US20080161265A1 - Use of lactulose in the treatment of autism - Google Patents

Use of lactulose in the treatment of autism Download PDF

Info

Publication number
US20080161265A1
US20080161265A1 US12/049,613 US4961308A US2008161265A1 US 20080161265 A1 US20080161265 A1 US 20080161265A1 US 4961308 A US4961308 A US 4961308A US 2008161265 A1 US2008161265 A1 US 2008161265A1
Authority
US
United States
Prior art keywords
lactulose
composition
effective amount
ammonia
autism
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/049,613
Inventor
Joan M. Fallon
Richard Feltenstein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curemark LLC
Original Assignee
Fallon Joan M
Richard Feltenstein
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fallon Joan M, Richard Feltenstein filed Critical Fallon Joan M
Priority to US12/049,613 priority Critical patent/US20080161265A1/en
Publication of US20080161265A1 publication Critical patent/US20080161265A1/en
Assigned to CUREMARK, LLC reassignment CUREMARK, LLC ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: FALLON, JOAN M.
Priority to US13/204,881 priority patent/US8673877B2/en
Priority to US14/087,930 priority patent/US9345721B2/en
Priority to US15/089,842 priority patent/US10350229B2/en
Priority to US16/422,079 priority patent/US11033563B2/en
Priority to US17/306,614 priority patent/US20210252031A1/en
Abandoned legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Definitions

  • the invention relates to a treatment for autism, and more particularly, to the use of lactulose in the treatment of autism.
  • Autism is the most prevalent of a subset of disorders organized under the umbrella of pervasive developmental disorder (PDD).
  • PDD pervasive developmental disorder
  • Autism is a serious developmental disorder characterized by profound deficits in language, communication, and socialization, resistance to learning, and displays of stereotypical behavior including perseveration.
  • a spectrum disorder ASD
  • Autism is a life-long developmental disorder affecting as many as 1 in 500 children. Recent studies have indicated that the prevalence is closer to 1 in 166 live births. The causes of this profound disorder are largely unknown.
  • Recent research has uncovered pathology in the gastrointestinal tract of autistic children. The pathology is reported to extend from the esophagus to the colon.
  • Lactulose is presently used in the treatment of constipation and hepatic encephalopathy.
  • the efficacy of lactulose in these conditions is based on its fermentation in the colon by certain bacteria and the increase of the biomass of these bacteria in the colon.
  • the products of fermentation are mainly organic acids, such as lactic acid and small-chain fatty acids, which, by exerting a local osmotic effect in the colon, result in increased fecal bulk and stimulation of peristalsis.
  • the higher doses used for hepatic encephalopathy lower the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and improves mental function.
  • Increased or high levels of ammonia in the blood stream can produce toxicity to the cells of the body especially to the cells of the nervous system. This neurotoxicity can alter brain function and cause other neurological diseases, including autism. Thus, decreasing the levels of ammonia in the blood would decrease the levels of ammonia in the brain thereby reducing the neurotoxic effects.
  • Augmentin® amoxicillin+clavulanate potassium
  • Augmentin® amoxicillin+clavulanate potassium
  • lactulose has been used for years as a treatment for constipation and hepatic encephalopathy. However, lactulose has not previously been used as a treatment for autism or autism prevention. Presently, there exists no other pharmaceutical or biological treatment for autism. Since there is no pharmaceutical or biological treatment for autism, other than psychotropic medications for symptoms, only behavioral and educational solutions have been offered. Behavioral treatments, such as applied behavioral analysis and TEACCH (Treatment and Education of Autistic and related Communication Handicapped Children) and others, have some value in the treatment of these children but do not address the physiological, specifically gastrointestinal, problems encountered by them.
  • TEACCH Treatment and Education of Autistic and related Communication Handicapped Children
  • It is a goal of the present invention provide a treatment for autism that addresses the physiological symptoms of the disorder.
  • lactulose is used to bind ammonia in the gastrointestinal tract, the bloodstream, and the nervous system.
  • FIG. 1 is a block diagram illustrating the mechanism of the function of lactulose in the colon.
  • Lactulose is a semisynthetic disaccharide comprised of the sugars D-galactose and D-fructose. It is not found naturally. The sugars are joined by a beta glycosidic linkage making it resistant to hydrolysis by human digestive enzymes. There is no disaccharidase in the microvillus membrane of small intestine enterocytes that can hydrolyze lactulose; nor is the disaccharide absorbed from the small intestine. Lactulose is, however, fermented by a limited number of colonic bacteria. This can lead to changes in the colonic ecosystem in favor of some bacteria, such as lactobacilli and bifidobacteria, which may confer some health benefits.
  • Lactulose is a solid substance that is very soluble in water and has a sweet taste. It is sweeter than lactose but not as sweet as fructose. Lactulose is also known as 4-O-beta-D-galactopyranosyl-D-fructofuranose. Its molecular formula is C 12 H 22 O 11 , and its molecular weight is 342.30 daltons. The structural formula is:
  • Lactulose has an inhibiting action on ammonia production in the ileum and reduces the ammonia level in portal circulation.
  • lactulose molecules pass through the stomach and ileum unsplit.
  • the lactulose is fermented by certain bacteria, which supplies carbohydrates and energy. This results in an increase of the biomass of these bacteria in the colon.
  • the products of fermentation are mainly organic acids, such as lactic acid and small-chain fatty acids, which, by exerting a local osmotic effect in the colon, result in increased fecal bulk and stimulation of peristalsis.
  • the fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and improves mental function.
  • Augmentin® amoxicillin-clavulanate
  • urea or another available ammonia source to a fermentation broth. This additional ammonia represses the number of enzymes involved in the metabolism of nitrogen, including urease, which catalyzes the conversion of urea to ammonia and carbon dioxide.
  • urease which catalyzes the conversion of urea to ammonia and carbon dioxide.
  • Urea and/or nitrogen poisoning has a two-fold effect in humans: 1) a neurotoxic effect on brain tissue and 2) a corrosive effect on the digestive tract, specifically damage to the secretory cells of the small intestine, due to the highly alkaline nature of NH 3 .
  • Signs of urea poisoning include colic, bloating, diarrhea, muscle tremors, difficulty with coordination, weakness, and poor appetite.
  • 206 children with autism not related to a known genetic condition, birth trauma, or known neurological disease were examined and a detailed case history was obtained.
  • the 206 children tested had a mean number of 9.96 instances of otitis media with a standard error of the mean of ⁇ 1.83. This represented a sum total for the 206 children under age three of 2052 bouts of otitis media.
  • These children received a mean number of 12.04 courses of antibiotics with a standard error of the mean of ⁇ 0.13.
  • the total number of courses given to all of the children in the study was 2,480. Of those courses, 893 were Augmentin®, with 362 of those courses of Augmentin® being administered to children under age one.
  • the treatment has a formulation of 0.4 g/kg lactulose and 0.1 g/kg mannitol. In another embodiment, the treatment has a formulation of 0.3 g/kg lactulose. In either embodiment, the treatment is administered two to five times per day.
  • the lactulose may be administered in the form of a powder, liquid solution, or syrup.

Abstract

A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and reduces neurotoxicity.

Description

    RELATED APPLICATIONS
  • This application claims the benefit of U.S. Provisional Application No. 60/712,551, filed Aug. 30, 2005. This application is herein incorporated in its entirety by reference.
    • FIELD OF THE INVENTION
  • The invention relates to a treatment for autism, and more particularly, to the use of lactulose in the treatment of autism.
    • BACKGROUND OF THE INVENTION
  • Autism is the most prevalent of a subset of disorders organized under the umbrella of pervasive developmental disorder (PDD). Autism is a serious developmental disorder characterized by profound deficits in language, communication, and socialization, resistance to learning, and displays of stereotypical behavior including perseveration. Known now as a spectrum disorder (ASD), it includes a myriad of behavioral, emotional, and physiological symptoms. Autism is a life-long developmental disorder affecting as many as 1 in 500 children. Recent studies have indicated that the prevalence is closer to 1 in 166 live births. The causes of this profound disorder are largely unknown. Recent research has uncovered pathology in the gastrointestinal tract of autistic children. The pathology is reported to extend from the esophagus to the colon.
  • Lactulose is presently used in the treatment of constipation and hepatic encephalopathy. The efficacy of lactulose in these conditions is based on its fermentation in the colon by certain bacteria and the increase of the biomass of these bacteria in the colon. The products of fermentation are mainly organic acids, such as lactic acid and small-chain fatty acids, which, by exerting a local osmotic effect in the colon, result in increased fecal bulk and stimulation of peristalsis. The higher doses used for hepatic encephalopathy lower the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and improves mental function.
  • Increased or high levels of ammonia in the blood stream can produce toxicity to the cells of the body especially to the cells of the nervous system. This neurotoxicity can alter brain function and cause other neurological diseases, including autism. Thus, decreasing the levels of ammonia in the blood would decrease the levels of ammonia in the brain thereby reducing the neurotoxic effects.
  • Certain drugs such as Augmentin® (amoxicillin+clavulanate potassium) have been known to leave an ammonia residue in the gastrointestinal tract. The increased levels of ear infections in children with autism and the use of Augmentin® to treat these and other infections makes the child vulnerable to the potential buildup of ammonia in the digestive system as well as the blood, thus leading to a potential neurotoxic state. By giving lactulose immediately following the administration of Augmentin® or other ammonia producing substances, the potential for a neurotoxic disease is reduced.
  • It can be appreciated that lactulose has been used for years as a treatment for constipation and hepatic encephalopathy. However, lactulose has not previously been used as a treatment for autism or autism prevention. Presently, there exists no other pharmaceutical or biological treatment for autism. Since there is no pharmaceutical or biological treatment for autism, other than psychotropic medications for symptoms, only behavioral and educational solutions have been offered. Behavioral treatments, such as applied behavioral analysis and TEACCH (Treatment and Education of Autistic and related Communication Handicapped Children) and others, have some value in the treatment of these children but do not address the physiological, specifically gastrointestinal, problems encountered by them.
  • What is needed, therefore, is a treatment for autism that works by preventing the build up of ammonia in the gastrointestinal tract, the bloodstream, and the nervous system.
    • SUMMARY OF THE INVENTION
  • It is a goal of the present invention provide a treatment for autism that addresses the physiological symptoms of the disorder.
  • It is another goal of the present invention to provide a treatment for autism that works by preventing the build up of ammonia in the gastrointestinal tract, the bloodstream, and the nervous system.
  • It is a further goal of the present invention to provide a treatment for autism that reverses the effects of ammonia poisoning on the gastrointestinal tract, the bloodstream, and the nervous system caused by certain antibiotics.
  • In one embodiment, lactulose is used to bind ammonia in the gastrointestinal tract, the bloodstream, and the nervous system.
  • The features and advantages described herein are not all-inclusive and, in particular, many additional features and advantages will be apparent to one of ordinary skill in the art in view of the drawings, specification, and claims. Moreover, it should be noted that the language used in the specification has been principally selected for readability and instructional purposes, and not to limit the scope of the inventive subject matter.
    • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a block diagram illustrating the mechanism of the function of lactulose in the colon.
    •  DETAILED DESCRIPTION
  • Lactulose is a semisynthetic disaccharide comprised of the sugars D-galactose and D-fructose. It is not found naturally. The sugars are joined by a beta glycosidic linkage making it resistant to hydrolysis by human digestive enzymes. There is no disaccharidase in the microvillus membrane of small intestine enterocytes that can hydrolyze lactulose; nor is the disaccharide absorbed from the small intestine. Lactulose is, however, fermented by a limited number of colonic bacteria. This can lead to changes in the colonic ecosystem in favor of some bacteria, such as lactobacilli and bifidobacteria, which may confer some health benefits.
  • Lactulose is a solid substance that is very soluble in water and has a sweet taste. It is sweeter than lactose but not as sweet as fructose. Lactulose is also known as 4-O-beta-D-galactopyranosyl-D-fructofuranose. Its molecular formula is C12H22O11, and its molecular weight is 342.30 daltons. The structural formula is:
  • Figure US20080161265A1-20080703-C00001
  • Lactulose has an inhibiting action on ammonia production in the ileum and reduces the ammonia level in portal circulation. Referring to FIG. 1, lactulose molecules pass through the stomach and ileum unsplit. Once in the colon, the lactulose is fermented by certain bacteria, which supplies carbohydrates and energy. This results in an increase of the biomass of these bacteria in the colon. The products of fermentation are mainly organic acids, such as lactic acid and small-chain fatty acids, which, by exerting a local osmotic effect in the colon, result in increased fecal bulk and stimulation of peristalsis. The fermentation process lowers the colonic pH, and ammonia, in the form of ammonium ions, is used by the bacteria for amino acid and protein synthesis. This lowers the serum ammonia levels and improves mental function.
  • It has been postulated that there is a relationship between the use of the antibiotic Augmentin® and autism. Many autistic children suffer from chronic otitis media (ear infections) prior to age three. Otitis media is generally by two strains of bacteria, Streptococcus pneumoniae and Hemophilus influenzae. Augmentin® (amoxicillin-clavulanate) is a frequently prescribed antibiotic for this condition because it is effective against both of these strains. However, the process of manufacturing Augmentin® involves the addition of urea or another available ammonia source to a fermentation broth. This additional ammonia represses the number of enzymes involved in the metabolism of nitrogen, including urease, which catalyzes the conversion of urea to ammonia and carbon dioxide. Thus, there is the possibility of urea and/or nitrogen poisoning.
  • Urea and/or nitrogen poisoning has a two-fold effect in humans: 1) a neurotoxic effect on brain tissue and 2) a corrosive effect on the digestive tract, specifically damage to the secretory cells of the small intestine, due to the highly alkaline nature of NH3. Signs of urea poisoning include colic, bloating, diarrhea, muscle tremors, difficulty with coordination, weakness, and poor appetite.
  • In a study conducted by the inventor, 206 children with autism not related to a known genetic condition, birth trauma, or known neurological disease were examined and a detailed case history was obtained. The 206 children tested had a mean number of 9.96 instances of otitis media with a standard error of the mean of ±1.83. This represented a sum total for the 206 children under age three of 2052 bouts of otitis media. These children received a mean number of 12.04 courses of antibiotics with a standard error of the mean of ±0.13. The total number of courses given to all of the children in the study was 2,480. Of those courses, 893 were Augmentin®, with 362 of those courses of Augmentin® being administered to children under age one.
  • The increased levels of ear infections in children with autism combined with the use of Augmentin® to treat these infections has the potential to make these children vulnerable to the buildup of ammonia in the gastrointestinal tract, the bloodstream, and the nervous system, leading to a neurotoxic state. By administering lactulose subsequent to a course of treatment with Augmentin® or other antibiotics that leave an ammonia residue in the gastrointestinal tract, the potential for a neurological disease, such as autism, is reduced.
  • In one embodiment of the present invention, the treatment has a formulation of 0.4 g/kg lactulose and 0.1 g/kg mannitol. In another embodiment, the treatment has a formulation of 0.3 g/kg lactulose. In either embodiment, the treatment is administered two to five times per day. The lactulose may be administered in the form of a powder, liquid solution, or syrup.
  • The foregoing description of the embodiments of the invention has been presented for the purposes of illustration and description. It is not intended to be exhaustive or to limit the invention to the precise form disclosed. Many modifications and variations are possible in light of this disclosure. It is intended that the scope of the invention be limited not by this detailed description, but rather by the claims appended hereto.

Claims (11)

1-10. (canceled)
11. A composition for treating autism and the symptoms thereof in an individual comprising an effective amount of lactulose.
12. The composition of claim 11, wherein one of the symptoms is selected from a group consisting of a gastrointestinal disorder, a neurological disorder, and a combination thereof.
13. The composition of claim 11, wherein the effective amount of lactulose comprises about 0.4 g/kg lactulose and 0.1 g/kg mannitol per dose.
14. The composition of claim 11, wherein the effective amount of lactulose comprises about 0.3 g/kg lactulose per dose.
15. The composition of claim 11, wherein the effective amount of lactulose is administered approximately two to five times per day.
16. The composition of claim 11, wherein the effective amount of lactulose is manufactured in a form selected from the group consisting of a powder, liquid solution, syrup, and a combination thereof.
17. The composition of claim 11, wherein the effective amount of lactulose includes an amount of lactulose sufficient to decrease ammonia levels in the blood of the individual.
18. The composition of claim 11, wherein the effective amount of lactulose includes an amount of lactulose sufficient to decrease ammonia levels in the gastrointestinal tract of the individual.
19. The composition of claim 11, wherein the effective amount of lactulose includes an amount of lactulose sufficient to decrease ammonia levels in the nervous system of the individual.
20. The composition of claim 11, wherein the effective amount of lactulose includes an amount of lactulose sufficient to reverse ammonia poisoning caused by the administration of antibiotics that leave a residue in the gastrointestinal tract of the individual.
US12/049,613 2005-08-30 2008-03-17 Use of lactulose in the treatment of autism Abandoned US20080161265A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/049,613 US20080161265A1 (en) 2005-08-30 2008-03-17 Use of lactulose in the treatment of autism
US13/204,881 US8673877B2 (en) 2005-08-30 2011-08-08 Use of lactulose in the treatment of autism
US14/087,930 US9345721B2 (en) 2005-08-30 2013-11-22 Use of lactulose in the treatment of autism
US15/089,842 US10350229B2 (en) 2005-08-30 2016-04-04 Use of lactulose in the treatment of autism
US16/422,079 US11033563B2 (en) 2005-08-30 2019-05-24 Use of lactulose in the treatment of autism
US17/306,614 US20210252031A1 (en) 2005-08-30 2021-05-03 Use of lactulose in the treatment of autism

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71255105P 2005-08-30 2005-08-30
US11/468,379 US20080058282A1 (en) 2005-08-30 2006-08-30 Use of lactulose in the treatment of autism
US12/049,613 US20080161265A1 (en) 2005-08-30 2008-03-17 Use of lactulose in the treatment of autism

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US11/468,379 Division US20080058282A1 (en) 2005-08-30 2006-08-30 Use of lactulose in the treatment of autism

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/204,881 Division US8673877B2 (en) 2005-08-30 2011-08-08 Use of lactulose in the treatment of autism

Publications (1)

Publication Number Publication Date
US20080161265A1 true US20080161265A1 (en) 2008-07-03

Family

ID=39152552

Family Applications (7)

Application Number Title Priority Date Filing Date
US11/468,379 Abandoned US20080058282A1 (en) 2005-08-30 2006-08-30 Use of lactulose in the treatment of autism
US12/049,613 Abandoned US20080161265A1 (en) 2005-08-30 2008-03-17 Use of lactulose in the treatment of autism
US13/204,881 Active US8673877B2 (en) 2005-08-30 2011-08-08 Use of lactulose in the treatment of autism
US14/087,930 Active US9345721B2 (en) 2005-08-30 2013-11-22 Use of lactulose in the treatment of autism
US15/089,842 Active US10350229B2 (en) 2005-08-30 2016-04-04 Use of lactulose in the treatment of autism
US16/422,079 Active US11033563B2 (en) 2005-08-30 2019-05-24 Use of lactulose in the treatment of autism
US17/306,614 Abandoned US20210252031A1 (en) 2005-08-30 2021-05-03 Use of lactulose in the treatment of autism

Family Applications Before (1)

Application Number Title Priority Date Filing Date
US11/468,379 Abandoned US20080058282A1 (en) 2005-08-30 2006-08-30 Use of lactulose in the treatment of autism

Family Applications After (5)

Application Number Title Priority Date Filing Date
US13/204,881 Active US8673877B2 (en) 2005-08-30 2011-08-08 Use of lactulose in the treatment of autism
US14/087,930 Active US9345721B2 (en) 2005-08-30 2013-11-22 Use of lactulose in the treatment of autism
US15/089,842 Active US10350229B2 (en) 2005-08-30 2016-04-04 Use of lactulose in the treatment of autism
US16/422,079 Active US11033563B2 (en) 2005-08-30 2019-05-24 Use of lactulose in the treatment of autism
US17/306,614 Abandoned US20210252031A1 (en) 2005-08-30 2021-05-03 Use of lactulose in the treatment of autism

Country Status (1)

Country Link
US (7) US20080058282A1 (en)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020081628A1 (en) * 2000-11-16 2002-06-27 Fallon Joan M. Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20040071683A1 (en) * 1999-12-17 2004-04-15 Fallon Joan M. Methods for treating pervasive development disorders
US20070053895A1 (en) * 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
US20080166334A1 (en) * 2004-09-28 2008-07-10 Fallon Joan M Combination enzyme for cystic fibrosis
US20090232789A1 (en) * 2008-03-13 2009-09-17 Fallon Joan M Novel pharmaceutical preparation for preeclampsia, eclampsia, and toxemia, and their related symptoms and related disorders of pregnancy
US20090263372A1 (en) * 2008-04-18 2009-10-22 Fallon Joan M Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US20100169409A1 (en) * 2008-08-04 2010-07-01 Fallon Joan M Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of parkinsons disease, movement and neurological disorders, and chronic pain
US8673877B2 (en) 2005-08-30 2014-03-18 Curemark, Llc Use of lactulose in the treatment of autism
US8980252B2 (en) 2011-04-21 2015-03-17 Curemark Llc Methods of treatment of schizophrenia
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
US9061033B2 (en) 2008-10-03 2015-06-23 Curemark Llc Methods and compositions for the treatment of symptoms of prion diseases
US9084784B2 (en) 2009-01-06 2015-07-21 Curelon Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
US9107419B2 (en) 2009-01-06 2015-08-18 Curelon Llc Compositions and methods for treatment or prevention of Staphylococcus aureus infections and for the eradication or reduction of Staphylococcus aureus on surfaces
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US9385259B2 (en) 2011-12-06 2016-07-05 Solarworld Innovations Gmbh Method for manufacturing a metallization structure comprising aluminum and silicon
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
US11016104B2 (en) 2008-07-01 2021-05-25 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070116695A1 (en) * 2005-09-21 2007-05-24 Fallon Joan M Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
US10039777B2 (en) 2012-03-20 2018-08-07 Neuro-Lm Sas Methods and pharmaceutical compositions of the treatment of autistic syndrome disorders
US10218709B2 (en) * 2016-03-11 2019-02-26 Microsoft Technology Licensing, Llc Share permissions and organization of content in an application with multiple levels of organizational hierarchy
WO2018215961A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising oligosaccharides and its use in medical treatment.
CN108977468B (en) * 2018-09-06 2021-06-29 河北省科学院生物研究所 Method for improving efficiency and stability of anaerobic fermentation of antibiotic bacterium residues

Citations (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002883A (en) * 1959-07-29 1961-10-03 Dow Chemical Co Disinfectant compositions
US3223594A (en) * 1960-10-25 1965-12-14 Philips Corp Method of producing pancreatin
US3357894A (en) * 1963-10-18 1967-12-12 Ct Nat De La Recherche Proteolytic enzymes of pig pancreas
US3515642A (en) * 1965-12-06 1970-06-02 Takeda Chemical Industries Ltd Method for preparing a stabilized enzyme composition
US3574819A (en) * 1966-12-08 1971-04-13 Ciba Geigy Corp Pharmaceutical compositions for treating digestive disorders containing 4,7- phenanthrolin - 5,6 - quinone together with pancreatin,bromelin,dehydrocholic acid and 7 - iodo - 5 - chloro-8-hydroxyquinoline
US3940478A (en) * 1974-04-29 1976-02-24 Sutures, Inc. Proteolytic enzymes as adjuncts to antibiotic prophylaxis of contaminated wounds
US4079125A (en) * 1975-06-10 1978-03-14 Johnson & Johnson Preparation of enteric coated digestive enzyme compositions
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US5190775A (en) * 1991-05-29 1993-03-02 Balchem Corporation Encapsulated bioactive substances
US5250418A (en) * 1981-10-06 1993-10-05 Boehringer Mannheim Gmbh Process and reagent for determining the activity of chymotrypsin and trypsin in feces
US5324514A (en) * 1992-06-22 1994-06-28 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5436319A (en) * 1985-12-03 1995-07-25 T Cell Sciences, Inc. Cell free T cell antigen receptor beta chain and its clinical utilities
US5437319A (en) * 1992-08-28 1995-08-01 Black & Decker Inc. Pivoting power tool with table
US5527678A (en) * 1994-10-21 1996-06-18 Vanderbilt University CagB and CagC genes of helicobacter pylori and related compositions
US5607863A (en) * 1991-05-29 1997-03-04 Smithkline Diagnostics, Inc. Barrier-controlled assay device
US5648335A (en) * 1992-06-12 1997-07-15 Cephalon, Inc. Prevention and treatment of peripheral neuropathy
US5674532A (en) * 1989-11-24 1997-10-07 Biochemie Gesellschaft M.B.H. Pancreatin preparations
US5686311A (en) * 1995-06-23 1997-11-11 The Children's Mercy Hospital Diagnosis of autism and treatment therefor
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
US5952178A (en) * 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US5958875A (en) * 1996-03-29 1999-09-28 The Regents Of The University Of California Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity
US5985891A (en) * 1994-12-29 1999-11-16 Rowe; James Baber Prevention of adverse behavior, diarrhea, skin disorders and infections of the hind gut associated with acidic conditions in humans and animals by the application of antibiotics
US6011001A (en) * 1990-08-03 2000-01-04 Vertex Pharmaceuticals, Inc. Method of protein therapy by orally administering crosslinked protein crystals
US6020314A (en) * 1998-08-11 2000-02-01 Milkhaus Laboratory, Inc. Methods for treatment of neurological disorders
US6020310A (en) * 1997-05-19 2000-02-01 Repligen Corporation Method for assisting in differential diagnosis and treatment of autistic syndromes
US6153236A (en) * 1999-06-03 2000-11-28 Balchem Corporation Low melt encapsulation with high laurate canola oil
US6187309B1 (en) * 1999-09-14 2001-02-13 Milkaus Laboratory, Inc. Method for treatment of symptoms of central nervous system disorders
US6197746B1 (en) * 1998-05-19 2001-03-06 Repligen Corporation Method of using secretin for treating autism
US6210950B1 (en) * 1999-05-25 2001-04-03 University Of Medicine And Dentistry Of New Jersey Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors
US6251478B1 (en) * 1999-12-22 2001-06-26 Balchem Corporation Sensitive substance encapsulation
US6261613B1 (en) * 2000-02-15 2001-07-17 General Mills, Inc. Refrigerated and shelf-stable bakery dough products
US6280726B1 (en) * 1995-07-21 2001-08-28 New York University Type II phospholipase A2 and its use in killing Gram-positive bacteria
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US20020037284A1 (en) * 2000-08-14 2002-03-28 Fallon Joan M. Method for diagnosing and treating dysautonomia and other dysautonomic conditions
US6399101B1 (en) * 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
US6482839B1 (en) * 1997-06-02 2002-11-19 Cellegy Pharmaceuticals, Inc. Pyridine-thiols for treatment of a follicular dermatosis
US6534259B1 (en) * 1997-06-05 2003-03-18 Andrew Wakefield Regressive behavioral disorder diagnosis
US6534063B1 (en) * 1999-12-17 2003-03-18 Joan M. Fallon Methods for treating pervasive development disorders
US20030097122A1 (en) * 2001-04-10 2003-05-22 Ganz Robert A. Apparatus and method for treating atherosclerotic vascular disease through light sterilization
US20040057962A1 (en) * 2001-01-06 2004-03-25 Benedikt Timmerman Immunogenic complex
US20040076590A1 (en) * 2002-07-08 2004-04-22 Wilkins Joe S. Antibacterial toothpaste and mouthwash formulations
US6727073B1 (en) * 1999-11-19 2004-04-27 Binax, Inc. Method for detecting enteric disease
US20040101562A1 (en) * 2000-11-15 2004-05-27 Mario Maio Microspheres of pancreatic enzymes with high stability and production method thereof
US20040121002A1 (en) * 2002-12-23 2004-06-24 Lee Phillip K. Controlled release encapsulated bioactive substances
US6797291B2 (en) * 2002-01-09 2004-09-28 Balchem Corporation Stable hygroscopic compositions and methods for stabilizing hygroscopic ingredients
US20040209790A1 (en) * 2000-04-07 2004-10-21 Alex Sava Process and composition for cleaning medical instruments
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US20050187130A1 (en) * 2004-02-23 2005-08-25 Brooker Alan T. Granular laundry detergent composition comprising an anionic detersive surfactant, and low levels of, or no, zeolite builders and phosphate builders
US20060105379A1 (en) * 2001-04-26 2006-05-18 Shujian Wu Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29
US20060183180A1 (en) * 1999-12-17 2006-08-17 Fallon Joan M Methods for treating pervasive development disorders
US7101573B2 (en) * 2001-09-28 2006-09-05 Mcneil-Pcc, Inc. Simethicone solid oral dosage form
US7129053B1 (en) * 1999-10-12 2006-10-31 Dakocytomation Denmark A/S Immuno-chromatographic rapid assay in order to detect acid-resistant microorganisms in the stool
US20060259995A1 (en) * 2002-10-10 2006-11-16 Diversa Corporation Proteases, nucleic acids encoding them and methods for making and using them
US20070053895A1 (en) * 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
US20080166334A1 (en) * 2004-09-28 2008-07-10 Fallon Joan M Combination enzyme for cystic fibrosis
US20080254009A1 (en) * 2000-06-05 2008-10-16 Finegold Sydney M Method of treating gastrointestinal diseases associated with species of genus clostridium
US20080279839A1 (en) * 2005-11-01 2008-11-13 Christopher Schuler Composition With a Fungal (Yeast) Lipase and Method For Treating Lipid Malabsorption in Cystic Fibrous as Well as People Suffering From Pancreatic Lipase Insufficiency
US20080317731A1 (en) * 2002-04-19 2008-12-25 Diversa Corporation Phospholipases, Nucleic Acids Encoding Them and Methods for Making and Using Them

Family Cites Families (219)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE491927A (en) 1948-10-30
US3322626A (en) 1963-06-13 1967-05-30 Pannett Products Inc Medicinal composition for treating acne and method of using same
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
GB1429184A (en) 1972-04-20 1976-03-24 Allen & Hanburys Ltd Physically anti-inflammatory steroids for use in aerosols
US4044126A (en) 1972-04-20 1977-08-23 Allen & Hanburys Limited Steroidal aerosol compositions and process for the preparation thereof
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3786615A (en) 1972-11-13 1974-01-22 Pfizer Process for preparing pre-moistened antimicrobial towels
USRE28819E (en) 1972-12-08 1976-05-18 Syntex (U.S.A.) Inc. Dialkylated glycol compositions and medicament preparations containing same
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US3860708A (en) * 1973-11-15 1975-01-14 Philips Corp Method of delivering the intestines of human beings from bariumsulphate after barium meal examination
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
US4086257A (en) 1976-10-12 1978-04-25 Sears Barry D Phosphatidyl quaternary ammonium compounds
US4199322A (en) 1978-08-17 1980-04-22 The United States Of America As Represented By The Secretary Of Agriculture Antibacterial textile finishes utilizing zinc acetate and hydrogen peroxide
DE2923279B1 (en) 1979-06-08 1980-11-20 Kali Chemie Pharma Gmbh Process for the production of pancreatin pellets
US4410545A (en) 1981-02-13 1983-10-18 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4328245A (en) 1981-02-13 1982-05-04 Syntex (U.S.A.) Inc. Carbonate diester solutions of PGE-type compounds
US4432975A (en) 1981-04-13 1984-02-21 Icn Pharmaceuticals, Inc. Process for introducing vitamin B-12 into the bloodstream
US4358603A (en) 1981-04-16 1982-11-09 Syntex (U.S.A.) Inc. Acetal stabilized prostaglandin compositions
US4395454A (en) 1981-10-09 1983-07-26 Burlington Industries, Inc. Absorbent microbiocidal fabric and product
US4409239A (en) 1982-01-21 1983-10-11 Syntex (U.S.A.) Inc. Propylene glycol diester solutions of PGE-type compounds
EP0115023B1 (en) 1982-12-30 1988-07-27 Nordmark Arzneimittel GmbH Process for obtaining pancreatin
EP0133438A1 (en) 1983-01-21 1985-02-27 Advanced Drug Technology Corporation Enzyme ointment
US4447412A (en) 1983-02-01 1984-05-08 Bilton Gerald L Enzyme-containing digestive aid compostions
US4456544A (en) 1983-08-05 1984-06-26 Vsesojuzny Nauchno-Issledovatelsky Biotecknichesky Institut Enzyme-containing detergent composition for presterilization treatment of medical instruments and equipment
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5023108A (en) 1986-01-13 1991-06-11 Research Corporation Aqueous dispersions of waxes and lipids for pharmaceutical coating
JPS62230714A (en) 1986-03-31 1987-10-09 Snow Brand Milk Prod Co Ltd Enteric capsule
US4826679A (en) 1986-05-23 1989-05-02 Universite De Montreal Composition and methods for alleviating cystic fibrosis
US4710384A (en) 1986-07-28 1987-12-01 Avner Rotman Sustained release tablets made from microcapsules
DE3738599A1 (en) 1987-11-13 1989-05-24 Raps & Co Gewuerzwerk Encapsulated dried yeast in particle form, process for the production thereof and use thereof
WO1989008694A1 (en) 1988-03-14 1989-09-21 Novo-Nordisk A/S Granulate detergent enzyme product, method for production thereof, use thereof, and detergent containing such product
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
CN1039706A (en) 1988-08-04 1990-02-21 黄族和 The preparation method of artificial Fa vegetable
GB8821049D0 (en) 1988-09-08 1988-10-05 Health Lab Service Board Method & composition for treatment & prevention of viral infections
IT1229203B (en) 1989-03-22 1991-07-25 Bioresearch Spa USE OF 5 METHYLTHETRAHYDROPHOLIC ACID, 5 FORMYLTHETRAHYDROPHOLIC ACID AND THEIR PHARMACEUTICALLY ACCEPTABLE SALTS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS IN THE FORM OF CONTROLLED RELEASE ACTIVE IN THE THERAPY OF MENTAL AND ORGANIC DISORDERS.
GB8923788D0 (en) 1989-10-23 1989-12-13 Unilever Plc Enzymatic detergent compositions and their use
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
CA2037178A1 (en) 1990-02-28 1991-08-29 Albert Walter Brzeczko Deprenyl/l-dopa/carbidopa pharmaceutical composition
NO920067L (en) 1991-01-14 1992-07-15 Ajinomoto Kk FORADDITIVE FOR DRUGS
EP0511456A1 (en) 1991-04-30 1992-11-04 The Procter & Gamble Company Liquid detergents with aromatic borate ester to inhibit proteolytic enzyme
HU213044B (en) 1991-04-30 1997-01-28 Procter & Gamble Built liquid detergents with boric-polyol complex to inhibit proteolytic enzyme with additives improving detergent effect
JPH04364119A (en) 1991-06-11 1992-12-16 Tsumura & Co Bathing agent composition
IL99628A (en) 1991-10-02 2004-07-25 Yissum Res Dev Co Processes for the preparation of cyclic peptides, and pharmaceutical compositions containing them
JPH07501540A (en) 1991-11-25 1995-02-16 リチャードソン、ビックス、インコーポレーテッド Composition for regulating skin wrinkles and/or skin atrophy
US7242988B1 (en) 1991-12-23 2007-07-10 Linda Irene Hoffberg Adaptive pattern recognition based controller apparatus and method and human-factored interface therefore
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US6010715A (en) 1992-04-01 2000-01-04 Bertek, Inc. Transdermal patch incorporating a polymer film incorporated with an active agent
GB9207280D0 (en) 1992-04-02 1992-05-13 Unilever Plc Skin care method and composition
US6024975A (en) 1992-04-08 2000-02-15 Americare International Diagnostics, Inc. Method of transdermally administering high molecular weight drugs with a polymer skin enhancer
US5460812A (en) 1992-06-22 1995-10-24 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
DE4227385A1 (en) 1992-08-19 1994-02-24 Kali Chemie Pharma Gmbh Pancreatin micropellets
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
DE4305460C2 (en) 1993-02-23 1997-09-04 Albert Dr Scheller Pharmaceutical or cosmetic preparation containing enzymes, process for their preparation and their use
JPH06339343A (en) 1993-04-08 1994-12-13 Ajinomoto Co Inc Feed additive for ruminant
TW310277B (en) 1993-05-21 1997-07-11 Pou Lin Fu Gin Pharm Co The method of preparing enteric-coated pancreatin granules and its dosage forms
DE4332985A1 (en) 1993-09-28 1995-03-30 Konrad Peter Maria Dr Sommer Pharmaceutical composition for the treatment of exocrine pancreas dysfunction
GB9403250D0 (en) 1994-02-21 1994-04-13 Univ Mcgill Therapeutic use of myelin-associated glycoprotein (mag)
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
US20080311554A1 (en) 1994-05-06 2008-12-18 Slotman Gus J Methods for monitoring patients with severe sepsis and septic shock and for selecting treatments for these patients
IT1270594B (en) 1994-07-07 1997-05-07 Recordati Chem Pharm CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION OF LIQUID SUSPENSION MOGUISTEIN
US5476661A (en) 1994-10-21 1995-12-19 Elizabeth Arden Co., Division Of Conopco, Inc. Compositions for topical application to skin, hair and nails
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US5983134A (en) 1995-04-23 1999-11-09 Electromagnetic Bracing Systems Inc. Electrophoretic cuff apparatus drug delivery system
US6558708B1 (en) 1995-05-17 2003-05-06 Cedars-Sinai Medical Center Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
JPH11505258A (en) 1995-05-17 1999-05-18 セダーシナイ メディカル センター Compositions comprising fatty acids that improve digestion and absorption in the small intestine
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6562629B1 (en) 1999-08-11 2003-05-13 Cedars-Sinai Medical Center Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum
US5686255A (en) 1995-05-24 1997-11-11 Deth; Richard C. Compositions and methods for diagnosing schizophrenia
US6167301A (en) 1995-08-29 2000-12-26 Flower; Ronald J. Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
EP0884950B1 (en) 1996-03-06 2003-03-12 Novozymes A/S A method of killing or inhibiting microbial cells
US5985317A (en) 1996-09-06 1999-11-16 Theratech, Inc. Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
GB2318511A (en) 1996-10-23 1998-04-29 Eurand Int Process for the preparation of a pharmaceutical composition for rapid suspension in water
US5860932A (en) 1996-10-24 1999-01-19 Colin Corporation Blood pressure monitor
CA2190418A1 (en) 1996-11-15 1998-05-15 Zhi-Cheng Xiao Neuron and neural tumor growth regulatory system, antibodies thereto and uses thereof
US6100080A (en) 1996-12-18 2000-08-08 Novo Nordisk A/S Method for enzymatic treatment of biofilm
WO1998032336A2 (en) 1997-01-22 1998-07-30 Kerry Ingredients (Uk) Limited Enzyme-based bread improvers
US5860957A (en) 1997-02-07 1999-01-19 Sarcos, Inc. Multipathway electronically-controlled drug delivery system
CA2198317C (en) 1997-02-24 2003-01-07 Mouhsine El Abboudi Method for preparing pancreatin which contains low amounts of residual organic solvent and product thereof
CN1252877A (en) 1997-03-13 2000-05-10 第一咨询公司 Disease management system
US5858758A (en) 1997-05-07 1999-01-12 Incyte Pharmaceuticals, Inc. Human serine protease precursor
GB2347742B (en) 1997-06-05 2001-11-07 Royal Free Hosp School Med Pharmaceutical composition for RBD
US20010006644A1 (en) 1997-07-31 2001-07-05 David J. Bova Combinations of hmg-coa reductase inhibitors and nicotinic acid and methods for treating hyperlipidemia once a day at night
US5948433A (en) 1997-08-21 1999-09-07 Bertek, Inc. Transdermal patch
WO1999018920A1 (en) 1997-10-16 1999-04-22 Deguang Zhu A new powerful cosmetic or pharmaceutical composition
EP0968711B9 (en) 1997-10-28 2008-05-28 Bando Chemical Industries, Ltd. Dermatological patch sheet and process for producing base sheet therefor
KR19990072826A (en) 1998-02-26 1999-09-27 우재영 A process for producing enteric-coated pancreatin granules
EP1405570A1 (en) 1998-03-04 2004-04-07 Ajinomoto Co., Inc. Process for producing ruminant feed additive composition
US20010024660A1 (en) 1999-09-29 2001-09-27 Ismat Ullah Enteric coated pharmaceutical composition and method of manufacturing
JP5408684B2 (en) 1998-10-09 2014-02-05 ゼネラル ミルズ インコーポレイテッド Encapsulating sensitive liquid components in a matrix to obtain discontinuous storage stable particles
US6149585A (en) 1998-10-28 2000-11-21 Sage Health Management Solutions, Inc. Diagnostic enhancement method and apparatus
US6168569B1 (en) 1998-12-22 2001-01-02 Mcewen James Allen Apparatus and method for relating pain and activity of a patient
US6753306B2 (en) 1998-12-23 2004-06-22 Joseph J. Simpson Germicidal and disinfectant composition
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
DK1162995T3 (en) 1999-03-17 2003-06-23 Solvay Pharm Gmbh Enzymes for the treatment of type I diabetes mellitus
US7945451B2 (en) 1999-04-16 2011-05-17 Cardiocom, Llc Remote monitoring system for ambulatory patients
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
JP2003502071A (en) 1999-06-18 2003-01-21 ブジャーナソン・ヨーン・ブラーギ Fish serine proteinases and their use in medicines and cosmetics
US7395216B2 (en) 1999-06-23 2008-07-01 Visicu, Inc. Using predictive models to continuously update a treatment plan for a patient in a health care location
JP4834266B2 (en) 1999-08-13 2011-12-14 インタラクティブ メトロノーム， インコーポレイテッド Method and apparatus for improving learning ability
IL131508A (en) 1999-08-19 2006-12-10 David Cohen Microencapsulated and controlled-release formulations of isoflavone from enriched fractions of soy and other plants
US6447772B1 (en) 1999-10-01 2002-09-10 Klaire Laboratories, Inc. Compositions and methods relating to reduction of symptoms of autism
US20020103675A1 (en) 1999-11-29 2002-08-01 John Vanelli Apparatus and method for providing consolidated medical information
US6564104B2 (en) 1999-12-24 2003-05-13 Medtronic, Inc. Dynamic bandwidth monitor and adjuster for remote communications with a medical device
US6980958B1 (en) 2000-01-11 2005-12-27 Zycare, Inc. Apparatus and methods for monitoring and modifying anticoagulation therapy of remotely located patients
US20020068857A1 (en) 2000-02-14 2002-06-06 Iliff Edwin C. Automated diagnostic system and method including reuse of diagnostic objects
US6312741B1 (en) 2000-02-22 2001-11-06 Balchem Corporation Encapsulated food acids for preservation of baked goods
US6261595B1 (en) 2000-02-29 2001-07-17 Zars, Inc. Transdermal drug patch with attached pocket for controlled heating device
US7379885B1 (en) 2000-03-10 2008-05-27 David S. Zakim System and method for obtaining, processing and evaluating patient information for diagnosing disease and selecting treatment
CA2342121C (en) * 2000-03-29 2010-05-25 Roquette Freres Powdered mannitol and the procedure for preparing it
US6399114B2 (en) 2000-05-26 2002-06-04 C & D Foreman, Inc. Nutritional system for nervous system disorders
US6783757B2 (en) 2000-06-01 2004-08-31 Kirkman Group, Inc. Composition and method for increasing exorphin catabolism to treat autism
AUPQ899700A0 (en) * 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
WO2002019828A1 (en) 2000-09-08 2002-03-14 Novozymes A/S A dough composition comprising a lipid-encapsulated enzyme
US20020094367A1 (en) 2000-09-08 2002-07-18 Novozymes A/S Dough composition
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20020119914A1 (en) 2000-12-26 2002-08-29 Deguang Zhu New uses of insulin and pancreatin
US6548556B2 (en) 2000-12-27 2003-04-15 Healthpoint, Ltd. Stable enzymatic wound debrider
CN1150032C (en) 2001-01-15 2004-05-19 孙芳梅 Concentrated granular medicine for treating baby diarrhea and its preparing process
AR032392A1 (en) 2001-01-19 2003-11-05 Solvay Pharm Gmbh ENZYMES MIX, PHARMACEUTICAL PREPARATION AND USE OF PREPARED SAID.
US7588757B2 (en) 2001-03-14 2009-09-15 Genzyme Corporation Methods of treating Parkinson's disease using recombinant adeno-associated virus virions
US7232670B2 (en) 2001-09-28 2007-06-19 St. Jude Children's Research Hospital Targeting proteins to cells expressing mannose receptors via expression in insect cells
US7630911B2 (en) 2001-10-24 2009-12-08 Qtc Management, Inc. Method of automated processing of medical data for insurance and disability determinations
AU2002364750A1 (en) 2001-12-14 2003-06-30 Solvay Pharmaceuticals Gmbh Use of digestive enzyme mixtures for treating pathological bacterial overgrowth of the small intestine of mammals and humans
US6616954B1 (en) 2002-03-14 2003-09-09 Balchem Corporation Solvent released encapsulated yeast
EP1503715A4 (en) 2002-05-03 2005-07-06 Martek Biosciences Corp High-quality lipids and methods for producing by enzymatic liberation from biomass
US20040005304A1 (en) 2002-07-08 2004-01-08 Mak Wood, Inc. Novel compositions and methods for treating neurological disorders and associated gastrointestinal conditions
EP1413202A1 (en) 2002-10-22 2004-04-28 CSM Nederland B.V. Lipid-encapsulated functional bakery ingredients
US20050079594A1 (en) 2002-10-31 2005-04-14 Karine Marion Method of removing a biofilm
US8946151B2 (en) 2003-02-24 2015-02-03 Northern Bristol N.H.S. Trust Frenchay Hospital Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen
US20070042143A1 (en) 2003-04-23 2007-02-22 Ferring B.V. Sachet for a pharmaceutical composition
US7780595B2 (en) 2003-05-15 2010-08-24 Clinical Decision Support, Llc Panel diagnostic method and system
MXPA05012317A (en) 2003-05-16 2006-01-30 Pfizer Prod Inc Therapeutic combinations of atypical antipsychotics with gaba modulators, anticonvulsants or benzodiazapines.
CN100487098C (en) 2003-06-05 2009-05-13 柯积发 Nanometer antibacterial non-phosphate washing powder
ES2339351T3 (en) 2003-06-19 2010-05-19 Nicholas S. Bodor IMPROVEMENT OF THE ACTIVITY AND / OR DURATION OF THE ACTION OF SOFT ANTI-INFLAMMATORY STEROIDS FOR TOPICAL OR OTHER LOCAL APPLICATION.
US7289761B2 (en) 2003-06-23 2007-10-30 Cardiac Pacemakers, Inc. Systems, devices, and methods for selectively preventing data transfer from a medical device
US7354569B2 (en) 2003-07-11 2008-04-08 Colgate-Palmolive Company Chewable antiplaque confectionery dental composition
EP1651962B1 (en) 2003-07-29 2013-09-11 Abbott Laboratories GmbH Analytical method for pancreatin and comparable compositions
US7785584B2 (en) 2003-08-13 2010-08-31 Healthpoint, Ltd. Ointment wound spray
RU2370279C2 (en) 2003-09-23 2009-10-20 ДСМ Ай Пи ЭССЕТС Б.В. Application of proline-specific endoproteses for peptide and protein hydrolysis
US7381698B2 (en) 2003-12-12 2008-06-03 Chirhoclin, Inc. Methods for treatment of acute pancreatitis
CN1933850B (en) 2004-03-22 2011-01-12 索尔瓦药物有限公司 Oral pharmaceutical compositions of lipase-containing products, in particular of pancreatin, containing surfactants
US20050232894A1 (en) 2004-04-20 2005-10-20 Weiner Gregory M Antimicrobial skin treatment composition and methods for producing and using an antimicrobial skin treatment composition
MXPA06013239A (en) 2004-05-24 2007-02-28 Novozymes As Enzymes for pharmaceutical use.
ITTO20040390A1 (en) 2004-06-10 2004-09-10 Roeder 1956 Farmaceutici S P A COMPOSITION, IN PARTICULAR FOR PHARMACEUTICAL USE, WITH ANTIOXIDANT, ANTI-INFLAMMATORY AND IMMUNOSTIMULATING ACTION.
CN1997352B (en) 2004-06-17 2010-12-01 天野酶制品美国有限公司 Controlled release formulations of enzymes, microorganisms, and antibodies with mucoadhesive polymers
WO2006019764A2 (en) 2004-07-15 2006-02-23 Northstar Neuroscience, Inc. Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy
CN101040052A (en) 2004-09-10 2007-09-19 诺维信北美公司 Methods for preventing, removing, reducing, or disrupting biofilm
CN101068565B (en) 2004-10-14 2010-11-17 胞囊纤维化基础治疗公司 Compositions containing lipase, protease and amylase for treating pancreatic insufficiency
CN101039667A (en) 2004-10-15 2007-09-19 辉瑞大药厂 Treatment of bipolar disorders and associated symptoms
US20060115467A1 (en) 2004-12-01 2006-06-01 Pangborn Jon B Compositions and methods for the treatment of autism
EP1861009B1 (en) 2005-03-17 2019-05-22 Robert E. Coifman Apparatus and method for intelligent electronic peak flow meters
US20060294108A1 (en) 2005-04-14 2006-12-28 Adelson Alex M System for and method of managing schedule compliance and bidirectionally communicating in real time between a user and a manager
US20070092501A1 (en) 2005-04-26 2007-04-26 Prothera, Inc. Compositions and methods relating to reduction of symptoms of autism
US20060258599A1 (en) 2005-04-27 2006-11-16 Melanie Childers Methods and composition for the treatment of cystic fibrosis and related illnesses
US20060276412A1 (en) 2005-05-31 2006-12-07 Gary Tollefson Methods and compositions for managing psychotic disorders
WO2007002572A2 (en) 2005-06-24 2007-01-04 N-Zymeceuticals, Inc. Nattokinase for reducing whole blood viscosity
EP1913138B1 (en) 2005-07-29 2016-08-24 Abbott Laboratories GmbH Processes for the manufacture of pancreatin powder with low virus content
WO2007020260A2 (en) 2005-08-15 2007-02-22 Solvay Pharmaceuticals Gmbh Pancreatin micropellet cores suitable for enteric coating
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
US20070116695A1 (en) 2005-09-21 2007-05-24 Fallon Joan M Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
US20100196344A1 (en) 2005-10-14 2010-08-05 Cystic Fibrosis Foundation Therapeutics, Inc. Compositions and methods for treating pancreatic insufficiency
US20070203426A1 (en) 2005-10-20 2007-08-30 Kover Arthur J Method and apparatus for obtaining real time emotional response data over a communications network
US8728521B2 (en) 2005-12-27 2014-05-20 Hemant N. Joshi Physically/molecularly distributed and/or chemically bound medicaments in empty, hard capsule shells
ES2763724T3 (en) 2005-12-27 2020-05-29 Univ Ramot Stable enzyme preparations and methods of using them
US20090304670A1 (en) 2006-02-02 2009-12-10 Luppo Edens Food product comprising a proline specific protease, the preparation thereof and its use for degrading toxic or allergenic gluten peptides
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
KR20090034350A (en) 2006-06-23 2009-04-07 바셀 폴리올레핀 이탈리아 에스.알.엘 Magnesium chloroalkolate-based catalyst precursors
US8287858B2 (en) 2006-08-10 2012-10-16 Jon Barron Proteolytic enzyme formulations
WO2008028193A2 (en) 2006-09-01 2008-03-06 Pharmion Corporation Colon-targeted oral formulations of cytidine analogs
DE102006053071A1 (en) 2006-11-10 2008-05-15 Ab Enzymes Gmbh Protein-containing substance with increased temperature stability
US8066986B2 (en) 2007-02-01 2011-11-29 Master Supplements, Inc. Formulations including digestive enzymes and polysorbate surfactants that enhance the colonization of administered probiotics microoganisms
US20080199448A1 (en) 2007-02-16 2008-08-21 Ross Mairi R Enzyme composition for improving food digestion
MY163469A (en) 2007-02-20 2017-09-15 Allergan Therapeutics LLC Stable digestive enzyme compositions
US20090117180A1 (en) 2007-02-20 2009-05-07 Giovanni Ortenzi Stable digestive enzyme compositions
AU2008239737A1 (en) 2007-04-13 2008-10-23 Beth Israel Deaconess Medical Center, Inc. Novel nutritional food products for improved digestion and intestinal absorption
JP2008283895A (en) 2007-05-16 2008-11-27 Osaka City Univ Method for detecting diarrheagenic escherichia coli
US20090004285A1 (en) 2007-06-29 2009-01-01 Liangping Yu Stable non-disintegrating dosage forms and method of making same
US20110065628A1 (en) 2007-08-27 2011-03-17 University Of Virginia Patent Foundation Medication Combinations for the Treatment of Alcoholism and Drug Addiction
US20090063402A1 (en) 2007-08-31 2009-03-05 Abbott Diabetes Care, Inc. Method and System for Providing Medication Level Determination
US20090110674A1 (en) 2007-10-24 2009-04-30 Loizou Nicos C Health supplement
RU2356244C1 (en) 2007-11-12 2009-05-27 Федеральное государственное учреждение "Томский научно-исследовательский институт курортологии и физиотерапии Федерального агентства по здравоохранению и социальному развитию" (ФГУ "ТНИИКиФ Росздрава") Combination therapy of children suffering from celiac disease at health resort stage
US20090171696A1 (en) 2008-01-02 2009-07-02 David Joseph Allard System and method for patient portal with clinical decision intelligence
US10087493B2 (en) 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8976007B2 (en) 2008-08-09 2015-03-10 Brian M. Dugan Systems and methods for providing biofeedback information to a cellular telephone and for using such information
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
EP2300603A4 (en) 2008-06-24 2011-08-03 Micropharma Ltd Nitric oxide device and method for wound healing, treatment of dermatological disorders and microbial infections
US20090324730A1 (en) 2008-06-26 2009-12-31 Fallon Joan M Methods and compositions for the treatment of symptoms of complex regional pain syndrome
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
EP2318035B1 (en) 2008-07-01 2019-06-12 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
EP2328609A1 (en) 2008-08-26 2011-06-08 Cystic Fibrosis Foundation Therapeutics, Inc. Rapidly disintegrating tablets comprising lipase, amylase, and protease
US20100092447A1 (en) 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
ATE541591T1 (en) 2008-11-03 2012-02-15 Nordmark Arzneimittel Gmbh & Co Kg METHOD FOR REDUCING THE VIRAL AND MICROBIAL LOAD OF PANCREATIN
US9107419B2 (en) 2009-01-06 2015-08-18 Curelon Llc Compositions and methods for treatment or prevention of Staphylococcus aureus infections and for the eradication or reduction of Staphylococcus aureus on surfaces
EP2947100B1 (en) 2009-01-06 2019-05-08 Galenagen, LLC Oral compositions for the treatment or the prevention of infections by E. Coli
JP2012518655A (en) 2009-02-23 2012-08-16 アプタリス ファーマテック インコーポレイテッド Controlled release composition comprising a proton pump inhibitor
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
WO2011000924A1 (en) 2009-07-03 2011-01-06 Abbott Products Gmbh Spray-dried amylase, pharmaceutical preparations comprising the same and use
PL2295039T5 (en) 2009-08-28 2023-02-27 Nordmark Pharma Gmbh Method of preparing pancreatin pellets, in particular pancreatin micropellets, and pancreatin pellets prepared thereby
US20110081320A1 (en) 2009-10-06 2011-04-07 Nubiome, Inc. Treatment/Cure of Autoimmune Disease
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
US20110112005A1 (en) 2009-11-12 2011-05-12 Alan Thomas Brooker Laundry Detergent Composition
LT2523661T (en) 2010-01-15 2017-08-10 INSERM (Institut National de la SantƩ et de la Recherche MƩdicale) Nkcc inhibitors for the treatment of autism
EP2531521B1 (en) 2010-02-02 2017-09-06 Amano Enzyme USA., Ltd. Use of proteases for gluten intolerance
AU2011228744A1 (en) 2010-03-19 2012-10-11 Aptalis Pharma Canada Inc. Beta-propiolactone for inactivation of viruses in pharmaceutical pancreatic enzyme preparations
UA111726C2 (en) 2010-10-01 2016-06-10 Апталіс Фарма Лімітед LOW FORCE PANCRELIPASE PREPARATION WITH INTRA-SOLID COVERING
CA2815044A1 (en) 2010-11-19 2012-05-24 Curemark Llc Preparation and use of combination enzyme and gastrointestinal modulator delivery systems
BR112013017283A2 (en) 2011-01-10 2016-10-25 Cleveland Biolabs Inc use of toll-like receptor agonist for cancer treatment
MX362974B (en) 2011-04-21 2019-02-28 Curemark Llc Compounds for the treatment of neuropsychiatric disorders.
BR112014016557A8 (en) 2012-01-03 2017-07-04 Curemark Llc Methods of treating behavioral symptoms of neurological and mental disorders
WO2013116732A1 (en) 2012-02-02 2013-08-08 Curelon Llc Enzyme compositions and use thereof for wound healing
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease

Patent Citations (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3002883A (en) * 1959-07-29 1961-10-03 Dow Chemical Co Disinfectant compositions
US3223594A (en) * 1960-10-25 1965-12-14 Philips Corp Method of producing pancreatin
US3357894A (en) * 1963-10-18 1967-12-12 Ct Nat De La Recherche Proteolytic enzymes of pig pancreas
US3515642A (en) * 1965-12-06 1970-06-02 Takeda Chemical Industries Ltd Method for preparing a stabilized enzyme composition
US3574819A (en) * 1966-12-08 1971-04-13 Ciba Geigy Corp Pharmaceutical compositions for treating digestive disorders containing 4,7- phenanthrolin - 5,6 - quinone together with pancreatin,bromelin,dehydrocholic acid and 7 - iodo - 5 - chloro-8-hydroxyquinoline
US3940478A (en) * 1974-04-29 1976-02-24 Sutures, Inc. Proteolytic enzymes as adjuncts to antibiotic prophylaxis of contaminated wounds
US4079125A (en) * 1975-06-10 1978-03-14 Johnson & Johnson Preparation of enteric coated digestive enzyme compositions
US4241046A (en) * 1978-11-30 1980-12-23 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US5250418A (en) * 1981-10-06 1993-10-05 Boehringer Mannheim Gmbh Process and reagent for determining the activity of chymotrypsin and trypsin in feces
US6309669B1 (en) * 1984-03-16 2001-10-30 The United States Of America As Represented By The Secretary Of The Army Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix
US5436319A (en) * 1985-12-03 1995-07-25 T Cell Sciences, Inc. Cell free T cell antigen receptor beta chain and its clinical utilities
US5674532A (en) * 1989-11-24 1997-10-07 Biochemie Gesellschaft M.B.H. Pancreatin preparations
US6011001A (en) * 1990-08-03 2000-01-04 Vertex Pharmaceuticals, Inc. Method of protein therapy by orally administering crosslinked protein crystals
US5190775A (en) * 1991-05-29 1993-03-02 Balchem Corporation Encapsulated bioactive substances
US5607863A (en) * 1991-05-29 1997-03-04 Smithkline Diagnostics, Inc. Barrier-controlled assay device
US6013286A (en) * 1991-05-29 2000-01-11 Balchem Corporation Encapsulated bioactive substances
US5648335A (en) * 1992-06-12 1997-07-15 Cephalon, Inc. Prevention and treatment of peripheral neuropathy
US5324514A (en) * 1992-06-22 1994-06-28 Digestive Care Inc. Compositions of digestive enzymes and salts of bile acids and process for preparation thereof
US5437319A (en) * 1992-08-28 1995-08-01 Black & Decker Inc. Pivoting power tool with table
US5527678A (en) * 1994-10-21 1996-06-18 Vanderbilt University CagB and CagC genes of helicobacter pylori and related compositions
US5985891A (en) * 1994-12-29 1999-11-16 Rowe; James Baber Prevention of adverse behavior, diarrhea, skin disorders and infections of the hind gut associated with acidic conditions in humans and animals by the application of antibiotics
US5686311A (en) * 1995-06-23 1997-11-11 The Children's Mercy Hospital Diagnosis of autism and treatment therefor
US6280726B1 (en) * 1995-07-21 2001-08-28 New York University Type II phospholipase A2 and its use in killing Gram-positive bacteria
US6852487B1 (en) * 1996-02-09 2005-02-08 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
US5958875A (en) * 1996-03-29 1999-09-28 The Regents Of The University Of California Synthetic peptides derivatives with nerve growth factor-like neurotrophic activity
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
US5952178A (en) * 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6020310A (en) * 1997-05-19 2000-02-01 Repligen Corporation Method for assisting in differential diagnosis and treatment of autistic syndromes
US6482839B1 (en) * 1997-06-02 2002-11-19 Cellegy Pharmaceuticals, Inc. Pyridine-thiols for treatment of a follicular dermatosis
US6534259B1 (en) * 1997-06-05 2003-03-18 Andrew Wakefield Regressive behavioral disorder diagnosis
US6197746B1 (en) * 1998-05-19 2001-03-06 Repligen Corporation Method of using secretin for treating autism
US6020314A (en) * 1998-08-11 2000-02-01 Milkhaus Laboratory, Inc. Methods for treatment of neurological disorders
US6210950B1 (en) * 1999-05-25 2001-04-03 University Of Medicine And Dentistry Of New Jersey Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors
US6153236A (en) * 1999-06-03 2000-11-28 Balchem Corporation Low melt encapsulation with high laurate canola oil
US6187309B1 (en) * 1999-09-14 2001-02-13 Milkaus Laboratory, Inc. Method for treatment of symptoms of central nervous system disorders
US7129053B1 (en) * 1999-10-12 2006-10-31 Dakocytomation Denmark A/S Immuno-chromatographic rapid assay in order to detect acid-resistant microorganisms in the stool
US6727073B1 (en) * 1999-11-19 2004-04-27 Binax, Inc. Method for detecting enteric disease
US20060183180A1 (en) * 1999-12-17 2006-08-17 Fallon Joan M Methods for treating pervasive development disorders
US6534063B1 (en) * 1999-12-17 2003-03-18 Joan M. Fallon Methods for treating pervasive development disorders
US6251478B1 (en) * 1999-12-22 2001-06-26 Balchem Corporation Sensitive substance encapsulation
US6261613B1 (en) * 2000-02-15 2001-07-17 General Mills, Inc. Refrigerated and shelf-stable bakery dough products
US6399101B1 (en) * 2000-03-30 2002-06-04 Mova Pharmaceutical Corp. Stable thyroid hormone preparations and method of making same
US20040209790A1 (en) * 2000-04-07 2004-10-21 Alex Sava Process and composition for cleaning medical instruments
US20080254009A1 (en) * 2000-06-05 2008-10-16 Finegold Sydney M Method of treating gastrointestinal diseases associated with species of genus clostridium
US7138123B2 (en) * 2000-08-14 2006-11-21 Fallon Joan M Methods for diagnosing and treating dysautonomia and other dysautonomic conditions
US20020037284A1 (en) * 2000-08-14 2002-03-28 Fallon Joan M. Method for diagnosing and treating dysautonomia and other dysautonomic conditions
US20070053895A1 (en) * 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
US6660831B2 (en) * 2000-08-14 2003-12-09 Joan M. Fallon Method for diagnosing and treating dysautonomia and other dysautonomic conditions
US20040101562A1 (en) * 2000-11-15 2004-05-27 Mario Maio Microspheres of pancreatic enzymes with high stability and production method thereof
US20040057962A1 (en) * 2001-01-06 2004-03-25 Benedikt Timmerman Immunogenic complex
US20030097122A1 (en) * 2001-04-10 2003-05-22 Ganz Robert A. Apparatus and method for treating atherosclerotic vascular disease through light sterilization
US20060105379A1 (en) * 2001-04-26 2006-05-18 Shujian Wu Polynucleotide encoding a novel metalloprotease highly expressed in the testis, MMP-29
US7101573B2 (en) * 2001-09-28 2006-09-05 Mcneil-Pcc, Inc. Simethicone solid oral dosage form
US6797291B2 (en) * 2002-01-09 2004-09-28 Balchem Corporation Stable hygroscopic compositions and methods for stabilizing hygroscopic ingredients
US20080317731A1 (en) * 2002-04-19 2008-12-25 Diversa Corporation Phospholipases, Nucleic Acids Encoding Them and Methods for Making and Using Them
US20040076590A1 (en) * 2002-07-08 2004-04-22 Wilkins Joe S. Antibacterial toothpaste and mouthwash formulations
US20060259995A1 (en) * 2002-10-10 2006-11-16 Diversa Corporation Proteases, nucleic acids encoding them and methods for making and using them
US20040121002A1 (en) * 2002-12-23 2004-06-24 Lee Phillip K. Controlled release encapsulated bioactive substances
US6835397B2 (en) * 2002-12-23 2004-12-28 Balchem Corporation Controlled release encapsulated bioactive substances
US20050187130A1 (en) * 2004-02-23 2005-08-25 Brooker Alan T. Granular laundry detergent composition comprising an anionic detersive surfactant, and low levels of, or no, zeolite builders and phosphate builders
US20080166334A1 (en) * 2004-09-28 2008-07-10 Fallon Joan M Combination enzyme for cystic fibrosis
US20080279839A1 (en) * 2005-11-01 2008-11-13 Christopher Schuler Composition With a Fungal (Yeast) Lipase and Method For Treating Lipid Malabsorption in Cystic Fibrous as Well as People Suffering From Pancreatic Lipase Insufficiency

Cited By (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163278B2 (en) 1999-12-17 2012-04-24 Curemark Llc Methods for treating pervasive development disorders
US8815233B2 (en) 1999-12-17 2014-08-26 Curemark Llc Method for treating pervasive development disorders
US8613918B2 (en) 1999-12-17 2013-12-24 Curemark Llc Method for treating pervasive development disorders
US8105584B2 (en) 1999-12-17 2012-01-31 Curemark Llc Method for treating pervasive development disorders
US20080219966A1 (en) * 1999-12-17 2008-09-11 Fallon Joan M Methods of treating pervasive development disorders
US20090197289A1 (en) * 1999-12-17 2009-08-06 Fallon Joan M Method for confirming a diagnosis of autism
US9624526B2 (en) 1999-12-17 2017-04-18 Curemark Llc Method for treating pervasive development disorders
US9624525B2 (en) 1999-12-17 2017-04-18 Curemark, Llc Method for treating pervasive development disorders
US8211661B2 (en) 1999-12-17 2012-07-03 Curemark, Llc Method for identifying individuals having a pervasive development disorder amenable to digestive enzyme therapy
US20090286270A1 (en) * 1999-12-17 2009-11-19 Fallon Joan M Method for treating pervasive development disorders
US20040071683A1 (en) * 1999-12-17 2004-04-15 Fallon Joan M. Methods for treating pervasive development disorders
US8012930B2 (en) 1999-12-17 2011-09-06 Curemark, Llc Methods of treating pervasive development disorders
US8008036B2 (en) 1999-12-17 2011-08-30 Curemark, Llc Method for identifying autistic individuals amenable to digestive enzyme therapy
US8778335B2 (en) 2000-08-14 2014-07-15 Curemark, Llc Methods of treating and diagnosing Parkinson's disease and related dysautonomic disorders
US8012710B2 (en) 2000-08-14 2011-09-06 Curemark, Llc Methods of treating and diagnosing Parkinsons disease and related dysautonomic disorders
US20070053895A1 (en) * 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
US9233146B2 (en) 2000-08-14 2016-01-12 Curemark, Llc Method of treating and diagnosing Parkinson's disease and related dysautonomic disorders
US20090285790A1 (en) * 2000-08-14 2009-11-19 Fallon Joan M Methods of treating and diagnosing parkinsons disease and related dysautonomic disorders
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US8921054B2 (en) 2000-11-16 2014-12-30 Curemark, Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20020081628A1 (en) * 2000-11-16 2002-06-27 Fallon Joan M. Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US10209253B2 (en) 2000-11-16 2019-02-19 Curemark, Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US8580522B2 (en) 2000-11-16 2013-11-12 Curemark, Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US9377459B2 (en) 2000-11-16 2016-06-28 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
US20080166334A1 (en) * 2004-09-28 2008-07-10 Fallon Joan M Combination enzyme for cystic fibrosis
US20100233218A1 (en) * 2004-09-28 2010-09-16 Curemark Llc Combination enzyme for cystic fibrosis
US8673877B2 (en) 2005-08-30 2014-03-18 Curemark, Llc Use of lactulose in the treatment of autism
US11033563B2 (en) 2005-08-30 2021-06-15 Curemark, Llc Use of lactulose in the treatment of autism
US10350229B2 (en) 2005-08-30 2019-07-16 Curemark, Llc Use of lactulose in the treatment of autism
US9345721B2 (en) 2005-08-30 2016-05-24 Curemark, Llc Use of lactulose in the treatment of autism
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US9925250B2 (en) 2008-03-13 2018-03-27 Curemark, Llc Method of treating proteinuria in pregnancy
US11045527B2 (en) 2008-03-13 2021-06-29 Curemark, Llc Method of diagnosing preeclampsia or pregnancy-induced hypertension
US9023344B2 (en) 2008-03-13 2015-05-05 Curemark, Llc Method of treating toxemia
US20090232789A1 (en) * 2008-03-13 2009-09-17 Fallon Joan M Novel pharmaceutical preparation for preeclampsia, eclampsia, and toxemia, and their related symptoms and related disorders of pregnancy
US9408895B2 (en) 2008-03-13 2016-08-09 Curemark, Llc Method of treating pregnancy-induced hypertension
US10272141B2 (en) 2008-04-18 2019-04-30 Curemark, Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US9687534B2 (en) 2008-04-18 2017-06-27 Curemark, Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US11235038B2 (en) 2008-04-18 2022-02-01 Curemark, Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US20090263372A1 (en) * 2008-04-18 2009-10-22 Fallon Joan M Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US8486390B2 (en) 2008-04-18 2013-07-16 Curemark Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US8318158B2 (en) 2008-04-18 2012-11-27 Curemark, Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US8084025B2 (en) 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US9017665B2 (en) 2008-04-18 2015-04-28 Curemark, Llc Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US10588948B2 (en) 2008-06-26 2020-03-17 Curemark, Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
US11016104B2 (en) 2008-07-01 2021-05-25 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US20100169409A1 (en) * 2008-08-04 2010-07-01 Fallon Joan M Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of parkinsons disease, movement and neurological disorders, and chronic pain
US10776453B2 (en) 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
US9687535B2 (en) 2008-10-03 2017-06-27 Curemark, Llc Methods and compositions for the treatment of symptoms of prion diseases
US10413601B2 (en) 2008-10-03 2019-09-17 Curemark, Llc Methods and compositions for the treatment of symptoms of prion diseases
US9061033B2 (en) 2008-10-03 2015-06-23 Curemark Llc Methods and compositions for the treatment of symptoms of prion diseases
US10736946B2 (en) 2009-01-06 2020-08-11 Galenagen, Llc Compositions and methods for treatment or prevention of Staphylococcus aureus infections and for the eradication or reduction of Staphylococcus aureus on surfaces
US9107419B2 (en) 2009-01-06 2015-08-18 Curelon Llc Compositions and methods for treatment or prevention of Staphylococcus aureus infections and for the eradication or reduction of Staphylococcus aureus on surfaces
US11357835B2 (en) 2009-01-06 2022-06-14 Galenagen, Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
US9895427B2 (en) 2009-01-06 2018-02-20 Galenagen, Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
US9084784B2 (en) 2009-01-06 2015-07-21 Curelon Llc Compositions and methods for the treatment or the prevention of E. coli infections and for the eradication or reduction of E. coli surfaces
US9415014B2 (en) 2009-04-13 2016-08-16 Curemark, Llc Enzyme delivery systems and methods of preparation and use
US9931302B2 (en) 2009-04-13 2018-04-03 Curemark , LLC Enzyme delivery systems and methods of preparation and use
US11419821B2 (en) 2009-04-13 2022-08-23 Curemark, Llc Enzyme delivery systems and methods of preparation and use
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
US10098844B2 (en) 2009-04-13 2018-10-16 Curemark, Llc Enzyme delivery systems and methods of preparation and use
US10716835B2 (en) 2009-10-21 2020-07-21 Curemark, Llc Methods and compositions for the prevention and treatment of influenza
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
US8980252B2 (en) 2011-04-21 2015-03-17 Curemark Llc Methods of treatment of schizophrenia
US10940187B2 (en) 2011-04-21 2021-03-09 Curemark, Llc Method of treatment of schizophreniform disorder
US9492515B2 (en) 2011-04-21 2016-11-15 Curemark, Llc Method of treatment of schizophreniform disorder
US10279016B2 (en) 2011-04-21 2019-05-07 Curemark, Llc Method of treatment of schizophreniform disorder
US9385259B2 (en) 2011-12-06 2016-07-05 Solarworld Innovations Gmbh Method for manufacturing a metallization structure comprising aluminum and silicon
US11364287B2 (en) 2012-05-30 2022-06-21 Curemark, Llc Methods of treating celiac disease
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses

Also Published As

Publication number Publication date
US10350229B2 (en) 2019-07-16
US20210252031A1 (en) 2021-08-19
US20120004192A1 (en) 2012-01-05
US20190275066A1 (en) 2019-09-12
US20160213697A1 (en) 2016-07-28
US9345721B2 (en) 2016-05-24
US20140187512A1 (en) 2014-07-03
US20080058282A1 (en) 2008-03-06
US8673877B2 (en) 2014-03-18
US11033563B2 (en) 2021-06-15

Similar Documents

Publication Publication Date Title
US11033563B2 (en) Use of lactulose in the treatment of autism
CN111050764A (en) β -hydroxybutyrate and butanediol S enantiomers and methods of use thereof
US9415030B2 (en) High-dose glycine as a treatment for obsessive-compulsive disorder and obsessive-compulsive spectrum disorders
Fallon Could one of the most widely prescribed antibiotics amoxicillin/clavulanate “augmentin™” be a risk factor for autism?
KR20200138333A (en) Compositions and methods for treating inflammatory bowel disease
KR20190086382A (en) Nanovesicles derived from Faecalibacterium prausnitzii and Use thereof
US20210330729A1 (en) Dietary fiber compositions
Kaplan et al. Juvenile acute intermittent porphyria with hypercholesterolemia and epilepsy: a case report and review of the literature
JP3884611B2 (en) Improving agent for impulsive disease
CN102292090B (en) Composition for mitochondrial activation
WO2000033850A1 (en) Remedies for hyperammonemia
Mammadova et al. Antibiotics and side effect of theirs
JP6457687B1 (en) Pharmaceutical composition for inhibiting PDE5 and food composition for inhibiting PDE5
RU2437663C2 (en) Method of correcting intestinal microflora
Kutsenko et al. Study on anti-fungal drug activity against clinically isolated strains of oral Сandida species
JP2012224589A (en) Carbohydrate absorption inhibitor
CN115590865B (en) Application of brown alginate oligosaccharides in preparation of product for improving intestinal flora disorder
RU2444353C2 (en) Method of treating generalised vasculitis accompanying neuroinfections in children
RU2799556C2 (en) Compositions and methods of the treatment of inflammatory diseases of the intestine
Yang et al. Effect of Lacticaseibacillus Paracasei Strain Shirota Supplementation on Clinical Responses, Gut Microbiota and Faecal Metabolites in Patients with Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled Trial
CN1487834A (en) Method for alleviating syndromes and conditions of discomfort of the mammalian intestinal and genito-urinary tracts
Kharb et al. Bitterness suppression of oral pharmaceuticals
US20230053227A1 (en) Dietary fiber compositions
Trauer et al. The syndrome of inappropriate anti-diuretic hormone secretion concurrent with an acute exacerbation of cystic fibrosis
CN114828656A (en) Full calorie, slowly digestible carbohydrate composition

Legal Events

Date Code Title Description
AS Assignment

Owner name: CUREMARK, LLC, NEW YORK

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FALLON, JOAN M.;REEL/FRAME:022626/0948

Effective date: 20090408

STCB Information on status: application discontinuation

Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION