US20120022468A1 - Enteral Feeding Assembly - Google Patents
Enteral Feeding Assembly Download PDFInfo
- Publication number
- US20120022468A1 US20120022468A1 US13/189,023 US201113189023A US2012022468A1 US 20120022468 A1 US20120022468 A1 US 20120022468A1 US 201113189023 A US201113189023 A US 201113189023A US 2012022468 A1 US2012022468 A1 US 2012022468A1
- Authority
- US
- United States
- Prior art keywords
- tube
- enteral feeding
- feeding system
- tubing
- conduit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/1011—Locking means for securing connection; Additional tamper safeties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J15/00—Feeding-tubes for therapeutic purposes
- A61J15/0026—Parts, details or accessories for feeding-tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2048—Connecting means
- A61J1/2055—Connecting means having gripping means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2068—Venting means
- A61J1/2072—Venting means for internal venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J15/00—Feeding-tubes for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1027—Quick-acting type connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1033—Swivel nut connectors, e.g. threaded connectors, bayonet-connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1094—Tube connectors; Tube couplings at least partly incompatible with standard connectors, e.g. to prevent fatal mistakes in connection
Abstract
An enteral feeding system for use with a syringe or extension tubing, such as an enteral feeding syringe or tubing, is provided. The system has features to balance the pressure within the tubing.
Description
- This application is a non-provisional of U.S. Provisional Patent Application Ser. No. 61/367,228 filed Jul. 23, 2010, entitled “Enteral Feeding Connector and Assembly”, the contents of which are fully incorporated herein by reference.
- The present invention relates generally to tubing connectors and tubing, and more particularly in one aspect to an enteral feeding assembly including an improved tubing designed to deal with undesired vacuum as well as overpressure issues.
- Fluid delivery systems, such as feeding tubes, are used to deliver nutrients and medicine to patients. The state of being fed by a feeding tube is known in the art as enteral feeding or tube feeding.
- As an example, in a neo-natal unit, infants are often fed enterally. A tube is inserted in is the mouth or nasal opening of the infant and down through the esophagus for delivery of the fluid to the stomach or intestinal region of the body. In this example, breast milk or formula are delivered by syringe into an enteral delivery system, such as an enteral tube, for delivery into the infant's stomach. However, enteral feeding systems can also be for pediatric or adult use. Sometimes a peristaltic pump is used to deliver fluids from a feeding bag.
- In the course of using the feeding tube, it is possible that an overpressure can develop in the tube and/or the infant's stomach. Alternatively, an excessive vacuum state can exist during aspiration, where the tubing is generating an undesired suction force at the openings in its distal tip.
- An improved enteral feeding system is provided. The system comprises a tube having a first end, a second end, an exterior sidewall, a conduit within said tube between said first end and a location near said second end, a first orifice, and a second orifice. The second orifice is located downstream of the first orifice, extending from a point below an end of the conduit to a point along the length of the conduit. This helps to alleviate certain undesired suction issues, as well as inhibit bacterial collection and growth. To prevent excessive negative pressure within the tubing, as at an orifice, the tubing may comprise a collapsible feature formed therein. The collapsible feature may comprise a thinned region that collapses when excessive negative pressure is applied, effectively cutting off further negative pressure from being exerted and giving the clinician an indication that an excessive vacuum is being applied.
- A supporting structure may additionally be present on the tubing, in the form of a cage is structure. The tubing may comprise a thinned region in the area surrounded by the cage structure that balloons out if excessive pressure is applied within the tubing.
- A one-way valve may be removably attachable to a tube section, either at an end of the tube section, or along the length of the tube section. Where the one-way valve is attached to the end of the tube section, either a cap or a syringe may be pushed into the valve to send air to a channel within the valve, which then flows through the tubing. In some embodiments, one-way valves may be placed along the length of the tube section to release pressure from within a conduit in the tubing.
- In another embodiment, an enteral feeding system is provided that comprises a first tube section comprising a first end, a second end, an exterior sidewall, and a conduit within the first tube section that extends from the first end to the second end. The first tube section is removably attachable to a tubing.
- These and other aspects, objects, and accomplishments of the present invention will be further understood upon consideration of the following detailed description of certain embodiments, taken in conjunction with the below drawings depicting various embodiments, in which:
- Various exemplary embodiments are described herein with reference to the following drawings, wherein like numerals denote like parts.
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FIG. 1 is a perspective view of an enteral feeding system; -
FIG. 2 is an enteral feed tube with novel modifications to deal with suction issues at the distal tip; -
FIG. 3 shows a modified proximal end-structure to the tubing ofFIG. 2 ; -
FIG. 4 is an enteral feed tube section like that ofFIG. 2 , modified to be retrofit to standard tubing; -
FIG. 5 is an enlarged, partial view of an enteral feed tube with a pressure release valve; -
FIG. 6 is an enlarged, partial view of an enteral feed tube with a pressure release valve; -
FIG. 7A is a partial view of an enteral feed tube section with a one-way valve; -
FIG. 7B is a top view of the one-way valve ofFIG. 7A ; and -
FIG. 8 is an enteral feed tube with novel modifications to deal with excessive pressure issues within the tube. - The connector and assembly of the present invention will be described herein for use with an enteral feeding tube, but it is contemplated that the connector assembly of the present invention can be used in any device that may benefit from this type of assembly.
-
FIG. 1 is a perspective view of a typicalenteral feeding system 100, in accordance with exemplary embodiments.Enteral feeding system 100 has asyringe 110 and atube 120. Syringe 110 has adistal end 112, aproximal end 114, and aplunger 118. Atproximal end 114 is asyringe tip 116. Tubing 120 has afirst end 122 and asecond end 124. In thissystem 100,first end 122 oftube 120 andsyringe tip 116 may be removably secured together. To securesyringe tip 116 tofirst end 122 oftube 120,syringe tip 116 is manually inserted intofirst end 122 oftube 120. -
FIG. 2 shows an enteral feed tube with novel modifications. Tube 800 is similar in form to a standard enteral feed tube, but with several new features. One is in thetube end 802, which is inserted into the patient. It has been the case in standard enteral tubing that an orifice is 804 (sometimes referred to as a drainage eye), is located upstream from thesolid tube end 802. This leaves a volume below the eye in the tube end which can retain fluid therein. To eliminate this undesirable fluid eddy in the tube end, in which bacteria growth may occur for instance, anotherorifice 806 is formed intube end 802. This orifice extends in this embodiment from a point below whereinterior channel 808 of the tubing ends (shown at 808′), to a point thereabove. Thus, any fluid in the very tip of the tube end interior will have an outlet to drain, so as to eliminate the foregoing fluid eddy or trap. - In certain instances, it may be desirable to apply a suction force to the
tube 800. In order to alleviate the possibility that soft tissue might be unintentionally pulled upon and thereby traumatized by an excessive negative pressure, as atorifice 804,tube 800 has a collapsible feature formed therein at 812. In this embodiment,collapsible feature 812 has athinned region 814 formed in the tubing sidewall.Thinned region 814 is designed to collapse the interior of the tubing in this area, such thatthinned sidewall 814′ will substantially come together along the axis of the tubing, serving to cut off further application of vacuum (negative pressure) attube end 802. - A supporting structure is provided around thinned
region 814 to otherwise maintain the tubing open in normal use, except in the circumstance when an undesirable vacuum is generated. Here, this supporting structure takes the form of a surrounding blister, formed surrounding the tubing sidewall. Of course, the supporting structure could be struts, webbing, or the like which serves to maintain the parts of the tubing upstream and downstream of the thinnedregion 814 apart, andtubing channel 808 open in normal use.FIG. 3 , for example, shows aflexible cage structure 820 which has been added to the tubing (as by press fit, fusing, gluing, ultrasonic welding, etc.).Cage structure 820 has anupper ring 821 and alower ring 822 withribs 824 extending therebetween.Cage structure 820 maintains the integrity of tubing is and thechannel 808 open, except in the presence of an undesirable vacuum being applied. - Returning to
FIG. 2 , acap 825 is provided to close theupstream end 801 of thetubing 800.Upstream end 801 is shown here as adapted to receive the tip of a feeding syringe for instance, or some other tip or end effector from a device to be connected to the tubing.Cap 825 is tethered to thetube 800 viatether 826.Cap 825 is useful not only in keeping the tube closed until connection, but also in use, as when changing an item that is connected to the tubing. - In this same regard, the embodiment of
FIG. 3 also has a tethered cap, but slightly modified. Note particularly in this embodiment that the upstream end of the enteral feeding tubing has been adapted to have a connector structure, formed integral therewith, at least as to the syringe/container connecting portion. As will be therefore seen, theexterior surface 210 in this area has the one or more flanges/protuberances 220 formed thereon. - This
cap 828 has a “no-touch” feature in the form of aplug 829 formed thereon, which will fit in and closeinterior conduit 216, with thecap closing aperture 215. A user handling thecap 828 thus need not contact theplug 829, reducing the risk of contaminating theconduit 216. Other no-touch features may be present on various connectors that may be used with the feeding system, such as those described in U.S. Provisional Patent Application Ser. No. 61/367,228, which is herein incorporated by reference. -
FIG. 4 shows an alternative embodiment of an enteral feed tube, such as the enteral feed tube ofFIG. 2 . As shown inFIG. 4 , feedtube 800 is the same as that shown inFIG. 2 , but is designed to be inserted, or retrofit, to standard tubing, such as tubingfirst end 122 shown inFIG. 1 . TheFIG. 4 embodiment thus has ashort tube part 803 that terminates in atip 807 having anopening 805.Tip 807 is sized to fit into the standard tubing proximal end in an interference is fit, luer lock, screw fit, or the like. -
FIG. 5 is an enlarged, partial view of an enteral feed tube with avacuum release valve 830. Thevacuum release valve 830 shown inFIG. 5 is a spring-loaded valve, and may be present on thefirst tube section 803 to provide for vacuum release in addition to or in place of eithercage structure 820 orcollapsible feature 812.Vacuum release valve 830 comprises ahousing 832 that extends fromtubing 800. At one end ofhousing 832 is anopening 834. Aspring 836 resides withinhousing 832, and serves to press a closure overopening 834 and opens when the vacuum withintubing 800 is sufficiently high.Vacuum release valve 830 may be a one-way valve, allowing for air to flow throughtubing 800, and to enterhousing 832 viaopening 834. -
FIG. 6 is an enlarged, partial view of an enteral feed tube with apressure release valve 840. Thepressure release valve 840 shown inFIG. 6 is an umbrella valve, and may be present on thefirst tube section 803 to provide for pressure release in addition to or in place of eitherflexible cage structure 820 orcollapsible feature 812.Pressure release valve 840 comprises astem 842 and ahead 844.Stem 842 is placed through a hole intubing 800.Pressure release valve 840 may be a one-way valve, allowing for fluid to flow throughtubing 800, and to exithousing 832 viaopening 834. -
FIG. 7A is a partial view of an enteral feeding tube section with a one-way valve 910 and atethered cap 925. One-way valve 910 may be removably attachable totube section 122 as shown inFIG. 7A . Thus, when eithercap 925 or a syringe is pushed intovalve 910, a flexible element 914 is collapsed upon itself, opening a channel into the top of thevalve 910.Cap 925 may comprise an orifice or other means to allow air into the valve. Fluid, such as is enteral feed, may then flow intovalve 910 and intotubing 122, or air may be allowed to exit for venting.Valve 910 has the flexible elongate member 914 in achamber 916. Flexible member 914 has scallopedareas 917, and is fixed atdistal end 918, but free to move longitudinally atproximal end 919.Proximal end 919 is located within atop disk 921 of the valve structure (shown inFIG. 7B ), and closes an orifice therein. When pressed by a syringe-tip, for example, proximal end moves distally, opening the orifice. When the syringe is removed, flexible member 914 returns to its rest position, closing the orifice.Valve 910 may be a syringe valve such as those manufactured by Halkey Roberts, such as the 245 SERIES Swabable Valve. -
FIG. 8 is an enteral feed tube with novel modifications to deal with other issues, as at the distal tip. The enteral feed tube isFIG. 8 is similar to that ofFIG. 3 , and has the additional feature of thinnedregion 814, but here being designed to expand, or “balloon out” if excessive pressure is exerted in thetubing 800. Thus, a user can determine simply by viewing the thinnedregion 814 whether too much pressure is present withintubing 800, or within the infant's stomach. Thinnedregion 814 may touchcage 824 when in the extended position. Thinnedregion 814 may also be designed to collapse the interior of the tubing in this area if excessive vacuum pressure is applied as well, as described with reference toFIG. 3 . - Various exemplary embodiments and methods have been described above. Those skilled in the art will understand, however, that changes and modifications may be made to those examples without departing from the scope and spirit of the present invention. Additional and/or different features may be present in some embodiments of the present invention.
Claims (20)
1. An enteral feeding system comprising:
a tube having a first end, a second end, an exterior sidewall, a conduit within said tube between said first end and a location near said second end;
a first orifice; and
a second orifice located downstream of said first orifice, wherein said second orifice extends from a point below an end of said conduit to a point along the length of said conduit.
2. The enteral feeding system of claim 1 , said tube further comprising a collapsible feature formed on said tube, said collapsible feature collapsing at least a portion of said conduit within said tube when a vacuum is applied.
3. The enteral feeding system of claim 2 , said collapsible feature comprising a thinned region formed in said tube exterior sidewall.
4. The enteral feeding system of claim 3 , said collapsible feature further comprising a is supporting structure that extends around said thinned region.
5. The enteral feeding system of claim 4 , wherein said supporting structure further comprises a plurality of arms extending from said exterior sidewall of said tubing, wherein said arms span at least the length of said thinned region.
6. The enteral feeding system of claim 4 , wherein said supporting structure further comprises a plurality of webs extending from said exterior sidewall of said tubing, wherein said webs spans at least the length of said thinned region.
7. The enteral feeding system of claim 4 , wherein said supporting structure further comprises a cage structure extending from said exterior sidewall of said tubing, wherein said cage spans at least the length of said thinned region.
8. The enteral feeding system of claim 5 , wherein when a vacuum pressure applied within said conduit is larger than a pre-designated vacuum pressure, said thinned region expands outward toward said plurality of arms.
9. The enteral feeding system of claim 1 , said tube further comprising a cap attached to said tube at said first end with a tether.
10. The enteral feeding system of claim 9 , wherein said cap comprises a plug within the interior surface of said cap, said plug being sized and shaped to fit within and close said conduit.
11. An enteral feeding system comprising:
a first tube section comprising a first end, a second end, an exterior sidewall, and a conduit within said first tube section and extending from said first end to said second end, said conduit designed to collapse upon itself and close said conduit under vacuum within said tube which exceeds a designated threshold;
wherein said first tube section is removably attachable to a tubing.
12. The enteral feeding system of claim 11 , wherein when said first tube section is attached to said tubing, said first tube section conduit is in fluid communication with a conduit within said tubing.
13. The enteral feeding system of claim 11 , said tube further comprising a collapsible feature formed on said tube, said collapsible feature collapsing at least a portion of said conduit within said tube when a vacuum is applied.
14. The enteral feeding system of claim 13 , said collapsible feature further comprising a thinned region formed in an exterior sidewall of said tube.
15. A enteral feeding system of claim 14 , said collapsible feature further comprising a supporting structure that extends around said thinned region.
16. The enteral feeding system of claim 15 , wherein said supporting structure further comprises a plurality of arms extending from said exterior sidewall of said tubing, wherein said plurality of arms spans at least the length of said thinned region.
17. The enteral feeding system of claim 15 , wherein said supporting structure further comprises a plurality of webs extending from the exterior sidewall of said tubing, wherein said webs spans at least the length of said thinned region.
18. The enteral feeding system of claim 15 , wherein said supporting structure further comprises a cage structure extending from said exterior sidewall of said tubing, wherein said cage spans at least the length of said thinned region.
19. The enteral feeding system of claim 11 , said tubing further comprising a one-way is valve.
20. The enteral feeding system of claim 19 , said tube further comprising a cap attached to said tube at said first end with a tether.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US13/189,023 US20120022468A1 (en) | 2010-07-23 | 2011-07-22 | Enteral Feeding Assembly |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US36722810P | 2010-07-23 | 2010-07-23 | |
US13/189,023 US20120022468A1 (en) | 2010-07-23 | 2011-07-22 | Enteral Feeding Assembly |
Publications (1)
Publication Number | Publication Date |
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US20120022468A1 true US20120022468A1 (en) | 2012-01-26 |
Family
ID=45494190
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/189,023 Abandoned US20120022468A1 (en) | 2010-07-23 | 2011-07-22 | Enteral Feeding Assembly |
US13/189,031 Expired - Fee Related US10004889B2 (en) | 2010-07-23 | 2011-07-22 | Enteral feeding connector and assembly |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US13/189,031 Expired - Fee Related US10004889B2 (en) | 2010-07-23 | 2011-07-22 | Enteral feeding connector and assembly |
Country Status (4)
Country | Link |
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US (2) | US20120022468A1 (en) |
EP (2) | EP2598200A4 (en) |
CN (2) | CN103140257A (en) |
WO (2) | WO2012012733A1 (en) |
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CN115919657A (en) * | 2023-03-15 | 2023-04-07 | 潍坊市人民医院(潍坊市公共卫生临床中心) | Nutrition tube is fed to intestines and stomach postoperative disease |
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USD925731S1 (en) | 2019-06-20 | 2021-07-20 | Becton, Dickinson And Company | Enteral syringe |
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CN115919657A (en) * | 2023-03-15 | 2023-04-07 | 潍坊市人民医院(潍坊市公共卫生临床中心) | Nutrition tube is fed to intestines and stomach postoperative disease |
Also Published As
Publication number | Publication date |
---|---|
US10004889B2 (en) | 2018-06-26 |
EP2598200A4 (en) | 2016-07-27 |
CN103124581A (en) | 2013-05-29 |
EP2595688A4 (en) | 2014-07-23 |
WO2012012728A1 (en) | 2012-01-26 |
WO2012012733A1 (en) | 2012-01-26 |
WO2012012728A9 (en) | 2012-03-22 |
CN103140257A (en) | 2013-06-05 |
EP2598200A1 (en) | 2013-06-05 |
EP2595688A1 (en) | 2013-05-29 |
US20120022457A1 (en) | 2012-01-26 |
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