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Publication numberUS20120125527 A1
Publication typeApplication
Application numberUS 13/362,502
Publication date24 May 2012
Filing date31 Jan 2012
Priority date14 Aug 2003
Also published asCA2708998A1, EP2275149A2, EP2275149A3, US20100016891
Publication number13362502, 362502, US 2012/0125527 A1, US 2012/125527 A1, US 20120125527 A1, US 20120125527A1, US 2012125527 A1, US 2012125527A1, US-A1-20120125527, US-A1-2012125527, US2012/0125527A1, US2012/125527A1, US20120125527 A1, US20120125527A1, US2012125527 A1, US2012125527A1
InventorsJohn J. Kennedy, Joshua Stopek, Mark S. Roby
Original AssigneeTyco Healthcare Group Lp
Export CitationBiBTeX, EndNote, RefMan
External Links: USPTO, USPTO Assignment, Espacenet
Heterogeneous Yarns For Surgical Articles
US 20120125527 A1
Abstract
Heterogeneous yarns containing strands of dissimilar materials are useful in forming surgical device.
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Claims(18)
1. A method of manufacturing a yarn for use with a surgical device comprising:
positioning a plurality of heterogeneous strands in side-by-side fashion such that the plurality of heterogeneous strands are maintained in a parallel relation to one another;
applying a binding agent to the plurality of heterogeneous strands; and
setting the binding agent.
2. A method according to claim 1, further comprising forming the heterogeneous strands via an extrusion process.
3. A method according to claim 2, wherein the plurality of heterogeneous strands are extruded to a length from about 5 inches to about 144 inches.
4. A method according to claim 1, wherein positioning the plurality of heterogeneous strands occurs within a holding receptacle configured to maintain the plurality of heterogeneous strands in the parallel relation to one another.
5. A method according to claim 4, wherein the holding receptacle is a forming sheath.
6. A method according to claim 4, wherein the holding receptacle is a permanent sheath that is applied to a surface of the plurality of heterogeneous strands.
7. A method according to claim 4, wherein the holding receptacle is made from the same material as the plurality of heterogeneous strands.
8. A method according to claim 1, wherein setting the binding agent occurs by heating the binding agent.
9. A method according to claim 8, wherein heating the binding agent occurs at a temperature from about 70° C. to about 160° C.
10. A method according to claim 8, wherein heating the binding agent occurs at a temperature from about 100° C. to about 140° C.
11. A method according to claim 8, wherein heating the binding agent further comprises tensioning the plurality of heterogeneous strands to facilitate maintaining the parallel relation of the plurality of heterogeneous strands with respect to one another.
12. A method according to claim 1, wherein the binding agent is applied along the entire length of the plurality of heterogeneous strands.
13. A method according to claim 1, wherein the binding agent is applied along discrete locations along the length of the plurality of heterogeneous strands.
14. A method according to claim 1, wherein the binding agent is selected from the group consisting of biocompatible adhesives, thermoplastic resins, waxes, and combinations thereof.
15. A method according to claim 14, wherein the biocompatible adhesives are selected from the group consisting of synthetic absorbable and non-absorbable monomers and oligomers.
16. A method according to claim 15, wherein the synthetic absorbable and non-absorbable monomers and oligomers are selected from the group consisting of lactic acid, glycolic acid, caprolactone, dioxanone, polyethylene glycol (PEG), polypropylene glycol, isocyanates, copolymers thereof, and combinations thereof.
17. A method according to claim 1, wherein positioning the plurality of heterogeneous strands in side-by-side fashion forms a corresponding plurality of interstices between the plurality of heterogeneous strands.
18. A method according to claim 17, wherein the plurality of interstices are configured to provide an area for receiving the binding agent therein.
Description
    CROSS-REFERENCE TO RELATED APPLICATIONS
  • [0001]
    The present application is a divisional of, and claims the benefit of and priority to, co-pending U.S. patent application Ser. No. 12/504,954 filed on Jul. 17, 2009, which is a continuation-in-part of, and claims the benefit of and priority to, U.S. patent application Ser. No. 10/917,183 filed on Aug. 12, 2004, now abandoned, which claims priority to and the benefit of U.S. Provisional Application No. 60/494,993 filed on Aug. 14, 2003, the entire disclosures of each of which are hereby incorporated by reference in their entirety.
  • BACKGROUND
  • [0002]
    1. Technical Field
  • [0003]
    The present disclosure relates to yarns made of dissimilar materials. Filaments of at least two dissimilar materials are combined to form a yarn which, in turn, can be braided, woven, etc. to form a device suitable for surgical use.
  • [0004]
    2. Background of Related Art
  • [0005]
    Sutures intended for the repair of body tissues must meet certain requirements; they must be substantially non-toxic, capable of being readily sterilized, they must have good tensile strength and have acceptable knot-tying and knot-holding characteristics and, if the sutures are of the bio-absorbable variety, the bio-absorption of the suture must be closely controlled.
  • [0006]
    Sutures have been constructed from a wide variety of materials including surgical gut, silk, cotton, polyolefins such as polypropylene, polyamides, polyesters such as polyethylene terephthalate, polyglycolic acid, glycolide-lactide copolymer, etc. Sutures have been constructed from these materials in a monofilament form and as braided structures. For example, sutures manufactured from silk, polyamide, polyester and bio-absorbable glycolide-lactide copolymer are typically provided as multi-filament braids.
  • [0007]
    Filaments have also been utilized to form other mutli-filament surgical or medical devices, such as braided tapes, gauze, wound dressings, hernial repair meshes, vascular grafts (e.g. fabrics and/or tubes) anastomosis rings, prosthetic ligaments and tendons, growth matrices, drug delivery devices and other implantable medical devices. Multi-filaments braids typically provide the advantages of enhanced pliability, and tensile strength as compared to monofilament constructions, and where utilized as sutures, posses enhanced knot security. The enhanced pliability of a multi-filament braid is caused by a lower resistance to bending of a strand of very fine filaments as opposed to one large diameter monofilament. The individual filaments must be able to bend unencumbered or unrestricted by their neighboring filaments. Any mechanism which reduces this individual fiber mobility, such as simple fiber-fiber friction, a coating which penetrates into the braid interstices, or a melted polymer matrix which adheres fibers together, could adversely affect braid pliability. It would be advantageous to combine dissimilar materials or fibers to form filament strands to enhance pliability and strength.
  • SUMMARY
  • [0008]
    The present disclosure relates to biocompatible composite surgical devices made from heterogeneous yarns. The yarns contain multiple strands of a polyester material and multiple strands of a polyolefin material. The strands are combined in substantially parallel lengths with respect to each other to form the heterogeneous yarn. The yarns can then be braided, knitted or woven to form medical/surgical devices, including sutures.
  • BRIEF DESCRIPTION OF DRAWINGS
  • [0009]
    FIG. 1 is a cross sectional view of a heterogeneous yarn of polyester and polyolefin strands;
  • [0010]
    FIG. 2 shows a needle-suture combination in accordance with the present disclosure;
  • [0011]
    FIG. 3 is a perspective view of a portion of a split human sternum illustrating one application of the present invention for retaining the split portions together to promote healing;
  • [0012]
    FIG. 4 is an enlarged view of the suture product shown in FIG. 3 illustrating one embodiment wherein the elongated product is a flat braided member and contains at least eight reinforcing filaments extending along the length;
  • [0013]
    FIG. 5 is a view of an alternative embodiment of the suture repair product wherein the elongated member is a spiroid braided member having a generally circular cross-section containing at least one elongated reinforcing member; and
  • [0014]
    FIG. 6 is a view of another alternative embodiment of the suture repair product wherein the elongated product is a hollow braided member having a generally circular cross-section and contains at least one elongated reinforcing member extending centrally thereof along the length.
  • DETAILED DESCRIPTION
  • [0015]
    The present disclosure relates to heterogeneous yarns, which can be used in the fabrication in whole or in part of a variety of textile surgical devices, including, for example, sutures, braided tapes, gauze, wound dressings, hernial repair meshes, vascular grafts (e.g. fabrics and/or tubes) anastomosis rings, prosthetic ligaments and tendons, growth matrices, drug delivery devices and other implantable medical devices. An implantable medical device is defined as any device which can be implanted in an animal for medical purposes. The yarns can be braided, knitted or woven to form the devices.
  • [0016]
    In accordance with the present disclosure, at least two different kinds of fibers or strands are placed in intimate contact to form a heterogeneous yarn. More particularly, the heterogeneous yarns contain strands made from a polyester and strands made from a polyolefin. Multiple strands of polyester and polyolefin are combined to form a single yarn. Multiple heterogeneous yarns thus obtained are then braided, knitted, or woven to form a multi-filament surgical/medical device, such as, for example, a multi-filament surgical suture.
  • [0017]
    In particularly useful embodiments, the polyester strands are made of polyethylene terephthalate. Polyethylene terephthalate is a thermoplastic polyester formed by esterification from ethylene glycol and terephthalic acid. Its advantageous properties include high tensile strength, high resistance to stretching under both wet and dry conditions, and good resistance to degradation by chemical bleaches and to abrasion. Polyethylene terephthalate is commercially available from DuPont Corporation, Wilmington, Del., under the trademark DACRONŽ.
  • [0018]
    The polyolefin strands are preferably made from a polyethylene. In particularly useful embodiments, the polyethylene is an ultra high molecular weight polyethylene. Ultra high molecular weight (“UHMW”) polyethylene is a linear polymer with an average molecular weight greater than about 400,000, typically in the range of about 500,000 to about 6,000,000. UHMW polyethylene has a high tenacity and low elongation rate to provide articles with greatly increased strength and decreased elongation.
  • [0019]
    UHMW polyethylene typically exhibits a very substantial degree of crystalline orientation (95-99%) and crystalline content (60-85%). The significant strength and stability of UHMW polyethylene is normally caused by the high degree of molecular orientation. As a result, the fibers exhibit strengths from about 375 kpsi (thousands of pounds per square inch) to about 560 kpsi, and tensile moduli of about 15 msi (millions of pounds per square inch) to about 30 msi. Ultra high molecular weight polyethylene is commercially available under the trademark SPECTRAŽ. from Allied-Signal Technologies, Petersburg, Va., and under the trademark DYNEEMAŽ from DSM High Performance Fibers, JH Heerlen, The Netherlands.
  • [0020]
    The yarn may optionally contain strands of other materials. Materials used to construct these optional strands can include a wide variety of natural and synthetic fibrous materials such as any of those previously known for the construction of sutures. Such materials include non-absorbable as well as partially and fully bio-absorbable (i.e., resorbable) natural and synthetic fiber-forming polymers, including thermoplastics. Suitable non-absorbable materials can include, for example, polyamides, polyesters such as polyethylene terephthalate, polyacrylonitrile, polyolefins such as polyethylene and polypropylene, silk, cotton, linen, etc. Carbon fibers, steel fibers and other biologically acceptable inorganic fibrous materials can also be employed. Bio-absorbable resins can include those derived from glycolic acid, glycolide, lactic acid, lactide, dioxanone, epsilon-caprolactone, trimethylene carbonate, etc., and various combinations of these and related monomers.
  • [0021]
    The strands which form the yarns can be made using any known technique, such as, for example, extrusion, molding and/or solvent casting. In a preferred embodiment, the strands can be extruded through an extruder unit of a conventional type, such as those disclosed in U.S. Pat. Nos. 6,063,105; 6,203,564; and 6,235,869, the contents of each of which are incorporated by reference herein. The strands of dissimilar materials can be extruded separately and subsequently brought together into a group to form a yarn, or the strands can be extruded in a side-by-side fashion and collected together to immediately form a yarn. The number of strands used per yarn will depend on a number of factors including the desired final size of the yarn and the ultimate multi-filament article being produced. For example, with respect to sutures, size is established according to United States Pharmacopoceia (“USP”) standards. However, each yarn can contain at least ten strands, and often more, of at least two differing material types. The strands run parallel to each other along the length of the yarn. Although twisting the strands to form a twisted yarn is also contemplated.
  • [0022]
    Turning now to FIG. 1, heterogeneous yarn 10 of the present disclosure is shown. Yarn 10 may be formed, in embodiments extruded, to any suitable length. More particularly, the extruded length of the yarn 10 may be determined by the intent of use of the yarn 10. For example, in the instance where the intended use of the yarn 10 is for the manufacture of a suture 101, the yarn 10 includes a length that is at least equal to the length of the suture (see FIG, 2, for example). In embodiments, yarn 10 may include lengths that are from about 5 inches to about 144 inches. For illustrative purposes, a segment of a yarn 10 is depicted in FIG. 1 and includes a plurality of polyolefin strands 12 (such as, UHMW polyethylene) and polyester strands 14 (such as DACRONŽ). While only a segment of yarn 10 is depicted in FIG. 1, it is to be understood that, in embodiments, the parallel orientation of strands 12 and 14 may be maintained along the entire length of yarn 10 (not shown). In other words, the plurality of strands 12 and 14 run parallel to both each other and the longitudinal axis of yarn 10, along the length of yarn 10.
  • [0023]
    As noted above, yarn 10 may be formed by one or more known extrusion processes. After the strands 12 and 14 have been extruded and subsequently brought together and/or collected, each of the strands 12 and 14 are arranged and maintained so that they are in intimate contact with each other in a parallel relation relative to one another. This parallel configuration of strands 12 and 14 may increase the structural integrity of the yarn 10.
  • [0024]
    The strands 12 and 14 may be maintained in this parallel relation by any suitable methods and/or processes. For example, in an embodiment, the strands 12 and 14 may be temporarily positioned within a holding receptacle, such as, for example, a removable forming sheath (not shown). The forming sheath may be configured to maintain the strands 12 and 14 in a parallel configuration during the formation of the yarn 10.
  • [0025]
    In embodiments, after the strands 12 and 14 have been positioned within the forming sheath, the strands 12 and 14 may be subsequently bonded to each other by any means within the purview of those skilled in the art. Such means may include, for example, the application of heat, the use of binding agents, the use of coatings, combinations thereof, and the like. In embodiments, instead of a forming sheath, a permanent sheath may be applied to the external surface of yarn 10, thereby assisting in maintaining the parallel orientation of strands 12 and 14.
  • [0026]
    A sheath which is applied to the strands 12 and 14 and left thereon to maintain their parallel orientation may be formed of any materials used to form strands 12 and/or 14, as well as any other component utilized to form a suture of the present disclosure.
  • [0027]
    Depending upon the materials utilized to form the strands, in embodiments, suitable heating to fuse the strands together may include heating to from about 70° C. to about 160° C., in embodiments from about 100° C. to about 140° C.
  • [0028]
    The heating may be dependent upon the glass transition temperature of the materials utilized to form the strands. Moreover, in embodiments, it may be desirable to heat the strands under tension, to maintain the parallel orientation of the strands.
  • [0029]
    Suitable binding agents are within the purview of those skilled in the art and include suitable biocompatible adhesives, thermoplastic resins, waxes, combinations thereof, and the like. In embodiments, a plurality of interstices “I” may be formed between the plurality of strands 12 and 14. The interstices “I” run parallel to each other and the strands 12 and 14 along the length of the yarn 10. In embodiments, the plurality of interstices may be configured to provide an area for receiving the binding agent “A”. The binding agent “A” may be applied along the entire length of the yarn, or in discrete locations along the length of the yarn. In embodiments it may prove useful to apply the binding agent may be deposited at specific locations or nodes “n” along the length of the yarn, see FIG. 1. The plurality of nodes “n” and/or forming sheath may be configured to receive the binding agent at corresponding predetermined locations along the length of the yarn 10. The plurality of nodes “n” may be configured to maintain the strands 12 and 14 in a fixed parallel relation relative to one another.
  • [0030]
    Thus, in embodiments, a method for forming a yarn of the present disclosure may include positioning a plurality of strands in side-by-side fashion such that the plurality of strands are maintained in a parallel relation relative to one another, applying a binding agent to the plurality of heterogeneous strands, and setting the binding agent to assist in maintaining the strands in their parallel configuration.
  • [0031]
    Any biocompatible adhesive may be utilized. In embodiments, suitable adhesive materials include synthetic absorbable and non-absorbable monomers and oligomers including those synthesized from materials such as lactic acid, glycolic acid, caprolactone, dioxanone, polyethylene glycol (PEG), polypropylene glycol, isocyanates, copolymers thereof, combinations thereof, and the like. Adhesive materials may be combined with solvents for their application, including polar and non-polar solvents. Suitable solvents include alcohols, e.g., methanol, ethanol, propanol, chlorinated hydrocarbons (such as methylene chloride, chloroform, 1,2-dichloro-ethane), and aliphatic hydrocarbons such as hexane, heptene, ethyl acetate.
  • [0032]
    The specific manner in which the binding agent may be applied to the yarn 10 will depend on the contemplated uses of the suture. After the binding agent is applied to the strands 12 and 14, strands 12 and 14 and/or the binding agent may be set using known curing methods or processes (e.g., ultra-violet curing) or other suitable methods or processes not described herein.
  • [0033]
    In embodiments, the strands 12 and 14 and/or the binding agent may be simultaneously subjected to an ultra-violet curing process. Following the ultra-violet curing process, the forming sheath may be subsequently removed, producing a yarn 10 that includes the strands 12 and 14 in a fixed parallel configuration.
  • [0034]
    In embodiments, after the strands 12 and 14 have been set or formed in the fixed parallel configuration, the yarn 10 including the strands 12 and 14 may be treated with a suitable coating (not shown). In embodiments, the coating may be employed to facilitate in maintaining the strands 12 and 14 in a parallel configuration. Any biocompatible coating may be applied thereto, including those disclosed in U.S. Patent Application Publication Nos. 2008/0268243, 2007/0207189, 2007/0010856, 2006/0188545, 2004/0153125, and 2004/0147629, and U.S. Pat. Nos. 6,878,757, 6,136,018, 6,007,565, and 5,716,376, the entire disclosures of each of which are incorporated by reference herein.
  • [0035]
    A coating and/or sheath may be applied in discrete locations or, in embodiments, may be applied along the longitudinal distance of the suture. Where applied in discrete locations, the locations may be intermittent and/or discrete, or may be along one or more partial lengths of continuous and/or increasing and/or decreasing change in length along the suture.
  • [0036]
    Once formed, a plurality of the heterogeneous yarns 10 can then be braided, knitted, or woven together. The braiding can be done by any method known to those skilled in the art. For example, braid constructions for sutures and other medical devices are described in U.S. Pat. Nos. 5,019,093; 5,059,213; 5,133,738; 5,181,923; 5,226,912; 5,261,886; 5,306,289; 5,318,575; 5,370,031; 5,383,387; 5,662,682; 5,667,528; 6,203,564; the contents of each of which are incorporated by reference herein. Once the suture is constructed, it is preferably sterilized, by any means known to those skilled in the art.
  • [0037]
    Braided surgical devices made using heterogeneous yarns prepared in accordance with the disclosure can optionally be coated with one or more coating compositions to improve functional properties of the device. For example, a coating can be applied to improve surface lubricity and knot tie-down behavior. Suitable coating compositions include but are not limited to those disclosed in U.S. Pat. Nos. 3,867,190; 3,942,532; 4,047,533; 4,452,973; 4,624,256; 4,649,920; 4,716,203; 4,826,945; and 5,569,302, the disclosures of which are incorporated by reference herein. The coating can be applied using any known technique such as, for example coating, dipping, spraying or other appropriate techniques.
  • [0038]
    The amount of coating composition applied to the device will vary depending upon the specific construction of the device, its size and the exact material of its construction. In general, the coating composition will constitute from about 0.5 to about 4.0 percent by weight of the coated device or higher with a preferred range from about 1.0 percent to about 3.0 percent.
  • [0039]
    A surgical device prepared from the presently described heterogeneous yarns may also be impregnated with one or more medico-surgically useful substances, e.g., those which accelerate or beneficially modify the healing process when the suture is applied to a wound or surgical site. The medically useful or therapeutic agents can include varying amounts of one or more optional ingredients, such as, for example, bioactive substances such as biocidal agents, antibiotics, antimicrobials, medicants, growth factors, anti-clotting agents, analgesic, anesthetics, anti-inflammatory, etc., and the like. Medicants are defined as substances which are beneficial to the animal and tend to promote the healing process. For example, a braided suture can be provided with a therapeutic agent which will be deposited at the sutured site. The therapeutic agent can be chosen for its antimicrobial properties, capability for promoting wound repair and/or tissue growth, or for specific indications such as thrombosis. Antimicrobial agents such as broad spectrum antibiotics (gentamicin sulphate, erythromycin or derivatized glycopeptides) which are slowly released into the tissue can be applied in this manner to aid in combating clinical and sub-clinical infections in a surgical or trauma wound site. To promote wound repair and/or tissue growth, one or more biologically active materials known to achieve either or both of these objectives can also be applied to the braided suture. Such materials include any of several human Growth factors (HGFs), magainin, tissue or kidney plasminogen activator to cause thrombosis, superoxide dismutase to scavenge tissue-damaging free radicals, tumor necrosis factor for cancer therapy, colony stimulating factor, interferon, interleukin-2 or other lymphokines to enhance the immune system, and so forth.
  • [0040]
    The braided device prepared from heterogeneous yarns in accordance with this disclosure can also include, for example, biologically acceptable plasticizers, antioxidants, and colorants, which can be impregnated into the heterogeneous yarns of the device.
  • [0041]
    In addition, the yarn and/or product may be plasma treated depending upon the particular needs or intended application so as to reduce the perceived “slipperiness” of the product as desired.
  • [0042]
    The braided suture 101 prepared in accordance with this disclosure can have a needle 102 attached thereto as shown in FIG. 2, to provide a needle suture combination 100. In order to facilitate needle attachment, conventional tipping agents can be applied to the braid. Two tipped ends of the suture may be desirable for attaching a needle to each end of the suture to provide a so-called double armed suture. The needle attachment can be made by any conventional method such as crimping, swaging, etc., including those described in U.S. Pat. Nos. 5,133,738; 5,226,912; and 5,569,302, the disclosures of which are incorporated by reference herein.
  • [0043]
    As noted above the heterogeneous yarns of the present disclosure can also be utilized to form other surgical or medical articles, including, braided tapes, gauze, wound dressings, hernial repair meshes, vascular grafts (e.g. fabrics and/or tubes) anastomosis rings, prosthetic ligaments and tendons, growth matrices, drug delivery devices and other implantable medical devices.
  • [0044]
    Referring initially to FIG. 3 there is illustrated a sternum closure ribbon 110 constructed according to the present invention and positioned to retain portions 112, 114 of a human sternum 116 together. The band 110 is a braided product made from the heterogeneous yarns described herein. In FIG. 4, the band 110 shown in FIG. 3 is shown in greater detail as an elongated flat braided textile product prepared as described in U.S. Pat. No. 5,318,575, the disclosure of which is incorporated herein by reference, with the exception that heterogeneous yarns in accordance with the present disclosure are used in the construction.
  • [0045]
    Accordingly, it is possible in one application to position the reinforced structure 110 about the split portions 112, 114 of the human sternum 116 as shown in FIG. 3 whereby substantial force may be applied to the band by tying the band either by a knot 122 shown in FIG. 3, or by other techniques whereby significant force may be applied and retained to promote natural healing of the sternum portions 112, 114, e.g. mechanical connecting devices such as buckles, etc. See, for example, U.S. Pat. No. 4,813,416.
  • [0046]
    In FIG. 5, there is an alternative elongated embodiment of spiroid braided construction of generally circular cross-section and comprised of heterogeneous yarns 126 combined to form a braided rope-like construction of generally circular cross-sectional configuration. Braid constructions having a circular cross-section are described in U.S. Pat. Nos. 3,565,077 and 5,019,093. In FIG. 6 there is shown a hollow braid construction 128 having a sheath constructed of heterogeneous yarns 130 and having a core 132.
  • [0047]
    Surgical devices prepared from heterogeneous yarns in accordance with this disclosure can be packaged and sterilized in any conventional manner known to those skilled in the art.
  • [0048]
    It will be understood that various modifications may be made to the embodiments disclosed herein. For example, in any of the braided products described herein one or more of the yarns may be heterogeneous yarns in accordance with this disclosure while the remaining portions are made of absorbable or non-absorbable fibers or filaments. As one illustrative example, for braided products containing a core/sheath structure, the core may be a heterogeneous yarns in accordance with this disclosure while the sheath yarns can be made form other biocompatible fibers, including, but not necessarily, bioabsorbable fibers. Therefore the above description should not be construed as limiting, but merely as exemplications of preferred embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended hereto.
Patent Citations
Cited PatentFiling datePublication dateApplicantTitle
US4883486 *31 May 198828 Nov 1989Indu KapadiaProsthetic ligament
US5674286 *15 Jul 19927 Oct 1997United States Surgical CorporationBioabsorbable medical implants
Referenced by
Citing PatentFiling datePublication dateApplicantTitle
US8556966 *23 Mar 201115 Oct 2013Boston Scientific Scimed, Inc.Annuloplasty device
US20110238169 *23 Mar 201129 Sep 2011Boston Scientific Scimed, Inc.Annuloplasty device
WO2017019300A1 *13 Jul 20162 Feb 2017Drexel UniversityHeterogeneous filaments, methods of producing the same, scaffolds, methods of producing the same, droplets, and methods of producing the same
Classifications
U.S. Classification156/167, 156/180
International ClassificationD04H3/12, D04H3/08
Cooperative ClassificationA61L31/129, A61L17/105, D10B2331/04, C08L2203/12, D10B2321/02, A61L31/125, D02G3/448, C08L67/00, C08L23/06, D04C1/12, D10B2509/00, D10B2403/0311, D10B2509/04, D04C1/02
European ClassificationA61L31/12D, A61L17/10B, A61L31/12D10, D02G3/44H
Legal Events
DateCodeEventDescription
31 Jan 2012ASAssignment
Owner name: TYCO HEALTHCARE GROUP LP, CONNECTICUT
Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KENNEDY, JOHN J.;STOPEK, JOSHUA;ROBY, MARK;SIGNING DATESFROM 20090820 TO 20090924;REEL/FRAME:027625/0900
2 Oct 2012ASAssignment
Owner name: COVIDIEN LP, MASSACHUSETTS
Free format text: CHANGE OF NAME;ASSIGNOR:TYCO HEALTHCARE GROUP LP;REEL/FRAME:029065/0448
Effective date: 20120928