US20090227980A1 - Triggered drug release - Google Patents
Triggered drug release Download PDFInfo
- Publication number
- US20090227980A1 US20090227980A1 US12/398,407 US39840709A US2009227980A1 US 20090227980 A1 US20090227980 A1 US 20090227980A1 US 39840709 A US39840709 A US 39840709A US 2009227980 A1 US2009227980 A1 US 2009227980A1
- Authority
- US
- United States
- Prior art keywords
- drug
- balloon catheter
- coating
- balloon
- expandable portion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/145—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
Definitions
- the present invention relates to various mechanisms and devices for triggering the release of drug from a balloon catheter.
- systemic administration of drug agents treats the body as a whole even though the disease to be treated may be localized.
- systemic administration may not be desirable because the drug agents may have unwanted effects on parts of the body which are not to be treated, or because treatment of the diseased part of the body requires a high concentration of drug agent that may not be achievable by systemic administration.
- the present invention provides a balloon catheter comprising a catheter body having a balloon mounted thereon, the balloon having an outer expandable portion at least partially coated with a pH sensitive coating comprising a drug and a carrier material that is water-soluble at certain pHs but water-insoluble at other pHs.
- the present invention provides a method of releasing drug from the surface of a balloon catheter comprising providing a balloon catheter having an outer expandable portion coated with a pH sensitive coating.
- the pH sensitive coating comprises a drug and a carrier material that is water-soluble at certain pHs but water-insoluble at other pHs.
- the method further comprises exposing the pH sensitive coating to an appropriate pH to render the carrier material water-soluble to thereby allow drug release.
- the present invention provides a method of preventing undesired drug release during delivery of a drug coated balloon catheter comprising providing a balloon catheter having an outer expandable portion coated with a pH sensitive coating
- the coating comprises a drug and a carrier material that is water-soluble at certain pHs but water-insoluble at other pHs.
- the method further comprises inserting the balloon catheter into a lumen and advancing the balloon catheter to the target site while the coating is water-insoluble.
- the method further includes exposing the pH sensitive coating to an appropriate pH once at the target site to render the carrier material water-soluble to thereby allow drug release.
- the present invention provides a balloon catheter comprising a catheter body having a balloon mounted thereon, the balloon having an outer expandable portion at least partially coated with a coating, the coating comprising a pH sensitive hydrogel and a drug, wherein the pH sensitive hydrogel swells at certain pHs but shrinks at other pHs.
- the present invention provides a method of releasing a drug from the surface of a balloon catheter comprising providing a balloon catheter having an expandable portion coated with coating comprising a pH sensitive hydrogel and a drug.
- the pH sensitive hydrogel swells or shrinks with change in pH.
- the method further comprises exposing the coating to an appropriate pH to swell the hydrogel to thereby allow drug release.
- the present invention provides a method of preventing undesired drug release during delivery of a drug coated balloon catheter comprising providing a balloon catheter having an expandable portion coated with coating comprising a pH sensitive hydrogel and a drug.
- the pH sensitive hydrogel swells or shrinks with change in pH.
- the method further comprises inserting the balloon catheter into a lumen and advancing the balloon catheter to the target site while the hydrogel is in a shrunken state.
- the method further includes exposing the pH sensitive coating to an appropriate pH once at the target site to swell the hydrogel to thereby allow drug release.
- the present invention provides a balloon catheter comprising a catheter body having a balloon mounted thereon, the balloon having an outer expandable portion comprising a drug conjugated to a polymer by a hydrolyzable bond.
- the present invention provides a method of releasing a drug from the surface of a balloon catheter comprising providing a balloon catheter having an expandable portion comprising a drug conjugated to a polymer by a hydrolyzable bond. The method further comprises hydrolyzing the bond between the drug and the polymer to release the drug.
- the present invention provides a method of preventing undesired drug release during delivery of a drug coated balloon catheter.
- the method comprises providing a balloon catheter having an expandable portion comprising a drug conjugated to a polymer by a hydrolyzable bond.
- the method further comprises inserting the balloon catheter into a lumen and advancing the balloon catheter to the target site.
- the method further comprises hydrolyzing the bond between the drug and the polymer once at the target site thereby releasing the drug into the target site.
- FIG. 1 is cross-sectional view of an embodiment of a balloon catheter according to the present invention.
- FIG. 2 is a cross-sectional view of an embodiment of a balloon catheter according to the present invention.
- FIG. 2 a is an enlarged cross-sectional view of the balloon portion of a balloon catheter of FIG. 2 showing pores through which a solution can pass to contact the coating on the outer surface of the balloon.
- FIG. 3 is schematic illustration of a coating on a balloon catheter where therapeutic agent is contained within the coating.
- FIG. 4 is a schematic illustration of a coating after the coating is exposed to a triggering agent to activate the coating and release drug therefrom.
- FIG. 5 is an enlarged cross-sectional view of a balloon catheter including a semi-permeable outer balloon and inner balloon.
- FIG. 6 is a further enlarged schematic illustration of a portion of FIG. 5 which shows the manner in which a semi-permeable balloon prevents passage of a drug.
- FIG. 7 is a further enlarged schematic illustration of a portion of FIG. 5 which shows the manner in which a semi-permeable balloon enables passage of a drug.
- FIG. 8 is a much enlarged cross-sectional view of the region C in FIG. 6 of the membrane, illustrating the pathways through the thickness of the membrane.
- the present invention provides devices and methods for delivering drug to a target site via a medical device without the drug prematurely releasing from the medical device during transit to the target site.
- the present invention provides various embodiments where drug is released from a drug coated balloon catheter via a triggering condition.
- the triggering condition can be, for example, a change in solubility, a change in volume, or hydrolysis.
- a triggering agent can bring about the triggering condition.
- a balloon catheter 10 comprises a catheter body 51 having a balloon 20 mounted thereon.
- Balloon 20 has an expandable portion with an outer surface 25 at least partially coated with a coating 30 comprising a carrier material comprising a therapeutic agent.
- a triggering agent can be delivered to coating 30 via a lumen 56 of the catheter 10 .
- the triggering agent passes to the outer surface portion 25 of balloon 20 through opening 53 which is located proximal of the outer surface portion 25 .
- the agent is then carried by the flow of bodily fluids towards outer surface portion 25 where the solution washes over coating 30 .
- Contact of a triggering agent with coating 30 induces the release of therapeutic agent carried by coating 30 .
- a balloon catheter 10 comprises a balloon 20 having a porous interface 57 and a coating 30 at least partially disposed thereon which comprises a carrier material comprising a therapeutic agent.
- Balloon catheter 10 further comprises a lumen 56 , which is in communication with porous interface 57 of balloon 20 .
- a triggering agent delivered through lumen 56 can exit lumen 56 through porous interface 57 to coating 30 .
- a triggering agent can pass directly to coating 30 through catheter 10 .
- Such embodiments are only exemplary and the present invention is not limited to any particular catheter configuration so long as a triggering agent can access coating 30 .
- a therapeutic agent 61 is carried in or on the coating 30 at least partially disposed on the outside surface 25 of balloon 20 of catheter 10 .
- the coating is “activated” to release drug therefrom as shown in FIG. 4 .
- a triggering agent is delivered to a coating on the outside of a balloon catheter using a double membrane catheter.
- a catheter 10 can carry an inner balloon 22 and a porous outer balloon 24 , through which the a triggering agent may pass to coating 30 on outer balloon 24 under conditions of pressure.
- Coating 30 can comprise a drug immobilized therein until released by exposure to a triggering agent.
- the triggering agent can be introduced through a first lumen 26 into an intermediate region 28 (illustrated in FIG. 6 ) between balloons 22 and 24 via a first aperture 53 .
- inflation fluid passes through a second lumen 32 and through port 34 to inflate inner balloon 22 .
- Inflation of inner balloon 22 provides the pressure needed on the solution comprising a triggering agent in intermediate region 28 to effect passage of the solution through openings of porous outer balloon 24 .
- inner balloon 22 can be deflated and intermediate region 28 can be re-filled with drug, which can then be delivered to coating 30 to replenish it.
- the process of replenishing coating 30 with drug and delivering a triggering agent to coating 30 to induce the release of drug from coating 30 may be repeated as many times as desired.
- the inner balloon may be of the type used in dilatation of blood vessels and made, for example, of a somewhat compliant material such as polyethylene that conforms to the shape of the body lumen wall or a nondistendable material such as PET.
- At least a portion of the outer balloon may include a membrane selected to create sufficient resistance so that the triggering agent or drug weeps out of the membrane and into the coating. This gentle application is advantageous since injury or disruption of the vessel wall is avoided.
- the membrane has at least one layer of hydrophobic material having small openings, for example, 2.20 microns, to create a large pressure drop across the membrane to dissipate the pressure applied to the triggering agent in the intermediate region during balloon inflation and effect a low-energy weeping delivery of the triggering agent.
- the small openings Prior to pressuring the triggering agent, the small openings can prevent the flow of the triggering agent from the intermediate region (or the contamination of the intermediate region with body fluid from the body lumen) as further discussed below.
- porous outer balloon 24 can include a series of tortuous paths 34 through its thickness connecting openings 36 on its inner surface exposed to the region 28 and openings 38 exposed to the body lumen.
- the flow of triggering agent through the pathways can reduce the velocity of the triggering agent and enables gentle application to the coating and then to the tissue.
- Suitable materials for the porous outer balloon or a porous membrane of the outer balloon include, but are not limited to, GORETEXTM (an expanded porous fluorocarbon plastic material) and ultrahigh molecular weight microporous polyethylene (a polyethylene material available through Millipore, Inc. and commonly used for filter membranes).
- Either the entire balloon 24 is formed from the semi-permeable material or a patch of the material is attached to a normal balloon e.g. by heat sealing.
- Other semi-permeable membranes may be formed by providing relatively large, substantially straight pathways through a hydrogel material and applying thereover, on the outside of the membrane, a hydrogel, e.g., of polyacrylic acid of the type described in U.S. Pat. No. 297,331, filed Jan. 17, 1989, the entire contents of which are incorporated herein by reference.
- Low energy application may also be achieved by a porous material formed of a series of layers having offset openings or a series of woven layers, which create a tortuous pathway for passage of a solution.
- the semi-permeable material is hydrophobic with openings of a size selected to prevent substantial flow of solutions from the region 28 until sufficient pressure is applied.
- the water intrusion pressure of the permeable hydrophobic material and that of the solution are selected such that the solution will not normally pass through the openings unless sufficient pressure is applied by inner balloon 22 .
- Selection of the proper intrusion pressure for the semi-permeable material of outer balloon 24 prevents passage of the drug or triggering agent 16 through the openings of outer balloon 24 when the balloon is less than fully inflated.
- the triggering agent or drug 16 passes through the openings in a low-pressure, low-energy, non-injurious manner.
- Inner balloon 22 may be deflated, and the device may be refilled with a triggering agent, if necessary, and moved to various locations, where inner balloon 22 is re-inflated to deliver the triggering agent or drug, or another drug altogether to the various locations. This process may be repeated.
- a constant pressure pump may be used to maintain the balloon pressure above that needed to administer a solution through the openings during treatment. It will be understood that the amount of the triggering agent or drug delivered may also be carefully controlled by application of sufficient pressure to enable administration, then reducing the pressure below the threshold for passage through the openings, at which point, delivery of solution to the coating ceases.
- the procedure can be performed in many body lumens, most preferably, the vascular system in which case dilatation of a stenosed blood vessel may be carried out before, after or simultaneously with drug application.
- a coating of a balloon catheter is a pH sensitive coating comprising therapeutic agent dispersed or otherwise contained within a carrier material that is water-soluble at certain pHs but water-insoluble at other pHs.
- carrier materials include fatty acids and citric acid that are water-soluble at basic pHs but water-insoluble at neutral or acidic pHs, bases such as amines that are water-soluble at acidic pHs but water-insoluble at neutral or basic pHs, and polymers of which the solubility changes with pH.
- Non-limiting examples of such polymers include sulfonamide-based polymers and copolymers, amine functional polymers such as polyvinyl pyridine polymers and copolymers, and polysaccharides such as chitosan that are water-soluble at acidic pHs but water-insoluble at neutral or basic pHs and poly (vinylpyrrolidone-co-dimethylmaleic anhydride) (PVD) that is water-soluble at neutral and acidic pHs but water-insoluble at basic pHs.
- PVD poly (vinylpyrrolidone-co-dimethylmaleic anhydride)
- the drug can be dispersed or otherwise placed in the carrier material at a pH at which the carrier material is water-insoluble, for example, and the resultant coating can be applied to the at least a portion of the outer expandable portion of the balloon catheter.
- the balloon catheter can then be inserted into a lumen of the body and delivered to the target site. During the delivery, the carrier material can be kept water-insoluble.
- the balloon can be inflated, and the pH can be changed to render the carrier material water-soluble, thereby allowing release of the drug.
- the pH change causes formation of a salt, which renders the carrier material water-soluble.
- a polymer is used as a carrier, because the polymer dissolves at certain pHs, upon exposure to the appropriate pH and release of the drug, the polymer dissolves in the bloodstream.
- the drug can be dispersed or otherwise placed in the hydrogel before or after the hydrogel-containing coating is applied to the outer expandable portion of the balloon catheter.
- the balloon catheter can then be inserted into a lumen of the body and delivered to the target site. During the delivery, the hydrogel can be kept at its shrunken state.
- the balloon can be inflated, and the pH can be changed to swell the hydrogel, thereby allowing release of the drug.
- the triggering condition is hydrolysis and the triggering agent is an agent capable of hydrolyzing a drug.
- a drug is attached to an outer expandable portion of a balloon catheter via a hydrolyzable bond, such as an ester bond, such that the hydrolyzable bond is cleaved by exposure to a triggering agent.
- a hydrolyzable bond such as an ester bond
- One way of achieving this is by conjugating a drug with a hydroxyl group to a polymer on the surface of the balloon with a free carboxylic acid group to form an ester bond between the carboxylic acid of the polymer and the hydroxyl group of the drug.
- the expandable portion itself is fabricated from a polymer that can form a hydrolyzable bond with a drug.
- Non-limiting examples of such a polymer include polyglutamic acid and polylactic acid.
- the balloon catheter can then be inserted into a lumen of the body and delivered to the target site. During the delivery, the hydrolyzable bond can be kept intact. Once at the target site, the balloon can be inflated, and the bond is hydrolyzed, thereby allowing release of the drug.
- the bond could be hydrolyzed in a number of ways, such as, for example, exposure to a catalyst or a change in pH around the ester bond.
- a non-limiting example of a catalyst is polyoxomethylate.
- the catalyst can also be an enzyme found in the body such as an esterase, which is found in blood.
- the catalyst can be delivered to the surface of the outer expandable portion of the balloon catheter via a lumen as described above.
- a change in pH for any of the embodiments described above could be initiated chemically by delivering a basic or acidic solution to the site or electrochemically by water electrolysis.
- an electrode can be the cutting blades on a balloon catheter or the entire or partial surface of the balloon coated with a conductive material.
- a conductive material include metals, such as gold and platinum, and conductive polymers such as polypyrrole, poly (3,4-ethylene-dioxythiphene) (PEDOT), poly acetylene, and polyaniline.
- a current could be applied anodically at the site to electrochemically convert water surrounding the balloon to oxygen gas and hydrogen ions, thereby creating an acidic condition.
- a current could be applied cathodically at the site to electrochemically convert water surrounding the balloon to hydrogen gas and hydroxyl ions, thereby creating a basic condition.
- the current could be applied during the delivery of the balloon catheter to keep the local pH at a desired level to prevent the release of the drug.
- the current could be applied at the target site to obtain a desired pH to release the drug.
- the therapeutic agent that is applied to the outer expandable portion of a balloon catheter of the present invention can be any suitable biologically acceptable agent such as a non-genetic therapeutic agent, a biomolecule, a small molecule, or cells.
- the therapeutic agent can be pharmaceutically active compound.
- Non-limiting examples of therapeutic agents include anti-thrombogenic agents, anti-proliferative agents, anti-inflammatory agents, anti-neoplastic/anti-proliferative/anti-mitotic agents, anti-microbial agents, biofilm synthesis inhibitors, antibiotics, antibodies, anesthetic agents, nitric oxide, nitric oxide (NO) donors, anti-coagulants, vascular cell growth promoters, vascular cell growth inhibitors, cholesterol-lowering agents, vasodilating agents, agents which interfere with endogenous vasoactive mechanisms, inhibitors of heat shock proteins angiotensin converting enzyme (ACE) inhibitors, beta-blockers, ⁇ AR kinase ( ⁇ ARK) inhibitors, phospholamban inhibitors, protein-bound particle drugs, and any suitable combination thereof.
- Non-limiting examples of specific drugs include taxol, enoxaparin, sirolimus, tacrolimus, everolimus, zotarolimus, angiopeptin, and combinations thereof.
Abstract
Methods and devices for triggering drug release from the outer expandable portion of a balloon catheter are provided. Drug is released from a drug coated balloon catheter via a triggering condition. The triggering condition can be a change in solubility or volume or hydrolysis.
Description
- The present application claims priority to U.S. provisional application Ser. No. 61/034,217 filed Mar. 6, 2008, the disclosure of which is incorporated herein by reference in its entirety.
- The present invention relates to various mechanisms and devices for triggering the release of drug from a balloon catheter.
- The systemic administration of drug agents, such as by transoral or intravenous means, treats the body as a whole even though the disease to be treated may be localized. In such a case, systemic administration may not be desirable because the drug agents may have unwanted effects on parts of the body which are not to be treated, or because treatment of the diseased part of the body requires a high concentration of drug agent that may not be achievable by systemic administration.
- It is therefore often desirable to administer drug agents at localized sites within the body. Common examples include cases of localized disease (e.g., heart disease) or occluded body lumens. Various methods have been proposed for such localized drug administration. For example, U.S. Pat. No. 5,304,121, which is incorporated herein by reference, describes a method of delivering water-soluble drugs to tissue at desired locations of a body lumen wall. The method generally includes the steps of impregnating a hydrogel polymer on a balloon catheter with an aqueous drug solution, inserting the catheter into a blood vessel to a desired location, and expanding the catheter balloon against the surrounding tissue to allow the release of the drug. One of the potential drawbacks to conventional drug delivery techniques using drug-impregnated polymer coatings on balloon catheters is the possible premature diffusion of the drug out of the coating during delivery into the body. Two solutions to this problem have been proposed: the use of a removable sheath over the polymer coating, and the use of a dissolvable or meltable temporary coating over the polymer coating to protect and retain the drug agent in the coating prior to a time of desired administration at a target location. The sheath approach, however, adds considerable profile to the balloon catheter device, making access to small body lumens difficult or impracticable. Furthermore, the use of a temporary protective coating over a drug-impregnated polymer coating may place undesirable time constraints on the drug delivery procedure. Moreover, it is difficult to identify or develop temporary coatings that permit the release of the drug in a consistent and predictable manner.
- In view of the potential drawbacks to conventional drug delivery techniques, there exists a need for a device and method for the controlled, localized delivery of drug agents to target locations within a mammalian body while avoiding the premature release of drug agent during delivery.
- In an embodiment, the present invention provides a balloon catheter comprising a catheter body having a balloon mounted thereon, the balloon having an outer expandable portion at least partially coated with a pH sensitive coating comprising a drug and a carrier material that is water-soluble at certain pHs but water-insoluble at other pHs.
- In an embodiment, the present invention provides a method of releasing drug from the surface of a balloon catheter comprising providing a balloon catheter having an outer expandable portion coated with a pH sensitive coating. The pH sensitive coating comprises a drug and a carrier material that is water-soluble at certain pHs but water-insoluble at other pHs. The method further comprises exposing the pH sensitive coating to an appropriate pH to render the carrier material water-soluble to thereby allow drug release.
- In another embodiment, the present invention provides a method of preventing undesired drug release during delivery of a drug coated balloon catheter comprising providing a balloon catheter having an outer expandable portion coated with a pH sensitive coating The coating comprises a drug and a carrier material that is water-soluble at certain pHs but water-insoluble at other pHs. The method further comprises inserting the balloon catheter into a lumen and advancing the balloon catheter to the target site while the coating is water-insoluble. The method further includes exposing the pH sensitive coating to an appropriate pH once at the target site to render the carrier material water-soluble to thereby allow drug release.
- In an embodiment, the present invention provides a balloon catheter comprising a catheter body having a balloon mounted thereon, the balloon having an outer expandable portion at least partially coated with a coating, the coating comprising a pH sensitive hydrogel and a drug, wherein the pH sensitive hydrogel swells at certain pHs but shrinks at other pHs.
- In another embodiment, the present invention provides a method of releasing a drug from the surface of a balloon catheter comprising providing a balloon catheter having an expandable portion coated with coating comprising a pH sensitive hydrogel and a drug. The pH sensitive hydrogel swells or shrinks with change in pH. The method further comprises exposing the coating to an appropriate pH to swell the hydrogel to thereby allow drug release.
- In another embodiment, the present invention provides a method of preventing undesired drug release during delivery of a drug coated balloon catheter comprising providing a balloon catheter having an expandable portion coated with coating comprising a pH sensitive hydrogel and a drug. The pH sensitive hydrogel swells or shrinks with change in pH. The method further comprises inserting the balloon catheter into a lumen and advancing the balloon catheter to the target site while the hydrogel is in a shrunken state. The method further includes exposing the pH sensitive coating to an appropriate pH once at the target site to swell the hydrogel to thereby allow drug release.
- In an embodiment, the present invention provides a balloon catheter comprising a catheter body having a balloon mounted thereon, the balloon having an outer expandable portion comprising a drug conjugated to a polymer by a hydrolyzable bond.
- In another embodiment, the present invention provides a method of releasing a drug from the surface of a balloon catheter comprising providing a balloon catheter having an expandable portion comprising a drug conjugated to a polymer by a hydrolyzable bond. The method further comprises hydrolyzing the bond between the drug and the polymer to release the drug.
- In another embodiment, the present invention provides a method of preventing undesired drug release during delivery of a drug coated balloon catheter. The method comprises providing a balloon catheter having an expandable portion comprising a drug conjugated to a polymer by a hydrolyzable bond. The method further comprises inserting the balloon catheter into a lumen and advancing the balloon catheter to the target site. The method further comprises hydrolyzing the bond between the drug and the polymer once at the target site thereby releasing the drug into the target site.
-
FIG. 1 is cross-sectional view of an embodiment of a balloon catheter according to the present invention. -
FIG. 2 is a cross-sectional view of an embodiment of a balloon catheter according to the present invention. -
FIG. 2 a is an enlarged cross-sectional view of the balloon portion of a balloon catheter ofFIG. 2 showing pores through which a solution can pass to contact the coating on the outer surface of the balloon. -
FIG. 3 is schematic illustration of a coating on a balloon catheter where therapeutic agent is contained within the coating. -
FIG. 4 is a schematic illustration of a coating after the coating is exposed to a triggering agent to activate the coating and release drug therefrom. -
FIG. 5 is an enlarged cross-sectional view of a balloon catheter including a semi-permeable outer balloon and inner balloon. -
FIG. 6 is a further enlarged schematic illustration of a portion ofFIG. 5 which shows the manner in which a semi-permeable balloon prevents passage of a drug. -
FIG. 7 is a further enlarged schematic illustration of a portion ofFIG. 5 which shows the manner in which a semi-permeable balloon enables passage of a drug. -
FIG. 8 is a much enlarged cross-sectional view of the region C inFIG. 6 of the membrane, illustrating the pathways through the thickness of the membrane. - The present invention provides devices and methods for delivering drug to a target site via a medical device without the drug prematurely releasing from the medical device during transit to the target site. Specifically, the present invention provides various embodiments where drug is released from a drug coated balloon catheter via a triggering condition. The triggering condition can be, for example, a change in solubility, a change in volume, or hydrolysis. A triggering agent can bring about the triggering condition.
- Referring to
FIG. 1 , in certain embodiments, aballoon catheter 10 comprises acatheter body 51 having aballoon 20 mounted thereon.Balloon 20 has an expandable portion with anouter surface 25 at least partially coated with acoating 30 comprising a carrier material comprising a therapeutic agent. A triggering agent can be delivered to coating 30 via alumen 56 of thecatheter 10. Specifically, in an embodiment, the triggering agent passes to theouter surface portion 25 ofballoon 20 throughopening 53 which is located proximal of theouter surface portion 25. The agent is then carried by the flow of bodily fluids towardsouter surface portion 25 where the solution washes over coating 30. Contact of a triggering agent withcoating 30 induces the release of therapeutic agent carried by coating 30. - Referring to
FIG. 2 , in another embodiment, aballoon catheter 10 comprises aballoon 20 having aporous interface 57 and acoating 30 at least partially disposed thereon which comprises a carrier material comprising a therapeutic agent.Balloon catheter 10 further comprises alumen 56, which is in communication withporous interface 57 ofballoon 20. Referring toFIG. 2 a, a triggering agent delivered throughlumen 56 can exitlumen 56 throughporous interface 57 tocoating 30. In the absence oflumen 56, a triggering agent can pass directly to coating 30 throughcatheter 10. Such embodiments are only exemplary and the present invention is not limited to any particular catheter configuration so long as a triggering agent can accesscoating 30. - Referring to
FIG. 3 and as described in general above, atherapeutic agent 61 is carried in or on thecoating 30 at least partially disposed on theoutside surface 25 ofballoon 20 ofcatheter 10. When coating 30 is exposed to an appropriate triggering agent, the coating is “activated” to release drug therefrom as shown inFIG. 4 . - Referring to
FIGS. 5 and 6 , in certain embodiments, a triggering agent is delivered to a coating on the outside of a balloon catheter using a double membrane catheter. For example, acatheter 10 can carry aninner balloon 22 and a porousouter balloon 24, through which the a triggering agent may pass to coating 30 onouter balloon 24 under conditions of pressure.Coating 30 can comprise a drug immobilized therein until released by exposure to a triggering agent. The triggering agent can be introduced through afirst lumen 26 into an intermediate region 28 (illustrated inFIG. 6 ) betweenballoons first aperture 53. At the time of dilatation, inflation fluid passes through asecond lumen 32 and throughport 34 to inflateinner balloon 22. Inflation ofinner balloon 22 provides the pressure needed on the solution comprising a triggering agent inintermediate region 28 to effect passage of the solution through openings of porousouter balloon 24. After release of the drug from coating 30 is triggered by the triggering agent,inner balloon 22 can be deflated andintermediate region 28 can be re-filled with drug, which can then be delivered tocoating 30 to replenish it. The process of replenishingcoating 30 with drug and delivering a triggering agent to coating 30 to induce the release of drug from coating 30 may be repeated as many times as desired. - The inner balloon may be of the type used in dilatation of blood vessels and made, for example, of a somewhat compliant material such as polyethylene that conforms to the shape of the body lumen wall or a nondistendable material such as PET. At least a portion of the outer balloon may include a membrane selected to create sufficient resistance so that the triggering agent or drug weeps out of the membrane and into the coating. This gentle application is advantageous since injury or disruption of the vessel wall is avoided. Preferably, the membrane has at least one layer of hydrophobic material having small openings, for example, 2.20 microns, to create a large pressure drop across the membrane to dissipate the pressure applied to the triggering agent in the intermediate region during balloon inflation and effect a low-energy weeping delivery of the triggering agent. Prior to pressuring the triggering agent, the small openings can prevent the flow of the triggering agent from the intermediate region (or the contamination of the intermediate region with body fluid from the body lumen) as further discussed below.
- Referring to
FIG. 8 , porousouter balloon 24 can include a series oftortuous paths 34 through itsthickness connecting openings 36 on its inner surface exposed to theregion 28 andopenings 38 exposed to the body lumen. The flow of triggering agent through the pathways can reduce the velocity of the triggering agent and enables gentle application to the coating and then to the tissue. Suitable materials for the porous outer balloon or a porous membrane of the outer balloon include, but are not limited to, GORETEX™ (an expanded porous fluorocarbon plastic material) and ultrahigh molecular weight microporous polyethylene (a polyethylene material available through Millipore, Inc. and commonly used for filter membranes). Either theentire balloon 24 is formed from the semi-permeable material or a patch of the material is attached to a normal balloon e.g. by heat sealing. Other semi-permeable membranes may be formed by providing relatively large, substantially straight pathways through a hydrogel material and applying thereover, on the outside of the membrane, a hydrogel, e.g., of polyacrylic acid of the type described in U.S. Pat. No. 297,331, filed Jan. 17, 1989, the entire contents of which are incorporated herein by reference. Low energy application may also be achieved by a porous material formed of a series of layers having offset openings or a series of woven layers, which create a tortuous pathway for passage of a solution. - Preferably, the semi-permeable material is hydrophobic with openings of a size selected to prevent substantial flow of solutions from the
region 28 until sufficient pressure is applied. Referring toFIGS. 6 and 7 , the water intrusion pressure of the permeable hydrophobic material and that of the solution are selected such that the solution will not normally pass through the openings unless sufficient pressure is applied byinner balloon 22. Selection of the proper intrusion pressure for the semi-permeable material ofouter balloon 24 prevents passage of the drug or triggeringagent 16 through the openings ofouter balloon 24 when the balloon is less than fully inflated. - As demonstrated in
FIG. 7 , under conditions of sufficiently high intrusion pressure (e.g., with the balloon fully inflated), the triggering agent ordrug 16 passes through the openings in a low-pressure, low-energy, non-injurious manner.Inner balloon 22 may be deflated, and the device may be refilled with a triggering agent, if necessary, and moved to various locations, whereinner balloon 22 is re-inflated to deliver the triggering agent or drug, or another drug altogether to the various locations. This process may be repeated. A constant pressure pump may be used to maintain the balloon pressure above that needed to administer a solution through the openings during treatment. It will be understood that the amount of the triggering agent or drug delivered may also be carefully controlled by application of sufficient pressure to enable administration, then reducing the pressure below the threshold for passage through the openings, at which point, delivery of solution to the coating ceases. - The procedure can be performed in many body lumens, most preferably, the vascular system in which case dilatation of a stenosed blood vessel may be carried out before, after or simultaneously with drug application.
- In certain embodiments, a coating of a balloon catheter is a pH sensitive coating comprising therapeutic agent dispersed or otherwise contained within a carrier material that is water-soluble at certain pHs but water-insoluble at other pHs. Non-limiting examples of such carrier materials include fatty acids and citric acid that are water-soluble at basic pHs but water-insoluble at neutral or acidic pHs, bases such as amines that are water-soluble at acidic pHs but water-insoluble at neutral or basic pHs, and polymers of which the solubility changes with pH. Non-limiting examples of such polymers include sulfonamide-based polymers and copolymers, amine functional polymers such as polyvinyl pyridine polymers and copolymers, and polysaccharides such as chitosan that are water-soluble at acidic pHs but water-insoluble at neutral or basic pHs and poly (vinylpyrrolidone-co-dimethylmaleic anhydride) (PVD) that is water-soluble at neutral and acidic pHs but water-insoluble at basic pHs. One of ordinary skill in the art could readily determine other carrier materials that are water-insoluble at certain pHs but water-soluble at other pHs. The drug can be dispersed or otherwise placed in the carrier material at a pH at which the carrier material is water-insoluble, for example, and the resultant coating can be applied to the at least a portion of the outer expandable portion of the balloon catheter. The balloon catheter can then be inserted into a lumen of the body and delivered to the target site. During the delivery, the carrier material can be kept water-insoluble. Once at the target site, the balloon can be inflated, and the pH can be changed to render the carrier material water-soluble, thereby allowing release of the drug. For example, when an acid or a base is used as a carrier, the pH change causes formation of a salt, which renders the carrier material water-soluble. When a polymer is used as a carrier, because the polymer dissolves at certain pHs, upon exposure to the appropriate pH and release of the drug, the polymer dissolves in the bloodstream.
- In certain embodiments, a coating of a balloon catheter is a coating comprising a pH sensitive hydrogel and therapeutic agent dispersed or otherwise contained within the hydrogel. The volume of the hydrogel changes, i.e. the hydrogel swells or shrinks, with pH. Non-limiting examples of a suitable hydrogel include carboxylic acid functional polymers such as acrylic polymers incorporating acrylic and/or methacrylic acid, poly(ethylene imine), poly(propylene imine), chitosan, poly(L-lysine), and poly(L-histidine). One of ordinary skill in the art could readily determine other hydrogels that are pH sensitive. The drug can be dispersed or otherwise placed in the hydrogel before or after the hydrogel-containing coating is applied to the outer expandable portion of the balloon catheter. The balloon catheter can then be inserted into a lumen of the body and delivered to the target site. During the delivery, the hydrogel can be kept at its shrunken state. Once at the target site, the balloon can be inflated, and the pH can be changed to swell the hydrogel, thereby allowing release of the drug.
- In another embodiment, the triggering condition is hydrolysis and the triggering agent is an agent capable of hydrolyzing a drug. For example, in certain embodiments, a drug is attached to an outer expandable portion of a balloon catheter via a hydrolyzable bond, such as an ester bond, such that the hydrolyzable bond is cleaved by exposure to a triggering agent. One way of achieving this is by conjugating a drug with a hydroxyl group to a polymer on the surface of the balloon with a free carboxylic acid group to form an ester bond between the carboxylic acid of the polymer and the hydroxyl group of the drug. Alternatively, the expandable portion itself is fabricated from a polymer that can form a hydrolyzable bond with a drug. Non-limiting examples of such a polymer include polyglutamic acid and polylactic acid. The balloon catheter can then be inserted into a lumen of the body and delivered to the target site. During the delivery, the hydrolyzable bond can be kept intact. Once at the target site, the balloon can be inflated, and the bond is hydrolyzed, thereby allowing release of the drug. The bond could be hydrolyzed in a number of ways, such as, for example, exposure to a catalyst or a change in pH around the ester bond. Regarding exposure to a catalyst, a non-limiting example of a catalyst is polyoxomethylate. The catalyst can also be an enzyme found in the body such as an esterase, which is found in blood. The catalyst can be delivered to the surface of the outer expandable portion of the balloon catheter via a lumen as described above.
- A change in pH for any of the embodiments described above could be initiated chemically by delivering a basic or acidic solution to the site or electrochemically by water electrolysis. For electrochemical pH change, an electrode can be the cutting blades on a balloon catheter or the entire or partial surface of the balloon coated with a conductive material. Non-limiting examples of such a conductive material include metals, such as gold and platinum, and conductive polymers such as polypyrrole, poly (3,4-ethylene-dioxythiphene) (PEDOT), poly acetylene, and polyaniline. A current could be applied anodically at the site to electrochemically convert water surrounding the balloon to oxygen gas and hydrogen ions, thereby creating an acidic condition. Alternatively, a current could be applied cathodically at the site to electrochemically convert water surrounding the balloon to hydrogen gas and hydroxyl ions, thereby creating a basic condition. The current could be applied during the delivery of the balloon catheter to keep the local pH at a desired level to prevent the release of the drug. The current could be applied at the target site to obtain a desired pH to release the drug.
- The therapeutic agent that is applied to the outer expandable portion of a balloon catheter of the present invention can be any suitable biologically acceptable agent such as a non-genetic therapeutic agent, a biomolecule, a small molecule, or cells. For example, the therapeutic agent can be pharmaceutically active compound. Non-limiting examples of therapeutic agents include anti-thrombogenic agents, anti-proliferative agents, anti-inflammatory agents, anti-neoplastic/anti-proliferative/anti-mitotic agents, anti-microbial agents, biofilm synthesis inhibitors, antibiotics, antibodies, anesthetic agents, nitric oxide, nitric oxide (NO) donors, anti-coagulants, vascular cell growth promoters, vascular cell growth inhibitors, cholesterol-lowering agents, vasodilating agents, agents which interfere with endogenous vasoactive mechanisms, inhibitors of heat shock proteins angiotensin converting enzyme (ACE) inhibitors, beta-blockers, βAR kinase (βARK) inhibitors, phospholamban inhibitors, protein-bound particle drugs, and any suitable combination thereof. Non-limiting examples of specific drugs include taxol, enoxaparin, sirolimus, tacrolimus, everolimus, zotarolimus, angiopeptin, and combinations thereof.
- The foregoing description and examples have been set forth merely to illustrate the invention and are not intended as being limiting. Each of the disclosed aspects and embodiments of the present invention may be considered individually or in combination with other aspects, embodiments, and variations of the invention. Further, while certain features of embodiments of the present invention may be shown in only certain figures, such features can be incorporated into other embodiments shown in other figures while remaining within the scope of the present invention. In addition, unless otherwise specified, none of the steps of the methods of the present invention are confined to any particular order of performance. Modifications of the disclosed embodiments incorporating the spirit and substance of the invention may occur to persons skilled in the art and such modifications are within the scope of the present invention. Furthermore, all references cited herein are incorporated by reference in their entirety.
Claims (31)
1. A method of releasing drug from the surface of a balloon catheter comprising:
providing a balloon catheter having an outer expandable portion at least partially coated with a pH sensitive coating, the coating comprising a drug and a carrier material that is water-insoluble at certain pHs but water-soluble at other pHs; and
exposing the pH sensitive coating to an appropriate pH to render the carrier material water-soluble to thereby allow drug release.
2. The method of claim 1 , wherein the carrier material is a fatty acid or citric acid.
3. The method of claim 1 , wherein the carrier material is an amine or a compound with at least one amine functional group.
4. The method of claim 1 , wherein the carrier material is a polymer.
5. The method of claim 1 , further comprising changing the pH by delivering an acid or basic solution to the site.
6. The method of claim 1 , further comprising changing the pH electrochemically.
7. The method of claim 6 , wherein the outer expandable portion is entirely or partially coated with a conductive material and function as at least one electrode.
8. A method of preventing undesired drug release during delivery of a drug coated balloon catheter to a target site comprising:
providing a balloon catheter having an outer expandable portion at least partially coated with a pH sensitive coating, the coating comprising a drug and a carrier material that is water-insoluble at certain pHs but water-soluble at other pHs;
inserting the balloon catheter into a lumen and advancing the balloon catheter to the target site while the coating is water-insoluble; and
exposing the pH sensitive coating to an appropriate pH once at the target site to render the carrier material water-soluble to thereby allow drug release.
9. A method of releasing drug from the surface of a balloon catheter comprising:
providing a balloon catheter having an outer expandable portion at least partially coated with a coating, the coating comprising a pH sensitive hydrogel and a drug; and
exposing the pH sensitive hydrogel to an appropriate pH to swell the hydrogel to thereby allow drug release.
10. The method of claim 9 , wherein the hydrogel is selected from acrylic polymers incorporating acrylic and/or methacrylic acid, poly(ethylene imine), poly(propylene imine), chitosan, poly(L-lysine), and poly(L-histidine).
11. The method of claim 9 , further comprising changing the pH by delivering an acid or basic solution to the site.
12. The method of claim 9 , further comprising changing the pH electrochemically.
13. The method of claim 12 , wherein the outer expandable portion is entirely or partially coated with a conductive material and function as at least one electrode.
14. A method of preventing undesired drug release during delivery of a drug coated balloon catheter to a target site comprising:
providing a balloon catheter having an outer expandable portion at least partially coated with a coating, the coating comprising a pH sensitive hydrogel and a drug;
inserting the balloon catheter into a lumen and advancing the balloon catheter to the target site while the hydrogel is at its shrunken state; and
exposing the pH sensitive hydrogel to an appropriate pH to swell the hydrogel to thereby allow drug release.
15. A method of releasing drug from the surface of a balloon catheter comprising:
providing a balloon catheter having an outer expandable portion comprising a drug conjugated to a polymer by a hydrolyzable bond; and
hydrolyzing the bond between the drug and the polymer thereby releasing the drug.
16. The method of claim 15 , wherein the outer expandable portion of the balloon catheter is fabricated from the polymer.
17. The method of claim 15 , wherein the outer expandable portion is at least partially coated with a coating comprising the drug conjugated to the polymer.
18. The method of claim 15 , wherein the bond is an ester bond.
19. The method of claim 15 , wherein the first polymer is polyglutamic acid or polylactic acid.
20. The method of claim 15 , wherein the bond is hydrolyzed by exposure to a catalyst.
21. The method of claim 20 , wherein the catalyst is a polyoxomethylate.
22. The method of claim 20 , wherein the catalyst is an enzyme.
23. The method of claim 22 , wherein the enzyme is an esterase.
24. The method of claim 15 , wherein the bond is hydrolyzed by exposure to a change in pH.
25. The method of claim 24 , wherein the pH is changed by delivering an acid or basic solution to the site.
26. The method of claim 24 , wherein the pH is changed electrochemically.
27. The method of claim 26 , wherein the outer expandable portion is entirely or partially coated with a conductive material and function as at least one electrode.
28. A method of preventing undesired drug release during delivery of a drug coated balloon catheter comprising:
providing a balloon catheter having an outer expandable portion comprising a drug conjugated to a polymer by a hydrolyzable bond;
inserting the balloon catheter into a lumen and advancing the balloon catheter to the target site;
hydrolyzing the bond between the drug and the polymer once at the target site thereby releasing the drug into the target site.
29. A balloon catheter comprising:
a catheter body having a balloon mounted thereon, the balloon having an outer expandable portion at least partially coated with a pH sensitive coating, the pH sensitive coating comprising a drug and a carrier material, the carrier material being water-soluble at certain pHs but water-insoluble at other pHs.
30. A balloon catheter comprising:
a catheter body having a balloon mounted thereon, the balloon having an outer expandable portion at least partially coated with a coating, the coating comprising a pH sensitive hydrogel and a drug, wherein the pH sensitive hydrogel swells at certain pHs but shrinks at other pHs.
31. A balloon catheter comprising:
a catheter body having a balloon mounted thereon, the balloon having an outer expandable portion comprising a drug conjugated to a polymer by a hydrolyzable bond.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/398,407 US20090227980A1 (en) | 2008-03-06 | 2009-03-05 | Triggered drug release |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3421708P | 2008-03-06 | 2008-03-06 | |
US12/398,407 US20090227980A1 (en) | 2008-03-06 | 2009-03-05 | Triggered drug release |
Publications (1)
Publication Number | Publication Date |
---|---|
US20090227980A1 true US20090227980A1 (en) | 2009-09-10 |
Family
ID=40637220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/398,407 Abandoned US20090227980A1 (en) | 2008-03-06 | 2009-03-05 | Triggered drug release |
Country Status (4)
Country | Link |
---|---|
US (1) | US20090227980A1 (en) |
EP (1) | EP2265316B1 (en) |
JP (1) | JP2011513000A (en) |
WO (1) | WO2009111608A1 (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090157167A1 (en) * | 2007-12-18 | 2009-06-18 | Bahler Clinton D | Method of promoting cell proliferation and ingrowth by injury to the native tissue |
US8489192B1 (en) | 2008-02-15 | 2013-07-16 | Holaira, Inc. | System and method for bronchial dilation |
US8597720B2 (en) | 2007-01-21 | 2013-12-03 | Hemoteq Ag | Medical product for treating stenosis of body passages and for preventing threatening restenosis |
US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
US8740895B2 (en) | 2009-10-27 | 2014-06-03 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US8808280B2 (en) | 2008-05-09 | 2014-08-19 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8889211B2 (en) | 2010-09-02 | 2014-11-18 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
WO2015032411A1 (en) | 2013-09-04 | 2015-03-12 | Danmarks Tekniske Universitet | Enzyme triggered release of bioactive agents by live cells |
US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
US9149328B2 (en) | 2009-11-11 | 2015-10-06 | Holaira, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
US9339618B2 (en) | 2003-05-13 | 2016-05-17 | Holaira, Inc. | Method and apparatus for controlling narrowing of at least one airway |
US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
US20170232228A1 (en) * | 2010-02-04 | 2017-08-17 | Procept Biorobotics Corporation | Prostate treatment apparatus |
US9937255B2 (en) | 2011-05-18 | 2018-04-10 | Nectero Medical, Inc. | Coated balloons for blood vessel stabilization |
US10080821B2 (en) | 2009-07-17 | 2018-09-25 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
CN112244925A (en) * | 2020-10-26 | 2021-01-22 | 河北爱能生物科技股份有限公司 | Composite chitosan uterine cavity hemostatic balloon and preparation method thereof |
US11065470B2 (en) | 2014-06-24 | 2021-07-20 | Procept Biorobotics Corporation | Tissue sampling and catheter selection cancer treatment methods |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5945544B2 (en) * | 2010-10-06 | 2016-07-05 | タリス バイオメディカル エルエルシー | Time-selective bioabsorbable or disintegratable drug delivery system and method |
JP6162932B2 (en) * | 2012-06-29 | 2017-07-12 | フクダ電子株式会社 | Balloon catheter and balloon catheter manufacturing method |
US10792477B2 (en) | 2016-02-08 | 2020-10-06 | Orbusneich Medical Pte. Ltd. | Drug eluting balloon |
CN108601930B (en) * | 2016-02-08 | 2021-12-14 | 祥丰医疗私人有限公司 | Drug eluting balloon |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US5547472A (en) * | 1994-01-20 | 1996-08-20 | Terumo Kabushiki Kaisha | Catheter with medicament injection pores |
US6123718A (en) * | 1998-11-02 | 2000-09-26 | Polymerex Medical Corp. | Balloon catheter |
US20030114791A1 (en) * | 1990-12-28 | 2003-06-19 | Arthur Rosenthal | Triggered release hydrogel drug delivery system |
US20050154445A1 (en) * | 2003-11-10 | 2005-07-14 | Angiotech International Ag | Intravascular devices and fibrosis-inducing agents |
US20060141006A1 (en) * | 2003-04-25 | 2006-06-29 | Medtronic Vascular, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007036685A1 (en) * | 2007-08-03 | 2009-02-05 | Innora Gmbh | Improved drug-coated medical devices their manufacture and use |
-
2009
- 2009-03-05 JP JP2010549871A patent/JP2011513000A/en active Pending
- 2009-03-05 US US12/398,407 patent/US20090227980A1/en not_active Abandoned
- 2009-03-05 EP EP09716945.2A patent/EP2265316B1/en not_active Not-in-force
- 2009-03-05 WO PCT/US2009/036121 patent/WO2009111608A1/en active Application Filing
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
US20030114791A1 (en) * | 1990-12-28 | 2003-06-19 | Arthur Rosenthal | Triggered release hydrogel drug delivery system |
US5547472A (en) * | 1994-01-20 | 1996-08-20 | Terumo Kabushiki Kaisha | Catheter with medicament injection pores |
US6123718A (en) * | 1998-11-02 | 2000-09-26 | Polymerex Medical Corp. | Balloon catheter |
US20060141006A1 (en) * | 2003-04-25 | 2006-06-29 | Medtronic Vascular, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
US20050154445A1 (en) * | 2003-11-10 | 2005-07-14 | Angiotech International Ag | Intravascular devices and fibrosis-inducing agents |
Cited By (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10953170B2 (en) | 2003-05-13 | 2021-03-23 | Nuvaira, Inc. | Apparatus for treating asthma using neurotoxin |
US9339618B2 (en) | 2003-05-13 | 2016-05-17 | Holaira, Inc. | Method and apparatus for controlling narrowing of at least one airway |
US8597720B2 (en) | 2007-01-21 | 2013-12-03 | Hemoteq Ag | Medical product for treating stenosis of body passages and for preventing threatening restenosis |
US9192697B2 (en) | 2007-07-03 | 2015-11-24 | Hemoteq Ag | Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis |
US7815687B2 (en) * | 2007-12-18 | 2010-10-19 | Med Institute, Inc. | Method of promoting cell proliferation and ingrowth by injury to the native tissue |
US20090157167A1 (en) * | 2007-12-18 | 2009-06-18 | Bahler Clinton D | Method of promoting cell proliferation and ingrowth by injury to the native tissue |
US8489192B1 (en) | 2008-02-15 | 2013-07-16 | Holaira, Inc. | System and method for bronchial dilation |
US9125643B2 (en) | 2008-02-15 | 2015-09-08 | Holaira, Inc. | System and method for bronchial dilation |
US8731672B2 (en) | 2008-02-15 | 2014-05-20 | Holaira, Inc. | System and method for bronchial dilation |
US11058879B2 (en) | 2008-02-15 | 2021-07-13 | Nuvaira, Inc. | System and method for bronchial dilation |
US10149714B2 (en) | 2008-05-09 | 2018-12-11 | Nuvaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US9668809B2 (en) | 2008-05-09 | 2017-06-06 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8821489B2 (en) | 2008-05-09 | 2014-09-02 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8961507B2 (en) | 2008-05-09 | 2015-02-24 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8961508B2 (en) | 2008-05-09 | 2015-02-24 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US8808280B2 (en) | 2008-05-09 | 2014-08-19 | Holaira, Inc. | Systems, assemblies, and methods for treating a bronchial tree |
US11278648B2 (en) | 2009-07-10 | 2022-03-22 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
US10369256B2 (en) | 2009-07-10 | 2019-08-06 | Boston Scientific Scimed, Inc. | Use of nanocrystals for drug delivery from a balloon |
US10080821B2 (en) | 2009-07-17 | 2018-09-25 | Boston Scientific Scimed, Inc. | Nucleation of drug delivery balloons to provide improved crystal size and density |
US9005195B2 (en) | 2009-10-27 | 2015-04-14 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US9675412B2 (en) | 2009-10-27 | 2017-06-13 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US9017324B2 (en) | 2009-10-27 | 2015-04-28 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US8932289B2 (en) | 2009-10-27 | 2015-01-13 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US8740895B2 (en) | 2009-10-27 | 2014-06-03 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US9931162B2 (en) | 2009-10-27 | 2018-04-03 | Nuvaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US9649153B2 (en) | 2009-10-27 | 2017-05-16 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US8777943B2 (en) | 2009-10-27 | 2014-07-15 | Holaira, Inc. | Delivery devices with coolable energy emitting assemblies |
US8911439B2 (en) | 2009-11-11 | 2014-12-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US11389233B2 (en) | 2009-11-11 | 2022-07-19 | Nuvaira, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
US9649154B2 (en) | 2009-11-11 | 2017-05-16 | Holaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US10610283B2 (en) | 2009-11-11 | 2020-04-07 | Nuvaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US9149328B2 (en) | 2009-11-11 | 2015-10-06 | Holaira, Inc. | Systems, apparatuses, and methods for treating tissue and controlling stenosis |
US11712283B2 (en) | 2009-11-11 | 2023-08-01 | Nuvaira, Inc. | Non-invasive and minimally invasive denervation methods and systems for performing the same |
US10183175B2 (en) | 2010-02-04 | 2019-01-22 | Procept Biorobotics Corporation | Cancer detection and treatment apparatus |
US10016620B2 (en) | 2010-02-04 | 2018-07-10 | Procept Biorobotics Incorporation | Tissue sampling and cancer treatment apparatus |
US10016621B2 (en) * | 2010-02-04 | 2018-07-10 | Procept Biorobotics Corporation | Prostate treatment apparatus |
US10342993B2 (en) | 2010-02-04 | 2019-07-09 | Procept Biorobotics Corporation | Cancer treatment apparatus |
US10369380B2 (en) | 2010-02-04 | 2019-08-06 | Procept Biorobotics Corporation | Tissue sampling, cancer detection and treatment methods |
US20170232228A1 (en) * | 2010-02-04 | 2017-08-17 | Procept Biorobotics Corporation | Prostate treatment apparatus |
US8889211B2 (en) | 2010-09-02 | 2014-11-18 | Boston Scientific Scimed, Inc. | Coating process for drug delivery balloons using heat-induced rewrap memory |
US9937255B2 (en) | 2011-05-18 | 2018-04-10 | Nectero Medical, Inc. | Coated balloons for blood vessel stabilization |
US8669360B2 (en) | 2011-08-05 | 2014-03-11 | Boston Scientific Scimed, Inc. | Methods of converting amorphous drug substance into crystalline form |
US9056152B2 (en) | 2011-08-25 | 2015-06-16 | Boston Scientific Scimed, Inc. | Medical device with crystalline drug coating |
US9398933B2 (en) | 2012-12-27 | 2016-07-26 | Holaira, Inc. | Methods for improving drug efficacy including a combination of drug administration and nerve modulation |
EP3041523A1 (en) * | 2013-09-04 | 2016-07-13 | Danmarks Tekniske Universitet | Enzyme triggered release of bioactive agents by live cells |
WO2015032411A1 (en) | 2013-09-04 | 2015-03-12 | Danmarks Tekniske Universitet | Enzyme triggered release of bioactive agents by live cells |
US11065470B2 (en) | 2014-06-24 | 2021-07-20 | Procept Biorobotics Corporation | Tissue sampling and catheter selection cancer treatment methods |
CN112244925A (en) * | 2020-10-26 | 2021-01-22 | 河北爱能生物科技股份有限公司 | Composite chitosan uterine cavity hemostatic balloon and preparation method thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2009111608A1 (en) | 2009-09-11 |
EP2265316B1 (en) | 2016-01-13 |
EP2265316A1 (en) | 2010-12-29 |
JP2011513000A (en) | 2011-04-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2265316B1 (en) | Triggered drug release | |
EP3238773B1 (en) | Drug coated inflatable balloon having a thermal dependent release layer | |
US5547472A (en) | Catheter with medicament injection pores | |
EP0565604B1 (en) | Catheter for drug delivery system | |
JP4436761B2 (en) | Device with expandable potion for drug release | |
US7364585B2 (en) | Medical devices comprising drug-loaded capsules for localized drug delivery | |
US6409716B1 (en) | Drug delivery | |
US8275455B2 (en) | Medical devices employing conductive polymers for delivery of therapeutic agents | |
JP2010535074A (en) | Improved drug-coated medical products, their manufacture and use | |
JP6472572B2 (en) | Balloon catheter, manufacturing method thereof, and treatment method | |
US11701454B2 (en) | Drug-coated medical devices | |
KR100439156B1 (en) | Covering composition for drug releasing stent and method of preparing same | |
JPH0898893A (en) | Medicine dosing catheter | |
JP6668131B2 (en) | Balloon catheter, manufacturing method and treatment method thereof | |
JP3631777B2 (en) | Drug administration catheter | |
JPWO2018169052A1 (en) | Manufacturing method of balloon catheter | |
JP4456322B2 (en) | Stent | |
JP2021137460A (en) | catheter | |
JPWO2018169054A1 (en) | Balloon catheter, manufacturing method and treatment method thereof | |
CN115212432B (en) | Medicine carrying saccule | |
JP4460332B2 (en) | Stent | |
JP2017169735A (en) | Balloon catheter, and production method and treatment method therefor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: BOSTON SCIENTIFIC SCIMED, INC., MINNESOTA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:KANGAS, STEVE;ATANASOSKA, LILIANA;REEL/FRAME:022704/0814;SIGNING DATES FROM 20090312 TO 20090320 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |