US20090221973A1 - Administering apparatus with a resettable activating block - Google Patents
Administering apparatus with a resettable activating block Download PDFInfo
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- US20090221973A1 US20090221973A1 US12/396,685 US39668509A US2009221973A1 US 20090221973 A1 US20090221973 A1 US 20090221973A1 US 39668509 A US39668509 A US 39668509A US 2009221973 A1 US2009221973 A1 US 2009221973A1
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- United States
- Prior art keywords
- dose
- dosing
- dosage
- indicator sleeve
- setting member
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3125—Details specific display means, e.g. to indicate dose setting
- A61M2005/3126—Specific display means related to dosing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31556—Accuracy improving means
- A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
Abstract
An administering apparatus for administering an injectable substance in doses is provided. The apparatus includes a casing with a reservoir for the substance, a conveying mechanism which acts to deliver a selected dose of the substance from the reservoir, a dosing and activating mechanism which performs a dosing movement and a delivery movement, and which is coupled to the conveying mechanism such that the delivery movement causes the selected dose to be delivered, a dosage indicator sleeve coupled to the dosing and activating mechanism, and a blocking member in a blocking engagement with the dosing and activating mechanism.
Description
- This application is a continuation of U.S. application Ser. No. 11/023,297 filed Dec. 27, 2004, issued as U.S. Pat. No. 7,500,966 on Mar. 10, 2009, which is a continuation of International Patent Application No. PCT/CH2003/000420, filed on Jun. 25, 2003, which claims priority to German Application No. DE 102 29 122 A1, filed on Jun. 28, 2002, the contents of which are incorporated in their entirety by reference herein.
- The present invention relates to devices and methods for delivering or administering substances and, more particularly, to an administering apparatus for administering an injectable substance or product in selected amounts or doses. The administering apparatus can, in particular, be an injection apparatus, for example an injection pen, such as may be used in many different therapies, for example in diabetes therapy or in administering growth hormone.
- Administering apparatus, for example, injection pens, which allow a product or substance dosage to be administered to be selected typically comprise a so-called dosing mechanism which protrudes from a casing opening of the administering apparatus. The dosing mechanism may be button-like, generally similar to the activating button of a ballpoint pen. In order to prepare for the delivery or administration of a substance, the product dosage may be selected by rotating the dosing button relative to the casing. The rotational dosing movement pre-sets a conveying means. For administering, the dosing button is then pressed, from its dosage selection position, a little way into the casing, as far as a front end position. This activates the pre-set conveying means. The conveying means acts on the product or substance contained in a reservoir of the administering apparatus and conveys the selected product dosage, i.e., the product dosage is delivered from the reservoir. In the front end position, the dosing mechanism is blocked against a reverse movement. After the blocking engagement is released, the dosing button is automatically moved back to the dosage selection position and the administering apparatus is ready to administer another dose and, as applicable in some devices, also to select the dosage anew.
- Administering apparatus of the type cited above are known, for example, from WO 99/03522 and EP 0 897 728 A1. In the this type of device, however, in order to increase dosing reliability, the reverse movement of the dosing button back to the dosage selection position is only possible if, in the front end position of the dosing button, a dosage indicator of the administering apparatus has been reset to “zero”. In these apparatus, the dosage is indicated mechanically with the aid of a dosage indicator sleeve. During the dosing movement of the dosing button, the dosage indicator sleeve is also moved relative to the casing. The position of the dosage indicator sleeve relative to the casing is used to indicate the selected product dosage. In the administering apparatus of EP 0 897 728 A1, two dosage indicator sleeve are required for indicating the selected product dosage, namely, one dosage indicator sleeve for indicating individual dosage units and another dosage indicator sleeve for indicating the dosage units in increments of ten.
- In order to reset the dosing button after the product dosage has been administered, the administering apparatus of WO 99/03522 requires two hand operations to be performed: one in order to move the dosage indicator sleeve back to its zero-dosage position and, two, to release a blocking engagement which can only be released in the zero-dosage position of the dosage indicator sleeve. In the administering apparatus of EP 0 897 728 A1, the dosing button is automatically moved back or reset after the two dosage indicator sleeves have been moved back to their zero-dosage position. For the dosing button to be automatically reset by resetting the dosage indicator alone, the dosage indicator sleeve of the two dosage indicator sleeves, which indicate the dosage in increments of ten (the decimal dosage indicator sleeve), is provided with an axial groove. This decimal dosage indicator sleeve surrounds a blocking member which comprises a spring-elastic tongue which is pressed radially inwards by the decimal dosage indicator sleeve into a blocking engagement in which the spring-elastic tongue blocks the resetting movement of the dosing button. If, however, the decimal dosage indicator sleeve is moved to the zero-dosage position, then its axial groove overlaps the spring tongue of the blocking member and the spring tongue can pre-latch radially outwards into the axial groove of the decimal dosage indicator sleeve due to its inherent elasticity force. This pre-latching releases the blocking engagement and the dosing button is automatically moved back to its dosage selection position, driven by the spring force. This resetting mechanism may be susceptible to faults.
- It is an object of the invention to provide a resetting mechanism for resetting a dosing button—or more generally, a dosing and activating means—of an administering apparatus, the resetting mechanism being simple and not susceptible to faults, i.e., accurate and durable or robust.
- In one embodiment, the present invention comprises an administering apparatus for administering a substance in selected doses, wherein the apparatus includes a casing with a reservoir for the substance, a conveying mechanism which acts on the substance to deliver a selected dose of the substance from the reservoir, a dosing and activating mechanism which performs a dosing movement for selecting a dose in a dose selection position and a delivery movement in an activating direction as far as a front end position for delivering the selected dose, and which is coupled to the conveying mechanism such that the delivery movement causes the selected dose to be delivered, a dosage indicator sleeve coupled to the dosing and activating mechanism such that the dosage indicator sleeve is moved relative to the casing by the dosing movement of the dosing and activating mechanism to indicate the selected dose, and a blocking member movable into a blocking engagement with the dosing and activating mechanism in the front end position to prevent the dosing and activating mechanism from moving counter to the activating direction, wherein the blocking member can be moved out of the blocking engagement against an elasticity force and wherein a reset cam protrudes from the dosage indicator sleeve, via which the dosage indicator sleeve moves the blocking member out of the blocking engagement when the dosage indicator sleeve is moved to a zero-dosage position relative to the casing.
- In one embodiment, the present invention relates to an administering apparatus or device for administering an injectable product in doses comprising a casing with a reservoir for the product, a conveying means, a dosing and activating means, at least one dosage indicator sleeve and at least one blocking member for blocking or locking the dosing and activating means after the product has been delivered.
- The conveying means serves to deliver a previously selected product dosage from the reservoir and correspondingly acts on the product situated in the reservoir. In principle, the conveying means can be formed by any type of pump. In some preferred embodiments, however, a piston arranged in the reservoir and a piston rod form the conveying means. The piston and the piston rod can be moved in an advancing direction to deliver the selected product dosage through the outlet of the reservoir by advancing the piston towards the outlet. The piston and the piston rod can be fixedly connected to each other, but in some preferred embodiments the piston rod contacts or presses loosely against the rear side of the piston and, during the dosage selection procedure, exhibits a slight distance from the piston.
- In some embodiments, the dosing and activating means comprises a dosing and activating button and a transfer means which is coupled to the dosing and activating button on the input side with respect to selecting the dosage and activating, and on the output side forms the coupling with the conveying means. The dosing and activating button and the transfer means can be formed in one piece. Forming them in multiple pieces is preferred in some embodiments, wherein the multiple pieces may be connected rigidly to each other with respect to the dosing movement.
- In some embodiments, the product dosage to be administered is selected using the dosing and activating means and delivered by activating the dosing and activating button. Correspondingly, the dosing and activating means can perform a dosing movement relative to the casing for selecting the product dosage in a dosage selection position, and can perform a delivery movement from the dosage selection position in an activating direction as far as a front end position, for delivering the selected product dosage. In some embodiments, the activating direction is the same as the advancing direction of the piston rod, though this is not required. The dosing and activating means is coupled to the conveying means such that delivery movement of the dosing and activating means causes the selected product dosage to be delivered by the conveying means. In one preferred embodiment of the conveying means, in which a displacing piston and a piston rod completely or partially form the conveying means, the dosing and activating means is coupled to the piston rod, for example by threaded engagement, directly or via a transfer element. Selecting a dosage is no longer possible in the front end position, either because the dosing and activating means is no longer accessible for the user in a suitable way for selecting the dosage, because it is decoupled from the conveying means in the front end position, or because it is no longer accessible and is decoupled.
- In some embodiments, the dosage indicator sleeve is coupled to the dosing and activating means such that it is moved relative to the casing by the dosing movement of the dosing and activating means to indicate the selected product dosage. In some embodiments, a pointer indicates the selected product dosage on a dosage scale. In some embodiments, the dosage indicator sleeve is provided with the dosage scale, while the pointer is formed by the casing. In principle, however, the reverse arrangement is also conceivable.
- In some embodiments, in order to block the dosing and activating means the blocking member is in a blocking engagement with the dosing and activating means in the latter's front end position, to prevent a resetting movement of the dosing and activating means, i.e., a movement by the dosing and activating means from the front end position counter to the activating direction. In some embodiments, the blocking engagement is configured such that the resetting movement can only be performed when the dosage indicator sleeve assumes the zero-dosage position, i.e., when it assumes, of its positions relative to the casing, the position corresponding to a zero-dosage. In some preferred embodiments, the blocking engagement is formed between the blocking member and the dosing and activating button directly. However, the blocking engagement can also be formed between the blocking member and the transfer means which couples the dosing and activating button to the conveying means.
- In accordance with the present invention, in some embodiments, the blocking member can be moved out of the blocking engagement against an elasticity force, which conversely means that the elasticity force causes the blocking member to move into the blocking engagement. A cam protrudes from the dosage indicator sleeve, via which the dosage indicator sleeve presses the blocking member out of the blocking engagement when the dosage indicator sleeve is moved to the zero-dosage position. Since the blocking engagement is released by the cam of the dosage indicator sleeve, thus enabling the dosing and activating means to be automatically reset, this cam may be referred to in the following as a reset cam.
- Releasing the blocking engagement by means of the reset cam is advantageous with regard to the inevitable production tolerances in the manufacture of the parts of administering apparatus, since the demands on the precision of positioning and forming the reset cam are significantly lower than for a groove into which the blocking member is to pre-latch, as in the administering apparatus of EP 0 897 728 A1. The present invention has the additional advantage that in the zero-dosage position of the dosage indicator sleeve, the positive lock provided by the reset cam prevents the blocking member from persisting in the blocking engagement. The device and method of the present invention is, therefore, not reliant on elasticity forces for releasing.
- In some embodiments, the reset cam extends only far enough in the direction or directions in which the dosage indicator sleeve can be moved so that the blocking member is definitely free from the reset cam when the dosage indicator sleeve assumes the nearest settable dosage position to the zero-dosage position, relative to the casing. In some embodiments, the dosage indicator sleeve is preferably secured against moving from larger dosage positions beyond the zero-dosage position.
- In some embodiments, the dosage indicator sleeve and the blocking member preferably surround each other, i.e., at least one of said two parts is sleeve-shaped or comprises a sleeve portion. In one preferred embodiment, the dosage indicator sleeve surrounds the blocking member. In this embodiment, the reset cam preferably protrudes from an inner surface area of the dosage indicator sleeve towards the blocking member.
- In some embodiments, the reset cam may be continuously widened on at least one side via which it leads onto the blocking member when the dosage indicator sleeve moves to the zero-dosage position, as far as the surface area of the dosage indicator sleeve from which it protrudes, in order that the blocking member and the reset cam slide off of each other in the manner of oblique planes during this movement. In one preferred embodiment, in which the movement of the dosage indicator sleeve is or comprises a rotational movement, the reset cam is widened in the circumferential direction towards the surface area. If the movement of the dosage indicator sleeve is a superimposed movement consisting of a rotational movement and a translational movement, the reset cam can advantageously also be widened towards its foot region in the translational direction towards the side via which it leads onto the blocking member in the direction of the translational movement.
- In a preferred embodiment, the blocking member forms a counter reset cam, against which the reset cam presses in the zero-dosage position of the dosage indicator sleeve, in order to release the blocking engagement. The counter reset cam may also be tapered towards its free end facing the reset cam, on the side via first comes into contact with the reset cam when the dosage indicator sleeve moves to the zero-dosage position, i.e., the counter reset cam may also be gradually widened towards its foot region.
- As already mentioned, the dosage indicator sleeve can form the dosage scale or the pointer of the dosage indicator; in some preferred embodiments, it forms the dosage scale. The dosage scale can be formed on an upper surface area of the dosage indicator sleeve such that it runs back into itself. When selecting the dosage in such an embodiment, however, the dosage indicator sleeve may only be able to perform a single revolution, as a result of which the indicator fineness would suffer, or the dosage which could be selected would be very limited. A solution comprising multiple dosage indicator sleeves would be conceivable, but would increase the complexity of the mechanism. In order to avoid these disadvantages, in some embodiments, the dosage scale can encircle a longitudinal axis of the dosage indicator sleeve in a spiral. Essentially the same advantage would also be achieved if a dosage scale encircling in a spiral on the casing were provided and the dosage indicator sleeve formed the pointer for said dosage scale. Using a dosage scale encircling in a spiral, it is possible to select a large dosage with sufficient dosing fineness and good legibility of the dosage scale. If the dosage scale is spiral, the movement of the dosage indicator sleeve should correspondingly be a movement composed of rotation and translation. In one preferred embodiment, the dosage indicator sleeve is coupled to the casing via a threaded engagement, in order to obtain such a superimposed, well-defined movement.
- In accordance with a preferred embodiment of the present invention, the dosing and activating button is either spring-elastic, or supported spring-elastically on the transfer means, in the activating direction. The same elasticity force against which the dosing and activating button spring-deflects in the activating direction pushes counter to the activating direction, against a stopper. The spring deflection is advantageous for the delivery movement, since the user of the administering apparatus cannot simply press against a fixed stopper when activating the dosing and activating means. Rather, in the front end position of the dosing and activating means, the dosing and activating button spring-elastically gives a little way further in the activating direction under the pressure from the user. In order to spring-deflect the dosing and activating button relative to the transfer means in this way, the blocking member preferably forms a stopper in the blocking engagement. If the blocking member is inserted into a cavity formed on the dosing and activating button in order to establish the blocking engagement, such a cavity can exhibit a greater extension in the activating direction than would be possible with a rigid stopper of the dosing and activating button, due to the spring-deflection movement.
- As already mentioned, in some embodiments, the blocking member is moved into a cavity formed on the dosing and activating means, preferably on the dosing and activating button, in order to establish the blocking engagement. In one preferred embodiment, a groove which encircles on an upper surface area of the dosing and activating means forms the cavity. Equally, however, the cavity in its entirety can also be formed by a plurality of separate cavities which are formed on such an upper surface area spaced from each other, in some preferred embodiments, circumferentially. In principle, a single cavity at a single point on the dosing and activating means would alone be sufficient, but would be disadvantageous with respect to selecting the dosage.
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FIG. 1 depicts a product delivery device in accordance with the present invention in an initial state, before a dosage is selected for the first time; -
FIG. 2 depicts the product delivery device ofFIG. 1 in an end state, in which a piston rod of the device assumes a foremost position and is in engagement with a dosing member; -
FIG. 3 depicts the product delivery device ofFIG. 1 in a state in which the piston rod and the dosing member are out of engagement and the piston rod has been reset to a rearmost initial position; -
FIG. 4 is a cross-section along line A-A inFIG. 2 ; -
FIG. 5 is a cross-section along line B-B inFIG. 3 ; -
FIG. 6 depicts the piston rod, the dosing member and gear members of a cam gear in a three-dimensional section, wherein the piston rod and the dosing member are in engagement; -
FIG. 7 depicts the piston rod, the dosing member and the gear members in a three-dimensional section, wherein the piston rod and the dosing member are out of engagement; -
FIG. 8 depicts components of an embodiment of the device in accordance with the present invention in a three-dimensional representation; -
FIG. 9 depicts a dosage indicator sleeve and components in accordance with the present invention co-operating with the dosage indicator sleeve in a three-dimensional representation; and -
FIG. 10 , includingFIGS. 10 a-d, depicts an embodiments of the dosage indicator sleeve in accordance with the present invention, in multiple representations. - The figures, including
FIGS. 1-3 , show one embodiment of a device for delivering a selected dosage of a liquid product or substance. The product can in particular be a medicine or a therapeutic substance, for example insulin. - In one embodiment, the device comprises a casing in two parts, comprising a first, front casing portion 1 and a second,
rear casing portion 2, which are each formed as sleeve parts. The twocasing portions 1, 2 are screwed together. The front casing portion 1 contains a reservoir R filled with the product. The reservoir R is formed by an exchangeable container, in the example embodiment by a hollow-cylindrical ampoule. The container is inserted from the rear into the front casing portion 1 until it abuts a stopper formed by the front casing portion 1. At its front end, the container comprises an outlet A which is sterilely sealed by a septum. In order to be able to deliver the product from the reservoir R formed in this way, a cannula is introduced through the septum into the outlet A. At its rear end, the reservoir R is sealed tight by a piston K. Product is displaced from the reservoir R, i.e. delivered through the outlet A, by advancing the piston K in an advancing direction V, towards the outlet A, along a longitudinal axis L. - The piston K is moved in the advancing direction V by means of a
piston rod 4 which is linearly guided along the longitudinal axis L, i.e. axially, by the casing. Thepiston rod 4 is operably coupled to a dosing and activating means which, in one embodiment, comprises adosing sleeve 7, a sleeve-shaped dosing and activatingbutton 8 and a sleeve-shapedtransfer element 10. A split dosing member comprising, in one embodiment, two separate identical parts ormembers parts first dosing member 11 and thesecond dosing member 12. Thefirst dosing member 11 and thesecond dosing member 12 are each in a threaded engagement about the longitudinal axis L, which is simultaneously also the longitudinal axis of thepiston rod 4, with thepiston rod 4 which is formed as a threaded rod. Thefirst dosing member 11 and thesecond dosing member 12 are connected, secured against shifting axially and secured against rotating with respect to rotations about the longitudinal axis L, to thetransfer element 10. However, both thefirst dosing member 11 and thesecond dosing member 12 can be moved relative to thetransfer element 10 and in particular relative to thepiston rod 4 in a transverse direction with respect to the longitudinal axis L. In order for them to be able to move in the transverse direction, thetransfer element 10 linearly guides thefirst dosing member 11 and thesecond dosing member 12 by forming a guiding shaft pointing generally transversely with respect to the longitudinal axis L for each of the twodosing members FIGS. 6 and 7 , each of the guiding shafts comprises aside wall 10 a pointing in the advancing direction V and a side wall 10 b pointing counter to the advancing direction V. Theside walls 10 a, 10 b each form a linear transverse guiding rail, pointing transversely with respect to the longitudinal axis, for one of thedosing members dosing members dosing members dosing members - With respect to the form, function and co-operation of the components which co-operate for dosing and delivering the product, reference should additionally be made to
FIG. 8 . - In one embodiment, the dosing and activating
button 8 is detachably connected to thetransfer element 10. The dosing and activatingbutton 8 is composed of multiple individual parts, namely anouter sleeve part 8 a protruding out of therear casing portion 2, an insertedinner sleeve part 8 b, an end button 8 c which is inserted from the rear into theouter sleeve part 8 a and locked, and aspring 8 d which is axially tensed between the end button 8 c and theinner sleeve part 8 b. Theinner sleeve part 8 b serves to fasten the dosing and activatingbutton 8 to thetransfer element 10 and may, therefore, be referred to in the following as thefastening part 8 b. Theouter sleeve part 8 a is accessible for the user for activating the administering apparatus and may, therefore, be referred to in the following as the activatingpart 8 a. The activatingpart 8 a is connected, secured against shifting, to the end button 8 c and supported on thefastening part 8 b via the pressure-tensedspring 8 d. The activatingpart 8 a can be moved in and counter to the advancing direction V relative to thefastening part 8 b and therefore also relative to thetransfer element 10. Thespring 8 d presses the activatingpart 8 a counter to the advancing direction V until it abuts thefastening part 8 b, such that it assumes the rear stopper position, shown inFIGS. 1 to 3 , relative to thefastening part 8 b. Correspondingly, it can be moved relative to thefastening part 8 b and thetransfer element 10 in the advancing direction V by pressing against the elasticity force of thespring 8 d. This ability to move in the advancing direction V is advantageous for activating the dosing and activating means, which, due to this feature, can spring-deflect into itself. - In the following, the
components 8 a to 8 d may be referred to in their entirety as the dosing and activatingbutton 8. - An
encircling groove 9 is formed on the outer surface area of the dosing and activatingbutton 8, in the exemplary embodiment on the outer surface area of theouter sleeve part 8 a, in a portion surrounding thetransfer element 10. Thegroove 9 co-operates with a blockingmember 45 which is formed annularly, surrounds the outer surface area of the dosing and activatingbutton 8, and is tensed radially inwardly against the outer surface area of the dosing and activatingbutton 8 by means of a spring element 49. - The
dosing sleeve 7 is attached to the rear end of therear casing portion 2 and can be rotated about the longitudinal axis L, relative to therear casing portion 2. At its rear end, thedosing sleeve 7 forms a collar which protrudes radially inwardly and forms teeth 7 a (FIG. 9 ) uniformly distributed over its inner circumference. On an outer surface area opposite the teeth 7 a, the dosing and activatingbutton 8 forms linear, axial guiding grooves at a corresponding pitch, in each of which one of the teeth 7 a is axially and linearly guided. In this way, thedosing sleeve 7 and the dosing and activatingbutton 8 are secured against rotating about the longitudinal axis L, but are connected such that they can move axially relative to each other. - A
piston rod holder 6 forms an axial linear guide for thepiston rod 4. Thepiston rod holder 6 is connected to therear casing portion 2 such that it cannot move, in particular thepiston rod holder 6 can neither be axially moved relative to therear casing portion 2 or rotated about the longitudinal axis L. Thepiston rod holder 6 and thepiston rod 4 can only move axially relative to each other. In this way, thepiston rod 4 is axially and linearly guided relative to therear casing portion 2. - Between a rear end of the
piston rod holder 6 and a collar, protruding radially inward, of amechanism holder 5, a slidingpiece 15 is radially mounted over thefirst dosing member 11 and another slidingpiece 16 is radially mounted over thesecond dosing member 12, each secured against shifting axially, but radially and linearly guided and, in this sense, able to move radially. The slidingpieces first dosing member 11 andsecond dosing member 12. The slidingpieces mechanism holder 5 is connected immovably to therear casing portion 2, so it cannot move axially relative to therear casing portion 2, to which end the three-quarter rib 56 serves as a stopper, and cannot rotate about the longitudinal axis L. - The sliding
pieces dosing members gear input member 20 formed as a sliding sleeve and referred to in the following using this designation. The slidingsleeve 20 forms another cam member and the two slidingpieces sleeve 20 can be axially moved relative to thefirst dosing member 11 andsecond dosing member 12, the two slidingpieces rear casing portion 2. Furthermore, it can be rotated about the longitudinal axis L relative to therear casing portion 2. A circular cylindrical inner surface area of themechanism holder 5 forms a rotational sliding bearing and an axial linear guide for the slidingsleeve 20. -
FIGS. 4 and 5 show the cam gear with the split dosing member and thepiston rod 4, each in the same cross-section, relative to the dosing member, but in different gear states. The same gear states are shown inFIGS. 6 and 7 , each in a three-dimensional section. Regarding the mode of operation of the cam gear, reference should additionally also be made toFIGS. 4 to 7 . - The sliding
pieces sleeve 20 forms a corresponding counter cone on its inner surface facing the conical areas of the slidingpieces pieces sleeve 20 are generally parallel to each other, forming a conical gap which is uniformly wide over the entire conical areas. - As can be perceived in
FIGS. 4 and 5 , the slidingsleeve 20 forms two guidingrails 21 for the slidingpiece 15 and two guidingrails 22 for the slidingpiece 16. The slidingpieces sleeve 20, diametrically opposed to each other on both sides of the longitudinal axis L. The same applies to the guiding rails 22. The guiding rails 21, 22 extend in the axial direction and each exhibit a substantially constant inclination with respect to the longitudinal axis L, i.e., the guiding rails 21, 22 are linear. The guiding rails 21 are generally parallel to each other, as are the guiding rails 22. The guiding rails 21, 22, formed on the left-hand side and right-hand side of the slidingsleeve 20 in the cross-section inFIGS. 4 and 5 , run sagittally towards each other in the advancing direction V—as seen in the longitudinal section in FIG. 1—at an acute angle bisected by a straight line parallel to the longitudinal axis L. When the slidingsleeve 20 moves axially relative to the slidingpieces pieces engagement rails 18 on the guiding rails 21, 22, such that the slidingpieces - The
first dosing member 11 is accommodated, axially and linearly guided, in the slidingpiece 15. Thesecond dosing member 12 is correspondingly accommodated, axially and linearly guided, in its slidingpiece 16. On their mutually facing lower sides, on the left-hand and right-hand side in the cross-section, the slidingpieces piece 15 grips behind thefirst dosing member 11 with its twostays 17, and the slidingpiece 16 grips behind thesecond dosing member 12 with its two stays 17. If the two slidingpieces stays 17 gripping behind thedosing members dosing members piston rod 4. When the slidingpieces pieces dosing members piston rod 4. As already mentioned, thedosing members piece dosing members stays 17 grip behind. - The threaded engagement between the
piston rod 4 and the split dosing member which exists in the state inFIG. 1 is released by thecasing portions 1, 2 moving axially relative to each other. This relative movement occurs when thecasing portions 1, 2 are screwed apart. When thecasing portions 1, 2 are screwed apart, the casing formed jointly by thecasing portions 1, 2 is initially lengthened, which corresponds to thecasing portions 1, 2 moving axially relative to each other. The relative movement between thecasing portions 1, 2, for example for exchanging the reservoir R, is thus used to release the engagement between thepiston rod 4 and the split dosing member and the block against thepiston rod 4 and the dosing and activating means axial shifting obtained by this engagement. - In order to be able to use the
casing portions 1, 2 moving axially relative to each other to release the engagement, the slidingsleeve 20 is connected to the front casing portion 1 in such a way that it is slaved in its axial movement relative to the rear casing portion, while the slidingpieces rear casing portion 2. Mounting the slidingpieces mechanism holder 5 and thepiston rod holder 6 ensures, as mentioned, that the slidingpieces sleeve 20 on the front casing portion 1 forms areservoir holding spring 37 which is axially pressure-tensed between thepiston rod holder 6 and areservoir holder 30 when the twocasing portions 1, 2 are completely screwed together. To this end, thereservoir holding spring 37 is tensed between thepiston rod holder 6 and thereservoir holder 30. Thereservoir holding spring 37 presses thereservoir holder 30 against the rear edge of the container which forms the reservoir R. Thereservoir holding spring 37 presses the container against a stopper area formed in the front casing portion 1. Arranging such areservoir holding spring 37 is common in order to equalise length tolerances of the container, thecasing portions 1, 2 and the components on which the container is supported in the longitudinal direction. - A slaving means 25 is fastened, secured against shifting and secured against rotating, to the
reservoir holder 30. The slaving means 25 forms a transfer member between thereservoir holder 30 and the slidingsleeve 20, when thereservoir holder 30 follows an axial movement of the front casing portion 1 due to the spring force of thereservoir holding spring 37. The slidingsleeve 20 and the slaving means 25 grip behind each other such that the slidingsleeve 20 is slaved by the slaving means 25 during the axial movement. In the exemplary embodiment, atolerance equalisation spring 38 is axially tensed between the slidingsleeve 20 and the slaving means 25. In principle, however, the slidingsleeve 20 and the slaving means 25 could also be rigidly connected to each other with respect to the axial direction. In any event, a rotational movement about the longitudinal axis L is possible between the slidingsleeve 20 and the slaving means 25. In this respect, the rotational joint between the dosing and activating means and therear casing portion 2 is formed between the slidingsleeve 20 and the slaving means 25. - How the
gear components piston rod holder 6 can be perceived inFIG. 8 . The mutually facingcollars 31, 61 of thereservoir holder 30 andpiston rod holder 6 in particular can for instance be recognized, between which thereservoir holding spring 37 is tensed. Thereservoir holder 30 comprises a circular cylindrical front sleeve part including acollar 31.Multiple shoes 32 project backwards from the sleeve part. A lockingcam 34 which protrudes radially outwards is formed at the rear end of each of theshoes 32. Furthermore, each of theshoes 32 comprises lateral guides 33. Thereservoir holder 30 together with itsshoes 32 can be inserted between a radially outer and middle sleeve part of thepiston rod holder 6. To this end, a sleeve base of thepiston rod holder 6 comprises cavities corresponding to theshoes 32. Thepiston rod holder 6 and thereservoir holder 30 are connected to each other, secured against rotating, via theshoes 32 and the cavities. From the rear side, the slaving means 25 is pushed onto thereservoir holder 30 via the middle sleeve part of thepiston rod holder 6.Tongues 27 project from a rear sleeve part of the slaving means 25, corresponding in number and arrangement to theshoes 32. Each one of thetongues 27 is pushed onto one of theshoes 32 and locked by means of the lockingcams 34, wherein the lockingcams 34 lock intocavities 28 formed correspondingly on thetongues 27. The connection between the slaving means 25 and thereservoir holder 30 can be regarded as substantially completely rigid. - The sliding
sleeve 20 comprises a rear sleeve part and a plurality of elastically bendingtongues 23, which project from the sleeve part and protrude toward the slaving means 25 in the advancing directionV. Slaving cams 24 are formed at the front ends of thetongues 23 and project radially outward from thetongues 23. When the slaving means 25 moves axially, the slidingsleeve 20 is slaved or driven by an engagement which exists when the slavingcams 24 are connected to aslaving collar 26 which protrudes radially inward at the rear end of the slaving means 25 and which theslaving cams 24 grip behind when connected. The engagement simultaneously enables relative rotational movements about the longitudinal axis L. - Furthermore, it can also be recognized in
FIG. 8 how themechanism holder 5 and thepiston rod holder 6 are connected, secured against shifting and secured against rotating.Elastically bending tongues 63, comprising lockingcams 64 protruding radially outward, project backwards from the sleeve part of thepiston rod holder 6. Via thelocking cams 64, thepiston rod holder 6 locks in correspondingcavities 52 of themechanism holder 5. Furthermore, a block against rotating between themechanism holder 5 and thepiston rod holder 6 is obtained by engaging a guidingprotrusion 62, which axially projects from thepiston rod holder 6, with a guidingcavity 51 of themechanism holder 5. Themechanism holder 5 and thepiston rod holder 6 are connected to each other, secured against shifting and secured against rotating, via the locking connection of the lockingcam 64 and the guide of the guidingprotrusion 62. Themechanism holder 5 is connected to therear casing portion 2, secured against shifting and secured against rotating, such that the same also applies to thepiston rod holder 6. - A restoring
spring 36 is axially tensed between thepiston rod holder 6 and thetransfer element 10 of the dosing and activating means. The restoringspring 36 serves to restore or reset the dosing and activating means, the split dosing member and thepiston rod 4 after the product has been delivered. - In one embodiment, the device in accordance with the present invention further comprises a
dosage indicator sleeve 40, which is provided on its outer surface area with adosage scale 41. Thedosage indicator sleeve 40 is shown in a three-dimensional view from the side in each ofFIGS. 8 and 9 , and in two longitudinal sections, a front view and a rear view inFIG. 10 . It is in threaded engagement with themechanism holder 5. The threaded engagement exists between anouter thread 53 in a rear portion of themechanism holder 5 and aninner thread 42 of thedosage indicator sleeve 40. The threaded axis of the twothreads dosage scale 41 is formed by dosage values arranged, encircling in a spiral, on the outer surface area of thedosage indicator sleeve 40. In the exemplary embodiment, numbers corresponding to the dosage units which can be selected form the dosage values. Thedosage indicator sleeve 40 is connected to thedosing sleeve 7 such that it can be axially and linearly shifted, but is secured against rotating with respect to the longitudinal axis L. For this purpose, the rear end of thedosage indicator sleeve 40 comprises a plurality of radially projecting guidingcams 43 which protrude into and are axially and linearly guided in corresponding guiding grooves 7 b (FIG. 9 ) on the inner surface area of thedosing sleeve 7. Due to this engagement, thedosage indicator sleeve 40 is also rotated about the longitudinal axis L when thedosing sleeve 7 is rotated. Due to the threaded engagement with themechanism holder 5, thedosage indicator sleeve 40 is thus screwed backwards, counter to the advancing direction V, relative to themechanism holder 5 and, therefore, also relative to therear casing portion 2, when the dosage is selected by rotating thedosing sleeve 7. - The portion of the
dosage indicator sleeve 40 which forms theinner thread 42 and thedosage scale 41 protrudes or extends into an annular gap which remains between therear casing portion 2 and themechanism holder 5. In the radially outer portion opposing thedosage scale 41, therear casing portion 2 comprises a window 3 through which thedosage scale 41 can be read. The pitch of theinner thread 42 corresponds to the pitch of thespiral dosage scale 41. - The blocking
member 45 already mentioned, which due to its form may be referred to in the following as the blocking ring, is arranged radially inwards from a longitudinal portion of thedosage indicator sleeve 40, which protrudes backwards beyond themechanism holder 5. The blockingring 45 is mounted, secured against rotating and secured against shifting axially, in a sleeve part of a blockingring holder 47. The blockingring holder 47 is fastened, secured against rotating and shifting, to themechanism holder 5, via a guidingarea 54 of themechanism holder 5 and a locking connection formed between a locking cam 55 of themechanism holder 5 and acavity 48 of the blocking ring holder 47 (FIG. 8 ). - The blocking
ring 45 forms acounter reset cam 46 which protrudes radially outwards from the outer surface area of the blockingring 45 towards thedosage indicator sleeve 40. Areset cam 44 projects radially inwards from the facing inner surface area of the dosage indicator sleeve 40 (FIG. 10 ). Thereset cam 44 is formed in a rotational angular position with respect to thedosage scale 41, such that it is in radial alignment with the counter resetcam 46 and presses radially against thecam 46 precisely when thedosage indicator sleeve 40 assumes a zero-dosage position relative to therear casing portion 2, in which the dosage value corresponding to the zero-dosage is indicated in the window 3. If thedosage indicator sleeve 40 assumes a position with respect to themechanism holder 5 and therear casing portion 2 which does not correspond to the zero-dosage, then the counter resetcam 46 is free from thereset cam 44, i.e., a radially slight distance remains between the counter resetcam 46 and the facing inner surface area of thedosage indicator sleeve 40. - The blocking
ring 45 can be moved linearly relative to the blockingring holder 47, radially with respect to the longitudinal axis L. Diametrically opposite the counter resetcam 46 with respect to the longitudinal axis L, the spring element 49 is arranged between the blockingring 45 and the blockingring holder 47 and presses the blockingring 45 against the outer surface area of the dosing and activatingbutton 8. The spring element 49 acts as a pressure spring. - The functionality and method of operation of the device in accordance with the present invention is described below with reference to
FIGS. 1 to 3 , in each of which the device is shown in a different state. Reference should also additionally be made to the other figures. - In
FIG. 1 , the device assumes an initial state in which the reservoir R is completely filled with the product and from which the dosage can be selected. Thedosage indicator sleeve 40 assumes its position corresponding to the zero-dosage, i.e., the dosage value corresponding to the zero-dosage can be read through the window 3. The dosing and activating means (comprising, in one embodiment, thedosing sleeve 7, dosing and activatingbutton 8 and transfer element 10), together with thepiston rod 4, assumes its rearmost position, in which the dosage is selected. In this dosage selection position, a slight axial distance H1 remains between thepiston rod 4 and the piston K. An equally large, slight axial distance H2 remains between two stopper areas which face each other axially, one of which is formed by thepiston rod holder 6 and the other of which is formed by thetransfer element 10 and which define a front end position for thetransfer element 10 and thepiston rod 4. The slight axial distance H2 between this pair of stopper areas is the maximum stroke of thepiston rod 4. Selecting the dosage reduces the slight axial distance H1 between the piston K and thepiston rod 4. If, within the context of the delivery movement, thepiston rod 4 is then moved in the advancing direction V by the always equally long stroke H2 as far as its front end position, then the reduction in the slight distance H1 between thepiston rod 4 and the piston K while selecting the dosage corresponds to the product dosage delivered. - The split dosing member (comprising, in one embodiment,
dosing members 11, 12) is coupled to thedosage indicator sleeve 40 via the dosing and activating means, such that the axial distance H1 between the piston K and thepiston rod 4 is at a maximum, i.e., H1=H2, when thedosage indicator sleeve 40 assumes its zero-dosage position. - To select the dosage, the
dosing sleeve 7 is rotated about the longitudinal axis L relative to therear casing portion 2, wherein the dosing and activatingbutton 8 is also rotated due to its engagement, secured against rotating, with thedosing sleeve 7. Due to these connections, secured against rotating, thetransfer element 10 and therefore also the split dosing member are also necessarily rotated together. Since thepiston rod 4 is axially and linearly guided by thepiston rod holder 6, the rotational movement of the split dosing member causes a dosing movement of thepiston rod 4 directed in the advancing direction, via the threaded engagement. This shortens the slight distance H1 between thepiston rod 4 and the piston K by a length corresponding to the selected product dosage; it does not alter the slight distance H2. - Due to its engagement, secured against rotating, the
dosage indicator sleeve 40 is slaved or driven correspondingly by thedosing sleeve 7 during the rotational dosing movement and rotated about the longitudinal axis L relative to themechanism holder 5. Due to the threaded engagement between themechanism holder 5 and thedosage indicator sleeve 40, an axial movement counter to the advancing direction V is superimposed on the rotational movement of thedosage indicator sleeve 40. As an aside, it may be mentioned that the pitch of the engagedthreads dosage indicator sleeve 40 andmechanism holder 5 is greater than the pitch of the engaged threads of thepiston rod 4 and split dosing member. Correspondingly, the axial path which thedosage indicator sleeve 40 travels per revolution is larger than the axial path by which thepiston rod 4 is moved per revolution of the split dosing member. This benefits the legibility of thedosage scale 41. As soon as thedosage indicator sleeve 40 has been moved, relative to themechanism holder 5, out of its zero-dosage position by at least one dosage unit, the blockingring 45 is free from thereset cam 44. The dosage value which can be read on thedosage scale 41 through the window 3 corresponds to the axial length by which the distance H1 is shortened by the dosing movement. - In order to deliver the selected product dosage through the outlet A of the reservoir R, the dosing and activating
button 8 is pressed in the advancing direction V, into therear casing portion 2, i.e., it is activated. The advancing direction V is therefore also simultaneously the activating direction of the dosing and activatingbutton 8. Activating the dosing and activatingbutton 8 also moves the components which are connected, secured against shifting axially, to the dosing and activatingbutton 8, namely thetransfer element 10, the split dosing member and, due to the threaded engagement also thepiston rod 4, in the advancing direction V by the stroke length H2. During this stroke movement, the piston K is advanced in the advancing direction V by a path length which corresponds to the length by which the slight distance H1 between thepiston rod 4 and the piston K is shortened as compared to the stroke H2 by selecting the dosage. -
FIG. 2 shows the exemplary device in an end state in which, after repeated administering, the maximum product amount which can be delivered from the reservoir R with the aid of the device has been delivered, i.e., the reservoir R has been emptied. The dosing and activatingbutton 8 has been pressed into therear casing portion 2 by the stroke length H2. In this axial position of the dosing and activatingbutton 8, itsgroove 9 is in radial alignment below the blockingring 45. Thegroove 9 is slightly wider in the radial direction than the blockingring 45, in order to still be able to accommodate the blockingring 45 when the dosing and activatingbutton 8 is spring-deflected. For the pressure from the user, required for activating the dosing and activatingbutton 8, spring-deflects the dosing and activatingbutton 8 a little way into itself, in the front end position of thetransfer element 10 and thepiston rod 4, which is regarded as touch-sense pleasant. Since the blockingring 45 is tensed against the outer surface area of the dosing and activatingbutton 8 by the spring element 49, the blockingring 45 is inserted radially into thegroove 9 which is then accessible for it. The larger width of thegroove 9 as compared to the blockingring 45, in combination with the axial spring-deflection of the dosing and activatingbutton 8, increases the reliability that the blockingring 45 will indeed be inserted into thegroove 9 and the dosing and activating means blocked. The blockingring 45 forms an axial stopper for the spring-deflection movement of the dosing and activatingbutton 8. Diametrically opposite the spring element 49, inserting the blockingring 45 moves its counter resetcam 46 radially towards the inner surface area of thedosage indicator sleeve 40. Since the blockingring 45 is connected to themechanism holder 5 such that it cannot move axially in the blockingring holder 47, the dosing and activatingbutton 8 and therefore thepiston rod 4 together cannot be moved back again counter to the advancing direction V, i.e., the blockingring 45 and the dosing and activatingbutton 8 are in a blocking engagement. Thus, in the foremost position of the dosing and activating means, the blocking-engagedblocking ring 45 seated in thegroove 9 forms an axial block for the dosing and activating means, the split dosing member and thepiston rod 4. In this end state, the restoringspring 36 is axially pressure-tensed. The restoringspring 36 is prevented from being relieved by the axial block formed by the blockingring 45. This axial block ensures that the product can only be selected anew from a defined position of thedosage indicator sleeve 40. This defined position is preferably—as in the exemplary embodiment—the zero-dosage position, i.e., the position in which the zero-dosage can be read on thedosage scale 41 through the window 3. - In order to exchange the emptied reservoir R for a new reservoir R, the two
casing portions 1, 2 are screwed apart. Due to the screwing procedure, thecasing portions 1, 2 are moved axially relative to each other. During the movement ofcasing portions 1, 2 which lengthens the casing, the tensedreservoir holding spring 37 presses thereservoir holder 30 relative to thepiston rod holder 6 in the advancing direction V until it abuts a stopper formed by therear casing portion 2. Before the screwing movement is begun, a sufficiently large, slight distance remains axially between a front end of thereservoir holder 30 and the stopper formed by therear casing portion 2, to enable thereservoir holder 30 to move axially relative to thepiston rod holder 6. - As the
reservoir holder 30 moves axially relative to thepiston rod holder 6, it slaves the slaving means 25 and the slidingsleeve 20. Due to the axial movement of the slidingsleeve 20, the two slidingpieces sleeve 20. As they move radially outwards in this way, the slidingpieces mechanism holder 5 and thepiston rod holder 6. Since thestays 17 of the slidingpiece 15 grip behind thefirst dosing member 11 and thestays 17 of the slidingpiece 16 grip behind thesecond dosing member 12, thefirst dosing member 11 and thesecond dosing member 12 are moved radially apart in the same way, and are thus moved out of their threaded engagement with thepiston rod 4. The axial movement which therear casing portion 2 performs relative to the front casing portion 1 in order to release the engagement between thepiston rod 4 and thedosing members dosing members piston rod 4. In the opposite, engaging movement, in which therear casing portion 2 performs an axial movement in the reverse direction relative to the front casing portion 1, thedosing members piston rod 4 by the cam gear formed by slidingsleeve 20 and the slidingpieces casing portions 1, 2 completely screwed together, the disengaging movement and the engaging movement occur in a first portion of the screwing movement. This first portion of the screwing movement is complete when thereservoir holding spring 37 has pressed thereservoir holder 30 against the stopper formed by therear casing portion 2. -
FIG. 3 shows the device in a state in which the threaded engagement between the split dosing member and thepiston rod 4 has been released and thepiston rod 4 can thus be freely shifted axially in thepiston rod holder 6. Therear casing portion 2 has just completed its disengaging movement. In the state shown, thepiston rod 4 has already been reset to its rearmost position. Thepiston rod 4 can thus slide back, guided by thepiston rod holder 6, to the end position shown, for example by gently tilting the entire device. At the rear end of thedosing button 8, a rubber stopper projects inwards in the advancing direction V and gently damps or stops the sliding movement of thepiston rod 4. - As the
casing portions 1, 2 are screwed further apart, the positions assumed by thedosing members pieces sleeve 20 and thereservoir holder 30 relative to therear casing portion 2 are no longer altered. This is ensured by thereservoir holder 30 abutting therear casing portion 2. The twocasing portions 1, 2 can be screwed completely apart and the spent reservoir R exchanged for a new one. After a new reservoir R has been inserted into the front casing portion 1, the twocasing portions 1, 2 are screwed back together. In the final portion of the screwing movement, therear casing portion 2 performs its engaging movement relative to the front casing portion 1, in which thereservoir holder 30 comes into contact with the reservoir R or a reservoir holder and is pressed by the latter axially towards thepiston rod holder 6, against the spring force of thereservoir holding spring 37. As it axially moves, thereservoir holder 30 also presses the slidingsleeve 20, via the slaving means 25, backwards counter to the advancing direction V. This moves the slidingpieces sleeve 20, until the synchronous engagement between thedosing members piston rod 4 is re-established. - Where, in the above, resetting the
piston rod 4 is only described for a completely spent reservoir R, it should be noted that thepiston rod 4 can also be reset in accordance with the invention from any other axial position of thepiston rod 4 in which thepiston rod 4 has been moved out of its rearmost position shown inFIG. 1 by a rotational dosing movement by the split dosing member. - When the dosing and activating
button 8 is pressed into in therear casing portion 2 to its foremost position, as inFIGS. 2 and 3 , there is no longer a block against rotating between thedosing sleeve 7 and the dosing and activatingbutton 8, i.e., thedosing sleeve 7 can be freely rotated about the longitudinal axis L relative to the dosing and activatingbutton 8 andrear casing portion 2. However, the block against rotating between thedosing sleeve 7 and thedosage indicator sleeve 40 still exists. In order to return the dosing and activatingbutton 8 and, therefore, the dosing and activating means and split dosing member together to the dosage selection position, thedosing sleeve 7 is rotated about the longitudinal axis L in a rotational direction which guides thedosage indicator sleeve 40 back to the zero-dosage position. During this rotational movement, thedosage indicator sleeve 40 is rotated relative to themechanism holder 5. As a result of the threaded engagement with themechanism holder 5, thedosage indicator sleeve 40 completes a translational and rotational movement relative to themechanism holder 5 andrear casing portion 2, towards its zero-dosage position. In a final movement portion before reaching the zero-dosage position, the length of which corresponds to a single settable dosage unit, thereset cam 44 of thedosage indicator sleeve 40 radially overlaps with the counter resetcam 46 of the blockingring 45. Thereset cam 44 is tapered in the circumferential direction on the side which presses against the counter resetcam 46 while thedosage indicator sleeve 40 is rotated back. Tapering enables the twocams reset cam 44, which gradually lengthens radially inwards in its tapered region, moves the blockingring 45 radially out of thegroove 9, against the restoring force of the spring element 49. The axial block is thus released, and the restoringspring 36 presses the dosing and activating means, together with thepiston rod 4, back to the initial position shown inFIG. 1 . - The sequence of selecting the dosage, delivering the selected dosage by activating the dosing and activating means, axially blocking with the blocking
ring 45 via thecam 46, rotating thedosage indicator sleeve 40 back to the zero-dosage position and thus releasing the axial block and springing the dosing and activatingmeans 7/8/10 back to the initial position, can be repeated until the reservoir R has been emptied. Thecam 46 and resetcam 44 co-operating couples the movement of the dosing and activating means back to the initial position, from which a dosage can be selected anew, to the zero-dosage position of thedosage indicator sleeve 40. This coupling is advantageously configured such that the movement of the dosing and activating means is only possible when thedosage indicator sleeve 40 assumes its zero-dosage position, and no other hand operations are required in order to trigger the resetting movement of the dosing and activating means. - In one embodiment of the present invention, the product delivery device of the exemplary embodiment may be used with or provided for an inhaler such as those known to those skilled in art, using which insulin is administered via the airways. The device of the invention serves to dose and deliver the product into an atomising chamber. The product thus provided in doses in the atomising chamber is atomised by an atomising means and administered through a chamber outlet via the airways, preferably orally. The front end of the front casing portion 1 is provided with a connector G formed as a thread, in order to be able to connect the device to the atomising chamber by threaded engagement.
- In some embodiments of the present invention, the device can also easily be used directly as an injection apparatus, by screwing a needle holder comprising an integrated injection needle of preferably 30 G or thinner, for example 31G, onto the front end of the front casing portion 1.
- In some embodiments, the device in accordance with the present invention could also be used with or provided for a pressure injector and, in this instance, be connected to a discharge means of the pressure injector. The device would supply the selected product dosage to the discharge means and the discharge means would discharge said product dosage at high pressure through an injection nozzle.
- In the foregoing description, embodiments of the present invention, including preferred embodiments, have been presented for the purpose of illustration and description. They are not intended to be exhaustive or to limit the invention to the precise forms and steps disclosed. Obvious modifications or variations are possible in light of the above teachings. The embodiments were chosen and described to provide the best illustration of the principals of the invention and its practical application, and to enable one of ordinary skill in the art to utilize the invention in various embodiments and with various modifications as are suited to the particular use contemplated. All such modifications and variations are within the scope of the invention as determined by the appended claims when interpreted in accordance with the breadth they are fairly, legally, and equitably entitled.
Claims (19)
1. An administering apparatus for administering an injectable product in selected doses, said administering apparatus comprising:
a) a casing configured to hold a reservoir containing the product;
b) a piston rod configured to act on the product to deliver a selected product dose from the reservoir;
c) a dose setting member for performing a dosing movement and for causing delivery of a selected dose, said dose setting member operably coupled to the piston rod such that a delivery movement of the dose setting member causes the selected product dose to be delivered via actuation of the piston rod;
d) a dose indicator sleeve coupled to the dose setting member such that the dose indicator sleeve is moved relative to the casing by the dosing movement of the dose setting member to indicate the selected product dose, the dose indicator sleeve comprising a reset cam protruding from the dose indicator sleeve; and
e) a blocking member in a blocking engagement with the dose setting member in the front end position of the dose setting member to prevent the dose setting member from moving counter to an activating direction;
f) wherein the blocking member comprises a counter reset cam protruding from the blocking member, and in a zero-dose position of the dose indicator sleeve, said reset cam and counter reset cam engage such that the blocking member is pressed out of the blocking engagement with the dose setting member.
2. The administering apparatus as set forth in claim 1 , wherein the dose indicator sleeve surrounds the blocking member and the reset cam protrudes from an inner surface area of the dose indicator sleeve.
3. The administering apparatus as set forth in claim 2 , wherein the reset cam is widened on at least one side, as far as the inner surface area of the dose indicator sleeve.
4. The administering apparatus as set forth in claim 1 , wherein the blocking member comprises an at least partially annular body, and an elasticity force acts on a side of the at least partially annular body opposite the counter reset cam with respect to a central longitudinal axis of the at least partially annular body and is directed toward the counter reset cam.
5. The administering apparatus as set forth in claim 1 , wherein the dose indicator sleeve is coupled to the casing via a threaded engagement which defines the movement of the dose indicator sleeve.
6. The administering apparatus as set forth in claim 5 , further comprising a mechanism holder coupled to the casing such that the mechanism holder is nonmovable with respect to the dosing movement and the delivery movement, said mechanism holder comprising an outer thread and the dose indicator sleeve comprising an inner thread, said threads in engagement with each other.
7. The administering apparatus as set forth in claim 1 , wherein an upper surface area of the dose indicator sleeve comprises a dose scale encircling a longitudinal axis of the dose indicator sleeve in a spiral.
8. The administering apparatus as set forth in claim 1 , wherein the blocking member is pressed against the dose setting member, transversely with respect to the activating direction, by the elasticity force of a spring element, and the dose setting member comprises a cavity toward which the blocking member presses during the delivery movement of the dose setting member, wherein the blocking member is pressed into said cavity to establish the blocking engagement in the front end position of the dose setting member.
9. The administering apparatus as set forth in claim 8 , wherein the reset cam is tapered in a circumferential direction in an area that presses against the counter reset cam such that the reset cam moves the blocking member out of cavity of the dose setting member.
10. The administering apparatus as set forth in claim 9 , wherein the reset cam moves the blocking member out of the cavity against the restoring force of the spring element.
11. The administering apparatus as set forth in claim 9 , further comprising a restoring spring coupled to the dose setting member for exerting a restoring force on the dose setting member, such that when the blocking engagement is released upon movement of the blocking member out of the cavity, the restoring spring presses the dose setting member out of the front end position and into a dose selection position.
12. The administering apparatus as set forth in claim 1 , further comprising a transfer member operably coupled to the dose setting member and to the piston rod, wherein the delivery movement of the dose setting member into the front end position moves the piston rod, via the transfer member, to cause the selected product dose to be delivered.
13. The administering apparatus as set forth in claim 12 , wherein the dose setting member comprises an activating part protruding out of the casing and is movable in the activating direction relative to the transfer member, against an elasticity force, to enable the dose setting member to spring-deflect in the front end position.
14. The administering apparatus as set forth in claim 13 , wherein the blocking member forms the blocking engagement with the activating part.
15. The administering apparatus as set forth in claim 14 , wherein the blocking member forms a stopper for the activating part, and wherein said stopper stops the activating part moving in the activating direction.
16. The administering apparatus as set forth in claim 1 , wherein the dose setting member is coupled to the dose indicator sleeve, secured against rotating in the dose selection position, but such that it can move in the activating direction relative to the dose indicator sleeve.
17. The administering apparatus as set forth in claim 1 , wherein the operable coupling between the dose setting member and the dose indicator sleeve causes the dose indicator sleeve to be slaved during the dosing movement of the dose setting member, but permits the delivery movement of the dose setting member relative to the dose indicator sleeve.
18. The administering apparatus as set forth in claim 17 , wherein the operable coupling is released in the front end position of the dose setting member.
19. The administering apparatus as set forth in claim 1 , wherein the dosing movement is a rotational movement about a rotational axis and the delivery movement is a translational movement along the rotational axis.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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US12/396,685 US20090221973A1 (en) | 2002-06-28 | 2009-03-03 | Administering apparatus with a resettable activating block |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
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DE10229122A DE10229122B4 (en) | 2002-06-28 | 2002-06-28 | Administration device with resettable actuation lock |
DEDE10229122A1 | 2002-06-28 | ||
DE10229138A DE10229138B4 (en) | 2002-06-28 | 2002-06-28 | Product diverter with piston rod emergency reset |
PCT/CH2003/000420 WO2004002557A1 (en) | 2002-06-28 | 2003-06-25 | Administering device comprising a resettable actuation lock |
US11/023,297 US7500966B2 (en) | 2002-06-28 | 2004-12-27 | Administering apparatus with a resettable activating block |
US12/396,685 US20090221973A1 (en) | 2002-06-28 | 2009-03-03 | Administering apparatus with a resettable activating block |
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US11/023,297 Continuation US7500966B2 (en) | 2002-06-28 | 2004-12-27 | Administering apparatus with a resettable activating block |
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US20090221973A1 true US20090221973A1 (en) | 2009-09-03 |
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Application Number | Title | Priority Date | Filing Date |
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US11/023,297 Expired - Fee Related US7500966B2 (en) | 2002-06-28 | 2004-12-27 | Administering apparatus with a resettable activating block |
US11/023,285 Expired - Fee Related US7445613B2 (en) | 2002-06-28 | 2004-12-27 | Product delivery device with rapid piston rod setting |
US12/255,988 Expired - Fee Related US7842016B2 (en) | 2002-06-28 | 2008-10-22 | Product delivery device with rapid piston rod setting |
US12/396,685 Abandoned US20090221973A1 (en) | 2002-06-28 | 2009-03-03 | Administering apparatus with a resettable activating block |
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Application Number | Title | Priority Date | Filing Date |
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US11/023,297 Expired - Fee Related US7500966B2 (en) | 2002-06-28 | 2004-12-27 | Administering apparatus with a resettable activating block |
US11/023,285 Expired - Fee Related US7445613B2 (en) | 2002-06-28 | 2004-12-27 | Product delivery device with rapid piston rod setting |
US12/255,988 Expired - Fee Related US7842016B2 (en) | 2002-06-28 | 2008-10-22 | Product delivery device with rapid piston rod setting |
Country Status (9)
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US (4) | US7500966B2 (en) |
EP (1) | EP1519766B1 (en) |
JP (2) | JP4485942B2 (en) |
CN (1) | CN100457208C (en) |
AT (1) | ATE409056T1 (en) |
AU (2) | AU2003232577A1 (en) |
DE (3) | DE10229122B4 (en) |
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Also Published As
Publication number | Publication date |
---|---|
JP4485942B2 (en) | 2010-06-23 |
US7842016B2 (en) | 2010-11-30 |
DE10229122A1 (en) | 2004-02-05 |
DK1519766T3 (en) | 2009-02-02 |
DE10229138B4 (en) | 2008-01-31 |
JP2005531348A (en) | 2005-10-20 |
EP1519766A1 (en) | 2005-04-06 |
ATE409056T1 (en) | 2008-10-15 |
JP4302627B2 (en) | 2009-07-29 |
AU2003232576A1 (en) | 2004-01-19 |
AU2003232576B2 (en) | 2006-07-06 |
DE10229122B4 (en) | 2006-09-07 |
DE50310544D1 (en) | 2008-11-06 |
US7445613B2 (en) | 2008-11-04 |
EP1519766B1 (en) | 2008-09-24 |
JP2005531349A (en) | 2005-10-20 |
US20090137967A1 (en) | 2009-05-28 |
US20050137534A1 (en) | 2005-06-23 |
DE10229138A1 (en) | 2004-01-29 |
CN1678362A (en) | 2005-10-05 |
WO2004002557A1 (en) | 2004-01-08 |
CN100457208C (en) | 2009-02-04 |
WO2004002556A1 (en) | 2004-01-08 |
US20050137571A1 (en) | 2005-06-23 |
US7500966B2 (en) | 2009-03-10 |
AU2003232577A1 (en) | 2004-01-19 |
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Legal Events
Date | Code | Title | Description |
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STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |