US20100096311A1 - Blood treatment dialyzer/filter design to trap entrained air in a fluid circuit - Google Patents

Blood treatment dialyzer/filter design to trap entrained air in a fluid circuit Download PDF

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Publication number
US20100096311A1
US20100096311A1 US11/577,126 US57712605A US2010096311A1 US 20100096311 A1 US20100096311 A1 US 20100096311A1 US 57712605 A US57712605 A US 57712605A US 2010096311 A1 US2010096311 A1 US 2010096311A1
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United States
Prior art keywords
blood
processing element
outlet
air
header
Prior art date
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Abandoned
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US11/577,126
Inventor
James M. Brugger
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NxStage Medical Inc
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NxStage Medical Inc
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Priority to US11/577,126 priority Critical patent/US20100096311A1/en
Assigned to NXSTAGE MEDICAL, INC. reassignment NXSTAGE MEDICAL, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: BRUGGER, JAMES M.
Assigned to GE BUSINESS FINANCIAL SERVICES INC. reassignment GE BUSINESS FINANCIAL SERVICES INC. SECURITY AGREEMENT Assignors: EIR MEDICAL, INC., MEDISYSTEMS CORPORATION, MEDISYSTEMS SERVICES CORPORATION, NXSTAGE MEDICAL, INC.
Assigned to EIR MEDICAL, INC., MEDISYSTEMS CORPORATION, MEDISYSTEMS SERVICES CORPORATION, NXSTAGE MEDICAL, INC. reassignment EIR MEDICAL, INC. RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: GE BUSINESS FINANCIAL SERVICES INC.
Assigned to ASAHI KASEI KURARAY MEDICAL CO., LTD. reassignment ASAHI KASEI KURARAY MEDICAL CO., LTD. INTELLECTUAL PROPERTY SECURITY AGREEMENT Assignors: EIR MEDICAL, INC., MEDISYSTEMS CORPORATION, MEDISYSTEMS SERVICES CORPORATION, NXSTAGE MEDICAL, INC.
Assigned to SILICON VALLEY BANK reassignment SILICON VALLEY BANK SECURITY AGREEMENT Assignors: NXSTAGE MEDICAL, INC.
Publication of US20100096311A1 publication Critical patent/US20100096311A1/en
Assigned to NXSTAGE MEDICAL, INC. reassignment NXSTAGE MEDICAL, INC. RELEASE OF SECURITY INTEREST Assignors: SILICON VALLEY BANK
Assigned to MEDISYSTEMS CORPORATION, MEDISYSTEMS SERVICES CORPORATION, NXSTAGE MEDICAL, INC. reassignment MEDISYSTEMS CORPORATION RELEASE BY SECURED PARTY (SEE DOCUMENT FOR DETAILS). Assignors: ASAHI KASEI MEDICAL CO., LTD. F/K/A ASAHI KASEI KURARAY MEDICAL CO., LTD.
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621—Extra-corporeal blood circuits
    • A61M1/3627—Degassing devices; Buffer reservoirs; Drip chambers; Blood filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0021—Degasification of liquids by bringing the liquid in a thin layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0042—Degasification of liquids modifying the liquid flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/20—Accessories; Auxiliary operations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/24—Dialysis ; Membrane extraction
    • B01D61/30—Accessories; Auxiliary operation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D65/00—Accessories or auxiliary operations, in general, for separation processes or apparatus using semi-permeable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/15—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with a cassette forming partially or totally the flow circuit for the treating fluid, e.g. the dialysate fluid circuit or the treating gas circuit
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/06—External membrane module supporting or fixing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/18—Specific valves

Definitions

  • FIG. 5 illustrates a header cap with a hydrophobic membrane for automatically venting air.
  • the entire assembly that includes the filter 100 , tubing 265 , and microporous filter end cap 253 may be fused, sealed, and sterilized as a unit.
  • the same may be fused, sealed and sterilized as a unit with an entire treatment circuit, combining it with the circuit described in U.S. patent application Ser. No. 10/650,935 published as US 2004-0069709, which is hereby incorporated by reference as if full set forth in its entirety herein. With this combination, the entire circuit may be isolated from contamination.

Abstract

A modification in the configuration of the blood microtubular filter/dializer used in many kinds of renal replacement therapy systems can provide highly a effective mechanism for removing air from the blood circuit of such systems. In embodiments, for example, the invention takes advantage of the slow flow rate that usually occurs where blood exits the microtubules into a header area of the filter to provide a settling area and, preferably, a air relief mechanism.

Description

    BACKGROUND
  • One of the problems with fluid circuits in blood treatment systems is entrained air (bubbles) in treatment fluids, infusate, or blood. Treatment systems normally have air detectors to prevent air from being injected into a patient, either because a venous line carrying blood back to the patient contains air or because an infusate line, such as the replacement fluid line of a hemofiltration system, contains air. It is desirable for the air detectors to be made sufficiently sensitive to prevent the rare instances of long trains of air bubbles being injected into a patient. But sensitivity high enough to prevent long thin trains of bubbles may be high enough to alarm very small amounts of air which pose no risk. In other words, sensitive air detectors alarm on a lot of fall positives if they protect against all possible risks.
  • To eliminate false positives, a prior art approach has been to remove as much air from a protected fluid circuit as possible. Putting air traps in fluid circuits, particularly blood lines, has drawbacks. Air-settling chambers necessarily involve stagnant flow, which creates a risk of forming clots (e.g., for blood) or sedimentation or other concentration of entrained material (e.g. medication).
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a cross-section view of a filter usable in a variety of different types of blood treatment systems oriented to trap air in one or two header portions of the filter.
  • FIG. 2 illustrates a holder of a blood treatment machine to orient the filter of FIG. 1.
  • FIG. 3 illustrates a filter similar to that of FIG. 1 but with a header port for removing air and/or disrupting or cleaning clots.
  • FIG. 4 illustrates an assembly for use with the port of FIG. 3 for removing air and/or disrupting or cleaning clots.
  • FIG. 5 illustrates a header cap with a hydrophobic membrane for automatically venting air.
    •  DETAILED DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a cross-section view of a filter usable in a variety of different types of blood treatment systems oriented to trap air in one or two header portions of the filter. A filter 100, which may be a dialyzer, hemofilter, hemodiafilter, or any other compatible blood treatment has a bundle of tubular media 132 connecting an arterial 160 and venous 155 head space which is isolated from a filtrate space 130. Blood flows through ports 122 and 124 in header caps 110 and 136 as indicated by arrows 118 and 112 into and out of the arterial 160 and venous 155 head spaces, respectively. A cylindrical filter body 128 encloses the filtrate space 130 and contains filtrate (e.g., dialyzer) ports 126 and 120. Arterial and venous headers 142 and 134 isolate the filtrate space 130 from the respective arterial 160 and venous 155 head spaces.
  • The orientation of the filter 100 with respect to the pull of gravity is shown with the understanding that gravity is assumed to pull down with respect to the profile orientation of the drawing page. If any air is entrained in the blood, it may settle in pockets 151 and 153 in the arterial 160 and venous 155 head spaces as indicated by air/ liquid interfaces 152 and 150. The flow of blood through the arterial 160 and venous 155 head spaces is extremely slow due to the very small cross-sectional areas of the filter fibers in the bundle 132. As a result, the arterial 160 and venous 155 head spaces are an idea place for air to settle out. With the indicated orientation, with blood outlet 124 pointing down and away from the pocket 151. Since the blood moves at a very slow rate in the arterial 160 and venous 155 head spaces, there is little risk of reentrainment and air settles out very effectively.
  • Air trapped in pocket 153 may travel through filter fibers in bundle 132 up to venous head space 155 and accumulate in pocket 151. Since the pocket 153 is located near the top of the arterial head space 160, air will tend to travel up a few of the fibers closest to the top and collect in the pocket 151 without mixing in with blood. This keeps the vast majority of fibers filled with blood.
  • FIG. 2 illustrates a holder 175 of a blood treatment machine to orient the filter of FIG. 1. The holder 175 may be attached at a base thereof (not shown separately) to a blood treatment machine 172 which may contain actuators, sensors, and control elements as well as a fluid circuit, here illustrated as a cartridge 180 enclosed between two parts 171 and 172 of the blood treatment machine 172. A filter 100 that is preconnected to the fluid circuit can easily be mounted in such an apparatus. The holder 175 may be articulating to allow for some movement or change of orientation of the filter 100 and is preferably a spring tensioned clamp that allows for one-handed insertion of a filter 100. In an alternative embodiment, the holder 175 may be attached to the 180 cartridge such that its orientation is obtained when the cartridge 180 is positioned with respect to the blood treatment machine 170.
  • FIG. 3 illustrates a filter similar to that of FIG. 1 but with a header cap 210 having an integrated header port 200 for removing air and/or disrupting or cleaning clots. Tubing 265 may be connected to the port and provided with a clamp 260. The clamp 260 may be released, at intervals, by an operator, to vent air from the air pocket 251 and re-engaged to prevent blood loss. The clamp 260 may be a normally-closed type clamp with a strong spring so that it reclamps tubing 265 when released. The tubing 265 may be capped with a microporous filter end cap 253 to prevent any contamination re-entering the blood in the venous head space 155. The entire assembly that includes the filter 100, tubing 265, and microporous filter end cap 253 may be fused, sealed, and sterilized as a unit. In addition the same may be fused, sealed and sterilized as a unit with an entire treatment circuit, combining it with the circuit described in U.S. patent application Ser. No. 10/650,935 published as US 2004-0069709, which is hereby incorporated by reference as if full set forth in its entirety herein. With this combination, the entire circuit may be isolated from contamination.
  • FIG. 4 illustrates an assembly 350 for use with the port of FIG. 3 for removing air and/or disrupting or cleaning clots. The port 200 has a tube 310 connecting the venous head space 155 with a stopcock 312. The stopcock 312 is further connected to a syringe 320 and tubing 375 connecting a supply of blood normal saline 375 and 360. The stopcock allows the syringe to be connected, in a first position, to draw saline from the source of saline 375 and, in a second position, air from the venous head space 155. In the second position, saline may be pushed into the head space 155 to clear clots or for prophylaxis by injecting heparin. In an illustrative usage method, the stopcock 312 is set in the second position and air is drawn from the head space 155. Then it is set in the first position and saline is drawn into the syringe 320. Then the stopcock 312 is set in the second position again and saline (or saline and heparin) is injected into the venous head space 155. The apparatus including the stopcock 312, syringe 320, tubing 310, 375, 360 and clamp 260 may be pre-attached to the filter 100 and presterilized as a unit.
  • FIG. 5 illustrates a header cap 210 with cover 280 sealed to and covering the header port 200. The cover includes a hydrophobic membrane 285 that allows air in the head space 155 to vent automatically while preventing any contamination from entering.

Claims (26)

1. A blood treatment apparatus, comprising:
a blood processing element including filter media through which blood passes;
said processing element having a header chamber at a position where blood exits a portion of said blood processing element, said header chamber having at least one outlet;
a holder configured to support said processing element in a position and orientation such that air can accumulate in said header chamber in a position remote from said outlet whereby said header chamber is enabled to remove air from blood.
2. Apparatus as in claim 1, wherein said processing element is attached to a fluid circuit and forms a part of a disposable set.
3. Apparatus as in claim 1, wherein said holder is fixedly attachable to a blood treatment machine.
4. Apparatus as in claim 1, wherein said holder is configured to support said filter at an angle with respect to the vertical, as defined with respect to the force of gravity.
5. Apparatus as in claim 1, wherein said processing element includes tubular membrane media that are vertically oriented in ordinary use.
6. A blood treatment apparatus, comprising:
a blood dialyzer or hemofilter processing element including filter media through which blood passes;
said processing element having a header chamber at a position where blood exits a treatment portion of said blood processing element, said header chamber having at least one blood outlet and at least one auxiliary outlet;
a holder configured to support said dialyzer or hemofilter in a position and orientation such that air can accumulate in said header chamber in a position in said header space that is adjacent and in communication with said auxiliary outlet.
7. Apparatus as in claim 6, wherein said auxiliary outlet is remote from said blood outlet.
8. Apparatus as in claim 6, wherein said auxiliary outlet is opposite said blood outlet.
9. Apparatus as in claim 6, further comprising a valve connected to said auxiliary port and pre-connected and sterilized together with said blood processing element.
10. Apparatus as in claim 6, further comprising a stopcock connected to said auxiliary port and pre-connected and sterilized together with said blood processing element.
11. Apparatus as in claim 6, further comprising a syringe connected to said auxiliary port and pre-connected and sterilized together with said blood processing element.
12. Apparatus as in claim 6, further comprising a holder configured to orient said blood processing element such that said at least one blood outlet is lower, with respect to a direction of gravity, than said auxiliary outlet.
13. Apparatus as in claim 6, further comprising an gas release component connected to said auxiliary port and pre-connected and sterilized together with said blood processing element, said air release component being configured to permit gas to egress from said header space without permitting blood to egress from said header space.
14. Apparatus as in claim 13, wherein said air release component includes a hydrophobic membrane.
15. A blood treatment apparatus, comprising:
a blood dialyzer or hemofilter processing element including filter media through which blood passes;
said processing element having a chamber at an exit of a treatment portion thereof where blood flow velocity drops to a low rate, said chamber having at least one outlet;
a holder attachable to a blood treatment machine and configurable to support said processing element in a position and orientation such that air can accumulate in said header chamber in a position remote from said outlet whereby said header chamber is enabled to remove air from blood.
16. Apparatus as in claim 15, wherein said processing element is attached to a fluid circuit and forms a part of a disposable set.
17. Apparatus as in claim 16, wherein said holder is configured to support said filter at an angle with respect to the vertical, as defined with respect to the force of gravity.
18. Apparatus as in claim 15, wherein said holder is configured to support said filter at an angle with respect to the vertical, as defined with respect to the force of gravity.
19. Apparatus as in claim 15, wherein said processing element includes tubular membrane media that are vertically oriented in ordinary use.
20. A blood treatment apparatus, comprising:
a blood processing element including filter media through which blood passes;
said processing element having a header chamber at a position where blood exits a portion of said blood processing element, said header chamber having at least one blood outlet and one auxiliary outlet;
said auxiliary outlet being configured to permit the removal of air accumulated in said header chamber and/or addition and removal of biocompatible non-blood fluid.
21. Apparatus as in claim 20, further comprising a valve connected to said auxiliary port and pre-connected and sterilized together with said blood processing element.
22. Apparatus as in claim 20, further comprising a stopcock connected to said auxiliary port and pre-connected and sterilized together with said blood processing element.
23. Apparatus as in claim 20, further comprising a syringe connected to said auxiliary port and pre-connected and sterilized together with said blood processing element.
24. Apparatus as in claim 20, further comprising a holder configured to orient said blood processing element such that said at least one blood outlet is lower, with respect to a direction of gravity, than said auxiliary outlet.
25. Apparatus as in claim 20, further comprising an gas release component connected to said auxiliary port and pre-connected and sterilized together with said blood processing element, said air release component being configured to permit gas to egress from said header space without permitting blood to egress from said header space.
26. Apparatus as in claim 25, wherein said air release component includes a hydrophobic membrane.
US11/577,126 2004-10-28 2005-09-16 Blood treatment dialyzer/filter design to trap entrained air in a fluid circuit Abandoned US20100096311A1 (en)

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Application Number Priority Date Filing Date Title
US11/577,126 US20100096311A1 (en) 2004-10-28 2005-09-16 Blood treatment dialyzer/filter design to trap entrained air in a fluid circuit

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62286304P 2004-10-28 2004-10-28
US11/577,126 US20100096311A1 (en) 2004-10-28 2005-09-16 Blood treatment dialyzer/filter design to trap entrained air in a fluid circuit
PCT/US2005/036603 WO2006049822A1 (en) 2004-10-28 2005-09-16 Blood treatment dialyzer/filter design to trap entrained air in a fluid circuit

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US20100096311A1 true US20100096311A1 (en) 2010-04-22

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Application Number Title Priority Date Filing Date
US11/577,126 Abandoned US20100096311A1 (en) 2004-10-28 2005-09-16 Blood treatment dialyzer/filter design to trap entrained air in a fluid circuit
US11/163,708 Abandoned US20060091058A1 (en) 2004-10-28 2005-10-27 Blood Treatment Dialyzer/Filter Design to Remove Entrained Gas and Add Medicaments
US11/163,703 Abandoned US20060091057A1 (en) 2004-10-28 2005-10-27 Blood Treatment Dialyzer/Filter Design to Trap and Remove Entrained Gas
US11/163,702 Abandoned US20060091056A1 (en) 2004-10-28 2005-10-27 Blood Treatment Filter Design to Trap Entrained Gas in a Blood Circuit
US12/432,507 Active 2026-03-01 US7901579B2 (en) 2004-10-28 2009-04-29 Blood treatment dialyzer/filter for permitting gas removal
US13/025,306 Abandoned US20110126714A1 (en) 2004-10-28 2011-02-11 Blood treatment dialyzer/filter for permitting gas removal

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US11/163,708 Abandoned US20060091058A1 (en) 2004-10-28 2005-10-27 Blood Treatment Dialyzer/Filter Design to Remove Entrained Gas and Add Medicaments
US11/163,703 Abandoned US20060091057A1 (en) 2004-10-28 2005-10-27 Blood Treatment Dialyzer/Filter Design to Trap and Remove Entrained Gas
US11/163,702 Abandoned US20060091056A1 (en) 2004-10-28 2005-10-27 Blood Treatment Filter Design to Trap Entrained Gas in a Blood Circuit
US12/432,507 Active 2026-03-01 US7901579B2 (en) 2004-10-28 2009-04-29 Blood treatment dialyzer/filter for permitting gas removal
US13/025,306 Abandoned US20110126714A1 (en) 2004-10-28 2011-02-11 Blood treatment dialyzer/filter for permitting gas removal

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WO (1) WO2006049822A1 (en)

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US7901579B2 (en) 2011-03-08
US20060091058A1 (en) 2006-05-04

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