US20070288009A1 - Dynamic spinal stabilization device - Google Patents
Dynamic spinal stabilization device Download PDFInfo
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- US20070288009A1 US20070288009A1 US11/728,204 US72820407A US2007288009A1 US 20070288009 A1 US20070288009 A1 US 20070288009A1 US 72820407 A US72820407 A US 72820407A US 2007288009 A1 US2007288009 A1 US 2007288009A1
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- spinal stabilization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7002—Longitudinal elements, e.g. rods
- A61B17/7019—Longitudinal elements having flexible parts, or parts connected together, such that after implantation the elements can move relative to each other
- A61B17/7023—Longitudinal elements having flexible parts, or parts connected together, such that after implantation the elements can move relative to each other with a pivot joint
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7002—Longitudinal elements, e.g. rods
- A61B17/7014—Longitudinal elements, e.g. rods with means for adjusting the distance between two screws or hooks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7002—Longitudinal elements, e.g. rods
- A61B17/7019—Longitudinal elements having flexible parts, or parts connected together, such that after implantation the elements can move relative to each other
- A61B17/7025—Longitudinal elements having flexible parts, or parts connected together, such that after implantation the elements can move relative to each other with a sliding joint
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7002—Longitudinal elements, e.g. rods
- A61B17/7004—Longitudinal elements, e.g. rods with a cross-section which varies along its length
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7032—Screws or hooks with U-shaped head or back through which longitudinal rods pass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7001—Screws or hooks combined with longitudinal elements which do not contact vertebrae
- A61B17/7041—Screws or hooks combined with longitudinal elements which do not contact vertebrae with single longitudinal rod offset laterally from single row of screws or hooks
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/70—Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
- A61B17/7049—Connectors, not bearing on the vertebrae, for linking longitudinal elements together
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
- A61F2/442—Intervertebral or spinal discs, e.g. resilient
Definitions
- the present invention relates generally to spinal prostheses, and more particularly, towards a method and system for stabilization of a spinal segment.
- a spinal segment includes a lumbar disc and two facet joints. Degenerative changes in the disc can lead to changes in the facet joint, and vice versa. In order to treat a degenerative condition and to alleviate the pain involved with such a malady, surgical methods may be employed to replace the degenerative component of the spinal segment, such as the damaged disc. However, the replacement of a degenerative disc may not suffice, as the facet joint components of the spinal column may still be a source of discomfort and/or limited mobility. As such, it may desirable to replace a degenerative or problematic facet joint with a posterior stabilization device.
- the degenerative process may result in a condition called spinal stenosis, where there is a narrowing of the spinal canal. This is caused by a combination of reduced disc height, ligamnetum hypertrophy, a forward slip of the vertebra and disc bulging.
- Surgery is sometime needed to deal with this condition, where a surgical procedure may involve decompression of the spine and/or the removal of posterior portions of the spinal column. This often makes the spine unstable, requiring stabilization of the spine after the decompression.
- Such stabilization may be achieved with an instrumented postero-lateral fusion, where pedicle screws are inserted into the vertebra to be fused and connected with rods or plates, and bone is laid on the side of the spine over the transverse processes.
- Stabilization may also be accomplished by a dynamic stabilization device where there is no need to add a fusion, and the device stabilizes the spine.
- a posterior dynamic stabilization device is typically attached to pedicle screws inserted in to the vertebrae, however, conventional devices are limited in their allowable range of motion and results may vary from patient to patient. It would be desirable to allow the surgeon to select or otherwise adjust the amount of motion desired in the stabilization device based on the requirements of the individual patient.
- each motion segment of the spine moves around an instantaneous center of rotation.
- the instantaneous axis of rotation is the axis perpendicular to the plane of motion passing through a point in the body that does not move.
- this point is basically the point at which the motion segment rotates about, also termed the center of rotation.
- a stabilization device which results in a minimum reduction in the natural movement of a motion segment of the spinal column when implanted, thereby reducing any additional strain on the adjacent level of the spinal segment of the individual receiving the stabilization device.
- a stabilization device able to resist and/or dampen the flexion and extension forces experienced by the motion segment during movement, while providing limited motion in the desired directions.
- a stabilization device having an adjustable path of motion that can be selectively adjusted for a particular patient or application.
- the present invention provides a dynamic stabilization device providing a minimum reduction in the natural movement of the motion segment and reducing any additional strain on the adjacent level of the spinal column in the individual receiving the stabilization device. Moreover, the present invention provides a dynamic stabilization device able to also resist and/or dampen the flexion and extension forces experienced by the motion segment during movement.
- the dynamic stabilization device may further provide an arcuate or angular path of movement that closely approximates the arc of motion of a healthy lumbar segment, while also having a selectively adjustable path of motion for a particular application or patient.
- the present invention provides a dynamic stabilization device which can continuously adjust to a moving centre of rotation of an intervertebral disc prosthesis, or that of the lumbar disc anteriorly.
- the present invention provides a dynamic stabilization device positionable about a portion of a spinal column.
- the stabilization device generally includes a first component and a second component, where the first and second components are movably coupled to one another to define an arcuate path of motion therebetween which may be selectively adjusted for a particular application.
- the first component may include a body defining an opening providing access to a first cavity or recessed region, where the first cavity is able to receive an articulating portion of the second component.
- the first and/or second components may further define one or more openings for the insertion or placement of an adjustment element that may be used to manipulate or otherwise modify the path of motion between the first and second components.
- the stabilization device may also include one or more adjustment elements positionable within first and second adjustment openings to affect the path of motion between the first and second components and/or the behavior and characteristics of the movement.
- one or more resistive elements may be adjustably positionable within either and/or both of the first and second adjustment openings to provide resistance and/or dampening of the forces experienced as the first and second components move relative to one another.
- the stabilization device may further provide multiple degrees of freedom of movement to compensate for inaccuracies experienced during implantation and/or to allow the device to adapt to movements of a spinal segment.
- the stabilization device may also include one or more attachment elements for facilitating affixation of the device to the spinal segment.
- FIG. 1 is a perspective view of an embodiment of a spinal stabilization device in accordance with the present invention
- FIG. 2 is an assembly view of an embodiment of a spinal stabilization device in accordance with the present invention
- FIG. 3 is a cross-sectional view of an embodiment of a spinal stabilization device in accordance with the present invention.
- FIG. 4 is an additional perspective view of an embodiment of a spinal stabilization device in accordance with the present invention.
- FIG. 5 is an illustrative view of a portion of an embodiment of a spinal stabilization device in accordance with the present invention.
- FIG. 6 is a side view of an embodiment of a spinal stabilization device in accordance with the present invention.
- FIG. 7 is a perspective view of an embodiment of a connector element of a spinal stabilization device in accordance with the present invention.
- FIG. 8 is a cross-sectional view of an embodiment of a connector element of a spinal stabilization device in accordance with the present invention.
- FIG. 9 is a side view of a segment of a spinal column
- FIG. 10 is a perspective view of an embodiment of a spinal stabilization device positioned about a segment of a spinal column in accordance with the present invention.
- FIG. 11 is a side view of an embodiment of a spinal stabilization device positioned about a segment of a spinal column in accordance with the present invention.
- FIG. 12 is an additional side view of an embodiment of a spinal stabilization device positioned about a segment of a spinal column in accordance with the present invention.
- FIG. 13 is another side view of an embodiment of a spinal stabilization device positioned about a segment of a spinal column in accordance with the present invention.
- the present invention provides a dynamic stabilization device 10 positionable about a portion of a spinal column.
- the present invention provides a stabilization device 10 generally including a first component 12 and a second component 14 , where the first and second components are movably coupled to one another to define a range or path of motion therebetween.
- path of motion is intended to include a length, distance and/or shape associated with the movement of either and/or both the first and second components.
- the motion of the first and second components may include an arcuate path about which the first and second components are able to articulate, where the arcuate path may define a point of rotation about which the first and second components move.
- the first component 12 may include a body defining an opening providing access to a first cavity or recessed region 16 , where the first cavity 16 is able to receive at least a portion of the second component 14 .
- the body of the first component 12 may further include a second cavity 18 or channel adjacent to or otherwise in proximity to the first cavity 16 , where a portion of the first and second cavities may be coupled or otherwise in fluid communication with each other.
- the first and second cavities may include contoured or arcuate walls extending along at least a portion of their respective lengths.
- the first component 12 may be constructed as a unitary element, or alternatively, be composed of multiple parts that are fused, welded, or otherwise assembled together to form the desired characteristics and features of the component.
- the first component 12 may include a first housing element 12 ′ and a second housing element 12 ′′ that may be fitted or otherwise coupled together.
- the first component 12 may be constructed from a myriad of biocompatible materials, including metals, plastics, and polymers as is known in the art.
- the second component 14 may define a body having an articulating portion 20 positionable within or otherwise movable about the first component 12 , where the articulating portion 20 may define an arcuate or contoured shape.
- the articulating portion 20 of the second component 14 may be movably positionable within the first cavity 16 of the first component 12 .
- the arcuate and/or contoured shapes of both the articulating portion of the second component 14 as well as the walls of the first cavity of the first component 12 may provide an arcuate path or range of motion between the two.
- the body of the second component 14 may further include a protrusion 22 extending from the articulating portion, where the protrusion 22 is positionable within the second cavity 18 of the first component 12 .
- the body of the first and/or second components may further define one or more openings for the insertion or placement of an adjustment element that may be used to manipulate or otherwise modify the path of motion between the first and second components.
- first and second adjustment openings 24 , 24 ′ may be included on either end of the first component 12 about the first and second cavities providing access thereto.
- the stabilization device 10 may include one or more adjustment elements 26 , 26 ′ positionable within the first and second adjustment openings 24 , 24 ′ to affect the path of motion between the first and second components and/or the behavior and characteristics of the movement.
- the stabilization device 10 may include one or more set screws that can be adjustably positioned within either and/or both of the first and second adjustment openings to reduce or enlarge the path of motion between the first and second components.
- the set screws may be positioned at a desired location within the first component 12 to provide a stop against which the second component 14 comes into contact with during movement to prevent and/or restrict further movement.
- one or more resistive elements 28 , 28 ′ and/or one or more dampening elements 30 , 30 ′ may be adjustably positionable within either and/or both of the first and second adjustment openings to provide resistance and/or dampening of the forces experienced as the first and second components move relative to one another.
- the resistive or dampening elements may include springs, washers, a dashpot mechanism, or the like to provide the desired movement characteristics.
- the stabilization device 10 may further provide one or more degrees of freedom of movement to compensate for inaccuracies experienced during implantation and/or to allow the device to adapt to movements of a spinal segment, including the ability to allow flexion/extension, lateral bending, and axial rotation.
- the stabilization device 10 may include a joint element 32 movably coupled to one of the first or second components, where the joint element 32 may also include a portion extending from the first and/or second components for attachment to an affixation device or the like.
- the joint element 32 may include a rounded portion 34 that forms a ball-and-socket joint with either of the first and second components, or may alternatively include a hinge or other movable construct providing one or more degrees-of-freedom of movement.
- the stabilization device 10 may also include one or more attachment elements 36 , 36 ′ for facilitating affixation to the spinal segment.
- the attachment elements 36 , 36 ′ may include a cylindrical element or extension coupled to either and/or both of the first and second components, where the attachment elements 36 , 36 ′ may be matable with a pedicle screw or other affixation element for implantation of the stabilization device 10 on a spinal segment.
- a stabilization device 50 including a first component 52 and a second component 54 movably coupled to one another to define a path of motion therebetween, where the path of motion may provide an arcuate path about which the first and second components are able to articulate.
- the first component 52 may include a body defining an opening providing access to a first cavity or recessed region for receiving at least a portion of the second component 54 .
- the second component 54 may define a body having an articulating portion positionable within or otherwise movable about the first component, where the articulating portion may define an arcuate or contoured shape.
- the articulating portion of the second component 54 may be movably positionable within the first cavity of the first component 52 .
- the arcuate and/or contoured shapes of both the articulating portion of the second component as well as the walls of the first cavity of the first component may provide an arcuate path or range of motion between the two.
- the body of the second component may further include a first protrusion 56 extending from the articulating portion, as well as a second protrusion 58 extending from the articulating portion, where both protrusions are positionable within a portion of the first component 52 .
- the body of the first and/or second components may further define one or more openings for the insertion or placement of an adjustment element that may be used to manipulate or otherwise modify the path of motion between the first and second components.
- first and second adjustment openings 60 , 60 ′ may be included on either end of the first component providing access to an interior thereof.
- the stabilization device may include one or more adjustment elements 62 , 62 ′ positionable within the first and second adjustment openings to affect the path of motion between the first and second components and/or the behavior and characteristics of the movement.
- the stabilization device may include one or more set screws that can be adjustably positioned within either and/or both of the first and second adjustment openings to reduce or enlarge the path of motion between the first and second components.
- the set screws may be positioned at a desired location within the first component to provide a stop against which the first and second protrusions of the second component 54 come into contact with during movement to prevent and/or restrict further movement.
- the path of motion may be adjustable from a length of Omm, where motion is restricted, to approximately 8 mm in a particular direction.
- the stabilization device 50 may also include one or more attachment elements for facilitating affixation to the spinal segment.
- first and second attachment elements 64 , 64 ′ may include cylindrical bodies or extensions coupled to either and/or both of the first and second components, where the attachment elements 64 , 64 ′ may be matable with a pedicle screw or other intermediate elements for implantation of the stabilization device on a spinal segment.
- the stabilization device 50 may include one or more connector elements movably positionable about the one or more attachment elements 64 , 64 ′ for affixation to a spinal segment.
- First and second connector elements 66 , 66 ′ may be included, where the connector elements define collar portions 68 , 68 ′ having an opening therethrough for movably coupling the connector elements to the first and second attachment elements, respectively.
- the collar portions 68 , 68 ′ may include an opening for the insertion of a set screw, which may be adjusted to tighten the collar about the attachment element once the desired positioning has been achieved.
- the stabilization device 50 may further include a bearing connector 70 engageable with either and/or both of the connector elements to provide for additional movement capabilities between the stabilization device and a spinal segment.
- the bearing connector 70 may define an opening 72 therethrough for the passage of either the first or second attachment elements.
- the bearing connector 70 may further movably couple to the connector element 66 as to form a ball-and-socket joint, thereby allowing the attachment element, and thus the first and second components of the stabilization device, to move and adjust to the forces and motion of a spinal segment, including flexion/extension, lateral bending, and axial rotation.
- the stabilization device may be positioned about a portion of a spinal segment.
- the human spine consists of multiple spinal segments, with a spinal segment having first and second vertebral bodies 80 , 82 , respectively, with an intervertebral disc 84 located therebetween, as shown in FIG. 9 .
- the spinal segment typically includes a vertebral endplate 86 , which is a thin layer of cartilage located between the vertebral body and the intervertebral disc.
- the vertebral bodies include both an anterior portion 88 and a posterior portion 90 corresponding to the “front” end and “back” end, respectively, of the spinal column as is known in the art.
- Each of the first and second vertebral bodies further define a midline 92 , 92 ′ equidistant from their respective anterior and posterior faces.
- Each segment of the spine moves around an instantaneous point of rotation 94 , where the point of rotation 94 is typically located next to the upper endplate 86 of the second vertebral body 82 towards substantially the posterior third of the second vertebral body.
- the exact position of a point of rotation for a particular natural and healthy spinal segment of an individual may vary to some degree, and as such, variations may be identified through medical imaging techniques providing an illustration of the path of motion for a spinal segment of interest.
- a spinal motion segment including the first and second vertebral bodies 80 , 82 with one or more stabilization elements 10 , 50 shown affixed to the posterior side of the first and second vertebral bodies.
- the first component of the stabilization device may be coupled to the first vertebral body, while the second component may be coupled to the second vertebral body.
- the stabilization element 10 may provide an arcuate path of motion between the first and second components, as discussed above. Accordingly, the path of motion of the stabilization device defines a point of rotation 96 about a portion of a reference arc 98 .
- the point of rotation 96 of the stabilization element 10 may be positioned to closely approximate that of the normal motion of the spinal segment prior to implantation.
- the point of rotation 96 may be located near the upper endplate of the second vertebral body 82 and offset from the midline of the second vertebral body 82 towards the posterior face. Further, the point of rotation 96 may be located from the posterior face a distance approximately equal to one-third of the total distance between the anterior and posterior faces. Further, although the typical point of rotation has been suggested, there may be variations in the desired positioning of the point of rotation of an implanted device due the physiology or anatomical condition of the motion segment, which may be impacted by any degradation in the vertebral bodies. The particular dimensions and/or characteristics of the stabilization element 10 may be modified and/or selected to provide a point of rotation at a desired location or distance from a reference point on the stabilization element or the spinal segment.
- the distance that the stabilization element 10 may be offset from either of the first and second vertebral bodies due to the use of affixation or connector elements may be taken into account when selecting the appropriate dimensions of the stabilization element and/or upon positioning the stabilization element 10 to ensure the point of rotation is at the desired location.
- the range of motion between the first and second components may be adjusted.
- the first and/or second adjustment elements may be movably positioned within the first component to limit the amount of movement the first and second components experience during a particular movement of the spinal segment, such as flexion and/or extension.
- resistive and/or dampening elements may be selected and positioned within a portion of the first component to further manipulate the motion characteristics for a given application. For example, in certain circumstance, it may be desirable to provide an increased resistance amount across a particular span of motion experienced by the stabilization device, while at other times it may be desirable to have less resistance. Varying levels of resistance and/or dampening may be achieved by selecting a particular element having the mechanical and/or material characteristics that would produce the preferred result.
- the stabilization element Once the stabilization element is implanted, subsequent forces and movement experienced by the vertebral bodies will translate to the stabilization element 10 , thus causing movement of the relative portions of the device within the desired adjusted path. For example, should the motion segment experience flexion, the first and second portions of the stabilization element will also move about its point of rotation. In addition, should the two vertebral bodies experience an extension, the portions of the stabilization element will adjust accordingly. As the centers of rotation of the two components are aligned and/or matched to that of the natural motion of the spinal segment, resulting movement of the spinal segment upon implantation of the prostheses will approximate the natural physiological movement of the spinal segment prior to implantation of the devices.
- the stabilization element may further provide the ability to continuously adjust to a moving centre of rotation of the vertebral disc prosthesis, or that of a normal motion segment in the event a disc prosthesis is not implanted.
- the relative movement of the first and second portions of the stabilization element may include several degrees of freedom by incorporating one or more joint elements and/or ball-and-socket joints between a connector element and a bearing connector in order to readily accommodate the motion experienced by the spinal segment during the period of use of the stabilization element.
- This self-regulating, adaptive feature may provide a safeguard against initial center-or-rotation mismatches introduced at the time of implantation, and may further regulate center-of-rotation deficits experienced during the course of use of the prostheses.
Abstract
The present invention provides a dynamic stabilization device positionable about a portion of a spinal column. The stabilization device may generally include a first component and a second component, where the first and second components are movably coupled to one another to define an arcuate path of motion. The stabilization device may also include one or more adjustment elements positionable within first and second adjustment openings to affect the path of motion between the first and second components and/or the behavior and characteristics of the movement. In addition, one or more resistive elements may be adjustably positionable within either and/or both of the first and second adjustment openings to provide resistance and/or dampening of the forces experienced as the first and second components move relative to one another. The stabilization device may further define a joint having three degrees of freedom to adapt to movement of a spinal column.
Description
- This application is related to and claims priority to U.S. Provisional Patent Application Ser. No. 60/847,069, filed Sep. 25, 2006, entitled PROSTHETIC FACET JOINT COMPONENT, and U.S. Provisional Patent Application Ser. No. 60/811,843, filed Jun. 8, 2006, entitled PROSTHETIC FACET JOINT, the entirety of each of which is incorporated herein by reference.
- n/a
- The present invention relates generally to spinal prostheses, and more particularly, towards a method and system for stabilization of a spinal segment.
- A significant portion of the population has experiences pain or discomfort resulting from spinal injuries or degenerative conditions in and around the vertebral discs. While many individuals may simply experience minor sprains or strains that may be somewhat limiting, numerous individuals may develop severe lower back pain caused by inflammatory changes in the lumbar disc associated with such changes.
- A spinal segment includes a lumbar disc and two facet joints. Degenerative changes in the disc can lead to changes in the facet joint, and vice versa. In order to treat a degenerative condition and to alleviate the pain involved with such a malady, surgical methods may be employed to replace the degenerative component of the spinal segment, such as the damaged disc. However, the replacement of a degenerative disc may not suffice, as the facet joint components of the spinal column may still be a source of discomfort and/or limited mobility. As such, it may desirable to replace a degenerative or problematic facet joint with a posterior stabilization device.
- In addition, the degenerative process may result in a condition called spinal stenosis, where there is a narrowing of the spinal canal. This is caused by a combination of reduced disc height, ligamnetum hypertrophy, a forward slip of the vertebra and disc bulging. Surgery is sometime needed to deal with this condition, where a surgical procedure may involve decompression of the spine and/or the removal of posterior portions of the spinal column. This often makes the spine unstable, requiring stabilization of the spine after the decompression. Such stabilization may be achieved with an instrumented postero-lateral fusion, where pedicle screws are inserted into the vertebra to be fused and connected with rods or plates, and bone is laid on the side of the spine over the transverse processes. Stabilization may also be accomplished by a dynamic stabilization device where there is no need to add a fusion, and the device stabilizes the spine. A posterior dynamic stabilization device is typically attached to pedicle screws inserted in to the vertebrae, however, conventional devices are limited in their allowable range of motion and results may vary from patient to patient. It would be desirable to allow the surgeon to select or otherwise adjust the amount of motion desired in the stabilization device based on the requirements of the individual patient.
- However, each motion segment of the spine moves around an instantaneous center of rotation. The instantaneous axis of rotation is the axis perpendicular to the plane of motion passing through a point in the body that does not move. For each spinal motion segment this point is basically the point at which the motion segment rotates about, also termed the center of rotation. If the spine is altered in any way, such as with disc and facet degeneration or spinal implantation, this center of rotation shifts, leading to undesirable consequences, such as further degradation, limited movement ability, etc.
- Accordingly, it would be desirable to provide a stabilization device which results in a minimum reduction in the natural movement of a motion segment of the spinal column when implanted, thereby reducing any additional strain on the adjacent level of the spinal segment of the individual receiving the stabilization device. Moreover, it would be desirable to provide a stabilization device able to resist and/or dampen the flexion and extension forces experienced by the motion segment during movement, while providing limited motion in the desired directions. It would also be desirable to provide a stabilization device having an adjustable path of motion that can be selectively adjusted for a particular patient or application. In addition, it would further be desirable to provide a stabilization device which can continuously adjust to a moving centre of rotation of a disc prosthesis, or, if used on its own, with that of the lumbar disc anteriorly.
- The present invention provides a dynamic stabilization device providing a minimum reduction in the natural movement of the motion segment and reducing any additional strain on the adjacent level of the spinal column in the individual receiving the stabilization device. Moreover, the present invention provides a dynamic stabilization device able to also resist and/or dampen the flexion and extension forces experienced by the motion segment during movement. The dynamic stabilization device may further provide an arcuate or angular path of movement that closely approximates the arc of motion of a healthy lumbar segment, while also having a selectively adjustable path of motion for a particular application or patient. Furthermore, the present invention provides a dynamic stabilization device which can continuously adjust to a moving centre of rotation of an intervertebral disc prosthesis, or that of the lumbar disc anteriorly.
- In particular, the present invention provides a dynamic stabilization device positionable about a portion of a spinal column. The stabilization device generally includes a first component and a second component, where the first and second components are movably coupled to one another to define an arcuate path of motion therebetween which may be selectively adjusted for a particular application. The first component may include a body defining an opening providing access to a first cavity or recessed region, where the first cavity is able to receive an articulating portion of the second component.
- The first and/or second components may further define one or more openings for the insertion or placement of an adjustment element that may be used to manipulate or otherwise modify the path of motion between the first and second components. The stabilization device may also include one or more adjustment elements positionable within first and second adjustment openings to affect the path of motion between the first and second components and/or the behavior and characteristics of the movement. In addition to the adjustment elements, one or more resistive elements may be adjustably positionable within either and/or both of the first and second adjustment openings to provide resistance and/or dampening of the forces experienced as the first and second components move relative to one another.
- The stabilization device may further provide multiple degrees of freedom of movement to compensate for inaccuracies experienced during implantation and/or to allow the device to adapt to movements of a spinal segment. In addition, the stabilization device may also include one or more attachment elements for facilitating affixation of the device to the spinal segment.
- A more complete understanding of the present invention, and the attendant advantages and features thereof, will be more readily understood by reference to the following detailed description when considered in conjunction with the accompanying drawings wherein:
-
FIG. 1 is a perspective view of an embodiment of a spinal stabilization device in accordance with the present invention; -
FIG. 2 is an assembly view of an embodiment of a spinal stabilization device in accordance with the present invention; -
FIG. 3 is a cross-sectional view of an embodiment of a spinal stabilization device in accordance with the present invention; -
FIG. 4 is an additional perspective view of an embodiment of a spinal stabilization device in accordance with the present invention; -
FIG. 5 is an illustrative view of a portion of an embodiment of a spinal stabilization device in accordance with the present invention; -
FIG. 6 is a side view of an embodiment of a spinal stabilization device in accordance with the present invention; -
FIG. 7 is a perspective view of an embodiment of a connector element of a spinal stabilization device in accordance with the present invention; -
FIG. 8 is a cross-sectional view of an embodiment of a connector element of a spinal stabilization device in accordance with the present invention; -
FIG. 9 is a side view of a segment of a spinal column; -
FIG. 10 is a perspective view of an embodiment of a spinal stabilization device positioned about a segment of a spinal column in accordance with the present invention; -
FIG. 11 is a side view of an embodiment of a spinal stabilization device positioned about a segment of a spinal column in accordance with the present invention; -
FIG. 12 is an additional side view of an embodiment of a spinal stabilization device positioned about a segment of a spinal column in accordance with the present invention; and -
FIG. 13 is another side view of an embodiment of a spinal stabilization device positioned about a segment of a spinal column in accordance with the present invention. - The present invention provides a
dynamic stabilization device 10 positionable about a portion of a spinal column. Now referring toFIGS. 1-3 , the present invention provides astabilization device 10 generally including afirst component 12 and asecond component 14, where the first and second components are movably coupled to one another to define a range or path of motion therebetween. As used herein, the term “path of motion” is intended to include a length, distance and/or shape associated with the movement of either and/or both the first and second components. The motion of the first and second components may include an arcuate path about which the first and second components are able to articulate, where the arcuate path may define a point of rotation about which the first and second components move. - In particular, the
first component 12 may include a body defining an opening providing access to a first cavity or recessedregion 16, where thefirst cavity 16 is able to receive at least a portion of thesecond component 14. The body of thefirst component 12 may further include asecond cavity 18 or channel adjacent to or otherwise in proximity to thefirst cavity 16, where a portion of the first and second cavities may be coupled or otherwise in fluid communication with each other. Further, the first and second cavities may include contoured or arcuate walls extending along at least a portion of their respective lengths. Of note, thefirst component 12 may be constructed as a unitary element, or alternatively, be composed of multiple parts that are fused, welded, or otherwise assembled together to form the desired characteristics and features of the component. For example, thefirst component 12 may include afirst housing element 12′ and asecond housing element 12″ that may be fitted or otherwise coupled together. Moreover, thefirst component 12 may be constructed from a myriad of biocompatible materials, including metals, plastics, and polymers as is known in the art. - The
second component 14 may define a body having an articulatingportion 20 positionable within or otherwise movable about thefirst component 12, where the articulatingportion 20 may define an arcuate or contoured shape. For example, the articulatingportion 20 of thesecond component 14 may be movably positionable within thefirst cavity 16 of thefirst component 12. The arcuate and/or contoured shapes of both the articulating portion of thesecond component 14 as well as the walls of the first cavity of thefirst component 12 may provide an arcuate path or range of motion between the two. In addition, the body of thesecond component 14 may further include aprotrusion 22 extending from the articulating portion, where theprotrusion 22 is positionable within thesecond cavity 18 of thefirst component 12. - The body of the first and/or second components may further define one or more openings for the insertion or placement of an adjustment element that may be used to manipulate or otherwise modify the path of motion between the first and second components. For example, first and
second adjustment openings first component 12 about the first and second cavities providing access thereto. In addition, thestabilization device 10 may include one ormore adjustment elements second adjustment openings stabilization device 10 may include one or more set screws that can be adjustably positioned within either and/or both of the first and second adjustment openings to reduce or enlarge the path of motion between the first and second components. The set screws may be positioned at a desired location within thefirst component 12 to provide a stop against which thesecond component 14 comes into contact with during movement to prevent and/or restrict further movement. In addition to theadjustment elements resistive elements elements - The
stabilization device 10 may further provide one or more degrees of freedom of movement to compensate for inaccuracies experienced during implantation and/or to allow the device to adapt to movements of a spinal segment, including the ability to allow flexion/extension, lateral bending, and axial rotation. For example, thestabilization device 10 may include ajoint element 32 movably coupled to one of the first or second components, where thejoint element 32 may also include a portion extending from the first and/or second components for attachment to an affixation device or the like. Thejoint element 32 may include arounded portion 34 that forms a ball-and-socket joint with either of the first and second components, or may alternatively include a hinge or other movable construct providing one or more degrees-of-freedom of movement. - The
stabilization device 10 may also include one ormore attachment elements attachment elements attachment elements stabilization device 10 on a spinal segment. - Now referring to
FIGS. 4-6 , astabilization device 50 is shown including afirst component 52 and asecond component 54 movably coupled to one another to define a path of motion therebetween, where the path of motion may provide an arcuate path about which the first and second components are able to articulate. - In particular, the
first component 52 may include a body defining an opening providing access to a first cavity or recessed region for receiving at least a portion of thesecond component 54. Thesecond component 54 may define a body having an articulating portion positionable within or otherwise movable about the first component, where the articulating portion may define an arcuate or contoured shape. For example, the articulating portion of thesecond component 54 may be movably positionable within the first cavity of thefirst component 52. The arcuate and/or contoured shapes of both the articulating portion of the second component as well as the walls of the first cavity of the first component may provide an arcuate path or range of motion between the two. In addition, the body of the second component may further include afirst protrusion 56 extending from the articulating portion, as well as asecond protrusion 58 extending from the articulating portion, where both protrusions are positionable within a portion of thefirst component 52. - The body of the first and/or second components may further define one or more openings for the insertion or placement of an adjustment element that may be used to manipulate or otherwise modify the path of motion between the first and second components. For example, first and
second adjustment openings more adjustment elements second component 54 come into contact with during movement to prevent and/or restrict further movement. In an exemplary embodiment, the path of motion may be adjustable from a length of Omm, where motion is restricted, to approximately 8 mm in a particular direction. - The
stabilization device 50 may also include one or more attachment elements for facilitating affixation to the spinal segment. For example, first andsecond attachment elements attachment elements - In addition, the
stabilization device 50 may include one or more connector elements movably positionable about the one ormore attachment elements second connector elements collar portions collar portions - The
stabilization device 50 may further include a bearingconnector 70 engageable with either and/or both of the connector elements to provide for additional movement capabilities between the stabilization device and a spinal segment. Now referring toFIGS. 7 and 8 , the bearingconnector 70 may define anopening 72 therethrough for the passage of either the first or second attachment elements. The bearingconnector 70 may further movably couple to theconnector element 66 as to form a ball-and-socket joint, thereby allowing the attachment element, and thus the first and second components of the stabilization device, to move and adjust to the forces and motion of a spinal segment, including flexion/extension, lateral bending, and axial rotation. - In an exemplary use of the present invention, the stabilization device may be positioned about a portion of a spinal segment. Primarily, the human spine consists of multiple spinal segments, with a spinal segment having first and second
vertebral bodies intervertebral disc 84 located therebetween, as shown inFIG. 9 . Moreover, the spinal segment typically includes avertebral endplate 86, which is a thin layer of cartilage located between the vertebral body and the intervertebral disc. The vertebral bodies include both ananterior portion 88 and aposterior portion 90 corresponding to the “front” end and “back” end, respectively, of the spinal column as is known in the art. Each of the first and second vertebral bodies further define amidline rotation 94, where the point ofrotation 94 is typically located next to theupper endplate 86 of the secondvertebral body 82 towards substantially the posterior third of the second vertebral body. The exact position of a point of rotation for a particular natural and healthy spinal segment of an individual may vary to some degree, and as such, variations may be identified through medical imaging techniques providing an illustration of the path of motion for a spinal segment of interest. - Now referring to
FIGS. 10-13 , a spinal motion segment is shown including the first and secondvertebral bodies more stabilization elements stabilization element 10 may provide an arcuate path of motion between the first and second components, as discussed above. Accordingly, the path of motion of the stabilization device defines a point of rotation 96 about a portion of areference arc 98. The point of rotation 96 of thestabilization element 10 may be positioned to closely approximate that of the normal motion of the spinal segment prior to implantation. The point of rotation 96 may be located near the upper endplate of the secondvertebral body 82 and offset from the midline of the secondvertebral body 82 towards the posterior face. Further, the point of rotation 96 may be located from the posterior face a distance approximately equal to one-third of the total distance between the anterior and posterior faces. Further, although the typical point of rotation has been suggested, there may be variations in the desired positioning of the point of rotation of an implanted device due the physiology or anatomical condition of the motion segment, which may be impacted by any degradation in the vertebral bodies. The particular dimensions and/or characteristics of thestabilization element 10 may be modified and/or selected to provide a point of rotation at a desired location or distance from a reference point on the stabilization element or the spinal segment. The distance that thestabilization element 10 may be offset from either of the first and second vertebral bodies due to the use of affixation or connector elements may be taken into account when selecting the appropriate dimensions of the stabilization element and/or upon positioning thestabilization element 10 to ensure the point of rotation is at the desired location. - Upon achieving the desired positioning of the stabilization device to the spinal segment, the range of motion between the first and second components may be adjusted. For example, the first and/or second adjustment elements may be movably positioned within the first component to limit the amount of movement the first and second components experience during a particular movement of the spinal segment, such as flexion and/or extension. Moreover, resistive and/or dampening elements may be selected and positioned within a portion of the first component to further manipulate the motion characteristics for a given application. For example, in certain circumstance, it may be desirable to provide an increased resistance amount across a particular span of motion experienced by the stabilization device, while at other times it may be desirable to have less resistance. Varying levels of resistance and/or dampening may be achieved by selecting a particular element having the mechanical and/or material characteristics that would produce the preferred result.
- Once the stabilization element is implanted, subsequent forces and movement experienced by the vertebral bodies will translate to the
stabilization element 10, thus causing movement of the relative portions of the device within the desired adjusted path. For example, should the motion segment experience flexion, the first and second portions of the stabilization element will also move about its point of rotation. In addition, should the two vertebral bodies experience an extension, the portions of the stabilization element will adjust accordingly. As the centers of rotation of the two components are aligned and/or matched to that of the natural motion of the spinal segment, resulting movement of the spinal segment upon implantation of the prostheses will approximate the natural physiological movement of the spinal segment prior to implantation of the devices. - In addition to providing an aligned and/or matched point of rotation between the intervertebral disc prosthesis and the stabilization element to provide proper physiological movement upon implantation, the stabilization element may further provide the ability to continuously adjust to a moving centre of rotation of the vertebral disc prosthesis, or that of a normal motion segment in the event a disc prosthesis is not implanted. As discussed above, the relative movement of the first and second portions of the stabilization element may include several degrees of freedom by incorporating one or more joint elements and/or ball-and-socket joints between a connector element and a bearing connector in order to readily accommodate the motion experienced by the spinal segment during the period of use of the stabilization element. This self-regulating, adaptive feature may provide a safeguard against initial center-or-rotation mismatches introduced at the time of implantation, and may further regulate center-of-rotation deficits experienced during the course of use of the prostheses.
- It will be appreciated by persons skilled in the art that the present invention is not limited to what has been particularly shown and described herein above. In addition, unless mention was made above to the contrary, it should be noted that all of the accompanying drawings are not to scale. A variety of modifications and variations are possible in light of the above teachings without departing from the scope and spirit of the invention, which is limited only by the following claims.
Claims (31)
1. A spinal stabilization device, comprising:
a first component adapted to be coupled to a posterior side of a spinal segment, and
a second component adapted to be coupled to a posterior side of a spinal segment, wherein the second component is movably coupled to the first component to define an arcuate path of motion.
2. The spinal stabilization device according to claim 1 , wherein the path of motion between first and second components is selectively adjustable.
3. The spinal stabilization device according to claim 2 , further including a first adjustment element coupled to at least one of the first and second components to affect the path of motion between the first and second components.
4. The spinal stabilization device according to claim 3 , wherein the first component defines a first adjustment opening, and wherein the adjustment element is movably positionable within the first adjustment opening.
5. The spinal stabilization device according to claim 4 , wherein the first component defines a second adjustment opening, the spinal stabilization device further comprising a second adjustment element movably positionable within the second adjustment opening.
6. The spinal stabilization device according to claim 4 , further comprising at least one of a resistive element and a dampening element positionable within the first adjustment opening.
7. The spinal stabilization device according to claim 5 , further comprising at least one of a resistive element and a dampening element positionable within the second adjustment opening.
8. The spinal stabilization device according to claim 1 , further comprising a joint element movably coupled to at least one of the first and second components, wherein the joint element provides at least two degrees-of-freedom of movement.
9. The spinal stabilization device according to claim 8 , wherein the joint element provides at least three degrees-of-freedom of movement.
10. The spinal stabilization device according to claim 1 , further comprising a first attachment element coupled to the first component, and a second attachment element coupled to the second component to facilitate attachment of the spinal stabilization device to a spinal segment.
11. The spinal stabilization device according to claim 10 , further comprising a first connector element coupled to the first attachment element, wherein the first connector element defines a collar portion and an opening therein, and wherein at least a portion of the first attachment element is positionable within the opening in the collar portion.
12. The spinal stabilization device according to claim 11 , further comprising a second connector element coupled to the second attachment element, wherein the second connector element defines a collar portion and an opening therein, and wherein at least a portion of the second attachment element is positionable within the opening in the collar portion.
13. The spinal stabilization device according to claim 11 , further comprising a bearing connector coupled to the first connector element, wherein the bearing connector and the first connector element are coupled to form a joint having at least two degrees-of-freedom.
14. The spinal stabilization device according to claim 13 , wherein the bearing connector and the first connector element are coupled to form a joint having at least three degrees-of-freedom.
15. A spinal stabilization device, comprising:
a first component adapted to be coupled to a posterior side of a spinal segment, and
a second component adapted to be coupled to a posterior side of a spinal segment, wherein the second component is movably coupled to the first component to define a path of motion that is selectively adjustable.
16. The spinal stabilization device according to claim 15 , further comprising a first adjustment element movably positionable within the first component to contact at least a portion of the second component.
17. The spinal stabilization device according to claim 16 , further comprising a second adjustment element movably positionable within the first component to contact at least a portion of the second component.
18. A spinal stabilization device, comprising:
a first component defining a first adjustment opening and a second adjustment opening;
a first adjustment element movably positionable within the first adjustment opening,
a second adjustment element movably positionable within the second adjustment opening;
at least one of a resistive element and a dampening element positionable within at least one of the first adjustment opening and second adjustment opening; and
a second component movably coupled to the first component, wherein the first and second components define an arcuate path of motion, and wherein the spinal stabilization device defines a joint having at least two degrees of freedom.
19. The spinal stabilization device according to claim 18 , wherein the spinal stabilization device defines a joint having at least three degrees of freedom.
20. A method of performing spinal arthroplasty, comprising the steps of:
providing a first spinal stabilization device having a first component and a second component movably coupled to the first component, wherein the first and second components define a first arcuate path of motion;
coupling the first component of the first spinal stabilization device to a portion of a first vertebral body; and
coupling the second component of the first spinal stabilization device to a portion of a second vertebral body.
21. The method according to claim 20 , wherein the first component is coupled to a posterior side of the first vertebral body.
22. The method according to claim 21 , wherein the second component is coupled to a posterior side of the second vertebral body
23. The method according to claim 20 , further comprising the step of adjusting the first path of motion.
24. The method according to claim 23 , wherein the step of adjusting the first path of motion includes positioning a first adjustment element to contact a portion of the second component.
25. The method according to claim 24 , wherein the first adjustment element is coupled to the first component.
26. The method according to claim 20 , further comprising the step of adjusting a resistance to the motion between the first and second components of the first stabilization device.
27. The method according to claim 20 , further comprising the steps of:
providing a second spinal stabilization device having a first component and a second component movably coupled to the first component, wherein the first and second components define a second arcuate path of motion;
coupling the first component of the second spinal stabilization device to a posterior portion of the first vertebral body; and
coupling the second component of the second spinal stabilization device to a posterior portion of the second vertebral body.
28. The method according to claim 27 , further comprising the step of adjusting the second path of motion.
29. The method according to claim 28 , wherein the step of adjusting the second path of motion includes positioning a second adjustment element to contact a portion of the second component of the second stabilization element.
30. The method according to claim 29 , wherein the second adjustment element is coupled to the first component of the second stabilization element.
31. The method according to claim 27 , further comprising the step of adjusting a resistance to the motion between the first and second components of the second stabilization device.
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EP07755691A EP2034915A2 (en) | 2006-06-08 | 2007-04-19 | Dynamic spinal stabilization device |
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US12/124,374 US8147518B2 (en) | 2006-06-08 | 2008-05-21 | Dynamic connector for spinal device |
US29/326,534 USD618348S1 (en) | 2007-03-23 | 2008-10-20 | Spinal stabilization device |
US29/326,552 USD618349S1 (en) | 2007-03-23 | 2008-10-20 | Spinal stabilization device |
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US20210038263A1 (en) * | 2017-10-18 | 2021-02-11 | Texas Scottish Rite Hospital For Children | Deformable Dynamization Device |
US20190110816A1 (en) * | 2017-10-18 | 2019-04-18 | Texas Scottish Rite Hospital For Children | Deformable dynamization device |
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Also Published As
Publication number | Publication date |
---|---|
US20080228227A1 (en) | 2008-09-18 |
WO2007145706A2 (en) | 2007-12-21 |
EP2034915A2 (en) | 2009-03-18 |
WO2007145706A3 (en) | 2008-03-06 |
US8147518B2 (en) | 2012-04-03 |
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