US20080300535A1 - Particle cassette, method and kit therefor - Google Patents
Particle cassette, method and kit therefor Download PDFInfo
- Publication number
- US20080300535A1 US20080300535A1 US12/071,324 US7132408A US2008300535A1 US 20080300535 A1 US20080300535 A1 US 20080300535A1 US 7132408 A US7132408 A US 7132408A US 2008300535 A1 US2008300535 A1 US 2008300535A1
- Authority
- US
- United States
- Prior art keywords
- cassette
- parts
- kit according
- particles
- particle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
- A61M5/3015—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules for injecting a dose of particles in form of powdered drug, e.g. mounted on a rupturable membrane and accelerated by a gaseous shock wave or supersonic gas flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2459—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened upon internal pressure increase, e.g. pierced or burst
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49863—Assembling or joining with prestressing of part
- Y10T29/4987—Elastic joining of parts
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49863—Assembling or joining with prestressing of part
- Y10T29/49876—Assembling or joining with prestressing of part by snap fit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49885—Assembling or joining with coating before or during assembling
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49893—Peripheral joining of opposed mirror image parts to form a hollow body
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49904—Assembling a subassembly, then assembling with a second subassembly
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
- Y10T29/49947—Assembling or joining by applying separate fastener
Definitions
- the present invention relates generally to the retention of particles prior to the needleless injection of those particles in a gas stream. More specifically, the present invention relates to particle cassettes having a pair of membranes which retain the particles in a chamber therebetween.
- Needleless syringe devices are known from WO 94/24263.
- a needleless syringe is disclosed which entrains particles in a gas stream accelerated through a nozzle so that the particles may be injected into a target, such as human skin or other cells.
- a target such as human skin or other cells.
- WO 94/24263 discloses for this purpose a particle cassette comprising a central annular ring having rupturable diaphragms sealed to each face so as to form a self contained sealed unit containing the particles to be injected.
- the diaphragms rupture allowing the particles initially contained between the diaphragms to be entrained in the gas flow and then delivered into the target.
- FIGS. 1 a to ld of the accompanying schematic drawings show steps in the manufacture of the particle cassette disclosed WO 94/24263.
- a substantially annular ring ( 10 ) is shown in axi-symmetric cross-section in FIG. 1 a .
- the ring has an open central section defining a chamber ( 11 ).
- a rupturable diaphragm ( 12 ) is sealed to the bottom face of the annular ring ( 10 ). This results in the construction shown in FIG. 1 b .
- particles ( 13 ) are supplied to the chamber ( 11 ).
- the particles ( 13 ) so supplied are those to be injected into the target.
- the last stage in manufacture comprises sealing a second membrane ( 14 ) onto the other face of the annular ring so as to seal the particles ( 13 ) within the central chamber ( 11 ).
- the cassette can then be handled while the particles are maintained in a sterile environment.
- the needleless syringe comprises a reservoir ( 100 ) of compressed gas connected to a valve ( 110 ). Downstream of the valve is an expansion chamber ( 120 ) the particle cassette ( 30 ) and a nozzle section ( 140 ). As shown in FIG. 15 the nozzle section ( 140 ) comprises an upstream convergent portion ( 150 ) downstream of which is a throat ( 160 ) followed by a divergent portion ( 170 ).
- the valve ( 110 ) is actuated and gaseous pressure flows from the reservoir ( 100 ) into the expansion chamber ( 120 ).
- WO 94/24263 discloses that the diaphragm should preferably be heat sealed to the faces of the annular ring. Heat sealing has been found to be a particularly easy and repeatable method of sealing the diaphragms to the ring of the cassette body.
- the present invention seeks to alleviate this problem by providing a particle cassette, a kit of parts and a method for the manufacture therefor in which the possibility of the particles melting during manufacture is much reduced.
- kit of parts for use in the manufacture of a particle cassette for a needleless syringe device, said kit comprising:
- the membranes are sealed to first and second cassette parts (possibly by heat sealing) before the particles are supplied to either of the cassette parts, there is a much reduced possibility of the membrane heat sealing process influencing the particle condition or composition. Further, the invention provides a quick and easy method of manufacturing a particle cassette and has these advantages over processes which do not involve heat sealing.
- the first and second cassette parts are annular such that the second part is attachable concentrically around or inside the first cassette part. This allows the first cassette part to extend substantially along the whole width of the particle cassette making it easier to fill the first part with particles prior to attaching the second part.
- a snap fit may be provided for by arranging corresponding features on each of the first and second parts (for example a detent and a recess).
- a seating face on each of the first and second parts, such a seating face providing a minimum possible width of particle cassette when assembled.
- a tapered face on each of the first and second parts allows the parts to be brought together easily during assembly.
- a third cassette part may be used to attach the first and second parts together.
- the third cassette part is inserted in an annular apace between the first and second cassette parts, to provide a secure attachment (or “locking”).
- the third part preferably has a third membrane to ensure sterility and may be provided with one or more protrusions to ensure an interference fit with the second cassette part.
- a particle cassette for a needleless syringe comprising an assembled kit according to the first aspect and particles provided in the chamber between the first and second membranes.
- a needleless syringe including the particle cassette of the second aspect of the invention.
- a particle cassette for a needleless syringe device comprising:
- the sealing of the membranes to the cassette parts independently from the steps of supplying particles to one of the cassette parts and attaching the cassette parts together ensures that the method used for sealing the membranes to the cassette parts does not unduly influence the quality of the particles in the cassette.
- attaching step (d) does not involve the application of any heat at all and it is preferably carried out at the same temperature as supplying step (c) to ensure that the particles are not affected by the step of attaching the first and second cassette parts together.
- step (c) is carried out after sealing step (b) since the second membrane may be sealed to the second cassette part after the particles have been supplied to the first cassette part.
- FIGS. 1 a to 1 d are cross-sectional views showing stages in the manufacture of a particle cassette according to the prior art
- FIGS. 2 a and 2 b are cross-sectional views showing stages in the manufacture of a particle cassette according to a first embodiment of the invention
- FIG. 3 is a cross-sectional view showing an assembled particle cassette according to a second embodiment of the present invention.
- FIG. 4 is a cross-sectional view showing an assembled particle cassette according to a third embodiment of the present invention.
- FIG. 5 is a cross-sectional view showing an assembled particle cassette according to a fourth embodiment of the present invention.
- FIG. 6 is a cross-sectional view showing an assembled particle cassette according to a fifth embodiment of the present invention.
- FIG. 7 is a cross-sectional view of a second cassette part according to a sixth embodiment of the present invention.
- FIG. 8 is a cross-sectional view of a first cassette part according to a sixth embodiment of the present invention.
- FIG. 9 is a cross-sectional view along the line A-A shown in FIG. 8 ;
- FIG. 10 is a cross-sectional view of a third cassette part according to a sixth embodiment of the present invention.
- FIG. 11 is a cross-sectional view of an assembled particle cassette according to a sixth embodiment of the present invention.
- FIG. 12 shows two perspective views of a partially cut-away particle cassette according to the sixth embodiment of the present invention.
- FIG. 13 is a set of three orthographic views of an assembled particle cassette according to a seventh embodiment of the present invention.
- FIG. 14 is a set of three orthographic views of an assembled particle cassette according to a eighth embodiment of the present invention.
- FIG. 15 is a longitudinal cross-sectional view through a needleless syringe which may comprise the particle cassette of any one of the embodiments of the present invention.
- FIGS. 2 a and 2 b show an axi-symmetric cross-section of the particle cassette according to the first embodiment of the present invention.
- the heat causes local expansion of the cassette material and the recesses ( 30 , 31 ) allow the cassette material to expand without affecting the designed gas flow path (eg by restricting the diameter of the flow path).
- particles ( 24 ) are dispensed to the first cassette part ( 20 ) and the first ( 20 ) and second ( 21 ) cassette parts are attached together so as to create a closed chamber for the confinement of the particles ( 24 ) between the first ( 22 ) and second ( 23 ) membranes.
- the assembled particle cassette is shown in FIG. 2 b.
- the particle cassette is located in a needleless syringe device which may have the general construction, and method of operation, described in WO 94/24263 or WO 01/05455, the contents of which are hereby incorporated by way of reference.
- the device construction is advantageously such as to prevent the first cassette part ( 20 ) coming away from the second cassette part ( 21 ).
- the second cassette part ( 21 ) may be adhered to the first cassette part ( 20 ), for example by gluing or by taping around the external circumference of the particle cassette. This provides a sealed unit of particles which can be handled outside of the needleless syringe device with reduced possibility of particles escaping from between the two cassette halves.
- FIG. 3 A second embodiment of the invention is shown in FIG. 3 .
- the particles ( 24 ) are omitted from inside the particle cassette for the sake of clarity. Further, it is to be noted that the particle cassette shown in FIG. 3 (and those shown in FIGS. 4 to 6 as well) will, prior to assembly, make up a kit of parts according to the first aspect of the present invention.
- the first cassette part ( 20 ) is constituted by a substantially annular member which extends to a height X nearly equal to the height Y of the assembled particle cassette. This greatly facilitates the filling of the first cassette part ( 21 ) with particles ( 24 ) since a larger receptacle than is provided in the first embodiment can be used to receive particles ( 24 ). A further advantage is that the whole internal volume of the cassette can be used to hold particles. In contrast, the first embodiment can only be half filled with particles since the first cassette part ( 20 ) has a height equivalent only to approximately half the final height of the cassette.
- the second embodiment shown above has advantages over the first embodiment because it does not necessarily require an extra adhesive to be used (an interference fit is instead used) and because the first cassette part defines a larger receptacle area for receiving the particles ( 24 ).
- the second embodiment has the disadvantage that it may be difficult or fiddly to assemble, even if one or both of the engaging inner face of the second cassette part and the engaging outer face of the first cassette part is provided with a lead in taper to aid assembly.
- a cassette according to the third embodiment of the invention is provided. Such a cassette is shown in FIG. 4 .
- the outer engaging face of the first cassette part ( 20 ) and the inner engaging face of the second cassette part ( 21 ) are tapered so as to allow the second cassette part ( 21 ) to be easily placed over the first cassette part ( 20 ).
- the first cassette part ( 20 ) has a larger outer diameter than the inner diameter of the second cassette part ( 21 ) at each point along the height of the cassette. This means that as the parts are brought close to the assembled position shown in FIG. 4 , some elastic strain is established in the parts to provide a snug fit. The parts are prevented from coming apart by friction along the tapered interface ( 26 ).
- the third embodiment of the invention thus has the advantage that it is easier to assemble the kit of parts than the second embodiment of the invention.
- the width of the cassette ie the vertical dimension in FIG. 4
- the width may vary over a certain range. For example, if the parts are pressed together very strongly, the width is likely to be less than if the parts are only lightly pressed together.
- the leading edge of the first cassette part ( 20 ) may damage the seal between the second membrane ( 23 ) and the second cassette part ( 21 ) if the two parts are pushed together too strongly.
- a seating face ( 27 ) is provided to each of the first ( 20 ) and second ( 21 ) cassette parts. As is shown in FIG. 5 , once the cassette parts have been pushed together a certain amount, the seating face ( 27 ) prevents further movement in the cassette height direction (i.e. the vertical direction in FIG. 5 ).
- the fourth embodiment of the invention therefore allows the width dimension of the assembled particle cassette to be reliably ensured.
- the tapered sections ( 26 ) perform the same function as in the third embodiment and the outer surfaces of the first cassette part ( 20 ) may again be made to have a slightly larger diameter than the inner surfaces of the second cassette part ( 21 ) so as to provide an interference fit.
- the steeper angle of the lower tapered section 26 provides for a better locked fit.
- the fairly uniform cross-section in the vicinity of the membranes allows for good heat dissipation during the heat sealing process, if used.
- each of the first ( 20 ) and second ( 21 ) cassette parts of corresponding features ( 28 , 29 ) which provide for a snap fit when the first and second cassette parts are brought together.
- the first cassette part ( 20 ) comprises a detent ( 28 ) located on one of external tapered surfaces ( 26 ).
- the second cassette part ( 21 ) comprises a recess ( 29 ) on its respective tapered surface ( 26 ).
- the detent ( 28 ) locates in the recess ( 29 ) to lock the two pieces together.
- both the first and second cassette parts undergo a momentary elastic strain as the detent ( 28 ) engages in the recess ( 29 ) but, once assembled, the cassette part can be arranged so that there is little residual strain present.
- the provision of corresponding features also makes it more difficult for the first and second parts to be accidentally detached, providing a stronger lock between the first and second cassette parts and thus a more secure sealed environment for the particles. This is particularly useful when the cassette is to be subject to vibrations, such as those experienced during transportation.
- the fifth embodiment shown in FIG. 6 is considered to be the best mode of carrying out the invention.
- FIGS. 7 to 12 show a sixth embodiment of the invention. Unlike the previous embodiments, the particle cassette of the sixth embodiment has three main component parts rather than two.
- FIGS. 7 and 8 show in cross-sectional view second and first cassette parts respectively.
- the second cassette part ( 30 ) of FIG. 7 is generally cylindrical in configuration having substantially vertical inside walls ( 33 ) and ( 34 ).
- the inside wall ( 33 ) has a slightly smaller diameter than inside wall ( 34 ) for reasons that will become apparent later.
- a shoulder portion ( 31 ) is provided adjacent a seating face ( 32 ).
- the shoulder portion ( 31 ) is designed to interact with the external surface of the first cassette part ( 40 ), described hereafter.
- a recess ( 35 ) is provided at the top end of the second cassette part ( 30 ) and this recess ( 35 ) aids in assembling the cassette.
- FIG. 8 shows a first cassette part ( 40 ) according to the sixth embodiment of the present invention.
- the first cassette part ( 40 ) comprises a substantially annular member defining within its confines a receptacle for receiving particles.
- the first cassette part ( 40 ) has generally cylindrical outer walls ( 42 ) and a slightly tapered seating face ( 41 ) at its bottom end.
- the seating face ( 41 ) is intended to rest against the seating face ( 32 ) of the second cassette part ( 30 ) during use.
- the shoulder ( 31 ) of the second cassette part ( 30 ) is intended to abut the outer surface ( 42 ) of the first cassette part to provide an interference fit. This configuration is shown in FIG. 11 .
- These openings are connected by transfer ducts such that gas surrounding the first cassette part ( 40 ) may enter the receptacle for receiving particles.
- the transfer ducts are substantially conical and are angled in three dimensions such that when gas flows therethrough a sonic jet is formed which tends to create a swirling gas movement inside the chamber confining the particles.
- the transfer ducts are angled such that the gas tends to impinge against the membranes located at either side of the first cassette part ( 40 ).
- FIG. 10 shows a third particle cassette part in accordance with the sixth embodiment of the present invention.
- the formations are spaced apart by vent holes ( 54 ) that are formed such that gas may pass through the vent holes ( 54 ) when the first and third cassette parts are attached together.
- the formations ( 52 ) are shaped so as to grip, by means of friction, or interference, the top part of the first cassette part ( 40 ).
- the particle cassette according to the sixth embodiment of the invention takes the form shown in FIG. 11 when assembled.
- a first membrane ( 62 ) is heat sealed or bonded to the upper edge of the first cassette part ( 40 ).
- the second membranes ( 63 ) is heat sealed or bonded to the seating face ( 32 ) of the second cassette part ( 30 ).
- the third membrane ( 61 ) is heat sealed or bonded to the upper face of the third cassette part ( 50 ).
- the first membrane and first cassette part thus define a receptacle in which the particles may be contained.
- the openings ( 43 ) are very small such that it is very difficult for the particles to pass out of the chamber once inside.
- the membrane ( 61 ) ensures that the particles inside the cassette may not come into contact with any external particles or gases and thus the membrane ( 61 ) ensures the sterility of the cassette.
- the cassette is inserted into a needleless syringe and gas pressure is supplied to the third membrane ( 61 ).
- the membrane ( 61 ) bursts quite easily and gas enters the internal space defined by the third cassette part. Gas is able to flow through the vents ( 54 ) and into the annular space ( 67 ) between the first cassette part and the second cassette part. From there, gas may pass through the transfer ducts and out through, the openings ( 43 ) into the particle containment. The jets of gas so formed cause the particles to be fluidized and mixed. Following that, the upstream membrane ( 62 ) bursts and the particles are entrained in the bulk of the gas flow followed by the bursting of the downstream membrane ( 63 ) shortly thereafter.
- the particle cassette of the sixth embodiment provides for pre-mixing and fluidizing of the particles whilst still overcoming the problem that heat sealing of membranes can damage particles when a single piece cassette is used.
- the first to sixth embodiments are usually used in a configuration such that the particle cassette is located downstream of an expansion chamber ( 120 ) in the needleless syringe.
- the syringe is therefore complex to assemble.
- the particle cassette itself has a built in expansion chamber ( 120 ) meaning that the syringe has less components overall. This results in a decrease in manufacturing time and complexity.
- the second member is locked against the first member by means of ribs ( 74 ) on the second member which locate in spaces ( 75 ) created between the first and second members during assembly.
- the ribs ( 74 ) have a tapered front edge to aid assembly and are made so as to provide a snug interference fit with the inside annular surface ( 78 ) of the first member.
- this embodiment comprises an open chamber ( 76 ) that is arranged to open outwardly of the assembled cassette.
- the chamber ( 76 ) lies above (i.e. upstream of) the membrane ( 73 ) which separates it from the particle confinement chamber ( 77 ).
- the chamber ( 76 ) performs the function of the expansion chamber ( 120 ) shown in FIG. 15 .
- FIG. 15 is schematic so that, even though FIG. 15 shows an expansion chamber ( 120 ) which diverges in the downstream direction, the expansion chamber provided by chamber ( 76 ) of the particle cassette of the seventh embodiment converges in the downstream direction and this results in a needleless syringe which works adequately.
- FIG. 14 An eighth embodiment of the invention is shown in FIG. 14 .
- the eighth embodiment has a construction very similar to that of the seventh embodiment, save for the particular manner in which the first cassette part ( 80 ) is connected to the second cassette part ( 82 ). Whilst in the seventh embodiment the two parts are pushed together to form an interference fit, the two parts are screwed together in the eighth embodiment by means of threads ( 84 and 85 ).
- a thread ( 84 ) is located on the outer surface of the second cassette part ( 82 ) and is designed to mate with a corresponding thread ( 85 ) located on the inner surface of first cassette part ( 80 ).
- the first cassette part ( 70 or 80 ) contains annular longitudinal protrusions which extend beyond the plane of the upstream membrane ( 73 or 83 ) in use. These protrusions allow the first part ( 70 or 80 ) to be connected to the respective second part ( 72 or 82 ) either by means of an interference fit as shown in FIG. 13 , or by means of a screw thread as shown in FIG. 14 .
- the screw thread is preferably relatively coarse such that the first and second cassette parts can be connected together with relatively few turns.
- less than one turn of relative movement is necessary, more preferably 180° or less of relative rotation.
- a range of movement between 45° and 120°, preferably 90° is sufficient to attach the first and second cassette parts together.
- the various means for attaching the cassette parts shown in the first to seventh embodiments may be combined with the features of the eighth embodiment, for example, seating faces, tapers and detents which provide a “snap-fit” can all be used in combination with the screw thread attachment.
- a third cassette part may be used in the seventh and eighth embodiments to lock the first and second cassette parts together.
- indents ( 88 ) are provided on the outer circumferential surface of the second cassette part ( 82 ). These indents are designed to receive a tool which assists in applying a torque to the second cassette part ( 82 ) when it is screwed to the first cassette part ( 80 ). Similar indents may also be provided on the first cassette part ( 80 ) if required.
- the screw thread design of the eighth embodiment has been found to give a more reproducible face seal between the mating surfaces of the first and second cassette parts. This helps to prevents egress of payload from the chamber ( 87 ) inside the assembled cassette, and gives a more consistent barrier to potential biological contamination. Furthermore, the integration of the expansion chamber ( 120 ) with the particle cassette makes the overall dimensions of the cassette larger than in the prior art which facilitates handling and manipulation during manufacture of the needleless syringe comprising the casssette.
- the materials used to manufacture the cassette parts and the membranes may be conventional, for example, the membranes may be Mylar as disclosed in WO 94/24263 and the first and second cassette parts are preferably manufactured from a plastics material, using injection moulding for example. Both the membranes and cassette parts may be made from polycarbonate such as Evaxone 260 (EVA) polymer. If heat sealing is used, a temperature of 110° C. and pressure of 760 kPa (110 psi) for 1.5 seconds has been found to be acceptable.
- EVA Evaxone 260
- the cassette is suitable for any type of particle that one intends to deliver, including powdered drugs (therapeutics, medicaments, vaccines, anaesthetics, analgesics, and the like), diagnostic particles (whether inert or comprising an active ingredient), and carrier particles coated with peptides, proteins or genetic material.
Abstract
A kit of parts for use in the manufacture of a self-contained particle cassette for a needleless syringe device. In an exemplary embodiment, the kit includes a first cassette part having a first rupturable membrane sealed thereto, and a second cassette part having a second rupturable membrane sealed thereto. In this exemplary embodiment, the first and second cassette parts are arranged to be attached together by a method other than heat sealing so as to form the self-contained particle cassette and so as to create a chamber for the confinement of particles between the first and second membranes.
Description
- The present invention relates generally to the retention of particles prior to the needleless injection of those particles in a gas stream. More specifically, the present invention relates to particle cassettes having a pair of membranes which retain the particles in a chamber therebetween.
- Needleless syringe devices are known from WO 94/24263. In this document, a needleless syringe is disclosed which entrains particles in a gas stream accelerated through a nozzle so that the particles may be injected into a target, such as human skin or other cells. For many applications, there is a need for the particles to be maintained in a sterile environment prior to actuation of the device. WO 94/24263 discloses for this purpose a particle cassette comprising a central annular ring having rupturable diaphragms sealed to each face so as to form a self contained sealed unit containing the particles to be injected. Upon actuation of the device, the diaphragms rupture allowing the particles initially contained between the diaphragms to be entrained in the gas flow and then delivered into the target.
-
FIGS. 1 a to ld of the accompanying schematic drawings show steps in the manufacture of the particle cassette disclosed WO 94/24263. A substantially annular ring (10) is shown in axi-symmetric cross-section inFIG. 1 a. The ring has an open central section defining a chamber ( 11). In a first step of the manufacturing process a rupturable diaphragm (12) is sealed to the bottom face of the annular ring (10). This results in the construction shown inFIG. 1 b. Then, as shown inFIG. 1 c, particles (13) are supplied to the chamber (11). The particles (13) so supplied are those to be injected into the target. The last stage in manufacture comprises sealing a second membrane (14) onto the other face of the annular ring so as to seal the particles (13) within the central chamber (11). The cassette can then be handled while the particles are maintained in a sterile environment. - An exemplary needleless syringe is shown in
FIG. 15 . As can be seen, the needleless syringe comprises a reservoir (100) of compressed gas connected to a valve (110). Downstream of the valve is an expansion chamber (120) the particle cassette (30) and a nozzle section (140). As shown inFIG. 15 the nozzle section (140) comprises an upstream convergent portion (150) downstream of which is a throat (160) followed by a divergent portion (170). To activate the syringe, the valve (110) is actuated and gaseous pressure flows from the reservoir (100) into the expansion chamber (120). Pressure builds up behind the upstream membrane (12) until it reaches a sufficient value to cause the upstream membrane (12) to burst. The gas thereafter entrains the particles and the pressure once again builds up behind downstream membrane (14). Shortly afterwards, the downstream membrane (14) bursts so that the gas (with the particles (13) entrained) can be accelerated in the nozzle (140) and thence into a target (180). - WO 94/24263 discloses that the diaphragm should preferably be heat sealed to the faces of the annular ring. Heat sealing has been found to be a particularly easy and repeatable method of sealing the diaphragms to the ring of the cassette body.
- It has been found that the above-mentioned configuration has a disadvantage associated with its manufacture, which may become especially deleterious when heat-sensitive particles (e.g. powdered drugs) are to be carried by the cassette. After the particles have been supplied to the chamber (11) formed by the annular ring (10) and the bottom membrane (12), the heat sealing of the top membrane (14) onto the ring (10) can sometimes result in a degradation of the particles. This degradation may take the form of melting, causing particle deformation, particle agglomeration and other undesirable physical and chemical changes in the product. Further, the melt may affect the therapeutic effect of the particles.
- Accordingly, the present invention seeks to alleviate this problem by providing a particle cassette, a kit of parts and a method for the manufacture therefor in which the possibility of the particles melting during manufacture is much reduced.
- In accordance with the first aspect of the present invention, there is provided a kit of parts for use in the manufacture of a particle cassette for a needleless syringe device, said kit comprising:
-
- a first cassette part having a first rupturable membrane sealed thereto; and
- a second cassette part having a second rupturable membrane sealed thereto; said first and second cassette parts being arranged to be attachable together so as to create a chamber for the confinement of particles between said first and second membranes.
- Thus, since the membranes are sealed to first and second cassette parts (possibly by heat sealing) before the particles are supplied to either of the cassette parts, there is a much reduced possibility of the membrane heat sealing process influencing the particle condition or composition. Further, the invention provides a quick and easy method of manufacturing a particle cassette and has these advantages over processes which do not involve heat sealing.
- Preferably, the first and second cassette parts are annular such that the second part is attachable concentrically around or inside the first cassette part. This allows the first cassette part to extend substantially along the whole width of the particle cassette making it easier to fill the first part with particles prior to attaching the second part.
- To attach the first and second parts together, a variety of mechanisms may be used, including interference fits, friction fits, screw fits, detents and recesses, close tolerances, gluing etc. A snap fit may be provided for by arranging corresponding features on each of the first and second parts (for example a detent and a recess).
- In order to ensure a consistent width of particle cassette, it is preferable to provide a seating face on each of the first and second parts, such a seating face providing a minimum possible width of particle cassette when assembled.
- A tapered face on each of the first and second parts allows the parts to be brought together easily during assembly.
- A third cassette part may be used to attach the first and second parts together. In a preferred embodiment, the third cassette part is inserted in an annular apace between the first and second cassette parts, to provide a secure attachment (or “locking”). The third part preferably has a third membrane to ensure sterility and may be provided with one or more protrusions to ensure an interference fit with the second cassette part.
- In a second aspect of the invention, there is provided a particle cassette for a needleless syringe comprising an assembled kit according to the first aspect and particles provided in the chamber between the first and second membranes.
- According to a third aspect of the present invention, there is provided a needleless syringe including the particle cassette of the second aspect of the invention.
- According to a fourth aspect of the invention, there is provided a method of assembling a particle cassette for a needleless syringe device, said method comprising:
-
- (a) sealing a first rupturable membrane to a first cassette part;
- (b) sealing a second rupturable membrane to a second cassette part;
- (c) applying particles to said first cassette part;
- (d) attaching said first and second cassette parts together so as to create a chamber confining said supplied particles between said first and second membranes.
- The sealing of the membranes to the cassette parts independently from the steps of supplying particles to one of the cassette parts and attaching the cassette parts together ensures that the method used for sealing the membranes to the cassette parts does not unduly influence the quality of the particles in the cassette.
- Preferably, attaching step (d) does not involve the application of any heat at all and it is preferably carried out at the same temperature as supplying step (c) to ensure that the particles are not affected by the step of attaching the first and second cassette parts together.
- It is not essential that supplying step (c) is carried out after sealing step (b) since the second membrane may be sealed to the second cassette part after the particles have been supplied to the first cassette part.
- Embodiments of the present invention will now be described, by way of example only, with reference to the accompanying schematic drawings, in which:-
-
FIGS. 1 a to 1 d are cross-sectional views showing stages in the manufacture of a particle cassette according to the prior art; -
FIGS. 2 a and 2 b are cross-sectional views showing stages in the manufacture of a particle cassette according to a first embodiment of the invention; -
FIG. 3 is a cross-sectional view showing an assembled particle cassette according to a second embodiment of the present invention; -
FIG. 4 is a cross-sectional view showing an assembled particle cassette according to a third embodiment of the present invention; -
FIG. 5 is a cross-sectional view showing an assembled particle cassette according to a fourth embodiment of the present invention; -
FIG. 6 is a cross-sectional view showing an assembled particle cassette according to a fifth embodiment of the present invention; -
FIG. 7 is a cross-sectional view of a second cassette part according to a sixth embodiment of the present invention; -
FIG. 8 is a cross-sectional view of a first cassette part according to a sixth embodiment of the present invention; -
FIG. 9 is a cross-sectional view along the line A-A shown inFIG. 8 ; -
FIG. 10 is a cross-sectional view of a third cassette part according to a sixth embodiment of the present invention; -
FIG. 11 is a cross-sectional view of an assembled particle cassette according to a sixth embodiment of the present invention; -
FIG. 12 shows two perspective views of a partially cut-away particle cassette according to the sixth embodiment of the present invention. -
FIG. 13 is a set of three orthographic views of an assembled particle cassette according to a seventh embodiment of the present invention; -
FIG. 14 is a set of three orthographic views of an assembled particle cassette according to a eighth embodiment of the present invention; and -
FIG. 15 is a longitudinal cross-sectional view through a needleless syringe which may comprise the particle cassette of any one of the embodiments of the present invention. - In the drawings the components are not drawn to scale. The drawings are schematic for reasons of clarity. In reality the thickness of the rupturable diaphragms may be much less than that shown and/or the volume of particles may be so small as barely to be visible to the naked eye.
- The present invention avoids the possibility of the heat sealing of the membranes affecting the particle quality by ensuring that the particles are confined within the chamber of the cassette by a step other than one involving heat sealing of one of the membranes. Thus, generally speaking, each of the embodiments of the present invention comprises a first cassette part (20) having a first membrane (22) sealed to a face and a second cassette part (21) having a second membrane (23) sealed to a face. Particles (24) are dispensed into the first cassette part and the second cassette part is then attached. The attachment step should not involve the application of an amount of heat such as is likely to damage the particles. However, heat sealing can be used in the attachment step if the heat is used such that the particles are not likely to be damaged.
-
FIGS. 2 a and 2 b show an axi-symmetric cross-section of the particle cassette according to the first embodiment of the present invention. - In the first embodiment, the first cassette part (20) comprises an annular ring having a first face (the upper face in
FIG. 2 a) for attachment to a second cassette part (21), the other side of the annular ring having had a first membrane (22) sealed thereto. The second cassette part (21) is substantially identical to the first cassette part, having had a second membrane (23) sealed thereto. The first and second cassette parts, having the first and second membranes respectively, form a kit of parts for use in the manufacture of the particle cassette. The membranes are sealed to the external faces of the respective cassette parts. If heat sealing is used to attach the membranes then a recess (30,31) as shown inFIG. 2 a is useful because it allows for some plastic deformation as will be caused by heat sealing in general. In particular, the heat causes local expansion of the cassette material and the recesses (30,31) allow the cassette material to expand without affecting the designed gas flow path (eg by restricting the diameter of the flow path). - In order to manufacture the particle cassette, particles (24) are dispensed to the first cassette part (20) and the first (20) and second (21) cassette parts are attached together so as to create a closed chamber for the confinement of the particles (24) between the first (22) and second (23) membranes. The assembled particle cassette is shown in
FIG. 2 b. - In use, the particle cassette is located in a needleless syringe device which may have the general construction, and method of operation, described in WO 94/24263 or WO 01/05455, the contents of which are hereby incorporated by way of reference. When located in the syringe device the device construction is advantageously such as to prevent the first cassette part (20) coming away from the second cassette part (21). However, in order to mitigate against further such. detachment, the second cassette part (21) may be adhered to the first cassette part (20), for example by gluing or by taping around the external circumference of the particle cassette. This provides a sealed unit of particles which can be handled outside of the needleless syringe device with reduced possibility of particles escaping from between the two cassette halves.
- A second embodiment of the invention is shown in
FIG. 3 . The particles (24) are omitted from inside the particle cassette for the sake of clarity. Further, it is to be noted that the particle cassette shown inFIG. 3 (and those shown inFIGS. 4 to 6 as well) will, prior to assembly, make up a kit of parts according to the first aspect of the present invention. - In the second embodiments, the first cassette part (20) is constituted by a substantially annular member which extends to a height X nearly equal to the height Y of the assembled particle cassette. This greatly facilitates the filling of the first cassette part (21) with particles (24) since a larger receptacle than is provided in the first embodiment can be used to receive particles (24). A further advantage is that the whole internal volume of the cassette can be used to hold particles. In contrast, the first embodiment can only be half filled with particles since the first cassette part (20) has a height equivalent only to approximately half the final height of the cassette.
- The second cassette part (21) also has a substantially annular construction and is arranged to be attachable concentrically around the first cassette part (20). If necessary, adhesive can be used at the interface (25) to ensure that the first and second cassette parts do not detatch easily. More preferred, however, is that the cassette parts are attached by an interference fit, whereby the outer diameter of the engaging region of the first cassette part is slightly larger than the inner diameter of the engaging region of the second cassette part (21). In this way, the parts will naturally lock together due to the elastic strain established in each of the first and second cassette parts when the second part (21) is placed around the first part (20).
- The second embodiment shown above has advantages over the first embodiment because it does not necessarily require an extra adhesive to be used (an interference fit is instead used) and because the first cassette part defines a larger receptacle area for receiving the particles (24). However, the second embodiment has the disadvantage that it may be difficult or fiddly to assemble, even if one or both of the engaging inner face of the second cassette part and the engaging outer face of the first cassette part is provided with a lead in taper to aid assembly. To overcome this problem, a cassette according to the third embodiment of the invention is provided. Such a cassette is shown in
FIG. 4 . - In the third embodiment of the present invention, the outer engaging face of the first cassette part (20) and the inner engaging face of the second cassette part (21) (the interface of which is denoted as (26) in
FIG. 4 ) are tapered so as to allow the second cassette part (21) to be easily placed over the first cassette part (20). Again, although gluing may be used to attach the parts, it is preferable that the first cassette part (20) has a larger outer diameter than the inner diameter of the second cassette part (21) at each point along the height of the cassette. This means that as the parts are brought close to the assembled position shown inFIG. 4 , some elastic strain is established in the parts to provide a snug fit. The parts are prevented from coming apart by friction along the tapered interface (26). - The third embodiment of the invention thus has the advantage that it is easier to assemble the kit of parts than the second embodiment of the invention. However, it has the potential disadvantage that the width of the cassette (ie the vertical dimension in
FIG. 4 ) may not necessarily be predicted before the parts are assembled. Depending on the force used to push the first (20) and second (21) cassette parts together, the width may vary over a certain range. For example, if the parts are pressed together very strongly, the width is likely to be less than if the parts are only lightly pressed together. Furthermore, the leading edge of the first cassette part (20) may damage the seal between the second membrane (23) and the second cassette part (21) if the two parts are pushed together too strongly. - To overcome this problem, a particle cassette as shown in the fourth embodiment of the invention is provided.
- In this embodiment, a seating face (27) is provided to each of the first (20) and second (21) cassette parts. As is shown in
FIG. 5 , once the cassette parts have been pushed together a certain amount, the seating face (27) prevents further movement in the cassette height direction (i.e. the vertical direction inFIG. 5 ). The fourth embodiment of the invention therefore allows the width dimension of the assembled particle cassette to be reliably ensured. The tapered sections (26) perform the same function as in the third embodiment and the outer surfaces of the first cassette part (20) may again be made to have a slightly larger diameter than the inner surfaces of the second cassette part (21) so as to provide an interference fit. The steeper angle of the lower taperedsection 26 provides for a better locked fit. The fairly uniform cross-section in the vicinity of the membranes allows for good heat dissipation during the heat sealing process, if used. - While an interference fit is suitable for a lot of purposes, it is often preferable that no elastic strains are built up in the first and second cassette parts, especially if they are to be re-used a lot of times. The fifth embodiment of the invention addresses this problem.
FIG. 6 shows an axi-symmetric cross-sectional view of the fifth embodiment of the invention having parts generally similar to those shown inFIG. 5 . - The main difference is the provision on each of the first (20) and second (21) cassette parts of corresponding features (28, 29) which provide for a snap fit when the first and second cassette parts are brought together. In particular, the first cassette part (20) comprises a detent (28) located on one of external tapered surfaces (26). Correspondingly, the second cassette part (21) comprises a recess (29) on its respective tapered surface (26). Thus, when the first and second cassette parts are brought together, the detent (28) locates in the recess (29) to lock the two pieces together. During this attaching step, both the first and second cassette parts undergo a momentary elastic strain as the detent (28) engages in the recess (29) but, once assembled, the cassette part can be arranged so that there is little residual strain present. This means that there is no requirement to rely on an interference fit alone to maintain the first and second cassette parts in attachment. The provision of corresponding features also makes it more difficult for the first and second parts to be accidentally detached, providing a stronger lock between the first and second cassette parts and thus a more secure sealed environment for the particles. This is particularly useful when the cassette is to be subject to vibrations, such as those experienced during transportation. The fifth embodiment shown in
FIG. 6 is considered to be the best mode of carrying out the invention. - The fifth embodiment has a further advantage in that it provides an assembly that is tamper evident. Once assembled, it is very difficult to prise the cassette parts apart due to the taper lock and detent arrangement. Thus, the assembly could only be opened by destroying one of the membranes or using a very sharp tool to lever apart the parts, which in practice causes obvious deformation of the cassette parts.
-
FIGS. 7 to 12 show a sixth embodiment of the invention. Unlike the previous embodiments, the particle cassette of the sixth embodiment has three main component parts rather than two. -
FIGS. 7 and 8 show in cross-sectional view second and first cassette parts respectively. The second cassette part (30) ofFIG. 7 is generally cylindrical in configuration having substantially vertical inside walls (33) and ( 34). The inside wall (33) has a slightly smaller diameter than inside wall (34) for reasons that will become apparent later. A shoulder portion (31) is provided adjacent a seating face (32). The shoulder portion (31) is designed to interact with the external surface of the first cassette part (40), described hereafter. A recess (35) is provided at the top end of the second cassette part (30) and this recess (35) aids in assembling the cassette. -
FIG. 8 shows a first cassette part (40) according to the sixth embodiment of the present invention. The first cassette part (40) comprises a substantially annular member defining within its confines a receptacle for receiving particles. The first cassette part (40) has generally cylindrical outer walls (42) and a slightly tapered seating face (41) at its bottom end. The seating face (41) is intended to rest against the seating face (32) of the second cassette part (30) during use. Furthermore, the shoulder (31) of the second cassette part (30) is intended to abut the outer surface (42) of the first cassette part to provide an interference fit. This configuration is shown inFIG. 11 . - Referring back to
FIGS. 8 and 9 , there are openings (43) on the inner surface of the first cassette part (40) and openings (44) on the outer surface of the first cassette part (40). These openings are connected by transfer ducts such that gas surrounding the first cassette part (40) may enter the receptacle for receiving particles. The transfer ducts are substantially conical and are angled in three dimensions such that when gas flows therethrough a sonic jet is formed which tends to create a swirling gas movement inside the chamber confining the particles. The transfer ducts are angled such that the gas tends to impinge against the membranes located at either side of the first cassette part (40). Furthermore, the holes (43) are provided at different longitudinal ends of the first cassette part (40) and are directed in different directions such that a clockwise gas flow is established at one end of the particle confinement chamber and an anti-clockwise gas flow is established at the other end of the particle confinement chamber. This is illustrated inFIG. 12 wherein the gas flows are referenced (65) and (66). As is clear fromFIG. 9 , the transfer ducts are provided on the same lateral side of the first cassette part (i.e. above the centre line shown inFIG. 9 ), and this has been found to provide for good fluidization of the particles when gas pressure is introduced to the openings (44) and a flow of gas is established through the transfer ducts. However, other configurations of transfer duct in the side walls of the first particle cassette part (40) can provide good results and it is not generally essential for the present invention that the transfer ducts have the specific form shown inFIGS. 8 and 9 . -
FIG. 10 shows a third particle cassette part in accordance with the sixth embodiment of the present invention. - The third cassette part (50), in common with the first and second cassette parts, has generally cylindrical inner and outer walls forming an annular-shaped member. One or more protrusions (51) may be formed on the outer walls and these are intended to provide an interference fit against the inner wall (34) of the second cassette part (30), when the particle cassette is assembled. The lower end of the third cassette part (50) has a number of formations (52) around the circumference. The formations (52) are stepped and are designed such that the top part (53) of the formations (52) abuts the top surface of the first cassette part (40) when assembled, as shown in
FIG. 11 . The formations are spaced apart by vent holes (54) that are formed such that gas may pass through the vent holes (54) when the first and third cassette parts are attached together. The formations (52) are shaped so as to grip, by means of friction, or interference, the top part of the first cassette part (40). - The particle cassette according to the sixth embodiment of the invention takes the form shown in
FIG. 11 when assembled. In this embodiment, there are three membranes (61, 62, 63) of which one membrane (61) is relatively thin with a fairly low bursting pressure and is designed to keep the unit sterile in use. - To assemble the particle cassette of the sixth embodiment, a first membrane (62) is heat sealed or bonded to the upper edge of the first cassette part (40). Similarly, the second membranes (63) is heat sealed or bonded to the seating face (32) of the second cassette part (30). The third membrane (61) is heat sealed or bonded to the upper face of the third cassette part (50). The first membrane and first cassette part thus define a receptacle in which the particles may be contained. The openings (43) are very small such that it is very difficult for the particles to pass out of the chamber once inside. Once the particles have been supplied to the chamber of the first cassette part (40), the first cassette part (40) is brought together with the second cassette part (30) with the leading edge of the first cassette part engaging the shoulders (31) of the second cassette part. The first cassette part (40) is pushed home until the seating face (41) of the first cassette part abuts the seating face (32) of the second cassette part (with the second membrane (63) between the two seating faces). In this configuration, the particles are trapped between the first and second membranes. The third cassette part (50) having the third membrane (61) thereon is then pushed in so that the formations (52) slide into the annular gap created between the first and second cassette parts. Interference and/or friction ensure that this movement firmly secures the first and second parts together and effectively “locks” the cassette. It will be appreciated that it is quite difficult to remove the third cassette part once it is installed, especially if the top face (55) of the third cassette part is dimensioned so as to be flush with the top face of the second cassette part when assembled (this is not shown in
FIG. 11 however). - The membrane (61) ensures that the particles inside the cassette may not come into contact with any external particles or gases and thus the membrane (61) ensures the sterility of the cassette.
- In use, the cassette is inserted into a needleless syringe and gas pressure is supplied to the third membrane (61). The membrane (61) bursts quite easily and gas enters the internal space defined by the third cassette part. Gas is able to flow through the vents (54) and into the annular space (67) between the first cassette part and the second cassette part. From there, gas may pass through the transfer ducts and out through, the openings (43) into the particle containment. The jets of gas so formed cause the particles to be fluidized and mixed. Following that, the upstream membrane (62) bursts and the particles are entrained in the bulk of the gas flow followed by the bursting of the downstream membrane (63) shortly thereafter. In this way, the particle cassette of the sixth embodiment provides for pre-mixing and fluidizing of the particles whilst still overcoming the problem that heat sealing of membranes can damage particles when a single piece cassette is used.
- The concepts described in relation to the first to fifth embodiments may also be applied to the sixth embodiment in the same way. For example, a snap fit may be provided for if detents and corresponding recesses are provided on either the first and second, first and third or second and third cassette parts respectively.
- Heat sealing or adhesive is not necessary in the sixth embodiment and the first and second membranes may be sealed against the first and second cassette parts respectively due to the tight fit between the various cassette parts. For example, the first membrane (62) may be sealed by virtue of being trapped between the first and third cassette parts. Similarly, the second membrane (63) may be trapped between the first and second cassette parts, with no special heat sealing or adhesive step being required.
- As can be seen from
FIG. 15 in particular, the first to sixth embodiments are usually used in a configuration such that the particle cassette is located downstream of an expansion chamber (120) in the needleless syringe. The syringe is therefore complex to assemble. - To overcome this problem, a particle cassette as shown in the seventh and eighth embodiments of the invention is provided. The particle cassette itself has a built in expansion chamber (120) meaning that the syringe has less components overall. This results in a decrease in manufacturing time and complexity.
- The seventh embodiment of the invention is shown in
FIG. 13 . In this embodiment, the first cassette part (70) has heat sealed to a lower edge a membrane (71). Particles are then located in chamber (77) formed by the inner side walls of the first cassette part (70) and the membrane (71). The second cassette part (72) can then be placed on top of the first cassette part so as to seal off chamber (77). As can be seen fromFIG. 13 , the second cassette part (72) comprises a substantially annular member having a membrane (73) attached (eg. by heat sealing) to its lower edge. The annular second member fits inside part of the annular first member. The second member is locked against the first member by means of ribs (74) on the second member which locate in spaces (75) created between the first and second members during assembly. As can be seen, the ribs (74) have a tapered front edge to aid assembly and are made so as to provide a snug interference fit with the inside annular surface (78) of the first member. - It will also be apparent from
FIG. 13 that this embodiment comprises an open chamber (76) that is arranged to open outwardly of the assembled cassette. The chamber (76) lies above (i.e. upstream of) the membrane (73) which separates it from the particle confinement chamber (77). When the cassette is assembled in the finished syringe, the chamber (76) performs the function of the expansion chamber (120) shown inFIG. 15 . Please note thatFIG. 15 is schematic so that, even thoughFIG. 15 shows an expansion chamber (120) which diverges in the downstream direction, the expansion chamber provided by chamber (76) of the particle cassette of the seventh embodiment converges in the downstream direction and this results in a needleless syringe which works adequately. - It can be seen that the particle cassette of the seventh embodiment retains the advantages of the previous embodiments in that the particles can be located in chamber (77) and the two cassette parts pressed together to confine the particles in a chamber, without the need to subject the particles to the heating that often accompanies sealing the membranes to the cassette parts. Furthermore, the seventh embodiment integrates part of the needleless syringe, viz, the expansion chamber (120), with the particle cassette, thereby reducing the number of components and the manufacturing time and expense.
- An eighth embodiment of the invention is shown in
FIG. 14 . The eighth embodiment has a construction very similar to that of the seventh embodiment, save for the particular manner in which the first cassette part (80) is connected to the second cassette part (82). Whilst in the seventh embodiment the two parts are pushed together to form an interference fit, the two parts are screwed together in the eighth embodiment by means of threads (84 and 85). A thread (84) is located on the outer surface of the second cassette part (82) and is designed to mate with a corresponding thread (85) located on the inner surface of first cassette part (80). - It will be apparent from both
FIGS. 13 and 14 that the first cassette part (70 or 80) contains annular longitudinal protrusions which extend beyond the plane of the upstream membrane (73 or 83) in use. These protrusions allow the first part (70 or 80) to be connected to the respective second part (72 or 82) either by means of an interference fit as shown inFIG. 13 , or by means of a screw thread as shown inFIG. 14 . - The screw thread is preferably relatively coarse such that the first and second cassette parts can be connected together with relatively few turns. Preferably, less than one turn of relative movement is necessary, more preferably 180° or less of relative rotation. In the most preferred embodiment, a range of movement between 45° and 120°, preferably 90° is sufficient to attach the first and second cassette parts together.
- Of course, the various means for attaching the cassette parts shown in the first to seventh embodiments may be combined with the features of the eighth embodiment, for example, seating faces, tapers and detents which provide a “snap-fit” can all be used in combination with the screw thread attachment. Furthermore, a third cassette part may be used in the seventh and eighth embodiments to lock the first and second cassette parts together.
- It will be noted from
FIG. 14 that two indents (88) are provided on the outer circumferential surface of the second cassette part (82). These indents are designed to receive a tool which assists in applying a torque to the second cassette part (82) when it is screwed to the first cassette part (80). Similar indents may also be provided on the first cassette part (80) if required. - The screw thread design of the eighth embodiment has been found to give a more reproducible face seal between the mating surfaces of the first and second cassette parts. This helps to prevents egress of payload from the chamber (87) inside the assembled cassette, and gives a more consistent barrier to potential biological contamination. Furthermore, the integration of the expansion chamber (120) with the particle cassette makes the overall dimensions of the cassette larger than in the prior art which facilitates handling and manipulation during manufacture of the needleless syringe comprising the casssette.
- It is envisaged that other embodiments falling within the scope of the present claims can be provided by using combinations of the various attaching methods disclosed in the first to eighth embodiments herein. The type of attaching means to be used depends on the circumstances. For example, there are occasions when a “snap-fit” action is not suitable because the snapping provides a vibrational jolt to the cassette assembly which may damage particularly fragile particles. In such cases, an interference fit or screw fit is preferred.
- For each of the embodiments, the materials used to manufacture the cassette parts and the membranes may be conventional, for example, the membranes may be Mylar as disclosed in WO 94/24263 and the first and second cassette parts are preferably manufactured from a plastics material, using injection moulding for example. Both the membranes and cassette parts may be made from polycarbonate such as Evaxone 260 (EVA) polymer. If heat sealing is used, a temperature of 110° C. and pressure of 760 kPa (110 psi) for 1.5 seconds has been found to be acceptable.
- The cassette is suitable for any type of particle that one intends to deliver, including powdered drugs (therapeutics, medicaments, vaccines, anaesthetics, analgesics, and the like), diagnostic particles (whether inert or comprising an active ingredient), and carrier particles coated with peptides, proteins or genetic material.
Claims (24)
1. A kit of parts for use in the manufacture of a self-contained particle cassette for a needleless syringe device, said kit comprising:
a first cassette part having a first rupturable membrane sealed thereto; and
a second cassette part having a second rupturable membrane sealed thereto,
wherein said first and second cassette parts are arranged to be attached together by a method other than heat sealing so as to form the self-contained particle cassette and so as to create a chamber for the confinement of particles between said first and second membranes.
2. A kit according to claim 1 , wherein said first cassette part is substantially annular and defines a receptacle for receiving particles.
3. A kit according to claim 2 , wherein said second cassette part is substantially annular and is attachable concentrically around or inside said first cassette part.
4. A kit according to claim 1 , wherein said first and second cassette parts are arranged to be attached together by an interference fit.
5. A kit according to claim 1 , wherein said first and second cassette parts each comprise corresponding features which provide for a snap fit when said first and second cassette parts are attached together.
6. A kit according to claim 5 , wherein said corresponding features comprise a detent and a recess.
7. A kit according to claim 1 , wherein said first and second cassette parts each comprise a seating face which ensures attainment of a predetermined dimension of said cassette in the direction in which said first and second cassette parts are attachable together.
8. A kit according to claim 1 , wherein said first and second cassette parts each comprise a tapered face which are arranged to contact one another fully when said cassette is properly assembled.
9. A kit according to claim 5 , wherein said corresponding features are provided on tapered faces which are arranged to contact one another fully when said cassette is properly assembled.
10. A kit according to claim 1 , further comprising a third cassette part adapted to lock together said first and second cassette parts.
11. A kit according to claim 10 , wherein said third cassette part has a third membrane sealed thereto.
12. A kit according to claim 10 , wherein said third cassette part comprises a protrusion adapted to create an interference fit with said second cassette part.
13. A kit according to claim 1 , wherein said first find second cassette parts are shaped so as to be fitted together leaving an annular gap around said first cassette part.
14. A kit according to claim 10 , wherein said first and second cassette parts are shaped so as to be fitted together leaving an annular gap around said first cassette part, and wherein said third cassette part has a portion which inserts into said annular gap so as to lock said first, second and third cassette parts together.
15. A kit according to claim 1 , wherein said first cassette part comprises at least one transfer duct for supplying gas to said particle confinement chamber.
16. A kit according to claim 10 , wherein said third cassette part comprises gas ports for supplying gas to an annular space around said first cassette part.
17. A kit according to claim 1 , wherein said first und second cassette parts are arranged to be attached by a screw thread.
18. A kit according to claim 17 , wherein said screw thread has a coarse pitch such that the first and second cassette parts can be attached together by a relative rotation of 180° or less.
19. A kit according to claim 1 , wherein one of said first and second cassette parts comprises an open chamber that is arranged to open outwardly of the assembled cassette when the first and second cassette parts are attached together.
20. A particle cassette for a needleless syringe comprising:
an assembled kit of the parts claimed in claim 1 ; and
particles provided in said chamber between said first and second membranes.
21. A particle cassette according to claim 20 , wherein said particles comprise powdered drug.
22. A device, comprising:
a needleless syringe including the particle cassette of claim 20 .
23. A kit according to claim 2 , wherein said second cassette part is substantially annular and is attachable concentrically around and/or inside said first cassette part.
24. A kit according to claim 17 , wherein said screw thread has a coarse pitch such that the first and second cassette parts can be attached together by a relative rotation of about 180° or less.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/071,324 US20080300535A1 (en) | 2001-07-26 | 2008-02-20 | Particle cassette, method and kit therefor |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30798601P | 2001-07-26 | 2001-07-26 | |
PCT/GB2002/003395 WO2003011379A1 (en) | 2001-07-26 | 2002-07-25 | Particle cassette, method and kit therefor |
US10/484,751 US8061006B2 (en) | 2001-07-26 | 2002-07-25 | Particle cassette, method and kit therefor |
US12/071,324 US20080300535A1 (en) | 2001-07-26 | 2008-02-20 | Particle cassette, method and kit therefor |
Related Parent Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2002/003395 Continuation WO2003011379A1 (en) | 2001-07-26 | 2002-07-25 | Particle cassette, method and kit therefor |
US10/484,751 Continuation US8061006B2 (en) | 2001-07-26 | 2002-07-25 | Particle cassette, method and kit therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080300535A1 true US20080300535A1 (en) | 2008-12-04 |
Family
ID=44947274
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/484,751 Expired - Fee Related US8061006B2 (en) | 2001-07-26 | 2002-07-25 | Particle cassette, method and kit therefor |
US12/071,324 Abandoned US20080300535A1 (en) | 2001-07-26 | 2008-02-20 | Particle cassette, method and kit therefor |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/484,751 Expired - Fee Related US8061006B2 (en) | 2001-07-26 | 2002-07-25 | Particle cassette, method and kit therefor |
Country Status (1)
Country | Link |
---|---|
US (2) | US8061006B2 (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090088508A1 (en) * | 2003-07-25 | 2009-04-02 | Degussa Ag | Powdery composition of a polymer and a flameproofing agent containing ammonium polyphosphate, method for the production thereof, and moulded body produced from said powder |
US20100298767A1 (en) * | 2006-06-09 | 2010-11-25 | Bates Nigel Robert | Particle Cassettes |
USRE43824E1 (en) | 2001-01-11 | 2012-11-20 | Powder Pharmaceuticals Inc. | Needleless syringe |
US8388569B2 (en) | 2011-04-19 | 2013-03-05 | Xerox Corporation | Delivery devices and methods with collimated gas stream and particle source |
US8430839B2 (en) | 2011-04-19 | 2013-04-30 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and drug reservoir |
US8486002B2 (en) | 2011-04-19 | 2013-07-16 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and release-activatable tape |
US8540665B2 (en) | 2007-05-04 | 2013-09-24 | Powder Pharmaceuticals Inc. | Particle cassettes and processes therefor |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10279113B2 (en) * | 2013-05-17 | 2019-05-07 | Socpra Sciences Et Genie S.E.C. | Needleless syringe and method for delivering therapeutic particles |
AU2015222937B2 (en) * | 2014-02-26 | 2017-03-30 | Powder Pharmaceuticals Incorporated | Device for delivering particles |
Citations (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US533505A (en) * | 1895-02-05 | Barrel-support | ||
US1300654A (en) * | 1919-01-30 | 1919-04-15 | William H Rose | Dry-spraying machine. |
US1434460A (en) * | 1922-02-21 | 1922-11-07 | Tibbatts James | Metallic nursing bottle |
US1774258A (en) * | 1929-07-08 | 1930-08-26 | Raymond A English | Duplex capsule or the like |
US1861047A (en) * | 1929-05-13 | 1932-05-31 | Parke Davis & Co | Sealed capsule |
US2147158A (en) * | 1937-09-28 | 1939-02-14 | Goldenthal Philip | Powder insufflator |
US2151418A (en) * | 1937-05-12 | 1939-03-21 | Scott & Bowne | Powder applicator |
US2307986A (en) * | 1940-02-15 | 1943-01-12 | Bolte | Insufflator |
US2314527A (en) * | 1940-07-06 | 1943-03-23 | Atlantic Coast Fisheries Co | Method of making sealed capsules |
US2470298A (en) * | 1949-02-07 | 1949-05-17 | Abbott Lab | Powdered medicine dispenser |
US2478715A (en) * | 1948-07-14 | 1949-08-09 | Vilbiss Co | Powder blower |
US2594093A (en) * | 1949-02-05 | 1952-04-22 | Armour & Co | Powder container |
US3216562A (en) * | 1963-06-13 | 1965-11-09 | Driaire Inc | Easy-open capsule |
US3324902A (en) * | 1965-05-26 | 1967-06-13 | Bartelt Engineering Co Inc | Method of filling capsules |
US3508677A (en) * | 1968-08-20 | 1970-04-28 | Whittaker Corp | Vessel for storing high-pressure gases |
US3659600A (en) * | 1970-02-24 | 1972-05-02 | Estin Hans H | Magnetically operated capsule for administering drugs |
US3664495A (en) * | 1970-12-21 | 1972-05-23 | Parke Davis & Co | Locking capsule |
US3674028A (en) * | 1969-06-04 | 1972-07-04 | Ims Ltd | Multi-mix |
US3735761A (en) * | 1971-02-11 | 1973-05-29 | Ampoules Inc | Hypodermic devices |
US3736933A (en) * | 1970-12-02 | 1973-06-05 | B Szabo | Burstable seamed hypodermic applicators |
US3782380A (en) * | 1973-01-04 | 1974-01-01 | Gaast H V D | Medicament injecting device |
US3788315A (en) * | 1971-04-20 | 1974-01-29 | S Laurens | Disposable cutaneous transjector |
US3797490A (en) * | 1971-02-11 | 1974-03-19 | Ampoules Inc | Hypodermic ampoule with skin tensioning clip |
US3797491A (en) * | 1971-02-11 | 1974-03-19 | Ampoules Inc | Method of performing an intramuscular injection |
US3810469A (en) * | 1972-05-24 | 1974-05-14 | Ampoules Inc | Multiple compartment hypodermic devices |
US3967761A (en) * | 1974-04-08 | 1976-07-06 | Southwest Research Institute | System for injecting particulate material into the combustion chamber of a repetitive combustion coating apparatus |
US4031892A (en) * | 1974-07-18 | 1977-06-28 | Ampoules Corporation | Two-chamber mixing syringe |
US4081077A (en) * | 1977-01-13 | 1978-03-28 | Minnesota Mining And Manufacturing Company | Compartmented package |
US4226236A (en) * | 1979-05-07 | 1980-10-07 | Abbott Laboratories | Prefilled, vented two-compartment syringe |
US4360969A (en) * | 1978-09-22 | 1982-11-30 | Bicc Limited | Chain of electrical connector housings and a method of fitting a housing to an electrical contact |
US4416370A (en) * | 1982-08-25 | 1983-11-22 | Robert Beall | Compartmented container |
US4474303A (en) * | 1981-08-28 | 1984-10-02 | Maccise Adiv Y | Portable modular food container |
US4515586A (en) * | 1982-11-30 | 1985-05-07 | Abbott Laboratories | Powder syringe mixing system |
US4517815A (en) * | 1983-10-07 | 1985-05-21 | Basso Peter J | Insulated modular cooler |
US4581875A (en) * | 1983-06-20 | 1986-04-15 | Cosden Technology, Inc. | Process for forming tamper-resistant tamper-indicative capsules |
US4596556A (en) * | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4703863A (en) * | 1986-08-21 | 1987-11-03 | Kohusmariol Inc. | Baby feeding bottle assembly |
US4738817A (en) * | 1983-11-17 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from hydrophilic polymers |
US4774085A (en) * | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
US4778068A (en) * | 1987-11-24 | 1988-10-18 | Kohusmariol Inc. | Baby-feeding bottle |
US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
US4811731A (en) * | 1985-07-30 | 1989-03-14 | Glaxo Group Limited | Devices for administering medicaments to patients |
US4852757A (en) * | 1988-04-21 | 1989-08-01 | Milton Gold | Adapter for expanding the volume of a container |
US4858759A (en) * | 1985-12-21 | 1989-08-22 | Hilti Aktiengesellschaft | Container arrangement for cartridge dispensing two-component mass |
US4863017A (en) * | 1988-11-09 | 1989-09-05 | Vlock D G | Amalgam capsule |
US4893721A (en) * | 1982-10-29 | 1990-01-16 | Warner-Lambert Company | Tamper-proof capsules |
US4910866A (en) * | 1989-02-21 | 1990-03-27 | Micron Technology, Inc. | Method of manufacturing a series of leadframe strip carriers having fixed external dimensions and varied internal dimensions using a common mold |
US4939827A (en) * | 1987-10-20 | 1990-07-10 | Diado Metal Company Ltd. | Method of manufacturing a bearing device including a housing with a flange at one end thereof and a bearing bush press-fitted thereinto |
US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US4966581A (en) * | 1988-04-22 | 1990-10-30 | Vitajet Industria E. Commercio Ltda | Non reusable disposable capsule containing an individual vaccine dose to be hypodermically injected with a pressure needleless injection apparatus |
US4991377A (en) * | 1988-09-19 | 1991-02-12 | Massimo Marchesini | Method for the mutual joining of the cap and the body of a capsule used to enclose medicines and apparatus which carries out this method |
US5036006A (en) * | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US5042472A (en) * | 1990-10-15 | 1991-08-27 | Merck & Co., Inc. | Powder inhaler device |
US5046618A (en) * | 1990-11-19 | 1991-09-10 | R. P. Scherer Corporation | Child-resistant blister pack |
US5053389A (en) * | 1986-04-18 | 1991-10-01 | Per Balschmidt | Insulin preparation for non-parenteral administration |
US5062830A (en) * | 1990-04-04 | 1991-11-05 | Derata Corporation | Dry disposable nozzle assembly for medical jet injector |
USRE33801E (en) * | 1986-05-09 | 1992-01-21 | Dentsply Research & Development Corp. | Mixing and discharge capsule |
US5100792A (en) * | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
US5102388A (en) * | 1991-07-15 | 1992-04-07 | Richmond John E | Sequential delivery syringe |
US5120657A (en) * | 1986-12-05 | 1992-06-09 | Agracetus, Inc. | Apparatus for genetic transformation |
US5141496A (en) * | 1988-11-03 | 1992-08-25 | Tino Dalto | Spring impelled syringe guide with skin penetration depth adjustment |
US5149655A (en) * | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
US5179022A (en) * | 1988-02-29 | 1993-01-12 | E. I. Du Pont De Nemours & Co. | Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner |
US5188615A (en) * | 1990-11-19 | 1993-02-23 | Habley Medical Technology Corp. | Mixing vial |
US5204253A (en) * | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
US5207217A (en) * | 1990-07-16 | 1993-05-04 | Promo Pack Sa | Multiple single-dose inhaler for medicaments in powder form |
US5228573A (en) * | 1991-04-23 | 1993-07-20 | Richard Pavelle | Pharmaceutical capsule and method of making |
US5239991A (en) * | 1989-06-21 | 1993-08-31 | Fisons Plc | Disposable powder medicament inhalation device with peel-off cover |
US5256142A (en) * | 1991-08-06 | 1993-10-26 | Sicim Spa | Injector administering subcutaneous injections without a needle and with a one-shot cap |
US5349947A (en) * | 1993-07-15 | 1994-09-27 | Newhouse Michael T | Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow |
US5394980A (en) * | 1987-06-30 | 1995-03-07 | Tsai; Min H. | Multicompartment mixing capsule |
US5415162A (en) * | 1994-01-18 | 1995-05-16 | Glaxo Inc. | Multi-dose dry powder inhalation device |
US5422129A (en) * | 1994-04-11 | 1995-06-06 | Draddy; John G. | Dispensing display container and particulate coffee therein |
US5492112A (en) * | 1991-05-20 | 1996-02-20 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5560490A (en) * | 1992-09-09 | 1996-10-01 | Fisons Plc | Pharmaceutical packaging with capsule sealing means |
US5630796A (en) * | 1993-04-08 | 1997-05-20 | Oxford Biosciences Limited | Method of delivering powder transdermally with needless injector |
US5658892A (en) * | 1993-01-15 | 1997-08-19 | The General Hospital Corporation | Compound delivery using high-pressure impulse transients |
US5865796A (en) * | 1994-01-21 | 1999-02-02 | Powderject Vaccines, Inc | Gas driven gene delivery instrument |
US5899880A (en) * | 1994-04-08 | 1999-05-04 | Powderject Research Limited | Needleless syringe using supersonic gas flow for particle delivery |
US5947928A (en) * | 1997-06-19 | 1999-09-07 | Mile Creek Capital, Llc | Drug delivery system |
US6010478A (en) * | 1995-02-14 | 2000-01-04 | Powderject Research Limited | Trans-mucosal particle delivery |
US6013050A (en) * | 1995-10-20 | 2000-01-11 | Powderject Research Limited | Particle delivery |
US6276547B1 (en) * | 2000-06-09 | 2001-08-21 | Thomas M. Petryna | Food containers with detachable and discardable sections |
US20010015326A1 (en) * | 2000-02-21 | 2001-08-23 | Coltene Ag | Container for receiving a filling product and a method for its manufacture |
US6592545B1 (en) * | 1994-12-23 | 2003-07-15 | Powderject Research Limited | Particle delivery |
US6923800B2 (en) * | 1997-07-25 | 2005-08-02 | Alza Corporation | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
US6929005B2 (en) * | 2001-01-12 | 2005-08-16 | Becton, Dickinson And Company | Medicament respiratory delivery device, cartridge and method of making same |
US6949154B2 (en) * | 2001-07-28 | 2005-09-27 | Boehringer Ingelheim Pharma Kg | Method and apparatus for sealing medicinal capsules |
US6953039B2 (en) * | 1998-05-05 | 2005-10-11 | Trudell Medical International | Medicament dispensing device |
US7014651B2 (en) * | 1999-03-11 | 2006-03-21 | Alsius Corporation | Method and system for treating cardiac arrest using hypothermia |
US7044134B2 (en) * | 1999-11-08 | 2006-05-16 | Ev3 Sunnyvale, Inc | Method of implanting a device in the left atrial appendage |
US7121402B2 (en) * | 2003-04-09 | 2006-10-17 | Reactive Nano Technologies, Inc | Container hermetically sealed with crushable material and reactive multilayer material |
US20070185450A1 (en) * | 2006-02-01 | 2007-08-09 | Marco De Polo | Self-sealing connection for housing shells of an administering device |
US20090110723A1 (en) * | 2007-10-15 | 2009-04-30 | Mcallister Stephen Mark | Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms |
US7562771B2 (en) * | 2000-10-25 | 2009-07-21 | Lameplast S.P.A. | Bottle for two-component extemporaneous products |
US7691407B2 (en) * | 1999-07-30 | 2010-04-06 | Smithkline Beecham Plc | Multi-component pharmaceutical dosage form |
Family Cites Families (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US565799A (en) * | 1896-08-11 | Hat and coat tree | ||
US656527A (en) * | 1899-11-20 | 1900-08-21 | Andrew Dinkel | Chuck. |
US1873372A (en) * | 1930-03-19 | 1932-08-23 | Universal Button Fastening & B | Button |
GB677523A (en) | 1948-04-13 | 1952-08-20 | Becton Dickinson Co | Discharge structure for hypodermic injection device |
DE1047385B (en) | 1952-03-08 | 1958-12-24 | Armour & Co | Powder atomizer with an exchangeable powder container |
JPS50101521A (en) | 1974-01-17 | 1975-08-12 | ||
US3954098A (en) * | 1975-01-31 | 1976-05-04 | Dick Donald E | Synchronized multiple image tomographic cardiography |
FR2360031A1 (en) | 1976-07-27 | 1978-02-24 | Klein Max | Silenced gas spray for examination of ear - has supple tube attached to an aerosol and filled with foam which allows laminar flow of gas and reduces noise |
US4180173A (en) * | 1977-12-13 | 1979-12-25 | Raychem Corporation | Tamper-proof closure system |
AU531096B2 (en) * | 1979-04-10 | 1983-08-11 | Jeffrey James Cheetham | Container for dental amalgams |
US4273128A (en) * | 1980-01-14 | 1981-06-16 | Lary Banning G | Coronary cutting and dilating instrument |
US4627432A (en) | 1982-10-08 | 1986-12-09 | Glaxo Group Limited | Devices for administering medicaments to patients |
US4574807A (en) * | 1984-03-02 | 1986-03-11 | Carl Hewson | Method and apparatus for pacing the heart employing external and internal electrodes |
US4669469A (en) * | 1986-02-28 | 1987-06-02 | Devices For Vascular Intervention | Single lumen atherectomy catheter device |
US4728319A (en) * | 1986-03-20 | 1988-03-01 | Helmut Masch | Intravascular catheter |
US5167228A (en) * | 1987-06-26 | 1992-12-01 | Brigham And Women's Hospital | Assessment and modification of endogenous circadian phase and amplitude |
GB2206794A (en) | 1987-07-14 | 1989-01-18 | Richard Kiteley Power | Syringe |
US4853229A (en) | 1987-10-26 | 1989-08-01 | Alza Corporation | Method for adminstering tiny pills |
US4909781A (en) * | 1988-04-08 | 1990-03-20 | Husted Royce Hill | Catheter with flexible cutter |
US6730105B2 (en) * | 1988-07-29 | 2004-05-04 | Samuel Shiber | Clover leaf shaped tubular medical device |
US4896669A (en) * | 1988-08-31 | 1990-01-30 | Meadox Medicals, Inc. | Dilatation catheter |
US5091205A (en) * | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
US4986807A (en) * | 1989-01-23 | 1991-01-22 | Interventional Technologies, Inc. | Atherectomy cutter with radially projecting blade |
US4950277A (en) * | 1989-01-23 | 1990-08-21 | Interventional Technologies, Inc. | Atherectomy cutting device with eccentric wire and method |
HU200699B (en) | 1989-07-05 | 1990-08-28 | Gyula Erdelyi | Neddleless hypodermic syringe particularly for blinds and poor-sighted persons |
US5282484A (en) * | 1989-08-18 | 1994-02-01 | Endovascular Instruments, Inc. | Method for performing a partial atherectomy |
US5226909A (en) * | 1989-09-12 | 1993-07-13 | Devices For Vascular Intervention, Inc. | Atherectomy device having helical blade and blade guide |
US5100425A (en) * | 1989-09-14 | 1992-03-31 | Medintec R&D Limited Partnership | Expandable transluminal atherectomy catheter system and method for the treatment of arterial stenoses |
US5030201A (en) * | 1989-11-24 | 1991-07-09 | Aubrey Palestrant | Expandable atherectomy catheter device |
US5178625A (en) * | 1989-12-07 | 1993-01-12 | Evi Corporation | Catheter atherotome |
GB9011588D0 (en) | 1990-05-24 | 1990-07-11 | Wellcome Found | Prostaglandin analogues for use in medicine |
US5181920A (en) * | 1990-06-08 | 1993-01-26 | Devices For Vascular Intervention, Inc. | Atherectomy device with angioplasty balloon and method |
US5431688A (en) * | 1990-06-12 | 1995-07-11 | Zmd Corporation | Method and apparatus for transcutaneous electrical cardiac pacing |
US5320634A (en) * | 1990-07-03 | 1994-06-14 | Interventional Technologies, Inc. | Balloon catheter with seated cutting edges |
US5196024A (en) * | 1990-07-03 | 1993-03-23 | Cedars-Sinai Medical Center | Balloon catheter with cutting edge |
GB9016789D0 (en) | 1990-07-31 | 1990-09-12 | Lilly Industries Ltd | Medicament administering devices |
WO1992004439A1 (en) | 1990-08-30 | 1992-03-19 | Brian John Bellhouse | Ballistic apparatus |
US5112900A (en) * | 1990-11-28 | 1992-05-12 | Tactyl Technologies, Inc. | Elastomeric triblock copolymer compositions and articles made therewith |
DK288590D0 (en) | 1990-12-04 | 1990-12-04 | Michael Morris | MIXTURE / SOLUTION SPRAY FOR CYTOSTATICS FOR MEDICAL TREATMENT OF CANCER PATIENTS |
GB9100950D0 (en) | 1991-01-16 | 1991-02-27 | Dunne Miller Weston Ltd | Metered dose atomising and delivery device |
US5360410A (en) | 1991-01-16 | 1994-11-01 | Senetek Plc | Safety syringe for mixing two-component medicaments |
GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
FR2682088B1 (en) * | 1991-10-04 | 1994-06-10 | Emballages Conditionnement | PACKAGING FOR THE EXTEMPORANEOUS PREPARATION OF MEDICINAL PRODUCTS. |
US5224945A (en) * | 1992-01-13 | 1993-07-06 | Interventional Technologies, Inc. | Compressible/expandable atherectomy cutter |
US5192291A (en) * | 1992-01-13 | 1993-03-09 | Interventional Technologies, Inc. | Rotationally expandable atherectomy cutter assembly |
US5226887A (en) * | 1992-02-07 | 1993-07-13 | Interventional Technologies, Inc. | Collapsible folding angioplasty balloon |
EP0558879B1 (en) | 1992-03-04 | 1997-05-14 | Astra Aktiebolag | Disposable inhaler |
US5176693A (en) * | 1992-05-11 | 1993-01-05 | Interventional Technologies, Inc. | Balloon expandable atherectomy cutter |
US5527325A (en) * | 1993-07-09 | 1996-06-18 | Device For Vascular Intervention, Inc. | Atherectomy catheter and method |
SE506086C2 (en) * | 1994-04-05 | 1997-11-10 | Groena J Ab | Compost containers composed of annular elements |
US5483954A (en) | 1994-06-10 | 1996-01-16 | Mecikalski; Mark B. | Inhaler and medicated package |
GB9416663D0 (en) | 1994-08-17 | 1994-10-12 | Oxford Bioscience Limited | Particle delivery |
US5474195A (en) * | 1995-01-24 | 1995-12-12 | Pai; Ming Y. | Built-up basket |
US5728123A (en) * | 1995-04-26 | 1998-03-17 | Lemelson; Jerome H. | Balloon actuated catheter |
US5766203A (en) * | 1995-07-20 | 1998-06-16 | Intelliwire, Inc. | Sheath with expandable distal extremity and balloon catheters and stents for use therewith and method |
US5792158A (en) * | 1995-11-15 | 1998-08-11 | Lary; Banning Gray | University dilator with expandable incisor |
GB9605690D0 (en) | 1996-03-19 | 1996-05-22 | Oxford Biosciences Ltd | Particle delivery |
US5718684A (en) * | 1996-05-24 | 1998-02-17 | Gupta; Mukesh | Multi-lobed balloon catheter |
CA2209366C (en) * | 1996-09-13 | 2004-11-02 | Interventional Technologies, Inc. | Incisor-dilator with tapered balloon |
US5797935A (en) * | 1996-09-26 | 1998-08-25 | Interventional Technologies Inc. | Balloon activated forced concentrators for incising stenotic segments |
US5713913A (en) * | 1996-11-12 | 1998-02-03 | Interventional Technologies Inc. | Device and method for transecting a coronary artery |
US5860957A (en) * | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
EP0888790A1 (en) | 1997-07-04 | 1999-01-07 | PowderJect Research Limited | Drug particle delivery device |
EP0888791A1 (en) | 1997-07-04 | 1999-01-07 | PowderJect Research Limited | Syringe and drug capsule therefor |
US5928193A (en) * | 1997-10-03 | 1999-07-27 | Boston Scientific Corporation | Balloon catheterization |
US6398798B2 (en) * | 1998-02-28 | 2002-06-04 | Lumend, Inc. | Catheter system for treating a vascular occlusion |
US6096054A (en) * | 1998-03-05 | 2000-08-01 | Scimed Life Systems, Inc. | Expandable atherectomy burr and method of ablating an occlusion from a patient's blood vessel |
US6223304B1 (en) * | 1998-06-18 | 2001-04-24 | Telefonaktiebolaget Lm Ericsson (Publ) | Synchronization of processors in a fault tolerant multi-processor system |
US6081577A (en) * | 1998-07-24 | 2000-06-27 | Wake Forest University | Method and system for creating task-dependent three-dimensional images |
US6036708A (en) * | 1998-08-13 | 2000-03-14 | Advanced Cardiovascular Systems, Inc. | Cutting stent with flexible tissue extractor |
US6003706A (en) * | 1998-09-17 | 1999-12-21 | Polyfoam Packers Corporation | Adjustable depth insulated container |
US5919200A (en) * | 1998-10-09 | 1999-07-06 | Hearten Medical, Inc. | Balloon catheter for abrading a patent foramen ovale and method of using the balloon catheter |
US6266533B1 (en) * | 1998-12-11 | 2001-07-24 | Ericsson Inc. | GPS assistance data for positioning of mobiles with built-in GPS |
US6328714B1 (en) | 1999-01-29 | 2001-12-11 | Powderject Research Limited | Particle delivery device |
US6556695B1 (en) * | 1999-02-05 | 2003-04-29 | Mayo Foundation For Medical Education And Research | Method for producing high resolution real-time images, of structure and function during medical procedures |
GB9905933D0 (en) * | 1999-03-15 | 1999-05-05 | Powderject Res Ltd | Neeedleless syringe |
ES2208322T3 (en) | 1999-04-16 | 2004-06-16 | Powderject Research Limited | SYRINGE WITHOUT NEEDLE. |
US6428517B1 (en) * | 1999-05-10 | 2002-08-06 | Milestone Scientific, Inc. | Hand-piece for injection device with a retractable and rotating needle |
GB9916800D0 (en) | 1999-07-16 | 1999-09-22 | Powderject Res Ltd | Needleless syringe |
FR2799031B1 (en) * | 1999-09-24 | 2002-01-04 | Ge Medical Syst Sa | METHOD FOR RECONSTRUCTING A SECTION, FOR EXAMPLE CROSS-SECTION, OF AN ELEMENT OF INTEREST CONTAINED IN AN OBJECT, IN PARTICULAR A VESSEL OF THE HUMAN HEART |
US6252924B1 (en) * | 1999-09-30 | 2001-06-26 | General Electric Company | Method and apparatus for motion-free cardiac CT imaging |
US6256368B1 (en) * | 1999-10-15 | 2001-07-03 | General Electric Company | Methods and apparatus for scout-based cardiac calcification scoring |
US6235038B1 (en) * | 1999-10-28 | 2001-05-22 | Medtronic Surgical Navigation Technologies | System for translation of electromagnetic and optical localization systems |
US6249693B1 (en) * | 1999-11-01 | 2001-06-19 | General Electric Company | Method and apparatus for cardiac analysis using four-dimensional connectivity and image dilation |
GB0018035D0 (en) | 2000-07-21 | 2000-09-13 | Powderject Res Ltd | Needleless syringe |
EP1305078B1 (en) * | 2000-07-24 | 2011-06-29 | Jeffrey Grayzel | Stiffened balloon catheter for dilatation and stenting |
US6416523B1 (en) * | 2000-10-03 | 2002-07-09 | Scimed Life Systems, Inc. | Method and apparatus for creating channels through vascular total occlusions |
GB0100756D0 (en) | 2001-01-11 | 2001-02-21 | Powderject Res Ltd | Needleless syringe |
US6428552B1 (en) * | 2001-01-22 | 2002-08-06 | Lumend, Inc. | Method and apparatus for crossing intravascular occlusions |
US20030019558A1 (en) * | 2001-07-26 | 2003-01-30 | Smith Edward R. | Particle cassette, method and kit therefor |
GB0118266D0 (en) * | 2001-07-26 | 2001-09-19 | Powderject Res Ltd | Silencing device and method for needleless syringe |
JP4153424B2 (en) * | 2001-08-06 | 2008-09-24 | エム.エル.アイ.エス.プロジェクツ リミテッド | Multi-compartment container assembly system |
US6562062B2 (en) * | 2001-08-10 | 2003-05-13 | Scimed Life Systems, Inc. | Balloon anchoring system |
US6632231B2 (en) * | 2001-08-23 | 2003-10-14 | Scimed Life Systems, Inc. | Segmented balloon catheter blade |
US6951566B2 (en) * | 2002-01-25 | 2005-10-04 | Scimed Life Systems, Inc. | Reciprocating cutting and dilating balloon |
US7985234B2 (en) * | 2002-02-27 | 2011-07-26 | Boston Scientific Scimed, Inc. | Medical device |
US7329267B2 (en) * | 2002-12-23 | 2008-02-12 | Boston Scientific Scimed, Inc. | Medical cutting devices and methods of use |
US7377383B2 (en) * | 2005-06-27 | 2008-05-27 | Henry John R | Multi-chamber container for mixing ingredients at time of use |
US7614496B2 (en) | 2005-08-29 | 2009-11-10 | Steven Dvorak | Aqueous solution of an analgesic and a dispenser therefor |
GB0611443D0 (en) * | 2006-06-09 | 2006-07-19 | Powderject Res Ltd | Improvements in, or relating to, particle cassettes |
-
2002
- 2002-07-25 US US10/484,751 patent/US8061006B2/en not_active Expired - Fee Related
-
2008
- 2008-02-20 US US12/071,324 patent/US20080300535A1/en not_active Abandoned
Patent Citations (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US533505A (en) * | 1895-02-05 | Barrel-support | ||
US1300654A (en) * | 1919-01-30 | 1919-04-15 | William H Rose | Dry-spraying machine. |
US1434460A (en) * | 1922-02-21 | 1922-11-07 | Tibbatts James | Metallic nursing bottle |
US1861047A (en) * | 1929-05-13 | 1932-05-31 | Parke Davis & Co | Sealed capsule |
US1774258A (en) * | 1929-07-08 | 1930-08-26 | Raymond A English | Duplex capsule or the like |
US2151418A (en) * | 1937-05-12 | 1939-03-21 | Scott & Bowne | Powder applicator |
US2147158A (en) * | 1937-09-28 | 1939-02-14 | Goldenthal Philip | Powder insufflator |
US2307986A (en) * | 1940-02-15 | 1943-01-12 | Bolte | Insufflator |
US2314527A (en) * | 1940-07-06 | 1943-03-23 | Atlantic Coast Fisheries Co | Method of making sealed capsules |
US2478715A (en) * | 1948-07-14 | 1949-08-09 | Vilbiss Co | Powder blower |
US2594093A (en) * | 1949-02-05 | 1952-04-22 | Armour & Co | Powder container |
US2470298A (en) * | 1949-02-07 | 1949-05-17 | Abbott Lab | Powdered medicine dispenser |
US3216562A (en) * | 1963-06-13 | 1965-11-09 | Driaire Inc | Easy-open capsule |
US3324902A (en) * | 1965-05-26 | 1967-06-13 | Bartelt Engineering Co Inc | Method of filling capsules |
US3508677A (en) * | 1968-08-20 | 1970-04-28 | Whittaker Corp | Vessel for storing high-pressure gases |
US3674028A (en) * | 1969-06-04 | 1972-07-04 | Ims Ltd | Multi-mix |
US3659600A (en) * | 1970-02-24 | 1972-05-02 | Estin Hans H | Magnetically operated capsule for administering drugs |
US3736933A (en) * | 1970-12-02 | 1973-06-05 | B Szabo | Burstable seamed hypodermic applicators |
US3664495A (en) * | 1970-12-21 | 1972-05-23 | Parke Davis & Co | Locking capsule |
US3735761A (en) * | 1971-02-11 | 1973-05-29 | Ampoules Inc | Hypodermic devices |
US3797491A (en) * | 1971-02-11 | 1974-03-19 | Ampoules Inc | Method of performing an intramuscular injection |
US3797490A (en) * | 1971-02-11 | 1974-03-19 | Ampoules Inc | Hypodermic ampoule with skin tensioning clip |
US3788315A (en) * | 1971-04-20 | 1974-01-29 | S Laurens | Disposable cutaneous transjector |
US3810469A (en) * | 1972-05-24 | 1974-05-14 | Ampoules Inc | Multiple compartment hypodermic devices |
US3782380A (en) * | 1973-01-04 | 1974-01-01 | Gaast H V D | Medicament injecting device |
US3967761A (en) * | 1974-04-08 | 1976-07-06 | Southwest Research Institute | System for injecting particulate material into the combustion chamber of a repetitive combustion coating apparatus |
US4031892A (en) * | 1974-07-18 | 1977-06-28 | Ampoules Corporation | Two-chamber mixing syringe |
US4081077A (en) * | 1977-01-13 | 1978-03-28 | Minnesota Mining And Manufacturing Company | Compartmented package |
US4360969A (en) * | 1978-09-22 | 1982-11-30 | Bicc Limited | Chain of electrical connector housings and a method of fitting a housing to an electrical contact |
US4226236A (en) * | 1979-05-07 | 1980-10-07 | Abbott Laboratories | Prefilled, vented two-compartment syringe |
US4474303A (en) * | 1981-08-28 | 1984-10-02 | Maccise Adiv Y | Portable modular food container |
US4416370A (en) * | 1982-08-25 | 1983-11-22 | Robert Beall | Compartmented container |
US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
US4893721A (en) * | 1982-10-29 | 1990-01-16 | Warner-Lambert Company | Tamper-proof capsules |
US4515586A (en) * | 1982-11-30 | 1985-05-07 | Abbott Laboratories | Powder syringe mixing system |
US4581875A (en) * | 1983-06-20 | 1986-04-15 | Cosden Technology, Inc. | Process for forming tamper-resistant tamper-indicative capsules |
US4517815A (en) * | 1983-10-07 | 1985-05-21 | Basso Peter J | Insulated modular cooler |
US4738817A (en) * | 1983-11-17 | 1988-04-19 | Warner-Lambert Company | Method for forming pharmaceutical capsules from hydrophilic polymers |
US5036006A (en) * | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US4945050A (en) * | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
US5100792A (en) * | 1984-11-13 | 1992-03-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues |
US4596556A (en) * | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US4774085A (en) * | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
US4811731A (en) * | 1985-07-30 | 1989-03-14 | Glaxo Group Limited | Devices for administering medicaments to patients |
US4858759A (en) * | 1985-12-21 | 1989-08-22 | Hilti Aktiengesellschaft | Container arrangement for cartridge dispensing two-component mass |
US5053389A (en) * | 1986-04-18 | 1991-10-01 | Per Balschmidt | Insulin preparation for non-parenteral administration |
USRE33801E (en) * | 1986-05-09 | 1992-01-21 | Dentsply Research & Development Corp. | Mixing and discharge capsule |
US4703863A (en) * | 1986-08-21 | 1987-11-03 | Kohusmariol Inc. | Baby feeding bottle assembly |
US5120657A (en) * | 1986-12-05 | 1992-06-09 | Agracetus, Inc. | Apparatus for genetic transformation |
US5394980A (en) * | 1987-06-30 | 1995-03-07 | Tsai; Min H. | Multicompartment mixing capsule |
US4939827A (en) * | 1987-10-20 | 1990-07-10 | Diado Metal Company Ltd. | Method of manufacturing a bearing device including a housing with a flange at one end thereof and a bearing bush press-fitted thereinto |
US4778068A (en) * | 1987-11-24 | 1988-10-18 | Kohusmariol Inc. | Baby-feeding bottle |
US5179022A (en) * | 1988-02-29 | 1993-01-12 | E. I. Du Pont De Nemours & Co. | Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner |
US4852757A (en) * | 1988-04-21 | 1989-08-01 | Milton Gold | Adapter for expanding the volume of a container |
US4966581A (en) * | 1988-04-22 | 1990-10-30 | Vitajet Industria E. Commercio Ltda | Non reusable disposable capsule containing an individual vaccine dose to be hypodermically injected with a pressure needleless injection apparatus |
US4991377A (en) * | 1988-09-19 | 1991-02-12 | Massimo Marchesini | Method for the mutual joining of the cap and the body of a capsule used to enclose medicines and apparatus which carries out this method |
US5141496A (en) * | 1988-11-03 | 1992-08-25 | Tino Dalto | Spring impelled syringe guide with skin penetration depth adjustment |
US4863017A (en) * | 1988-11-09 | 1989-09-05 | Vlock D G | Amalgam capsule |
US4910866A (en) * | 1989-02-21 | 1990-03-27 | Micron Technology, Inc. | Method of manufacturing a series of leadframe strip carriers having fixed external dimensions and varied internal dimensions using a common mold |
US5239991A (en) * | 1989-06-21 | 1993-08-31 | Fisons Plc | Disposable powder medicament inhalation device with peel-off cover |
US5062830A (en) * | 1990-04-04 | 1991-11-05 | Derata Corporation | Dry disposable nozzle assembly for medical jet injector |
US5204253A (en) * | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
US5149655A (en) * | 1990-06-21 | 1992-09-22 | Agracetus, Inc. | Apparatus for genetic transformation |
US5207217A (en) * | 1990-07-16 | 1993-05-04 | Promo Pack Sa | Multiple single-dose inhaler for medicaments in powder form |
US5042472A (en) * | 1990-10-15 | 1991-08-27 | Merck & Co., Inc. | Powder inhaler device |
US5188615A (en) * | 1990-11-19 | 1993-02-23 | Habley Medical Technology Corp. | Mixing vial |
US5046618A (en) * | 1990-11-19 | 1991-09-10 | R. P. Scherer Corporation | Child-resistant blister pack |
US5228573A (en) * | 1991-04-23 | 1993-07-20 | Richard Pavelle | Pharmaceutical capsule and method of making |
US5492112A (en) * | 1991-05-20 | 1996-02-20 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
US5102388A (en) * | 1991-07-15 | 1992-04-07 | Richmond John E | Sequential delivery syringe |
US5256142A (en) * | 1991-08-06 | 1993-10-26 | Sicim Spa | Injector administering subcutaneous injections without a needle and with a one-shot cap |
US5560490A (en) * | 1992-09-09 | 1996-10-01 | Fisons Plc | Pharmaceutical packaging with capsule sealing means |
US5658892A (en) * | 1993-01-15 | 1997-08-19 | The General Hospital Corporation | Compound delivery using high-pressure impulse transients |
US5630796A (en) * | 1993-04-08 | 1997-05-20 | Oxford Biosciences Limited | Method of delivering powder transdermally with needless injector |
US6168587B1 (en) * | 1993-04-08 | 2001-01-02 | Powderject Research Limited | Needleless syringe using supersonic gas flow for particle delivery |
US6881200B2 (en) * | 1993-04-08 | 2005-04-19 | Powderject Research Limited | Needleless syringe using super sonic gas flow for particle delivery |
US5349947A (en) * | 1993-07-15 | 1994-09-27 | Newhouse Michael T | Dry powder inhaler and process that explosively discharges a dose of powder and gas from a soft plastic pillow |
US5415162A (en) * | 1994-01-18 | 1995-05-16 | Glaxo Inc. | Multi-dose dry powder inhalation device |
US5865796A (en) * | 1994-01-21 | 1999-02-02 | Powderject Vaccines, Inc | Gas driven gene delivery instrument |
US5899880A (en) * | 1994-04-08 | 1999-05-04 | Powderject Research Limited | Needleless syringe using supersonic gas flow for particle delivery |
US5422129A (en) * | 1994-04-11 | 1995-06-06 | Draddy; John G. | Dispensing display container and particulate coffee therein |
US6592545B1 (en) * | 1994-12-23 | 2003-07-15 | Powderject Research Limited | Particle delivery |
US6010478A (en) * | 1995-02-14 | 2000-01-04 | Powderject Research Limited | Trans-mucosal particle delivery |
US6013050A (en) * | 1995-10-20 | 2000-01-11 | Powderject Research Limited | Particle delivery |
US5947928A (en) * | 1997-06-19 | 1999-09-07 | Mile Creek Capital, Llc | Drug delivery system |
US6923800B2 (en) * | 1997-07-25 | 2005-08-02 | Alza Corporation | Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems |
US6953039B2 (en) * | 1998-05-05 | 2005-10-11 | Trudell Medical International | Medicament dispensing device |
US7014651B2 (en) * | 1999-03-11 | 2006-03-21 | Alsius Corporation | Method and system for treating cardiac arrest using hypothermia |
US7691407B2 (en) * | 1999-07-30 | 2010-04-06 | Smithkline Beecham Plc | Multi-component pharmaceutical dosage form |
US7044134B2 (en) * | 1999-11-08 | 2006-05-16 | Ev3 Sunnyvale, Inc | Method of implanting a device in the left atrial appendage |
US6595352B2 (en) * | 2000-02-21 | 2003-07-22 | Coltene Ag | Container for receiving a filling product and a method for its manufacture |
US20010015326A1 (en) * | 2000-02-21 | 2001-08-23 | Coltene Ag | Container for receiving a filling product and a method for its manufacture |
US6276547B1 (en) * | 2000-06-09 | 2001-08-21 | Thomas M. Petryna | Food containers with detachable and discardable sections |
US7562771B2 (en) * | 2000-10-25 | 2009-07-21 | Lameplast S.P.A. | Bottle for two-component extemporaneous products |
US6929005B2 (en) * | 2001-01-12 | 2005-08-16 | Becton, Dickinson And Company | Medicament respiratory delivery device, cartridge and method of making same |
US6949154B2 (en) * | 2001-07-28 | 2005-09-27 | Boehringer Ingelheim Pharma Kg | Method and apparatus for sealing medicinal capsules |
US7121402B2 (en) * | 2003-04-09 | 2006-10-17 | Reactive Nano Technologies, Inc | Container hermetically sealed with crushable material and reactive multilayer material |
US20070185450A1 (en) * | 2006-02-01 | 2007-08-09 | Marco De Polo | Self-sealing connection for housing shells of an administering device |
US20090110723A1 (en) * | 2007-10-15 | 2009-04-30 | Mcallister Stephen Mark | Linkers for multipart dosage forms for release of one or more pharmaceutical compositions, and the resulting dosage forms |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE43824E1 (en) | 2001-01-11 | 2012-11-20 | Powder Pharmaceuticals Inc. | Needleless syringe |
US20090088508A1 (en) * | 2003-07-25 | 2009-04-02 | Degussa Ag | Powdery composition of a polymer and a flameproofing agent containing ammonium polyphosphate, method for the production thereof, and moulded body produced from said powder |
US20100324190A1 (en) * | 2003-07-25 | 2010-12-23 | Degussa Ag | Powdery composition of a polymer and a flameproofing agent containing ammonium polyphosphate, method for the production thereof, and moulded body produced from said powder |
US20100298767A1 (en) * | 2006-06-09 | 2010-11-25 | Bates Nigel Robert | Particle Cassettes |
US8298173B2 (en) * | 2006-06-09 | 2012-10-30 | Bates Nigel Robert | Particle cassettes |
US8540665B2 (en) | 2007-05-04 | 2013-09-24 | Powder Pharmaceuticals Inc. | Particle cassettes and processes therefor |
US20130338579A1 (en) * | 2007-05-04 | 2013-12-19 | Nigel R. Bates | Particle cassettes and processes therefor |
US9044546B2 (en) * | 2007-05-04 | 2015-06-02 | Powder Pharmaceuticals Incorporated | Particle cassettes and processes therefor |
US9358338B2 (en) | 2007-05-04 | 2016-06-07 | Powder Pharmaceuticals Incorporated | Particle cassettes and processes therefor |
US8388569B2 (en) | 2011-04-19 | 2013-03-05 | Xerox Corporation | Delivery devices and methods with collimated gas stream and particle source |
US8430839B2 (en) | 2011-04-19 | 2013-04-30 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and drug reservoir |
US8486002B2 (en) | 2011-04-19 | 2013-07-16 | Palo Alto Research Center Incorporated | Drug delivery devices and methods with collimated gas stream and release-activatable tape |
Also Published As
Publication number | Publication date |
---|---|
US20040255447A1 (en) | 2004-12-23 |
US8061006B2 (en) | 2011-11-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20080300535A1 (en) | Particle cassette, method and kit therefor | |
JP7150904B2 (en) | Connection and vessel system | |
US20160262982A1 (en) | Medical Connecting Device | |
WO2012002314A1 (en) | Connector and connector assembly | |
CN107920954B (en) | Connection and container system | |
JP2005512639A (en) | INJECTION DEVICE AND METHOD | |
KR19980024390A (en) | Transport assembly for medical container with anti-fry valve | |
TW200827248A (en) | Closure system for containers | |
CN106999348B (en) | Mixing and/or transfer device | |
US20190360607A1 (en) | Stabilized Valve with Guide | |
JP2003305107A (en) | Medicine discharge member and medical double-chamber container | |
WO2003095325A1 (en) | Contamination preventive cap | |
US20030019558A1 (en) | Particle cassette, method and kit therefor | |
US20220241050A1 (en) | Cartridge for dispensing a material | |
JP7426329B2 (en) | Connection and container system | |
EP1409045B1 (en) | Particle cassette, method and kit therefor | |
JP7224509B2 (en) | Integrated cap and seal system | |
AU2002355665A1 (en) | Particle cassette, method and kit therefor | |
WO2010004926A1 (en) | Medication-containing container | |
JP4594178B2 (en) | Multi-chamber container | |
JP5594687B2 (en) | Drug discharge tool and multi-chamber container using drug discharge tool | |
JP3056735B1 (en) | Syringe | |
JP2007307414A (en) | Discharge method of medical agent | |
JP5963741B2 (en) | Drug storage container | |
CZ294054B6 (en) | Stopper |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |