US20090205657A1 - Pre-metered dose magazine for dry powder inhaler - Google Patents
Pre-metered dose magazine for dry powder inhaler Download PDFInfo
- Publication number
- US20090205657A1 US20090205657A1 US12/321,209 US32120909A US2009205657A1 US 20090205657 A1 US20090205657 A1 US 20090205657A1 US 32120909 A US32120909 A US 32120909A US 2009205657 A1 US2009205657 A1 US 2009205657A1
- Authority
- US
- United States
- Prior art keywords
- magazine
- canceled
- housing
- reservoirs
- dry powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0021—Mouthpieces therefor
- A61M15/0025—Mouthpieces therefor with caps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0043—Non-destructive separation of the package, e.g. peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0061—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using pre-packed dosages having an insert inside
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Definitions
- the present disclosure relates to a dry powder inhaler for administering dry powder medicament to a patient. More particularly, the present disclosure relates to a magazine having a plurality of individually separated, pre-metered doses for a breath-actuated dry powder inhaler and a method for providing pre-metered doses of dry powder medicament for inhalation by a patient.
- Metered dose medicament inhalers are well known for dispensing medicament to the lungs of a patient.
- the inhalers include a reservoir containing dry powder medicament in bulk form, and means for metering the medicament from the reservoir in discrete amounts for inhalation by a patient.
- U.S. Pat. No. 5,503,144 which is assigned to the assignee of the present disclosure shows a breath-actuated dry-powder inhaler having a medicament reservoir.
- the reservoir contains dry powder medicament in bulk form, and the inhaler includes a metering chamber for removal of the powdered medicament from the reservoir in discrete amounts.
- the inhaler also includes an air inlet for entraining the removed powdered medicament through a mouthpiece upon patient inhalation.
- the reservoir and metering chamber of the inhaler shown by U.S. Pat. No. 5,503,144 properly function to dispense discrete amounts of powdered medicament to a patient.
- U.S. Pat. No. 6,655,381 which is assigned to the assignee of the present disclosure shows a pre-metered dose assembly for consistently supplying precise doses of medicament for a dry powder inhaler.
- the assembly includes a cap defining a dry powder delivery passageway and a magazine including a plurality of separate reservoirs for holding pre-metered doses of dry powder.
- the cap is movable with respect to the magazine for sequentially positioning the reservoirs within the delivery passageway of the cap.
- a breath-induced low pressure through the dry powder delivery passageway of the assembly entrains dry powder from the reservoir positioned in the passageway for inhalation by a patient using the inhaler.
- Providing the powdered medicament in pre-metered doses further ensures that the medicament is consistently dispensed to a patient in precise doses.
- the dry powder inhaler will also preferably include a magazine having a plurality of individually separated and sealed, pre-metered doses and mechanisms for advancing the magazine during use and for deploying the doses from the magazine for inhalation by a patient using the inhaler.
- the present disclosure provides a dry powder inhaler including a housing having a mouthpiece and a delivery passageway connected to the mouthpiece, a magazine positioned within the housing and including a plurality of reservoirs for holding doses of dry powder, and wherein the magazine is movable within the housing so that the reservoirs are sequentially positioned within the delivery passageway of the housing upon movement of the magazine, a cover connected to the housing and movable to open and close the mouthpiece of the housing, and a rake connected to the cover, extending into the housing and engageable with the magazine so that, upon the cover being moved to open the mouthpiece, the rake moves the magazine and causes one of the reservoirs of the magazine to be positioned within the delivery passageway.
- FIG. 1 is a side and top isometric view of an exemplary embodiment of a dry powder inhaler according to the present disclosure including a housing having a mouthpiece cover shown in a closed position;
- FIG. 2 is a front and top isometric view of the inhaler of FIG. 1 , with the mouthpiece cover shown in an opened position to expose a mouthpiece of the inhaler;
- FIG. 3 is a bottom plan view of an upper portion of the housing of the inhaler of FIG. 1 ;
- FIG. 4 is a top plan view of a lower portion of the housing of the inhaler of FIG. 1 ;
- FIG. 5 is a top plan view of a dose magazine of the inhaler of FIG. 1 ;
- FIG. 6 is a side elevation view of the dose magazine of the inhaler of FIG. 1 ;
- FIG. 7 is a top plan view of a cup-like base of a de-agglomerator of the inhaler of FIG. 1 ;
- FIG. 8 is a bottom isometric view of a top piece of the de-agglomerator of the inhaler of FIG. 1 ;
- FIG. 9 is a side elevation view of the cup-like base of the de-agglomerator of the inhaler of FIG. 1 ;
- FIG. 10 is a top plan view of the mouthpiece cover of the inhaler of FIG. 1 , showing a magazine advancement rake pivotally extending from the cover;
- FIG. 11 is a side elevation view of the mouthpiece cover and advancement rake of the inhaler of FIG. 1 ;
- FIG. 12 is a top plan view of an exemplary embodiment of a dose magazine constructed in accordance with the present disclosure.
- FIG. 13 is a sectional view of the dose magazine taken along line 13 - 13 of FIG. 12 ;
- FIG. 14 is a top plan view of the dose magazine of FIG. 12 , shown with an upper foil layer removed;
- FIG. 15 is a top plan view of another exemplary embodiment of a dose magazine constructed in accordance with the present disclosure.
- FIG. 16 is a sectional view of the dose magazine taken along line 16 - 16 of FIG. 15 ;
- FIG. 17 is a top plan view of an additional exemplary embodiment of a dose magazine constructed in accordance with the present disclosure.
- FIG. 18 is a sectional view of the dose magazine taken along line 18 - 18 of FIG. 17 ;
- FIG. 19 is a top perspective view of a portion of a further exemplary embodiment of a dose magazine constructed in accordance with the present disclosure, and including a foil removal mechanism;
- FIG. 20 is a top plan view of a further exemplary embodiment of a dose magazine constructed in accordance with the present disclosure.
- FIG. 21 is a sectional view of the dose magazine taken along line 21 - 21 of FIG. 20 , showing a deployable medicament piston of the dose magazine;
- FIG. 22 is a sectional view of exemplary embodiments of a dose magazine, a medicament piston, and an actuator, which is shown deploying the piston, all constructed in accordance with the present disclosure
- FIG. 23 is a perspective view of the actuator of FIG. 22 ;
- FIG. 24 is a side perspective view of additional exemplary embodiments of a dose magazine, a mouthpiece cover and an actuator, all constructed in accordance with the present disclosure, and wherein the actuator is adapted to cause a medicament piston to be deployed from the magazine upon the mouthpiece cover being opened;
- FIG. 25 is a front perspective view of the dose magazine, the mouthpiece cover and the actuator of FIG. 24 ;
- FIG. 26 is a sectional view of a further exemplary embodiment of a dose magazine, a medicament piston, and an actuator shown deploying the piston, all constructed in accordance with the present disclosure
- FIGS. 27 through 30 are side views of various exemplary embodiments of medicament pistons constructed in accordance with the present disclosure.
- FIG. 31 is a side elevation view of another exemplary embodiment of a medicament piston constructed in accordance with the present disclosure.
- FIG. 32 is a top plan view of the medicament piston of FIG. 31 ;
- FIG. 33 is a side elevation view of an additional exemplary embodiment of a medicament piston constructed in accordance with the present disclosure.
- FIG. 34 is a top plan view of the medicament piston of FIG. 33 ;
- FIG. 35 is a side elevation view of another exemplary embodiment of a medicament piston constructed in accordance with the present disclosure.
- FIG. 36 is a top plan view of the medicament piston of FIG. 35 ;
- FIG. 37 is a side elevation view of an additional exemplary embodiment of a medicament piston constructed in accordance with the present disclosure.
- FIG. 38 is a top plan view of the medicament piston of FIG. 37 ;
- FIG. 39 is a top perspective view of a further exemplary embodiment of a dose magazine constructed in accordance with the present disclosure.
- FIG. 40 is a side elevation view of exemplary embodiments of a dose magazine, an actuator for causing deployment of a medicament piston from the magazine, and an adjustment mechanism for adjusting the magnitude of deployment produced by the actuator, all constructed in accordance with the present disclosure;
- FIG. 42 is a side perspective view of a portion of the dose magazine of FIG. 41 , wherein a set of the medicament pistons is shown deployed, or extended upwardly, from a top surface of the magazine;
- FIG. 43 is a side elevation view of a portion of the dose magazine of FIG. 41 , showing a set of actuators for causing deployment of a set of the medicament pistons from the magazine, and wherein the actuators can be manipulated as desired to cause one or more of the pistons to be deployed;
- FIG. 44 is an end elevation view of a portion of the dose magazine of FIG. 41 , showing the set of actuators, wherein two out of four of the actuators have been manipulated to cause deployment of pistons;
- FIG. 45 is a top and side perspective view of a further exemplary embodiment of a dose magazine constructed in accordance with the present disclosure and including bores for receiving deployable medicament pistons, and wherein the bores extend radially with respect to an axis of the magazine;
- FIG. 46 is a sectional view of one of the bores of the dose magazine of FIG. 45 ;
- FIG. 47 is a top and side perspective view of another exemplary embodiment of a dose magazine constructed in accordance with the present disclosure and including bores for receiving deployable medicament pistons, wherein the bores extend radially and upwardly at an angle with respect to an axis of the magazine;
- FIG. 48 is a sectional view of one of the bores of the dose magazine of FIG. 47 ;
- FIG. 49 is a top plan view of an additional exemplary embodiment of a dose magazine constructed in accordance with the present disclosure and including bores for receiving deployable medicament pistons, wherein the bores extend tangentially with respect to the magazine;
- FIG. 50 is a top and side perspective view of another exemplary embodiment of a dose magazine constructed in accordance with the present disclosure and including bores for receiving deployable medicament pistons, wherein the bores are positioned at an outer circumference of the magazine and extend axially with respect to an axis of the magazine;
- FIG. 51 is a top plan view of a further exemplary embodiment of a rotatable dose magazine constructed in accordance with the present disclosure and including radially extending teeth for engaging a pawl, as shown, to prevent reverse rotation of the magazine and to provide an indication of the advancement of a final dose of the magazine;
- FIGS. 52 and 53 are side elevation views of an exemplary embodiment of a pawl constructed in accordance with the present disclosure, for engaging a dose magazine;
- FIG. 54 is a top plan view of another exemplary embodiment of a rotatable dose magazine constructed in accordance with the present disclosure and including radially extending medicament dose containers, and wherein a fixed blade is positioned for successively opening the dose containers upon rotation of the magazine;
- FIG. 55 is a side elevation view of an exemplary embodiment of a straw constructed in accordance with the present disclosure and including medicament dose containers, and wherein an exemplary embodiment of a blade constructed in accordance with the present disclosure for successively opening the dose containers upon linear movement of the straw is shown;
- FIG. 56 is a side elevation view of another exemplary embodiment of a straw constructed in accordance with the present disclosure and including medicament dose containers, and wherein parallel layers of the straw are pealed apart and wound to cause linear movement of the straw and successively open the dose containers;
- FIG. 57 is a side elevation view of an exemplary embodiment of a medicament dose carrier constructed in accordance with the present disclosure and having doses of medicament attached to a surface of the carrier, and wherein the carrier is shown being worked around a sharp corner to release doses of the medicament from the carrier as the carrier is bent around the corner; and
- FIG. 58 is a side elevation view of a further exemplary embodiment of a straw constructed in accordance with the present disclosure and including medicament dose containers, and wherein the straw is shown being worked around a sharp corner to successively open the dose containers as the containers are bent around the corner.
- FIGS. 1 and 2 show an exemplary embodiment of a dry powder inhaler 10 constructed in accordance with the present disclosure.
- the dry powder inhaler 10 includes a pre-metered dose magazine 12 (not viewable in FIGS. 1 and 2 but shown in FIGS. 5 and 6 ) that consistently furnishes precise doses of dry powder, e.g., a dry powder medicament or medicament composition, for inhalation by a patient using the dry powder inhaler 10 .
- the inhaler 10 includes a housing 18 having an upper portion 20 mated to a lower portion 22 .
- FIG. 3 is a bottom plan view of the upper portion 20 of the housing 18
- FIG. 4 is a top plan view of the lower portion 22 of the housing.
- FIGS. 5 and 6 show the dose magazine 12 of the inhaler of FIGS. 1 and 2
- FIGS. 7 and 9 show a cup-like base 24 of a de-agglomerator of the inhaler 10 of FIGS. 1 and 2
- FIG. 8 shows a top piece 26 of the de-agglomerator.
- the cup-like base 24 is received in the lower portion 22 of the housing 18 and the dose magazine 12 is received for rotation over the top piece 26 of the de-agglomerator and guided by the upper portion 20 of the housing 18 .
- the magazine 12 is movable with respect to the upper portion 20 of the housing 18 for sequentially positioning reservoirs 30 of the magazine 12 within a delivery passageway 32 of the upper portion. Then, a breath-induced low pressure at an outlet port 34 (shown in FIGS. 7 and 9 ) of the de-agglomerator causes an air flow, through the dry powder delivery passageway 32 into a dry powder supply port 36 (shown in FIG. 8 ) of the de-agglomerator.
- the passageway 32 of the upper portion 20 includes a venturi (or venturi-type restriction) that causes the velocity of the breath-induced air flow to increase.
- the air pressure in the venturi decreases as a result of the increased velocity, and the drop in pressure causes the pre-metered dose of dry powder to be dragged from the reservoir 30 aligned with the passageway 32 , and entrained into the air flow traveling to the de-agglomerator.
- the magazine 12 is movable with respect to the upper portion 20 of the housing for sequentially positioning the dry powder reservoirs 30 of the magazine within the delivery passageway 32 of the upper portion.
- the magazine 12 could be made stationary, and the upper portion 20 made movable with respect to the magazine for sequentially positioning the passageway over the reservoirs.
- the magazine 12 is provided with an annular shape such that rotation of the annular magazine sequentially positions the plurality of the dry powder reservoirs 30 within the delivery passageway 32 of the upper portion 20 of the housing 18 .
- the annular magazine 12 includes teeth 40 extending radially outwardly that are engaged by a pivotal rake 42 of the mouthpiece cover 14 for advancing the magazine 12 upon the cover 14 being opened.
- FIGS. 10 and 11 show the magazine advancement rake 42 pivotally extending from the cover 14 .
- the engagement rake 42 engages the teeth 40 of the magazine 12 to rotate and advance the magazine 12 upon the mouthpiece cover 14 being opened.
- the dry powder reservoirs 30 are provided in the top surface of the magazine 12 and are uniformly sized and spaced with respect to one another.
- the magazine 12 preferably includes a seal over the top surface for sealing the doses of dry powder in the reservoirs 30 of the magazine in a moisture resistant and airtight manner prior to the reservoirs being positioned within the delivery passageway 32 of the upper portion 20 .
- the seal can comprise, for example, a metal foil secured to the annular top surface of the magazine 12 with adhesive and covering the dry powder in the reservoirs 30 in a moisture resistant and airtight manner.
- the upper portion 20 of the housing 18 can include means for piercing the foil above each of the reservoirs 30 prior to the reservoirs being positioned within the delivery passageway 32 of the upper portion.
- the means for piercing can comprise, for example, a blade extending downward from the upper portion 20 of the housing 18 in front of the venturi of the delivery passageway 32 .
- the reservoirs 30 of the magazine 12 will fill with properly metered individual doses of dry powder medicament, or a medicament composition including medicament and a suitable particulate carrier such as lactose.
- the filled reservoirs 30 are then sealed in a moisture resistant and airtight manner, with the foil for example, and the magazine 12 and the upper portion 20 of the housing 18 are provided assembled as part of the inhaler 10 .
- the inhaler 10 and the magazine 12 may be disposable.
- the dose magazine 12 may be removably insertable into a non-disposable inhaler 10 so that an empty magazine can be replaced by a full magazine.
- the magazine 12 is movable with respect to the upper portion 20 of the housing 18 through a plurality of discrete increments, wherein at each increment one of the plurality of the dry powder reservoirs 30 of the magazine is positioned within the delivery passageway 32 of the upper portion.
- the magazine 12 is preferably movable in a single direction only with respect to the housing 18 , so that a user can access the reservoirs 30 in sequence, without being able to access one of the reservoirs 30 more than once.
- movement between the magazine 12 and the upper portion 20 of the housing is preferably prevented after all the dry powder reservoirs 30 of the magazine have been positioned in the delivery passageway 32 of the upper portion, to provide an indication to a patient that all of the doses of the magazine have been used.
- the magazine 12 is provided with a radially inwardly extending catch 44 , as shown in FIG. 5 , that prevents further rotation of the magazine upon all of the reservoirs 30 passing through the delivery passageway 32 of the housing 18 .
- the inhaler 10 can also include an indicator for indicating the number of dry powder reservoirs 30 containing dry powder, i.e., the number of pre-metered doses remaining in the magazine 12 .
- the indicator can comprise, for example, sequential printed numbers corresponding to the reservoirs 30 of the magazine 12 provided on the outer surface of the magazine, so that the number of reservoirs that have passed through the delivery passageway 32 of the upper portion 20 of the housing 18 can be determined by partly opening the cover 14 (without causing the magazine to advance) and viewing the numbers on the magazine.
- the inhaler can also be provided with a lock for locking the mouthpiece cover 14 in an opened or closed position upon the advancement of a final medicament reservoir of the magazine.
- the de-agglomerator breaks down agglomerates of dry powder before inhalation of the dry powder by a patient.
- the de-agglomerator includes two diametrically opposed inlet ports 46 that extend in a direction substantially tangential to the circular cross-section of the swirl chamber formed within the de-agglomerator.
- air flows entering the chamber through the inlet ports 46 are at least initially directed transverse with respect to the chamber and collide with the air flow entering through the supply port to create a combined turbulent air flow.
- the de-agglomerator includes vanes 48 at the first end of the swirl chamber 52 .
- the vanes 48 are sized such that at least a portion of the combined air flows collide with oblique surfaces of the vanes.
- the geometry of the swirl chamber 52 causes the combined air flows and the entrained dry powder to follow a turbulent spiral path, or vortex, through the chamber.
- particles and any agglomerates of the dry powder constantly impact against the wall of the swirl chamber and collide with each other, resulting in a mutual grinding or shattering action between the particles and agglomerates.
- particles and agglomerates deflected off the oblique surfaces of the vanes 48 cause further impacts and collisions.
- the constant impacts and collisions cause any agglomerates of dry powder to break into additional particles, and cause the particles to be substantially micronized.
- the direction of the combined air flow and the entrained dry powder is again changed through the outlet port 34 , which extends through the mouthpiece 16 of the housing 18 .
- the combined air flow and the entrained dry powder retain a swirl component of the flow, such that the air flow and the entrained dry powder spirally swirl through the outlet port 34 . Since the micronized powder and any remaining agglomerates maintain the swirl imparted from the swirl chamber, the swirling flow causes additional impacts in the outlet port 34 so as to result in further breaking up of any remaining agglomerates prior to being inhaled by a patient.
- the de-agglomerator therefore, ensures that particles of the dry powder are small enough for adequate penetration of the powder into a bronchial region of a patient's lungs during inhalation.
- the de-agglomerator is assembled from two pieces: the cup-like base 24 shown in FIGS. 7 and 9 , and the top piece 26 shown in FIG. 8 , which are connected together to form the swirl chamber 52 within the de-agglomerator.
- the cup-like base 24 is secured in the lower portion 22 of the housing 18 and defines the outlet port 34 and the inlet ports 46 .
- the top piece 26 forms the vanes 48 and defines the supply port 36 .
- the top piece 26 also includes an upwardly extending cylindrical guide 50 , and a chimney (not viewable) extending upwardly from the supply port 36 within the guide, as shown best in FIG. 8 .
- the inner circumference of the annular magazine 12 is received coaxially on the guide 50 , such that the magazine can be rotated about the guide.
- a hood of the upper portion 20 of the housing 18 is received over the chimney of the supply port 36 to connect the delivery passageway 32 of the upper portion 30 with the supply port 36 of the de-agglomerator.
- the de-agglomerator, the magazine and the housing are preferably manufactured from a plastic such as polypropylene, acetal or moulded polystyrene, but may be manufactured from metal or another suitable material.
- the inhaler of FIGS. 1 through 11 may be used for any drug formulation which may be advantageously administered to the lung or nasal passages in an animal, to cure or alleviate any illness or its symptoms.
- Many medicaments, bioactive active substances and pharmaceutical compositions may be included in the dosage forms of the present invention.
- Non-limiting examples of classes of drugs contemplated for use include ace-inhibitors, acne drugs, alkaloids, amino acid preparations, anabolic preparations, analgesics, anesthetics, antacids, antianginal drugs, anti-anxiety agents, anti-arrhythmias, anti-asthmatics, antibiotics, anti-cholesterolemics, anti-coagulants, anti-convulsants, anti-depressants, anti-diabetic agents, anti-diarrhea preparations, antidotes, anti-emetics, anti-histamines, anti-hypertensive drugs, anti-inflammatory agents, anti-lipid agents, anti-manics, anti-nauseants, anti-neoplastics, anti-obesity drugs, anti-parkinsonism agents, anti-psychotics, anti-pyretics, anti-rheumatic agents, anti-spasmodics, anti-stroke agents, anti-thrombotic drugs, anti-thyroid preparation
- the dosage form for use with the invention comprises anti-inflammatory agents suitable for inhalation administration.
- anti-inflammatory agents may include, for example, bronchodilators and steroids.
- Representative ⁇ 2 -adrenergic receptor agonist bronchodilators include, without limitation, salmeterol, formoterol, bambuterol, albuterol, terbutaline, pirbuterol, bitolterol, metaproterenol, isoetharine, isoproterenol, fenoterol, or procaterol.
- Non-limitating anti-inflammatory steroids contemplated for use with the invention include budesonide, beclomethasone, fluticasone, and triamcinolone diacetate.
- Additional anti-inflammatory agents contemplated include ipatropium bromide and sodium cromoglycate.
- Therapeutically effective formulations and dosages to be administered using the devices described herein are well known to practitioners.
- practitioners may opt to alter dosages and/or formulations to fit a particular patient/animal need.
- FIGS. 12 through 14 show an exemplary embodiment of a dose magazine 60 constructed in accordance with the present disclosure.
- the dose magazine 60 can be used, for example, with the inhaler of FIGS. 1 through 11 .
- the dose magazine 60 includes medicament reservoirs in the form of axial bores 62 for receiving medicament.
- the dose magazine 60 also includes a lower layer 64 of moisture resistant, air-tight material covering a lower surface of the magazine and an upper layer 66 of moisture resistant, air-tight material covering an upper surface of the magazine and enclosing medicament in the bores 62 of the magazine in a dry, air-tight manner. As shown best in FIG.
- the upper layer 66 of moisture resistant, air-tight material can be provided with domes 68 over the medicament bores 62 so that a blade 70 can be positioned to successively cut open the domes 68 and release the medicament upon rotation of the magazine 60 .
- the moisture resistant, air-tight material can comprise, for example, metal foil secured to the magazine with adhesive.
- the foil layers may include selective adhesive, e.g., no adhesive positioned in contact with the medicament, in order to maintain dose uniformity.
- the moisture resistant, air-tight material can also comprise, for example, a laminate of metal foil secured to a layer of plastic, which in turn is secured to the magazine with adhesive.
- FIGS. 15 and 16 show another exemplary embodiment of a dose magazine 80 constructed in accordance with the present disclosure.
- the magazine 80 includes medicament reservoirs 82 and each medicament reservoir includes a lining 84 of moisture resistant, air-tight material, such as a metal insert or foil.
- FIGS. 17 and 18 show an additional exemplary embodiment of a dose magazine 90 constructed in accordance with the present disclosure.
- the magazine 90 includes medicament reservoirs 92 formed in a trough 94 of a first material, such as plastic, which is formed in a trough 96 of moisture resistant, air-tight material, such as a metal.
- the metal trough 96 can be pre-formed via stamping or metal injection molding.
- the metal trough 96 can also be formed from a metal foil.
- FIG. 19 shows a further exemplary embodiment of a dose magazine 100 constructed in accordance with the present disclosure, and including a foil removal mechanism 102 .
- the foil removal mechanism comprises a rotatable winding wheel 102 which peels an upper layer 104 of moisture resistant, air-tight material, such as metal foil, from an upper surface of the magazine 100 as the magazine is rotated. As the foil 104 is peeled from the magazine 100 , medicament reservoirs 106 are uncovered to allow inhalation of the medicament therein.
- the foil removal mechanism 102 can also be adapted and used to index the magazine 100 .
- FIGS. 20 and 21 show a further exemplary embodiment of a dose magazine 110 constructed in accordance with the present disclosure.
- the dose magazine 110 includes axial bores 112 containing deployable medicament pistons 114 sealed between layers 116 , 118 of moisture resistant, air-tight material, such as metal foil.
- the pistons 114 each have at least one compartment 120 holding at least one dose of powder medicament, which are presented for inhalation upon the pistons 114 being pushed upwardly through the upper layer 116 of foil.
- FIG. 22 shows exemplary embodiments of a dose magazine 130 , a medicament piston 132 , and an actuator 134 , which is shown deploying the piston, all constructed in accordance with the present disclosure.
- FIG. 23 is a perspective view of the actuator 134 of FIG. 22 . As the magazine 130 is linearly moved over the actuator 134 , the actuator 134 successively pushes the pistons 132 upwardly through the upper layer 116 of foil to expose a compartment 136 containing a dose of medicament for inhalation.
- FIGS. 24 and 25 show additional exemplary embodiments of a dose magazine 140 , a mouthpiece cover 142 and an actuator 144 , all constructed in accordance with the present disclosure, and wherein the actuator 144 is adapted to cause a medicament piston 146 to be deployed from the magazine 140 upon the mouthpiece cover 142 being opened.
- FIG. 26 shows a further exemplary embodiment of a dose magazine 150 , a medicament piston 152 , and an actuator 154 shown deploying the piston, all constructed in accordance with the present disclosure.
- the medicament piston 152 includes multiple, vertically arranged compartments in the form of shoulders 156 a , 156 b , 156 c for holding dry powder medicament.
- the piston 152 can be extended through the foil 116 so that only one shoulder 156 a out of the three shoulders 156 a , 156 b , 156 c of the piston extends above the foil so that a minimum dose is exposed for inhalation.
- the piston 152 can be extended through the foil 116 so that all of the shoulders 156 a , 156 b , 156 c of the piston extend above the foil so that a maximum dose is exposed for inhalation.
- FIGS. 27 through 30 show various exemplary embodiments of medicament pistons 160 , 162 , 164 , 166 constructed in accordance with the present disclosure.
- the piston 160 of FIG. 27 includes vertically arranged shoulders 168 a , 168 b , 168 c for supporting dry powder medicament, and the shoulders 168 a , 168 b , 168 c become smaller towards the bottom of the piston 160 .
- the piston 162 of FIG. 28 includes vertically arranged compartments 170 a , 170 b , 170 c for holding dry powder medicament, and the compartments 170 a , 170 b , 170 c become larger towards the bottom of the piston.
- the piston 164 of FIG. 29 includes vertically arranged shoulders 172 for holding dry powder medicament, and the shoulders are equally sized.
- the piston 166 of FIG. 30 includes vertically arranged compartments 174 for holding dry powder medicament, and the compartments are equally sized.
- FIGS. 31 through 38 show further exemplary embodiments of medicament pistons 180 , 182 , 184 , 186 constructed in accordance with the present disclosure.
- the piston 180 of FIGS. 31 and 32 has a circular cross-section and includes a single compartment 190 for holding dry powder medicament.
- the piston 182 of FIGS. 33 and 34 has a circular cross-section and includes vertically arranged shoulders 192 for holding dry powder medicament, and the shoulders 192 are equally sized.
- the piston 184 of FIGS. 35 and 36 has a rectangular cross-section and includes a single compartment 194 for holding dry powder medicament.
- the piston 186 of FIGS. 37 and 38 has a rectangular cross-section and includes vertically arranged compartments 196 for holding dry powder medicament, and the compartments 196 are equally sized.
- FIG. 39 is a top perspective view of a further exemplary embodiment of a dose magazine 200 constructed in accordance with the present disclosure.
- the dose magazine 200 includes examples of variously shaped and arranged bores for receiving deployable medicament pistons, such as the medicament pistons of FIGS. 27 through 38 , for example.
- the magazine 200 can include, for example, circular bores 202 that extend radially through the magazine or circular bores 204 that extend axially through the magazine.
- the magazine 200 can also include rectangular bores 206 that extend radially through the magazine or rectangular bores 208 that extend axially through the magazine.
- the magazine 200 can include a set 210 of radially arranged, rectangular bores or a set 212 of radially extending, rectangular bores.
- FIG. 40 shows exemplary embodiments of a dose magazine 220 , an actuator 222 for causing deployment of a medicament piston 224 from the magazine, and an adjustment mechanism 226 for adjusting the magnitude of deployment produced by the actuator, all constructed in accordance with the present disclosure.
- the adjustment mechanism 226 can be adjusted by a user to adjust the magnitude of deployment of the piston 224 produced by the actuator 222 , so that the amount of dry powder medicament exposed for inhalation can be adjusted.
- the adjustment mechanism 226 includes shims 228 which prevent full motion of actuator 222 , and a user can dial in the number of shims 228 corresponding to a desired dose.
- FIG. 41 is a top plan view of a further exemplary embodiment of a dose magazine 230 constructed in accordance with the present disclosure and including sets 232 of deployable medicament pistons
- FIG. 42 is a side perspective view of a portion of the dose magazine 230 of FIG. 41 , wherein a set 232 of the medicament pistons 234 a , 234 b , 234 c , 234 d is shown deployed, or extended upwardly, from a top surface of the magazine.
- 43 and 44 show a set 236 of actuators 238 a , 238 b , 238 c , 238 d for causing deployment of the set 232 of the medicament pistons 234 a , 234 b , 234 c , 234 d from the magazine.
- the actuators 238 a , 238 b , 238 c , 238 d can be manipulated as desired by a user to cause one or more of the pistons 234 a , 234 b , 234 c , 234 d to be deployed, so that the amount of dry powder medicament exposed for inhalation can be adjusted.
- FIGS. 45 and 46 show a further exemplary embodiment of a dose magazine 240 constructed in accordance with the present disclosure and including bores 242 for receiving deployable medicament pistons.
- the bores 242 extend radially with respect to an axis A of the magazine 240 .
- FIGS. 47 and 48 show another exemplary embodiment of a dose magazine 250 constructed in accordance with the present disclosure and including bores 252 for receiving deployable medicament pistons.
- the bores 252 extend radially and at an angle with respect to an axis A of the magazine 250 .
- FIG. 49 shows an additional exemplary embodiment of a dose magazine 260 constructed in accordance with the present disclosure and including bores 262 for receiving deployable medicament pistons.
- the bores 262 extend tangentially with respect to the magazine 260 .
- FIG. 50 shows a further exemplary embodiment of a dose magazine 270 constructed in accordance with the present disclosure and including bores 272 for receiving deployable medicament pistons.
- the bores 272 are positioned at an outer circumference of the magazine 270 and extend axially with respect to an axis A of the magazine.
- FIG. 51 shows a further exemplary embodiment of a rotatable dose magazine 280 constructed in accordance with the present disclosure and including radially extending teeth 282 for engaging a pawl 284 , as shown, to prevent reverse rotation of the magazine 280 and to provide an indication of the advancement of a final medicament reservoir 286 of the magazine.
- This mechanism can be used to increase the force required to advance the magazine 280 , increase noise or vibration, or provide other indication that the last medicament reservoir 286 is approaching and the inhaler should be refilled or replaced.
- FIGS. 52 and 53 show an exemplary embodiment of a pawl 294 constructed in accordance with the present disclosure, for engaging a dose magazine 290 .
- the pawl 294 can be adapted to provide a different sounding noise upon the advancement of a final medicament reservoir 296 and extending tooth 292 of the magazine 290 .
- FIG. 54 shows another exemplary embodiment of a rotatable dose magazine 300 constructed in accordance with the present disclosure and including radially extending medicament dose containers 302 and a fixed blade 304 for successively opening the dose containers upon rotation of the magazine.
- FIG. 55 shows an exemplary embodiment of a dose magazine 310 constructed in accordance with the present disclosure and including medicament dose containers 312 , and wherein an exemplary embodiment of a blade 314 constructed in accordance with the present disclosure for successively opening the dose containers 312 upon linear movement of the magazine 310 is shown.
- FIG. 56 shows another exemplary embodiment of a dose magazine 320 constructed in accordance with the present disclosure and including medicament dose containers 322 , and wherein parallel layers 324 , 326 of the dose magazine are peeled apart and wound to cause linear movement of the dose magazine 320 and successive opening of the dose containers 322 contained between the layers 324 , 326 .
- FIG. 57 shows an exemplary embodiment of a medicament dose magazine 330 constructed in accordance with the present disclosure and having doses 332 of medicament attached to a surface of the magazine 330 .
- the magazine 330 is made of elastic material and is drawn around a sharp corner 334 to successively release the doses 332 of the medicament from the magazine 330 as the magazine is bent around the corner 334 .
- FIG. 58 shows a further exemplary embodiment of a dose magazine 340 constructed in accordance with the present disclosure and including medicament dose containers 342 .
- the dose magazine 340 is drawn around a sharp corner 344 to successively open the dose containers 342 as the containers are bent around the corner.
Abstract
A dry powder inhaler including a housing having a mouthpiece and a delivery passageway connected to the mouthpiece, a magazine positioned within the housing and including a plurality of reservoirs for holding doses of dry powder, and wherein the magazine is movable within the housing so that the reservoirs are sequentially positioned within the delivery passageway of the housing upon movement of the magazine, a cover connected to the housing and movable to open and close the mouthpiece of the housing, and a rake connected to the cover, extending into the housing and engageable with the magazine so that, upon the cover being moved to open the mouthpiece, the rake moves the magazine and causes one of the reservoirs of the magazine to be positioned within the delivery passageway.
Description
- The present application is a continuation of U.S. application Ser. No. 10/783,796, filed Feb. 20, 2004, the disclosure of which is hereby incorporated by reference herein, and claims priority of United Kingdom Patent Application No. 0303870.0, filed on Feb. 20, 2003.
- The present disclosure relates to a dry powder inhaler for administering dry powder medicament to a patient. More particularly, the present disclosure relates to a magazine having a plurality of individually separated, pre-metered doses for a breath-actuated dry powder inhaler and a method for providing pre-metered doses of dry powder medicament for inhalation by a patient.
- Metered dose medicament inhalers are well known for dispensing medicament to the lungs of a patient. In most cases, the inhalers include a reservoir containing dry powder medicament in bulk form, and means for metering the medicament from the reservoir in discrete amounts for inhalation by a patient.
- For example, U.S. Pat. No. 5,503,144, which is assigned to the assignee of the present disclosure shows a breath-actuated dry-powder inhaler having a medicament reservoir. The reservoir contains dry powder medicament in bulk form, and the inhaler includes a metering chamber for removal of the powdered medicament from the reservoir in discrete amounts. The inhaler also includes an air inlet for entraining the removed powdered medicament through a mouthpiece upon patient inhalation. The reservoir and metering chamber of the inhaler shown by U.S. Pat. No. 5,503,144 properly function to dispense discrete amounts of powdered medicament to a patient.
- U.S. Pat. No. 6,655,381, which is assigned to the assignee of the present disclosure shows a pre-metered dose assembly for consistently supplying precise doses of medicament for a dry powder inhaler. The assembly includes a cap defining a dry powder delivery passageway and a magazine including a plurality of separate reservoirs for holding pre-metered doses of dry powder. The cap is movable with respect to the magazine for sequentially positioning the reservoirs within the delivery passageway of the cap. A breath-induced low pressure through the dry powder delivery passageway of the assembly entrains dry powder from the reservoir positioned in the passageway for inhalation by a patient using the inhaler. Providing the powdered medicament in pre-metered doses further ensures that the medicament is consistently dispensed to a patient in precise doses.
- What is still desired is a new and improved dry powder inhaler for administering dry powder medicament to a patient. The dry powder inhaler will also preferably include a magazine having a plurality of individually separated and sealed, pre-metered doses and mechanisms for advancing the magazine during use and for deploying the doses from the magazine for inhalation by a patient using the inhaler.
- The present disclosure provides a dry powder inhaler including a housing having a mouthpiece and a delivery passageway connected to the mouthpiece, a magazine positioned within the housing and including a plurality of reservoirs for holding doses of dry powder, and wherein the magazine is movable within the housing so that the reservoirs are sequentially positioned within the delivery passageway of the housing upon movement of the magazine, a cover connected to the housing and movable to open and close the mouthpiece of the housing, and a rake connected to the cover, extending into the housing and engageable with the magazine so that, upon the cover being moved to open the mouthpiece, the rake moves the magazine and causes one of the reservoirs of the magazine to be positioned within the delivery passageway.
- Further features and advantages of the presently disclosed pre-metered dose magazine and method for providing pre-metered doses will become more readily apparent to those having ordinary skill in the art to which the present disclosure relates from the following detailed description and attached drawings.
- So that those having ordinary skill in the art will more readily understand how to construct a pre-metered dose magazine and dry powder inhaler in accordance with the present disclosure, exemplary embodiments are described in detail below with reference to the drawing figures wherein:
-
FIG. 1 is a side and top isometric view of an exemplary embodiment of a dry powder inhaler according to the present disclosure including a housing having a mouthpiece cover shown in a closed position; -
FIG. 2 is a front and top isometric view of the inhaler ofFIG. 1 , with the mouthpiece cover shown in an opened position to expose a mouthpiece of the inhaler; -
FIG. 3 is a bottom plan view of an upper portion of the housing of the inhaler ofFIG. 1 ; -
FIG. 4 is a top plan view of a lower portion of the housing of the inhaler ofFIG. 1 ; -
FIG. 5 is a top plan view of a dose magazine of the inhaler ofFIG. 1 ; -
FIG. 6 is a side elevation view of the dose magazine of the inhaler ofFIG. 1 ; -
FIG. 7 is a top plan view of a cup-like base of a de-agglomerator of the inhaler ofFIG. 1 ; -
FIG. 8 is a bottom isometric view of a top piece of the de-agglomerator of the inhaler ofFIG. 1 ; -
FIG. 9 is a side elevation view of the cup-like base of the de-agglomerator of the inhaler ofFIG. 1 ; -
FIG. 10 is a top plan view of the mouthpiece cover of the inhaler ofFIG. 1 , showing a magazine advancement rake pivotally extending from the cover; -
FIG. 11 is a side elevation view of the mouthpiece cover and advancement rake of the inhaler ofFIG. 1 ; -
FIG. 12 is a top plan view of an exemplary embodiment of a dose magazine constructed in accordance with the present disclosure; -
FIG. 13 is a sectional view of the dose magazine taken along line 13-13 ofFIG. 12 ; -
FIG. 14 is a top plan view of the dose magazine ofFIG. 12 , shown with an upper foil layer removed; -
FIG. 15 is a top plan view of another exemplary embodiment of a dose magazine constructed in accordance with the present disclosure; -
FIG. 16 is a sectional view of the dose magazine taken along line 16-16 ofFIG. 15 ; -
FIG. 17 is a top plan view of an additional exemplary embodiment of a dose magazine constructed in accordance with the present disclosure; -
FIG. 18 is a sectional view of the dose magazine taken along line 18-18 ofFIG. 17 ; -
FIG. 19 is a top perspective view of a portion of a further exemplary embodiment of a dose magazine constructed in accordance with the present disclosure, and including a foil removal mechanism; -
FIG. 20 is a top plan view of a further exemplary embodiment of a dose magazine constructed in accordance with the present disclosure; -
FIG. 21 is a sectional view of the dose magazine taken along line 21-21 ofFIG. 20 , showing a deployable medicament piston of the dose magazine; -
FIG. 22 is a sectional view of exemplary embodiments of a dose magazine, a medicament piston, and an actuator, which is shown deploying the piston, all constructed in accordance with the present disclosure; -
FIG. 23 is a perspective view of the actuator ofFIG. 22 ; -
FIG. 24 is a side perspective view of additional exemplary embodiments of a dose magazine, a mouthpiece cover and an actuator, all constructed in accordance with the present disclosure, and wherein the actuator is adapted to cause a medicament piston to be deployed from the magazine upon the mouthpiece cover being opened; -
FIG. 25 is a front perspective view of the dose magazine, the mouthpiece cover and the actuator ofFIG. 24 ; -
FIG. 26 is a sectional view of a further exemplary embodiment of a dose magazine, a medicament piston, and an actuator shown deploying the piston, all constructed in accordance with the present disclosure; -
FIGS. 27 through 30 are side views of various exemplary embodiments of medicament pistons constructed in accordance with the present disclosure; -
FIG. 31 is a side elevation view of another exemplary embodiment of a medicament piston constructed in accordance with the present disclosure; -
FIG. 32 is a top plan view of the medicament piston ofFIG. 31 ; -
FIG. 33 is a side elevation view of an additional exemplary embodiment of a medicament piston constructed in accordance with the present disclosure; -
FIG. 34 is a top plan view of the medicament piston ofFIG. 33 ; -
FIG. 35 is a side elevation view of another exemplary embodiment of a medicament piston constructed in accordance with the present disclosure; -
FIG. 36 is a top plan view of the medicament piston ofFIG. 35 ; -
FIG. 37 is a side elevation view of an additional exemplary embodiment of a medicament piston constructed in accordance with the present disclosure; -
FIG. 38 is a top plan view of the medicament piston ofFIG. 37 ; -
FIG. 39 is a top perspective view of a further exemplary embodiment of a dose magazine constructed in accordance with the present disclosure; -
FIG. 40 is a side elevation view of exemplary embodiments of a dose magazine, an actuator for causing deployment of a medicament piston from the magazine, and an adjustment mechanism for adjusting the magnitude of deployment produced by the actuator, all constructed in accordance with the present disclosure; -
FIG. 41 is a top plan view of a further exemplary embodiment of a dose magazine constructed in accordance with the present disclosure and including sets of deployable medicament pistons; -
FIG. 42 is a side perspective view of a portion of the dose magazine ofFIG. 41 , wherein a set of the medicament pistons is shown deployed, or extended upwardly, from a top surface of the magazine; -
FIG. 43 is a side elevation view of a portion of the dose magazine ofFIG. 41 , showing a set of actuators for causing deployment of a set of the medicament pistons from the magazine, and wherein the actuators can be manipulated as desired to cause one or more of the pistons to be deployed; -
FIG. 44 is an end elevation view of a portion of the dose magazine ofFIG. 41 , showing the set of actuators, wherein two out of four of the actuators have been manipulated to cause deployment of pistons; -
FIG. 45 is a top and side perspective view of a further exemplary embodiment of a dose magazine constructed in accordance with the present disclosure and including bores for receiving deployable medicament pistons, and wherein the bores extend radially with respect to an axis of the magazine; -
FIG. 46 is a sectional view of one of the bores of the dose magazine ofFIG. 45 ; -
FIG. 47 is a top and side perspective view of another exemplary embodiment of a dose magazine constructed in accordance with the present disclosure and including bores for receiving deployable medicament pistons, wherein the bores extend radially and upwardly at an angle with respect to an axis of the magazine; -
FIG. 48 is a sectional view of one of the bores of the dose magazine ofFIG. 47 ; -
FIG. 49 is a top plan view of an additional exemplary embodiment of a dose magazine constructed in accordance with the present disclosure and including bores for receiving deployable medicament pistons, wherein the bores extend tangentially with respect to the magazine; -
FIG. 50 is a top and side perspective view of another exemplary embodiment of a dose magazine constructed in accordance with the present disclosure and including bores for receiving deployable medicament pistons, wherein the bores are positioned at an outer circumference of the magazine and extend axially with respect to an axis of the magazine; -
FIG. 51 is a top plan view of a further exemplary embodiment of a rotatable dose magazine constructed in accordance with the present disclosure and including radially extending teeth for engaging a pawl, as shown, to prevent reverse rotation of the magazine and to provide an indication of the advancement of a final dose of the magazine; -
FIGS. 52 and 53 are side elevation views of an exemplary embodiment of a pawl constructed in accordance with the present disclosure, for engaging a dose magazine; -
FIG. 54 is a top plan view of another exemplary embodiment of a rotatable dose magazine constructed in accordance with the present disclosure and including radially extending medicament dose containers, and wherein a fixed blade is positioned for successively opening the dose containers upon rotation of the magazine; -
FIG. 55 is a side elevation view of an exemplary embodiment of a straw constructed in accordance with the present disclosure and including medicament dose containers, and wherein an exemplary embodiment of a blade constructed in accordance with the present disclosure for successively opening the dose containers upon linear movement of the straw is shown; -
FIG. 56 is a side elevation view of another exemplary embodiment of a straw constructed in accordance with the present disclosure and including medicament dose containers, and wherein parallel layers of the straw are pealed apart and wound to cause linear movement of the straw and successively open the dose containers; -
FIG. 57 is a side elevation view of an exemplary embodiment of a medicament dose carrier constructed in accordance with the present disclosure and having doses of medicament attached to a surface of the carrier, and wherein the carrier is shown being worked around a sharp corner to release doses of the medicament from the carrier as the carrier is bent around the corner; and -
FIG. 58 is a side elevation view of a further exemplary embodiment of a straw constructed in accordance with the present disclosure and including medicament dose containers, and wherein the straw is shown being worked around a sharp corner to successively open the dose containers as the containers are bent around the corner. -
FIGS. 1 and 2 show an exemplary embodiment of adry powder inhaler 10 constructed in accordance with the present disclosure. Thedry powder inhaler 10 includes a pre-metered dose magazine 12 (not viewable inFIGS. 1 and 2 but shown inFIGS. 5 and 6 ) that consistently furnishes precise doses of dry powder, e.g., a dry powder medicament or medicament composition, for inhalation by a patient using thedry powder inhaler 10. - During use, the patient opens a
mouthpiece cover 14 of theinhaler 10, inhales, then closes the cover. Themouthpiece cover 14 is also shown inFIGS. 10 and 11 . The action of opening thecover 14 advances thepre-metered dose magazine 12, shown inFIGS. 5 and 6 , presenting a dose for inhalation. If thecover 14 is closed without taking the dose, that dose is contained within theinhaler 10, and is not presented again for inhalation. Thus, there is no possibility for unintentional double dosing. Partial opening of thecover 14 will allow the user to see an indication of the number of doses remaining without advancing the magazine. Due to the individually sealed doses within theinhaler 10, a level of moisture protection is present with this inhaler. - As shown in
FIGS. 1 and 2 , theinhaler 10 includes ahousing 18 having anupper portion 20 mated to alower portion 22.FIG. 3 is a bottom plan view of theupper portion 20 of thehousing 18, andFIG. 4 is a top plan view of thelower portion 22 of the housing.FIGS. 5 and 6 show thedose magazine 12 of the inhaler ofFIGS. 1 and 2 , andFIGS. 7 and 9 show a cup-like base 24 of a de-agglomerator of theinhaler 10 ofFIGS. 1 and 2 andFIG. 8 shows atop piece 26 of the de-agglomerator. The cup-like base 24 is received in thelower portion 22 of thehousing 18 and thedose magazine 12 is received for rotation over thetop piece 26 of the de-agglomerator and guided by theupper portion 20 of thehousing 18. - During operation, the
magazine 12 is movable with respect to theupper portion 20 of thehousing 18 for sequentiallypositioning reservoirs 30 of themagazine 12 within adelivery passageway 32 of the upper portion. Then, a breath-induced low pressure at an outlet port 34 (shown inFIGS. 7 and 9 ) of the de-agglomerator causes an air flow, through the drypowder delivery passageway 32 into a dry powder supply port 36 (shown inFIG. 8 ) of the de-agglomerator. As shown best inFIG. 3 , thepassageway 32 of theupper portion 20 includes a venturi (or venturi-type restriction) that causes the velocity of the breath-induced air flow to increase. The air pressure in the venturi decreases as a result of the increased velocity, and the drop in pressure causes the pre-metered dose of dry powder to be dragged from thereservoir 30 aligned with thepassageway 32, and entrained into the air flow traveling to the de-agglomerator. - Preferably, the
magazine 12 is movable with respect to theupper portion 20 of the housing for sequentially positioning thedry powder reservoirs 30 of the magazine within thedelivery passageway 32 of the upper portion. However, it should be understood that themagazine 12 could be made stationary, and theupper portion 20 made movable with respect to the magazine for sequentially positioning the passageway over the reservoirs. - The
magazine 12 is provided with an annular shape such that rotation of the annular magazine sequentially positions the plurality of thedry powder reservoirs 30 within thedelivery passageway 32 of theupper portion 20 of thehousing 18. Theannular magazine 12 includesteeth 40 extending radially outwardly that are engaged by apivotal rake 42 of themouthpiece cover 14 for advancing themagazine 12 upon thecover 14 being opened.FIGS. 10 and 11 show themagazine advancement rake 42 pivotally extending from thecover 14. Theengagement rake 42 engages theteeth 40 of themagazine 12 to rotate and advance themagazine 12 upon themouthpiece cover 14 being opened. - The
dry powder reservoirs 30 are provided in the top surface of themagazine 12 and are uniformly sized and spaced with respect to one another. Themagazine 12 preferably includes a seal over the top surface for sealing the doses of dry powder in thereservoirs 30 of the magazine in a moisture resistant and airtight manner prior to the reservoirs being positioned within thedelivery passageway 32 of theupper portion 20. The seal can comprise, for example, a metal foil secured to the annular top surface of themagazine 12 with adhesive and covering the dry powder in thereservoirs 30 in a moisture resistant and airtight manner. Theupper portion 20 of thehousing 18 can include means for piercing the foil above each of thereservoirs 30 prior to the reservoirs being positioned within thedelivery passageway 32 of the upper portion. The means for piercing can comprise, for example, a blade extending downward from theupper portion 20 of thehousing 18 in front of the venturi of thedelivery passageway 32. - It is intended that a manufacturer will fill the
reservoirs 30 of themagazine 12 with properly metered individual doses of dry powder medicament, or a medicament composition including medicament and a suitable particulate carrier such as lactose. The filledreservoirs 30 are then sealed in a moisture resistant and airtight manner, with the foil for example, and themagazine 12 and theupper portion 20 of thehousing 18 are provided assembled as part of theinhaler 10. Theinhaler 10 and themagazine 12 may be disposable. Alternatively, thedose magazine 12 may be removably insertable into anon-disposable inhaler 10 so that an empty magazine can be replaced by a full magazine. - Preferably, the
magazine 12 is movable with respect to theupper portion 20 of thehousing 18 through a plurality of discrete increments, wherein at each increment one of the plurality of thedry powder reservoirs 30 of the magazine is positioned within thedelivery passageway 32 of the upper portion. In addition, themagazine 12 is preferably movable in a single direction only with respect to thehousing 18, so that a user can access thereservoirs 30 in sequence, without being able to access one of thereservoirs 30 more than once. Furthermore, movement between themagazine 12 and theupper portion 20 of the housing is preferably prevented after all thedry powder reservoirs 30 of the magazine have been positioned in thedelivery passageway 32 of the upper portion, to provide an indication to a patient that all of the doses of the magazine have been used. For example, themagazine 12 is provided with a radially inwardly extendingcatch 44, as shown inFIG. 5 , that prevents further rotation of the magazine upon all of thereservoirs 30 passing through thedelivery passageway 32 of thehousing 18. - The
inhaler 10 can also include an indicator for indicating the number ofdry powder reservoirs 30 containing dry powder, i.e., the number of pre-metered doses remaining in themagazine 12. The indicator can comprise, for example, sequential printed numbers corresponding to thereservoirs 30 of themagazine 12 provided on the outer surface of the magazine, so that the number of reservoirs that have passed through thedelivery passageway 32 of theupper portion 20 of thehousing 18 can be determined by partly opening the cover 14 (without causing the magazine to advance) and viewing the numbers on the magazine. Although not shown, the inhaler can also be provided with a lock for locking themouthpiece cover 14 in an opened or closed position upon the advancement of a final medicament reservoir of the magazine. - As its name implies, the de-agglomerator breaks down agglomerates of dry powder before inhalation of the dry powder by a patient. The de-agglomerator includes two diametrically
opposed inlet ports 46 that extend in a direction substantially tangential to the circular cross-section of the swirl chamber formed within the de-agglomerator. As a result, air flows entering the chamber through theinlet ports 46 are at least initially directed transverse with respect to the chamber and collide with the air flow entering through the supply port to create a combined turbulent air flow. - The de-agglomerator includes
vanes 48 at the first end of theswirl chamber 52. Thevanes 48 are sized such that at least a portion of the combined air flows collide with oblique surfaces of the vanes. The geometry of theswirl chamber 52 causes the combined air flows and the entrained dry powder to follow a turbulent spiral path, or vortex, through the chamber. Thus, particles and any agglomerates of the dry powder constantly impact against the wall of the swirl chamber and collide with each other, resulting in a mutual grinding or shattering action between the particles and agglomerates. In addition, particles and agglomerates deflected off the oblique surfaces of thevanes 48 cause further impacts and collisions. The constant impacts and collisions cause any agglomerates of dry powder to break into additional particles, and cause the particles to be substantially micronized. - Upon exiting the
swirl chamber 52, the direction of the combined air flow and the entrained dry powder is again changed through theoutlet port 34, which extends through themouthpiece 16 of thehousing 18. The combined air flow and the entrained dry powder retain a swirl component of the flow, such that the air flow and the entrained dry powder spirally swirl through theoutlet port 34. Since the micronized powder and any remaining agglomerates maintain the swirl imparted from the swirl chamber, the swirling flow causes additional impacts in theoutlet port 34 so as to result in further breaking up of any remaining agglomerates prior to being inhaled by a patient. The de-agglomerator, therefore, ensures that particles of the dry powder are small enough for adequate penetration of the powder into a bronchial region of a patient's lungs during inhalation. - The de-agglomerator is assembled from two pieces: the cup-
like base 24 shown inFIGS. 7 and 9 , and thetop piece 26 shown inFIG. 8 , which are connected together to form theswirl chamber 52 within the de-agglomerator. The cup-like base 24 is secured in thelower portion 22 of thehousing 18 and defines theoutlet port 34 and theinlet ports 46. Thetop piece 26 forms thevanes 48 and defines thesupply port 36. - The
top piece 26 also includes an upwardly extendingcylindrical guide 50, and a chimney (not viewable) extending upwardly from thesupply port 36 within the guide, as shown best inFIG. 8 . The inner circumference of theannular magazine 12 is received coaxially on theguide 50, such that the magazine can be rotated about the guide. A hood of theupper portion 20 of thehousing 18 is received over the chimney of thesupply port 36 to connect thedelivery passageway 32 of theupper portion 30 with thesupply port 36 of the de-agglomerator. - The de-agglomerator, the magazine and the housing are preferably manufactured from a plastic such as polypropylene, acetal or moulded polystyrene, but may be manufactured from metal or another suitable material.
- The inhaler of
FIGS. 1 through 11 may be used for any drug formulation which may be advantageously administered to the lung or nasal passages in an animal, to cure or alleviate any illness or its symptoms. Many medicaments, bioactive active substances and pharmaceutical compositions may be included in the dosage forms of the present invention. Non-limiting examples of classes of drugs contemplated for use include ace-inhibitors, acne drugs, alkaloids, amino acid preparations, anabolic preparations, analgesics, anesthetics, antacids, antianginal drugs, anti-anxiety agents, anti-arrhythmias, anti-asthmatics, antibiotics, anti-cholesterolemics, anti-coagulants, anti-convulsants, anti-depressants, anti-diabetic agents, anti-diarrhea preparations, antidotes, anti-emetics, anti-histamines, anti-hypertensive drugs, anti-inflammatory agents, anti-lipid agents, anti-manics, anti-nauseants, anti-neoplastics, anti-obesity drugs, anti-parkinsonism agents, anti-psychotics, anti-pyretics, anti-rheumatic agents, anti-spasmodics, anti-stroke agents, anti-thrombotic drugs, anti-thyroid preparations, anti-tumor drugs, anti-tussives, anti-ulcer agents, anti-uricemic drugs, anti-viral drugs, appetite stimulants or suppressants, biological response modifiers, blood modifiers, bone metabolism regulators, cardiovascular agents, central nervous system stimulates, cerebral dilators, cholinesterase inhibitors, contraceptives, coronary dilators, cough suppressants, decongestants, dietary supplements, diuretics, DNA and genetic modifying drugs, dopamine receptor agonists, endometriosis management agents, enzymes, erectile dysfunction therapies, erythropoietic drugs, expectorants, fertility agents, gastrointestinal agents, homeopathic remedies, hormones, hyper- and hypo-glycemic agents, hypercalcemia and hypocalcemia management agents, hypnotics, immunomodulators, immunosuppressives, ion exchange resins, laxatives, migraine preparations, motion sickness treatments, mucolytics, muscle relaxants, neuromuscular drugs, obesity management agents, osteoporosis preparations, oxytocics, parasympatholytics, parasympathomimetics, peripheral vasodilators, prostaglandins, psychotherapeutic agents, psycho-tropics, stimulants, respiratory agents, sedatives, smoking cessation aids, sympatholytics, systemic and non-systemic anti-infective agents, terine relaxants, thyroid and anti-thyroid preparations, tranquilizers, tremor preparations, urinary tract agents, vasoconstrictors, vasodilators, and combinations thereof. - In some embodiments of the invention, the dosage form for use with the invention comprises anti-inflammatory agents suitable for inhalation administration. Such anti-inflammatory agents may include, for example, bronchodilators and steroids. Representative β2-adrenergic receptor agonist bronchodilators include, without limitation, salmeterol, formoterol, bambuterol, albuterol, terbutaline, pirbuterol, bitolterol, metaproterenol, isoetharine, isoproterenol, fenoterol, or procaterol. Non-limitating anti-inflammatory steroids contemplated for use with the invention include budesonide, beclomethasone, fluticasone, and triamcinolone diacetate. Additional anti-inflammatory agents contemplated include ipatropium bromide and sodium cromoglycate.
- Therapeutically effective formulations and dosages to be administered using the devices described herein are well known to practitioners. One of skill in the art will appreciate that practitioners may opt to alter dosages and/or formulations to fit a particular patient/animal need.
-
FIGS. 12 through 14 show an exemplary embodiment of adose magazine 60 constructed in accordance with the present disclosure. Thedose magazine 60 can be used, for example, with the inhaler ofFIGS. 1 through 11 . As shown inFIG. 14 , thedose magazine 60 includes medicament reservoirs in the form ofaxial bores 62 for receiving medicament. As shown inFIGS. 12 and 13 , thedose magazine 60 also includes alower layer 64 of moisture resistant, air-tight material covering a lower surface of the magazine and anupper layer 66 of moisture resistant, air-tight material covering an upper surface of the magazine and enclosing medicament in thebores 62 of the magazine in a dry, air-tight manner. As shown best inFIG. 13 , theupper layer 66 of moisture resistant, air-tight material can be provided withdomes 68 over the medicament bores 62 so that ablade 70 can be positioned to successively cut open thedomes 68 and release the medicament upon rotation of themagazine 60. - The moisture resistant, air-tight material can comprise, for example, metal foil secured to the magazine with adhesive. In addition, the foil layers may include selective adhesive, e.g., no adhesive positioned in contact with the medicament, in order to maintain dose uniformity. The moisture resistant, air-tight material can also comprise, for example, a laminate of metal foil secured to a layer of plastic, which in turn is secured to the magazine with adhesive.
-
FIGS. 15 and 16 show another exemplary embodiment of adose magazine 80 constructed in accordance with the present disclosure. As shown, themagazine 80 includesmedicament reservoirs 82 and each medicament reservoir includes a lining 84 of moisture resistant, air-tight material, such as a metal insert or foil. -
FIGS. 17 and 18 show an additional exemplary embodiment of adose magazine 90 constructed in accordance with the present disclosure. As shown, themagazine 90 includesmedicament reservoirs 92 formed in atrough 94 of a first material, such as plastic, which is formed in atrough 96 of moisture resistant, air-tight material, such as a metal. Themetal trough 96 can be pre-formed via stamping or metal injection molding. Themetal trough 96 can also be formed from a metal foil. -
FIG. 19 shows a further exemplary embodiment of adose magazine 100 constructed in accordance with the present disclosure, and including afoil removal mechanism 102. The foil removal mechanism comprises a rotatable windingwheel 102 which peels anupper layer 104 of moisture resistant, air-tight material, such as metal foil, from an upper surface of themagazine 100 as the magazine is rotated. As thefoil 104 is peeled from themagazine 100,medicament reservoirs 106 are uncovered to allow inhalation of the medicament therein. Thefoil removal mechanism 102 can also be adapted and used to index themagazine 100. -
FIGS. 20 and 21 show a further exemplary embodiment of adose magazine 110 constructed in accordance with the present disclosure. Thedose magazine 110 includesaxial bores 112 containingdeployable medicament pistons 114 sealed betweenlayers pistons 114 each have at least onecompartment 120 holding at least one dose of powder medicament, which are presented for inhalation upon thepistons 114 being pushed upwardly through theupper layer 116 of foil. -
FIG. 22 shows exemplary embodiments of adose magazine 130, amedicament piston 132, and anactuator 134, which is shown deploying the piston, all constructed in accordance with the present disclosure.FIG. 23 is a perspective view of theactuator 134 ofFIG. 22 . As themagazine 130 is linearly moved over theactuator 134, theactuator 134 successively pushes thepistons 132 upwardly through theupper layer 116 of foil to expose acompartment 136 containing a dose of medicament for inhalation. -
FIGS. 24 and 25 show additional exemplary embodiments of adose magazine 140, amouthpiece cover 142 and anactuator 144, all constructed in accordance with the present disclosure, and wherein theactuator 144 is adapted to cause amedicament piston 146 to be deployed from themagazine 140 upon themouthpiece cover 142 being opened. -
FIG. 26 shows a further exemplary embodiment of adose magazine 150, amedicament piston 152, and anactuator 154 shown deploying the piston, all constructed in accordance with the present disclosure. Themedicament piston 152 includes multiple, vertically arranged compartments in the form ofshoulders piston 152 is extended through theupper layer 116 of foil, the amount of medicament for inhalation can be varied. For example, thepiston 152 can be extended through thefoil 116 so that only oneshoulder 156 a out of the threeshoulders piston 152 can be extended through thefoil 116 so that all of theshoulders -
FIGS. 27 through 30 show various exemplary embodiments ofmedicament pistons piston 160 ofFIG. 27 includes vertically arrangedshoulders shoulders piston 160. Thepiston 162 ofFIG. 28 includes vertically arrangedcompartments compartments piston 164 ofFIG. 29 includes vertically arrangedshoulders 172 for holding dry powder medicament, and the shoulders are equally sized. Thepiston 166 ofFIG. 30 includes vertically arrangedcompartments 174 for holding dry powder medicament, and the compartments are equally sized. -
FIGS. 31 through 38 show further exemplary embodiments ofmedicament pistons piston 180 ofFIGS. 31 and 32 has a circular cross-section and includes asingle compartment 190 for holding dry powder medicament. Thepiston 182 ofFIGS. 33 and 34 has a circular cross-section and includes vertically arrangedshoulders 192 for holding dry powder medicament, and theshoulders 192 are equally sized. Thepiston 184 ofFIGS. 35 and 36 has a rectangular cross-section and includes asingle compartment 194 for holding dry powder medicament. Thepiston 186 ofFIGS. 37 and 38 has a rectangular cross-section and includes vertically arrangedcompartments 196 for holding dry powder medicament, and thecompartments 196 are equally sized. -
FIG. 39 is a top perspective view of a further exemplary embodiment of adose magazine 200 constructed in accordance with the present disclosure. Thedose magazine 200 includes examples of variously shaped and arranged bores for receiving deployable medicament pistons, such as the medicament pistons ofFIGS. 27 through 38 , for example. Themagazine 200 can include, for example,circular bores 202 that extend radially through the magazine orcircular bores 204 that extend axially through the magazine. Themagazine 200 can also includerectangular bores 206 that extend radially through the magazine orrectangular bores 208 that extend axially through the magazine. In addition, themagazine 200 can include aset 210 of radially arranged, rectangular bores or aset 212 of radially extending, rectangular bores. -
FIG. 40 shows exemplary embodiments of adose magazine 220, anactuator 222 for causing deployment of amedicament piston 224 from the magazine, and anadjustment mechanism 226 for adjusting the magnitude of deployment produced by the actuator, all constructed in accordance with the present disclosure. Theadjustment mechanism 226 can be adjusted by a user to adjust the magnitude of deployment of thepiston 224 produced by theactuator 222, so that the amount of dry powder medicament exposed for inhalation can be adjusted. Theadjustment mechanism 226 includesshims 228 which prevent full motion ofactuator 222, and a user can dial in the number ofshims 228 corresponding to a desired dose. -
FIG. 41 is a top plan view of a further exemplary embodiment of adose magazine 230 constructed in accordance with the present disclosure and includingsets 232 of deployable medicament pistons, andFIG. 42 is a side perspective view of a portion of thedose magazine 230 ofFIG. 41 , wherein aset 232 of themedicament pistons FIGS. 43 and 44 show aset 236 ofactuators set 232 of themedicament pistons actuators pistons -
FIGS. 45 and 46 show a further exemplary embodiment of adose magazine 240 constructed in accordance with the present disclosure and includingbores 242 for receiving deployable medicament pistons. Thebores 242 extend radially with respect to an axis A of themagazine 240. -
FIGS. 47 and 48 show another exemplary embodiment of adose magazine 250 constructed in accordance with the present disclosure and includingbores 252 for receiving deployable medicament pistons. Thebores 252 extend radially and at an angle with respect to an axis A of themagazine 250. -
FIG. 49 shows an additional exemplary embodiment of adose magazine 260 constructed in accordance with the present disclosure and includingbores 262 for receiving deployable medicament pistons. Thebores 262 extend tangentially with respect to themagazine 260. -
FIG. 50 shows a further exemplary embodiment of adose magazine 270 constructed in accordance with the present disclosure and includingbores 272 for receiving deployable medicament pistons. Thebores 272 are positioned at an outer circumference of themagazine 270 and extend axially with respect to an axis A of the magazine. -
FIG. 51 shows a further exemplary embodiment of arotatable dose magazine 280 constructed in accordance with the present disclosure and including radially extendingteeth 282 for engaging apawl 284, as shown, to prevent reverse rotation of themagazine 280 and to provide an indication of the advancement of afinal medicament reservoir 286 of the magazine. This mechanism can be used to increase the force required to advance themagazine 280, increase noise or vibration, or provide other indication that thelast medicament reservoir 286 is approaching and the inhaler should be refilled or replaced. -
FIGS. 52 and 53 show an exemplary embodiment of apawl 294 constructed in accordance with the present disclosure, for engaging adose magazine 290. Thepawl 294 can be adapted to provide a different sounding noise upon the advancement of afinal medicament reservoir 296 and extendingtooth 292 of themagazine 290. -
FIG. 54 shows another exemplary embodiment of arotatable dose magazine 300 constructed in accordance with the present disclosure and including radially extendingmedicament dose containers 302 and a fixedblade 304 for successively opening the dose containers upon rotation of the magazine. -
FIG. 55 shows an exemplary embodiment of adose magazine 310 constructed in accordance with the present disclosure and includingmedicament dose containers 312, and wherein an exemplary embodiment of ablade 314 constructed in accordance with the present disclosure for successively opening thedose containers 312 upon linear movement of themagazine 310 is shown. -
FIG. 56 shows another exemplary embodiment of adose magazine 320 constructed in accordance with the present disclosure and includingmedicament dose containers 322, and whereinparallel layers dose magazine 320 and successive opening of thedose containers 322 contained between thelayers -
FIG. 57 shows an exemplary embodiment of amedicament dose magazine 330 constructed in accordance with the present disclosure and havingdoses 332 of medicament attached to a surface of themagazine 330. Themagazine 330 is made of elastic material and is drawn around asharp corner 334 to successively release thedoses 332 of the medicament from themagazine 330 as the magazine is bent around thecorner 334. -
FIG. 58 shows a further exemplary embodiment of adose magazine 340 constructed in accordance with the present disclosure and includingmedicament dose containers 342. Thedose magazine 340 is drawn around asharp corner 344 to successively open thedose containers 342 as the containers are bent around the corner. - It should be understood that the foregoing detailed description and exemplary embodiments are only illustrative of a dry powder medicament inhaler and elements thereof according to the present disclosure. Various alternatives and modifications to the presently disclosed inhaler and inhaler elements can be devised by those skilled in the art without departing from the spirit and scope of the present disclosure. Accordingly, the present disclosure is intended to embrace all such alternatives and modifications that fall within the spirit and scope of the present disclosure and the following claims.
Claims (53)
1. (canceled)
2. (canceled)
3. (canceled)
4. (canceled)
5. (canceled)
6. (canceled)
7. (canceled)
8. (canceled)
9. (canceled)
10. (canceled)
11. (canceled)
12. (canceled)
13. (canceled)
14. (canceled)
15. (canceled)
16. (canceled)
17. (canceled)
18. (canceled)
19. (canceled)
20. (canceled)
21. (canceled)
22. (canceled)
23. (canceled)
24. (canceled)
25. (canceled)
26. (canceled)
27. (canceled)
28. (canceled)
29. (canceled)
30. (canceled)
31. (canceled)
32. (canceled)
33. (canceled)
34. (canceled)
35. (canceled)
36. (canceled)
37. A dry powder inhaler, comprising:
a housing having a mouthpiece and a delivery passageway connected to the mouthpiece;
a magazine positioned within the housing and including a plurality of reservoirs for holding doses of dry powder, the magazine being movable within the housing to sequentially position the reservoirs within the delivery passageway, the magazine including a layer of moisture resistant, air-tight material secured to an upper surface of the magazine over the reservoirs;
a de-agglomerator positioned between the magazine and the mouthpiece for creating turbulent airflow;
a cover connected to the housing and selectively movable to open and close access to the mouthpiece;
a rake connected to the cover and extending into the housing, the rake being engageable with the magazine so that, upon movement of the cover to open access to the mouthpiece, the rake moves the magazine and causes one of the reservoirs to be positioned within the delivery passageway; and
a foil removal mechanism having a rotatable winding wheel that peels the layer of moisture resistant, air-tight material from the upper surface of the magazine as the magazine is moved.
38. A dry powder inhaler, comprising:
a housing having a mouthpiece and a delivery passageway connected to the mouthpiece;
a magazine positioned within the housing and including a plurality of reservoirs adapted to hold doses of dry powder, the magazine being movable within the housing to sequentially position the reservoirs within the delivery passageway;
a cover connected to the housing and selectively movable to open and close access to the mouthpiece; and
a rake connected to the cover and extending into the housing, the rake being engageable with the magazine so that, upon movement of the cover to open access to the mouthpiece, the rake moves the magazine and causes one of the reservoirs to be positioned within the delivery passageway;
wherein the magazine includes a pair of continuous strips of material which define the plurality of reservoirs, the strips being separable from one another so as to open the reservoir positioned within the delivery passageway.
39. An inhaler according to claim 38 , wherein each strip is wound on a post following separation.
40. An inhaler according to claim 38 , further comprising a de-agglomerator positioned between the magazine and the mouthpiece for creating turbulent airflow.
41. An inhaler according to claim 38 , wherein the magazine is rotatably movable with respect to the housing in only a single direction.
42. An inhaler according to claim 38 , further comprising an indicator for indicating the number of reservoirs containing dry powder remaining in the magazine.
43. An inhaler according to claim 38 , further comprising dry powder medicament contained in the reservoirs of the magazine.
44. An inhaler according to claim 38 , wherein the strips are formed from a moisture resistant, air-tight material.
45. An inhaler according to claim 38 , further comprising means for determining when a last one of the reservoirs has been positioned within the delivery passageway.
46. A dry powder inhaler, comprising:
a housing having a mouthpiece and a delivery passageway connected to the mouthpiece;
a strip of material positioned within the housing and defining a plurality of reservoirs adapted to hold doses of dry powder, the strip of material being movable within the housing to sequentially position the reservoirs within the delivery passageway;
a cover connected to the housing and selectively movable to open and close access to the mouthpiece; and
a rake connected to the cover and extending into the housing, the rake being engageable with the strip of material so that, upon movement of the cover to open access to the mouthpiece, the rake moves the strip of material and causes one of the reservoirs to be positioned within the delivery passageway; and
means for opening the reservoir positioned within the delivery passageway to release a dose of dry powder.
47. An inhaler according to claim 46 , wherein the means for opening the reservoir separates a first portion of the strip of material from a second portion of the strip of material.
48. An inhaler according to claim 47 , further comprising a first post for winding the first portion of the strip of material and a second post for winding the second portion of the strip of material.
49. An inhaler according to claim 46 , further comprising a de-agglomerator positioned between the strip of material and the mouthpiece for creating turbulent airflow.
50. An inhaler according to claim 46 , wherein the strip of material is rotatably movable with respect to the housing in only a single direction.
51. An inhaler according to claim 46 , further comprising an indicator for indicating the number of reservoirs containing dry powder remaining in the strip of material.
52. An inhaler according to claim 46 , further comprising dry powder medicament contained in the reservoirs in the strip of material.
53. An inhaler according to claim 46 , wherein the strip of material is formed from a moisture resistant, air-tight material.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/321,209 US20090205657A1 (en) | 2003-02-20 | 2009-01-16 | Pre-metered dose magazine for dry powder inhaler |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0303870.0 | 2003-02-20 | ||
GBGB0303870.0A GB0303870D0 (en) | 2003-02-20 | 2003-02-20 | Pre-metered dose magazine for breath-actuated dry powder inhaler |
US10/783,796 US7503324B2 (en) | 2003-02-20 | 2004-02-20 | Pre-metered dose magazine for dry powder inhaler |
US12/321,209 US20090205657A1 (en) | 2003-02-20 | 2009-01-16 | Pre-metered dose magazine for dry powder inhaler |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/783,796 Continuation US7503324B2 (en) | 2003-02-20 | 2004-02-20 | Pre-metered dose magazine for dry powder inhaler |
Publications (1)
Publication Number | Publication Date |
---|---|
US20090205657A1 true US20090205657A1 (en) | 2009-08-20 |
Family
ID=9953339
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/783,796 Expired - Fee Related US7503324B2 (en) | 2003-02-20 | 2004-02-20 | Pre-metered dose magazine for dry powder inhaler |
US12/321,209 Abandoned US20090205657A1 (en) | 2003-02-20 | 2009-01-16 | Pre-metered dose magazine for dry powder inhaler |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/783,796 Expired - Fee Related US7503324B2 (en) | 2003-02-20 | 2004-02-20 | Pre-metered dose magazine for dry powder inhaler |
Country Status (11)
Country | Link |
---|---|
US (2) | US7503324B2 (en) |
EP (1) | EP1603616A2 (en) |
JP (1) | JP2006518658A (en) |
KR (1) | KR20060106627A (en) |
CN (1) | CN1816365A (en) |
AU (1) | AU2004264783A1 (en) |
BR (1) | BRPI0407731A (en) |
GB (1) | GB0303870D0 (en) |
MX (1) | MXPA05008123A (en) |
RU (1) | RU2332240C2 (en) |
WO (1) | WO2005016424A2 (en) |
Cited By (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090205656A1 (en) * | 2006-06-27 | 2009-08-20 | Otsuka Pharmaceutical Co., Ltd. | Powder inhaler |
WO2012128692A1 (en) | 2011-03-21 | 2012-09-27 | Simplified Solutions Sweden Ab | Inhalator for substances in powder form |
US8424518B2 (en) | 2008-06-13 | 2013-04-23 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
US9179691B2 (en) | 2007-12-14 | 2015-11-10 | Aerodesigns, Inc. | Delivering aerosolizable food products |
US9220687B2 (en) | 2008-12-29 | 2015-12-29 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9233159B2 (en) | 2011-10-24 | 2016-01-12 | Mannkind Corporation | Methods and compositions for treating pain |
US9241903B2 (en) | 2006-02-22 | 2016-01-26 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
US9283193B2 (en) | 2005-09-14 | 2016-03-15 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US9358352B2 (en) | 2008-06-13 | 2016-06-07 | Mannkind Corporation | Dry powder drug delivery system and methods |
US9364619B2 (en) | 2008-06-20 | 2016-06-14 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
US9364436B2 (en) | 2011-06-17 | 2016-06-14 | Mannkind Corporation | High capacity diketopiperazine microparticles and methods |
US9630930B2 (en) | 2009-06-12 | 2017-04-25 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
US9675674B2 (en) | 2004-08-23 | 2017-06-13 | Mannkind Corporation | Diketopiperazine salts for drug delivery and related methods |
US9700690B2 (en) | 2002-03-20 | 2017-07-11 | Mannkind Corporation | Inhalation apparatus |
US9706944B2 (en) | 2009-11-03 | 2017-07-18 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
US9796688B2 (en) | 2004-08-20 | 2017-10-24 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
US9801925B2 (en) | 1999-06-29 | 2017-10-31 | Mannkind Corporation | Potentiation of glucose elimination |
US9802012B2 (en) | 2012-07-12 | 2017-10-31 | Mannkind Corporation | Dry powder drug delivery system and methods |
US9925144B2 (en) | 2013-07-18 | 2018-03-27 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
US9943571B2 (en) | 2008-08-11 | 2018-04-17 | Mannkind Corporation | Use of ultrarapid acting insulin |
US9983108B2 (en) | 2009-03-11 | 2018-05-29 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10421729B2 (en) | 2013-03-15 | 2019-09-24 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
US10625034B2 (en) | 2011-04-01 | 2020-04-21 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005044173A1 (en) * | 2003-10-27 | 2005-05-19 | Oriel Therapeutics, Inc. | Blister packages and associated methods of fabricating dry powder drug containment systems |
US8763605B2 (en) * | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
GB0515584D0 (en) | 2005-07-28 | 2005-09-07 | Glaxo Group Ltd | Medicament dispenser |
FR2896419B1 (en) | 2006-01-25 | 2009-02-27 | Valois Sas | ORAL TIP FOR FLUID PRODUCT DISPENSING DEVICE |
DE102006029753A1 (en) | 2006-03-10 | 2007-09-13 | Alfred Von Schuckmann | Inhaler for powdered substances |
EP1844809A1 (en) * | 2006-04-13 | 2007-10-17 | Boehringer Ingelheim Pharma GmbH & Co. KG | Container for inhaler, and multidose inhaler |
CA2886385A1 (en) * | 2007-01-09 | 2008-07-17 | Mystic Pharmaceuticals, Inc. | Intranasal cartridge devices |
DE102007026752A1 (en) * | 2007-06-09 | 2008-12-11 | Ivonne Silvester | Device for storage and administration of active ingredients |
US11224704B2 (en) | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
JP5528336B2 (en) | 2007-07-06 | 2014-06-25 | マンタ デバイシス,エルエルシー | Delivery device and related method |
CA2732842C (en) | 2008-09-26 | 2018-01-09 | Oriel Therapeutics, Inc. | Inhalers with airway disks having discrete airway channels and related disks and methods |
EP2346554B1 (en) * | 2008-09-26 | 2015-09-16 | Oriel Therapeutics, Inc. | Inhaler mechanisms with radially biased piercers and related methods |
CN102159269B (en) | 2008-09-26 | 2014-05-07 | 奥里尔治疗公司 | Dry powder inhalers with dual piercing members and related devices and methods |
WO2010039201A2 (en) * | 2008-09-30 | 2010-04-08 | Oriel Therapeutics, Inc. | Dry powder inhalers with multi-facet surface deagglomeration chambers and related devices and methods |
US8646446B2 (en) * | 2008-10-01 | 2014-02-11 | Oriel Therapeutics, Inc. | Dry powder inhalers with rotating piercing mechanisms and related devices and methods |
GB201020130D0 (en) | 2010-11-26 | 2011-01-12 | Vectura Delivery Devices Ltd | Inhaler |
US8919341B2 (en) | 2008-12-03 | 2014-12-30 | Boehringer Ingelheim International Gmbh | Inhaler |
SI2239002T1 (en) * | 2009-03-30 | 2013-10-30 | Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi | Dry powder inhaler device and lock mechanism |
GB0919465D0 (en) * | 2009-11-06 | 2009-12-23 | Norton Healthcare Ltd | Airflow adaptor for a breath-actuated dry powder inhaler |
MY187036A (en) * | 2010-01-05 | 2021-08-27 | Microdose Therapeutx Inc | Inhalation device and method |
USD641076S1 (en) | 2010-03-26 | 2011-07-05 | Oriel Therapeutics, Inc. | Dry powder inhaler |
USD635246S1 (en) | 2010-03-26 | 2011-03-29 | Oriel Therapeutics, Inc. | Dose disk for dry powder inhalers |
CA2811947C (en) * | 2010-09-30 | 2019-07-23 | Novartis Ag | Inhaler |
JP6506257B2 (en) * | 2013-05-17 | 2019-04-24 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Drug delivery module |
USD804015S1 (en) * | 2013-12-23 | 2017-11-28 | Glenmark Pharmaceuticals Limited | Inhaler |
WO2015168572A2 (en) | 2014-05-02 | 2015-11-05 | Manta Devices, Llc | Delivery device and related methods |
US10610512B2 (en) | 2014-06-26 | 2020-04-07 | Island Breeze Systems Ca, Llc | MDI related products and methods of use |
CA169756S (en) | 2016-02-08 | 2017-09-01 | Nicoventures Holdings Ltd | Electronic cigarette |
JP7185529B2 (en) * | 2016-02-24 | 2022-12-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | inhaler |
GB201605105D0 (en) | 2016-03-24 | 2016-05-11 | Nicoventures Holdings Ltd | Vapour provision apparatus |
GB201605102D0 (en) | 2016-03-24 | 2016-05-11 | Nicoventures Holdings Ltd | Mechanical connector for electronic vapour provision system |
GB201605101D0 (en) | 2016-03-24 | 2016-05-11 | Nicoventures Holdings Ltd | Electronic vapour provision system |
GB201605100D0 (en) | 2016-03-24 | 2016-05-11 | Nicoventures Holdings Ltd | Vapour provision system |
US11524823B2 (en) | 2016-07-22 | 2022-12-13 | Nicoventures Trading Limited | Case for a vapor provision device |
CN107174713B (en) * | 2017-04-25 | 2020-01-21 | 中国人民解放军第三军医大学第一附属医院 | Anti-overflow intelligence volatilizees jar doser |
US20190001082A1 (en) * | 2017-06-29 | 2019-01-03 | Elizabeth Tarangelo | Wearable aerosol inhaler device and method |
US20210402113A1 (en) * | 2019-01-14 | 2021-12-30 | Philip Morris Products S.A. | Dry powder inhaler |
Citations (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3530857A (en) * | 1967-12-18 | 1970-09-29 | Abbott Lab | Resuscitator mask |
US4384577A (en) * | 1981-04-03 | 1983-05-24 | Moldex/Metric Products, Inc. | Disposable face mask |
US5327883A (en) * | 1991-05-20 | 1994-07-12 | Dura Pharmaceuticals, Inc. | Apparatus for aerosolizing powdered medicine and process and using |
US5441060A (en) * | 1993-02-08 | 1995-08-15 | Duke University | Dry powder delivery system |
US5503144A (en) * | 1990-12-15 | 1996-04-02 | Norton Healthcare Limited | Powdered medicament dispensing device |
US5544646A (en) * | 1993-05-21 | 1996-08-13 | Aradigm Corporation | Systems for the intrapulmonary delivery of aerosolized aqueous formulations |
US5577497A (en) * | 1991-05-20 | 1996-11-26 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5590645A (en) * | 1990-03-02 | 1997-01-07 | Glaxo Group Limited | Inhalation device |
US5921237A (en) * | 1995-04-24 | 1999-07-13 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US6371111B1 (en) * | 1999-01-27 | 2002-04-16 | Unisia Jecs Corporation | Inhalation type drug dispenser |
US6378519B1 (en) * | 1990-03-02 | 2002-04-30 | Glaxo Group Limited | Inhalation device |
US6665381B1 (en) * | 2002-02-26 | 2003-12-16 | Shary Nassimi | Self-contained device using a single phone line to receive phone calls and facsimiles while connectable to the internet |
US6748947B2 (en) * | 2000-06-23 | 2004-06-15 | Norton Healthcare, Ltd. | De-agglomerator for breath-actuated dry powder inhaler |
US6809996B2 (en) * | 2000-06-14 | 2004-10-26 | Tdk Corporation | Optical head, optical recording/reproducing apparatus and laser module |
US6880555B1 (en) * | 1999-10-12 | 2005-04-19 | Shl Medical Ab | Inhaler |
US7093595B2 (en) * | 2001-10-08 | 2006-08-22 | Eli Lilly And Company | Portable medication inhalation kit |
US7171965B2 (en) * | 2000-02-01 | 2007-02-06 | Valois S.A.S. | Breath actuated dry powder inhaler and tape dose strip |
US20070062525A1 (en) * | 2002-01-25 | 2007-03-22 | Bonney Stanley G | Medicament dispenser |
US7231920B2 (en) * | 2000-10-31 | 2007-06-19 | Glaxo Group Limited | Medicament dispenser |
US20070272169A1 (en) * | 2003-09-18 | 2007-11-29 | Brian Barney | Drug Delivery Mask for Animals |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8909891D0 (en) * | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
FR2667509B1 (en) * | 1990-10-04 | 1995-08-25 | Valois | POWDER INHALER, DEVICE FOR PACKAGING POWDER MICRODOSES IN THE FORM OF BANDS SUITABLE FOR USE IN A POWDER INHALER, AND METHOD FOR MANUFACTURING SUCH BANDS. |
GB9203761D0 (en) * | 1992-02-21 | 1992-04-08 | Innovata Biomed Ltd | Inhaler |
GB2270293A (en) * | 1992-09-05 | 1994-03-09 | Medix Ltd | Drug dispensing system |
US5622166A (en) * | 1995-04-24 | 1997-04-22 | Dura Pharmaceuticals, Inc. | Dry powder inhaler delivery system |
GB2340758A (en) * | 1998-08-21 | 2000-03-01 | Bespak Plc | Drug dispensing system |
GB9920839D0 (en) * | 1999-09-04 | 1999-11-10 | Innovata Biomed Ltd | Inhaler |
AR028746A1 (en) * | 2000-06-23 | 2003-05-21 | Norton Health Care Ltd | DOSE CARTRIDGE PREVIOUSLY MEASURES FOR DRY POWDER INHALER OPERATED BY BREATHING, INHALER AND A METHOD OF PROVISION OF DOSE PREVIOUSLY DRY POWDER MEASURES |
GB0019715D0 (en) * | 2000-08-10 | 2000-09-27 | Pa Consulting Services | Device for delivering physiologically active agent in powdered form |
GB0120018D0 (en) * | 2001-08-16 | 2001-10-10 | Meridica Ltd | Pack containing medicament and dispensing device |
CA2460904C (en) * | 2001-09-19 | 2011-03-22 | Advent Pharmaceuticals Pty Ltd | An inhaler for delivering metered doses of powdered medicament |
GB2385020A (en) * | 2002-02-07 | 2003-08-13 | Meridica Ltd | Medicament container and method of manufacture thereof |
GB0315509D0 (en) * | 2003-07-02 | 2003-08-06 | Meridica Ltd | Dispensing device |
-
2003
- 2003-02-20 GB GBGB0303870.0A patent/GB0303870D0/en not_active Ceased
-
2004
- 2004-02-20 RU RU2005129262/14A patent/RU2332240C2/en not_active IP Right Cessation
- 2004-02-20 BR BRPI0407731-8A patent/BRPI0407731A/en not_active IP Right Cessation
- 2004-02-20 EP EP04775780A patent/EP1603616A2/en not_active Withdrawn
- 2004-02-20 JP JP2006508763A patent/JP2006518658A/en active Pending
- 2004-02-20 US US10/783,796 patent/US7503324B2/en not_active Expired - Fee Related
- 2004-02-20 KR KR1020057014608A patent/KR20060106627A/en not_active Application Discontinuation
- 2004-02-20 CN CNA2004800046940A patent/CN1816365A/en active Pending
- 2004-02-20 WO PCT/US2004/004843 patent/WO2005016424A2/en active Application Filing
- 2004-02-20 MX MXPA05008123A patent/MXPA05008123A/en active IP Right Grant
- 2004-02-20 AU AU2004264783A patent/AU2004264783A1/en not_active Abandoned
-
2009
- 2009-01-16 US US12/321,209 patent/US20090205657A1/en not_active Abandoned
Patent Citations (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3530857A (en) * | 1967-12-18 | 1970-09-29 | Abbott Lab | Resuscitator mask |
US4384577A (en) * | 1981-04-03 | 1983-05-24 | Moldex/Metric Products, Inc. | Disposable face mask |
US6032666A (en) * | 1990-03-02 | 2000-03-07 | Glaxo Group Limited | Inhalation device |
US6792945B2 (en) * | 1990-03-02 | 2004-09-21 | Glaxo Group Limited | Inhalation device |
US5590645A (en) * | 1990-03-02 | 1997-01-07 | Glaxo Group Limited | Inhalation device |
US6378519B1 (en) * | 1990-03-02 | 2002-04-30 | Glaxo Group Limited | Inhalation device |
US5860419A (en) * | 1990-03-02 | 1999-01-19 | Glaxo Group Limited | Inhalation device |
US5873360A (en) * | 1990-03-02 | 1999-02-23 | Glaxo Group Limited | Inhalation device |
US5503144A (en) * | 1990-12-15 | 1996-04-02 | Norton Healthcare Limited | Powdered medicament dispensing device |
US5327883A (en) * | 1991-05-20 | 1994-07-12 | Dura Pharmaceuticals, Inc. | Apparatus for aerosolizing powdered medicine and process and using |
US5577497A (en) * | 1991-05-20 | 1996-11-26 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5441060A (en) * | 1993-02-08 | 1995-08-15 | Duke University | Dry powder delivery system |
US5823178A (en) * | 1993-05-21 | 1998-10-20 | Aradigm Corporation | Disposable package for use in aerosolized delivery of drugs |
US5544646A (en) * | 1993-05-21 | 1996-08-13 | Aradigm Corporation | Systems for the intrapulmonary delivery of aerosolized aqueous formulations |
US6123068A (en) * | 1993-05-21 | 2000-09-26 | Aradigm Corporation | Systems for the intrapulmonary delivery of aerosolized aqueous formulations |
US6014969A (en) * | 1993-05-21 | 2000-01-18 | Aradigm Corporation | Disposable package for use in aerosolized delivery of antibiotics |
US5718222A (en) * | 1993-05-21 | 1998-02-17 | Aradigm Corporation | Disposable package for use in aerosolized delivery of drugs |
US5921237A (en) * | 1995-04-24 | 1999-07-13 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US6328034B1 (en) * | 1996-07-22 | 2001-12-11 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US6371111B1 (en) * | 1999-01-27 | 2002-04-16 | Unisia Jecs Corporation | Inhalation type drug dispenser |
US6880555B1 (en) * | 1999-10-12 | 2005-04-19 | Shl Medical Ab | Inhaler |
US7171965B2 (en) * | 2000-02-01 | 2007-02-06 | Valois S.A.S. | Breath actuated dry powder inhaler and tape dose strip |
US6809996B2 (en) * | 2000-06-14 | 2004-10-26 | Tdk Corporation | Optical head, optical recording/reproducing apparatus and laser module |
US6748947B2 (en) * | 2000-06-23 | 2004-06-15 | Norton Healthcare, Ltd. | De-agglomerator for breath-actuated dry powder inhaler |
US7231920B2 (en) * | 2000-10-31 | 2007-06-19 | Glaxo Group Limited | Medicament dispenser |
US7093595B2 (en) * | 2001-10-08 | 2006-08-22 | Eli Lilly And Company | Portable medication inhalation kit |
US20070062525A1 (en) * | 2002-01-25 | 2007-03-22 | Bonney Stanley G | Medicament dispenser |
US6665381B1 (en) * | 2002-02-26 | 2003-12-16 | Shary Nassimi | Self-contained device using a single phone line to receive phone calls and facsimiles while connectable to the internet |
US20070272169A1 (en) * | 2003-09-18 | 2007-11-29 | Brian Barney | Drug Delivery Mask for Animals |
Cited By (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9801925B2 (en) | 1999-06-29 | 2017-10-31 | Mannkind Corporation | Potentiation of glucose elimination |
US9700690B2 (en) | 2002-03-20 | 2017-07-11 | Mannkind Corporation | Inhalation apparatus |
US9796688B2 (en) | 2004-08-20 | 2017-10-24 | Mannkind Corporation | Catalysis of diketopiperazine synthesis |
US9675674B2 (en) | 2004-08-23 | 2017-06-13 | Mannkind Corporation | Diketopiperazine salts for drug delivery and related methods |
US10130685B2 (en) | 2004-08-23 | 2018-11-20 | Mannkind Corporation | Diketopiperazine salts for drug delivery and related methods |
US10143655B2 (en) | 2005-09-14 | 2018-12-04 | Mannkind Corporation | Method of drug formulation |
US9446001B2 (en) | 2005-09-14 | 2016-09-20 | Mannkind Corporation | Increasing drug affinity for crystalline microparticle surfaces |
US9717689B2 (en) | 2005-09-14 | 2017-08-01 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US9283193B2 (en) | 2005-09-14 | 2016-03-15 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
US10130581B2 (en) | 2006-02-22 | 2018-11-20 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
US9241903B2 (en) | 2006-02-22 | 2016-01-26 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
US20090205656A1 (en) * | 2006-06-27 | 2009-08-20 | Otsuka Pharmaceutical Co., Ltd. | Powder inhaler |
US8251059B2 (en) * | 2006-06-27 | 2012-08-28 | Otsuka Pharmaceutical Co., Ltd. | Powder inhaler |
US9179691B2 (en) | 2007-12-14 | 2015-11-10 | Aerodesigns, Inc. | Delivering aerosolizable food products |
US8424518B2 (en) | 2008-06-13 | 2013-04-23 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US9446133B2 (en) | 2008-06-13 | 2016-09-20 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US8912193B2 (en) | 2008-06-13 | 2014-12-16 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US8636001B2 (en) | 2008-06-13 | 2014-01-28 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US9393372B2 (en) | 2008-06-13 | 2016-07-19 | Mannkind Corporation | Dry powder drug delivery system |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
US9339615B2 (en) | 2008-06-13 | 2016-05-17 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US9511198B2 (en) | 2008-06-13 | 2016-12-06 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US9192675B2 (en) | 2008-06-13 | 2015-11-24 | Mankind Corporation | Dry powder inhaler and system for drug delivery |
US10201672B2 (en) | 2008-06-13 | 2019-02-12 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US10342938B2 (en) | 2008-06-13 | 2019-07-09 | Mannkind Corporation | Dry powder drug delivery system |
US9662461B2 (en) | 2008-06-13 | 2017-05-30 | Mannkind Corporation | Dry powder drug delivery system and methods |
US8499757B2 (en) | 2008-06-13 | 2013-08-06 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US9358352B2 (en) | 2008-06-13 | 2016-06-07 | Mannkind Corporation | Dry powder drug delivery system and methods |
US10751488B2 (en) | 2008-06-13 | 2020-08-25 | Mannkind Corporation | Dry powder inhaler and system for drug delivery |
US10675421B2 (en) | 2008-06-20 | 2020-06-09 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
US9364619B2 (en) | 2008-06-20 | 2016-06-14 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
US9943571B2 (en) | 2008-08-11 | 2018-04-17 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10172850B2 (en) | 2008-12-29 | 2019-01-08 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9655850B2 (en) | 2008-12-29 | 2017-05-23 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9220687B2 (en) | 2008-12-29 | 2015-12-29 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9983108B2 (en) | 2009-03-11 | 2018-05-29 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
US9630930B2 (en) | 2009-06-12 | 2017-04-25 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
US9706944B2 (en) | 2009-11-03 | 2017-07-18 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
WO2012128692A1 (en) | 2011-03-21 | 2012-09-27 | Simplified Solutions Sweden Ab | Inhalator for substances in powder form |
US9987440B2 (en) | 2011-03-21 | 2018-06-05 | Simplified Solutions Sweden Ab | Inhalator for substances in powder form |
US10625034B2 (en) | 2011-04-01 | 2020-04-21 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
US9364436B2 (en) | 2011-06-17 | 2016-06-14 | Mannkind Corporation | High capacity diketopiperazine microparticles and methods |
US10130709B2 (en) | 2011-06-17 | 2018-11-20 | Mannkind Corporation | High capacity diketopiperazine microparticles and methods |
US10258664B2 (en) | 2011-10-24 | 2019-04-16 | Mannkind Corporation | Methods and compositions for treating pain |
US9610351B2 (en) | 2011-10-24 | 2017-04-04 | Mannkind Corporation | Methods and compositions for treating pain |
US9233159B2 (en) | 2011-10-24 | 2016-01-12 | Mannkind Corporation | Methods and compositions for treating pain |
US9802012B2 (en) | 2012-07-12 | 2017-10-31 | Mannkind Corporation | Dry powder drug delivery system and methods |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
US10421729B2 (en) | 2013-03-15 | 2019-09-24 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
US9925144B2 (en) | 2013-07-18 | 2018-03-27 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
Also Published As
Publication number | Publication date |
---|---|
WO2005016424A3 (en) | 2005-06-23 |
CN1816365A (en) | 2006-08-09 |
RU2005129262A (en) | 2006-03-10 |
GB0303870D0 (en) | 2003-03-26 |
EP1603616A2 (en) | 2005-12-14 |
MXPA05008123A (en) | 2006-02-17 |
BRPI0407731A (en) | 2006-02-14 |
AU2004264783A1 (en) | 2005-02-24 |
US20060157053A1 (en) | 2006-07-20 |
WO2005016424A2 (en) | 2005-02-24 |
US7503324B2 (en) | 2009-03-17 |
JP2006518658A (en) | 2006-08-17 |
KR20060106627A (en) | 2006-10-12 |
RU2332240C2 (en) | 2008-08-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7503324B2 (en) | Pre-metered dose magazine for dry powder inhaler | |
AU2007214748B2 (en) | Dry powder inhaler device | |
US7032593B2 (en) | Inhalation device and method | |
JP5651233B2 (en) | Simple capsule-based inhaler | |
JP4497730B2 (en) | Powder inhaler for complex drugs | |
AU760750B2 (en) | Powder inhaler for combined medicament | |
US20090250058A1 (en) | Inhalation System and Delivery Device for the Administration of a Drug in the Form of Dry Powder | |
JP5667170B2 (en) | Dry powder inhaler | |
JP6683613B2 (en) | Dry powder inhaler | |
US5692496A (en) | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament | |
EP0601071B1 (en) | Powder dispenser | |
JP2008500851A (en) | Unit dose dry powder inhaler | |
US20200121870A1 (en) | Low-cost single use powder inhaler | |
AU5053100A (en) | Inhalation device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: NORTON HEALTHCARE LTD, UNITED KINGDOM Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:BARNEY, BRIAN;REEL/FRAME:022273/0279 Effective date: 20050502 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |