which the fluid exits the device 10 .
- the pump 16 is a suitable miniaturized fan or pump capable for moving the fluid intended for analysis.
- the fluid may be injected into the device 10 with a syringe or pipette (not shown).
- the filter 14 upstream of the pump 16 and sensor 18 is desirable and may be necessary to protect the sensor 18 from clogging or to assist in separating elements of the fluid, for example, separating white from red blood cells. Accordingly, the type of filter 14 employed by the device 10 will depend on the type of fluid being analyzed.
- the senor 18 preferably employs one or more micromachined resonating tubes 32 of the type disclosed in Tadigadapa et al.
- micromachining is a technique for forming very small elements by bulk etching a substrate (e.g., a silicon wafer), or by surface thin-film etching, the latter of which generally involves depositing a thin film (e.g., polysilicon or metal) on a sacrificial layer (e.g., oxide layer) on a substrate surface and then selectively removing portions of the sacrificial layer to free the deposited thin film.
- a thin film e.g., polysilicon or metal
- a sacrificial layer e.g., oxide layer
- suitable materials for the tube 32 include glass (e.g., quartz and Pyrex), ceramic, metal or a semiconductor, including micromachined silicon, germanium, Si/Ge and GaAs.
- FIGS. 4 and 5 show a suitable configuration for the tube 32 having a pair of legs and an interconnecting cross-member, yielding essentially a U-shaped freestanding tube portion 34 suspended above the surface of the substrate 36 . While a U-shaped freestanding tube portion 34 is shown, other shapes—both simpler and more complex—are within the scope of this invention.
- the tube portion 34 defines a continuous fluid passage 38 between an inlet and outlet 40 located on the opposite surface of the substrate 36 .
- micromachining technologies employed to fabricate the tube 32 enable the size of the tube 32 and its passage 38 to be extremely small, such as lengths of about 0.5 mm and cross-sectional areas of about 100 ⁇ m 2 , enabling the device 10 to process very small quantities of fluid.
- the freestanding tube portion 34 is preferably driven at resonance, with the resonant frequency being determined in part by its mechanical design (shape, size, construction and materials). Suitable frequencies are in the range of 1 kHz to over 100 kHz, depending on the particular fluid being analyzed. Under most circumstances, frequencies above 10 kHz, including ultrasonic frequencies (those in excess of 20 kHz), will be preferred.
- the amplitude of vibration is preferably adjusted through means used to vibrate the tube portion 34 .
- FIG. 4 shows an electrode 42 located beneath the tube portion 34 on the surface of the substrate 36 .
- the tube 32 serves as an electrode (e.g., is formed of doped silicon) that is capacitively coupled to the electrode 42 , enabling the electrode 42 to electrostatically drive the tube portion 34 .
- the tube 32 could be formed of a nonconductive material, and a separate electrode formed on the tube portion 34 opposite the electrode 42 for vibrating the tube portion 34 electrostatically.
- the tube portion 34 could be driven capacitively, piezoelectrically, piezoresistively, acoustically, ultrasonically, magnetically, optically, or by another actuation technique. Also shown in FIGS.
- sensing elements 44 for providing feedback to enable the vibration frequency and amplitude to be controlled with appropriate circuitry of a controller 24 , which may be located on the substrate 36 or on a separate substrate. While capacitive sensing is preferred, the sensing elements 44 could sense the proximity and motion of the tube portion 34 in any other suitable manner.
- FIG. 5 schematically represents the micromachined tube 32 as being enclosed by a cap 46 bonded or otherwise attached to the substrate 36 .
- the bond between the cap 46 and substrate 36 is hermetic, and the resulting enclosure formed between the substrate 36 and cap 46 is evacuated to enable the tube portion 34 to be driven efficiently at high Q values without damping.
- a suitable material for the cap 46 is silicon, allowing silicon-to-silicon bonding techniques to be used, though other cap materials and bonding techniques are possible and within the scope of the invention.
- the density of the fluid is proportional to the natural frequency of the fluid-filled vibrating tube portion 34 , such that controlling the vibration of the tube portion 34 to maintain a frequency at or near its resonant frequency will result in the vibration frequency changing if the density of the fluid flowing through the tube portion 34 changes.
- the detecting device 10 of FIG. 1 is not particularly concerned with the mass flow rate of a fluid through the tube portion 34 , but instead is interested in a change in mass that will occur over time during operation of the device 10 if the fluid being sampled contains a biochem agent.
- one or more interior wall surfaces of the tube portion 34 is coated or filled with a substance that absorbs, chemically reacts with, biologically reacts with, or otherwise causes the accumulation of matter when a specified biochem agent is present in the fluid flowing through the tube 32 .
- a substance is depicted in FIG.
- the film 48 could be a porous material that substantially fills the passage 38 , and the term “accumulation” is intended to encompass absorption, reactions, and any other mechanism that causes matter (e.g., the biochem agent, a reaction product thereof, etc.), to accumulate within the tube portion 34 .
- the mass of the resonant tube portion 34 also changes, generally increasing though possibly decreasing, depending on the relative densities of the fluid, the biochem agent, and the matter that accumulates in the tube portion 34 .
- the mass change causes a resonant frequency change in the tube portion 34 , enabling the sensor 18 to operate as a microscale that can be selective to a given chemical or biological agent.
- the sensor 18 can be fabricated to contain any number of tubes 32 , each dedicated to sensing the presence of a different biochem agent through the use of different substances for the films 48 within the tubes 32 .
- a change sensed in the resonant frequency of a particular tube 32 can be immediately recognized by the device 10 as indicating the presence in the sampled fluid of the agent for which the film 48 within the tube 32 is selective.
- the rate at which the resonant frequency of a tube 32 changes is also potentially of interest as indicating the concentration of the agent in the sampled fluid.
- the controller 24 can include clock circuitry against which changes in resonant frequency (corresponding to accumulation of matter within the tube 32 and therefore the presence of agents in the sampled fluid) can be monitored.
- the detecting device 10 has application for detecting the presence of a wide variety of biochemical agents, including chemical warfare agents (mustard gas, cyanide, lewisite, nerve agents, etc.) and biological warfare agents (anthrax, botulism, Brucellosis, plague, Q-fever, etc.).
- biochemical agents including chemical warfare agents (mustard gas, cyanide, lewisite, nerve agents, etc.) and biological warfare agents (anthrax, botulism, Brucellosis, plague, Q-fever, etc.).
- the device 10 can also be employed to detect a variety of other potentially harmful agents, including a variety of bacteria and viruses, dust, soot, organic solvents, drugs, explosive elements, poisons, gases, biotoxins, tainted food, water and air pollution, as well as the presence and/or properties of other chemicals, compounds, and particles of potential interest, such as humidity, pH, glucose, blood and its components, antibodies, cells, enzymes, DNA, proteins, white blood cells, urine and its components, etc. If bacteria detection is desired, the device 10 may require the capability of accumulating and incubating enough cells in the tube 32 for detection. However, since the tube 32 can be fabricated to have a volume of only several nanoliters, the invention offers the advantage of being able to detect the presence of a bacteria with only a few cells.
- Liquid and gaseous deposition techniques can be employed to deposit the film 48 , such as by injecting the absorbent or chemically/biologically reactive material into the tube 32 and allowing the material to dry to form the accumulation film 48 .
- the performance of the tube 32 formed by silicon micromachining can be enhanced with several fabrication and design techniques. For example, single or multiple layers can be deposited or formed on the inner surfaces of the tube passage 38 to provide a surface that is more chemically reactive than the material of which the tube 32 is formed, for example, silicon or silicon oxide.
- a metal such as gold can be deposited and then coated with a film 48 formed by a layer of thiolated single-stranded DNA to detect complementary DNA strands.
- platinum has been shown to attract proteins.
- Metal silicides can be deposited to improve adhesion of platinum and other reactive metals to a silicon tube 32 . Furthermore, one or more polymer layers can be applied before application of a reaction-promoting layer (if present) and the film 48 to promote adhesion of these layers to tube surfaces formed of silicon, silicon oxide, silicon nitride, metal, metal silicide, etc.
- the sensitivity of the tube portion 34 to mass change generally increases as the thickness of the film 48 increases relative to the tube wall thickness. Therefore, a relatively thick film 48 and/or relatively thin tube walls are generally desirable.
- the tube 32 can be isotropically thinned with a plasma or wet etch after release of the tube portion 34 during the fabrication process. Nano-technology can also be used for the fabrication of the tube 32 to further increase the sensitivity of the sensor 30 .
- the controller 24 may include a temperature control element (not shown) to sense the temperature of the flow sensor 18 and thereby achieve higher accuracy of chemical and biological detection with the device 10 . Temperature control can also be used to improve the performance and reduce the damage to biologic compounds. As represented in FIG. 1 , the controller 24 preferably controls the pump 16 , the sensor 18 and its resonating tube portion 34 , and any temperature or other compensating devices. Furthermore, these devices are shown as being powered by an on-board battery 22 or other power storage device. Suitable devices for this purpose are known and therefore will not be discussed in any detail here.
- the sensor 18 can comprise arrays of the flow sensor 30 depicted in FIGS. 4 and 5 , which in turn may comprise any number of resonating tubes 32 .
- the device 10 is capable of detecting many different chemicals, cells and/or biotoxins.
- Multiple sensors 18 and digital logic with memory can be employed to reduce the incidence of false positive chemical identifications occurring.
- Operating inputs 26 to the controller 24 and alarms and data output 28 from the controller 24 enable the device 10 in be used as a stand-alone unit carried by an individual for personal protection from biochem agents, or used as a unit for wireless communication with a remote central control system 29 .
- the device 10 can perform widely dispersed environmental monitoring or be used as a medical implant to check on internal chemical activity within the individual.
- the invention is capable of continuous monitoring of air and water surrounding an individual carrying the device 10 , or can be implanted in an individual to continuously monitor urine, blood, or other bodily fluids, or placed in various other environments to monitor the presence of agents within air systems, water systems, industrial chemicals, etc.
- a significant advantage of the invention is that, because of the miniaturized sensor 18 , the detecting device 10 can be small, portable and relatively inexpensive, especially when fabricated by micromachining technology to yield what is known as a microelectromechanical system (MEMS). It is foreseeable that the cost of the device 10 can be sufficiently low to render the device 10 disposable. Alternatively, the sensor 18 can be recycled after the film 48 becomes saturated. For example, heat and/or an aggressive detergent or solvent could be flushed through the tube 32 to strip the inner walls of the film 48 and the matter that has accumulated within the tube 32 as a result of absorption and/or reaction with a biochem agent. After cleaning, the inner walls of the tube 32 can be recoated if needed or desired. In view of the above, device size, batch fabrication and recycling can all contribute to reducing the cost of sensing biochem agents with the device 10 .
- MEMS microelectromechanical system
- the delivery device 50 represented in FIG. 2 is adapted for delivering an antidote or other appropriate treatment to an individual, such as through a needle (not shown) or other device capable of delivering an antidote in an appropriate manner.
- a needle not shown
- an antidote in an appropriate manner.
- Notable examples include a subdermal patch or intramuscularly (IM) or intravenously (IV) delivery through an IM/IV line, though other delivery methods are possible, e.g., intra-arterially, subcutaneously, intraperitoneally or intrathecally.
- the delivery device 50 is particularly well suited for use in combination with the detecting device 10 of FIG. 1 , though the devices 10 and 50 could also be used separately and independently.
- the devices 10 and 50 are capable of being part of a single unit that can be carried by a person to sense chemical and biological warfare agents and deliver an appropriate antidote, preferably from an inventory of multiple drugs contained in the device 50 .
- the device 50 is represented in FIG. 2 as including a reservoir 52 suitable for containing one or more antidotes, a valve 54 , a pump 56 , the previously-described flow sensor 58 , and an outlet 60 through which the antidote exits the device 50 and is delivered to the individual. While the reservoir 52 and pump 56 are represented as separate components, their functions could be combined in a single component, such as by fabricating the reservoir 52 of one or more elastomeric bladders that contain the antidotes under pressure. As with the detecting device 10 of FIG. 1 , the delivery device 50 includes a controller 64 that communicates with the flow sensor 58 to control the operation of its resonating tube 32 .
- the controller 64 also preferably communicates with the valve 54 and pump 56 to allow flow through the device 50 to be initiated when treatment is required in response to detection of a harmful agent, and stopped when sufficient antidote has been delivered for the type and amount of agent detected. Also similar to the detecting device 10 , the delivery device 50 is equipped with a battery 62 for powering the valve 54 , pump 56 , flow sensor 58 and controller 64 . Furthermore, operating inputs 66 to the controller 64 and alarms and data output 68 from the controller 64 enable the operation of the device 50 to be observed and controlled by the user.
- the sensor 18 preferably employs one or more micromachined resonating tubes 32 of the type disclosed in Tadigadapa et al.
- Resonating tube flow sensors of the type disclosed by Tad igadapa et al. are preferred in view of their very small size and ability to precisely measure extremely small amounts of fluids, in contrast to prior art Coriolis-type flow sensors.
- the flow sensor 58 of FIG. 2 employs a resonating tube of the type shown in FIGS. 4 and 5
- flow rate measurement accuracies of under +/ ⁇ 1% can be achieved, in contrast to conventional infusion pumps whose accuracies can range from about +/ ⁇ 15% for volumetric pumps down to +/ ⁇ 3% for syringe pumps.
- the flow sensor of Tadigadapa et al. is able to sense the extremely low flow rates (e.g., less than 0.5 ml/hr) that can be necessary when administering an antidote.
- Another advantage is that use of an electrostatic drive and capacitive sensing (as represented in FIGS. 4 and 5 ) minimizes the power requirements of the sensor 58 . Accordingly, the flow sensor taught by Tadigadapa et al. is ideal for achieving the high dosage accuracy, reliability, small size, biocompatibility, drug compatibility, and low power requirements needed for the device 50 of this invention.
- FIG. 3 depicts a manifold system 70 to which a number of cartridges 72 are mounted to provide a multi-antidote infusion system that combines the reservoir 52 , valve 54 , and sensor 58 of FIG. 2 in a single assembly.
- the manifold 70 comprises a fluid manifold 74 and an electrical “manifold” or power bus 76 , to which each cartridge 72 is fluidically and electrically connected through connectors 78 and 80 , respectively.
- the manifold system 70 can be fabricated to carry a sensor 58 and valve 54 dedicated to each cartridge 72 . Since the manifold system 70 is modular, the sizes of the cartridges 72 can vary to accommodate different dosing requirements.
- the power bus 76 provides power to the sensors 58 and valves 54 , relays input and output signals between the controller 64 (not shown) and the sensors 58 , and relays input signals from the controller 64 to the valves 54 .
- the manifold system 70 depicted in FIG. 3 is notably equipped with sufficient cartridges 72 to treat the following eleven biochem agents that have antidotes and pose a serious threat in the hands of terrorists and rogue states: sarin, VX, tabun, soman, cyanide, lewisite ( ⁇ -chlorovinyldichloroarsine), anthrax, brucellosis, bubonic plague, Q fever, and botulism.
- the manifold system 70 is shown as being equipped with eight cartridges 72 that can contain atropine and 2-PAM-CI for nerve agents, botulism antitoxin, tetracycline and doxycycline for the initial treatment of anthrax, brucellosis, Q-fever and the plague, BAL or dimercaprol for lewisite and sodium nitrile followed by sodium thiosulphate for cyanide poisoning. Subsets of these drug combinations or alternate drugs could also be utilized in the manifold system 70 .
- Delivery of one or more antidotes can be initiated with the controller 64 either through manual input by the user, a radio signal from a remote central location (e.g., the control system 29 of FIG. 1 ), or in response to one or more detecting devices (e.g., the detecting device 10 of FIG. 1 ) carried on the person or placed in the local vicinity.
- the programmability of the device 50 can include, but is not limited to, which antidote or combinations of antidotes should be delivered, the dosage, and the timing of the delivery (e.g. continuous or intermittent) for a variety of treatment regimes.
- the programmability of the device 50 also preferably allows the user to preprogram his or her body weight into the device 50 to improve self-treatment and safety.
- the device 50 can be configured to offer other advantages and functions.
- the ability to measure antidote density can be used to prevent deliver of the wrong antidote or those that are spoiled or contain air bubbles or inclusions.
- Other functionalities that can be combined with the device 50 include indicating the location of the individual (e.g., through GPS (global positioning system)), broadcasting an alert signal to a remote center or others equipped with similar delivery devices 50 if delivery of an antidote is commenced in response to an attack, monitoring of the individual's biological functions (e.g., heart beat), sending such biological information to a remote center or another individual, etc.
- the device 50 including its valve 54 , pump 56 , sensor 58 , and injection device
- such additional components can be fabricated by micromachining to yield a fully integrated system that is small, low-power, rugged and biocompatible at high production volumes.
- a needle connected to the device 50 in his or her body and then activate the device 50 to allow the device 50 to deliver the appropriate antidote combination and dosage based on the type and concentration of agent sensed.
- a needle or catheter can be pre-inserted so that the device 50 can inject the appropriate antidote combination and dosage without any (or minimal) direct input or action from the user.
- a remote central detection system e.g., making use of the detecting device 10
- each device 50 When an alert from the central detection system is received, each device 50 automatically selects the appropriate antidote(s) and delivers the antidote(s) at the appropriate dose and delivery timing to the individual wearing the device 50 .
- each device 50 has a keypad (not shown) to interface with the controller 64 .
- the user can punch in the appropriate code to cause the device 50 to select and deliver the correct antidote.
- the detecting device 10 and the delivery device 50 are contained in a single portable unit, so that the unit contains all of the components necessary to sense and automatically respond to a chemical or biological threat.
- the present invention provides a biochem detecting device 10 and an antidote delivery device 50 that can be combined into a single unit as a first defense for individuals against a chemical and/or biological attack.
- the detecting device 10 and delivery device 50 provide for the automatic detection of the type and amount of biochem agent present, selection of an appropriate antidote combination from multiple reservoirs, preparation and mixing of the appropriate antidotes at the correct concentration, and delivery of such antidote(s) with great accuracy.
- the invention provides a small, portable, rapid-response bio-protector that can be carried as standard equipment by a soldier or other at-risk personnel for rapid treatment during an attack without the intervention of a medical professional. If the treatment is carried out automatically, the invention has the further advantage of being capable of precise dose control and repeated, timed injections as may be necessary.
Abstract
A device and method capable of sensing the presence of biochem agents, and preferably also capable of delivering precise amounts of one or more antidotes to treat a victim exposed to the agents. The device includes a freestanding tube portion having an internal passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion when a fluid drawn through the tube portion contains the agent. When vibrated at resonance, the resonant frequency of the tube portion is indicative of the accumulation of matter and thereby the presence of the agent to which the substance is selective. The device then preferably delivers precise amounts of one or more appropriate antidotes to treat the victim. The device is a sufficiently small and lightweight unit to permit being carried by an individual.
Description
- This is a division patent application of co-pending U.S. patent application Ser. No. 10/709,782, filed May 27, 2004, which claims the benefit of U.S. Provisional Application No. 60/473,383, filed May 27, 2003. The contents of these prior applications are incorporated herein by reference.
- The present invention generally relates to fluid handling devices, their uses and operation. More particularly, this invention relates to a fluid handling device and method for sensing chemical and biological agents and preferably also treating a person exposed to such agents.
- The threat of biological and chemical (biochem) attack from terrorists and rogue states has increased in recent years. Biochem threats particularly put military personnel, law enforcement, emergency response, first responders, and postal workers at risk. While not all biochem agents have antidotes, a significant percentage does. For example, antidotes and treatments exist for sarin, VX, tabun, soman, cyanide, lewisite (β-chlorovinyldichloroarsine), anthrax, brucellosis, bubonic plague, Q fever, and botulism.
- Biochemical and chemical compounds can be detected through the use of absorption. For example, film materials capable of selectively absorbing certain compounds find use in humidity, pH, glucose, bacteria, blood, cellular, pollution, poisons, gas and biotoxin sensors and detectors. However, many biochem agents that might be used in an attack require immediate treatment to save the victim's life, with the medical response time making the difference between complete recovery and a permanent handicap or death. Making treatment available in the field and in time to be effectively used is desirable but difficult. Treatment on a remote battlefield, especially when fast-acting chemical agents are involved, can be particularly difficult since many affected personnel may be incapacitated. Commercial or military products or systems do not exist that can provide immediate and effective defense against an actual biochem attack.
- In view of the above, it would be desirable if a portable rapid-response device were available as a first defense for individuals against chemical and biological terrorist attacks. Such a device would preferably be capable of detecting the type and amount of biochem agent. Such a device would also be preferably capable of selecting one or more appropriate antidotes, and precisely delivering appropriate amounts and concentrations of antidote(s) to the victim. Finally, it would be advantageous if the number of separate components required to perform these functions could be minimized while maintaining or improving the precision by which these functions are performed.
- The present invention provides a device and method capable of sensing the presence of biochem agents, and also preferably delivering precise amounts of one or more antidotes to treat a victim exposed to the agents.
- According to one aspect of the invention, a device capable of detecting a chemical or biological agent includes a freestanding tube portion comprising an internal passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion. The device further includes means for flowing a fluidic sample through the freestanding tube portion, means for vibrating the freestanding tube portion at a resonant frequency thereof that varies with the combined density of the freestanding tube portion and any contents of its internal passage, means for sensing movement of the freestanding tube portion and producing an output signal based on the resonant frequency of the freestanding tube portion and indicative of accumulation of matter, and means for identifying the agent in the fluidic sample based on the accumulation of matter in the freestanding tube portion.
- In view of the above, a method performed by the detecting device involves detecting a chemical or biological agent by flowing a fluidic sample through a freestanding tube portion having an internal passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion, vibrating the tube portion at a resonant frequency thereof that varies with the combined density of the freestanding tube portion and contents of the internal passage, sensing movement of the freestanding tube portion to produce an output signal based on the resonant frequency of the freestanding tube portion and indicative of accumulation of the reaction product, and identifying the agent in the fluidic sample based on the accumulation of the reaction product in the freestanding tube portion.
- According to a second aspect of the invention, the detecting device is preferably used in combination with a device capable of delivering precise amounts of one or more antidotes to treat a victim that has been exposed to the biochem agents detected by the detecting device of this invention. The delivery device comprises a unit sufficiently small and light-weight to be carried by a person. The delivery device includes at least one antidote, means coupled to the at least one antidote for selecting the at least one antidote, means for delivering the at least one antidote into the body of the person, and means for communication between the selecting means and the delivering means. The detecting device preferably communicates with the selecting means of the delivery device and identifies the antidote(s) capable of counteracting the detected agent for the delivery device.
- In a preferred embodiment of the invention, each of the detecting and delivery devices makes use of a micromachined resonating tube of a type disclosed in U.S. Pat. No. 6,477,901 to Tadigadapa et al. According to Tadigadapa et al., a resonating tube is operated on the basis of the Coriolis effect to sense mass flow and density of a flowing fluid. In the present invention, a resonating tube is adapted to sense a change in the mass of the tube as a result of the matter that accumulates as a result of the presence of a chemical or biological agent drawn through the tube.
- The detecting and delivery devices described above are capable of being miniaturized and combined in a sufficiently small package to permit carrying by a person. As such, the devices are capable of being essential components of a portable rapid-response unit suitable for use as the first defense for individuals against chemical and biological attack. When used together, the detecting and delivery devices are capable of detecting the type and amount of biochem agent present, and then selecting and precisely delivering appropriate amounts and concentrations of the appropriate antidote(s) to the victim.
- Other objects and advantages of this invention will be better appreciated from the following detailed description.
-
FIG. 1 is a schematic of a device capable of detecting a chemical or biological agent in accordance with a first aspect of this invention. -
FIG. 2 is a schematic of a device capable of delivering an antidote for a chemical or biological agent in accordance with a second aspect of this invention. -
FIG. 3 is a schematic of a multi-antidote manifold for use with the device ofFIG. 2 . -
FIGS. 4 and 5 represent a micromachined resonating tube suitable for use in the devices ofFIGS. 1 and 2 . - With reference to
FIGS. 1 and 2 , twodevices devices device flow sensor devices flow sensor - A
flow sensor 30 in accordance with Tadigadapa et al. and suitable for use in or as theflow sensors FIGS. 4 and 5 . Briefly, thesensor 30 is depicted as having a single micromachinedresonating tube 32 fabricated on asubstrate 36, though any number ofresonating tubes 32 could be fabricated on thesubstrate 36 and/or on any additional number of substrates. According to Tadigadapa et al., theflow sensor 30 represented inFIGS. 4 and 5 can be used to measure the flow rate of a fluid flowing through afreestanding portion 34 of itstube 32 by sensing the degree to which thefreestanding portion 34 deflects (twists) when vibrated, and can be used to measure the density of the fluid by sensing changes in the resonant frequency of the freestandingportion 34. When packaged in a vacuum, thesensor 30 is capable of producing a high Q signal. Furthermore, theresonating tube 32 can be miniaturized by micromachining techniques to hold just a few nanoliters of fluid (1 to 1000 nL). As such, theresonating tube 32 represented inFIGS. 4 and 5 is ideally suited for use with the small,lightweight devices FIGS. 1 and 2 , and thedevices sensors such tubes 32. However, it is foreseeable that other miniaturized fluid-handling devices could be developed by which biochem agents can be detected and the appropriate antidote(s) delivered in accordance with this invention. - The
device 10 depicted inFIG. 1 is adapted for detecting the presence of a biochem agent, and preferably the type and concentration of the agent in a fluid being sampled. The fluid may be any liquid or gas through which a biochem may be delivered, such as air, water, biological fluids, as well as fluids in which a biochem agent may be detected in a victim, such as the victim's blood or urine. The detectingdevice 10 is represented as including aninlet 12, afilter 14, apump 16 that operates to draw the fluid into thedevice 10, the above-notedflow sensor 18, and anoutlet 20 through which the fluid exits thedevice 10. Thepump 16 is a suitable miniaturized fan or pump capable for moving the fluid intended for analysis. Alternatively, some applications may allow the fluid to be injected into thedevice 10 with a syringe or pipette (not shown). Thefilter 14 upstream of thepump 16 andsensor 18 is desirable and may be necessary to protect thesensor 18 from clogging or to assist in separating elements of the fluid, for example, separating white from red blood cells. Accordingly, the type offilter 14 employed by thedevice 10 will depend on the type of fluid being analyzed. - As discussed above, the
sensor 18 preferably employs one or more micromachinedresonating tubes 32 of the type disclosed in Tadigadapa et al. As used herein, micromachining is a technique for forming very small elements by bulk etching a substrate (e.g., a silicon wafer), or by surface thin-film etching, the latter of which generally involves depositing a thin film (e.g., polysilicon or metal) on a sacrificial layer (e.g., oxide layer) on a substrate surface and then selectively removing portions of the sacrificial layer to free the deposited thin film. Accordingly, suitable materials for thetube 32 include glass (e.g., quartz and Pyrex), ceramic, metal or a semiconductor, including micromachined silicon, germanium, Si/Ge and GaAs.FIGS. 4 and 5 show a suitable configuration for thetube 32 having a pair of legs and an interconnecting cross-member, yielding essentially a U-shapedfreestanding tube portion 34 suspended above the surface of thesubstrate 36. While a U-shapedfreestanding tube portion 34 is shown, other shapes—both simpler and more complex—are within the scope of this invention. Thetube portion 34 defines acontinuous fluid passage 38 between an inlet andoutlet 40 located on the opposite surface of thesubstrate 36. As previously noted, micromachining technologies employed to fabricate thetube 32 enable the size of thetube 32 and itspassage 38 to be extremely small, such as lengths of about 0.5 mm and cross-sectional areas of about 100 μm2, enabling thedevice 10 to process very small quantities of fluid. - The
freestanding tube portion 34 is preferably driven at resonance, with the resonant frequency being determined in part by its mechanical design (shape, size, construction and materials). Suitable frequencies are in the range of 1 kHz to over 100 kHz, depending on the particular fluid being analyzed. Under most circumstances, frequencies above 10 kHz, including ultrasonic frequencies (those in excess of 20 kHz), will be preferred. The amplitude of vibration is preferably adjusted through means used to vibrate thetube portion 34. For this purpose,FIG. 4 shows anelectrode 42 located beneath thetube portion 34 on the surface of thesubstrate 36. In the embodiment shown, thetube 32 serves as an electrode (e.g., is formed of doped silicon) that is capacitively coupled to theelectrode 42, enabling theelectrode 42 to electrostatically drive thetube portion 34. However, it is foreseeable that thetube 32 could be formed of a nonconductive material, and a separate electrode formed on thetube portion 34 opposite theelectrode 42 for vibrating thetube portion 34 electrostatically. Furthermore, thetube portion 34 could be driven capacitively, piezoelectrically, piezoresistively, acoustically, ultrasonically, magnetically, optically, or by another actuation technique. Also shown inFIGS. 4 and 5 are sensingelements 44 for providing feedback to enable the vibration frequency and amplitude to be controlled with appropriate circuitry of acontroller 24, which may be located on thesubstrate 36 or on a separate substrate. While capacitive sensing is preferred, thesensing elements 44 could sense the proximity and motion of thetube portion 34 in any other suitable manner. -
FIG. 5 schematically represents themicromachined tube 32 as being enclosed by acap 46 bonded or otherwise attached to thesubstrate 36. In a preferred embodiment, the bond between thecap 46 andsubstrate 36 is hermetic, and the resulting enclosure formed between thesubstrate 36 andcap 46 is evacuated to enable thetube portion 34 to be driven efficiently at high Q values without damping. A suitable material for thecap 46 is silicon, allowing silicon-to-silicon bonding techniques to be used, though other cap materials and bonding techniques are possible and within the scope of the invention. - In Tadigadapa et al., monitoring the frequency of vibration of the
tube portion 34 while a fluid flows through thepassage 38 enables the density and mass flow rate of the fluid to be measured. As fluid flows through thetube portion 34 while thetube portion 34 is vibrated at resonance, thetube portion 34 twists under the influence of the Coriolis effect. As explained in Tadigadapa et al., the degree to which thetube portion 34 twists (deflects) when vibrated can be correlated to the mass flow rate of the fluid flowing through thetube portion 34 on the basis of the change in the amplitude of a secondary resonant vibration mode. The density of the fluid is proportional to the natural frequency of the fluid-filled vibratingtube portion 34, such that controlling the vibration of thetube portion 34 to maintain a frequency at or near its resonant frequency will result in the vibration frequency changing if the density of the fluid flowing through thetube portion 34 changes. - In contrast to Tadigadapa et al., the detecting
device 10 ofFIG. 1 is not particularly concerned with the mass flow rate of a fluid through thetube portion 34, but instead is interested in a change in mass that will occur over time during operation of thedevice 10 if the fluid being sampled contains a biochem agent. For this purpose, one or more interior wall surfaces of thetube portion 34 is coated or filled with a substance that absorbs, chemically reacts with, biologically reacts with, or otherwise causes the accumulation of matter when a specified biochem agent is present in the fluid flowing through thetube 32. Such a substance is depicted inFIG. 2 as afilm 48, hereinafter theaccumulation film 48, though it is to be understood that thefilm 48 could be a porous material that substantially fills thepassage 38, and the term “accumulation” is intended to encompass absorption, reactions, and any other mechanism that causes matter (e.g., the biochem agent, a reaction product thereof, etc.), to accumulate within thetube portion 34. As accumulation takes place, the mass of theresonant tube portion 34 also changes, generally increasing though possibly decreasing, depending on the relative densities of the fluid, the biochem agent, and the matter that accumulates in thetube portion 34. The mass change causes a resonant frequency change in thetube portion 34, enabling thesensor 18 to operate as a microscale that can be selective to a given chemical or biological agent. Thesensor 18 can be fabricated to contain any number oftubes 32, each dedicated to sensing the presence of a different biochem agent through the use of different substances for thefilms 48 within thetubes 32. In this manner, a change sensed in the resonant frequency of aparticular tube 32 can be immediately recognized by thedevice 10 as indicating the presence in the sampled fluid of the agent for which thefilm 48 within thetube 32 is selective. The rate at which the resonant frequency of atube 32 changes is also potentially of interest as indicating the concentration of the agent in the sampled fluid. For this purpose, thecontroller 24 can include clock circuitry against which changes in resonant frequency (corresponding to accumulation of matter within thetube 32 and therefore the presence of agents in the sampled fluid) can be monitored. - The detecting
device 10 has application for detecting the presence of a wide variety of biochemical agents, including chemical warfare agents (mustard gas, cyanide, lewisite, nerve agents, etc.) and biological warfare agents (anthrax, botulism, Brucellosis, plague, Q-fever, etc.). Thedevice 10 can also be employed to detect a variety of other potentially harmful agents, including a variety of bacteria and viruses, dust, soot, organic solvents, drugs, explosive elements, poisons, gases, biotoxins, tainted food, water and air pollution, as well as the presence and/or properties of other chemicals, compounds, and particles of potential interest, such as humidity, pH, glucose, blood and its components, antibodies, cells, enzymes, DNA, proteins, white blood cells, urine and its components, etc. If bacteria detection is desired, thedevice 10 may require the capability of accumulating and incubating enough cells in thetube 32 for detection. However, since thetube 32 can be fabricated to have a volume of only several nanoliters, the invention offers the advantage of being able to detect the presence of a bacteria with only a few cells. - Liquid and gaseous deposition techniques can be employed to deposit the
film 48, such as by injecting the absorbent or chemically/biologically reactive material into thetube 32 and allowing the material to dry to form theaccumulation film 48. The performance of thetube 32 formed by silicon micromachining can be enhanced with several fabrication and design techniques. For example, single or multiple layers can be deposited or formed on the inner surfaces of thetube passage 38 to provide a surface that is more chemically reactive than the material of which thetube 32 is formed, for example, silicon or silicon oxide. For example, a metal such as gold can be deposited and then coated with afilm 48 formed by a layer of thiolated single-stranded DNA to detect complementary DNA strands. Furthermore, platinum has been shown to attract proteins. Metal silicides can be deposited to improve adhesion of platinum and other reactive metals to asilicon tube 32. Furthermore, one or more polymer layers can be applied before application of a reaction-promoting layer (if present) and thefilm 48 to promote adhesion of these layers to tube surfaces formed of silicon, silicon oxide, silicon nitride, metal, metal silicide, etc. - The sensitivity of the
tube portion 34 to mass change generally increases as the thickness of thefilm 48 increases relative to the tube wall thickness. Therefore, a relativelythick film 48 and/or relatively thin tube walls are generally desirable. For the latter, thetube 32 can be isotropically thinned with a plasma or wet etch after release of thetube portion 34 during the fabrication process. Nano-technology can also be used for the fabrication of thetube 32 to further increase the sensitivity of thesensor 30. - Since the densities of materials vary with temperature, temperature control is often used to manufacture highly accurate density meters of the prior art, such as thermoelectrically-controlled resonant temperature systems. Because the densities of the tube material, coatings, and analyzed fluids are all subject to change with temperature, the
controller 24 may include a temperature control element (not shown) to sense the temperature of theflow sensor 18 and thereby achieve higher accuracy of chemical and biological detection with thedevice 10. Temperature control can also be used to improve the performance and reduce the damage to biologic compounds. As represented inFIG. 1 , thecontroller 24 preferably controls thepump 16, thesensor 18 and its resonatingtube portion 34, and any temperature or other compensating devices. Furthermore, these devices are shown as being powered by an on-board battery 22 or other power storage device. Suitable devices for this purpose are known and therefore will not be discussed in any detail here. - As noted above, the
sensor 18 can comprise arrays of theflow sensor 30 depicted inFIGS. 4 and 5 , which in turn may comprise any number of resonatingtubes 32. By providingmultiple tubes 32 with different absorbent/reactive films 48, thedevice 10 is capable of detecting many different chemicals, cells and/or biotoxins.Multiple sensors 18 and digital logic with memory can be employed to reduce the incidence of false positive chemical identifications occurring.Operating inputs 26 to thecontroller 24 and alarms anddata output 28 from thecontroller 24 enable thedevice 10 in be used as a stand-alone unit carried by an individual for personal protection from biochem agents, or used as a unit for wireless communication with a remotecentral control system 29. In the latter embodiment, thedevice 10 can perform widely dispersed environmental monitoring or be used as a medical implant to check on internal chemical activity within the individual. As such, the invention is capable of continuous monitoring of air and water surrounding an individual carrying thedevice 10, or can be implanted in an individual to continuously monitor urine, blood, or other bodily fluids, or placed in various other environments to monitor the presence of agents within air systems, water systems, industrial chemicals, etc. - A significant advantage of the invention is that, because of the
miniaturized sensor 18, the detectingdevice 10 can be small, portable and relatively inexpensive, especially when fabricated by micromachining technology to yield what is known as a microelectromechanical system (MEMS). It is foreseeable that the cost of thedevice 10 can be sufficiently low to render thedevice 10 disposable. Alternatively, thesensor 18 can be recycled after thefilm 48 becomes saturated. For example, heat and/or an aggressive detergent or solvent could be flushed through thetube 32 to strip the inner walls of thefilm 48 and the matter that has accumulated within thetube 32 as a result of absorption and/or reaction with a biochem agent. After cleaning, the inner walls of thetube 32 can be recoated if needed or desired. In view of the above, device size, batch fabrication and recycling can all contribute to reducing the cost of sensing biochem agents with thedevice 10. - In an investigation leading up to the invention, water was injected into a flow sensor of the type represented in
FIGS. 4 and 5 . In response, the resonant frequency of the tube dropped from about 11 KHz to about 8.6 KHz. After removing the water with compressed air, the frequency initially increased to about 10.950 KHz and then gradually continued to rise, indicating that a film of water remained on the inside of the tube. In view of this observation, it was evident that the sensor was capable of sensing the presence of a very fine film that had accumulated within the tube after flow had been discontinued and the bulk of the water removed. Heating the tube and pulling a vacuum inside the tube eventually restored the resonant frequency of the tube to the original 11 KHz. Similar sensitivities to the accumulation of other materials have also been observed, such as when testing oils. From these observations, it was concluded that the inner surfaces of a resonating tube could be manufactured to intentionally and selectively absorb agents (e.g., biochem agents) to enable the device to operate as a sensor or microscale for such agents. - As previously noted, the
delivery device 50 represented inFIG. 2 is adapted for delivering an antidote or other appropriate treatment to an individual, such as through a needle (not shown) or other device capable of delivering an antidote in an appropriate manner. Notable examples include a subdermal patch or intramuscularly (IM) or intravenously (IV) delivery through an IM/IV line, though other delivery methods are possible, e.g., intra-arterially, subcutaneously, intraperitoneally or intrathecally. Thedelivery device 50 is particularly well suited for use in combination with the detectingdevice 10 ofFIG. 1 , though thedevices devices device 50. - The
device 50 is represented inFIG. 2 as including areservoir 52 suitable for containing one or more antidotes, avalve 54, apump 56, the previously-describedflow sensor 58, and anoutlet 60 through which the antidote exits thedevice 50 and is delivered to the individual. While thereservoir 52 and pump 56 are represented as separate components, their functions could be combined in a single component, such as by fabricating thereservoir 52 of one or more elastomeric bladders that contain the antidotes under pressure. As with the detectingdevice 10 ofFIG. 1 , thedelivery device 50 includes acontroller 64 that communicates with theflow sensor 58 to control the operation of its resonatingtube 32. Thecontroller 64 also preferably communicates with thevalve 54 and pump 56 to allow flow through thedevice 50 to be initiated when treatment is required in response to detection of a harmful agent, and stopped when sufficient antidote has been delivered for the type and amount of agent detected. Also similar to the detectingdevice 10, thedelivery device 50 is equipped with abattery 62 for powering thevalve 54, pump 56,flow sensor 58 andcontroller 64. Furthermore, operatinginputs 66 to thecontroller 64 and alarms anddata output 68 from thecontroller 64 enable the operation of thedevice 50 to be observed and controlled by the user. - As discussed above, the
sensor 18 preferably employs one or moremicromachined resonating tubes 32 of the type disclosed in Tadigadapa et al. Resonating tube flow sensors of the type disclosed by Tad igadapa et al. are preferred in view of their very small size and ability to precisely measure extremely small amounts of fluids, in contrast to prior art Coriolis-type flow sensors. For example, if theflow sensor 58 ofFIG. 2 employs a resonating tube of the type shown inFIGS. 4 and 5 , flow rate measurement accuracies of under +/−1% can be achieved, in contrast to conventional infusion pumps whose accuracies can range from about +/−15% for volumetric pumps down to +/−3% for syringe pumps. While the high cost and the high flow rate requirements for prior art Coriolis-type flow sensors have restricted their use in the drug delivery arena, the flow sensor of Tadigadapa et al. is able to sense the extremely low flow rates (e.g., less than 0.5 ml/hr) that can be necessary when administering an antidote. Another advantage is that use of an electrostatic drive and capacitive sensing (as represented inFIGS. 4 and 5 ) minimizes the power requirements of thesensor 58. Accordingly, the flow sensor taught by Tadigadapa et al. is ideal for achieving the high dosage accuracy, reliability, small size, biocompatibility, drug compatibility, and low power requirements needed for thedevice 50 of this invention. - The
reservoir 52 schematically depicted inFIG. 2 can be adapted to contain any number of antidotes or treatments for delivery to the individual. Furthermore, the amounts of these antidotes carried by thedevice 50 can be very small and concentrated, and therefore very potent, in view of the accuracy of theflow sensor 58.FIG. 3 depicts amanifold system 70 to which a number ofcartridges 72 are mounted to provide a multi-antidote infusion system that combines thereservoir 52,valve 54, andsensor 58 ofFIG. 2 in a single assembly. The manifold 70 comprises afluid manifold 74 and an electrical “manifold” orpower bus 76, to which eachcartridge 72 is fluidically and electrically connected throughconnectors manifold system 70 can be fabricated to carry asensor 58 andvalve 54 dedicated to eachcartridge 72. Since themanifold system 70 is modular, the sizes of thecartridges 72 can vary to accommodate different dosing requirements. Thepower bus 76 provides power to thesensors 58 andvalves 54, relays input and output signals between the controller 64 (not shown) and thesensors 58, and relays input signals from thecontroller 64 to thevalves 54. - While capable of being configured to have any number of
cartridges 72, themanifold system 70 depicted inFIG. 3 is notably equipped withsufficient cartridges 72 to treat the following eleven biochem agents that have antidotes and pose a serious threat in the hands of terrorists and rogue states: sarin, VX, tabun, soman, cyanide, lewisite (β-chlorovinyldichloroarsine), anthrax, brucellosis, bubonic plague, Q fever, and botulism. Themanifold system 70 is shown as being equipped with eightcartridges 72 that can contain atropine and 2-PAM-CI for nerve agents, botulism antitoxin, tetracycline and doxycycline for the initial treatment of anthrax, brucellosis, Q-fever and the plague, BAL or dimercaprol for lewisite and sodium nitrile followed by sodium thiosulphate for cyanide poisoning. Subsets of these drug combinations or alternate drugs could also be utilized in themanifold system 70. - Delivery of one or more antidotes can be initiated with the
controller 64 either through manual input by the user, a radio signal from a remote central location (e.g., thecontrol system 29 ofFIG. 1 ), or in response to one or more detecting devices (e.g., the detectingdevice 10 ofFIG. 1 ) carried on the person or placed in the local vicinity. The programmability of thedevice 50 can include, but is not limited to, which antidote or combinations of antidotes should be delivered, the dosage, and the timing of the delivery (e.g. continuous or intermittent) for a variety of treatment regimes. In addition, because antidote dose requirements for many chemical agents are body weight dependant, the programmability of thedevice 50 also preferably allows the user to preprogram his or her body weight into thedevice 50 to improve self-treatment and safety. - In addition to the above, the
device 50 can be configured to offer other advantages and functions. For example, the ability to measure antidote density can be used to prevent deliver of the wrong antidote or those that are spoiled or contain air bubbles or inclusions. Other functionalities that can be combined with thedevice 50 include indicating the location of the individual (e.g., through GPS (global positioning system)), broadcasting an alert signal to a remote center or others equipped withsimilar delivery devices 50 if delivery of an antidote is commenced in response to an attack, monitoring of the individual's biological functions (e.g., heart beat), sending such biological information to a remote center or another individual, etc. Along with the device 50 (including itsvalve 54, pump 56,sensor 58, and injection device), such additional components can be fabricated by micromachining to yield a fully integrated system that is small, low-power, rugged and biocompatible at high production volumes. - In use, after being notified of the presence of a biochem agent (such as by detection with the detecting device 10), the user can place a needle connected to the
device 50 in his or her body and then activate thedevice 50 to allow thedevice 50 to deliver the appropriate antidote combination and dosage based on the type and concentration of agent sensed. Alternatively, in high risk situations such as a battlefield or suspected contaminated area, a needle or catheter can be pre-inserted so that thedevice 50 can inject the appropriate antidote combination and dosage without any (or minimal) direct input or action from the user. In one particular example, a remote central detection system (e.g., making use of the detecting device 10) can be linked through a wireless radio network with one or more of thedelivery devices 50. When an alert from the central detection system is received, eachdevice 50 automatically selects the appropriate antidote(s) and delivers the antidote(s) at the appropriate dose and delivery timing to the individual wearing thedevice 50. In another example, eachdevice 50 has a keypad (not shown) to interface with thecontroller 64. When instructed that exposure to a chemical or biological agent has occurred (e.g., verbally, through a remote central detection system, with the detectingdevice 10, etc.), the user can punch in the appropriate code to cause thedevice 50 to select and deliver the correct antidote. In a third example, the detectingdevice 10 and thedelivery device 50 are contained in a single portable unit, so that the unit contains all of the components necessary to sense and automatically respond to a chemical or biological threat. - In view of the above, the present invention provides a
biochem detecting device 10 and anantidote delivery device 50 that can be combined into a single unit as a first defense for individuals against a chemical and/or biological attack. In combination, the detectingdevice 10 anddelivery device 50 provide for the automatic detection of the type and amount of biochem agent present, selection of an appropriate antidote combination from multiple reservoirs, preparation and mixing of the appropriate antidotes at the correct concentration, and delivery of such antidote(s) with great accuracy. As such, the invention provides a small, portable, rapid-response bio-protector that can be carried as standard equipment by a soldier or other at-risk personnel for rapid treatment during an attack without the intervention of a medical professional. If the treatment is carried out automatically, the invention has the further advantage of being capable of precise dose control and repeated, timed injections as may be necessary. - While the invention has been described in terms of certain embodiments, it is apparent that other forms could be adopted by one skilled in the art. Therefore, the scope of the invention is to be limited only by the following claims.
Claims (20)
1. A device capable of detecting a chemical or biological agent, the device comprising:
a freestanding tube portion comprising an internal passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion;
means for flowing a fluidic sample through the freestanding tube portion;
means for vibrating the freestanding tube portion at a resonant frequency thereof that varies with a combined density of the freestanding tube portion and contents of the internal passage;
means for sensing movement of the freestanding tube portion and producing an output signal based on the resonant frequency of the freestanding tube portion, the output signal being indicative of accumulation of the matter; and
means for identifying the agent in the fluidic sample based on the accumulation of the matter in the freestanding tube portion.
2. The device according to claim 1 , wherein the freestanding tube portion is a constituent of a unit sufficiently small and light-weight to be carried by a person.
3. The device according to claim 2 , wherein the unit comprises at least one antidote, means coupled to the at least one antidote for selecting the at least one antidote based on the agent identified by the identifying means, and means for delivering the at least one antidote into the body of the person.
4. The device according to claim 3 , wherein the delivering means comprises:
a second freestanding tube portion through which the at least one antidote flows;
means for vibrating the second freestanding tube portion at a resonant frequency thereof that varies with the density of the fluid flowing therethrough, the Coriolis effect causing the second freestanding tube portion to twist while being vibrated at resonance, the second freestanding tube portion exhibiting a degree of twist that varies with the mass flow rate of the fluid flowing therethrough;
means for sensing movement of the second freestanding tube portion and producing a first output signal based on the resonant frequency of second the freestanding tube portion and a second output signal based on the degree of twist of the second freestanding tube portion;
means for measuring elapsed time during which the fluid has flowed through the second freestanding tube portion; and
means for stopping flow of the fluid through the second freestanding tube portion in response to a specified amount of the at least one antidote having passed through the second freestanding tube portion based on the elapsed time and the second output signal.
5. The device according to claim 3 , wherein the unit comprises a plurality of antidotes and the selecting means selects among the plurality of antidotes.
6. The device according to claim 5 , wherein the selecting means is operable to select more than one antidote, and the delivering means is operable to deliver the more than one antidote into the body of the person.
7. The device according to claim 3 , wherein the delivering means operates to deliver the at least one antidote subdermally, intravenously, intra-arterially, subcutaneously, intramuscularly, intraperitoneally or intrathecally.
8. The device according to claim 1 , wherein the fluidic sample flowed by the flowing means through the freestanding tube portion is air, water, blood or urine.
9. The device according to claim 1 , wherein the freestanding tube portion, the vibrating means and the sensing means are contained within an evacuated, hermetically-sealed enclosure.
10. The device according to claim 1 , wherein the freestanding tube portion is a micromachine.
11. A method of detecting a chemical or biological agent, the method comprising the steps of:
flowing a fluidic sample through an internal passage within a freestanding tube portion, the passage containing a substance selective to a chemical or biological agent so that matter accumulates within the freestanding tube portion;
vibrating the freestanding tube portion at a resonant frequency thereof that varies with a combined density of the freestanding tube portion and contents of the internal passage;
sensing movement of the freestanding tube portion and producing an output signal based on the resonant frequency of the freestanding tube portion, the output signal being indicative of accumulation of the matter; and
identifying the agent in the fluidic sample based on the accumulation of the matter in the freestanding tube portion.
12. The method according to claim 11 , wherein the freestanding tube portion is a constituent of a unit carried by a person.
13. The method according to claim 12 , wherein the unit comprises at least one antidote, means coupled to the at least one antidote for selecting the at least one antidote, and means for delivering the at least one antidote into the body of the person, and wherein the method further comprises the steps of:
sending a signal to the selecting means based on the agent identified in the fluidic sample;
selecting with the selecting means the at least one antidote as being capable of counteracting the agent; and then delivering with the delivering means the at least one antidote into the body of the person.
14. The method according to claim 13 , wherein the step of delivering the at least one antidote comprises the steps of:
flowing the at least one antidote through a second freestanding tube portion;
vibrating the second freestanding tube portion at a resonant frequency thereof that varies with the density of the fluid flowing therethrough, the Coriolis effect causing the second freestanding tube portion to twist while being vibrated at resonance, the second freestanding tube portion exhibiting a degree of twist that varies with the mass flow rate of the fluid flowing therethrough;
sensing movement of the second freestanding tube portion and producing a first output signal based on the resonant frequency of second the freestanding tube portion and a second output signal based on the degree of twist of the second freestanding tube portion;
measuring elapsed time during which the fluid has flowed through the second freestanding tube portion; and
stopping flow of the fluid through the second freestanding tube portion in response to a specified amount of the at least one antidote having passed through the second freestanding tube portion based on the elapsed time and the second output signal.
15. The method according to claim 13 , wherein the unit comprises a plurality of antidotes and the selecting means selects among the plurality of antidotes.
16. The method according to claim 15 , wherein the selecting step comprises selecting more than one antidote, and the delivering step comprises delivering the more than one antidote into the body of the person.
17. The method according to claim 13 , wherein the at least one antidote is delivered subdermally, intravenously, intra-arterially, subcutaneously, intramuscularly, intraperitoneally or intrathecally.
18. The method according to claim 11 , wherein the fluidic sample is air, water, blood or urine.
19. The method according to claim 11 , wherein the freestanding tube portion is contained within an evacuated, hermetically-sealed enclosure, and the vibrating and sensing steps are performed by vibrating and sensing means contained within the enclosure.
20. The method according to claim 11 , further comprising the step of fabricating the freestanding tube portion using a micromachining process.
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US7354429B2 (en) | 2008-04-08 |
US20080065050A1 (en) | 2008-03-13 |
US20080152676A1 (en) | 2008-06-26 |
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