US20090054949A1 - Lead body constructions for implantable medical electrical leads - Google Patents
Lead body constructions for implantable medical electrical leads Download PDFInfo
- Publication number
- US20090054949A1 US20090054949A1 US11/843,021 US84302107A US2009054949A1 US 20090054949 A1 US20090054949 A1 US 20090054949A1 US 84302107 A US84302107 A US 84302107A US 2009054949 A1 US2009054949 A1 US 2009054949A1
- Authority
- US
- United States
- Prior art keywords
- lead
- filler
- connector
- lead body
- extending
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000010276 construction Methods 0.000 title description 15
- 239000000945 filler Substances 0.000 claims abstract description 120
- 239000004020 conductor Substances 0.000 claims abstract description 50
- 230000000638 stimulation Effects 0.000 claims description 36
- 229920006332 epoxy adhesive Polymers 0.000 claims description 27
- 239000000853 adhesive Substances 0.000 claims description 14
- 230000001070 adhesive effect Effects 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 11
- 230000008878 coupling Effects 0.000 claims description 7
- 238000010168 coupling process Methods 0.000 claims description 7
- 238000005859 coupling reaction Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 230000003014 reinforcing effect Effects 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 6
- 239000013464 silicone adhesive Substances 0.000 claims description 3
- 238000003780 insertion Methods 0.000 description 4
- 230000037431 insertion Effects 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 229920002313 fluoropolymer Polymers 0.000 description 3
- 239000004811 fluoropolymer Substances 0.000 description 3
- 229920001296 polysiloxane Polymers 0.000 description 3
- 229920002635 polyurethane Polymers 0.000 description 3
- 239000004814 polyurethane Substances 0.000 description 3
- 239000004642 Polyimide Substances 0.000 description 2
- 230000000747 cardiac effect Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 229920000840 ethylene tetrafluoroethylene copolymer Polymers 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000013011 mating Effects 0.000 description 2
- 229920002529 medical grade silicone Polymers 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 239000004945 silicone rubber Substances 0.000 description 2
- 125000006850 spacer group Chemical group 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 208000020446 Cardiac disease Diseases 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000000712 assembly Effects 0.000 description 1
- 238000000429 assembly Methods 0.000 description 1
- 210000005013 brain tissue Anatomy 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
- QHSJIZLJUFMIFP-UHFFFAOYSA-N ethene;1,1,2,2-tetrafluoroethene Chemical group C=C.FC(F)=C(F)F QHSJIZLJUFMIFP-UHFFFAOYSA-N 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 230000004007 neuromodulation Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000000278 spinal cord Anatomy 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R24/00—Two-part coupling devices, or either of their cooperating parts, characterised by their overall structure
- H01R24/58—Contacts spaced along longitudinal axis of engagement
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01B—CABLES; CONDUCTORS; INSULATORS; SELECTION OF MATERIALS FOR THEIR CONDUCTIVE, INSULATING OR DIELECTRIC PROPERTIES
- H01B7/00—Insulated conductors or cables characterised by their form
- H01B7/17—Protection against damage caused by external factors, e.g. sheaths or armouring
- H01B7/18—Protection against damage caused by wear, mechanical force or pressure; Sheaths; Armouring
- H01B7/1895—Internal space filling-up means
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R2107/00—Four or more poles
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01R—ELECTRICALLY-CONDUCTIVE CONNECTIONS; STRUCTURAL ASSOCIATIONS OF A PLURALITY OF MUTUALLY-INSULATED ELECTRICAL CONNECTING ELEMENTS; COUPLING DEVICES; CURRENT COLLECTORS
- H01R2201/00—Connectors or connections adapted for particular applications
- H01R2201/12—Connectors or connections adapted for particular applications for medicine and surgery
Definitions
- the present disclosure pertains to implantable medical systems and more particularly to lead body constructions for implantable medical electrical leads.
- the medical device industry produces a variety of implantable medical device systems that provide electrical stimulation therapy to patients suffering from cardiac and/or neurological disorders.
- implantable systems include those providing cardiac pacing and/or defibrillation, and those providing neuromodulation.
- Electrical stimulation is typically delivered through one or more electrodes of a stimulation lead, implanted in intimate contact with tissue at specific sites, for example, in contact with myocardial, spinal cord, peripheral nerve, or brain tissue; the one or more electrodes are coupled to a stimulation source, or device, which is implanted in a subcutaneous pocket, by corresponding isolated conductors that extend, within an elongate insulative lead body, from the device, in the pocket, to the electrodes, at the stimulation site.
- the conductors are typically coupled to the device via a connector terminal, which is designed for reversible connection within a connector port of the device and that extends proximally from a proximal end of the elongate lead body.
- elongate insulative lead bodies are designed to have a sufficient length, flexibility and durability to be routed through and/or around anatomical structures, between the pocket and the stimulation site, and to protect and isolate the conductors and electrodes of the lead from one another and from the implant environment.
- another lead including an additional set of conductors, an associated lead body, a connector port, and a connector terminal, is included in the system, either to extend a length of the stimulation lead, or to convert the connector of the stimulation lead to another type of connector, which is compatible with a particular type of device connector port.
- Lead connector terminals are typically coupled to device connector ports, as well as to connector ports of other leads, by grasping the associated lead body in proximity to the connector terminal and inserting the connector terminal into the port.
- FIG. 1 is a plan view of an exemplary system which may employ embodiments of the present disclosure.
- FIG. 2 is a cross-section perspective view of a lead body construction, according to a first group of embodiments.
- FIG. 3 is a cross-section perspective view of a lead body construction, according to a second group of embodiments.
- FIG. 4A is an exploded plan view of a portion of a lead assembly, according to some embodiments.
- FIG. 4B is an end view of a connector terminal subassembly of the lead assembly shown in FIG. 4A , according to some embodiments.
- FIG. 5 is a perspective view of a filler component, according to some embodiments.
- FIG. 6 is a cross-section perspective view of a lead body construction, according to a third group of embodiments.
- FIG. 1 is a plan view of an exemplary implantable medical electrical system which may employ embodiments of the present disclosure.
- FIG. 1 illustrates the system including an implantable medical device 10 , and a lead system formed by an adapter lead 100 and a stimulation lead 110 .
- Adapter lead 100 may be employed to extend a length of lead 110 and/or to convert a connector terminal 114 of lead 110 to a different connector terminal 102 for compatibility with a connector port (not shown) of a connector module 12 of device 10 .
- connector module 12 contains electrical contacts, within the port thereof, which are adapted to mate with individual connector elements 106 of connector terminal 102 , and/or with individual connector elements 117 of connector terminal 114 (if terminal 114 is compatible with the device connector port), and that hermitically sealed feedthrough assemblies couple each of the electrical contacts of connector module 12 with a power supply and electronic circuitry contained within a housing 15 of device 10 .
- connector elements 106 , of connector terminal 102 are isolated from one another by insulative spacers extending therebetween; likewise, connector elements 117 , of connector terminal 114 , are isolated from one another by corresponding insulative spacers.
- connector terminals 102 and 114 which is generally known to those skilled in the art, is employed by some embodiments of the present disclosure, the invention is not so limited, and alternate embodiments may include any other type of connector terminal configuration.
- FIG. 1 further illustrates stimulation lead 110 and adapter lead 100 each including an elongate insulative lead body 111 and 101 , respectively; stimulation lead body 111 includes a proximal end 113 , from which connector terminal 114 extends, and a distal end 115 , from which an electrode array 116 extends; and adapter lead body 101 includes a proximal end 103 , from which connector terminal 102 extends, and a distal end 105 , from which a connector port 104 extends.
- Electrode array 116 is shown including a plurality of electrodes 118 , which are isolated from one another, being mounted on an insulative member 119 ; each electrode 118 is coupled to a corresponding connector element 117 , via a corresponding isolated conductor 215 ( FIGS. 2-3 ) that extends within lead body 111 , between proximal end 113 and distal end 115 .
- Connector port 104 is shown extending within an insulative housing 108 and including a plurality of electrical contacts 107 , which are isolated from one another, for example, by internal sealing rings, which are known to those skilled in the art; each contact 107 is coupled to a corresponding connector element 106 , via a corresponding isolated conductor 215 that extends within lead body 101 , between proximal end 103 and distal end 105 .
- Any suitable components and construction methods which are known to those skilled in the art, may be employed to manufacture electrode array 116 , connector terminals 102 , 114 , and connector port 104 and to couple these elements to the ends of the corresponding lead body; some exemplary construction methods will be described, below, in conjunction with FIGS. 4A-B , for connector terminals 102 , 114 , according to some embodiments of the invention.
- connector terminal 102 of adapter lead 100 may be inserted, per arrow I, into the port of module 12 for electrical coupling with device 10
- connector terminal 114 of stimulation lead 110 may be inserted, per arrow I′, into port 104 of adapter lead 100 , for electrical coupling with device 10 , via adapter lead 100 , by the mating of each connector element 117 with a corresponding electrical contact 107 mounted within port 104
- Either one or both of leads 100 , 110 may employ any of the lead body constructions disclosed herein, in order to facilitate the corresponding insertion, examples of which are described below, in conjunction with FIGS. 2-5 .
- FIG. 2 is a cross-section perspective view of a lead body construction, according to a first group of embodiments.
- FIG. 2 illustrates lead body 101 / 111 including an outer sheath 220 , a first lumen 201 , in which conductors 215 extend, and a second lumen 202 extending alongside first lumen 201 ; each of first and second lumens 201 , 202 extend longitudinally within sheath 220 between proximal end 103 / 113 and distal end 105 / 115 of lead body 101 / 111 ( FIG. 1 ).
- second lumen 202 is defined by an elongate tube 20 extending within a portion of first lumen 201 , and a central longitudinal axis A 2 of second lumen 202 is radially offset from a central longitudinal axis A 1 of first lumen 201 . While tube 20 is illustrated having a generally circular cross-section, other cross-section shapes can be employed.
- FIG. 2 further illustrates a first filler 211 extending around conductors 215 within first lumen 201 , and a second filler 212 extending within second lumen 202 .
- second filler 212 has a stiffness greater than that of first filler 211 , and, with reference back to FIG. 1 , second filler 212 extends along a proximally located limited length L 2 , preferably no greater than approximately two inches.
- Tube 20 may extend beyond length L 2 or may have a length approximately equal to length L 2 .
- FIG. 3 is a cross-section perspective view of a lead body construction, according to a second group of embodiments.
- FIG. 3 illustrates lead body 101 / 111 including an outer sheath 320 , a first lumen 301 , in which conductors 215 extend, and a second lumen 302 extending alongside first lumen 301 ; each of first and second lumens 301 , 302 extend longitudinally within sheath 320 between proximal end 103 / 113 and distal end 105 / 115 of lead body 101 / 111 ( FIG. 1 ).
- first and second lumens 301 , 302 extend independent of one another within sheath 320 , each having a central longitudinal axis B 1 , B 2 , respectively, being radially offset from the other and being radially offset from a central longitudinal axis B 3 of sheath.
- FIG. 3 further illustrates first filler 211 extending around conductors 215 within first lumen 301 , and second filler 212 extending within second lumen 302 . Similar to the embodiments illustrated by FIG. 2 , second filler 212 extends along a proximally located limited length L 2 ( FIG. 1 ).
- first filler 211 may fill up to an entire length of first lumen 201 / 301 between proximal end 103 / 113 and distal end 105 / 115 of lead body 101 / 111 in order to provide support and/or electrical isolation for conductors 215 , without significantly stressing conductors 215 and without significantly increasing a stiffness of lead body 101 / 111 ; while second filler 212 , having a greater stiffness than first filler 211 , being relatively rigid, provides added rigidity to lead body 101 / 111 , along length L 2 , for example, between approximately three quarters of an inch and approximately two inches, in order to facilitate insertion of connector terminal 102 / 114 .
- second filler 212 being contained in second lumen 202 / 302 , is separated from conductors 215 and can thereby stiffen the proximal portion of lead body 101 / 111 without coming into contact with conductors 215 , although this is not essential.
- conductors 215 are cabled bundles of fine wires which may be drawn filled tubes (DFT), for example, silver-cored MP35N alloy, known to those skilled in the art.
- Conductors 215 may be covered, for example, via coating or extrusion, with an insulative jacket, for example fluoropolymer or polyimide, and, if the insulative jacket of each conductor 215 is sufficient to provide all the necessary electrical isolation for conductors 215 , first filler 211 need not provide for electrical isolation therebetween; thus, first filler 211 may only extend along a limited length of lead body 101 / 111 , like second filler 212 , for example, along a length only slightly longer than L 2 to provide some strain relief at a distal termination of second filler 212 .
- DFT drawn filled tubes
- MP35N alloy silver-cored MP35N alloy
- Sheaths 220 and 320 may be formed, for example, via extrusion, from medical grade silicone rubber or polyurethane; tube 20 ( FIG. 2 ) may likewise be formed from either medical grade silicone rubber or polyurethane, or from a fluoropolymer such as polytetrafluoroethylene (PTFE) or Ethylene TetrafluoroEthylene (ETFE).
- PTFE polytetrafluoroethylene
- ETFE Ethylene TetrafluoroEthylene
- first and second fillers 211 , 212 comprise adhesive materials; preferably first filler 211 comprises a silicone medical adhesive and second filler 212 comprises a thermosetting epoxy adhesive.
- Second filler 212 may, alternatively, be a pre-formed component, for example, a metal or relatively rigid plastic insert, or, according to some embodiments, a combination of an adhesive material and an insert, embodiments of which will be described below.
- Each of fillers 211 , 212 may be dispensed, via syringe injection, into corresponding first and second lumens 201 / 301 , 202 / 302 , either before or after connector terminal 102 / 114 is assembled; likewise a pre-formed component, comprising all or part of second filler 212 , may be inserted into second lumen 202 / 302 either before or after connector terminal 102 / 114 is assembled.
- FIG. 4A is an exploded plan view of a proximal portion of a lead assembly, either for adapter lead 100 or for stimulation lead 110
- FIG. 4B is an end view of a corresponding connector terminal subassembly 420 , at a distal end 405 thereof, for either of connector terminals 102 and 114 , according to some embodiments.
- FIGS. 4A-B illustrate connector terminal subassembly 420 including an insulative structure 40 on which conductive rings 42 are mounted, for example, via insert molding; structure 40 may be formed from a relatively rigid biocompatible plastic, for example, a 75 D durometer polyurethane.
- conductors 215 are passed into a longitudinally extending lumen 47 of structure 40 , per arrow J, such that a conductive component 41 , which is coupled, for example, via crimping, to each conductor 215 , may be inserted into a slot 402 of the corresponding conductive ring 42 for coupling thereto, for example, via laser welding, in order to form connector elements 106 / 117 ( FIG. 1 ).
- FIG. 4A-B further illustrate distal end 405 of connector terminal subassembly 420 including a mating feature or sleeve 45 for attaching proximal end 103 / 113 of lead body 101 / 111 to subassembly 420 , for example, via adhesive or thermal bonding of sheath 220 / 320 within sleeve 45 , according to an exemplary embodiment.
- first filler 211 may be dispensed directly into first lumen 201 / 301 , and second filler 212 directly into second lumen 202 / 302 , each at proximal end 103 / 113 , per arrows D 1 and D 2 , respectively, prior to attaching proximal end 103 / 113 to subassembly 420 .
- an optional port 43 is shown extending through a sidewall of sheath 220 / 320 for access to first lumen 201 / 301 , so that first filler 211 , for example, comprising silicone medical adhesive, may alternately be dispensed therethrough; another optional port may be provided for dispensing of second filler 212 into second lumen 202 / 302 .
- first filler 211 for example, comprising silicone medical adhesive
- lumen 47 of connector subassembly 420 may include an opening at a proximal end 403 thereof, so that one or both of fillers 211 , 212 may be assembled, via lumen 47 , per arrow K, into lead body 101 / 111 after connector terminal 102 / 114 is assembled, although this is not essential.
- first and second fillers 211 , 212 further extend into connector terminal 102 / 114 , for example, as illustrated by dashed lines and cross-hatching in the end view of FIG. 4B .
- tube 20 which forms second lumen 202 , extends proximally from sheath 220 , of lead body 101 / 111 , and into connector terminal 102 / 114 , in order to contain second filler 212 therein, and to separate second filler 212 from first filler 211 .
- First filler 211 is preferably dispensed, via syringe injection, into first lumen 201 / 301 of lead body 101 / 111 and into lumen 47 of connector terminal subassembly 420 , after conductors 215 are coupled, via conductive components 41 , to rings 42 .
- Second filler 212 either embodied as an epoxy adhesive, or as a pre-formed component, or as a combination thereof, may be assembled into lumen 47 either before or after the coupling of conductors 215 , but, preferably, before the dispensing of first filler 211 into lumen 47 .
- second filler 212 includes epoxy adhesive filling a pre-formed tubular insert, for example, tube 20 of FIG. 2 , or tube 60 , which is shown in FIG. 5 .
- FIG. 5 is a perspective view of second filler 212 embodied as a pre-formed filler component 62 , according to an exemplary embodiment.
- FIG. 5 illustrates filler component 62 including tube 60 , epoxy adhesive 610 , which fills at least a portion of a length L 6 of tube 60 , and an optional pre-formed reinforcing member 65 , which is shown with dashed lines extending within tube 60 .
- FIG. 5 is a perspective view of second filler 212 embodied as a pre-formed filler component 62 , according to an exemplary embodiment.
- FIG. 5 illustrates filler component 62 including tube 60 , epoxy adhesive 610 , which fills at least a portion of a length L 6 of tube 60 , and an optional pre-formed reinforcing member 65 , which is shown with das
- tube 60 including a coil member 621 surrounded by a polymer jacket 622 , for example, a fluoropolymer tube that has been attached thereto via a heat shrink method known to those skilled in the art.
- length L 6 of tube 60 may be limited so as not to extend from connector terminal 102 / 114 , within lead body 101 / 111 , distally past a distal termination of limited length L 2 , or length L 6 may be longer to extend distally within lead body 101 / 111 beyond the distal termination of length L 2 .
- filler component 62 is assembled by first attaching jacket 622 about coil member 621 , to form tube 60 , and then by dispensing the epoxy adhesive 610 , for example, by injecting, from a syringe, into tube 60 .
- the epoxy adhesive 610 may be cured, within tube 60 , at a temperature of approximately 150° F., for between approximately 12 and 24 hours, prior to inserting filler component 62 , as second filler 212 , into lumen 202 / 302 ( FIGS. 2-3 ), and, for some embodiments, also into lumen 47 of connector terminal subassembly 420 , for example, at proximal end 403 of subassembly 420 , via arrow K ( FIG.
- member 65 may be inserted into tube 60 either before or after adhesive 610 is injected; according to a preferred method step, member 65 , for example, a metal wire insert having a length of approximately 1.5 inches and a diameter on the order of 0.010 inch, is inserted with a rotation into tube 60 immediately after the epoxy adhesive 610 is injected therein; the rotation may assure uniform coverage of member 65 with adhesive 610 .
- second filler 212 embodied as an epoxy adhesive, is dispensed, into second lumen 202 / 302 of sheath 220 / 320 , from a syringe, via a needle coupled thereto, which needle has been passed, per arrow K, into lumen 47 , from proximal end 403 , for access into second lumen 202 / 302 .
- first filler 211 embodied as a silicone adhesive, may be dispensed from a syringe into first lumen 201 / 301 , and optionally within lumen 47 ; alternatively, port 43 may provide access for the syringe needle to dispense first filler 211 .
- second filler 212 comprises a pre-formed component
- the preformed component may be inserted into second lumen 202 / 302 , via lumen 47 , from proximal end 403 , and may further extend into lumen 47 , as previously described.
- FIG. 6 is a cross-section perspective view of a lead body construction, according to a third group of embodiments.
- FIG. 6 illustrates lead body 101 / 111 including an outer sheath 520 , a first lumen 501 , in which a multi-conductor coil 53 extends, and a second lumen 502 extending alongside and within first lumen 501 ; each of first and second lumens 501 , 502 extend longitudinally within sheath 520 between proximal end 103 / 113 and distal end 105 / 115 of lead body 101 / 111 ( FIG. 1 ).
- multi-conductor coil 53 includes a plurality of coiled conductor filars, each of which are individually insulated, for example, by a coating of polyimide, and that each coiled conductor filar electrically couples an electrode 118 to a corresponding connector element 107 , for stimulation lead 110 , or an electrical contact 107 to a corresponding connector element 106 , for adapter lead 100 .
- second lumen 502 is formed by an elongate tube 50 extending approximately coaxially within first lumen 501 , such that a central longitudinal axis C 2 of second lumen 502 is approximately aligned with a central longitudinal axis C 1 of first lumen 501 .
- FIG. 6 further illustrates first filler 211 extending around multi-conductor coil 53 within first lumen 501 , and second filler 212 extending within second lumen 502 .
- second filler 212 preferably extends along proximally located limited length L 2 .
- Tube 50 may extend beyond length L 2 or may have a length approximately equal to length L 2 .
- first filler 211 may provide support and/or additional electrical isolation for coil 53 , either along a length approximately equal to limited length L 2 , or along a greater length, between proximal end 103 / 113 and distal end 105 / 115 of lead body 101 / 111 , up to an entire length thereof, without significantly increasing a stiffness thereof, while second filler 212 provides added stiffness to lead body 101 / 111 along limited length L 2 to facilitate insertion of connector terminal 102 / 114 .
- first filler 211 and/or second filler 212 may further extend into connector terminal 102 / 114 , as previously described in conjunction with FIGS. 4A-B .
Abstract
Description
- The present disclosure pertains to implantable medical systems and more particularly to lead body constructions for implantable medical electrical leads.
- The medical device industry produces a variety of implantable medical device systems that provide electrical stimulation therapy to patients suffering from cardiac and/or neurological disorders. Examples of these implantable systems include those providing cardiac pacing and/or defibrillation, and those providing neuromodulation. Electrical stimulation is typically delivered through one or more electrodes of a stimulation lead, implanted in intimate contact with tissue at specific sites, for example, in contact with myocardial, spinal cord, peripheral nerve, or brain tissue; the one or more electrodes are coupled to a stimulation source, or device, which is implanted in a subcutaneous pocket, by corresponding isolated conductors that extend, within an elongate insulative lead body, from the device, in the pocket, to the electrodes, at the stimulation site. The conductors are typically coupled to the device via a connector terminal, which is designed for reversible connection within a connector port of the device and that extends proximally from a proximal end of the elongate lead body.
- Because the subcutaneous pocket for the device implant is typically somewhat remote from the stimulation site, elongate insulative lead bodies are designed to have a sufficient length, flexibility and durability to be routed through and/or around anatomical structures, between the pocket and the stimulation site, and to protect and isolate the conductors and electrodes of the lead from one another and from the implant environment. In some cases another lead, including an additional set of conductors, an associated lead body, a connector port, and a connector terminal, is included in the system, either to extend a length of the stimulation lead, or to convert the connector of the stimulation lead to another type of connector, which is compatible with a particular type of device connector port.
- Lead connector terminals are typically coupled to device connector ports, as well as to connector ports of other leads, by grasping the associated lead body in proximity to the connector terminal and inserting the connector terminal into the port.
- The following drawings are illustrative of particular embodiments and therefore do not limit the scope of the invention. The drawings are not to scale (unless so stated) and are intended for use in conjunction with the explanations in the following detailed description. Embodiments of the present disclosure will hereinafter be described in conjunction with the appended drawings, wherein like numerals denote like elements.
-
FIG. 1 is a plan view of an exemplary system which may employ embodiments of the present disclosure. -
FIG. 2 is a cross-section perspective view of a lead body construction, according to a first group of embodiments. -
FIG. 3 is a cross-section perspective view of a lead body construction, according to a second group of embodiments. -
FIG. 4A is an exploded plan view of a portion of a lead assembly, according to some embodiments. -
FIG. 4B is an end view of a connector terminal subassembly of the lead assembly shown inFIG. 4A , according to some embodiments. -
FIG. 5 is a perspective view of a filler component, according to some embodiments. -
FIG. 6 is a cross-section perspective view of a lead body construction, according to a third group of embodiments. - Various lead body constructions, which have enhanced stiffness to increase an ease of insertion for connector terminals have been described in the art, however there is still a need for new lead body constructions that provide the requisite stiffness without complicating methods for connector assembly and without compromising the flexibility and durability of the corresponding lead.
- The following detailed description is exemplary in nature and is not intended to limit the scope, applicability, or configuration of the invention in any way. Rather, the following description provides practical illustrations for implementing exemplary embodiments. Examples of constructions, materials, dimensions, and manufacturing processes are provided for selected elements, and all other elements employ that which is known to those of skill in the field of the invention. Utilizing the teaching provided herein, those skilled in the art will recognize that many of the examples have suitable alternatives that can be utilized.
-
FIG. 1 is a plan view of an exemplary implantable medical electrical system which may employ embodiments of the present disclosure.FIG. 1 illustrates the system including an implantablemedical device 10, and a lead system formed by anadapter lead 100 and astimulation lead 110.Adapter lead 100 may be employed to extend a length oflead 110 and/or to convert aconnector terminal 114 oflead 110 to adifferent connector terminal 102 for compatibility with a connector port (not shown) of aconnector module 12 ofdevice 10. Those skilled in the art will appreciate thatconnector module 12 contains electrical contacts, within the port thereof, which are adapted to mate withindividual connector elements 106 ofconnector terminal 102, and/or withindividual connector elements 117 of connector terminal 114 (ifterminal 114 is compatible with the device connector port), and that hermitically sealed feedthrough assemblies couple each of the electrical contacts ofconnector module 12 with a power supply and electronic circuitry contained within ahousing 15 ofdevice 10. Those skilled in the art will further appreciate thatconnector elements 106, ofconnector terminal 102, are isolated from one another by insulative spacers extending therebetween; likewise,connector elements 117, ofconnector terminal 114, are isolated from one another by corresponding insulative spacers. It should be noted that, although the illustrated in-line configuration ofconnector terminals -
FIG. 1 further illustratesstimulation lead 110 andadapter lead 100 each including an elongateinsulative lead body 111 and 101, respectively; stimulation lead body 111 includes aproximal end 113, from whichconnector terminal 114 extends, and adistal end 115, from which anelectrode array 116 extends; andadapter lead body 101 includes aproximal end 103, from whichconnector terminal 102 extends, and adistal end 105, from which aconnector port 104 extends.Electrode array 116 is shown including a plurality ofelectrodes 118, which are isolated from one another, being mounted on aninsulative member 119; eachelectrode 118 is coupled to acorresponding connector element 117, via a corresponding isolated conductor 215 (FIGS. 2-3 ) that extends within lead body 111, betweenproximal end 113 anddistal end 115.Connector port 104 is shown extending within aninsulative housing 108 and including a plurality ofelectrical contacts 107, which are isolated from one another, for example, by internal sealing rings, which are known to those skilled in the art; eachcontact 107 is coupled to acorresponding connector element 106, via a correspondingisolated conductor 215 that extends withinlead body 101, betweenproximal end 103 anddistal end 105. Any suitable components and construction methods, which are known to those skilled in the art, may be employed to manufactureelectrode array 116,connector terminals connector port 104 and to couple these elements to the ends of the corresponding lead body; some exemplary construction methods will be described, below, in conjunction withFIGS. 4A-B , forconnector terminals - With further reference to
FIG. 1 ,connector terminal 102 ofadapter lead 100 may be inserted, per arrow I, into the port ofmodule 12 for electrical coupling withdevice 10, andconnector terminal 114 ofstimulation lead 110 may be inserted, per arrow I′, intoport 104 ofadapter lead 100, for electrical coupling withdevice 10, viaadapter lead 100, by the mating of eachconnector element 117 with a correspondingelectrical contact 107 mounted withinport 104. Either one or both ofleads FIGS. 2-5 . -
FIG. 2 is a cross-section perspective view of a lead body construction, according to a first group of embodiments.FIG. 2 illustrateslead body 101/111 including anouter sheath 220, a first lumen 201, in whichconductors 215 extend, and asecond lumen 202 extending alongside first lumen 201; each of first andsecond lumens 201, 202 extend longitudinally withinsheath 220 betweenproximal end 103/113 anddistal end 105/115 oflead body 101/111 (FIG. 1 ). According to the illustrated embodiment,second lumen 202 is defined by anelongate tube 20 extending within a portion of first lumen 201, and a central longitudinal axis A2 ofsecond lumen 202 is radially offset from a central longitudinal axis A1 of first lumen 201. Whiletube 20 is illustrated having a generally circular cross-section, other cross-section shapes can be employed. -
FIG. 2 further illustrates afirst filler 211 extending aroundconductors 215 within first lumen 201, and asecond filler 212 extending withinsecond lumen 202. According to exemplary embodiments,second filler 212 has a stiffness greater than that offirst filler 211, and, with reference back toFIG. 1 ,second filler 212 extends along a proximally located limited length L2, preferably no greater than approximately two inches.Tube 20 may extend beyond length L2 or may have a length approximately equal to length L2. -
FIG. 3 is a cross-section perspective view of a lead body construction, according to a second group of embodiments.FIG. 3 illustrateslead body 101/111 including anouter sheath 320, afirst lumen 301, in whichconductors 215 extend, and asecond lumen 302 extending alongsidefirst lumen 301; each of first andsecond lumens sheath 320 betweenproximal end 103/113 anddistal end 105/115 oflead body 101/111 (FIG. 1 ). According to the illustrated embodiment, first andsecond lumens sheath 320, each having a central longitudinal axis B1, B2, respectively, being radially offset from the other and being radially offset from a central longitudinal axis B3 of sheath.FIG. 3 further illustratesfirst filler 211 extending aroundconductors 215 withinfirst lumen 301, andsecond filler 212 extending withinsecond lumen 302. Similar to the embodiments illustrated byFIG. 2 ,second filler 212 extends along a proximally located limited length L2 (FIG. 1 ). - With reference to
FIGS. 2 and 3 ,first filler 211, being relatively flexible, to bend without kinking or cracking, may fill up to an entire length of first lumen 201/301 betweenproximal end 103/113 anddistal end 105/115 oflead body 101/111 in order to provide support and/or electrical isolation forconductors 215, without significantly stressingconductors 215 and without significantly increasing a stiffness oflead body 101/111; whilesecond filler 212, having a greater stiffness thanfirst filler 211, being relatively rigid, provides added rigidity tolead body 101/111, along length L2, for example, between approximately three quarters of an inch and approximately two inches, in order to facilitate insertion ofconnector terminal 102/114. It should be appreciated thatsecond filler 212, being contained insecond lumen 202/302, is separated fromconductors 215 and can thereby stiffen the proximal portion oflead body 101/111 without coming into contact withconductors 215, although this is not essential. - According to some embodiments,
conductors 215 are cabled bundles of fine wires which may be drawn filled tubes (DFT), for example, silver-cored MP35N alloy, known to those skilled in the art.Conductors 215 may be covered, for example, via coating or extrusion, with an insulative jacket, for example fluoropolymer or polyimide, and, if the insulative jacket of eachconductor 215 is sufficient to provide all the necessary electrical isolation forconductors 215,first filler 211 need not provide for electrical isolation therebetween; thus,first filler 211 may only extend along a limited length oflead body 101/111, likesecond filler 212, for example, along a length only slightly longer than L2 to provide some strain relief at a distal termination ofsecond filler 212.Sheaths FIG. 2 ) may likewise be formed from either medical grade silicone rubber or polyurethane, or from a fluoropolymer such as polytetrafluoroethylene (PTFE) or Ethylene TetrafluoroEthylene (ETFE). - According to some embodiments, first and
second fillers first filler 211 comprises a silicone medical adhesive andsecond filler 212 comprises a thermosetting epoxy adhesive.Second filler 212 may, alternatively, be a pre-formed component, for example, a metal or relatively rigid plastic insert, or, according to some embodiments, a combination of an adhesive material and an insert, embodiments of which will be described below. Each offillers connector terminal 102/114 is assembled; likewise a pre-formed component, comprising all or part ofsecond filler 212, may be inserted intosecond lumen 202/302 either before or afterconnector terminal 102/114 is assembled. -
FIG. 4A is an exploded plan view of a proximal portion of a lead assembly, either foradapter lead 100 or forstimulation lead 110, andFIG. 4B is an end view of a correspondingconnector terminal subassembly 420, at adistal end 405 thereof, for either ofconnector terminals FIGS. 4A-B illustrateconnector terminal subassembly 420 including aninsulative structure 40 on which conductive rings 42 are mounted, for example, via insert molding;structure 40 may be formed from a relatively rigid biocompatible plastic, for example, a 75 D durometer polyurethane. According to the illustrated embodiment,conductors 215 are passed into alongitudinally extending lumen 47 ofstructure 40, per arrow J, such that aconductive component 41, which is coupled, for example, via crimping, to eachconductor 215, may be inserted into aslot 402 of the correspondingconductive ring 42 for coupling thereto, for example, via laser welding, in order to formconnector elements 106/117 (FIG. 1 ).FIGS. 4A-B further illustratedistal end 405 ofconnector terminal subassembly 420 including a mating feature orsleeve 45 for attachingproximal end 103/113 oflead body 101/111 tosubassembly 420, for example, via adhesive or thermal bonding ofsheath 220/320 withinsleeve 45, according to an exemplary embodiment. - With reference to
FIG. 4A , in conjunction withFIGS. 2-3 , it may be appreciated thatfirst filler 211 may be dispensed directly into first lumen 201/301, andsecond filler 212 directly intosecond lumen 202/302, each atproximal end 103/113, per arrows D1 and D2, respectively, prior to attachingproximal end 103/113 tosubassembly 420. However, anoptional port 43 is shown extending through a sidewall ofsheath 220/320 for access to first lumen 201/301, so thatfirst filler 211, for example, comprising silicone medical adhesive, may alternately be dispensed therethrough; another optional port may be provided for dispensing ofsecond filler 212 intosecond lumen 202/302. With further reference toFIGS. 4A-B ,lumen 47 ofconnector subassembly 420 may include an opening at aproximal end 403 thereof, so that one or both offillers lumen 47, per arrow K, intolead body 101/111 afterconnector terminal 102/114 is assembled, although this is not essential. - According to some preferred embodiments, either one or both of first and
second fillers connector terminal 102/114, for example, as illustrated by dashed lines and cross-hatching in the end view ofFIG. 4B . With reference back toFIG. 2 , according to some embodiments,tube 20, which formssecond lumen 202, extends proximally fromsheath 220, oflead body 101/111, and intoconnector terminal 102/114, in order to containsecond filler 212 therein, and to separatesecond filler 212 fromfirst filler 211.First filler 211, particularly when embodied as a silicone medical adhesive, is preferably dispensed, via syringe injection, into first lumen 201/301 oflead body 101/111 and intolumen 47 ofconnector terminal subassembly 420, afterconductors 215 are coupled, viaconductive components 41, to rings 42.Second filler 212, either embodied as an epoxy adhesive, or as a pre-formed component, or as a combination thereof, may be assembled intolumen 47 either before or after the coupling ofconductors 215, but, preferably, before the dispensing offirst filler 211 intolumen 47. - According to some embodiments,
second filler 212 includes epoxy adhesive filling a pre-formed tubular insert, for example,tube 20 ofFIG. 2 , ortube 60, which is shown inFIG. 5 .FIG. 5 is a perspective view ofsecond filler 212 embodied as a pre-formed filler component 62, according to an exemplary embodiment.FIG. 5 illustrates filler component 62 includingtube 60,epoxy adhesive 610, which fills at least a portion of a length L6 oftube 60, and an optional pre-formed reinforcingmember 65, which is shown with dashed lines extending withintube 60.FIG. 5 further illustratestube 60 including acoil member 621 surrounded by apolymer jacket 622, for example, a fluoropolymer tube that has been attached thereto via a heat shrink method known to those skilled in the art. With reference back toFIG. 1 , length L6 oftube 60 may be limited so as not to extend fromconnector terminal 102/114, withinlead body 101/111, distally past a distal termination of limited length L2, or length L6 may be longer to extend distally withinlead body 101/111 beyond the distal termination of length L2. - According to some preferred methods, filler component 62 is assembled by first attaching
jacket 622 aboutcoil member 621, to formtube 60, and then by dispensing theepoxy adhesive 610, for example, by injecting, from a syringe, intotube 60. Theepoxy adhesive 610 may be cured, withintube 60, at a temperature of approximately 150° F., for between approximately 12 and 24 hours, prior to inserting filler component 62, assecond filler 212, intolumen 202/302 (FIGS. 2-3 ), and, for some embodiments, also intolumen 47 ofconnector terminal subassembly 420, for example, atproximal end 403 ofsubassembly 420, via arrow K (FIG. 4A ), afterconnector terminal 102/114 is assembled. For those embodiments including optional reinforcingmember 65,member 65 may be inserted intotube 60 either before or after adhesive 610 is injected; according to a preferred method step,member 65, for example, a metal wire insert having a length of approximately 1.5 inches and a diameter on the order of 0.010 inch, is inserted with a rotation intotube 60 immediately after theepoxy adhesive 610 is injected therein; the rotation may assure uniform coverage ofmember 65 withadhesive 610. - According to some alternate assembly methods, after
connector terminal 102/114 is assembled to leadbody 101/111,second filler 212, embodied as an epoxy adhesive, is dispensed, intosecond lumen 202/302 ofsheath 220/320, from a syringe, via a needle coupled thereto, which needle has been passed, per arrow K, intolumen 47, fromproximal end 403, for access intosecond lumen 202/302. After dispensing adhesive intosecond lumen 202/302, and as the syringe needle is retracted proximally withinlumen 47, syringe may continue to dispensesecond filler 212 withinlumen 47 ofconnector subassembly 420. In a like manner, following assembly ofconnector terminal 102/114,first filler 211, embodied as a silicone adhesive, may be dispensed from a syringe into first lumen 201/301, and optionally withinlumen 47; alternatively,port 43 may provide access for the syringe needle to dispensefirst filler 211. According to those embodiments in whichsecond filler 212 comprises a pre-formed component, either alone or in combination with the adhesive, the preformed component may be inserted intosecond lumen 202/302, vialumen 47, fromproximal end 403, and may further extend intolumen 47, as previously described. -
FIG. 6 is a cross-section perspective view of a lead body construction, according to a third group of embodiments.FIG. 6 illustrateslead body 101/111 including an outer sheath 520, afirst lumen 501, in which a multi-conductor coil 53 extends, and asecond lumen 502 extending alongside and withinfirst lumen 501; each of first andsecond lumens proximal end 103/113 anddistal end 105/115 oflead body 101/111 (FIG. 1 ). Those skilled in the art will appreciate that multi-conductor coil 53 includes a plurality of coiled conductor filars, each of which are individually insulated, for example, by a coating of polyimide, and that each coiled conductor filar electrically couples anelectrode 118 to acorresponding connector element 107, forstimulation lead 110, or anelectrical contact 107 to acorresponding connector element 106, foradapter lead 100. - According to the illustrated embodiment,
second lumen 502 is formed by an elongate tube 50 extending approximately coaxially withinfirst lumen 501, such that a central longitudinal axis C2 ofsecond lumen 502 is approximately aligned with a central longitudinal axis C1 offirst lumen 501.FIG. 6 further illustratesfirst filler 211 extending around multi-conductor coil 53 withinfirst lumen 501, andsecond filler 212 extending withinsecond lumen 502. With reference back toFIG. 1 ,second filler 212 preferably extends along proximally located limited length L2. Tube 50 may extend beyond length L2 or may have a length approximately equal to length L2. Like the embodiments described in conjunction withFIGS. 2-3 ,first filler 211 may provide support and/or additional electrical isolation for coil 53, either along a length approximately equal to limited length L2, or along a greater length, betweenproximal end 103/113 anddistal end 105/115 oflead body 101/111, up to an entire length thereof, without significantly increasing a stiffness thereof, whilesecond filler 212 provides added stiffness to leadbody 101/111 along limited length L2 to facilitate insertion ofconnector terminal 102/114. Furthermore, for those embodiments employing the lead body construction ofFIG. 6 ,first filler 211 and/orsecond filler 212 may further extend intoconnector terminal 102/114, as previously described in conjunction withFIGS. 4A-B . - In the foregoing detailed description, the invention has been described with reference to specific embodiments. However, it may be appreciated that various modifications and changes can be made without departing from the scope of the invention as set forth in the appended claims.
Claims (46)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/843,021 US7974704B2 (en) | 2007-08-22 | 2007-08-22 | Lead body constructions for implantable medical electrical leads |
PCT/US2008/071977 WO2009029389A1 (en) | 2007-08-22 | 2008-08-01 | Lead body constructions for implantable medical electrical leads |
EP08828503A EP2190523A1 (en) | 2007-08-22 | 2008-08-01 | Lead body constructions for implantable medical electrical leads |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/843,021 US7974704B2 (en) | 2007-08-22 | 2007-08-22 | Lead body constructions for implantable medical electrical leads |
Publications (2)
Publication Number | Publication Date |
---|---|
US20090054949A1 true US20090054949A1 (en) | 2009-02-26 |
US7974704B2 US7974704B2 (en) | 2011-07-05 |
Family
ID=39791429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/843,021 Expired - Fee Related US7974704B2 (en) | 2007-08-22 | 2007-08-22 | Lead body constructions for implantable medical electrical leads |
Country Status (3)
Country | Link |
---|---|
US (1) | US7974704B2 (en) |
EP (1) | EP2190523A1 (en) |
WO (1) | WO2009029389A1 (en) |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080167515A1 (en) * | 2002-11-15 | 2008-07-10 | William Suttle Peters | Heart Assist Device Utilising Aortic Deformation |
US20100256696A1 (en) * | 2009-04-07 | 2010-10-07 | Boston Scientific Neuromodulation Corporation | Anchoring Units For Implantable Electrical Stimulation Systems And Methods Of Making And Using |
WO2010117679A1 (en) * | 2009-04-07 | 2010-10-14 | Boston Scientific Neuromodulation Corporation | Systems and methods for coupling conductors to conductive contacts of electrical stimulation systems |
US20110301680A1 (en) * | 2007-09-13 | 2011-12-08 | Medtronic, Inc. | Medical electrical lead |
US20120041508A1 (en) * | 2009-04-23 | 2012-02-16 | Benny Rousso | Implantable lead connector |
WO2013176746A1 (en) * | 2012-05-22 | 2013-11-28 | Sunshine Heart Company, Pty Ltd | Methods, systems, and devices relating to a removable percutaneous interface line |
US8702583B2 (en) | 2003-11-11 | 2014-04-22 | Sunshine Heart Company Pty, Ltd. | Actuator for a heart assist device |
US9042979B2 (en) | 2010-04-02 | 2015-05-26 | Sunshine Heart Company Pty Limited | Combination heart assist systems, methods, and devices |
US9119908B2 (en) | 2003-10-31 | 2015-09-01 | Sunshine Heart Company Pty. Ltd. | Synchronization control system |
US20160001061A1 (en) * | 2012-12-21 | 2016-01-07 | Boston Scientific Neuromodulation Corporation | Leads with proximal stiffening and related methods of use and manufacture |
JP2016507350A (en) * | 2013-03-06 | 2016-03-10 | カーディアック ペースメイカーズ, インコーポレイテッド | Pacing leads with structured coating |
US9364658B2 (en) | 2014-03-03 | 2016-06-14 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads with multiple anchoring units and methods of making and using |
US9533141B2 (en) | 2014-07-07 | 2017-01-03 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with elongate anchoring elements |
US9649489B2 (en) | 2014-06-02 | 2017-05-16 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with anchoring units having struts and methods of making and using |
US9669210B2 (en) | 2014-04-22 | 2017-06-06 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with folding anchoring units and methods of making and using |
US9814875B2 (en) | 2013-03-06 | 2017-11-14 | Cardiac Pacemakers, Inc. | Medical device with a structured coating |
US20190030345A1 (en) * | 2017-07-25 | 2019-01-31 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using an enhanced connector of an electrical stimulation system |
US10406353B2 (en) | 2013-05-14 | 2019-09-10 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads with anchoring unit and electrode arrangement and methods of making and using |
US11491338B2 (en) | 2014-07-11 | 2022-11-08 | Cardiac Pacemakers, Inc. | Polymeric feed-thru for chronic implantable devices |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8380325B2 (en) * | 2009-08-05 | 2013-02-19 | Boston Scientific Neuromodulation Corporation | Systems and methods for coupling coiled conductors to conductive contacts of an electrical stimulation system |
EP2603281B1 (en) * | 2010-08-13 | 2019-02-27 | Cathrx Ltd | A method of fabricating an electrical lead |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172451A (en) * | 1978-04-06 | 1979-10-30 | Medical Evaluation Devices And Instruments Corp. | Intracardial electrode and a method of manufacture thereof |
US4379462A (en) * | 1980-10-29 | 1983-04-12 | Neuromed, Inc. | Multi-electrode catheter assembly for spinal cord stimulation |
US4944088A (en) * | 1988-05-25 | 1990-07-31 | Medtronic, Inc. | Ring electrode for multiconductor pacing leads |
US5466253A (en) * | 1993-04-27 | 1995-11-14 | Pacesetter, Inc. | Crush resistant multi-conductor lead body |
US5876430A (en) * | 1997-12-17 | 1999-03-02 | Medtronic, Inc. | Method to stiffen and provide abrasion to connector end of leads |
US5935159A (en) * | 1996-12-19 | 1999-08-10 | Medtronic, Inc. | Medical electrical lead |
US6096069A (en) * | 1995-12-28 | 2000-08-01 | Medtronic, Inc. | Medical electrical lead with conductors coiled around an inner tube |
US6434430B2 (en) * | 1999-03-18 | 2002-08-13 | Medtronic, Inc. | Co-extruded, multi-lumen medical lead |
US20020183824A1 (en) * | 2001-05-09 | 2002-12-05 | Medtronic, Inc. | Co-extruded, multi-lumen medical lead |
US20040215300A1 (en) * | 2003-04-23 | 2004-10-28 | Medtronic, Inc. | Electrical medical leads employing conductive aerogel |
US20050137665A1 (en) * | 2003-10-03 | 2005-06-23 | Medtronic Inc. | Implantabel electrical connector system |
US7130699B2 (en) * | 2003-05-13 | 2006-10-31 | Medtronic, Inc. | Medical lead adaptor assembly |
US20070225784A1 (en) * | 2006-03-23 | 2007-09-27 | Cardiac Pacemakers, Inc. | Medical lead having a variable change in stiffness |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPN487495A0 (en) | 1995-08-18 | 1995-09-14 | Cardiac Crc Nominees Pty Limited | A multipolar transmural probe |
-
2007
- 2007-08-22 US US11/843,021 patent/US7974704B2/en not_active Expired - Fee Related
-
2008
- 2008-08-01 EP EP08828503A patent/EP2190523A1/en not_active Withdrawn
- 2008-08-01 WO PCT/US2008/071977 patent/WO2009029389A1/en active Application Filing
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4172451A (en) * | 1978-04-06 | 1979-10-30 | Medical Evaluation Devices And Instruments Corp. | Intracardial electrode and a method of manufacture thereof |
US4379462A (en) * | 1980-10-29 | 1983-04-12 | Neuromed, Inc. | Multi-electrode catheter assembly for spinal cord stimulation |
US4944088A (en) * | 1988-05-25 | 1990-07-31 | Medtronic, Inc. | Ring electrode for multiconductor pacing leads |
US5466253A (en) * | 1993-04-27 | 1995-11-14 | Pacesetter, Inc. | Crush resistant multi-conductor lead body |
US6096069A (en) * | 1995-12-28 | 2000-08-01 | Medtronic, Inc. | Medical electrical lead with conductors coiled around an inner tube |
US5935159A (en) * | 1996-12-19 | 1999-08-10 | Medtronic, Inc. | Medical electrical lead |
US5876430A (en) * | 1997-12-17 | 1999-03-02 | Medtronic, Inc. | Method to stiffen and provide abrasion to connector end of leads |
US6434430B2 (en) * | 1999-03-18 | 2002-08-13 | Medtronic, Inc. | Co-extruded, multi-lumen medical lead |
US20020183824A1 (en) * | 2001-05-09 | 2002-12-05 | Medtronic, Inc. | Co-extruded, multi-lumen medical lead |
US20040215300A1 (en) * | 2003-04-23 | 2004-10-28 | Medtronic, Inc. | Electrical medical leads employing conductive aerogel |
US7130699B2 (en) * | 2003-05-13 | 2006-10-31 | Medtronic, Inc. | Medical lead adaptor assembly |
US20050137665A1 (en) * | 2003-10-03 | 2005-06-23 | Medtronic Inc. | Implantabel electrical connector system |
US20070225784A1 (en) * | 2006-03-23 | 2007-09-27 | Cardiac Pacemakers, Inc. | Medical lead having a variable change in stiffness |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080167515A1 (en) * | 2002-11-15 | 2008-07-10 | William Suttle Peters | Heart Assist Device Utilising Aortic Deformation |
US9555176B2 (en) | 2002-11-15 | 2017-01-31 | Sunshine Heart Company Pty, Ltd. | Implantable device utilizing arterial deformation |
US8777833B2 (en) | 2002-11-15 | 2014-07-15 | Sunshine Heart Company Pty. Ltd. | Heart assist device utilising aortic deformation |
US9561375B2 (en) | 2003-10-31 | 2017-02-07 | Sunshine Heart Company Pty, Ltd. | Synchronization control system |
US9119908B2 (en) | 2003-10-31 | 2015-09-01 | Sunshine Heart Company Pty. Ltd. | Synchronization control system |
US8702583B2 (en) | 2003-11-11 | 2014-04-22 | Sunshine Heart Company Pty, Ltd. | Actuator for a heart assist device |
US20110301680A1 (en) * | 2007-09-13 | 2011-12-08 | Medtronic, Inc. | Medical electrical lead |
US10086189B2 (en) * | 2007-09-13 | 2018-10-02 | Medtronic, Inc. | Medical electrical lead |
US20100256696A1 (en) * | 2009-04-07 | 2010-10-07 | Boston Scientific Neuromodulation Corporation | Anchoring Units For Implantable Electrical Stimulation Systems And Methods Of Making And Using |
WO2010117679A1 (en) * | 2009-04-07 | 2010-10-14 | Boston Scientific Neuromodulation Corporation | Systems and methods for coupling conductors to conductive contacts of electrical stimulation systems |
US9610435B2 (en) * | 2009-04-07 | 2017-04-04 | Boston Scientific Neuromodulation Corporation | Anchoring units for implantable electrical stimulation systems and methods of making and using |
US20150250998A1 (en) * | 2009-04-07 | 2015-09-10 | Boston Scientific Neuromodulation Corporation | Anchoring units for implantable electrical stimulation systems and methods of making and using |
US20170151428A1 (en) * | 2009-04-07 | 2017-06-01 | Boston Scientific Neuromodulation Corporation | Anchoring units for implantable electrical stimulation systems and methods of making and using |
US9956390B2 (en) | 2009-04-23 | 2018-05-01 | Impulse Dynamics Nv | Implantable lead connector |
US9320886B2 (en) | 2009-04-23 | 2016-04-26 | Impulse Dynamics Nv | Implantable lead connector |
US8706230B2 (en) * | 2009-04-23 | 2014-04-22 | Impulse Dynamics Nv | Implantable lead connector |
US20120041508A1 (en) * | 2009-04-23 | 2012-02-16 | Benny Rousso | Implantable lead connector |
US9042979B2 (en) | 2010-04-02 | 2015-05-26 | Sunshine Heart Company Pty Limited | Combination heart assist systems, methods, and devices |
WO2013176746A1 (en) * | 2012-05-22 | 2013-11-28 | Sunshine Heart Company, Pty Ltd | Methods, systems, and devices relating to a removable percutaneous interface line |
US20160001061A1 (en) * | 2012-12-21 | 2016-01-07 | Boston Scientific Neuromodulation Corporation | Leads with proximal stiffening and related methods of use and manufacture |
US9744345B2 (en) * | 2012-12-21 | 2017-08-29 | Boston Scientific Neuromodulation Corporation | Leads with proximal stiffening and related methods of use and manufacture |
US9814875B2 (en) | 2013-03-06 | 2017-11-14 | Cardiac Pacemakers, Inc. | Medical device with a structured coating |
US9833609B2 (en) | 2013-03-06 | 2017-12-05 | Cardiac Pacemakers, Inc. | Pacing leads with a structured coating |
JP2016507350A (en) * | 2013-03-06 | 2016-03-10 | カーディアック ペースメイカーズ, インコーポレイテッド | Pacing leads with structured coating |
US10406353B2 (en) | 2013-05-14 | 2019-09-10 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads with anchoring unit and electrode arrangement and methods of making and using |
US9364658B2 (en) | 2014-03-03 | 2016-06-14 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads with multiple anchoring units and methods of making and using |
US9669210B2 (en) | 2014-04-22 | 2017-06-06 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with folding anchoring units and methods of making and using |
US9649489B2 (en) | 2014-06-02 | 2017-05-16 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with anchoring units having struts and methods of making and using |
US9533141B2 (en) | 2014-07-07 | 2017-01-03 | Boston Scientific Neuromodulation Corporation | Electrical stimulation leads and systems with elongate anchoring elements |
US11491338B2 (en) | 2014-07-11 | 2022-11-08 | Cardiac Pacemakers, Inc. | Polymeric feed-thru for chronic implantable devices |
US20190030345A1 (en) * | 2017-07-25 | 2019-01-31 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using an enhanced connector of an electrical stimulation system |
US10918873B2 (en) * | 2017-07-25 | 2021-02-16 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using an enhanced connector of an electrical stimulation system |
Also Published As
Publication number | Publication date |
---|---|
WO2009029389A1 (en) | 2009-03-05 |
US7974704B2 (en) | 2011-07-05 |
EP2190523A1 (en) | 2010-06-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7974704B2 (en) | Lead body constructions for implantable medical electrical leads | |
US8525027B2 (en) | Modular lead interconnector | |
US8019439B2 (en) | Lead assembly and method of making same | |
US8103357B2 (en) | Implantable lead including sensor | |
US7437197B2 (en) | Medical lead and manufacturing method therefor | |
EP1680180B1 (en) | Implantable medical lead and method of manufacture | |
AU2009302595B2 (en) | Electrical stimulation leads having RF compatibility and methods of use and manufacture | |
US20070178770A1 (en) | Medical electrical lead connector assembly | |
US20070250143A1 (en) | Multi-conductor ribbon coiled medical device lead | |
US20050138792A1 (en) | Method of forming a lead | |
US8588939B2 (en) | Method of assembling an implantable medical lead having passive lock mechanical body terminations | |
WO2005072818A1 (en) | Implantable lead including sensor | |
US20050004638A1 (en) | Medical lead and manufacturing method therefor | |
US11471669B2 (en) | Electrode assemblies, methods, and components thereof for implantable medical electrical leads | |
US20050004642A1 (en) | Implantable medical lead including overlay | |
US10541500B2 (en) | Connector constructions and components thereof for implantable medical electrical systems | |
US9345897B2 (en) | Multi-layer covering for control modules of electrical implantable medical devices and methods of making and using | |
US20050131507A1 (en) | Lead having reduced lead body size | |
US20230140180A1 (en) | Lead for an active implantable medical device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: MEDTRONIC, INC., MINNESOTA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ALEXANDER, JAMES A.;CHAPEAU, LOREN S.;REEL/FRAME:019729/0059 Effective date: 20070820 |
|
FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
CC | Certificate of correction | ||
FPAY | Fee payment |
Year of fee payment: 4 |
|
MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 8TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1552); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY Year of fee payment: 8 |
|
FEPP | Fee payment procedure |
Free format text: MAINTENANCE FEE REMINDER MAILED (ORIGINAL EVENT CODE: REM.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
LAPS | Lapse for failure to pay maintenance fees |
Free format text: PATENT EXPIRED FOR FAILURE TO PAY MAINTENANCE FEES (ORIGINAL EVENT CODE: EXP.); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY |
|
STCH | Information on status: patent discontinuation |
Free format text: PATENT EXPIRED DUE TO NONPAYMENT OF MAINTENANCE FEES UNDER 37 CFR 1.362 |
|
FP | Lapsed due to failure to pay maintenance fee |
Effective date: 20230705 |